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HSPA1L Gene

protein-coding   GIFtS: 64
GCID: GC06M031777

Heat Shock 70kDa Protein 1-Like

(Previous name: heat shock 70kD protein-like 1)
  See HSPA1L-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 1-Like1 2     HSP70T2
Heat Shock 70kD Protein-Like 11 2     Heat Shock 10kDa Protein 1-Like2
Heat Shock 70 KDa Protein 1-Hom2 3     Heat Shock 70 KDa Protein 1-Like2
Heat Shock 70 KDa Protein 1L2 3     hum70t2
HSP70-1L2     HSP70-Hom3
HSP70-HOM2     

External Ids:    HGNC: 52341   Entrez Gene: 33052   Ensembl: ENSG000002043907   OMIM: 1405595   UniProtKB: P349313   

Export aliases for HSPA1L gene to outside databases

Previous GC identifers: GC06M031849 GC06M031548 GC06M031881 GC06M031885 GC06M031563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA1L Gene:
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein
stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the
cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a
cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HSPA1L Gene:
HSPA1L (heat shock 70kDa protein 1-like) is a protein-coding gene. Diseases associated with HSPA1L include legionellosis, and abacavir hypersensitivity. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HS71L_HUMAN, P34931
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage (By similarity)

Gene Wiki entry for HSPA1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA1L gene promoter:
         Max1   PPAR-alpha   CP2   STAT3   NF-kappaB   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA1L promoter sequence
   Search Chromatin IP Primers for HSPA1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HSPA1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1L gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031777:  view genomic region     (about GC identifiers)

Start:
31,777,396 bp from pter      End:
31,783,437 bp from pter
Size:
6,042 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167248 3,071,044-3,076,482      Chr6-,NT_167245 3,062,983-3,068,422      Chr6-,NT_113891.2 3,286,977-3,292,415     
Chr6-,NT_167244 3,092,157-3,097,596     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HS71L_HUMAN, P34931 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1-like  
Size: 641 amino acids; 70375 Da
1 PDB 3D structure from and Proteopedia for HSPA1L:
3GDQ (3D)    
Secondary accessions: A6NNB0 B0UXW8 O75634 Q2HXR3 Q8NE72 Q96QC9 Q9UQM1

Explore the universe of human proteins at neXtProt for HSPA1L: NX_P34931

Explore proteomics data for HSPA1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys161, Lys363, Lys425, Lys453, Lys509, Lys514
  • Modification sites at PhosphoSitePlus

  • See HSPA1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005518.3  
    ENSEMBL proteins: 
     ENSP00000364805   ENSP00000387691  
    Reactome Protein details: P34931

    HSPA1L Human Recombinant Protein Products:

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    Novus Biologicals HSPA1L Proteins
    Novus Biologicals HSPA1L Lysates
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    Cloud-Clone Corp. Proteins for HSPA1L

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P34931

    ProtoNet protein and cluster: P34931

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HS71L_HUMAN, P34931
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS71L_HUMAN, P34931
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage (By similarity)
    Induction: Not induced by heat shock

         Genatlas biochemistry entry for HSPA1L:
    heat shock 70kDa protein A1-like 2,acting as a molecular chaperone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with HSPA1L           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPA1L
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA1L

    miRNA
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    miRTarBase miRNAs that target HSPA1L:
    hsa-mir-26b-5p (MIRT028894), hsa-mir-335-5p (MIRT016961), hsa-mir-193b-3p (MIRT041506)

    Block miRNA regulation of human, mouse, rat HSPA1L using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidHSPA1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA1L

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for HSPA1L (see all 6)
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    GenScript: all cDNA clones in your preferred vector: HSPA1L (NM_005527)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA1L
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    Addgene plasmids for HSPA1L 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002199zona pellucida receptor complex IEA--
    GO:0005739mitochondrion ----
    GO:0005759mitochondrial matrix IEA--
    GO:0008180colocalizes with COP9 signalosome IDA18850735
    GO:0044297cell body IEA--

    Find genes that share ontologies with HSPA1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA1L About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    3Influenza A
    Influenza A0.34
    Measles0.34
    4Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    5MAPK signaling pathway
    MAPK signaling pathway0.50


