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Aliases for HSPA1B Gene

Aliases for HSPA1B Gene

  • Heat Shock Protein Family A (Hsp70) Member 1B 2 3 5
  • Heat Shock 70kDa Protein 1B 2 3
  • Heat Shock 70 KDa Protein 2 3 4
  • Heat Shock 70kD Protein 1B 2 3
  • HSP70-2 3 4
  • HSP70.2 3 4
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • Heat Shock 70 KDa Protein 1B 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HSP70-1B 3
  • HSP72 4

External Ids for HSPA1B Gene

Previous GeneCards Identifiers for HSPA1B Gene

  • GC06P031867
  • GC06P031849
  • GC06P031566
  • GC06P031899
  • GC06P031903
  • GC06P031797
  • GC06P031813
  • GC06P031824
  • GC06P031853
  • GC06P031828
  • GC06P031830
  • GC06P031870
  • GC06P031872

Summaries for HSPA1B Gene

Entrez Gene Summary for HSPA1B Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1B Gene

HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B) is a Protein Coding gene. Diseases associated with HSPA1B include Mulibrey Nanism and Acute Mountain Sickness. Among its related pathways are PEDF Induced Signaling and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot for HSPA1B Gene

  • Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

  • (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1B Gene

Genomics for HSPA1B Gene

Regulatory Elements for HSPA1B Gene

Enhancers for HSPA1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031817 1.8 FANTOM5 ENCODE dbSUPER 8.2 -5.0 -4956 10.7 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ATF6B SKIV2L LSM2 DDX39B VARS LY6G5B BAG6 STK19B C4A CSNK2B
GH06G031567 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.4 -249.3 -249317 22.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 DDX39B TNF LY6G5B LSM2 DHX16 ATF6B TCF19 PPP1R10 VARS CSNK2B
GH06G031733 1.9 FANTOM5 ENCODE dbSUPER 1.4 -90.3 -90281 8.5 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 LY6G5C LSM2 LY6G5B VARS ABHD16A MICA EHMT2 PRRC2A C4A CLIC1
GH06G031562 0.9 FANTOM5 1.2 -265.5 -265496 0.4 TBL1XR1 DNMT3B ZNF48 ZNF2 RELB ETV6 IKZF2 CREM EGR2 PAF1 TNF ATP6V1G2 STK19 HLA-B LST1 HSPA1B LTA LOC100287329
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA1B on UCSC Golden Path with GeneCards custom track

Promoters for HSPA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320260 1165 4201 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for HSPA1B Gene

Chromosome:
6
Start:
31,827,735 bp from pter
End:
31,830,255 bp from pter
Size:
2,521 bases
Orientation:
Plus strand

Genomic View for HSPA1B Gene

Genes around HSPA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1B Gene

  • Protein details for HSPA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV9-HS71B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1B
    Protein Accession:
    P0DMV9
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1B Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486). Interacts with NAA10, HSP40, HSP90 and HDAC4. The acetylated form and the non-acetylated form interact with HOPX and STUB1 respectively (PubMed:27708256). Interacts with NEDD1 (PubMed:27137183). Interacts (via NBD) with BAG1, BAG2, BAG3 and HSPH1/HSP105 (PubMed:24318877). Interacts with SMAD3 (PubMed:24613385).

    Three dimensional structures from OCA and Proteopedia for HSPA1B Gene

neXtProt entry for HSPA1B Gene

Post-translational modifications for HSPA1B Gene

  • In response to cellular stress, acetylated at Lys-77 by NA110 and then gradually deacetylated by HDAC4 at later stages. Acetylation enhances its chaperone activity and also determines whether it will function as a chaperone for protein refolding or degradation by controlling its binding to co-chaperones HOPX and STUB1. The acetylated form and the non-acetylated form bind to HOPX and STUB1 respectively. Acetylation also protects cells against various types of cellular stress.

Other Protein References for HSPA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1B Gene

Domains & Families for HSPA1B Gene

Gene Families for HSPA1B Gene

Protein Domains for HSPA1B Gene

Suggested Antigen Peptide Sequences for HSPA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DMV9

UniProtKB/Swiss-Prot:

HS71B_HUMAN :
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
  • Belongs to the heat shock protein 70 family.
Domain:
  • The N-terminal nucleotide binding domain (NBD) (also known as the ATPase domain) is responsible for binding and hydrolyzing ATP. The C-terminal substrate-binding domain (SBD) (also known as peptide-binding domain) binds to the client/substrate proteins. The two domains are allosterically coupled so that, when ATP is bound to the NBD, the SBD binds relatively weakly to clients. When ADP is bound in the NBD, a conformational change enhances the affinity of the SBD for client proteins.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1B: view

Function for HSPA1B Gene

Molecular function for HSPA1B Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1B,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0001618 virus receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IDA 12150907
GO:0003723 RNA binding IDA 22658674
GO:0005102 receptor binding IPI 24790089
genes like me logo Genes that share ontologies with HSPA1B: view

Phenotypes for HSPA1B Gene

genes like me logo Genes that share phenotypes with HSPA1B: view

Animal Models for HSPA1B Gene

MGI Knock Outs for HSPA1B:

Animal Model Products

CRISPR Products

miRNA for HSPA1B Gene

miRTarBase miRNAs that target HSPA1B

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA1B Gene

Localization for HSPA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1B Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA1B gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 10205060
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS,IEA 16130169
genes like me logo Genes that share ontologies with HSPA1B: view

Pathways & Interactions for HSPA1B Gene

genes like me logo Genes that share pathways with HSPA1B: view

Interacting Proteins for HSPA1B Gene

Gene Ontology (GO) - Biological Process for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process IDA 10205060
GO:0008285 negative regulation of cell proliferation IMP 9553041
GO:0010628 positive regulation of gene expression IMP 25281747
GO:0010941 NOT regulation of cell death IMP 21231916
GO:0030308 negative regulation of cell growth IMP 9553041
genes like me logo Genes that share ontologies with HSPA1B: view

