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Aliases for HSPA2 Gene

Aliases for HSPA2 Gene

  • Heat Shock Protein Family A (Hsp70) Member 2 2 3 5
  • Heat Shock 70kDa Protein 2 2 3
  • Heat Shock 70kD Protein 2 2 3
  • Heat Shock-Related 70 KDa Protein 2 3
  • Heat Shock 70 KDa Protein 2 4
  • HSP70-2 3
  • HSP70-3 3

External Ids for HSPA2 Gene

Previous GeneCards Identifiers for HSPA2 Gene

  • GC14P062330
  • GC14P058796
  • GC14P062992
  • GC14P064072
  • GC14P065002
  • GC14P045179

Summaries for HSPA2 Gene

GeneCards Summary for HSPA2 Gene

HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Varicocele and Inflammatory Bowel Disease 3. Among its related pathways are mRNA Splicing - Major Pathway and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot for HSPA2 Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene Wiki entry for HSPA2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA2 Gene

Genomics for HSPA2 Gene

Regulatory Elements for HSPA2 Gene

Enhancers for HSPA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G064628 1 Ensembl ENCODE 23.6 +93.2 93154 1.9 CTCF ESRRA SIN3A BMI1 TCF12 ZNF766 FOS PRDM10 SMARCE1 RFX1 HSPA2 PPP1R36 ZBTB1 GC14P064620 PLEKHG3
GH14G064499 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -31.2 -31155 9.9 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 LOC102723809 ZBTB1 PPP1R36 AKAP5 HSPA2 TEX21P ENSG00000214770 ZBTB25
GH14G064610 0.9 Ensembl ENCODE 22.3 +75.9 75850 2.5 JUN NR2F2 YY1 FOXA1 JUND GATA3 NFE2 FOS MAFK SP7 HSPA2 PPP1R36 GC14P064620 NUP50P1
GH14G064636 1.2 Ensembl ENCODE 12.6 +101.2 101205 1.5 SIN3A YY1 GLIS2 ZNF143 KLF7 KLF13 SP3 KAT8 ZNF592 SREBF1 HSPA2 GC14P064620 PLEKHG3
GH14G064638 1.2 Ensembl ENCODE 12.6 +104.3 104260 4.3 FOXA2 CBX3 PKNOX1 TBL1XR1 ARNT BMI1 RAD21 YY1 TCF12 GATA2 HSPA2 GC14P064620 PLEKHG3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA2 Gene

Chromosome:
14
Start:
64,535,905 bp from pter
End:
64,546,173 bp from pter
Size:
10,269 bases
Orientation:
Plus strand

Genomic View for HSPA2 Gene

Genes around HSPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA2 Gene

Proteins for HSPA2 Gene

  • Protein details for HSPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54652-HSP72_HUMAN
    Recommended name:
    Heat shock-related 70 kDa protein 2
    Protein Accession:
    P54652
    Secondary Accessions:
    • Q15508
    • Q53XM3
    • Q9UE78

    Protein attributes for HSPA2 Gene

    Size:
    639 amino acids
    Molecular mass:
    70021 Da
    Quaternary structure:
    • Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity). Interacts with FKBP6 (PubMed:18529014).

    Three dimensional structures from OCA and Proteopedia for HSPA2 Gene

neXtProt entry for HSPA2 Gene

Post-translational modifications for HSPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA2 Gene

Domains & Families for HSPA2 Gene

Gene Families for HSPA2 Gene

Protein Domains for HSPA2 Gene

Graphical View of Domain Structure for InterPro Entry

P54652

UniProtKB/Swiss-Prot:

HSP72_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA2: view

Function for HSPA2 Gene

Molecular function for HSPA2 Gene

GENATLAS Biochemistry:
heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohns disease
UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Gene Ontology (GO) - Molecular Function for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0019899 enzyme binding IPI 23921388
GO:0051082 unfolded protein binding IDA,TAS 21231916
GO:0097718 disordered domain specific binding IPI 15914229
genes like me logo Genes that share ontologies with HSPA2: view
genes like me logo Genes that share phenotypes with HSPA2: view

Animal Models for HSPA2 Gene

MGI Knock Outs for HSPA2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA2 Gene

Localization for HSPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA2 Gene

Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250 UniProtKB:P17156}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA 21231916
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with HSPA2: view

Pathways & Interactions for HSPA2 Gene

genes like me logo Genes that share pathways with HSPA2: view

SIGNOR curated interactions for HSPA2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 7829106
GO:0007140 male meiosis TAS 8622925
GO:0007283 spermatogenesis ISS --
GO:0007286 spermatid development TAS 8622925
GO:0009408 response to heat ISS --
genes like me logo Genes that share ontologies with HSPA2: view

Drugs & Compounds for HSPA2 Gene

No Compound Related Data Available

Transcripts for HSPA2 Gene

mRNA/cDNA for HSPA2 Gene

Unigene Clusters for HSPA2 Gene

Heat shock 70kDa protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSPA2

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for HSPA2 Gene

GeneLoc Exon Structure for
HSPA2
ECgene alternative splicing isoforms for
HSPA2

Expression for HSPA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.8).

