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Aliases for HSPA1L Gene

Aliases for HSPA1L Gene

  • Heat Shock 70kDa Protein 1-Like 2 3
  • Heat Shock 70 KDa Protein 1-Hom 3 4
  • Heat Shock 70kD Protein-Like 1 2 3
  • Heat Shock 70 KDa Protein 1L 3 4
  • HSP70-HOM 3 4
  • Heat Shock 70 KDa Protein 1-Like 3
  • Heat Shock 10kDa Protein 1-Like 3
  • HSP70-1L 3
  • HSP70T 3
  • Hum70t 3

External Ids for HSPA1L Gene

Summaries for HSPA1L Gene

Entrez Gene Summary for HSPA1L Gene

  • This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1L Gene

HSPA1L (Heat Shock 70kDa Protein 1-Like) is a Protein Coding gene. Diseases associated with HSPA1L include pulmonary edema and legionellosis. Among its related pathways are MAPK signaling pathway and Endocytosis. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA1L Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.

Gene Wiki entry for HSPA1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1L Gene

Genomics for HSPA1L Gene

Genomic Location for HSPA1L Gene

Start:
31,809,619 bp from pter
End:
31,821,040 bp from pter
Size:
11,422 bases
Orientation:
Minus strand

Genomic View for HSPA1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HSPA1L Gene

Proteins for HSPA1L Gene

  • Protein details for HSPA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34931-HS71L_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1-like
    Protein Accession:
    P34931
    Secondary Accessions:
    • A6NNB0
    • B0UXW8
    • O75634
    • Q2HXR3
    • Q8NE72
    • Q96QC9
    • Q9UQM1

    Protein attributes for HSPA1L Gene

    Size:
    641 amino acids
    Molecular mass:
    70375 Da
    Quaternary structure:
    • Interacts with PARK2.

    Three dimensional structures from OCA and Proteopedia for HSPA1L Gene

neXtProt entry for HSPA1L Gene

Proteomics data for HSPA1L Gene at MOPED

Post-translational modifications for HSPA1L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys161, Lys363, Lys425, Lys453, Lys509, and Lys514

Other Protein References for HSPA1L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1L Gene

Domains for HSPA1L Gene

Gene Families for HSPA1L Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA1L Gene

UniProtKB/Swiss-Prot:

HS71L_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • P34931
genes like me logo Genes that share domains with HSPA1L: view

Function for HSPA1L Gene

Molecular function for HSPA1L Gene

GENATLAS Biochemistry: heat shock 70kDa protein A1-like 2,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.
UniProtKB/Swiss-Prot Induction: Not induced by heat shock.

Gene Ontology (GO) - Molecular Function for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17184779
GO:0005524 ATP binding IEA --
GO:0051082 unfolded protein binding IDA 21231916
genes like me logo Genes that share ontologies with HSPA1L: view

miRNA for HSPA1L Gene

miRTarBase miRNAs that target HSPA1L

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA1L Gene

Localization for HSPA1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1L Gene COMPARTMENTS Subcellular localization image for HSPA1L gene
Compartment Confidence
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002199 zona pellucida receptor complex IEA --
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol IDA 21231916
genes like me logo Genes that share ontologies with HSPA1L: view

Pathways for HSPA1L Gene

genes like me logo Genes that share pathways with HSPA1L: view

Gene Ontology (GO) - Biological Process for HSPA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006986 response to unfolded protein TAS 9685725
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0034605 cellular response to heat TAS --
GO:0042026 protein refolding IDA 21231916
genes like me logo Genes that share ontologies with HSPA1L: view

Compounds for HSPA1L Gene

(1) PharmGKB related drug/compound annotations for HSPA1L Gene

Drug/compound Annotation
carbamazepine CA
genes like me logo Genes that share compounds with HSPA1L: view

Transcripts for HSPA1L Gene

Unigene Clusters for HSPA1L Gene

Heat shock 70kDa protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1L Gene

No ASD Table

Relevant External Links for HSPA1L Gene

GeneLoc Exon Structure for
HSPA1L
ECgene alternative splicing isoforms for
HSPA1L

Expression for HSPA1L Gene

mRNA expression in normal human tissues for HSPA1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1L Gene

This gene is overexpressed in Testis (19.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1L Gene

SOURCE GeneReport for Unigene cluster for HSPA1L Gene Hs.690634

mRNA Expression by UniProt/SwissProt for HSPA1L Gene

P34931-HS71L_HUMAN
Tissue specificity: Expressed in spermatids.
genes like me logo Genes that share expressions with HSPA1L: view

