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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA1B Gene

protein-coding   GIFtS: 64
GCID: GC06P031813

heat shock 70kDa protein 1B

(Previous name: heat shock 70kD protein 1B )
 Explore 71 diseases affiliated with
HSPA1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSPA1B    

Aliases
for HSPA1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock 70kDa Protein 1B1 2     HSP70.1/HSP70.22 3
HSP70-21 2     HSP70-1B2
Heat Shock 70kD Protein 1B1 2     Heat Shock 70 KDa Protein 1A/1B2
Heat Shock 70 KDa Protein 1/22 3     HSPA13
HSP70-1/HSP70-22 3     

External Ids:    HGNC: 52331   Entrez Gene: 33042   Ensembl: ENSG000002043887   OMIM: 6030125   UniProtKB: P081073   

Export aliases for HSPA1B gene to outside databases

Previous GC identifers: GC06P031867 GC06P031849 GC06P031566 GC06P031899 GC06P031903 GC06P031797


Summaries
for HSPA1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSPA1B:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In
conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates
the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the
ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located
in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode
similar proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate
the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate
in all these processes through their ability to recognize nonnative conformations of other proteins. They bind
extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane
translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment
receptor for the virus to facilitate entry into the cell




Genomic Views
for HSPA1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA1B gene promoter:
         Max1   PPAR-alpha   CP2   STAT3   NF-kappaB   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPA1B promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HSPA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031813:  view genomic region     (about GC identifiers)

Start:
 31,795,512 bp from pter      End:
 31,798,031 bp from pter
Size:
 2,520 bases      Orientation:
 plus strand

4 alternative locations:
Chr6+,ALT_REF_LOCI_3 31,777,702-31,791,259      Chr6+,ALT_REF_LOCI_2 31,782,890-31,824,600      Chr6+,ALT_REF_LOCI_1 31,806,879-31,817,692     
Chr6+,ALT_REF_LOCI_6 31,785,766-31,823,870     

Proteins
for HSPA1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1A/1B  
Size: 641 amino acids; 70052 Da
Subunit: Component of the CatSper complex (By similarity). Identified in a mRNP granule complex, at least composed of
ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2,
ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and
untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the
absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts
with CHCHD3. Interacts with TRIM5 (via B30.2/SPRY domain)
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
6/14 PDB 3D structures from and Proteopedia for HSPA1B (see all 14):
1HJO (3D)        1S3X (3D)        1XQS (3D)        2E88 (3D)        2E8A (3D)        2LMG (3D)    
Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0
Alternative splicing: 2 isoforms:  P08107-1   P08107-2   

Explore the universe of human proteins at neXtProt for HSPA1B: NX_P08107

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08107

    • HSPA1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005337.2  
    ENSEMBL proteins: 
     ENSP00000364801   ENSP00000442789  
    Reactome Protein details: P08107
    Human Recombinant Protein Products: 
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    Novus Biologicals HSPA1B Protein
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    ProSpec Recombinant Protein for HSPA1B
    Uscn Proteins for HSPA1B

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17167422
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion TAS16130169
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005829cytosol TAS--


    HSPA1B for ontologies           About GeneDecksing



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    Abcam antibodies for HSPA1B 
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    Assay Products for HSPA1B: 
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    Uscn ELISAs and CLIAs for HSPA1B

    Protein Domains /
    Families
    for HSPA1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSPA1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P08107

    ProtoNet protein and cluster: P08107

    1 Blocks protein family: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Similarity: Belongs to the heat shock protein 70 family


    Function
    for HSPA1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate
    the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate
    in all these processes through their ability to recognize nonnative conformations of other proteins. They bind
    extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane
    translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment
    receptor for the virus to facilitate entry into the cell
    Induction: By heat shock

         Genatlas biochemistry entry for HSPA1B:
    heat shock 70kDa protein A1B,acting as a molecular chaperone

    miRNA
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    hsa-miR-34a hsa-miR-34c-5p hsa-miR-449b hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: HSPA1B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA1B 

    Cell Line
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    Search LifeMap BioReagents cell lines for HSPA1B

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1B

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI15603737
    GO:0005524ATP binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI15603737
    GO:0044183protein binding involved in protein folding IDA15603737


    HSPA1B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HSPA1B: Hspa1btm1Bwy Hspa1btm1Jss Hspa1a/Hspa1bHspa1a/tm1Dix Hspa1btm1Clib
         9 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hspa1b):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  renal/urinary system  reproductive system 

    HSPA1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HSPA1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    		Development_Glucocorticoid receptor signaling0.27
    		CFTR folding and maturation (norm and CF)0.37
    		Development Glucocorticoid receptor signaling0.27
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    3Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    4Proteolysis Putative ubiquitin pathway
    		Proteolysis Putative ubiquitin pathway1.00
    		Proteolysis_Putative ubiquitin pathway0.97
    5MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HSPA1B
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSPA1B
        Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells
    Cellular Transformation by HTLV1

