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Aliases for HSPA1L Gene

Aliases for HSPA1L Gene

  • Heat Shock Protein Family A (Hsp70) Member 1 Like 2 3 5
  • Heat Shock 70kDa Protein 1-Like 2 3
  • Heat Shock 70 KDa Protein 1-Hom 3 4
  • Heat Shock 70kD Protein-Like 1 2 3
  • Heat Shock 70 KDa Protein 1L 3 4
  • HSP70-HOM 3 4
  • Heat Shock 10kDa Protein 1-Like 3
  • HSP70-1L 3
  • HSP70T 3
  • Hum70t 3

External Ids for HSPA1L Gene

Previous GeneCards Identifiers for HSPA1L Gene

  • GC06M031849
  • GC06M031548
  • GC06M031881
  • GC06M031885
  • GC06M031777
  • GC06M031563

Summaries for HSPA1L Gene

Entrez Gene Summary for HSPA1L Gene

  • This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1L Gene

HSPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like) is a Protein Coding gene. Diseases associated with HSPA1L include paranoid schizophrenia. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA1L Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.

Gene Wiki entry for HSPA1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1L Gene

Genomics for HSPA1L Gene

Regulatory Elements for HSPA1L Gene

Genomic Location for HSPA1L Gene

Chromosome:
6
Start:
31,809,619 bp from pter
End:
31,821,999 bp from pter
Size:
12,381 bases
Orientation:
Minus strand

Genomic View for HSPA1L Gene

Genes around HSPA1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1L Gene

  • Protein details for HSPA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34931-HS71L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1-like
    Protein Accession:
    P34931
    Secondary Accessions:
    • A6NNB0
    • B0UXW8
    • O75634
    • Q2HXR3
    • Q8NE72
    • Q96QC9
    • Q9UQM1

    Protein attributes for HSPA1L Gene

    Size:
    641 amino acids
    Molecular mass:
    70375 Da
    Quaternary structure:
    • Interacts with PARK2.

    Three dimensional structures from OCA and Proteopedia for HSPA1L Gene

neXtProt entry for HSPA1L Gene

Proteomics data for HSPA1L Gene at MOPED

Post-translational modifications for HSPA1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA1L Gene

Domains & Families for HSPA1L Gene

Gene Families for HSPA1L Gene

Protein Domains for HSPA1L Gene

Suggested Antigen Peptide Sequences for HSPA1L Gene

Graphical View of Domain Structure for InterPro Entry

P34931

UniProtKB/Swiss-Prot:

HS71L_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1L: view

Function for HSPA1L Gene

Molecular function for HSPA1L Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1-like 2,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.
UniProtKB/Swiss-Prot Induction:
Not induced by heat shock.
genes like me logo Genes that share phenotypes with HSPA1L: view

Animal Model Products

miRNA for HSPA1L Gene

miRTarBase miRNAs that target HSPA1L

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA1L Gene

Localization for HSPA1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1L Gene COMPARTMENTS Subcellular localization image for HSPA1L gene
Compartment Confidence
cytosol 3

Gene Ontology (GO) - Cellular Components for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005829 cytosol IDA 21231916
GO:0008180 colocalizes_with COP9 signalosome IDA 18850735
GO:0072562 blood microparticle IDA 22516433
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA1L Gene

Pathways & Interactions for HSPA1L Gene

genes like me logo Genes that share pathways with HSPA1L: view

Gene Ontology (GO) - Biological Process for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0034605 cellular response to heat TAS --
genes like me logo Genes that share ontologies with HSPA1L: view

No data available for SIGNOR curated interactions for HSPA1L Gene

Drugs & Compounds for HSPA1L Gene

(1) Drugs for HSPA1L Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 118
genes like me logo Genes that share compounds with HSPA1L: view

Transcripts for HSPA1L Gene

Unigene Clusters for HSPA1L Gene

Heat shock 70kDa protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1L Gene

No ASD Table

Relevant External Links for HSPA1L Gene

GeneLoc Exon Structure for
HSPA1L
ECgene alternative splicing isoforms for
HSPA1L

Expression for HSPA1L Gene

mRNA expression in normal human tissues for HSPA1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1L Gene

This gene is overexpressed in Testis (x19.5).

Protein differential expression in normal tissues from HIPED for HSPA1L Gene

This gene is overexpressed in Neutrophil (11.6), Saliva (10.9), Blymphocyte (6.2), and Nasal epithelium (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1L Gene



SOURCE GeneReport for Unigene cluster for HSPA1L Gene Hs.690634

mRNA Expression by UniProt/SwissProt for HSPA1L Gene

P34931-HS71L_HUMAN
Tissue specificity: Expressed in spermatids.
genes like me logo Genes that share expression patterns with HSPA1L: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for HSPA1L Gene

