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Aliases for HSPA1L Gene

Aliases for HSPA1L Gene

  • Heat Shock Protein Family A (Hsp70) Member 1 Like 2 3 5
  • Heat Shock 70kDa Protein 1-Like 2 3
  • Heat Shock 70 KDa Protein 1-Hom 3 4
  • Heat Shock 70kD Protein-Like 1 2 3
  • Heat Shock 70 KDa Protein 1L 3 4
  • HSP70-HOM 3 4
  • Heat Shock 70 KDa Protein 1-Like 3
  • Heat Shock 10kDa Protein 1-Like 3
  • HSP70-1L 3
  • HSP70T 3
  • Hum70t 3

External Ids for HSPA1L Gene

Previous GeneCards Identifiers for HSPA1L Gene

  • GC06M031849
  • GC06M031548
  • GC06M031881
  • GC06M031885
  • GC06M031777
  • GC06M031563

Summaries for HSPA1L Gene

Entrez Gene Summary for HSPA1L Gene

  • This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1L Gene

HSPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like) is a Protein Coding gene. Diseases associated with HSPA1L include Pneumoconiosis. Among its related pathways are MAPK signaling pathway and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSPA1B.

UniProtKB/Swiss-Prot for HSPA1L Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).

Gene Wiki entry for HSPA1L Gene

Additional gene information for HSPA1L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1L Gene

Genomics for HSPA1L Gene

GeneHancer (GH) Regulatory Elements for HSPA1L Gene

Promoters and enhancers for HSPA1L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I031813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.6 -3.9 -3877 25.6 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 C6orf48 HSPA1B HSPA1A HSPA1L GC06P032039 ATF6B DDX39B LY6G5B LSM2 BAG6
GH06I031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.5 +84.5 84544 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 DDX39B LY6G5B ATF6B LSM2 CSNK2B SKIV2L GPANK1 BAG6
GH06I031557 Enhancer 1.2 Ensembl ENCODE 10 +262.4 262408 4.2 HDGF ATF1 SMAD1 IRF4 NCOA2 TCF12 E2F8 ZNF207 ZNF143 ATF7 LTA CSNK2B DDX39B LST1 NCR3 UQCRHP1 LTB AIF1 SNORD117 PSORS1C2
GH06I031385 Enhancer 0.2 FANTOM5 2.5 +436.8 436778 0.1 MICA-AS1 CCHCR1 PSORS1C2 HSPA1L MCCD1 GPANK1 BAG6 GC06P031577 GC06M031411
GH06I031811 Enhancer 0.2 Ensembl 0.4 +10.5 10498 1 HSPA1A LSM2 HSPA1L
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPA1L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA1L gene promoter:

Genomic Locations for HSPA1L Gene

Genomic Locations for HSPA1L Gene
chr6:31,809,619-31,821,999
(GRCh38/hg38)
Size:
12,381 bases
Orientation:
Minus strand
chr6:31,777,396-31,783,437
(GRCh37/hg19)

Genomic View for HSPA1L Gene

Genes around HSPA1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1L Gene

  • Protein details for HSPA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34931-HS71L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1-like
    Protein Accession:
    P34931
    Secondary Accessions:
    • A6NNB0
    • B0UXW8
    • O75634
    • Q2HXR3
    • Q8NE72
    • Q96QC9
    • Q9UQM1

    Protein attributes for HSPA1L Gene

    Size:
    641 amino acids
    Molecular mass:
    70375 Da
    Quaternary structure:
    • Interacts with PRKN.

    Three dimensional structures from OCA and Proteopedia for HSPA1L Gene

neXtProt entry for HSPA1L Gene

Post-translational modifications for HSPA1L Gene

No Post-translational modifications

Other Protein References for HSPA1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1L Gene

Domains & Families for HSPA1L Gene

Gene Families for HSPA1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSPA1L Gene

Suggested Antigen Peptide Sequences for HSPA1L Gene

Graphical View of Domain Structure for InterPro Entry

P34931

UniProtKB/Swiss-Prot:

HS71L_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1L: view

Function for HSPA1L Gene

Molecular function for HSPA1L Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1-like 2,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Positive regulator of PRKN translocation to damaged mitochondria (PubMed:24270810).
UniProtKB/Swiss-Prot Induction:
Not induced by heat shock.

Phenotypes From GWAS Catalog for HSPA1L Gene

Gene Ontology (GO) - Molecular Function for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17184779
GO:0005524 ATP binding IEA --
GO:0031072 heat shock protein binding IPI 17182002
GO:0031625 ubiquitin protein ligase binding IPI 24270810
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with HSPA1L: view
genes like me logo Genes that share phenotypes with HSPA1L: view

Animal Model Products

CRISPR Products

miRNA for HSPA1L Gene

miRTarBase miRNAs that target HSPA1L

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA1L Gene

Localization for HSPA1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1L gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA 21231916
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0044297 cell body IEA --
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA1L Gene

Pathways & Interactions for HSPA1L Gene

genes like me logo Genes that share pathways with HSPA1L: view

Gene Ontology (GO) - Biological Process for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein TAS 9685725
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0042026 protein refolding IDA 21231916
GO:1900034 regulation of cellular response to heat TAS --
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for SIGNOR curated interactions for HSPA1L Gene

Drugs & Compounds for HSPA1L Gene

(1) Drugs for HSPA1L Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 134
genes like me logo Genes that share compounds with HSPA1L: view

Transcripts for HSPA1L Gene

mRNA/cDNA for HSPA1L Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(199) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA1L Gene

Heat shock 70kDa protein 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1L Gene

No ASD Table

Relevant External Links for HSPA1L Gene

GeneLoc Exon Structure for
HSPA1L
ECgene alternative splicing isoforms for
HSPA1L

Expression for HSPA1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1L Gene

This gene is overexpressed in Testis (x19.5).

