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HSPA1A Gene

protein-coding   GIFtS: 72
GCID: GC06P031850

Heat Shock 70kDa Protein 1A

(Previous name: heat shock 70kD protein 1A)
(Previous symbol: HSPA1)
  See HSPA1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 1A1 2     HSP70-1A2
HSPA11 2 3     HSP70I2
Heat Shock 70kD Protein 1A1 2     HSP722
Heat Shock 70 KDa Protein 1/22 3     DnaK-Type Molecular Chaperone HSP70-12
HSP70-1/HSP70-22 3     Epididymis Secretory Protein Li 1032
HSP70.1/HSP70.22 3     Heat Shock 70 KDa Protein 1A/1B2
HEL-S-1032     Heat Shock-Induced Protein2
HSP70-12     HSX703

External Ids:    HGNC: 52321   Entrez Gene: 33032   Ensembl: ENSG000002043897   OMIM: 1405505   UniProtKB: P081073   

Export aliases for HSPA1A gene to outside databases

Previous GC identifers: GC06P031856 GC06P031836 GC06P031553 GC06P031887 GC06P031891 GC06P031796 GC06P031792 GC06P031801 GC06P031823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSPA1A Gene:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In
conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and
mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the
ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is
located in the major histocompatibility complex class III region, in a cluster with two closely related genes
which encode similar proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSPA1A Gene:
HSPA1A (heat shock 70kDa protein 1A) is a protein-coding gene. Diseases associated with HSPA1A include tuberculoid leprosy, and spinocerebellar ataxia type 6. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
chaperones participate in all these processes through their ability to recognize nonnative conformations of other
proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
serves as a post-attachment receptor for the virus to facilitate entry into the cell

Gene Wiki entry for HSPA1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA1A gene promoter:
         Max1   MyoD   NF-kappaB   PPAR-alpha   CP2   STAT3   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA1A promoter sequence
   Search Chromatin IP Primers for HSPA1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HSPA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P031850:  view genomic region     (about GC identifiers)

Start:
31,783,291 bp from pter      End:
31,785,723 bp from pter
Size:
2,433 bases      Orientation:
plus strand

4 alternative locations:
Chr6+,NT_167248 3,076,938-3,079,366      Chr6+,NT_167245 3,068,878-3,071,306      Chr6+,NT_167244 3,098,052-3,100,480     
Chr6+,NT_113891.2 3,292,871-3,295,299     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 1A/1B  
Size: 641 amino acids; 70052 Da
Subunit: Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing
untranslated mRNAs. Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2. Interacts with TERT; the interaction
occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts
with TRIM5 (via B30.2/SPRY domain). Interacts with METTL21A
Selected PDB 3D structures from and Proteopedia for HSPA1A (see all 16):
1HJO (3D)        1S3X (3D)        1XQS (3D)        2E88 (3D)        2E8A (3D)        2LMG (3D)    
Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0
Alternative splicing: 2 isoforms:  P08107-1   P08107-2   

Explore the universe of human proteins at neXtProt for HSPA1A: NX_P08107

Explore proteomics data for HSPA1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSPA1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005336.3  
    ENSEMBL proteins: 
     ENSP00000477378   ENSP00000364802   ENSP00000402651  
    Reactome Protein details: P08107

    HSPA1A Human Recombinant Protein Products:

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    Novus Biologicals HSPA1A Proteins
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    Sino Biological Recombinant Protein for HSPA1A
    Sino Biological Cell Lysate for HSPA1A
    ProSpec Recombinant Protein for HSPA1A
    Cloud-Clone Corp. Proteins for HSPA1A

     
    Search eBioscience for Proteins for HSPA1A 

     
    antibodies-online proteins for HSPA1A (9 products) 

     
    antibodies-online peptides for HSPA1A

    HSPA1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSPA1A
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    ThermoFisher Antibody for HSPA1A
    antibodies-online antibodies for HSPA1A (69 products) 

    HSPA1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    antibodies-online kits for HSPA1A (24 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry P08107

    ProtoNet protein and cluster: P08107

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Similarity: Belongs to the heat shock protein 70 family


    Find genes that share domains with HSPA1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP71_HUMAN, P08107
    Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and
    mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These
    chaperones participate in all these processes through their ability to recognize nonnative conformations of other
    proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during
    translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection,
    serves as a post-attachment receptor for the virus to facilitate entry into the cell
    Induction: By heat shock

         Genatlas biochemistry entry for HSPA1A:
    heat shock 70kDa protein A1,acting as a molecular chaperone

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity ----
    GO:0003725double-stranded RNA binding ----
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
    GO:0031625ubiquitin protein ligase binding ----
         
