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Aliases for HSPA1B Gene

Aliases for HSPA1B Gene

  • Heat Shock Protein Family A (Hsp70) Member 1B 2 3 5
  • Heat Shock 70kDa Protein 1B 2 3
  • Heat Shock 70 KDa Protein 2 3 4
  • Heat Shock 70kD Protein 1B 2 3
  • HSP70-2 3 4
  • HSP70.2 3 4
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HSP70-1B 3

External Ids for HSPA1B Gene

Previous GeneCards Identifiers for HSPA1B Gene

  • GC06P031867
  • GC06P031849
  • GC06P031566
  • GC06P031899
  • GC06P031903
  • GC06P031797
  • GC06P031813
  • GC06P031824
  • GC06P031853
  • GC06P031828

Summaries for HSPA1B Gene

Entrez Gene Summary for HSPA1B Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1B Gene

HSPA1B (Heat Shock Protein Family A (Hsp70) Member 1B) is a Protein Coding gene. Diseases associated with HSPA1B include paranoid schizophrenia and acute mountain sickness. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA1A.

UniProtKB/Swiss-Prot for HSPA1B Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1B Gene

Genomics for HSPA1B Gene

Regulatory Elements for HSPA1B Gene

Promoters for HSPA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA1B on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA1B Gene

Chromosome:
6
Start:
31,827,735 bp from pter
End:
31,830,255 bp from pter
Size:
2,521 bases
Orientation:
Plus strand

Genomic View for HSPA1B Gene

Genes around HSPA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1B Gene

  • Protein details for HSPA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV9-HS71B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1B
    Protein Accession:
    P0DMV9
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1B Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486).

    Three dimensional structures from OCA and Proteopedia for HSPA1B Gene

neXtProt entry for HSPA1B Gene

Proteomics data for HSPA1B Gene at MOPED

Post-translational modifications for HSPA1B Gene

No Post-translational modifications

Other Protein References for HSPA1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1B Gene

Domains & Families for HSPA1B Gene

Gene Families for HSPA1B Gene

Protein Domains for HSPA1B Gene

Suggested Antigen Peptide Sequences for HSPA1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DMV9

UniProtKB/Swiss-Prot:

HS71B_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1B: view

Function for HSPA1B Gene

Molecular function for HSPA1B Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1B,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15603737
GO:0055131 C3HC4-type RING finger domain binding IPI 25281747
genes like me logo Genes that share ontologies with HSPA1B: view

Phenotypes for HSPA1B Gene

genes like me logo Genes that share phenotypes with HSPA1B: view

Animal Models for HSPA1B Gene

MGI Knock Outs for HSPA1B:

Animal Model Products

miRNA for HSPA1B Gene

miRTarBase miRNAs that target HSPA1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSPA1B Gene

Localization for HSPA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1B Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1B Gene COMPARTMENTS Subcellular localization image for HSPA1B gene
Compartment Confidence
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HSPA1B: view

Pathways & Interactions for HSPA1B Gene

genes like me logo Genes that share pathways with HSPA1B: view

Interacting Proteins for HSPA1B Gene

Gene Ontology (GO) - Biological Process for HSPA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034605 cellular response to heat IDA,TAS 24061851
GO:0046034 ATP metabolic process IDA 23921388
GO:0050821 protein stabilization TAS 24252804
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP 24790089
GO:0070370 cellular heat acclimation IMP 21231916
genes like me logo Genes that share ontologies with HSPA1B: view

No data available for SIGNOR curated interactions for HSPA1B Gene

Drugs & Compounds for HSPA1B Gene

(1) Drugs for HSPA1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0
genes like me logo Genes that share compounds with HSPA1B: view

Transcripts for HSPA1B Gene

mRNA/cDNA for HSPA1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(326) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSPA1B Gene

Heat shock 70kDa protein 1B:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1B Gene

No ASD Table

Relevant External Links for HSPA1B Gene

GeneLoc Exon Structure for
HSPA1B
ECgene alternative splicing isoforms for
HSPA1B

Expression for HSPA1B Gene

mRNA expression in normal human tissues for HSPA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSPA1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for HSPA1B Gene

This gene is overexpressed in Uterus (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1B Gene



SOURCE GeneReport for Unigene cluster for HSPA1B Gene Hs.719966

mRNA Expression by UniProt/SwissProt for HSPA1B Gene

P0DMV9-HS71B_HUMAN
Tissue specificity: HSPA1B is testis-specific.
genes like me logo Genes that share expression patterns with HSPA1B: view

