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Aliases for HSPA1B Gene

Aliases for HSPA1B Gene

  • Heat Shock Protein Family A (Hsp70) Member 1B 2 3 5
  • Heat Shock 70kDa Protein 1B 2 3
  • Heat Shock 70 KDa Protein 2 3 4
  • Heat Shock 70kD Protein 1B 2 3
  • HSP70-2 3 4
  • HSP70.2 3 4
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • Heat Shock 70 KDa Protein 1B 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HSP70-1B 3

External Ids for HSPA1B Gene

Previous GeneCards Identifiers for HSPA1B Gene

  • GC06P031867
  • GC06P031849
  • GC06P031566
  • GC06P031899
  • GC06P031903
  • GC06P031797
  • GC06P031813
  • GC06P031824
  • GC06P031853
  • GC06P031828
  • GC06P031830
  • GC06P031870

Summaries for HSPA1B Gene

Entrez Gene Summary for HSPA1B Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1B Gene

HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B) is a Protein Coding gene. Diseases associated with HSPA1B include Acute Mountain Sickness and Mulibrey Nanism. Among its related pathways are Development_Glucocorticoid receptor signaling and Immune System. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot for HSPA1B Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1B Gene

Genomics for HSPA1B Gene

Regulatory Elements for HSPA1B Gene

Enhancers for HSPA1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F031817 1.5 FANTOM5 ENCODE 8.2 -5.0 -4956 10.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 BAG6 ATF6B SKIV2L DDX39B MICA LSM2 STK19B LY6G5B VARS C4A
GH06F031567 1.8 FANTOM5 Ensembl ENCODE 1.4 -249.5 -249465 22.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 DDX39B TNF LY6G5B DHX16 ATF6B LSM2 MICA TCF19 C6orf47 PPT2
GH06F031733 1.7 FANTOM5 ENCODE 1.4 -90.3 -90281 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF263 SP3 LY6G5C MICA LSM2 EHMT2 LY6G5B DXO GTF2H4 VARS ABHD16A ATF6B
GH06F031556 1.7 FANTOM5 Ensembl ENCODE 1.2 -267.6 -267603 8.3 HDGF PKNOX1 ARNT WRNIP1 ZNF2 ZNF207 FOS KLF13 ZNF263 PAF1 TNF ATP6V1G2 MICB CSNK2B DDX39B LST1 NCR3 UQCRHP1 AIF1 LTB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA1B on UCSC Golden Path with GeneCards custom track

Promoters for HSPA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264469 1265 4801 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for HSPA1B Gene

Chromosome:
6
Start:
31,827,735 bp from pter
End:
31,830,255 bp from pter
Size:
2,521 bases
Orientation:
Plus strand

Genomic View for HSPA1B Gene

Genes around HSPA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1B Gene

  • Protein details for HSPA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV9-HS71B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1B
    Protein Accession:
    P0DMV9
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1B Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486).

    Three dimensional structures from OCA and Proteopedia for HSPA1B Gene

neXtProt entry for HSPA1B Gene

Post-translational modifications for HSPA1B Gene

No Post-translational modifications

Other Protein References for HSPA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1B Gene

Domains & Families for HSPA1B Gene

Gene Families for HSPA1B Gene

Protein Domains for HSPA1B Gene

Suggested Antigen Peptide Sequences for HSPA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DMV9

UniProtKB/Swiss-Prot:

HS71B_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1B: view

Function for HSPA1B Gene

Molecular function for HSPA1B Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1B,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IDA 12150907
GO:0005102 receptor binding IPI 24790089
GO:0005515 protein binding IPI 15603737
genes like me logo Genes that share ontologies with HSPA1B: view

Phenotypes for HSPA1B Gene

genes like me logo Genes that share phenotypes with HSPA1B: view

Animal Models for HSPA1B Gene

MGI Knock Outs for HSPA1B:

Animal Model Products

miRNA for HSPA1B Gene

miRTarBase miRNAs that target HSPA1B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA1B Gene

Localization for HSPA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1B Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1B gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 24790089
GO:0005814 centriole IDA 24061851
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with HSPA1B: view

Pathways & Interactions for HSPA1B Gene

genes like me logo Genes that share pathways with HSPA1B: view

Interacting Proteins for HSPA1B Gene

Gene Ontology (GO) - Biological Process for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IMP 25281747
GO:0010941 NOT regulation of cell death IMP 21231916
GO:0031396 regulation of protein ubiquitination IDA 16809764
GO:0031397 negative regulation of protein ubiquitination IDA 12150907
GO:0032757 positive regulation of interleukin-8 production IMP 24790089
genes like me logo Genes that share ontologies with HSPA1B: view

No data available for SIGNOR curated interactions for HSPA1B Gene

Drugs & Compounds for HSPA1B Gene

(1) Drugs for HSPA1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(1) ApexBio Compounds for HSPA1B Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA1B: view

Transcripts for HSPA1B Gene

mRNA/cDNA for HSPA1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(326) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA1B Gene

Heat shock 70kDa protein 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1B Gene

No ASD Table

Relevant External Links for HSPA1B Gene

GeneLoc Exon Structure for
HSPA1B
ECgene alternative splicing isoforms for
HSPA1B

Expression for HSPA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSPA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for HSPA1B Gene

This gene is overexpressed in Uterus (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA1B Gene



Protein tissue co-expression partners for HSPA1B Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA1B Gene:

HSPA1B

SOURCE GeneReport for Unigene cluster for HSPA1B Gene:

Hs.719966

mRNA Expression by UniProt/SwissProt for HSPA1B Gene:

P0DMV9-HS71B_HUMAN
Tissue specificity: HSPA1B is testis-specific.
genes like me logo Genes that share expression patterns with HSPA1B: view

Primer Products

Orthologs for HSPA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
HSPA1A 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
ManyToMany
HSPA1 35
  • 98 (a)
ManyToMany
LOC102155697 34
  • 94.8 (n)
mouse
(Mus musculus)
Mammalia Hspa1b 35
  • 95 (a)
ManyToMany
Hspa1a 34 16 35
  • 91.52 (n)
cow
(Bos Taurus)
Mammalia HSPA1A 35 34
  • 94.64 (n)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1a 34
  • 92.3 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 34
  • 78.36 (n)
zebrafish
(Danio rerio)
Actinopterygii hsp70.2 35
  • 85 (a)
ManyToMany
hsc70 34
  • 75.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 36 35
  • 82 (a)
Hsc70-1 36 35
  • 78 (a)
Hsp70Ba 36
  • 77 (a)
Hsp70Bb 36
  • 77 (a)
Hsp70Aa 36
  • 76 (a)
Hsp70Ab 36
  • 76 (a)
Hsc70-2 36
  • 75 (a)
Hsp70Bc 36 34
  • 74.71 (n)
Hsp68 36
  • 73 (a)
Hsc70-3 36
  • 62 (a)
CG7182 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36 35
  • 83 (a)
hsp-2 36
  • 75 (a)
F44E5.4 36
  • 68 (a)
F44E5.5 36
  • 68 (a)
hsp-70 36
  • 66 (a)
hsp-3 36
  • 61 (a)
hsp-4 36
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 35
  • 74 (a)
OneToMany
SSA4 34 37
  • 63.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 34
  • 70.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 34
  • 62.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 34
  • 68.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 35
  • 80 (a)
ManyToMany
CSA.971 35
  • 75 (a)
ManyToMany
Species where no ortholog for HSPA1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1B Gene

ENSEMBL:
Gene Tree for HSPA1B (if available)
TreeFam:
Gene Tree for HSPA1B (if available)

Paralogs for HSPA1B Gene

Paralogs for HSPA1B Gene

(16) SIMAP similar genes for HSPA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1B: view

Variants for HSPA1B Gene

Sequence variations from dbSNP and Humsavar for HSPA1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1061623 -- 31,830,125(+) CTGCC(A/C)CCTTC utr-variant-3-prime
rs111862534 -- 31,827,227(+) GAGCC(A/G)GTCCG upstream-variant-2KB
rs112132061 -- 31,826,219(+) TCACG(C/T)CTGTA upstream-variant-2KB
rs112626070 -- 31,829,389(+) CGACA(A/T)CGATG reference, missense
rs113094932 -- 31,828,172(+) GCTGA(C/T)TGGCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HSPA1B Gene

Variant ID Type Subtype PubMed ID
nsv969380 CNV duplication 23825009
nsv1126749 CNV deletion 24896259
nsv1112900 CNV deletion 24896259
nsv1073969 CNV deletion 25765185
esv3890822 CNV loss 25118596
esv3608569 CNV loss 21293372
esv3329350 CNV duplication 20981092
esv2667397 CNV deletion 23128226
esv2421830 CNV deletion 20811451
dgv10463n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10403n54 CNV loss 21841781

Variation tolerance for HSPA1B Gene

Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA1B Gene

Human Gene Mutation Database (HGMD)
HSPA1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1B Gene

Disorders for HSPA1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute mountain sickness
  • altitude anoxia
mulibrey nanism
  • muscle-liver-brain-eye nanism
paranoid schizophrenia
  • chronic paranoid schizophrenia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPA1B

Genetic Association Database (GAD)
HSPA1B
Human Genome Epidemiology (HuGE) Navigator
HSPA1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA1B
genes like me logo Genes that share disorders with HSPA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1B Gene

Publications for HSPA1B Gene

  1. Structure and expression of the three MHC-linked HSP70 genes. (PMID: 1700760) Milner C.M. … Campbell R.D. (Immunogenetics 1990) 2 3 4 22 64
  2. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PMID: 18518860) Buraczynska M. … Ksiazek A. (Clin. Sci. 2009) 3 22 46 64
  3. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae C.U. … Serretti A. (Neuropsychobiology 2009) 3 22 46 64
  4. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li J.X. … Niu W.Q. (Cell Stress Chaperones 2009) 3 22 46 64
  5. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. (PMID: 18580445) Tukiainen E. … Repo H. (Pancreas 2008) 3 22 46 64

Products for HSPA1B Gene

Sources for HSPA1B Gene

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