    5/6 GeneGo (Thomson Reuters) Pathways for HSPA1B (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    5 BioSystems Pathways for HSPA1B 
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway
    Apoptosis Modulation by HSP70
    Direct p53 effectors
    FOXM1 transcription factor network

    5/6        Reactome Pathways for HSPA1B (see all 6)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Ubiquitination of AUF1 (hnRNP D0)
    Destabilization of mRNA by AUF1 (hnRNP D0)
    Metabolism of RNA
    Metabolism of mRNA


    5/8         Kegg Pathways  (Kegg details for HSPA1B) (see all 8):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA1B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/552 Interacting proteins for HSPA1B (P081071, 2, 3 ENSP000003648014) via UniProtKB, MINT, STRING, and/or I2D (see all 552)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCAP378402, 3MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-7556901 MINT-8211605 I2D: score=2 
    STUB1Q9UNE71, 2, 3EBI-4404728,EBI-357085 MINT-7903424 I2D: score=4 
    AIFM1O958312, 3MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 
    BAG1Q999332, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    HSP90AB1P082382, 3MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006402mRNA catabolic process IDA10205060
    GO:0006986response to unfolded protein IDA10859165
    GO:0008285negative regulation of cell proliferation IMP9553041
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--


    HSPA1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSPA1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HSPA1B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA1B
    Search CenterWatch for drugs/clinical trials and news about HSPA1B / HSP71 

    Transcripts
    for HSPA1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSPA1B gene: 
    NM_005346.4  

    Unigene Cluster for HSPA1B:

    Heat shock 70kDa protein 1B
    Hs.719966  [show with all ESTs]
    Unigene Representative Sequence: NM_005346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375650(uc003nxk.2) ENST00000545241

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: HSPA1B 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK295398.1 AK303967.1 AL360193.1 BC001876.1 BC057397.1 BC063507.1 

    24/35 DOTS entries (see all 35):

    DT.309093  DT.100855495  DT.121331306  DT.100695127  DT.91787162  DT.100847810  DT.121331366  DT.100695123 
    DT.100695139  DT.100868791  DT.75141405  DT.100695138  DT.97794033  DT.100057333  DT.121331348  DT.121331533 
    DT.100847514  DT.102841819  DT.95213511  DT.100769435  DT.121331459  DT.121331463  DT.121331479  DT.97862661 

    24/326 AceView cDNA sequences (see all 326):

    AA386402 BQ717293 AW387720 AA380132 F09929 AK096017 BQ638251 BI712613 
    BI715436 BX450712 AA341804 BM564625 D54490 AI671261 BF445743 BF340013 
    BX337156 BQ718828 CD514945 AI815405 CA776954 AW627638 F02338 BM790717 

    GeneLoc Exon Structure


    Expression
    for HSPA1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAGCGCCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HSPA1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    AdiposeInterscapular Brown Adipose DepotAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HSPA1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA1B

    SOURCE GeneReport for Unigene cluster: Hs.719966

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Tissue specificity: HSPA1B is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA1B (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for HSPA1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA1B gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii hsp701 heat shock cognate 70-kd protein 79.2(n)
    86.56(a)    		   30671  NM_131397.2  NP_571472.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hsc70-43
    Hsp70Bc1    		 neurotransmitter secretion chaperone3
    Heat-shock-protein-70Bc1    		 82(a)
    (best of 11)3
    73.71(n)1
    76.5(a)1    		   88E43
    485831  NM_141952.21  NP_650209.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)    		   IV(17279119-17281340)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G094401 protein heat shock protein 70-3 68.08(n)
    76.42(a)    		   820102  NM_001202918.1  NP_001189847.1 
    barley
    (Hordeum vulgare)    		 Liliopsida L32165.12   -- 75.65(n)    L32165.1 


    ENSEMBL Gene Tree for HSPA1B (if available)
    TreeFam Gene Tree for HSPA1B (if available) 

    Paralogs
    for HSPA1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA1B gene
    HSPA1A1 2  HSPA82  HSPA52  HSPA1L2  HSPA62  HSPA142  HSPA132  
    16 SIMAP similar genes for HSPA1B using alignment to 2 protein entries:     HSP71_HUMAN (see all proteins):
    HSP70-1    HSPA2    HSPA6    HSPA1A    LOC401308    HSPA7
    HSPA1L    HSPA8    HSPA5    HSPA9    HSPA14    HSPA13
    HS24/p52    HSPA4    HSPA4L    HSPH1