Protein tissue co-expression partners for HSPA1B Gene

Primer Products

In Situ Assay Products

Orthologs for HSPA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
HSPA1A 35
  • 99.53 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia HSPA1A 36
  • 99 (a)
OneToMany
HSPA1A 35
  • 94.64 (n)
  • 98.75 (a)
dog
(Canis familiaris)
Mammalia LOC102155697 35
  • 94.8 (n)
  • 98.91 (a)
-- 36
  • 99 (a)
ManyToMany
HSPA1 36
  • 98 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hspa1a 16
Hspa1a 36
  • 95 (a)
ManyToMany
Hspa1b 36
  • 95 (a)
ManyToMany
Hspa1a 35
  • 91.52 (n)
  • 95.32 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1a 35
  • 92.3 (n)
  • 96.57 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 35
  • 78.36 (n)
  • 88.36 (a)
zebrafish
(Danio rerio)
Actinopterygii hsp70.2 36
  • 85 (a)
ManyToMany
hsc70 35
  • 75.4 (n)
  • 85.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 36
  • 79 (a)
ManyToMany
Hsc70-4 36
  • 81 (a)
ManyToMany
CG7182 37
  • 27 (a)
Hsc70-1 37
  • 78 (a)
Hsc70-2 37
  • 75 (a)
Hsc70-3 37
  • 62 (a)
Hsc70-4 37
  • 82 (a)
Hsp68 37
  • 73 (a)
Hsp70Aa 37
  • 76 (a)
Hsp70Ab 37
  • 76 (a)
Hsp70Ba 37
  • 77 (a)
Hsp70Bb 37
  • 77 (a)
Hsp70Bc 37
  • 77 (a)
Hsp70Bc 35
  • 74.71 (n)
  • 77.36 (a)
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 68 (a)
F44E5.5 37
  • 68 (a)
hsp-1 37
  • 83 (a)
hsp-2 37
  • 75 (a)
hsp-3 37
  • 61 (a)
hsp-4 37
  • 60 (a)
hsp-70 37
  • 66 (a)
hsp-1 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 35
  • 70.57 (n)
  • 76.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA4 35
  • 63.59 (n)
  • 75.74 (a)
SSA2 36
  • 74 (a)
OneToMany
SSA4 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 35
  • 62.82 (n)
  • 75.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 35
  • 68.52 (n)
  • 76.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 80 (a)
ManyToMany
CSA.971 36
  • 75 (a)
ManyToMany
Species with no ortholog for HSPA1B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1B Gene

ENSEMBL:
Gene Tree for HSPA1B (if available)
TreeFam:
Gene Tree for HSPA1B (if available)

Paralogs for HSPA1B Gene

Paralogs for HSPA1B Gene

(16) SIMAP similar genes for HSPA1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSPA1B: view

Variants for HSPA1B Gene

Sequence variations from dbSNP and Humsavar for HSPA1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs483638 - 31,829,446(+) GGCCA(A/G)CAAGA reference, missense
VAR_032152 -
VAR_032153 -
rs3036297 -- 31,829,993(+) TGTAA(-/AAGTT/AGTTA)AGTTG utr-variant-3-prime
rs6457452 -- 31,827,773(+) GTCCG(C/G/T)TTCGT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HSPA1B Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
dgv6589n71 CNV Loss 21882294
dgv6590n71 CNV Loss 21882294
esv2421830 CNV Deletion 20811451
esv2667397 CNV Deletion 23128226
dgv6591n71 CNV Gain+Loss 21882294
dgv6592n71 CNV Loss 21882294

Variation tolerance for HSPA1B Gene

Gene Damage Index Score: 5.02; 68.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA1B Gene

HapMap Linkage Disequilibrium report
HSPA1B
Human Gene Mutation Database (HGMD)
HSPA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1B Gene

Disorders for HSPA1B Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSPA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paranoid schizophrenia
  • chronic paranoid schizophrenia
acute mountain sickness
  • altitude anoxia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPA1B

Genetic Association Database (GAD)
HSPA1B
Human Genome Epidemiology (HuGE) Navigator
HSPA1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA1B
genes like me logo Genes that share disorders with HSPA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1B Gene

Publications for HSPA1B Gene

  1. Structure and expression of the three MHC-linked HSP70 genes. (PMID: 1700760) Milner C.M. … Campbell R.D. (Immunogenetics 1990) 2 3 4 23 67
  2. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PMID: 18518860) Buraczynska M. … Ksiazek A. (Clin. Sci. 2009) 3 23
  3. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. (PMID: 19085089) Li J.X. … Niu W.Q. (Cell Stress Chaperones 2009) 3 23
  4. The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients. (PMID: 19439993) Pae C.U. … Serretti A. (Neuropsychobiology 2009) 3 23
  5. The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (PMID: 19661373) Tahara T. … Hirata I. (Anticancer Res. 2009) 3 23

Products for HSPA1B Gene

Sources for HSPA1B Gene

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