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HSPA2 Gene

protein-coding   GIFtS: 68
GCID: GC14P065002

Heat Shock 70kDa Protein 2

(Previous name: heat shock 70kD protein 2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 21 2
Heat Shock 70kD Protein 21 2
HSP70-22
HSP70-32
Heat Shock-Related 70 KDa Protein 22
Heat Shock 70 KDa Protein 23

External Ids:    HGNC: 52351   Entrez Gene: 33062   Ensembl: ENSG000001268037   OMIM: 1405605   UniProtKB: P546523   

Export aliases for HSPA2 gene to outside databases

Previous GC identifers: GC14P062330 GC14P058796 GC14P062992 GC14P064072 GC14P045179


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSPA2 Gene:
HSPA2 (heat shock 70kDa protein 2) is a protein-coding gene. Diseases associated with HSPA2 include legionellosis, and visceral leishmaniasis. GO annotations related to this gene include unfolded protein binding and glycolipid binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage

Gene Wiki entry for HSPA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA2 gene promoter:
         p53   HTF   Pax-2   Pax-2a   Tal-1beta   CP2   Ik-2   POU2F1   POU2F1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSPA2 promoter sequence
   Search Chromatin IP Primers for HSPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q23

HSPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065002:  view genomic region     (about GC identifiers)

Start:
65,002,623 bp from pter      End:
65,009,955 bp from pter
Size:
7,333 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652 (See protein sequence)
Recommended Name: Heat shock-related 70 kDa protein 2  
Size: 639 amino acids; 70021 Da
Subunit: Interacts with ZNF541. Component of the CatSper complex (By similarity). Interacts with RABL2/RABL2A;
binds preferentially to GTP-bound RABL2 (By similarity)
2 PDB 3D structures from and Proteopedia for HSPA2:
3I33 (3D)        4FSV (3D)    
Secondary accessions: Q15508 Q53XM3 Q9UE78

Explore the universe of human proteins at neXtProt for HSPA2: NX_P54652

Explore proteomics data for HSPA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys109, Lys188, Lys348, Lys351, Lys360, Lys454, Lys510
  • Modification sites at PhosphoSitePlus

  • See HSPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068814.2  
    ENSEMBL proteins: 
     ENSP00000378199   ENSP00000247207  
    Reactome Protein details: P54652

    HSPA2 Human Recombinant Protein Products:

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    OriGene Purified Protein for HSPA2
    OriGene Protein Over-expression Lysate for HSPA2
    OriGene MassSpec for HSPA2
    OriGene Custom Protein Services for HSPA2
    GenScript Custom Purified and Recombinant Proteins Services for HSPA2
    Novus Biologicals HSPA2 Protein
    Novus Biologicals HSPA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSPA2

    HSPA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA2
    R&D Systems Antibodies for HSPA2
    OriGene Antibodies for HSPA2
    OriGene Custom Antibody Services for HSPA2
    Novus Biologicals HSPA2 Antibodies
    Abcam antibodies for HSPA2
    Cloud-Clone Corp. Antibodies for HSPA2
    ThermoFisher Antibody for HSPA2
    LSBio Antibodies in human, mouse, rat for HSPA2

    HSPA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HSPA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPA2
    Cloud-Clone Corp. CLIAs for HSPA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P54652

    ProtoNet protein and cluster: P54652

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP72_HUMAN, P54652
    Similarity: Belongs to the heat shock protein 70 family


    HSPA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP72_HUMAN, P54652
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage

         Genatlas biochemistry entry for HSPA2:
    heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohn's disease

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding TAS3037489
    GO:0051861glycolipid binding IEA--
         
    HSPA2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hspa2):
     endocrine/exocrine gland  reproductive system 

    HSPA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hspa2tm1Dix for HSPA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA2:
    hsa-mir-215-5p (MIRT024730), hsa-mir-192-5p (MIRT026895), hsa-mir-877-3p (MIRT036912)

    Block miRNA regulation of human, mouse, rat HSPA2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HSPA2:
    hsa-miR-4311 hsa-miR-1271 hsa-miR-371-5p hsa-miR-382 hsa-miR-19b hsa-miR-3143 hsa-miR-96 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSPA2
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA2

    Clone
    Products:
         
    OriGene clones in human, mouse for HSPA2 (see all 8)
    OriGene ORF clones in mouse, rat for HSPA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA2 (NM_021979)
    Sino Biological Human cDNA Clone for HSPA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSPA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol3
    mitochondrion2
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex IEA--
    GO:0001673male germ cell nucleus IEA--
    GO:0005739mitochondrion IEA--
    GO:0009986cell surface IEA--
    GO:0036128CatSper complex ISS--

