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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA1B Gene

protein-coding   GIFtS: 65
GCID: GC06P031824

Heat Shock 70kDa Protein 1B

(Previous name: heat shock 70kD protein 1B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 1B1 2     HSP70-1B2
Heat Shock 70kD Protein 1B1 2     HSP70-22
Heat Shock 70 KDa Protein 1/22 3     Heat Shock 70 KDa Protein 1A/1B2
HSP70-1/HSP70-22 3     HSPA13
HSP70.1/HSP70.22 3     

External Ids:    HGNC: 52331   Entrez Gene: 33042   Ensembl: ENSG000002043887   OMIM: 6030125   UniProtKB: P081073   

Export aliases for HSPA1B gene to outside databases

Previous GC identifers: GC06P031867 GC06P031849 GC06P031566 GC06P031899 GC06P031903 GC06P031797 GC06P031813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA1B Gene:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In
conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and
mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the
ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is
located in the major histocompatibility complex class III region, in a cluster with two closely related genes
which encode similar proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSPA1B Gene: 
HSPA1B (heat shock 70kDa protein 1B) is a protein-coding gene. Diseases associated with HSPA1B include acute mountain sickness, and diabetic foot ulcers, and among its related super-pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and MAPK signaling pathway. GO annotations related to this gene include protein N-terminus binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
serves as a post-attachment receptor for the virus to facilitate entry into the cell




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167248.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA1B gene promoter:
         Max1   PPAR-alpha   CP2   STAT3   NF-kappaB   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA1B promoter sequence
   Search SABiosciences Chromatin IP Primers for HSPA1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HSPA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031824:  view genomic region     (about GC identifiers)

Start:
31,795,512 bp from pter      End:
31,798,031 bp from pter
Size:
2,520 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167248 3,089,163-3,091,686      Chr6+,NT_113891.2 3,305,094-3,307,616      Chr6+,NT_167244 3,110,276-3,112,789     
Chr6+,NT_167245 3,081,099-3,083,618     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1A/1B  
Size: 641 amino acids; 70052 Da
Subunit: Component of the CatSper complex (By similarity). Identified in a mRNP granule complex, at least composed
of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1,
ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and
untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in
the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7.
Interacts with CHCHD3. Interacts with TRIM5 (via B30.2/SPRY domain)
Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
6/14 PDB 3D structures from and Proteopedia for HSPA1B (see all 14):
1HJO (3D)        1S3X (3D)        1XQS (3D)        2E88 (3D)        2E8A (3D)        2LMG (3D)    
Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0
Alternative splicing: 2 isoforms:  P08107-1   P08107-2   

Explore the universe of human proteins at neXtProt for HSPA1B: NX_P08107

Explore proteomics data for HSPA1B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08107

  • HSPA1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA1B Protein Expression
    REFSEQ proteins: NP_005337.2  
    ENSEMBL proteins: 
     ENSP00000364801   ENSP00000442789  
    Reactome Protein details: P08107
    Human Recombinant Protein Products for HSPA1B: 
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    ProSpec Recombinant Protein for HSPA1B
    Cloud-Clone Corp. Proteins for HSPA1B 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10205060
    GO:0005737cytoplasm TAS16130169
    GO:0005739mitochondrion TAS16130169
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005829cytosol TAS--

    HSPA1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P08107

    ProtoNet protein and cluster: P08107

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Similarity: Belongs to the heat shock protein 70 family


    HSPA1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP71_HUMAN, P08107
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
    serves as a post-attachment receptor for the virus to facilitate entry into the cell
    Induction: By heat shock

         Genatlas biochemistry entry for HSPA1B:
    heat shock 70kDa protein A1B,acting as a molecular chaperone

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005515protein binding IPI12853476
    GO:0005524ATP binding IEA--
    GO:0031625ubiquitin protein ligase binding IPI15603737
    GO:0044183protein binding involved in protein folding IDA15603737
         
    HSPA1B for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Hspa1b):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  immune system 
     mortality/aging  nervous system  renal/urinary system  reproductive system 

    HSPA1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HSPA1B: Hspa1btm1Bwy Hspa1btm1Jss Hspa1a/Hspa1bHspa1a/tm1Dix Hspa1btm1Clib

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSPA1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA1B 

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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate HSPA1B:
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    SwitchGear 3'UTR luciferase reporter plasmidHSPA1B 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSPA1B About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.87
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    5CFTR folding and maturation (norm and CF)
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)0.37
    CFTR folding and maturation (norm and CF)0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSPA1B
        Development Glucocorticoid receptor signaling
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSPA1B
        Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells
    Cellular Transformation by HTLV1

    5/6 GeneGo (Thomson Reuters) Pathways for HSPA1B (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    5 BioSystems Pathways for HSPA1B
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway
    Apoptosis Modulation by HSP70
    Direct p53 effectors
    FOXM1 transcription factor network

