Aliases for HSPA1A Gene
External Ids for HSPA1A Gene
Previous HGNC Symbols for HSPA1A Gene
Previous GeneCards Identifiers for HSPA1A Gene
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSPA1A Gene
HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) is a Protein Coding gene. Diseases associated with HSPA1A include malignant hyperthermia and carotid artery occlusion. Among its related pathways are Gene Expression and Cellular response to heat stress. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA1B.
UniProtKB/Swiss-Prot for HSPA1A Gene
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).