    HSPA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA2 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    4Influenza A
    Influenza A0.34
    Measles0.34
    5Cell Cycle, Mitotic
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HSPA2 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA2
        Parkin-Ubiquitin Proteasomal System pathway


    3 Reactome Pathways for HSPA2
        Regulation of HSF1-mediated heat shock response
    Meiotic synapsis
    Attenuation phase


    Selected Kegg Pathways  (Kegg details for HSPA2) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA2 (P546521, 2, 3 ENSP000002472074) via UniProtKB, MINT, STRING, and/or I2D (see all 223)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEOX2P502222, 3, ENSP000002620414MINT-2860884 I2D: score=3 STRING: ENSP00000262041
    RIPK2O433532, 3MINT-49058 I2D: score=2 
    TAB2Q9NYJ82, 3MINT-49186 I2D: score=2 
    PSMA3P257882, 3MINT-4050722 I2D: score=1 
    HSPBP1Q9NZL41, 2, 3, ENSP000002556314EBI-356991,EBI-356763 MINT-2871513 MINT-66487 I2D: score=5 STRING: ENSP00000255631
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0006986response to unfolded protein TAS7829106
    GO:0007140male meiosis TAS8622925
    GO:0007141male meiosis I IEA--

    HSPA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA2 (HSP72)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSPA2 gene: 
    NM_021979.3  

    Unigene Cluster for HSPA2:

    Heat shock 70kDa protein 2
    Hs.432648  [show with all ESTs]
    Unigene Representative Sequence: NM_021979
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394709(uc001xhj.3) ENST00000554883 ENST00000247207(uc001xhk.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat HSPA2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HSPA2:
    hsa-miR-4311 hsa-miR-1271 hsa-miR-371-5p hsa-miR-382 hsa-miR-19b hsa-miR-3143 hsa-miR-96 hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSPA2
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA2
    Clone
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    OriGene clones in human, mouse for HSPA2 (see all 8)
    OriGene ORF clones in mouse, rat for HSPA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA2 (NM_021979)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSPA2
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA2
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA2
      QuantiFast Probe-based Assays in human, mouse, rat HSPA2

    Additional mRNA sequence: 

    AK097824.1 BC001752.1 BC034365.1 BC036107.1 BT009815.1 

    12 DOTS entries:

    DT.100026736  DT.91785830  DT.101983142  DT.120759401  DT.100689865  DT.100878670  DT.95365758  DT.100675724 
    DT.100878669  DT.120759371  DT.120759393  DT.92334502 

    Selected AceView cDNA sequences (see all 243):

    CR601466 BM471796 BX326156 BP372586 BP374622 BU188162 F03817 CD653825 
    BU752272 CB152018 BQ440635 CR596961 BQ670728 BT009815 AL040891 AW571906 
    CD299958 CN482552 AL046354 BP373114 BX347141 AU279621 AI580818 BX381080 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
    SP1:        -     -                                                               
    SP2:              -                                                               
    SP3:                          -     -     -                                       
    SP4:                                -     -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for HSPA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATTTGTT
    HSPA2 Expression
    About this image


    HSPA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             XY Germ Cells Testis Cord
             Seminiferous Tubules
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Gonad
             XY Germ Cells Testis Cord
     
     Eye (Sensory Organs)
             Retina
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    HSPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432648
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA2: 
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPA2
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA2
    QuantiTect SYBR Green Assays in human, mouse, rat HSPA2
    QuantiFast Probe-based Assays in human, mouse, rat HSPA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa21 , 5 heat shock protein 21, 5 92.2(n)1
    99.51(a)1
      12 (33.73 cM)5
    155121  NM_008301.41  NP_032327.21 
     764041765 
    chicken
    (Gallus gallus)
    Aves HSPA21 heat shock 70kDa protein 2 81.08(n)
    92.52(a)
      423504  NM_001006685.1  NP_001006686.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA26
    heat shock 70kDa protein 2
    92(a)
    1 ↔ 1
    1(1380946-1382853)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hspa21 heat shock 70kDa protein 2 78.97(n)
    87.97(a)
      100496396  XM_004917204.1  XP_004917261.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsp70l6
    heat shock cognate 70-kd protein, like
    82(a)
    many ↔ many
    8(5006699-5009452) ENSDARG00000055723
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43 neurotransmitter secretion chaperone 83(a)
    (best of 11)
      88E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSB2(YNL209W)4 Cytoplasmic ATPase that is a ribosome-associated molecular more   --   14(252059-253900) 855512  NP_014190.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ERD21 ERD2 65.68(n)
    74.55(a)
      842094  NM_104519.1  NP_176036.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.245152 Triticum aestivum 70 kDa heat shock protein (TaHSP7 more 82.78(n)    AF005993.1 


