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HSPA1B Gene

protein-coding   GIFtS: 63
GCID: GC06P031853

Heat Shock 70kDa Protein 1B

(Previous name: heat shock 70kD protein 1B)
  See HSPA1B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 1B1 2     HSP70-1B2
Heat Shock 70kD Protein 1B1 2     HSP70-22
Heat Shock 70 KDa Protein 1/22 3     Heat Shock 70 KDa Protein 1A/1B2
HSP70-1/HSP70-22 3     HSPA13
HSP70.1/HSP70.22 3     HSX703

External Ids:    HGNC: 52331   Entrez Gene: 33042   Ensembl: ENSG000002043887   OMIM: 6030125   UniProtKB: P081073   

Export aliases for HSPA1B gene to outside databases

Previous GC identifers: GC06P031867 GC06P031849 GC06P031566 GC06P031899 GC06P031903 GC06P031797 GC06P031813 GC06P031824


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA1B Gene:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In
conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and
mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the
ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is
located in the major histocompatibility complex class III region, in a cluster with two closely related genes
which encode similar proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSPA1B Gene:
HSPA1B (heat shock 70kDa protein 1B) is a protein-coding gene. Diseases associated with HSPA1B include mulibrey nanism, and acute mountain sickness. GO annotations related to this gene include protein N-terminus binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
serves as a post-attachment receptor for the virus to facilitate entry into the cell




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA1B gene promoter:
         Max1   PPAR-alpha   CP2   STAT3   NF-kappaB   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA1B promoter sequence
   Search Chromatin IP Primers for HSPA1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HSPA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031853:  view genomic region     (about GC identifiers)

Start:
31,795,512 bp from pter      End:
31,798,031 bp from pter
Size:
2,520 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167244 3,110,276-3,112,789      Chr6+,NT_113891.2 3,305,094-3,307,616      Chr6+,NT_167248 3,089,163-3,091,686     
Chr6+,NT_167245 3,081,099-3,083,618     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1A/1B  
Size: 641 amino acids; 70052 Da
Subunit: Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing
untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction
occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts
with TRIM5 (via B30.2/SPRY domain). Interacts with METTL21A
Selected PDB 3D structures from and Proteopedia for HSPA1B (see all 16):
1HJO (3D)        1S3X (3D)        1XQS (3D)        2E88 (3D)        2E8A (3D)        2LMG (3D)    
Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0
Alternative splicing: 2 isoforms:  P08107-1   P08107-2   

Explore the universe of human proteins at neXtProt for HSPA1B: NX_P08107

Explore proteomics data for HSPA1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys3, Lys56, Lys71, Lys77, Lys88, Lys102, Lys108, Lys112, Lys126, Lys159,
                                 Lys246, Lys319, Lys328, Lys348, Lys361, Lys423, Lys451, Lys497, Lys500, Lys507 (see all 29)
  • Modification sites at PhosphoSitePlus

  • See HSPA1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005337.2  
    ENSEMBL proteins: 
     ENSP00000364801   ENSP00000442789  
    Reactome Protein details: P08107

    HSPA1B Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPA1B
    Cloud-Clone Corp. Proteins for HSPA1B

     
    Search eBioscience for Proteins for HSPA1B 

     
    antibodies-online proteins for HSPA1B (9 products) 

     
    antibodies-online peptides for HSPA1B

    HSPA1B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA1B
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    ThermoFisher Antibody for HSPA1B
    antibodies-online antibodies for HSPA1B (13 products) 

    HSPA1B Assay Products:

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    Cloud-Clone Corp. ELISAs for HSPA1B
    Cloud-Clone Corp. CLIAs for HSPA1B
    Search eBioscience for ELISAs for HSPA1B 
    antibodies-online kits for HSPA1B (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P08107

    ProtoNet protein and cluster: P08107

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP71_HUMAN, P08107
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
    serves as a post-attachment receptor for the virus to facilitate entry into the cell
    Induction: By heat shock

         Genatlas biochemistry entry for HSPA1B:
    heat shock 70kDa protein A1B,acting as a molecular chaperone

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0003725double-stranded RNA binding IDA--
    GO:0005515protein binding IPI12853476
    GO:0005524ATP binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI15603737
         