    5        Reactome Pathways for HSPA1B
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Destabilization of mRNA by AUF1 (hnRNP D0)
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression


    5/11         Kegg Pathways  (Kegg details for HSPA1B) (see all 11):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation


    HSPA1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSPA1B

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/572 Interacting proteins for HSPA1B (P081071, 2, 3 ENSP000003648014) via UniProtKB, MINT, STRING, and/or I2D (see all 572)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCAP378402, 3MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-7556901 MINT-8211605 I2D: score=2 
    STUB1Q9UNE71, 2, 3EBI-629985,EBI-357085 MINT-7903424 I2D: score=4 
    AIFM1O958312, 3MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 
    BAG1Q999332, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    HSP90AB1P082382, 3MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006402mRNA catabolic process IDA10205060
    GO:0006986response to unfolded protein IDA10859165
    GO:0008285negative regulation of cell proliferation IMP9553041
    GO:0010467gene expression TAS--

    HSPA1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for HSPA1B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA1B (HSP71)

    Search CenterWatch for drugs/clinical trials and news about HSPA1B / HSP71

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA1B gene: 
    NM_005346.4  

    Unigene Cluster for HSPA1B:

    Heat shock 70kDa protein 1B
    Hs.719966  [show with all ESTs]
    Unigene Representative Sequence: NM_005346
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375650(uc003nxk.2) ENST00000545241
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK295398.1 AK303967.1 AL360193.1 BC001876.1 BC057397.1 BC063507.1 

    24/35 DOTS entries (see all 35):

    DT.309093  DT.100855495  DT.121331306  DT.100695127  DT.91787162  DT.100847810  DT.121331366  DT.100695123 
    DT.100695139  DT.100868791  DT.75141405  DT.100695138  DT.97794033  DT.100057333  DT.121331348  DT.121331533 
    DT.100847514  DT.102841819  DT.95213511  DT.100769435  DT.121331459  DT.121331463  DT.121331479  DT.97862661 

    24/326 AceView cDNA sequences (see all 326):

    D57316 AA386402 AA381832 BX337156 BQ718828 BX388726 CD514945 N71203 
    BG429929 F03271 BQ717293 BE382975 BE305108 BI715436 BX450712 BI712613 
    BM564625 BQ638197 AK096017 AI815405 AI671261 CB216405 BQ716106 BM790717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA1B expression in normal human tissues (normalized intensities)      HSPA1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGCGCCG
    HSPA1B Expression
    About this image


    HSPA1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer

    See HSPA1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA1B

    SOURCE GeneReport for Unigene cluster: Hs.719966

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Tissue specificity: HSPA1B is testis-specific

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA1B (see all 9): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA1B gene from 8/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa1b1 , 5 heat shock protein 1B1, 5 91.58(n)1
    95.32(a)1
      17 (18.50 cM)5
    155111  NM_010478.21  NP_034608.21 
     349564365 
    lizard
    (Anolis carolinensis)
    Reptilia --
    HSPA26
    Uncharacterized protein
    84(a)
    59(a)
    possible ortholog
    possible ortholog
    LGf(897907-924982)
    GL343668.1(269397-271328)
    zebrafish
    (Danio rerio)
    Actinopterygii hsp701 heat shock cognate 70-kd protein 79.2(n)
    86.56(a)
      30671  NM_131397.2  NP_571472.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43
    Hsp70Bc1
    neurotransmitter secretion chaperone3
    Heat-shock-protein-70Bc1
    82(a)
    (best of 11)3
    73.71(n)1
    76.5(a)1
      88E43
    485831  NM_141952.21  NP_650209.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSA4(YER103W)4 Heat shock protein that is highly induced upon stress; more   --   5(364589-366517) 856840  NP_011029.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G094401 protein heat shock protein 70-3 68.08(n)
    76.42(a)
      820102  NM_001202918.1  NP_001189847.1 
    barley
    (Hordeum vulgare)
    Liliopsida L32165.12   -- 75.65(n)    L32165.1 


    ENSEMBL Gene Tree for HSPA1B (if available)
    TreeFam Gene Tree for HSPA1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA1B gene
    HSPA1A1 2  HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA62  HSPA132  HSPA22  
    16 SIMAP similar genes for HSPA1B using alignment to 2 protein entries:     HSP71_HUMAN (see all proteins):
    HSP70-1    HSPA1A    HSPA1L    HSPA2    HSPA6    HSPA7
    LOC401308    HSPA8    HSPA5    HSPA9    HSPA14    HSPA13
    HS24/p52    HSPA4    HSPA4L    HSPH1

