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Aliases for HSPA2 Gene

Aliases for HSPA2 Gene

  • Heat Shock 70kDa Protein 2 2 3
  • Heat Shock 70kD Protein 2 2 3
  • Heat Shock-Related 70 KDa Protein 2 3
  • Heat Shock 70 KDa Protein 2 4
  • HSP70-2 3
  • HSP70-3 3

External Ids for HSPA2 Gene

Previous GeneCards Identifiers for HSPA2 Gene

  • GC14P062330
  • GC14P058796
  • GC14P062992
  • GC14P064072
  • GC14P065002
  • GC14P045179

Summaries for HSPA2 Gene

GeneCards Summary for HSPA2 Gene

HSPA2 (Heat Shock 70kDa Protein 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Cell Cycle, Mitotic. GO annotations related to this gene include unfolded protein binding and glycolipid binding. An important paralog of this gene is HSPA14.

UniProtKB/Swiss-Prot for HSPA2 Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage

Gene Wiki entry for HSPA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA2 Gene

Genomics for HSPA2 Gene

Regulatory Elements for HSPA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA2 Gene

Start:
64,535,905 bp from pter
End:
64,546,173 bp from pter
Size:
10,269 bases
Orientation:
Plus strand

Genomic View for HSPA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA2 Gene

Proteins for HSPA2 Gene

  • Protein details for HSPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54652-HSP72_HUMAN
    Recommended name:
    Heat shock-related 70 kDa protein 2
    Protein Accession:
    P54652
    Secondary Accessions:
    • Q15508
    • Q53XM3
    • Q9UE78

    Protein attributes for HSPA2 Gene

    Size:
    639 amino acids
    Molecular mass:
    70021 Da
    Quaternary structure:
    • Interacts with ZNF541. Component of the CatSper complex (By similarity). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with FKBP6.

    Three dimensional structures from OCA and Proteopedia for HSPA2 Gene

neXtProt entry for HSPA2 Gene

Proteomics data for HSPA2 Gene at MOPED

Post-translational modifications for HSPA2 Gene

  • Ubiquitination at Lys109, Lys188, Lys348, Lys351, Lys360, Lys454, and Lys510
  • Modification sites at PhosphoSitePlus

Other Protein References for HSPA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA2 Gene

Domains for HSPA2 Gene

Gene Families for HSPA2 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA2 Gene

Graphical View of Domain Structure for InterPro Entry

P54652

UniProtKB/Swiss-Prot:

HSP72_HUMAN :
  • P54652
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA2: view

Function for HSPA2 Gene

Molecular function for HSPA2 Gene

GENATLAS Biochemistry: heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohns disease
UniProtKB/Swiss-Prot Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage

Gene Ontology (GO) - Molecular Function for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0019899 enzyme binding IPI 23921388
GO:0051082 unfolded protein binding IDA 21231916
GO:0051861 glycolipid binding IEA --
genes like me logo Genes that share ontologies with HSPA2: view

Phenotypes for HSPA2 Gene

genes like me logo Genes that share phenotypes with HSPA2: view

Animal Models for HSPA2 Gene

MGI Knock Outs for HSPA2:

Animal Model Products

CRISPR Products

miRNA for HSPA2 Gene

miRTarBase miRNAs that target HSPA2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSPA2 Gene

Localization for HSPA2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA2 Gene COMPARTMENTS Subcellular localization image for HSPA2 gene
Compartment Confidence
plasma membrane 4
cytosol 3
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IEA --
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with HSPA2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA2 Gene

Pathways for HSPA2 Gene

genes like me logo Genes that share pathways with HSPA2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0001934 positive regulation of protein phosphorylation --
GO:0006986 response to unfolded protein TAS 7829106
GO:0007140 male meiosis TAS 8622925
GO:0007141 male meiosis I IEA --
genes like me logo Genes that share ontologies with HSPA2: view

Transcripts for HSPA2 Gene

mRNA/cDNA for HSPA2 Gene

Unigene Clusters for HSPA2 Gene

Heat shock 70kDa protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for HSPA2 Gene

GeneLoc Exon Structure for
HSPA2
ECgene alternative splicing isoforms for
HSPA2

Expression for HSPA2 Gene

mRNA expression in normal human tissues for HSPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA2 Gene

SOURCE GeneReport for Unigene cluster for HSPA2 Gene Hs.432648

genes like me logo Genes that share expressions with HSPA2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HSPA2 Gene