    Find genes that share ontologies with HSPA1B           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Hspa1b):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  renal/urinary system  reproductive system 

    Find genes that share phenotypes with HSPA1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSPA1B: Hspa1btm1Bwy Hspa1btm1Jss Hspa1a/Hspa1bHspa1a/tm1Dix Hspa1btm1Clib

       genOway: Develop your customized and physiologically relevant rodent model for HSPA1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA1B:
    hsa-mir-146b-5p (MIRT041615), hsa-mir-330-5p (MIRT038259), hsa-mir-331-3p (MIRT043302), hsa-mir-324-5p (MIRT043071), hsa-mir-30d-5p (MIRT047804), hsa-mir-326 (MIRT043634), hsa-mir-106b-5p (MIRT044280), hsa-mir-324-3p (MIRT042885), hsa-let-7b-5p (MIRT052128), hsa-mir-361-5p (MIRT044093), hsa-mir-16-5p (MIRT001457), hsa-mir-615-3p (MIRT039797), hsa-mir-125b-5p (MIRT045893), hsa-mir-149-5p (MIRT045604), hsa-mir-378a-5p (MIRT043990), hsa-mir-34a-5p (MIRT025314), hsa-mir-484 (MIRT041823), hsa-mir-22-3p (MIRT050463), hsa-mir-877-3p (MIRT036829), hsa-mir-339-5p (MIRT042805), hsa-mir-940 (MIRT036594), hsa-mir-335-5p (MIRT016862), hsa-mir-505-3p (MIRT040998), hsa-mir-296-3p (MIRT038371), hsa-mir-197-3p (MIRT048091), hsa-mir-18a-3p (MIRT040888), hsa-mir-92a-3p (MIRT049240), hsa-mir-193b-3p (MIRT041254), hsa-mir-10a-5p (MIRT047607), hsa-mir-652-3p (MIRT039566), hsa-mir-1226-3p (MIRT036414), hsa-mir-92b-3p (MIRT040685), hsa-mir-130b-5p (MIRT038331), hsa-mir-1296-5p (MIRT036144), hsa-mir-423-3p (MIRT042499), hsa-mir-10b-5p (MIRT047430), hsa-mir-328-3p (MIRT043824), hsa-mir-25-3p (MIRT050317), hsa-mir-221-3p (MIRT046877), hsa-mir-378a-3p (MIRT043909), hsa-mir-744-5p (MIRT037558), hsa-mir-183-5p (MIRT047088), hsa-mir-425-3p (MIRT042427)

    Block miRNA regulation of human, mouse, rat HSPA1B using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HSPA1B:
    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA1B 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSPA1B
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSPA1B

    Clone
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    OriGene clones in human, mouse for HSPA1B (see all 6)
    OriGene ORF clones in mouse, rat for HSPA1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA1B (NM_005346)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA1B

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSP71_HUMAN, P08107: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol4
    cytoskeleton1
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10205060
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion TAS16130169
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005829cytosol TAS--

    Find genes that share ontologies with HSPA1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA1B About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3TWEAK Pathway
    Apoptosis Modulation by HSP700.35
    Viral RNP Complexes in the Host Cell Nucleus0.00
    4Influenza Viral RNA Transcription and Replication
    Influenza Life Cycle0.82
    Influenza Infection0.80
    5CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62


    Find genes that share SuperPaths with HSPA1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSPA1B
        Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells
    Cellular Transformation by HTLV1

    Selected GeneGo (Thomson Reuters) Pathways for HSPA1B (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    5 BioSystems Pathways for HSPA1B
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway
    Apoptosis Modulation by HSP70
    Direct p53 effectors
    FOXM1 transcription factor network

    5 Reactome Pathways for HSPA1B
        Regulation of HSF1-mediated heat shock response
    AUF1 (hnRNP D0) destabilizes mRNA
    HSF1-dependent transactivation
    Viral RNP Complexes in the Host Cell Nucleus
    Attenuation phase


