Aliases for HSPA2 Gene
External Ids for HSPA2 Gene
Previous GeneCards Identifiers for HSPA2 Gene
GeneCards Summary for HSPA2 Gene
HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Varicocele. Among its related pathways are Cellular response to heat stress and HSF1-dependent transactivation. GO annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA5.
UniProtKB/Swiss-Prot for HSPA2 Gene
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells.