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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSPA1A Gene

protein-coding GIFtS: 72
GCID: GC06P031801

heat shock 70kDa protein 1A

(Previous name: heat shock 70kD protein 1A )
(Previous symbol: HSPA1)

Explore 128 diseases affiliated with
HSPA1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 1A¹ ²		HSP70-1A²
HSPA1¹ ² ³		HSP70I²
HSP70-1¹ ²		HSP72²
Heat Shock 70kD Protein 1A¹ ²		DnaK-Type Molecular Chaperone HSP70-1²
Heat Shock 70 KDa Protein 1/2² ³		Heat Shock 70 KDa Protein 1A/1B²
HSP70-1/HSP70-2² ³		Heat Shock-Induced Protein²
HSP70.1/HSP70.2² ³

External Ids:	HGNC: 5232¹	Entrez Gene: 3303²	Ensembl: ENSG00000204389⁷	OMIM: 140550⁵	UniProtKB: P08107³

Export aliases for HSPA1A gene to outside databases

Previous GC identifers: GC06P031856 GC06P031836 GC06P031553 GC06P031887 GC06P031891 GC06P031796 GC06P031792

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSPA1A:

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In

conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates

the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the

ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located

in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode

similar proteins. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate

the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate

in all these processes through their ability to recognize nonnative conformations of other proteins. They bind

extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane

translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment

receptor for the virus to facilitate entry into the cell

Gene Wiki entry for HSPA1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167248.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSPA1A gene promoter:
Max1 MyoD NF-kappaB PPAR-alpha CP2 STAT3 NF-kappaB1 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSPA1A promoter sequence

Search SABiosciences Chromatin IP Primers for HSPA1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

HSPA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA1A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P031801: view genomic region (about GC identifiers)

Start:	31,783,291 bp from pter	End:	31,785,723 bp from pter
Size:	2,433 bases	Orientation:	plus strand

4 alternative locations:

Chr6+,ALT_REF_LOCI_2 31,770,617-31,812,283	Chr6+,ALT_REF_LOCI_1 31,794,605-31,805,383	Chr6+,ALT_REF_LOCI_3 31,765,431-31,778,947
Chr6+,ALT_REF_LOCI_6 31,773,491-31,811,550

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)

Recommended Name: Heat shock 70 kDa protein 1A/1B

Size: 641 amino acids; 70052 Da

Subunit: Component of the CatSper complex (By similarity). Identified in a mRNP granule complex, at least composed of

ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2,

ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and

untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the

absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts

with CHCHD3. Interacts with TRIM5 (via B30.2/SPRY domain)

Subcellular location: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs

6/14 PDB 3D structures from and Proteopedia for HSPA1A (see all 14):

1HJO (3D)

1S3X (3D)

1XQS (3D)

2E88 (3D)

2E8A (3D)

2LMG (3D)

Secondary accessions: B4E3B6 P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0

Alternative splicing: 2 isoforms: P08107-1 P08107-2

Explore the universe of human proteins at neXtProt for HSPA1A: NX_P08107

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P08107

HSPA1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005336.3

ENSEMBL proteins:

ENSP00000364803 ENSP00000364802 ENSP00000402651

Reactome Protein details: P08107
Human Recombinant Protein Products:

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	Novus Biologicals HSPA1A Proteins Novus Biologicals HSPA1A Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HSPA1A
	Uscn Proteins for HSPA1A

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	--	--
GO:0005783	endoplasmic reticulum	--	--
GO:0005829	cytosol	--	--

HSPA1A for ontologies About GeneDecksing

HSPA1A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies (see all 16): HSPA1A OriGene Custom Antibody Services for HSPA1A
	GenScript Superior Antibodies for HSPA1A
	Novus Biologicals HSPA1A Antibodies
	Abcam antibodies for HSPA1A
	Uscn Antibodies for HSPA1A
	ThermoFisher Antibody for HSPA1A

Assay Products for HSPA1A:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSPA1A
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HSPA1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSPA1A for domains About GeneDecksing

2 InterPro domains/families:

IPR018181 Heat_shock_70_CS

IPR013126 Hsp_70_fam

Graphical View of Domain Structure for InterPro Entry P08107

ProtoNet protein and cluster: P08107

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Similarity: Belongs to the heat shock protein 70 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate

the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate

in all these processes through their ability to recognize nonnative conformations of other proteins. They bind

extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane

translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment

receptor for the virus to facilitate entry into the cell

Induction: By heat shock

Genatlas biochemistry entry for HSPA1A:

heat shock 70kDa protein A1,acting as a molecular chaperone

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		OriGene 3'-UTR Clone: HSPA1A Browse MicroRNA Expression Plasmids
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		SwitchGear 3'UTR luciferase reporter plasmid: HSPA1A 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSPA1A (see all 4) OriGene shRNA RFP: HSPA1A OriGene siRNA: HSPA1A
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSPA1A

