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Aliases for HSPA2 Gene

Aliases for HSPA2 Gene

  • Heat Shock Protein Family A (Hsp70) Member 2 2 3 5
  • Heat Shock 70kDa Protein 2 2 3
  • Heat Shock 70kD Protein 2 2 3
  • Heat Shock 70 KDa Protein 2 4
  • HSP70-2 3
  • HSP70-3 3

External Ids for HSPA2 Gene

Previous GeneCards Identifiers for HSPA2 Gene

  • GC14P062330
  • GC14P058796
  • GC14P062992
  • GC14P064072
  • GC14P065002
  • GC14P045179

Summaries for HSPA2 Gene

GeneCards Summary for HSPA2 Gene

HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include varicocele. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA5.

UniProtKB/Swiss-Prot for HSPA2 Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells.

Gene Wiki entry for HSPA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA2 Gene

Genomics for HSPA2 Gene

Regulatory Elements for HSPA2 Gene

Genomic Location for HSPA2 Gene

Chromosome:
14
Start:
64,535,905 bp from pter
End:
64,546,173 bp from pter
Size:
10,269 bases
Orientation:
Plus strand

Genomic View for HSPA2 Gene

Genes around HSPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA2 Gene

Proteins for HSPA2 Gene

  • Protein details for HSPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54652-HSP72_HUMAN
    Recommended name:
    Heat shock-related 70 kDa protein 2
    Protein Accession:
    P54652
    Secondary Accessions:
    • Q15508
    • Q53XM3
    • Q9UE78

    Protein attributes for HSPA2 Gene

    Size:
    639 amino acids
    Molecular mass:
    70021 Da
    Quaternary structure:
    • Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity). Interacts with FKBP6 (PubMed:18529014).

    Three dimensional structures from OCA and Proteopedia for HSPA2 Gene

neXtProt entry for HSPA2 Gene

Proteomics data for HSPA2 Gene at MOPED

Post-translational modifications for HSPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA2 Gene

Domains & Families for HSPA2 Gene

Gene Families for HSPA2 Gene

Protein Domains for HSPA2 Gene

Graphical View of Domain Structure for InterPro Entry

P54652

UniProtKB/Swiss-Prot:

HSP72_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA2: view

Function for HSPA2 Gene

Molecular function for HSPA2 Gene

GENATLAS Biochemistry:
heat shock protein A2,acting as a molecular chaperone putative,marker of benign evolution of Crohns disease
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells.
genes like me logo Genes that share phenotypes with HSPA2: view

Animal Models for HSPA2 Gene

MGI Knock Outs for HSPA2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA2 Gene

Localization for HSPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA2 Gene

Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with SHCBP1L at spindle during the meiosis process. {ECO:0000250 UniProtKB:P17156}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA2 Gene COMPARTMENTS Subcellular localization image for HSPA2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 5
plasma membrane 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005829 cytosol IDA 21231916
GO:0016020 membrane IDA 19946888
GO:0036128 CatSper complex ISS --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with HSPA2: view

Pathways & Interactions for HSPA2 Gene

genes like me logo Genes that share pathways with HSPA2: view

SIGNOR curated interactions for HSPA2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HSPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 7829106
GO:0007140 male meiosis TAS 8622925
GO:0007286 spermatid development IEA --
GO:0009408 response to heat ISS --
GO:0009409 response to cold ISS --
genes like me logo Genes that share ontologies with HSPA2: view

Drugs & Compounds for HSPA2 Gene

No Compound Related Data Available

Transcripts for HSPA2 Gene

mRNA/cDNA for HSPA2 Gene

Unigene Clusters for HSPA2 Gene

Heat shock 70kDa protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5:
SP6: - - -

Relevant External Links for HSPA2 Gene

GeneLoc Exon Structure for
HSPA2
ECgene alternative splicing isoforms for
HSPA2

Expression for HSPA2 Gene

mRNA expression in normal human tissues for HSPA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.8).

