Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPA1B Gene

Aliases for HSPA1B Gene

  • Heat Shock 70kDa Protein 1B 2 3
  • Heat Shock 70 KDa Protein 1/2 3 4
  • Heat Shock 70kD Protein 1B 2 3
  • HSP70-1/HSP70-2 3 4
  • HSP70.1/HSP70.2 3 4
  • Heat Shock 70 KDa Protein 1A/1B 3
  • HSPA1A HSPA1B 4
  • HSP70-1B 3
  • HSP70-2 3
  • HSPA1 4
  • HSX70 4

External Ids for HSPA1B Gene

Summaries for HSPA1B Gene

Entrez Gene Summary for HSPA1B Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1B Gene

HSPA1B (Heat Shock 70kDa Protein 1B) is a Protein Coding gene. Diseases associated with HSPA1B include mulibrey nanism and acute mountain sickness. Among its related pathways are MAPK signaling pathway and Disease. GO annotations related to this gene include ubiquitin protein ligase binding and protein N-terminus binding. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA1B Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1B Gene

Genomics for HSPA1B Gene

Genomic Location for HSPA1B Gene

Start:
31,827,735 bp from pter
End:
31,830,255 bp from pter
Size:
2,521 bases
Orientation:
Plus strand

Genomic View for HSPA1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HSPA1B Gene

Proteins for HSPA1B Gene

  • Protein details for HSPA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08107-HSP71_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1A/1B
    Protein Accession:
    P08107
    Secondary Accessions:
    • B4E3B6
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1B Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089).

    Three dimensional structures from OCA and Proteopedia for HSPA1B Gene

    Alternative splice isoforms for HSPA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA1B Gene

Proteomics data for HSPA1B Gene at MOPED

Post-translational modifications for HSPA1B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys56, Lys71, Lys77, Lys88, Lys102, Lys108, Lys112, Lys126, Lys159, Lys246, Lys319, Lys328, Lys348, Lys361, Lys423, Lys451, Lys497, Lys500, Lys507, Lys512, Lys524, Lys526, Lys539, Lys550, Lys559, Lys561, Lys597, and Lys628

Other Protein References for HSPA1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1B Gene

Domains for HSPA1B Gene

Gene Families for HSPA1B Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA1B Gene

Suggested Antigen Peptide Sequences for HSPA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08107

UniProtKB/Swiss-Prot:

HSP71_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • P08107
genes like me logo Genes that share domains with HSPA1B: view

Function for HSPA1B Gene

Molecular function for HSPA1B Gene

GENATLAS Biochemistry: heat shock 70kDa protein A1B,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Induction: By heat shock

Gene Ontology (GO) - Molecular Function for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 12853476
GO:0005524 ATP binding IDA 23921388
genes like me logo Genes that share ontologies with HSPA1B: view
genes like me logo Genes that share phenotypes with HSPA1B: view

Animal Models for HSPA1B Gene

MGI Knock Outs for HSPA1B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSPA1B Gene

Localization for HSPA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1B Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1B Gene COMPARTMENTS Subcellular localization image for HSPA1B gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 4
cytoskeleton 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005634 nucleus IDA 10205060
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion TAS 16130169
genes like me logo Genes that share ontologies with HSPA1B: view

Pathways for HSPA1B Gene

genes like me logo Genes that share pathways with HSPA1B: view

Gene Ontology (GO) - Biological Process for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006200 obsolete ATP catabolic process --
GO:0006402 mRNA catabolic process IDA 10205060
GO:0006986 response to unfolded protein IDA 10859165
GO:0008285 negative regulation of cell proliferation IMP 9553041
genes like me logo Genes that share ontologies with HSPA1B: view

Transcripts for HSPA1B Gene

mRNA/cDNA for HSPA1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(326) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA1B Gene

Heat shock 70kDa protein 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1B Gene

No ASD Table

Relevant External Links for HSPA1B Gene

GeneLoc Exon Structure for
HSPA1B
ECgene alternative splicing isoforms for
HSPA1B

Expression for HSPA1B Gene

mRNA expression in normal human tissues for HSPA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1B Gene

SOURCE GeneReport for Unigene cluster for HSPA1B Gene Hs.719966

mRNA Expression by UniProt/SwissProt for HSPA1B Gene

P08107-HSP71_HUMAN
Tissue specificity: HSPA1B is testis-specific
genes like me logo Genes that share expressions with HSPA1B: view