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA1A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPA1A (NM_005345)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSPA1A
		Search LifeMap BioReagents cell lines for HSPA1A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA1A

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	--	--
GO:0031625	ubiquitin protein ligase binding	--	--
GO:0044183	protein binding involved in protein folding	--	--

HSPA1A for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Hspa1a/Hspa1b^{Hspa1a/tm1Dix} for HSPA1A
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hspa1a):

cardiovascular system	cellular	growth/size	homeostasis/metabolism	nervous system
reproductive system

HSPA1A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Proteolysis Putative ubiquitin pathway

Proteolysis Putative ubiquitin pathway

1.00

Proteolysis_Putative ubiquitin pathway

0.97

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

Measles

Measles

1.00

Influenza A

0.35

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSPA1A

	Development Glucocorticoid receptor signaling
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSPA1A

	Glucocorticoid Receptor Signaling
	HIF1Alpha Pathway
	Aldosterone Signaling in Epithelial Cells
	Cellular Transformation by HTLV1

5/6 GeneGo (Thomson Reuters) Pathways for HSPA1A (see all 6)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Regulation of degradation of deltaF508 CFTR in CF
	CFTR folding and maturation (norm and CF)
	Proteolysis Putative ubiquitin pathway

5 BioSystems Pathways for HSPA1A

	MAPK signaling pathway
	Apoptosis Modulation by HSP70
	Parkin-Ubiquitin Proteasomal System pathway
	FOXM1 transcription factor network
	Direct p53 effectors

5/6 Reactome Pathways for HSPA1A (see all 6)

	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Ubiquitination of AUF1 (hnRNP D0)
	Destabilization of mRNA by AUF1 (hnRNP D0)
	Metabolism of RNA
	Metabolism of mRNA

5/9 Kegg Pathways (Kegg details for HSPA1A) (see all 9):

	Spliceosome
	MAPK signaling pathway
	Protein processing in endoplasmic reticulum
	Endocytosis
	Antigen processing and presentation

HSPA1A for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSPA1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/569 Interacting proteins for HSPA1A (P08107^{1, 2, 3} ENSP00000364802⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 569)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SNCA	P37840²^,³, ENSP00000338345⁴	MINT-7557217 MINT-7555062 MINT-7556887 MINT-8211515 MINT-8211560 MINT-7556911 MINT-7556921 MINT-7556901 MINT-8211605 I2D: score=2 STRING: ENSP00000338345
AIFM1	O95831²^,³, ENSP00000287295⁴	MINT-13840 MINT-13841 MINT-8079030 I2D: score=7 STRING: ENSP00000287295
APEX1	P27695²^,³, ENSP00000216714⁴	MINT-16427 MINT-16428 MINT-8076071 I2D: score=3 STRING: ENSP00000216714
BAG1	Q99933²^,³	MINT-45860 MINT-45859 MINT-7264729 I2D: score=4
HSP90AB1	P08238²^,³	MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006402	mRNA catabolic process	--	--
GO:0006950	response to stress	--	--
GO:0006986	response to unfolded protein	--	--
GO:0008285	negative regulation of cell proliferation	--	--
GO:0010467	gene expression	--	--

HSPA1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSPA1A for compounds About GeneDecksing

EMD Millipore small molecules for HSPA1A:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSPA1A

2 HMDB Compounds for HSPA1A About this table

Compound	Synonyms	CAS #	PubMed Ids
Carnosine	Beta-Alanyl-L-histidine (see all 14)	305-84-0	16945336
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

1 DrugBank Compound for HSPA1A About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	17139284 17016423

10/79 Novoseek chemical compound relationships for HSPA1A gene (see all 79) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
delta-12-pgj2	61.1	6	1375619 (3), 8345220 (1)
17-(allylamino)-17-demethoxygeldanamycin	59.6	1	17409432 (1)
geranylgeranylacetone	59.1	6	15745966 (3), 19680998 (1), 20133478 (1)
radicicol	55.5	3	17409432 (1), 15360086 (1)
polaprezinc	55.2	6	17036391 (2), 16945336 (1)
quercetin	45.9	24	16201310 (5), 12476615 (2), 12429348 (2), 19112469 (2) (see all 11)
sodium arsenite	39.6	5	9176145 (3), 10464058 (1), 8647995 (1)
geldanamycin	38.2	2	11123263 (1), 10843914 (1)
cyclopentenone	37	2	1375619 (1), 12815164 (1)
mg 132	35.2	1	15036402 (1)