Protein differential expression in normal tissues from HIPED for HSPA2 Gene

This gene is overexpressed in Brain (8.4) and Spinal cord (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of HSPA2 Gene:

HSPA2

SOURCE GeneReport for Unigene cluster for HSPA2 Gene:

Hs.432648

Evidence on tissue expression from TISSUES for HSPA2 Gene

  • Nervous system(5)
  • Eye(4.4)
  • Kidney(3.2)
  • Skin(2.5)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with HSPA2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA2 Gene

Orthologs for HSPA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA2 34
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA2 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA2 34 35
  • 93.88 (n)
cow
(Bos Taurus)
Mammalia HSPA2 34
  • 92.73 (n)
mouse
(Mus musculus)
Mammalia Hspa2 16 35 34
  • 92.2 (n)
rat
(Rattus norvegicus)
Mammalia Hspa2 34
  • 91.44 (n)
chicken
(Gallus gallus)
Aves HSP70 35
  • 93 (a)
OneToOne
HSPA2 34
  • 81.08 (n)
lizard
(Anolis carolinensis)
Reptilia HSPA2 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa2 34
  • 78.97 (n)
zebrafish
(Danio rerio)
Actinopterygii hsp70l 35
  • 82 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 36 35
  • 83 (a)
Hsc70-1 36 35
  • 80 (a)
Hsp70Aa 36
  • 75 (a)
Hsp70Ab 36
  • 75 (a)
Hsp70Ba 36
  • 74 (a)
Hsp70Bb 36
  • 74 (a)
Hsp70Bc 36
  • 74 (a)
Hsc70-2 36
  • 71 (a)
Hsp68 36
  • 71 (a)
Hsc70-3 36
  • 62 (a)
CG7182 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36 35
  • 83 (a)
hsp-2 36
  • 77 (a)
F44E5.4 36
  • 68 (a)
F44E5.5 36
  • 68 (a)
hsp-70 36
  • 67 (a)
hsp-3 36
  • 61 (a)
hsp-4 36
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 35
  • 72 (a)
OneToMany
SSB1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons ERD2 34
  • 65.68 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.24515 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 35
  • 80 (a)
ManyToMany
CSA.971 35
  • 76 (a)
ManyToMany
Species where no ortholog for HSPA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSPA2 Gene

ENSEMBL:
Gene Tree for HSPA2 (if available)
TreeFam:
Gene Tree for HSPA2 (if available)

Paralogs for HSPA2 Gene

Paralogs for HSPA2 Gene

(15) SIMAP similar genes for HSPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA2: view

Variants for HSPA2 Gene

Sequence variations from dbSNP and Humsavar for HSPA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000287320 -- 64,539,846(+) CCAGC(A/T)AATTT intron-variant, upstream-variant-2KB
rs1001860111 -- 64,538,832(+) CTCCT(G/T)GAGAC intron-variant, upstream-variant-2KB
rs1004478522 -- 64,540,093(+) TCCCC(A/G)TCCAA intron-variant, upstream-variant-2KB
rs1005246529 -- 64,543,227(+) TGAAA(C/T)TGATC utr-variant-3-prime
rs1006085493 -- 64,539,244(+) GTTTA(G/T)GCCTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPA2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV deletion 23290073
nsv1308 CNV insertion 18451855

Variation tolerance for HSPA2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA2 Gene

Human Gene Mutation Database (HGMD)
HSPA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA2 Gene

Disorders for HSPA2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSPA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
varicocele
  • scrotal varices
inflammatory bowel disease 3
  • ibd3
- elite association - COSMIC cancer census association via MalaCards
Search HSPA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA2

Genetic Association Database (GAD)
HSPA2
Human Genome Epidemiology (HuGE) Navigator
HSPA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA2
genes like me logo Genes that share disorders with HSPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA2 Gene

Publications for HSPA2 Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 3 4 64
  2. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. (PMID: 18813331) Konings A. … Van Camp G. (Eur. J. Hum. Genet. 2009) 3 46 64
  3. HLA-association of serum levels of natural antibodies. (PMID: 19167759) Pozsonyi E. … FA1st G. (Mol. Immunol. 2009) 3 46 64
  4. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (PMID: 19661373) Tahara T. … Hirata I. (Anticancer Res. 2009) 3 46 64
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64

Products for HSPA2 Gene

  • Addgene plasmids for HSPA2

Sources for HSPA2 Gene

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