    Selected Kegg Pathways  (Kegg details for HSPA1B) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1B (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA1B (P081071, 2, 3 ENSP000003648014) via UniProtKB, MINT, STRING, and/or I2D (see all 600)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCAP378401, 2, 3EBI-629985,EBI-985879 MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-8211605 MINT-7556901 I2D: score=2 
    STUB1Q9UNE71, 2, 3EBI-629985,EBI-357085 MINT-7903424 I2D: score=4 
    HSP90AB1P082382, 3, ENSP000003258754MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000325875
    AIFM1O958312, 3MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 
    BAG1Q999332, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006402mRNA catabolic process IDA10205060
    GO:0006986response to unfolded protein IDA10859165
    GO:0008285negative regulation of cell proliferation IMP9553041
    GO:0010467gene expression TAS--

    Find genes that share ontologies with HSPA1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA1B (HSP71)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA1B gene: 
    NM_005346.4  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375650(uc003nxk.2) ENST00000545241
    miRNA
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    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidHSPA1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA1B
    Clone
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    OriGene clones in human, mouse for HSPA1B (see all 6)
    OriGene ORF clones in mouse, rat for HSPA1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA1B (NM_005346)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA1B
    Primer
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    OriGene qPCR primer pairs and template standards for HSPA1B
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA1B
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA1B
      QuantiFast Probe-based Assays in human, mouse, rat HSPA1B

    Selected AceView cDNA sequences (see all 326):

    BQ716106 CB216405 BX450712 AW627638 D54490 N71203 BE382975 BQ718673 
    BQ717293 BQ638197 BQ362820 AA381832 BM505106 BI712613 BX429885 AI815405 
    BQ638251 F09929 BX388726 AA386402 BU146273 D57316 BI715436 AI671261 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSPA1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGCGCCG
    HSPA1B Expression
    About this image


    HSPA1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    HSPA1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA1B Protein Expression

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Tissue specificity: HSPA1B is testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1B (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA1B gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa1b5
    Hspa1a1
    heat shock protein 1B5
    heat shock protein 1A1
    91.52(n)1
    95.32(a)1
      17 (18.50 cM)5
    1937401  NM_010479.21  NP_034609.21 
     349564365 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    84(a)
    many ↔ many
    LGf(897907-924982)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004854411 heat shock 70 kDa protein-like 78.36(n)
    88.36(a)
      100485441  XM_002937639.2  XP_002937685.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsc701 heat shock cognate 70 75.4(n)
    85.92(a)
      393586  NM_200614.1  NP_956908.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43
    Hsp70Bc1
    neurotransmitter secretion chaperone3
    Heat-shock-protein-70Bc1
    82(a)
    (best of 11)3
    74.71(n)1
    77.36(a)1
      88E43
    485831  NM_141952.21  NP_650209.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSA4(YER103W)4
    SSA41
    Heat shock protein that is highly induced upon stress; more4
    SSA41
    63.59(n)1
    75.74(a)1
      5(364589-366517)4
    8568401, 4  NP_011029.31  NP_011029.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G024901 AT5G02490 68.52(n)
    76.72(a)
      831856  NM_120327.4  NP_195869.1 
    barley
    (Hordeum vulgare)
    Liliopsida L32165.12   -- 75.65(n)    L32165.1 


    ENSEMBL Gene Tree for HSPA1B (if available)
    TreeFam Gene Tree for HSPA1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA1B gene
    HSPA1A1 2  HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA62  HSPA142  HSPA22  
    16 SIMAP similar genes for HSPA1B using alignment to 1 protein entry:     HSP71_HUMAN:
    HSP70-1    HSPA1A    HSPA1L    HSPA2    HSPA6    HSPA7
    LOC401308    HSPA8    HSPA5    HSPA9    HSPA14    HSPA13
    HS24/p52    HSPA4    HSPA4L    HSPH1