Protein differential expression in normal tissues from HIPED for HSPA1L Gene

This gene is overexpressed in Neutrophil (11.6), Saliva (10.9), Blymphocyte (6.2), and Nasal epithelium (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA1L Gene



NURSA nuclear receptor signaling pathways regulating expression of HSPA1L Gene:

HSPA1L

SOURCE GeneReport for Unigene cluster for HSPA1L Gene:

Hs.690634

mRNA Expression by UniProt/SwissProt for HSPA1L Gene:

P34931-HS71L_HUMAN
Tissue specificity: Expressed in spermatids.

Evidence on tissue expression from TISSUES for HSPA1L Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with HSPA1L: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA1L Gene

Orthologs for HSPA1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA1L 33 34
  • 99.48 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA1L 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA1L 33 34
  • 90.07 (n)
dog
(Canis familiaris)
Mammalia HSPA1L 33 34
  • 89.34 (n)
mouse
(Mus musculus)
Mammalia Hspa1l 33 16 34
  • 85.28 (n)
rat
(Rattus norvegicus)
Mammalia Hspa1l 33
  • 84.56 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 82 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii hsp70.3 34
  • 84 (a)
ManyToMany
hsc70 34
  • 82 (a)
ManyToMany
si:ch211-199o1.2 33
  • 75.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 35 34
  • 82 (a)
Hsc70-1 35 34
  • 79 (a)
Hsp70Ba 35 34
  • 76 (a)
Hsp70Bb 35 34
  • 76 (a)
Hsp70Bc 35 34
  • 76 (a)
Hsp70Aa 35 34
  • 75 (a)
Hsp70Ab 35 34
  • 75 (a)
Hsp70Bbb 34
  • 74 (a)
ManyToMany
Hsc70-2 35 34
  • 73 (a)
Hsp68 35 34
  • 71 (a)
Hsc70-3 35
  • 62 (a)
CG7182 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 35 34
  • 80 (a)
hsp-2 35
  • 73 (a)
F44E5.4 35
  • 67 (a)
F44E5.5 35
  • 67 (a)
hsp-70 35
  • 66 (a)
hsp-3 35
  • 61 (a)
hsp-4 35
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 34
  • 72 (a)
OneToMany
SSA1 33 36
  • 64.66 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR114W 33
  • 67.09 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04224g 33
  • 65.93 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Hsp70b 33
  • 64.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 34
  • 79 (a)
ManyToMany
CSA.971 34
  • 74 (a)
ManyToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssa2 33
  • 67.56 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09602 33
  • 66.51 (n)
Species where no ortholog for HSPA1L was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA1L Gene

ENSEMBL:
Gene Tree for HSPA1L (if available)
TreeFam:
Gene Tree for HSPA1L (if available)

Paralogs for HSPA1L Gene

Paralogs for HSPA1L Gene

(16) SIMAP similar genes for HSPA1L Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HSPA1L Gene

genes like me logo Genes that share paralogs with HSPA1L: view

Variants for HSPA1L Gene

Sequence variations from dbSNP and Humsavar for HSPA1L Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs139868987 association, Inflammatory bowel disease 1 31,811,173(-) G/A coding_sequence_variant, missense_variant
rs2227955 association, Inflammatory bowel disease 1 31,810,300(-) T/G coding_sequence_variant, missense_variant
rs34620296 association, Inflammatory bowel disease 1 31,811,171(-) C/T coding_sequence_variant, missense_variant
rs368138379 association, Inflammatory bowel disease 1 31,811,744(-) C/T coding_sequence_variant, missense_variant
rs750447828 association, Inflammatory bowel disease 1 31,811,456(-) TTA/ coding_sequence_variant, inframe_deletion

Structural Variations from Database of Genomic Variants (DGV) for HSPA1L Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv823502 CNV loss 20364138
nsv823503 CNV loss 20364138

Variation tolerance for HSPA1L Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA1L Gene

Human Gene Mutation Database (HGMD)
HSPA1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1L Gene

Disorders for HSPA1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA1L Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pneumoconiosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSPA1L

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSPA1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1L Gene

Publications for HSPA1L Gene

  1. Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. (PMID: 9685725) Ito Y … Fujimoto H (Journal of biochemistry 1998) 2 3 4 22 58
  2. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li JX … Niu WQ (Cell stress & chaperones 2009) 3 22 44 58
  3. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae CU … Serretti A (Neuropsychobiology 2009) 3 22 44 58
  4. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. (PMID: 19731315) Mir KA … Ramakrishna BS (The British journal of surgery 2009) 3 22 44 58
  5. Heat-shock protein-70 genes and response to antidepressants in major depression. (PMID: 17428599) Pae CU … Paik IH (Progress in neuro-psychopharmacology & biological psychiatry 2007) 3 22 44 58

Products for HSPA1L Gene

Sources for HSPA1L Gene

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