Orthologs for HSPA1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA1L 36
  • 99.48 (n)
  • 99.38 (a)
HSPA1L 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA1L 36
  • 90.07 (n)
  • 96.1 (a)
HSPA1L 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA1L 36
  • 89.34 (n)
  • 96.1 (a)
HSPA1L 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa1l 36
  • 85.28 (n)
  • 94.7 (a)
Hspa1l 16
Hspa1l 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA1L 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa1l 36
  • 84.56 (n)
  • 94.54 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 82 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii hsc70 37
  • 82 (a)
ManyToMany
hsp70.3 37
  • 84 (a)
ManyToMany
si:ch211-199o1.2 36
  • 75.04 (n)
  • 86.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 37
  • 78 (a)
ManyToMany
Hsc70-2 37
  • 72 (a)
ManyToMany
Hsc70-4 37
  • 80 (a)
ManyToMany
Hsp68 37
  • 72 (a)
ManyToMany
Hsp70Aa 37
  • 74 (a)
ManyToMany
Hsp70Ab 37
  • 74 (a)
ManyToMany
Hsp70Ba 37
  • 74 (a)
ManyToMany
Hsp70Bb 37
  • 74 (a)
ManyToMany
Hsp70Bbb 37
  • 74 (a)
ManyToMany
Hsp70Bc 37
  • 74 (a)
ManyToMany
Hsc70-4 38
  • 82 (a)
Hsc70-3 38
  • 62 (a)
Hsp70Aa 38
  • 75 (a)
Hsc70-1 38
  • 79 (a)
Hsp70Bb 38
  • 76 (a)
Hsp70Bc 38
  • 76 (a)
Hsc70-2 38
  • 73 (a)
Hsp68 38
  • 71 (a)
Hsp70Ba 38
  • 76 (a)
CG7182 38
  • 27 (a)
Hsp70Ab 38
  • 75 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 37
  • 81 (a)
OneToMany
F44E5.4 38
  • 67 (a)
hsp-70 38
  • 66 (a)
F44E5.5 38
  • 67 (a)
hsp-3 38
  • 61 (a)
hsp-1 38
  • 80 (a)
hsp-4 38
  • 60 (a)
hsp-2 38
  • 73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR114W 36
  • 67.09 (n)
  • 73.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA1 36
  • 64.66 (n)
  • 74.64 (a)
SSA1 39
SSA2 37
  • 72 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04224g 36
  • 65.93 (n)
  • 74.53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons Hsp70b 36
  • 64.79 (n)
  • 73.95 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09602 36
  • 66.51 (n)
  • 72.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssa2 36
  • 67.56 (n)
  • 74.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 37
  • 79 (a)
ManyToMany
CSA.971 37
  • 74 (a)
ManyToMany
Species with no ortholog for HSPA1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSPA1L Gene

ENSEMBL:
Gene Tree for HSPA1L (if available)
TreeFam:
Gene Tree for HSPA1L (if available)

Paralogs for HSPA1L Gene

Paralogs for HSPA1L Gene

Selected SIMAP similar genes for HSPA1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1L: view

Variants for HSPA1L Gene

Sequence variations from dbSNP and Humsavar for HSPA1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs481825 -- 31,812,817(+) aacaa(A/C)cattt intron-variant
rs482145 - 31,810,537(+) CAAAC(A/G)TCACC reference, missense
rs540316 -- 31,809,422(+) ggtgg(C/G)gggcg downstream-variant-500B
rs540369 -- 31,809,436(+) gtagt(C/G)ccagc downstream-variant-500B
rs552412 -- 31,809,300(+) GTAAT(C/T)CCAGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSPA1L Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
dgv6584n71 CNV Loss 21882294
nsv823502 CNV Loss 20364138
nsv823503 CNV Loss 20364138

Relevant External Links for HSPA1L Gene

HapMap Linkage Disequilibrium report
HSPA1L
Human Gene Mutation Database (HGMD)
HSPA1L

Disorders for HSPA1L Gene

(3) Novoseek inferred disease relationships for HSPA1L Gene

Disease -log(P) Hits PubMed IDs
shock 55.4 6
necrosis 0 1
tumors 0 1

Relevant External Links for HSPA1L

Genetic Association Database (GAD)
HSPA1L
Human Genome Epidemiology (HuGE) Navigator
HSPA1L
genes like me logo Genes that share disorders with HSPA1L: view

No data available for UniProtKB/Swiss-Prot for HSPA1L Gene

Publications for HSPA1L Gene

  1. Genomic structure of the spermatid-specific HSP70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. (PMID: 9685725) Ito Y. … Fujimoto H. (J. Biochem. 1998) 2 3 4 23
  2. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. (PMID: 12544996) SchrAPder O. … Laun R.A. (Crit. Care Med. 2003) 3 23 49
  3. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PMID: 15963589) Pae C.U. … Kim J.J. (Neurosci. Res. 2005) 3 23 49
  4. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. (PMID: 16525348) Bowers D.J. … Lowry S.F. (Shock 2006) 3 23 49
  5. Heat-shock protein-70 genes and response to antidepressants in major depression. (PMID: 17428599) Pae C.U. … Paik I.H. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2007) 3 23 49

Products for HSPA1L Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSPA1L
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA1L
    • Block miRNA regulation of HSPA1L using miScript Target Protectors

    Sources for HSPA1L Gene

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