Aliases for HSPA1L Gene
External Ids for HSPA1L Gene
Previous GeneCards Identifiers for HSPA1L Gene
This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSPA1L Gene
HSPA1L (Heat Shock Protein Family A (Hsp70) Member 1 Like) is a Protein Coding gene. Diseases associated with HSPA1L include Pneumoconiosis and Anthracosis. Among its related pathways are Development_Glucocorticoid receptor signaling and HSF1-dependent transactivation. GO annotations related to this gene include unfolded protein binding. An important paralog of this gene is HSPA1B.
UniProtKB/Swiss-Prot for HSPA1L Gene
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). Positive regulator of PARK2 translocation to damaged mitochondria.