    Find genes that share SuperPaths with HSPA1L           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HSPA1L (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA1L
        Parkin-Ubiquitin Proteasomal System pathway

    3 Reactome Pathways for HSPA1L
        Regulation of HSF1-mediated heat shock response
    HSF1-dependent transactivation
    Attenuation phase


    Selected Kegg Pathways  (Kegg details for HSPA1L) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1L: 
              Telomeres & Telomerase in human mouse rat
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA1L (P349312, 3 ENSP000003648054) via UniProtKB, MINT, STRING, and/or I2D (see all 175)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3MINT-48693 MINT-48566 I2D: score=2 
    NFKB1P198382, 3MINT-48530 MINT-48639 I2D: score=1 
    TRAF2Q129332, 3MINT-49531 I2D: score=3 
    IKBKBO149202, 3MINT-48066 I2D: score=2 
    IKBKGQ9Y6K92, 3MINT-48131 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006986response to unfolded protein TAS9685725
    GO:0007339binding of sperm to zona pellucida IEA--

    Find genes that share ontologies with HSPA1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA1L (HS71L)

    1 PharmGKB related drug/compound annotation for HSPA1L gene    About this table
    Drug/compound PharmGKB Annotation
    carbamazepineCA  



    Find genes that share compounds with HSPA1L           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA1L gene: 
    NM_005527.3  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375654(uc003nxh.3 uc010jte.3) ENST00000417199
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA1L
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    Addgene plasmids for HSPA1L 
    Primer
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    OriGene qPCR primer pairs and template standards for HSPA1L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA1L
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA1L
      QuantiFast Probe-based Assays in human, mouse, rat HSPA1L

    Selected AceView cDNA sequences (see all 199):

    BE644616 CB148853 BU537924 BU682122 AA654107 CR542157 AA300649 CK300820 
    NM_005527 AI815737 BQ787081 CR542146 BE255486 CB134865 AI082376 BX111786 
    BI837918 AF196468 CB130115 AI800698 CR601536 AI815933 BM912100 AI265985 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPA1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCACCTAT
    HSPA1L Expression
    About this image


    HSPA1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testis Interstitium
    HSPA1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA1L Protein Expression

    UniProtKB/Swiss-Prot: HS71L_HUMAN, P34931
    Tissue specificity: Expressed in spermatids

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1L: 
              Telomeres & Telomerase in human mouse rat
              Cellular Stress Responses in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HSPA1L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA1L
    QuantiTect SYBR Green Assays in human, mouse, rat HSPA1L
    QuantiFast Probe-based Assays in human, mouse, rat HSPA1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA1L gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa1l1 , 5 heat shock protein 1-like1, 5 85.28(n)1
    94.7(a)1
      17 (18.51 cM)5
    154821  NM_013558.21  NP_038586.21 
     349727035 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    82(a)
    many ↔ many
    LGf(897907-924982)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-199o1.21 si:ch211-199o1.2 75.04(n)
    86.66(a)
      798846  NM_001100062.1  NP_001093532.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43 neurotransmitter secretion chaperone 82(a)
    (best of 11)
      88E4   --
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 80(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSA1(YAL005C)4
    SSA11
    ATPase involved in protein folding and nuclear localization more4
    SSA11
    64.66(n)1
    74.64(a)1
      1(141431-139503)4
    8512591, 4  NP_009396.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons Hsp70b1 Hsp70b 64.79(n)
    73.95(a)
      838174  NM_101471.2  NP_173055.1 


    ENSEMBL Gene Tree for HSPA1L (if available)
    TreeFam Gene Tree for HSPA1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA1L gene
    HSPA82  HSPA92  HSPA52  HSPA1B2  HSPA62  HSPA142  HSPA22  HSPA1A2  
    16 SIMAP similar genes for HSPA1L using alignment to 1 protein entry:     HS71L_HUMAN:
    HSP70-1    HSPA1B    HSPA1A    HSPA2    HSPA6    HSPA7
    LOC401308    HSPA8    HSPA5    HSPA9    HSPA14    HSPA13
    HS24/p52    HSPA4    HSPA4L    HSPH1