Orthologs for HSPA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA2 35
  • 99.78 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HSPA2 35
  • 92.73 (n)
  • 98.2 (a)
dog
(Canis familiaris)
Mammalia HSPA2 35
  • 93.88 (n)
  • 99.51 (a)
HSPA2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa2 35
  • 92.2 (n)
  • 99.51 (a)
Hspa2 16
Hspa2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa2 35
  • 91.44 (n)
  • 99.19 (a)
chicken
(Gallus gallus)
Aves HSP70 36
  • 93 (a)
OneToOne
HSPA2 35
  • 81.08 (n)
  • 92.52 (a)
lizard
(Anolis carolinensis)
Reptilia HSPA2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa2 35
  • 78.97 (n)
  • 87.97 (a)
zebrafish
(Danio rerio)
Actinopterygii hsp70l 36
  • 82 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 36
  • 79 (a)
ManyToMany
Hsc70-4 36
  • 81 (a)
ManyToMany
Hsc70-4 37
  • 83 (a)
Hsc70-3 37
  • 62 (a)
Hsp70Aa 37
  • 75 (a)
Hsc70-1 37
  • 80 (a)
Hsp70Bb 37
  • 74 (a)
Hsp70Bc 37
  • 74 (a)
Hsc70-2 37
  • 71 (a)
Hsp68 37
  • 71 (a)
Hsp70Ba 37
  • 74 (a)
CG7182 37
  • 25 (a)
Hsp70Ab 37
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36
  • 82 (a)
OneToMany
F44E5.4 37
  • 68 (a)
hsp-70 37
  • 67 (a)
F44E5.5 37
  • 68 (a)
hsp-3 37
  • 61 (a)
hsp-1 37
  • 83 (a)
hsp-4 37
  • 59 (a)
hsp-2 37
  • 77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 72 (a)
OneToMany
SSB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ERD2 35
  • 65.68 (n)
  • 74.55 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24515 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 80 (a)
ManyToMany
CSA.971 36
  • 76 (a)
ManyToMany
Species with no ortholog for HSPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSPA2 Gene

ENSEMBL:
Gene Tree for HSPA2 (if available)
TreeFam:
Gene Tree for HSPA2 (if available)

Paralogs for HSPA2 Gene

Paralogs for HSPA2 Gene

Selected SIMAP similar genes for HSPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA2: view

Variants for HSPA2 Gene

Sequence variations from dbSNP and Humsavar for HSPA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3213995 -- 64,542,932(+) ATAAA(A/C)GTTCC utr-variant-3-prime
rs3213996 -- 64,543,023(+) AGTTC(A/G)TGCAT utr-variant-3-prime
rs11551976 -- 64,542,502(-) TTGAT(A/C/G)TTGTA reference, missense, synonymous-codon
rs11551978 -- 64,542,783(-) CGCTG(A/G)CTTGA utr-variant-3-prime
rs11551979 -- 64,542,935(-) TTTGG(A/G)ACTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPA2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv1308 CNV Insertion 18451855

Relevant External Links for HSPA2 Gene

HapMap Linkage Disequilibrium report
HSPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA2 Gene

Disorders for HSPA2 Gene

(1) University of Copenhagen DISEASES for HSPA2 Gene

Relevant External Links for HSPA2

Genetic Association Database (GAD)
HSPA2
Human Genome Epidemiology (HuGE) Navigator
HSPA2
genes like me logo Genes that share disorders with HSPA2: view

No data available for UniProtKB/Swiss-Prot for HSPA2 Gene

Publications for HSPA2 Gene

  1. Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2). (PMID: 7829106) Bonnycastle L.L.C. … Schellenberg G.D. (Genomics 1994) 3 4
  2. A heat shock gene at 14q22: mapping and expression. (PMID: 7849706) Roux A.-F. … Cox D.W. (Hum. Mol. Genet. 1994) 3 4
  3. Genetic factors determine extent of bone loss in inflammatory bowel disease. (PMID: 11040178) Schulte C.M. … Schulte K.M. (Gastroenterology 2000) 3 48
  4. Lack of association between the polymorphism at the heat-shock protein (HSP70-2) gene and systemic lupus erythematosus (SLE) in the Mexican mestizo population. (PMID: 11196683) Vargas-AlarcA^n G. … Arnaiz-Villena A. (Genes Immun. 2000) 3 48
  5. Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis. (PMID: 11334675) Meddeb-Garnaoui A. … Dellagi K. (Hum. Immunol. 2001) 3 48

Products for HSPA2 Gene

  • Addgene plasmids for HSPA2

Sources for HSPA2 Gene

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