    ENSEMBL Gene Tree for HSPA2 (if available)
    TreeFam Gene Tree for HSPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA2 gene
    HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA142  HSPA1A2  
    15 SIMAP similar genes for HSPA2 using alignment to 1 protein entry:     HSP72_HUMAN:
    HSPA1B    HSPA1L    HSPA1A    HSP70-1    HSPA6    HSPA8
    HSPA7    LOC401308    HSPA5    HSPA9    HSPA14    HS24/p52
    HSPA13    HSPA4L    HSPA4

    HSPA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA2 (see all 158)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs43137341,2
    C,F,A,H--65005228(+) CACAAT/CCTATG 1 -- us2k125Minor allele frequency- C:0.36NS EA NA WA 2526
    rs1473989931,2
    --65005233(+) CCTATA/GTAAAG 1 -- us2k10--------
    rs1396980441,2
    --65005244(+) AATGGC/TTTTCC 1 -- us2k10--------
    rs455640311,2
    C,F--65005317(+) AGCAAC/TGCACT 1 -- us2k16Minor allele frequency- T:0.01NS NA 186
    rs455110971,2
    C,F--65005318(+) GCAACG/ACACTT 1 -- us2k17Minor allele frequency- A:0.05NS NA 306
    rs1846341221,2
    --65005466(+) TAGTAA/GGTACC 1 -- us2k10--------
    rs1471584181,2
    --65005551(+) TCCTGA/GAGACC 1 -- us2k10--------
    rs1404038011,2
    --65005558(+) GACCAC/TTTATT 1 -- us2k10--------
    rs1886718561,2
    --65005561(+) CATTTA/GTTTTA 1 -- us2k10--------
    rs454587951,2
    C,F--65005590(+) TCGTTC/GTGTCG 1 -- us2k15Minor allele frequency- G:0.01NS 184

    HapMap Linkage Disequilibrium report for HSPA2 (65002623 - 65009955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSPA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748779CNV Deletion23290073
    nsv1308CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140560    OMIM disorders: --

    Selected diseases for HSPA2 (see all 29):    
    About MalaCards
    legionellosis    visceral leishmaniasis    varicocele    h. pylori infection
    toxoplasmosis    leishmaniasis    septic shock    ankylosing spondylitis
    spondylitis    measles    peptic ulcer    male infertility
    crohn's disease    infertility    ulcerative colitis    sepsis
    pneumonia    inflammatory bowel disease    systemic lupus erythematosus    influenza

    1 disease from the University of Copenhagen DISEASES database for HSPA2:
    Male infertility

    HSPA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HSPA2
    Human Genome Epidemiology (HuGE) Navigator: HSPA2 (16 documents)

    Export disorders for HSPA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA2 gene, integrated from 10 sources (see all 97):
    (articles sorted by number of sources associating them with HSPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. (PubMed id 18813331)1, 4 Konings A....Van Camp G. (Eur. J. Hum. Genet. 2009)
    2. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (PubMed id 19661373)1, 4 Tahara T....Hirata I. (Anticancer Res. 2009)
    3. HLA-association of serum levels of natural antibodies. (PubMed id 19167759)1, 4 Pozsonyi E....FA1st G. (Mol. Immunol. 2009)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis. (PubMed id 17940904)1, 4 Lee S.H....Yoon Y.B. (Dig. Dis. Sci. 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. Heat shock protein gene 70-2 polymorphism is differentially associated with the clinical phenotypes of ulcerative colitis and Crohn's disease. (PubMed id 17532782)1, 4 Nam S.Y....Song I.S. (J. Gastroenterol. Hepatol. 2007)
    8. [The heat shock protein 70-2 gene +1267(A/G) polymorphism and susceptibility to ankylosing spondylitis in Chinese Han population]. (PubMed id 17922431)1, 4 Lin J.A....Chen R.Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    9. [Influence of alleles and haplotypes of the main histocompatibility complex on the susceptibility to systemic lupus erythematosus in the Mexican population]. (PubMed id 16875346)1, 4 Granados J....Vargas-AlarcA^n G. (Gac Med Mex 2006)
    10. Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers. (PubMed id 17009596)1, 4 Yang M....Wu T. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3306 HGNC: 5235 AceView: HSPA2 Ensembl:ENSG00000126803 euGenes: HUgn3306
    ECgene: HSPA2 Kegg: 3306 H-InvDB: HSPA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA2 gene:
    Search GeneIP for patents involving HSPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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