1 PharmGKB related drug/compound annotation for HSPA1A gene

Drug/compound	PharmGKB Annotation
carbamazepine	CA

About this table

Search CenterWatch for drugs/clinical trials and news about HSPA1A / HSP71

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSPA1A gene:

NM_005345.5

Unigene Clusters for HSPA1A:

Heat shock 70kDa protein 1A

Hs.274402 [show with all ESTs], Hs.702139 [show with all ESTs]

Unigene Representative Sequences: NM_005345, AK304652

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375652(uc003nxi.1) ENST00000375651(uc003nxj.3) ENST00000458062

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSPA1A

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSPA1A (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSPA1A (NM_005345)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA1A

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSPA1A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA1A

Additional cDNA sequence:

AK301243.1 AK304618.1 AK304652.1

24/98 DOTS entries (see all 98):

DT.309093 DT.100868791 DT.102841835 DT.91787162 DT.451040 DT.121331459 DT.121331478 DT.121331286

DT.100855495 DT.121331486 DT.100676892 DT.121331336 DT.100695139 DT.121331372 DT.100695127 DT.121331479

DT.121331530 DT.121331391 DT.121331437 DT.121331452 DT.100695138 DT.121331276 DT.100057333 DT.100695125

24/326 AceView cDNA sequences (see all 326):

BF340013 BQ716106 BM790717 BI715436 BE382975 AW627638 BE305108 F02338

AI815405 F09929 BQ717293 AW387720 BX429885 BG429929 BQ362820 BU146273

AI671261 AA382773 CA776954 BX388726 BX450712 BQ718828 BI712613 AK096017

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSPA1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAGATGAA

About this image

HSPA1A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Eye

Outer Nuclear Layer

Mature Rod Cells

Photoreceptors, Retina

Somite

Thoracic Ventrolateral Dermomyotome Lip

Muscle Progenitor Cells

Skeletal Muscle

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HSPA1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSPA1A

SOURCE GeneReport for Unigene clusters: Hs.274402 Hs.702139

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Tissue specificity: HSPA1B is testis-specific

SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA1A (see all 8):

Toll-Like Receptor Signaling Pathway in human mouse rat

Oxidative Stress in human mouse rat

Apoptosis 384HT in human mouse rat

Cellular Stress Responses in human mouse rat

Stress & Toxicity PathwayFinder in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1A gene from 5/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
zebrafish (Danio rerio)	Actinopterygii	hsp70²	heat shock cognate 70-kd protein	77.57(n)	30671 BC056709.1
fruit fly (Drosophila melanogaster)	Insecta	Hsc70-4³ Hsp70Bc¹	neurotransmitter secretion chaperone³ Heat-shock-protein-70Bc¹	82(a) (best of 11)³ 73.66(n)¹ 76.5(a)¹	88E4³ 48583¹ NM_141952.2¹ NP_650209.1¹
worm (Caenorhabditis elegans)	Secernentea	hsp-1³	HSP-1 heat shock 70kd protein A	83(a) (best of 7)	IV(17279119-17281340) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G09440¹	protein heat shock protein 70-3	68.13(n) 76.42(a)	820102 NM_001202918.1 NP_001189847.1
rice (Oryza sativa)	Liliopsida	Os.46024²	Oryza sativa (japonica cultivar-group) putative HSP7 more	82.03(n)	NM_190528.1

ENSEMBL Gene Tree for HSPA1A (if available)
TreeFam Gene Tree for HSPA1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSPA1A gene

HSPA1B¹ ² HSPA8² HSPA5² HSPA1L² HSPA6² HSPA14² HSPA13²

18/19 SIMAP similar genes for HSPA1A using alignment to 5 protein entries: HSP71_HUMAN (see all proteins) (see all similar genes):

