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Aliases for HSPA1A Gene

Aliases for HSPA1A Gene

  • Heat Shock Protein Family A (Hsp70) Member 1A 2 3 5
  • Heat Shock 70kDa Protein 1A 2 3
  • Heat Shock 70 KDa Protein 1 3 4
  • Heat Shock 70kD Protein 1A 2 3
  • HSP70-1 3 4
  • HSP70.1 3 4
  • HSPA1 3 4
  • DnaK-Type Molecular Chaperone HSP70-1 3
  • Epididymis Secretory Protein Li 103 3
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock 70 KDa Protein 1/2 3
  • Heat Shock-Induced Protein 3
  • HSP70-1/HSP70-2 3
  • HSP70.1/HSP70.2 3
  • HEL-S-103 3
  • HSP70-1A 3
  • HSP70I 3
  • HSP72 3
  • HSX70 4

External Ids for HSPA1A Gene

Previous HGNC Symbols for HSPA1A Gene

  • HSPA1

Previous GeneCards Identifiers for HSPA1A Gene

  • GC06P031856
  • GC06P031836
  • GC06P031553
  • GC06P031887
  • GC06P031891
  • GC06P031796
  • GC06P031792
  • GC06P031801
  • GC06P031823
  • GC06P031850
  • GC06P031820
  • GC06P031826

Summaries for HSPA1A Gene

Entrez Gene Summary for HSPA1A Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1A Gene

HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) is a Protein Coding gene. Diseases associated with HSPA1A include Malignant Hyperthermia and Carotid Artery Occlusion. Among its related pathways are Cellular response to heat stress and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and ubiquitin protein ligase binding. An important paralog of this gene is HSPA1B.

UniProtKB/Swiss-Prot for HSPA1A Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

Gene Wiki entry for HSPA1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1A Gene

Genomics for HSPA1A Gene

Regulatory Elements for HSPA1A Gene

Enhancers for HSPA1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPA1A on UCSC Golden Path with GeneCards custom track

Promoters for HSPA1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA1A on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA1A Gene

Chromosome:
6
Start:
31,815,464 bp from pter
End:
31,817,946 bp from pter
Size:
2,483 bases
Orientation:
Plus strand

Genomic View for HSPA1A Gene

Genes around HSPA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSPA1A Gene

  • Protein details for HSPA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMV8-HS71A_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1A
    Protein Accession:
    P0DMV8
    Secondary Accessions:
    • B4E3B6
    • P08107
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1A Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with DNAAF2 (By similarity). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089). Interacts with DNAJC9 (via J domain) (PubMed:17182002). Interacts with ATF5; the interaction protects ATF5 from degradation via proteasome-dependent and caspase-dependent processes (PubMed:22528486).

    Three dimensional structures from OCA and Proteopedia for HSPA1A Gene

    Alternative splice isoforms for HSPA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA1A Gene

Proteomics data for HSPA1A Gene at MOPED

Post-translational modifications for HSPA1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1A Gene

Domains & Families for HSPA1A Gene

Gene Families for HSPA1A Gene

Protein Domains for HSPA1A Gene

Suggested Antigen Peptide Sequences for HSPA1A Gene

Graphical View of Domain Structure for InterPro Entry

P0DMV8

UniProtKB/Swiss-Prot:

HS71A_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA1A: view

Function for HSPA1A Gene

Molecular function for HSPA1A Gene

GENATLAS Biochemistry:
heat shock 70kDa protein A1,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Induction:
By heat shock.