    Find genes that share paralogs with HSPA1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA1L (see all 152)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5524121,2
    C--31777077(+) GTAATC/TCCAGC 5 -- ds50012Minor allele frequency- T:0.25NA CSA 4
    rs131932801,2
    C,F--31777157(+) ACCCCG/ATCTCT 5 -- ds50012Minor allele frequency- A:0.50NA WA 4
    rs5534141,2
    C--31777192(+) cgggcA/Gtggtg 5 -- ds50010--------
    rs5403161,2
    C--31777199(+) ggtggC/Ggggcg 5 -- ds50010--------
    rs5403691,2
    C--31777213(+) gtagtC/Gccagc 5 -- ds50010--------
    rs1495038771,2
    C--31777214(+) CAGTCC/TCAGCT 1 -- ds50010--------
    rs1856873831,2
    C--31777247(+) AATGGC/TGTGAA 1 -- ds50010--------
    rs1904021121,2
    --31777290(+) TGTGCC/TACTGC 1 -- ds50010--------
    rs1440075011,2
    --31777502(+) ATACCA/GGAAGT 1 -- ut310--------
    rs1144065441,2
    C,F--31777602(+) AAATAC/TATCAC 5 -- ut311Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for HSPA1L (31777396 - 31783437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSPA1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6583n71CNV Loss21882294
    nsv823502CNV Loss20364138
    dgv6582n71CNV Loss21882294
    nsv823503CNV Loss20364138
    dgv6584n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HSPA1L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA1L
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140559    OMIM disorders: --

    6 diseases for HSPA1L:    
    About MalaCards
    legionellosis    abacavir hypersensitivity    diabetic foot ulcers    pulmonary edema
    visceral leishmaniasis    pneumoconiosis


    Find genes that share disorders with HSPA1L           About GenesLikeMe

    3 Novoseek inferred disease relationships for HSPA1L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 55.4 6 12544996 (1), 9461376 (1), 15963589 (1), 17175269 (1) (see all 6)
    necrosis 0 1 12544996 (1)
    tumors 0 1 12544996 (1)

    Genetic Association Database (GAD): HSPA1L
    Human Genome Epidemiology (HuGE) Navigator: HSPA1L (65 documents)

    Export disorders for HSPA1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA1L gene, integrated from 10 sources (see all 132):
    (articles sorted by number of sources associating them with HSPA1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. (PubMed id 9685725)1, 2, 3, 9 Ito Y.... Fujimoto H. (J. Biochem. 1998)
    2. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. (PubMed id 16525348)1, 4, 9 Bowers D.J....Lowry S.F. (Shock 2006)
    3. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)1, 4, 9 Pae C.U....Kim J.J. (Neurosci. Res. 2005)
    4. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. (PubMed id 12544996)1, 4, 9 SchrAPder O....Laun R.A. (Crit. Care Med. 2003)
    5. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. (PubMed id 19731315)1, 4, 9 Mir K.A....Ramakrishna B.S. (Br J Surg 2009)
    6. Heat-shock protein-70 genes and response to antidepressants in major depression. (PubMed id 17428599)1, 4, 9 Pae C.U....Paik I.H. (amp 2007)
    7. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PubMed id 19439993)1, 4, 9 Pae C.U....Serretti A. (Neuropsychobiology 2009)
    8. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PubMed id 19085089)1, 4, 9 Li J.X....Niu W.Q. (amp 2009)
    9. Synergistic effect and VEGF/HSP70-hom haplotype analysis: relationship to prostate cancer risk and clinical outcome. (PubMed id 20096741)1, 4 Sfar S....Chouchane L. (Hum. Immunol. 2010)
    10. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. (PubMed id 20498198)1, 4 FA1rnrohr B.G....Voll R.E. (Ann. Rheum. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3305 HGNC: 5234 AceView: HSPA1LandLSM2 Ensembl:ENSG00000204390 euGenes: HUgn3305
    ECgene: HSPA1L Kegg: 3305 H-InvDB: HSPA1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HSPA1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA1L Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1l/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HSPA1L gene:
    Search GeneIP for patents involving HSPA1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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