Orthologs for HSPA1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA1L 35
  • 90.07 (n)
  • 96.1 (a)
HSPA1L 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA1L 35
  • 89.34 (n)
  • 96.1 (a)
HSPA1L 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa1l 35
  • 84.56 (n)
  • 94.54 (a)
mouse
(Mus musculus)
Mammalia Hspa1l 16
Hspa1l 36
  • 95 (a)
OneToOne
Hspa1l 35
  • 85.28 (n)
  • 94.7 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA1L 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA1L 36
  • 99 (a)
OneToOne
HSPA1L 35
  • 99.48 (n)
  • 99.38 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 82 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-199o1.2 35
  • 75.04 (n)
  • 86.66 (a)
hsp70.3 36
  • 84 (a)
ManyToMany
hsc70 36
  • 82 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7182 37
  • 27 (a)
Hsc70-1 37
  • 79 (a)
Hsc70-2 37
  • 73 (a)
Hsc70-3 37
  • 62 (a)
Hsc70-4 37
  • 82 (a)
Hsp68 37
  • 71 (a)
Hsp70Aa 37
  • 75 (a)
Hsp70Ab 37
  • 75 (a)
Hsp70Ba 37
  • 76 (a)
Hsp70Bb 37
  • 76 (a)
Hsp70Bc 37
  • 76 (a)
Hsc70-1 36
  • 78 (a)
ManyToMany
Hsc70-2 36
  • 72 (a)
ManyToMany
Hsc70-4 36
  • 80 (a)
ManyToMany
Hsp68 36
  • 72 (a)
ManyToMany
Hsp70Aa 36
  • 74 (a)
ManyToMany
Hsp70Ab 36
  • 74 (a)
ManyToMany
Hsp70Ba 36
  • 74 (a)
ManyToMany
Hsp70Bb 36
  • 74 (a)
ManyToMany
Hsp70Bbb 36
  • 74 (a)
ManyToMany
Hsp70Bc 36
  • 74 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 67 (a)
F44E5.5 37
  • 67 (a)
hsp-1 37
  • 80 (a)
hsp-2 37
  • 73 (a)
hsp-3 37
  • 61 (a)
hsp-4 37
  • 60 (a)
hsp-70 37
  • 66 (a)
hsp-1 36
  • 81 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR114W 35
  • 67.09 (n)
  • 73.89 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04224g 35
  • 65.93 (n)
  • 74.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA1 35
  • 64.66 (n)
  • 74.64 (a)
SSA2 36
  • 72 (a)
OneToMany
SSA1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons Hsp70b 35
  • 64.79 (n)
  • 73.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09602 35
  • 66.51 (n)
  • 72.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssa2 35
  • 67.56 (n)
  • 74.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 79 (a)
ManyToMany
CSA.971 36
  • 74 (a)
ManyToMany
Species with no ortholog for HSPA1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA1L Gene

ENSEMBL:
Gene Tree for HSPA1L (if available)
TreeFam:
Gene Tree for HSPA1L (if available)

Paralogs for HSPA1L Gene

Paralogs for HSPA1L Gene

(16) SIMAP similar genes for HSPA1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1L: view

Variants for HSPA1L Gene

Sequence variations from dbSNP and Humsavar for HSPA1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2227956 - 31,810,495(-) AGCCA(C/T)GGACA reference, missense
rs9469057 - 31,811,951(+) TATGG(C/G/T)GATTC reference, missense
rs34620296 - 31,811,171(-) GCACC(A/G)CCTGC reference, missense
rs34360259 - 31,811,092(-) CATTG(A/G)CTTCT reference, missense
rs482145 - 31,810,537(+) CAAAC(A/G)TCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HSPA1L Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
dgv6584n71 CNV Loss 21882294
nsv823502 CNV Loss 20364138
nsv823503 CNV Loss 20364138

Variation tolerance for HSPA1L Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.17; 87.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA1L Gene

HapMap Linkage Disequilibrium report
HSPA1L
Human Gene Mutation Database (HGMD)
HSPA1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1L Gene

Disorders for HSPA1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paranoid schizophrenia
  • chronic paranoid schizophrenia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPA1L

Genetic Association Database (GAD)
HSPA1L
Human Genome Epidemiology (HuGE) Navigator
HSPA1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA1L
genes like me logo Genes that share disorders with HSPA1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1L Gene

Publications for HSPA1L Gene

  1. Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. (PMID: 9685725) Ito Y. … Fujimoto H. (J. Biochem. 1998) 2 3 4 23 67
  2. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li J.X. … Niu W.Q. (Cell Stress Chaperones 2009) 3 23
  3. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae C.U. … Serretti A. (Neuropsychobiology 2009) 3 23
  4. Heat-shock protein 70 gene polymorphism is associated with the severity of diabetic foot ulcer and the outcome of surgical treatment. (PMID: 19731315) Mir K.A. … Ramakrishna B.S. (Br J Surg 2009) 3 23
  5. Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia. (PMID: 18299791) Kim J.J. … Jun T.Y. (Eur Arch Psychiatry Clin Neurosci 2008) 3 23

Products for HSPA1L Gene

Sources for HSPA1L Gene

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