    HSPA1B for paralogs           About GeneDecksing



    Genomic Variants
    for HSPA1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 NCBI SNPs in HSPA1B are shown (see all 104)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1429195571,2
    		--31793527(+) GGCTA-/TTTTTT 1 -- us2k10--------
    rs1411938811,2
    		--31793612(+) TCAGAC/TGCCTA 1 -- us2k10--------
    rs344671491,2
    		C,F,H,--31793716(+) GAATCC/TGCAGG 1 -- us2k19Minor allele frequency- T:0.01NS NA 600
    rs346148361,2
    		C,F,--31793781(+) AACCCT/GGTCTC 1 -- us2k15Minor allele frequency- G:0.01NS 158
    rs354409171,2
    		C,--31793808(+) ATTAGC/ACCGGC 1 -- us2k15Minor allele frequency- A:0.01NS 158
    rs349797181,2
    		C,--31793832(+) CTGTAA/TTTCCA 1 -- us2k15Minor allele frequency- T:0.01NS 158
    rs413123171,2
    		F--31793903(+) GCAGAG/AATCTC 1 -- us2k13Minor allele frequency- A:0.02NA 144
    rs1121320611,2
    		--31793996(+) TCACGT/CCTGTA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1913176891,2
    		--31794044(+) GAGGTC/TAGGAG 1 -- us2k10--------
    rs349642641,2
    		C,F,--31794086(+) CACGAG/AGTCAG 1 -- us2k15Minor allele frequency- A:0.02NS 180

    HapMap Linkage Disequilibrium report for HSPA1B (31795512 - 31798031 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSPA1B: --
    Human Gene Mutation Database (HGMD): HSPA1B

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    Disorders / Diseases
    for HSPA1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSPA1B for disorders           About GeneDecksing

    OMIM gene information: 603012    OMIM disorders: --

    20/71 diseases for HSPA1B (see all 71):    About MalaCards
    acute mountain sickness    non-small cell lung carcinoma    clostridium difficile    diabetic foot ulcers
    chronic obstructive pulmonary disease    lupus erythematosus    ankylosing spondylitis    systemic lupus erythematosus
    reactive arthritis    male infertility    hearing loss    duodenal ulcer
    acute lymphoblastic leukemia    dilated cardiomyopathy    lymphoblastic leukemia    pulmonary edema
    allergic asthma    ulcerative colitis    spondylitis    pneumoconiosis

    8 Novoseek disease relationships for HSPA1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 69.3 36 7901896 (2), 16819288 (2), 7927536 (1), 17110616 (1) (see all 25)
    necrosis 17.6 5 12691826 (1), 15714129 (1), 18580445 (1), 11678832 (1)
    atherosclerotic plaque 12.4 1 16953332 (1)
    lupus erythematosus systemic 12.4 2 11196683 (1), 8655362 (1)
    inflammation 0.608 2 11030172 (1), 19661373 (1)
    tumors 0 6 12691826 (1), 15714129 (1), 18580445 (1)
    melanoma 0 1 9918409 (1)
    cancer 0 10 17363574 (4), 15741319 (4), 19914824 (1)

    Genetic Association Database (GAD): HSPA1B
    Human Genome Epidemiology (HuGE) Navigator: HSPA1B (83 documents)

    Export disorders for HSPA1B gene to outside databases

    Publications
    for HSPA1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA1B gene, integrated from 9 sources (see all 213):
    (articles sorted by number of sources associating them with HSPA1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)1, 2, 3, 9 Milner C.M. and Campbell R.D. (1990)
    2. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)1, 4, 9 Pae C.U....Kim J.J. (2005)
    3. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)1, 4, 9 Temple S.E....Waterer G.W. (2004)
    4. Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity. (PubMed id 15223990)1, 4, 9 Zouari Bouassida K....Danguir J. (2004)
    5. Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis. (PubMed id 15714129)1, 4, 9 Balog A....Mandi Y. (2005)
    6. Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease. (PubMed id 16165702)1, 4, 9 Klausz G....Mandi Y. (2005)
    7. Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma. (PubMed id 12691826)1, 4, 9 Jalbout M....Chouchane L. (2003)
    8. Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury. (PubMed id 12544996)1, 4, 9 Schroder O....Laun R.A. (2003)
    9. Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (PubMed id 11779758)1, 4, 9 Vargas-Alarcon G....Burgos-Vargas R. (2002)
    10. Heat shock protein 70 gene polymorphism in Japanese patients with multiple sclerosis. (PubMed id 11696222)1, 4, 9 Niino M....Tashiro K. (2001)

    External Searches for HSPA1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSPA1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3304 HGNC: 5233 AceView: HSPA1AandHSPA1B Ensembl:ENSG00000204388 euGenes: HUgn3304
    ECgene: HSPA1B Kegg: 3304 H-InvDB: HSPA1B

    Other Databases showing HSPA1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSPA1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1a/

    Intellectual Property
    for HSPA1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSPA1B gene:
    Search GeneIP for patents involving HSPA1B

    GeneCards and IP:
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