Gene Ontology (GO) - Molecular Function for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15603737
GO:0055131 C3HC4-type RING finger domain binding IPI 25281747
genes like me logo Genes that share ontologies with HSPA1A: view
genes like me logo Genes that share phenotypes with HSPA1A: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA1A Gene

Localization for HSPA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1A Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1A Gene COMPARTMENTS Subcellular localization image for HSPA1A gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HSPA1A: view

Pathways & Interactions for HSPA1A Gene

genes like me logo Genes that share pathways with HSPA1A: view

Interacting Proteins for HSPA1A Gene

SIGNOR curated interactions for HSPA1A Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IEA --
GO:0006281 DNA repair IEA --
GO:0009408 response to heat IEA --
GO:0031397 negative regulation of protein ubiquitination IDA 12150907
GO:0034605 cellular response to heat IDA,TAS 24061851
genes like me logo Genes that share ontologies with HSPA1A: view

Drugs & Compounds for HSPA1A Gene

(42) Drugs for HSPA1A Gene - From: PharmGKB, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 128
Adenosine triphosphate Approved Nutra 0
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0
AIMPILA Pharma 0

(47) Additional Compounds for HSPA1A Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Carnosine
  • b-Alanyl-L-histidine
  • b-Alanylhistidine
  • beta-Alanyl-L-histidine
  • beta-Alanylhistidine
  • Carnosine
305-84-0
BIX
101714-41-4
MKT 077
147366-41-4
Pifithrin-mu
64984-31-2
TRC 051384
867164-40-7

(5) Tocris Compounds for HSPA1A Gene

Compound Action Cas Number
BIX BiP (Hsp70-5) ER chaperone inducer 101714-41-4
MKT 077 Binds mot-2; selectively cytotoxic in cancer cells 147366-41-4
Pifithrin-mu Inhibitor of p53-mitochondrial binding 64984-31-2
TRC 051384 Inducer of heat shock protein Hsp70 867164-40-7
VER 155008 Hsp70 inhibitor 1134156-31-2

(1) ApexBio Compounds for HSPA1A Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA1A: view

Transcripts for HSPA1A Gene

mRNA/cDNA for HSPA1A Gene

Unigene Clusters for HSPA1A Gene

Heat shock 70kDa protein 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1A Gene

No ASD Table

Relevant External Links for HSPA1A Gene

GeneLoc Exon Structure for
HSPA1A
ECgene alternative splicing isoforms for
HSPA1A

Expression for HSPA1A Gene

mRNA expression in normal human tissues for HSPA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA1A Gene

This gene is overexpressed in Uterus (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1A Gene



SOURCE GeneReport for Unigene cluster for HSPA1A Gene Hs.274402

genes like me logo Genes that share expression patterns with HSPA1A: view

Protein tissue co-expression partners for HSPA1A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA1A Gene

Orthologs for HSPA1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA1A 35
  • 94.59 (n)
  • 98.75 (a)
HSPA1A 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC102155697 35
  • 94.8 (n)
  • 98.91 (a)
-- 36
  • 99 (a)
ManyToMany
HSPA1 36
  • 98 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hspa1a 35
  • 91.58 (n)
  • 95.32 (a)
Hspa1a 36
  • 95 (a)
ManyToMany
Hspa1b 36
  • 95 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia HSPA1A 35
  • 99.38 (n)
  • 99.84 (a)
-- 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1a 35
  • 92.36 (n)
  • 96.57 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 35
  • 78.31 (n)
  • 88.36 (a)
zebrafish
(Danio rerio)
Actinopterygii hsc70 35
  • 75.4 (n)
  • 85.92 (a)
hsp70 35
si:ch211-199o1.2 36
  • 86 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11817 35
fruit fly
(Drosophila melanogaster)
Insecta CG7182 37
  • 27 (a)
Hsc70-1 37
  • 78 (a)
Hsc70-2 37
  • 75 (a)
Hsc70-3 37
  • 62 (a)
Hsc70-4 37
  • 82 (a)
Hsp68 37
  • 73 (a)
Hsp70Aa 37
  • 76 (a)
Hsp70Ab 37
  • 76 (a)
Hsp70Ba 37
  • 76 (a)
Hsp70Bb 37
  • 76 (a)
Hsp70Bc 37
  • 76 (a)
Hsp70Bc 35
  • 74.66 (n)
  • 77.36 (a)
Hsc70-1 36
  • 79 (a)
ManyToMany
Hsc70-4 36
  • 81 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F44E5.4 37
  • 68 (a)
F44E5.5 37
  • 68 (a)
hsp-1 37
  • 83 (a)
hsp-2 37
  • 75 (a)
hsp-3 37
  • 62 (a)
hsp-4 37
  • 60 (a)
hsp-70 37
  • 66 (a)
hsp-1 36
  • 82 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 35
  • 70.57 (n)
  • 76.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 35
  • 62.87 (n)
  • 75.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA4 35
  • 63.59 (n)
  • 75.74 (a)
SSA2 36
  • 74 (a)
OneToMany
SSA4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 35
  • 68.52 (n)
  • 76.72 (a)
rice
(Oryza sativa)
Liliopsida Os.46024 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 36
  • 80 (a)
ManyToMany
CSA.971 36
  • 75 (a)
ManyToMany
Species with no ortholog for HSPA1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1A Gene