Protein differential expression in normal tissues from HIPED for HSPA2 Gene

This gene is overexpressed in Brain (8.4) and Spinal cord (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA2 Gene



SOURCE GeneReport for Unigene cluster for HSPA2 Gene Hs.432648

genes like me logo Genes that share expression patterns with HSPA2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HSPA2 Gene

Orthologs for HSPA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA2 35
  • 99.78 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HSPA2 35
  • 92.73 (n)
  • 98.2 (a)
dog
(Canis familiaris)
Mammalia HSPA2 35
  • 93.88 (n)
  • 99.51 (a)
HSPA2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa2 36
  • 99 (a)
OneToOne
Hspa2 16
Hspa2 35
  • 92.2 (n)
  • 99.51 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA2 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa2 35
  • 91.44 (n)
  • 99.19 (a)
chicken
(Gallus gallus)
Aves HSP70 36
  • 93 (a)
OneToOne
HSPA2 35
  • 81.08 (n)
  • 92.52 (a)
lizard
(Anolis carolinensis)
Reptilia HSPA2 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa2 35
  • 78.97 (n)
  • 87.97 (a)
zebrafish
(Danio rerio)
Actinopterygii hsp70l 36
  • 82 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 36
  • 79 (a)
ManyToMany
Hsc70-4 36
  • 81 (a)
ManyToMany
CG7182 37
  • 25 (a)
Hsc70-1 37
  • 80 (a)
Hsc70-2 37
  • 71 (a)
Hsc70-3 37
  • 62 (a)
Hsc70-4 37
  • 83 (a)
Hsp68 37
  • 71 (a)
Hsp70Aa 37
  • 75 (a)
Hsp70Ab 37
  • 75 (a)
Hsp70Ba 37
  • 74 (a)
Hsp70Bb 37
  • 74 (a)
Hsp70Bc 37
  • 74 (a)
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 68 (a)
F44E5.5 37
  • 68 (a)
hsp-1 37
  • 83 (a)
hsp-2 37
  • 77 (a)
hsp-3 37
  • 61 (a)
hsp-4 37
  • 59 (a)
hsp-70 37
  • 67 (a)
hsp-1 36
  • 82 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 72 (a)
OneToMany
SSB2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ERD2 35
  • 65.68 (n)
  • 74.55 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.24515 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 80 (a)
ManyToMany
CSA.971 36
  • 76 (a)
ManyToMany
Species with no ortholog for HSPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSPA2 Gene

ENSEMBL:
Gene Tree for HSPA2 (if available)
TreeFam:
Gene Tree for HSPA2 (if available)

Paralogs for HSPA2 Gene

Paralogs for HSPA2 Gene

(15) SIMAP similar genes for HSPA2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA2: view

Variants for HSPA2 Gene

Sequence variations from dbSNP and Humsavar for HSPA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3213996 -- 64,543,023(+) AGTTC(A/G)TGCAT utr-variant-3-prime
rs11551976 -- 64,542,502(-) TTGAT(A/C/G)TTGTA reference, synonymous-codon
rs11551978 -- 64,542,783(-) CGCTG(A/G)CTTGA utr-variant-3-prime
rs11551979 -- 64,542,935(-) TTTGG(A/G)ACTTT utr-variant-3-prime
rs11848114 -- 64,543,642(+) AGAGA(C/G)AGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSPA2 Gene

Variant ID Type Subtype PubMed ID
esv2748779 CNV Deletion 23290073
nsv1308 CNV Insertion 18451855

Variation tolerance for HSPA2 Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA2 Gene

HapMap Linkage Disequilibrium report
HSPA2
Human Gene Mutation Database (HGMD)
HSPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA2 Gene

Disorders for HSPA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
varicocele
  • scrotal varices
- elite association - COSMIC cancer census association via MalaCards
Search HSPA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSPA2

Genetic Association Database (GAD)
HSPA2
Human Genome Epidemiology (HuGE) Navigator
HSPA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA2
genes like me logo Genes that share disorders with HSPA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA2 Gene

Publications for HSPA2 Gene

  1. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. (PMID: 23921388) Jakobsson M.E. … Falnes P.A.9. (J. Biol. Chem. 2013) 3 4 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for HSPA2 Gene

Sources for HSPA2 Gene

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