    Find genes that share ontologies with HSPA1A           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hspa1a):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  nervous system 
     reproductive system 

    Find genes that share phenotypes with HSPA1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hspa1a/Hspa1bHspa1a/tm1Dix for HSPA1A

       genOway: Develop your customized and physiologically relevant rodent model for HSPA1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA1A:
    hsa-mir-15a-5p (MIRT000866), hsa-mir-335-5p (MIRT018150), hsa-mir-16-5p (MIRT001456), hsa-mir-34a-5p (MIRT025302), hsa-mir-146a-5p (MIRT021244)

    Block miRNA regulation of human, mouse, rat HSPA1A using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSPA1A
    SwitchGear 3'UTR luciferase reporter plasmidHSPA1A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSPA1A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HSPA1A (NM_005345)
    Sino Biological Human cDNA Clone for HSPA1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA1A
    Addgene plasmids for HSPA1A 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA1A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSP71_HUMAN, P08107: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    cytosol4
    extracellular2
    cytoskeleton1
    lysosome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----
    GO:0005783endoplasmic reticulum ----
    GO:0005829cytosol ----

    Find genes that share ontologies with HSPA1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA1A About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    4Influenza A
    Influenza A0.34
    Measles0.34
    5Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59


    Find genes that share SuperPaths with HSPA1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSPA1A
        Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells
    Cellular Transformation by HTLV1

    Selected GeneGo (Thomson Reuters) Pathways for HSPA1A (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    5 BioSystems Pathways for HSPA1A
        MAPK signaling pathway
    Parkin-Ubiquitin Proteasomal System pathway
    Apoptosis Modulation by HSP70
    Direct p53 effectors
    FOXM1 transcription factor network

    1 Sino Biological Pathway for HSPA1A
        Death Receptor Signaling

    5 Reactome Pathways for HSPA1A
        Regulation of HSF1-mediated heat shock response
    AUF1 (hnRNP D0) destabilizes mRNA
    HSF1-dependent transactivation
    Viral RNP Complexes in the Host Cell Nucleus
    Attenuation phase


    Selected Kegg Pathways  (Kegg details for HSPA1A) (see all 12):
        Spliceosome
    MAPK signaling pathway
    Protein processing in endoplasmic reticulum
    Endocytosis
    Antigen processing and presentation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1A (see all 8): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSPA1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA1A (P081071, 2, 3 ENSP000003648024) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCAP378401, 2, 3, ENSP000003383454EBI-629985,EBI-985879 MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-8211605 MINT-7556901 I2D: score=2 STRING: ENSP00000338345
    AIFM1O958312, 3, ENSP000002872954MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 STRING: ENSP00000287295
    HSP90AB1P082382, 3, ENSP000003258754MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000325875
    APEX1P276952, 3, ENSP000002167144MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 STRING: ENSP00000216714
    BAG1Q999332, 3MINT-45860 MINT-45859 MINT-7264729 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006402mRNA catabolic process ----
    GO:0006986response to unfolded protein ----
    GO:0008285negative regulation of cell proliferation ----
    GO:0010467gene expression ----

    Find genes that share ontologies with HSPA1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA1A (HSP71)

    2 HMDB Compounds for HSPA1A    About this table
    CompoundSynonyms CAS #PubMed Ids
    CarnosineBeta-Alanyl-L-histidine (see all 14)305-84-016945336
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for HSPA1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for HSPA1A gene (see all 79)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    delta-12-pgj2 61.1 6 1375619 (3), 8345220 (1)
    17-(allylamino)-17-demethoxygeldanamycin 59.6 1 17409432 (1)
    geranylgeranylacetone 59.1 6 15745966 (3), 19680998 (1), 20133478 (1)
    radicicol 55.5 3 17409432 (1), 15360086 (1)
    polaprezinc 55.2 6 17036391 (2), 16945336 (1)
    quercetin 45.9 24 16201310 (5), 12476615 (2), 12429348 (2), 19112469 (2) (see all 11)
    sodium arsenite 39.6 5 9176145 (3), 10464058 (1), 8647995 (1)
    geldanamycin 38.2 2 11123263 (1), 10843914 (1)
    cyclopentenone 37 2 1375619 (1), 12815164 (1)
    mg 132 35.2 1 15036402 (1)

    1 PharmGKB related drug/compound annotation for HSPA1A gene    About this table
    Drug/compound PharmGKB Annotation
    carbamazepineCA  



    Find genes that share compounds with HSPA1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSPA1A gene: 
    NM_005345.5  

    Unigene Cluster for HSPA1A:

    Heat shock 70kDa protein 1A
    Hs.274402  [show with all ESTs]
    Unigene Representative Sequence: NM_005345
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000608703 ENST00000375651(uc003nxj.3) ENST00000458062
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HSPA1A
      QuantiFast Probe-based Assays in human, mouse, rat HSPA1A

    Additional mRNA sequence: 

    AB209818.1 AK096017.1 AK225692.1 AK225699.1 AK291295.1 AK294182.1 AK298056.1 AK298078.1 
    AK301574.1 AK303980.1 BC002453.2 BC009322.2 BC018740.1 DQ409329.1 

    Selected DOTS entries (see all 58):

    DT.309093  DT.100868791  DT.102841835  DT.91787162  DT.451040  DT.121331459  DT.121331478  DT.121331286 
    DT.121331486  DT.100676892  DT.121331336  DT.121331372  DT.121331530  DT.121331391  DT.121331452  DT.100695125 
    DT.100695127  DT.100695139  DT.121331437  DT.100855495  DT.121331398  DT.121331426  DT.121331479  DT.102841816 

    Selected AceView cDNA sequences (see all 326):

    N71203 BQ640217 CD514945 AA382773 BQ362820 BG429929 BU146273 AI671261 
    BX429885 BQ717293 AW387720 F09929 BF340013 BE305108 BX450712 D54490 
    AA341804 BM505106 D57316 F03271 BM564625 AI815405 F02338 AW627638 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSPA1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGATGAA
    HSPA1A Expression
    About this image


    HSPA1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Pancreas (Endocrine System)
             Duct Cells Pancreatic Ducts
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    HSPA1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.274402

    UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
    Tissue specificity: HSPA1B is testis-specific

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSPA1A (see all 8): 
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Oxidative Stress in human mouse rat
              Apoptosis 384HT in human mouse rat
              Cellular Stress Responses in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSPA1A gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa1a1 , 5 heat shock protein 1A1, 5 91.58(n)1
    95.32(a)1
      17 (18.51 cM)5
    1937401  NM_010479.21  NP_034609.21 
     349691995 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    84(a)
    many ↔ many
    LGf(897907-924982)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004854411 heat shock 70 kDa protein-like 78.31(n)
    88.36(a)
      100485441  XM_002937639.2  XP_002937685.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsp702 heat shock cognate 70-kd protein 77.57(n)   30671  BC056709.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsc70-43
    Hsp70Bc1
    neurotransmitter secretion chaperone3
    Heat-shock-protein-70Bc1
    82(a)
    (best of 11)3
    74.66(n)1
    77.36(a)1
      88E43
    485831  NM_141952.21  NP_650209.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hsp-13 HSP-1 heat shock 70kd protein A 83(a)
    (best of 7)
      IV(17279119-17281340)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSA4(YER103W)4
    SSA41
    Heat shock protein that is highly induced upon stress; more4
    SSA41
    63.59(n)1
    75.74(a)1
      5(364589-366517)4
    8568401, 4  NP_011029.31  NP_011029.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G024901 AT5G02490 68.52(n)
    76.72(a)
      831856  NM_120327.4  NP_195869.1 
    rice
    (Oryza sativa)
    Liliopsida Os.460242 Oryza sativa (japonica cultivar-group) putative HSP7 more 82.03(n)    NM_190528.1 


    ENSEMBL Gene Tree for HSPA1A (if available)
    TreeFam Gene Tree for HSPA1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSPA1A gene
    HSPA1B1 2  HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA62  HSPA142  HSPA22  
    18 SIMAP similar genes for HSPA1A using alignment to 4 protein entries:     HSP71_HUMAN (see all proteins):
    HSPA1B    HSP70-1    HSPA1L    HSPA6    HSPA2    HSPA7
    LOC401308    HSPA8    LOC401309    HSPA5    HSPA9    HS24/P52
    HSPA14    HSPA13    HS24/p52    HSPA4    HSPA4L    HSPH1

    Find genes that share paralogs with HSPA1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA1A (see all 29)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5067701,2
    C,F,A,H--31785228(+) GAGGCC/GGACAA 2 A syn19Minor allele frequency- G:0.28MN NA NS EU 1503
    rs5413401,2
    C,F--31785243(-) TCCAGC/AACCTT 2 /V syn17Minor allele frequency- A:0.04MN NS EU 1463
    rs1913858271,2
    C--31785252(+) GACAAA/GTGTCA 2 K syn10--------
    rs5086031,2
    C,F--31785438(+) GGCCCA/C/G/
            