HSP70-1 HSPA1B LOC401308 HSPA8 LOC401309 HSPA6

HSPA1L HSPA2 HSPA7 HSPA5 HSPA9 HS24/P52

HSPA14 HYOU1 HSPA4L HSPA13 HS24/p52 HSPA4

HSPA1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35804213^1,2	C,	--	31781362(-)	`GCTCAT/CGCCTG`	6	--	int¹ us2k¹		6		NS WA	292
rs35858615^1,2	C,F,	--	31781381(-)	`TAGGCC/TGGGTG`	6	--	int¹ us2k¹		7		NS WA	294
rs34791928^1,2	C,F,H,	--	31781398(-)	`GATAAG/ACAAAA`	6	--	us2k¹ int¹		10		EA NS	804
rs143511779^1,2		--	31781608(+)	`GTCCTA/GTTCCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs35995919^1,2	C,F	--	31781613(-)	`TATATA/GGGAAC`	6	--	int¹ us2k¹		10		NS	368
rs34053064^1,2	C,F,H	--	31781748(-)	`ACTGCC/TGGTGA`	6	--	int¹ us2k¹		12		NS	694
rs35233959^1,2	C,	--	31781833(-)	`AGATAC/TTGTCT`	6	--	int¹ us2k¹		10		NS	360
rs12213612^1,2	C,F,	--	31781957(+)	`gaggcG/Aggcgg`	6	--	int¹ us2k¹		7		NS NA WA	178
rs34431565^1,2	C,F,	--	31782180(-)	`GCCTTC/ACGAGT`	6	--	int¹ us2k¹		5		NS	190
rs35207553^1,2	C,F	--	31782317(-)	`TTTTTA/TTTTAT`	6	--	us2k¹ int¹		5		NS	188

HapMap Linkage Disequilibrium report for HSPA1A (31783291 - 31785723 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSPA1A
1 CNV: 93633
Human Gene Mutation Database (HGMD): HSPA1A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSPA1A for disorders           About GeneDecksing

OMIM gene information: 140550    OMIM disorders: --

20/128 diseases for HSPA1A (see all 128):    About MalaCards

open-angle glaucoma transient cerebral ischemia spinocerebellar ataxia type 6 acute mountain sickness

tuberculoid leprosy carotid artery occlusion non-small cell lung carcinoma sleep apnea

clostridium difficile febrile convulsions coronary heart disease spinocerebellar ataxia

xeroderma pigmentosum chronic obstructive pulmonary disease malignant hyperthermia insulin resistance

ankylosing spondylitis essential hypertension diabetic ketoacidosis ischemic heart disease

1 disease from the University of Copenhagen DISEASES database for HSPA1A:

Vascular disease

10/67 Novoseek disease relationships for HSPA1A gene (see all 67) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	89.8	366	10718636 (4), 8189235 (4), 9880239 (4), 16572732 (3) (see all 99)
glioblastoma	41.2	10	9018110 (2), 7594817 (2), 9617483 (2), 7600522 (1) (see all 7)
myocardial hibernation	40.8	1	12445882 (1)
ischemia	39.9	36	7604425 (6), 8276180 (3), 8025704 (3), 9566609 (3) (see all 19)
cell damage	38.7	6	20188818 (1), 12930708 (1), 16036326 (1), 17036391 (1) (see all 6)
necrosis	31	23	14523009 (2), 15735699 (1), 9395854 (1), 10958679 (1) (see all 20)
antidiuresis	30.8	1	11125209 (1)
transient cerebral ischemia	21.4	2	10908039 (2)
melanoma b16	17.4	2	19157555 (2)
graves disease	16.8	1	1548334 (1)

Genetic Association Database (GAD): HSPA1A
Human Genome Epidemiology (HuGE) Navigator: HSPA1A (60 documents)

Export disorders for HSPA1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HSPA1A gene, integrated from 9 sources (see all 711):
(articles sorted by number of sources associating them with HSPA1A)

Utopia: connect your pdf to the dynamic
world of online information

The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)^{1, 4, 9} Temple S.E....Waterer G.W. (2004)
Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)^{1, 2, 9} Milner C.M. and Campbell R.D. (1990)
Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)^{1, 4, 9} Pae C.U....Kim J.J. (2005)
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (PubMed id 15832029)^{1, 4, 9} Fung H.C....Lee-Chen G.J. (2005)
Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (PubMed id 11779758)^{1, 4, 9} Vargas-Alarcon G....Burgos-Vargas R. (2002)
Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms? (PubMed id 16202503)^{1, 4} Fekete A....Rigo J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. (PubMed id 15963462)^{1, 2} Nellist M....Luider T.M. (2005)
Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population. (PubMed id 16333988)^{1, 4} Zhou F....Wu T. (2005)
[Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness] (PubMed id 15748471)^{1, 4} Li F.Z....Wu T.C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3303	HGNC: 5232	AceView: HSPA1AandHSPA1B	Ensembl:ENSG00000204389	euGenes: HUgn3303
ECgene: HSPA1A	Kegg: 3303	H-InvDB: HSPA1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSPA1A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSPA1A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa1a/

Intellectual Property for HSPA1A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HSPA1A gene:
Search GeneIP for patents involving HSPA1A

GeneCards and IP:
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HSPA1A Gene

heat shock 70kDa protein 1A

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HSPA1A Gene

heat shock 70kDa protein 1A

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