    Find genes that share paralogs with HSPA1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA1B (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429195571,2
    --31793527(+) GGCTA-/TTTTTT 1 -- us2k10--------
    rs1411938811,2
    C--31793612(+) TCAGAC/TGCCTA 1 -- us2k10--------
    rs344671491,2
    C,F,H--31793716(+) GAATCC/TGCAGG 1 -- us2k19Minor allele frequency- T:0.01NS NA 600
    rs346148361,2
    C,F--31793781(+) AACCCT/GGTCTC 1 -- us2k15Minor allele frequency- G:0.01NS 158
    rs354409171,2
    C--31793808(+) ATTAGC/ACCGGC 1 -- us2k15Minor allele frequency- A:0.01NS 158
    rs349797181,2
    C--31793832(+) CTGTAA/TTTCCA 1 -- us2k15Minor allele frequency- T:0.01NS 158
    rs413123171,2
    F--31793903(+) GCAGAG/AATCTC 1 -- us2k13Minor allele frequency- A:0.02NA 144
    rs1121320611,2
    --31793996(+) TCACGT/CCTGTA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1913176891,2
    --31794044(+) GAGGTC/TAGGAG 1 -- us2k10--------
    rs349642641,2
    C,F--31794086(+) CACGAG/AGTCAG 1 -- us2k15Minor allele frequency- A:0.02NS 180

    HapMap Linkage Disequilibrium report for HSPA1B (31795512 - 31798031 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HSPA1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421830CNV Deletion20811451
    esv2667397CNV Deletion23128226
    dgv6583n71CNV Loss21882294
    dgv6590n71CNV Loss21882294
    dgv6589n71CNV Loss21882294
    dgv6582n71CNV Loss21882294
    dgv6592n71CNV Loss21882294
    dgv6591n71CNV Gain+Loss21882294

    Human Gene Mutation Database (HGMD): HSPA1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA1B
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603012    OMIM disorders: --

    2 diseases for HSPA1B:    
    About MalaCards
    mulibrey nanism    acute mountain sickness


    Find genes that share disorders with HSPA1B           About GenesLikeMe

    8 Novoseek inferred disease relationships for HSPA1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 69.3 36 7901896 (2), 16819288 (2), 7927536 (1), 17110616 (1) (see all 25)
    necrosis 17.6 5 12691826 (1), 15714129 (1), 18580445 (1), 11678832 (1)
    atherosclerotic plaque 12.4 1 16953332 (1)
    lupus erythematosus systemic 12.4 2 11196683 (1), 8655362 (1)
    inflammation 0.608 2 11030172 (1), 19661373 (1)
    tumors 0 6 12691826 (1), 15714129 (1), 18580445 (1)
    melanoma 0 1 9918409 (1)
    cancer 0 10 17363574 (4), 15741319 (4), 19914824 (1)

    Genetic Association Database (GAD): HSPA1B
    Human Genome Epidemiology (HuGE) Navigator: HSPA1B (83 documents)

    Export disorders for HSPA1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA1B gene, integrated from 10 sources (see all 248):
    (articles sorted by number of sources associating them with HSPA1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)1, 2, 3, 9 Milner C.M. and Campbell R.D. (Immunogenetics 1990)
    2. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)1, 4, 9 Pae C.U....Kim J.J. (Neurosci. Res. 2005)
    3. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)1, 4, 9 Temple S.E....Waterer G.W. (Intensive Care Med 2004)
    4. Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure. (PubMed id 18759004)1, 4, 9 Gombos T....ProhA!szka Z. (amp 2008)
    5. Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity. (PubMed id 15223990)1, 4, 9 Zouari Bouassida K....Danguir J. (amp 2004)
    6. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. (PubMed id 18580445)1, 4, 9 Tukiainen E....Repo H. (Pancreas 2008)
    7. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PubMed id 19439993)1, 4, 9 Pae C.U....Serretti A. (Neuropsychobiology 2009)
    8. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PubMed id 18518860)1, 4, 9 Buraczynska M....Ksiazek A. (Clin. Sci. 2009)
    9. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. (PubMed id 16525348)1, 4, 9 Bowers D.J....Lowry S.F. (Shock 2006)
    10. Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis. (PubMed id 15714129)1, 4, 9 Balog A....MA!ndi Y. (Pancreas 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3304 HGNC: 5233 AceView: HSPA1AandHSPA1B Ensembl:ENSG00000204388 euGenes: HUgn3304
    ECgene: HSPA1B Kegg: 3304 H-InvDB: HSPA1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA1B gene:
    Search GeneIP for patents involving HSPA1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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