Orthologs for HSPA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
HSPA1A 35
  • 99.53 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia HSPA1A 35
  • 94.64 (n)
  • 98.75 (a)
HSPA1A 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
ManyToMany
HSPA1 36
  • 98 (a)
ManyToMany
LOC102155697 35
  • 94.8 (n)
  • 98.91 (a)
mouse
(Mus musculus)
Mammalia Hspa1a 35
  • 91.52 (n)
  • 95.32 (a)
Hspa1a 36
  • 95 (a)
ManyToMany
Hspa1b 16
Hspa1b 36
  • 95 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1a 35
  • 92.3 (n)
  • 96.57 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 35
  • 78.36 (n)
  • 88.36 (a)
zebrafish
(Danio rerio)
Actinopterygii hsc70 35
  • 75.4 (n)
  • 85.92 (a)
hsp70.2 36
  • 85 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 36
  • 79 (a)
ManyToMany
Hsc70-4 36
  • 81 (a)
ManyToMany
Hsp70Bc 35
  • 74.71 (n)
  • 77.36 (a)
Hsc70-4 37
  • 82 (a)
Hsc70-3 37
  • 62 (a)
Hsp70Aa 37
  • 76 (a)
Hsc70-1 37
  • 78 (a)
Hsp70Bb 37
  • 77 (a)
Hsp70Bc 37
  • 77 (a)
Hsc70-2 37
  • 75 (a)
Hsp68 37
  • 73 (a)
Hsp70Ba 37
  • 77 (a)
CG7182 37
  • 27 (a)
Hsp70Ab 37
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36
  • 82 (a)
OneToMany
F44E5.4 37
  • 68 (a)
hsp-70 37
  • 66 (a)
F44E5.5 37
  • 68 (a)
hsp-3 37
  • 61 (a)
hsp-1 37
  • 83 (a)
hsp-4 37
  • 60 (a)
hsp-2 37
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 35
  • 70.57 (n)
  • 76.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 74 (a)
OneToMany
SSA4 35
  • 63.59 (n)
  • 75.74 (a)
SSA4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 35
  • 62.82 (n)
  • 75.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 35
  • 68.52 (n)
  • 76.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 80 (a)
ManyToMany
CSA.971 36
  • 75 (a)
ManyToMany
Species with no ortholog for HSPA1B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1B Gene

ENSEMBL:
Gene Tree for HSPA1B (if available)
TreeFam:
Gene Tree for HSPA1B (if available)

Paralogs for HSPA1B Gene

Paralogs for HSPA1B Gene

Selected SIMAP similar genes for HSPA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1B: view

Variants for HSPA1B Gene

Sequence variations from dbSNP and Humsavar for HSPA1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs483638 -- 31,829,446(+) GGCCA(A/G)CAAGA reference, missense
rs539689 -- 31,829,810(-) AAGCC(C/G)CCAGG reference, synonymous-codon
rs1061623 -- 31,830,125(+) CTGCC(A/C)CCTTC utr-variant-3-prime
rs2607017 -- 31,827,883(-) CGCGA(C/G)AAGAG utr-variant-5-prime
rs2607018 -- 31,827,874(-) AGCTC(A/G)GTCCT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPA1B Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
dgv6589n71 CNV Loss 21882294
dgv6590n71 CNV Loss 21882294
esv2421830 CNV Deletion 20811451
esv2667397 CNV Deletion 23128226
dgv6591n71 CNV Gain+Loss 21882294
dgv6592n71 CNV Loss 21882294

Relevant External Links for HSPA1B Gene

HapMap Linkage Disequilibrium report
HSPA1B
Human Gene Mutation Database (HGMD)
HSPA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1B Gene

Disorders for HSPA1B Gene

(8) Novoseek inferred disease relationships for HSPA1B Gene

Disease -log(P) Hits PubMed IDs
shock 69.3 27
necrosis 17.6 4
atherosclerotic plaque 12.4 1
lupus erythematosus systemic 12.4 2
inflammation 0.608 2

Relevant External Links for HSPA1B

Genetic Association Database (GAD)
HSPA1B
Human Genome Epidemiology (HuGE) Navigator
HSPA1B
genes like me logo Genes that share disorders with HSPA1B: view

No data available for UniProtKB/Swiss-Prot for HSPA1B Gene

Publications for HSPA1B Gene

  1. Structure and expression of the three MHC-linked HSP70 genes. (PMID: 1700760) Milner C.M. … Campbell R.D. (Immunogenetics 1990) 2 3 4 23
  2. Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis. (PMID: 11696222) Niino M. … Tashiro K. (Tissue Antigens 2001) 3 23 48
  3. Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (PMID: 11779758) Vargas-AlarcA^n G. … Burgos-Vargas R. (Ann. Rheum. Dis. 2002) 3 23 48
  4. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. (PMID: 12544996) SchrAPder O. … Laun R.A. (Crit. Care Med. 2003) 3 23 48
  5. Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma. (PMID: 12691826) Jalbout M. … Chouchane L. (Cancer Lett. 2003) 3 23 48

Products for HSPA1B Gene

Sources for HSPA1B Gene

Back to Top

Content