No data available for SIGNOR curated interactions for HSPA1B Gene

Drugs & Compounds for HSPA1B Gene

(1) Drugs for HSPA1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(1) ApexBio Compounds for HSPA1B Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA1B: view

Transcripts for HSPA1B Gene

mRNA/cDNA for HSPA1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(326) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA1B Gene

Heat shock 70kDa protein 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1B Gene

No ASD Table

Relevant External Links for HSPA1B Gene

GeneLoc Exon Structure for
HSPA1B
ECgene alternative splicing isoforms for
HSPA1B

Expression for HSPA1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for HSPA1B Gene

This gene is overexpressed in Uterus (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA1B Gene



Protein tissue co-expression partners for HSPA1B Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA1B Gene:

HSPA1B

SOURCE GeneReport for Unigene cluster for HSPA1B Gene:

Hs.719966

mRNA Expression by UniProt/SwissProt for HSPA1B Gene:

P0DMV9-HS71B_HUMAN
Tissue specificity: HSPA1B is testis-specific.

Evidence on tissue expression from TISSUES for HSPA1B Gene

  • Blood(2.4)
  • Muscle(2.3)
  • Heart(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with HSPA1B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA1B Gene

Orthologs for HSPA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToMany
HSPA1A 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
ManyToMany
HSPA1 35
  • 98 (a)
ManyToMany
LOC102155697 34
  • 94.8 (n)
mouse
(Mus musculus)
Mammalia Hspa1b 35
  • 95 (a)
ManyToMany
Hspa1a 34 16 35
  • 91.52 (n)
cow
(Bos Taurus)
Mammalia HSPA1A 34 35
  • 94.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1b 34
  • 92.3 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 34
  • 78.36 (n)
zebrafish
(Danio rerio)
Actinopterygii hsp70.2 35
  • 85 (a)
ManyToMany
hsc70 34
  • 75.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-4 36 35
  • 82 (a)
Hsc70-1 36 35
  • 78 (a)
Hsp70Ba 36
  • 77 (a)
Hsp70Bb 36
  • 77 (a)
Hsp70Aa 36
  • 76 (a)
Hsp70Ab 36
  • 76 (a)
Hsc70-2 36
  • 75 (a)
Hsp70Bc 36 34
  • 74.71 (n)
Hsp68 36
  • 73 (a)
Hsc70-3 36
  • 62 (a)
CG7182 36
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 36 35
  • 83 (a)
hsp-2 36
  • 75 (a)
F44E5.4 36
  • 68 (a)
F44E5.5 36
  • 68 (a)
hsp-70 36
  • 66 (a)
hsp-3 36
  • 61 (a)
hsp-4 36
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 35 37
  • 74 (a)
OneToMany
SSA4 34
  • 63.59 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 34
  • 70.57 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 34
  • 62.82 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 34
  • 68.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 35
  • 80 (a)
ManyToMany
CSA.971 35
  • 75 (a)
ManyToMany
Species where no ortholog for HSPA1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1B Gene

ENSEMBL:
Gene Tree for HSPA1B (if available)
TreeFam:
Gene Tree for HSPA1B (if available)

Paralogs for HSPA1B Gene

Paralogs for HSPA1B Gene

(16) SIMAP similar genes for HSPA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1B: view

Variants for HSPA1B Gene

Sequence variations from dbSNP and Humsavar for HSPA1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000261968 -- 31,830,136(+) TGTAC(G/T)AGTTT utr-variant-3-prime
rs1000695337 -- 31,827,760(+) AGCTG(C/T)TGCGA utr-variant-5-prime
rs1000762955 -- 31,830,235(+) TATGA(A/T)AAATA utr-variant-3-prime
rs1001260474 -- 31,829,224(+) GCAGA(C/T)GCAGA reference, missense
rs1002874434 -- 31,827,603(+) AGGCT(-/G)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPA1B Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10461n54 CNV loss 21841781
dgv10462n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
esv2421830 CNV deletion 20811451
esv2667397 CNV deletion 23128226
esv3329350 CNV duplication 20981092
esv3608569 CNV loss 21293372
esv3890822 CNV loss 25118596
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv969380 CNV duplication 23825009

Variation tolerance for HSPA1B Gene

Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA1B Gene

Human Gene Mutation Database (HGMD)
HSPA1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1B Gene

Disorders for HSPA1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSPA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mulibrey nanism
  • muscle-liver-brain-eye nanism
acute mountain sickness
  • altitude anoxia
paranoid schizophrenia
  • chronic paranoid schizophrenia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPA1B

Genetic Association Database (GAD)
HSPA1B
Human Genome Epidemiology (HuGE) Navigator
HSPA1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA1B
genes like me logo Genes that share disorders with HSPA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1B Gene

Publications for HSPA1B Gene

  1. Structure and expression of the three MHC-linked HSP70 genes. (PMID: 1700760) Milner C.M. … Campbell R.D. (Immunogenetics 1990) 2 3 4 22 64
  2. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PMID: 18518860) Buraczynska M. … Ksiazek A. (Clin. Sci. 2009) 3 22 46 64
  3. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li J.X. … Niu W.Q. (Cell Stress Chaperones 2009) 3 22 46 64
  4. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae C.U. … Serretti A. (Neuropsychobiology 2009) 3 22 46 64
  5. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. (PMID: 18580445) Tukiainen E. … Repo H. (Pancreas 2008) 3 22 46 64

Products for HSPA1B Gene

Sources for HSPA1B Gene

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