    ACCAT
    4 P syn1 ese31EU 1069
    rs5086331,2
    C,F--31785453(+) GAGGTA/C/G/
            
    GATTA
    4 V syn14EA NA EU 1331
    rs412697291,2
    C,F--31785675(+) TTTTTT/-AAGTT 1 -- ut315Minor allele frequency- -:0.01NS 180
    rs284708871,2
    C,H--31785792(+) TAAAAT/GGGAAT 1 -- ds50011Minor allele frequency- G:0.00NS 226
    rs412697331,2
    C,F--31785820(+) TAAGGG/ACAGAT 1 -- ds50017Minor allele frequency- A:0.01NS WA NA 418
    rs1487491011,2
    --31786077(+) GGGAGA/GCTGAG 1 -- ds50010--------
    rs93488771,2
    C,F--31786089(+) CAGGAG/AAATCG 1 -- ds50016Minor allele frequency- A:0.06NS EA 300

    HapMap Linkage Disequilibrium report for HSPA1A (31783291 - 31785723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HSPA1A (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2421830CNV Deletion20811451
    esv2667397CNV Deletion23128226
    dgv6583n71CNV Loss21882294
    dgv6590n71CNV Loss21882294
    dgv6589n71CNV Loss21882294
    nsv823504CNV Loss20364138
    dgv6582n71CNV Loss21882294
    dgv6588n71CNV Loss21882294
    dgv6592n71CNV Loss21882294
    nsv482094CNV Gain20164927

    Human Gene Mutation Database (HGMD): HSPA1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA1A
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140550    OMIM disorders: --

    8 diseases for HSPA1A:    
    About MalaCards
    tuberculoid leprosy    spinocerebellar ataxia type 6    carotid artery occlusion    pneumococcal meningitis
    pustulosis palmaris et plantaris    sleep apnea    acute mountain sickness    ischemia

    1 disease from the University of Copenhagen DISEASES database for HSPA1A:
    Vascular disease

    Find genes that share disorders with HSPA1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSPA1A gene (see all 67)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 89.8 366 10718636 (4), 8189235 (4), 9880239 (4), 16572732 (3) (see all 99)
    glioblastoma 41.2 10 9018110 (2), 7594817 (2), 9617483 (2), 7600522 (1) (see all 7)
    myocardial hibernation 40.8 1 12445882 (1)
    ischemia 39.9 36 7604425 (6), 8276180 (3), 8025704 (3), 9566609 (3) (see all 19)
    cell damage 38.7 6 20188818 (1), 12930708 (1), 16036326 (1), 17036391 (1) (see all 6)
    necrosis 31 23 14523009 (2), 15735699 (1), 9395854 (1), 10958679 (1) (see all 20)
    antidiuresis 30.8 1 11125209 (1)
    transient cerebral ischemia 21.4 2 10908039 (2)
    melanoma b16 17.4 2 19157555 (2)
    graves disease 16.8 1 1548334 (1)

    Genetic Association Database (GAD): HSPA1A
    Human Genome Epidemiology (HuGE) Navigator: HSPA1A (60 documents)

    Export disorders for HSPA1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA1A gene, integrated from 10 sources (see all 779):
    (articles sorted by number of sources associating them with HSPA1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in MAcniA"re's disease. (PubMed id 19241595)1, 4, 9 Kawaguchi S....Suzuki M. (Acta Otolaryngol. 2008)
    2. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)1, 4, 9 Temple S.E....Waterer G.W. (Intensive Care Med 2004)
    3. Heat-shock protein gene polymorphisms and the risk of nephropathy in patients with Type 2 diabetes. (PubMed id 18518860)1, 4, 9 Buraczynska M....Ksiazek A. (Clin. Sci. 2009)
    4. Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)1, 2, 9 Milner C.M. and Campbell R.D. (Immunogenetics 1990)
    5. Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer. (PubMed id 19626584)1, 4, 9 Partida-RodrA-guez O....Perez-RodrA-guez M. (Int. J. Cancer 2010)
    6. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)1, 4, 9 Pae C.U....Kim J.J. (Neurosci. Res. 2005)
    7. Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (PubMed id 15832029)1, 4, 9 Fung H.C....Lee-Chen G.J. (Dement Geriatr Cogn Disord 2005)
    8. Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (PubMed id 11779758)1, 4, 9 Vargas-AlarcA^n G....Burgos-Vargas R. (Ann. Rheum. Dis. 2002)
    9. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    10. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. (PubMed id 20498198)1, 4 FA1rnrohr B.G....Voll R.E. (Ann. Rheum. Dis. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3303 HGNC: 5232 AceView: HSPA1AandHSPA1B Ensembl:ENSG00000204389 euGenes: HUgn3303
    ECgene: HSPA1A Kegg: 3303 H-InvDB: HSPA1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSPA1A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hspa1a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA1A gene:
    Search GeneIP for patents involving HSPA1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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