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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA2 Gene

protein-coding   GIFtS: 67
GCID: GC14P065002

Heat Shock 70kDa Protein 2

(Previous name: heat shock 70kD protein 2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 21 2
Heat Shock 70kD Protein 21 2
HSP70-22
HSP70-32
Heat Shock-Related 70 KDa Protein 22
Heat Shock 70 KDa Protein 23

External Ids:    HGNC: 52351   Entrez Gene: 33062   Ensembl: ENSG000001268037   OMIM: 1405605   UniProtKB: P546523   

Export aliases for HSPA2 gene to outside databases

Previous GC identifers: GC14P062330 GC14P058796 GC14P062992 GC14P064072 GC14P045179


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPA2 Gene: 
HSPA2 (heat shock 70kDa protein 2) is a protein-coding gene. Diseases associated with HSPA2 include visceral leishmaniasis, and varicocele, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Meiotic Synapsis. GO annotations related to this gene include unfolded protein binding and glycolipid binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage

Gene Wiki entry for HSPA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA2 gene promoter:
         p53   HTF   Pax-2   Pax-2a   Tal-1beta   CP2   Ik-2   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23

HSPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065002:  view genomic region     (about GC identifiers)

Start:
65,002,623 bp from pter      End:
65,009,955 bp from pter
Size:
7,333 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652 (See protein sequence)
Recommended Name: Heat shock-related 70 kDa protein 2  
Size: 639 amino acids; 70021 Da
Subunit: Interacts with ZNF541. Component of the CatSper complex (By similarity)
2 PDB 3D structures from and Proteopedia for HSPA2:
3I33 (3D)        4FSV (3D)    
Secondary accessions: Q15508 Q53XM3 Q9UE78

Explore the universe of human proteins at neXtProt for HSPA2: NX_P54652

Explore proteomics data for HSPA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54652

  • HSPA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA2 Protein Expression
    REFSEQ proteins: NP_068814.2  
    ENSEMBL proteins: 
     ENSP00000378199   ENSP00000247207  
    Reactome Protein details: P54652
    Human Recombinant Protein Products for HSPA2: 
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    Novus Biologicals HSPA2 Protein
    Novus Biologicals HSPA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex IEA--
    GO:0001673male germ cell nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0009986cell surface IDA12493773
    GO:0036128CatSper complex ISS--

    HSPA2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P54652

    ProtoNet protein and cluster: P54652

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652
    Similarity: Belongs to the heat shock protein 70 family


    HSPA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP72_HUMAN, P54652
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage

         Genatlas biochemistry entry for HSPA2:
    heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohn's disease

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding TAS3037489
    GO:0051861glycolipid binding IEA--
         
    HSPA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hspa2):
     endocrine/exocrine gland  reproductive system 

    HSPA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hspa2tm1Dix for HSPA2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA2 
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    SwitchGear 3'UTR luciferase reporter plasmidHSPA2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA2 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Meiotic Synapsis
    Meiotic Synapsis0.70
    Chromosome Maintenance0.56
    Meiosis0.70
    3CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    CFTR folding and maturation (norm and CF)0.37
    4Influenza A
    Influenza A0.34
    Measles0.34
    5Proteolysis Putative ubiquitin pathway
    Proteolysis Putative ubiquitin pathway0.97

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA2
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway


    5/6 GeneGo (Thomson Reuters) Pathways for HSPA2 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA2
        Parkin-Ubiquitin Proteasomal System pathway


    4        Reactome Pathways for HSPA2
        Meiotic Synapsis
    Cell Cycle
    Meiosis
    Chromosome Maintenance


    5/11         Kegg Pathways  (Kegg details for HSPA2) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/171 Interacting proteins for HSPA2 (P546521, 2, 3 ENSP000002472074) via UniProtKB, MINT, STRING, and/or I2D (see all 171)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPBP1Q9NZL41, 2, 3, ENSP000002556314EBI-356991,EBI-356763 MINT-2871513 MINT-66487 I2D: score=5 STRING: ENSP00000255631
    MAP3K3Q997592, 3, ENSP000003549274MINT-48390 I2D: score=3 STRING: ENSP00000354927
    MEOX2P502222, 3, ENSP000002620414MINT-2860884 I2D: score=3 STRING: ENSP00000262041
    RIPK2O433532, 3MINT-49058 I2D: score=2 
    TAB2Q9NYJ82, 3MINT-49186 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0006986response to unfolded protein TAS7829106
    GO:0007140male meiosis TAS8622925
    GO:0007141male meiosis I IEA--

    HSPA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA2 (HSP72)

    Search CenterWatch for drugs/clinical trials and news about HSPA2 / HSP72

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA2 gene: 
    NM_021979.3  

    Unigene Cluster for HSPA2:

    Heat shock 70kDa protein 2
    Hs.432648  [show with all ESTs]
    Unigene Representative Sequence: NM_021979
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394709(uc001xhj.3) ENST00000554883 ENST00000247207(uc001xhk.4)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA2:
    hsa-miR-4311 hsa-miR-1271 hsa-miR-371-5p hsa-miR-382 hsa-miR-19b hsa-miR-3143 hsa-miR-96 hsa-miR-19a
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    Additional mRNA sequence: 

    AK097824.1 BC001752.1 BC034365.1 BC036107.1 BT009815.1 

    12 DOTS entries:

    DT.100026736  DT.91785830  DT.101983142  DT.120759401  DT.100689865  DT.100878670  DT.95365758  DT.100675724 
    DT.100878669  DT.120759371  DT.120759393  DT.92334502 

    24/243 AceView cDNA sequences (see all 243):