ENSEMBL:
Gene Tree for HSPA1A (if available)
TreeFam:
Gene Tree for HSPA1A (if available)

Paralogs for HSPA1A Gene

Paralogs for HSPA1A Gene

genes like me logo Genes that share paralogs with HSPA1A: view

Variants for HSPA1A Gene

Sequence variations from dbSNP and Humsavar for HSPA1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_029053 -

Structural Variations from Database of Genomic Variants (DGV) for HSPA1A Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
nsv482094 CNV Gain 20164927
nsv823504 CNV Loss 20364138
dgv6588n71 CNV Loss 21882294
dgv6589n71 CNV Loss 21882294
dgv6590n71 CNV Loss 21882294
esv2421830 CNV Deletion 20811451
esv2667397 CNV Deletion 23128226
dgv6591n71 CNV Gain+Loss 21882294
dgv6592n71 CNV Loss 21882294

Variation tolerance for HSPA1A Gene

Gene Damage Index Score: 8.04; 84.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA1A Gene

Human Gene Mutation Database (HGMD)
HSPA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA1A Gene

Disorders for HSPA1A Gene

MalaCards: The human disease database

(8) MalaCards diseases for HSPA1A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant hyperthermia
  • anesthesia related hyperthermia
carotid artery occlusion
  • occlusion and stenosis of carotid artery
tuberculoid leprosy
  • smooth leprosy
mulibrey nanism
  • muscle-liver-brain-eye nanism
transient cerebral ischemia
  • tia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSPA1A

Genetic Association Database (GAD)
HSPA1A
Human Genome Epidemiology (HuGE) Navigator
HSPA1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA1A
genes like me logo Genes that share disorders with HSPA1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA1A Gene

Publications for HSPA1A Gene

  1. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in MAcniA"re's disease. (PMID: 19241595) Kawaguchi S. … Suzuki M. (Acta Otolaryngol. 2008) 3 23 48 67
  2. Exercise-induced extracellular 72 kDa heat shock protein (Hsp72) stimulates neutrophil phagocytic and fungicidal capacities via TLR-2. (PMID: 19771447) Giraldo E. … Ortega E. (Eur. J. Appl. Physiol. 2010) 3 23
  3. Correlation between clinicopathology and expression of heat shock protein 72 and glycoprotein 96 in human esophageal squamous cell carcinoma. (PMID: 20300187) Wang X. … Lin H. (Clin. Dev. Immunol. 2010) 3 23
  4. Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis. (PMID: 18819021) Chow A.M. … Anderson R.L. (Cell Stress Chaperones 2009) 3 23
  5. Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. (PMID: 19001088) Gabai V.L. … Sherman M.Y. (Mol. Cell. Biol. 2009) 3 23

Products for HSPA1A Gene

Sources for HSPA1A Gene

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