    HSPA1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 SNPs in HSPA1B are shown (see all 112)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429195571,2
    --31793527(+) GGCTA-/TTTTTT 1 -- us2k10--------
    rs1411938811,2
    C--31793612(+) TCAGAC/TGCCTA 1 -- us2k10--------
    rs344671491,2
    C,F,H--31793716(+) GAATCC/TGCAGG 1 -- us2k19Minor allele frequency- T:0.01NS NA 600
    rs346148361,2
    C,F--31793781(+) AACCCT/GGTCTC 1 -- us2k15Minor allele frequency- G:0.01NS 158
    rs354409171,2
    C--31793808(+) ATTAGC/ACCGGC 1 -- us2k15Minor allele frequency- A:0.01NS 158
    rs349797181,2
    C--31793832(+) CTGTAA/TTTCCA 1 -- us2k15Minor allele frequency- T:0.01NS 158
    rs413123171,2
    F--31793903(+) GCAGAG/AATCTC 1 -- us2k13Minor allele frequency- A:0.02NA 144
    rs1121320611,2
    --31793996(+) TCACGT/CCTGTA 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs1913176891,2
    --31794044(+) GAGGTC/TAGGAG 1 -- us2k10--------
    rs349642641,2
    C,F--31794086(+) CACGAG/AGTCAG 1 -- us2k15Minor allele frequency- A:0.02NS 180

    HapMap Linkage Disequilibrium report for HSPA1B (31795512 - 31798031 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HSPA1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421830CNV Deletion20811451
    esv2667397CNV Deletion23128226
    dgv6583n71CNV Loss21882294
    dgv6590n71CNV Loss21882294
    dgv6589n71CNV Loss21882294
    dgv6582n71CNV Loss21882294
    dgv6592n71CNV Loss21882294
    dgv6591n71CNV Gain+Loss21882294


    Human Gene Mutation Database (HGMD): HSPA1B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603012    OMIM disorders: --

    20/63 diseases for HSPA1B (see all 63):    About MalaCards
    acute mountain sickness    diabetic foot ulcers    mulibrey nanism    pneumoconiosis
    clostridium difficile    h. pylori infection    pulmonary edema    reactive arthritis
    duodenal ulcer    spondyloarthropathy    duodenitis    allergic asthma
    autoimmune thyroiditis    toxoplasmosis    spondylitis    ankylosing spondylitis
    acute pancreatitis    male infertility    measles    lupus erythematosus


    HSPA1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    8 Novoseek inferred disease relationships for HSPA1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 69.3 36 7901896 (2), 16819288 (2), 7927536 (1), 17110616 (1) (see all 25)
    necrosis 17.6 5 12691826 (1), 15714129 (1), 18580445 (1), 11678832 (1)
    atherosclerotic plaque 12.4 1 16953332 (1)
    lupus erythematosus systemic 12.4 2 11196683 (1), 8655362 (1)
    inflammation 0.608 2 11030172 (1), 19661373 (1)
    tumors 0 6 12691826 (1), 15714129 (1), 18580445 (1)
    melanoma 0 1 9918409 (1)
    cancer 0 10 17363574 (4), 15741319 (4), 19914824 (1)

    Genetic Association Database (GAD): HSPA1B
    Human Genome Epidemiology (HuGE) Navigator: HSPA1B (83 documents)

    Export disorders for HSPA1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA1B gene, integrated from 9 sources (see all 239):
    (articles sorted by number of sources associating them with HSPA1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)1, 2, 3, 9 Milner C.M. and Campbell R.D. (1990)
    2. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)1, 4, 9 Pae C.U....Kim J.J. (2005)
    3. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)1, 4, 9 Temple S.E....Waterer G.W. (2004)
    4. Interaction of serum 70-kDa heat shock protein levels and HspA1B (+1267) gene polymorphism with disease severity in patients with chronic heart failure. (PubMed id 18759004)1, 4, 9 Gombos T....Prohaszka Z. (2008)
    5. Polymorphism of stress protein HSP70-2 gene in Tunisians: susceptibility implications in type 2 diabetes and obesity. (PubMed id 15223990)1, 4, 9 Zouari Bouassida K....Danguir J. (2004)
    6. Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis. (PubMed id 18580445)1, 4, 9 Tukiainen E....Repo H. (2008)
    7. The impact of heat shock protein 70 gene variations o n clinical presentation and outcome in schizophrenic inpatients. (PubMed id 19439993)1, 4, 9 Pae C.U....Serretti A. (2009)
    8. Heat-shock protein gene polymorphisms and the risk of nephropathy in type 2 diabetes patients. (PubMed id 18518860)1, 4, 9 Buraczynska M....Ksiazek A. (2008)
    9. Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients. (PubMed id 16525348)1, 4, 9 Bowers D.J....Lowry S.F. (2006)
    10. Polymorphism of the TNF-alpha, HSP70-2, and CD14 genes increases susceptibility to severe acute pancreatitis. (PubMed id 15714129)1, 4, 9 Balog A....Mandi Y. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3304 HGNC: 5233 AceView: HSPA1AandHSPA1B Ensembl:ENSG00000204388 euGenes: HUgn3304
    ECgene: HSPA1B Kegg: 3304 H-InvDB: HSPA1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA1B gene:
    Search GeneIP for patents involving HSPA1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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