    BT009815 CR601466 BU188162 BP373997 BX381080 BM453285 CR596961 AI580818 
    BQ422962 BM672824 AL040891 CB152018 CA389240 AL040890 CD299958 AA425007 
    CN482552 BU752272 T28755 BC001752 BP341969 CB155424 BP375233 BX360652 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
    SP1:        -     -                                                               
    SP2:              -                                                               
    SP3:                          -     -     -                                       
    SP4:                                -     -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for HSPA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA2 expression in normal human tissues (normalized intensities)      HSPA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATTTGTT
    HSPA2 Expression
    About this image


    HSPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/19 selected tissues (see all 19) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor E72
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Human Mesenchymal Stem Cell-hepatic (HMSC-he)   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor

    See HSPA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA2

    SOURCE GeneReport for Unigene cluster: Hs.432648
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Cardiotoxicity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA2 gene from 9/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa21 , 5 heat shock protein 21, 5 92(n)1
    99.37(a)1
      12 (33.73 cM)5
    155121  NM_001002012.11  NP_001002012.11 
     764041765 
    chicken
    (Gallus gallus)
    Aves HSPA21 heat shock 70kDa protein 2 80.7(n)
    92.11(a)
      423504  NM_001006685.1  NP_001006686.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA26
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    92(a)
    84(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    1(1380946-1382853)
    LGf(897907-924982)
    zebrafish
    (Danio rerio)
    Actinopterygii hsc706
    heat shock cognate 70
    84(a)
    possible ortholog
    15(36534327-36549380)
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43 neurotransmitter secretion chaperone 83(a)
    (best of 11)
      88E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSB2(YNL209W)4 Cytoplasmic ATPase that is a ribosome-associated molecular more   --   14(252059-253900) 855512  NP_014190.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERD21 heat shock protein-70 cognate protein 65.68(n)
    74.59(a)
      842094  NM_104519.1  NP_176036.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.245152 Triticum aestivum 70 kDa heat shock protein (TaHSP7 more 82.78(n)    AF005993.1 


    ENSEMBL Gene Tree for HSPA2 (if available)
    TreeFam Gene Tree for HSPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA2 gene
    HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA132  HSPA1A2  
    15 SIMAP similar genes for HSPA2 using alignment to 1 protein entry:     HSP72_HUMAN:
    HSPA1B    HSPA1L    HSPA1A    HSP70-1    HSPA6    HSPA8
    HSPA7    LOC401308    HSPA5    HSPA9    HSPA14    HS24/p52
    HSPA13    HSPA4L    HSPA4

    HSPA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/158 SNPs in HSPA2 are shown (see all 158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0327074
    ----see VAR_0327072 K E mis40--------
    rs43137341,2
    C,F,A,H--65005228(+) CACAAT/CCTATG 1 -- us2k125Minor allele frequency- C:0.36NS EA NA WA 2526
    rs1473989931,2
    --65005233(+) CCTATA/GTAAAG 1 -- us2k10--------
    rs1396980441,2
    --65005244(+) AATGGC/TTTTCC 1 -- us2k10--------
    rs455640311,2
    C,F--65005317(+) AGCAAC/TGCACT 1 -- us2k16Minor allele frequency- T:0.01NS NA 186
    rs455110971,2
    C,F--65005318(+) GCAACG/ACACTT 1 -- us2k17Minor allele frequency- A:0.05NS NA 306
    rs1846341221,2
    --65005466(+) TAGTAA/GGTACC 1 -- us2k10--------
    rs1471584181,2
    --65005551(+) TCCTGA/GAGACC 1 -- us2k10--------
    rs1404038011,2
    --65005558(+) GACCAC/TTTATT 1 -- us2k10--------
    rs1886718561,2
    --65005561(+) CATTTA/GTTTTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSPA2 (65002623 - 65009955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSPA2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv1308CNV Insertion18451855

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140560    OMIM disorders: --

    20 diseases for HSPA2:    About MalaCards
    visceral leishmaniasis    varicocele    h. pylori infection    toxoplasmosis
    leishmaniasis    ankylosing spondylitis    measles    spondylitis
    male infertility    crohn's disease    ulcerative colitis    infertility
    systemic lupus erythematosus    inflammatory bowel disease    pneumonia    influenza
    lupus erythematosus    alcoholism    alzheimer's disease    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for HSPA2:
    Male infertility

    HSPA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HSPA2
    Human Genome Epidemiology (HuGE) Navigator: HSPA2 (16 documents)

    Export disorders for HSPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA2 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with HSPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (PubMed id 19661373)1, 4 Tahara T....Hirata I. (2009)
    2. HLA-association of serum levels of natural antibodies. (PubMed id 19167759)1, 4 Pozsonyi E....FA1st G. (2009)
    3. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. (PubMed id 18813331)1, 4 Konings A....Van Camp G. (2008)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    5. Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis. (PubMed id 17940904)1, 4 Lee S.H....Yoon Y.B. (2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    7. Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease. (PubMed id 17532782)1, 4 Nam S.Y....Song I.S. (2007)
    8. [The heat shock protein 70-2 gene +1267(A/G) polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population] (PubMed id 17922431)1, 4 Lin J.A....Chen R.Q. (2007)
    9. [Influence of alleles and haplotypes of the main histocompatibility complex on the susceptibility to systemic lupus erythematosus in the Mexican population] (PubMed id 16875346)1, 4 Granados J....Vargas-Alarcon G. (2006)
    10. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. (PubMed id 17009596)1, 4 Yang M....Wu T. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3306 HGNC: 5235 AceView: HSPA2 Ensembl:ENSG00000126803 euGenes: HUgn3306
    ECgene: HSPA2 Kegg: 3306 H-InvDB: HSPA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA2 gene:
    Search GeneIP for patents involving HSPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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