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Aliases for HSPA1A Gene

Aliases for HSPA1A Gene

  • Heat Shock 70kDa Protein 1A 2 3
  • Heat Shock 70 KDa Protein 1/2 3 4
  • Heat Shock 70kD Protein 1A 2 3
  • HSP70-1/HSP70-2 3 4
  • HSP70.1/HSP70.2 3 4
  • HSPA1 3 4
  • DnaK-Type Molecular Chaperone HSP70-1 3
  • Epididymis Secretory Protein Li 103 3
  • Heat Shock 70 KDa Protein 1A/1B 3
  • Heat Shock-Induced Protein 3
  • HSPA1A HSPA1B 4
  • HEL-S-103 3
  • HSP70-1A 3
  • HSP70-1 3
  • HSP70I 3
  • HSP72 3
  • HSX70 4

External Ids for HSPA1A Gene

Previous Symbols for HSPA1A Gene

  • HSPA1

Summaries for HSPA1A Gene

Entrez Gene Summary for HSPA1A Gene

  • This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA1A Gene

HSPA1A (Heat Shock 70kDa Protein 1A) is a Protein Coding gene. Diseases associated with HSPA1A include tuberculoid leprosy and pustulosis palmaris et plantaris. Among its related pathways are MAPK signaling pathway and Endocytosis. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA1A Gene

  • In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).

Gene Wiki entry for HSPA1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA1A Gene

Genomics for HSPA1A Gene

Genomic Location for HSPA1A Gene

Start:
31,815,464 bp from pter
End:
31,817,946 bp from pter
Size:
2,483 bases
Orientation:
Plus strand

Genomic View for HSPA1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HSPA1A Gene

Proteins for HSPA1A Gene

  • Protein details for HSPA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08107-HSP71_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 1A/1B
    Protein Accession:
    P08107
    Secondary Accessions:
    • B4E3B6
    • P19790
    • Q5JQI4
    • Q5SP17
    • Q9UQL9
    • Q9UQM0

    Protein attributes for HSPA1A Gene

    Size:
    641 amino acids
    Molecular mass:
    70052 Da
    Quaternary structure:
    • Component of the CatSper complex. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with CHCHD3, DNAJC7, IRAK1BP1, PPP5C and TSC2 (PubMed:21081504, PubMed:12853476, PubMed:18620420, PubMed:17233114, PubMed:15383005, PubMed:15963462). Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed (PubMed:11274138). Interacts with TRIM5 (via B30.2/SPRY domain) (PubMed:20053985). Interacts with METTL21A (PubMed:23921388). Interacts with PARK2 (PubMed:24270810). Interacts with FOXP3 (PubMed:23973223). Interacts with NOD2; the interaction enhances NOD2 stability (PubMed:24790089).

    Three dimensional structures from OCA and Proteopedia for HSPA1A Gene

    Alternative splice isoforms for HSPA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSPA1A Gene

Proteomics data for HSPA1A Gene at MOPED

Post-translational modifications for HSPA1A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys3, Lys56, Lys71, Lys77, Lys88, Lys102, Lys108, Lys112, Lys126, Lys159, Lys246, Lys319, Lys328, Lys348, Lys361, Lys423, Lys451, Lys497, Lys500, Lys507, Lys512, Lys524, Lys526, Lys539, Lys550, Lys559, Lys561, Lys597, and Lys628

Other Protein References for HSPA1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA1A Gene

Domains for HSPA1A Gene

Gene Families for HSPA1A Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA1A Gene

UniProtKB/Swiss-Prot:

HSP71_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • P08107
genes like me logo Genes that share domains with HSPA1A: view

Function for HSPA1A Gene

Molecular function for HSPA1A Gene

GENATLAS Biochemistry: heat shock 70kDa protein A1,acting as a molecular chaperone
UniProtKB/Swiss-Prot Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).
UniProtKB/Swiss-Prot Induction: By heat shock

Gene Ontology (GO) - Molecular Function for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0001664 G-protein coupled receptor binding IPI 12150907
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 12853476
GO:0005524 ATP binding IDA 23921388
genes like me logo Genes that share ontologies with HSPA1A: view
genes like me logo Genes that share phenotypes with HSPA1A: view

Animal Models for HSPA1A Gene

MGI Knock Outs for HSPA1A:

miRNA for HSPA1A Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSPA1A Gene

Localization for HSPA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA1A Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA1A Gene COMPARTMENTS Subcellular localization image for HSPA1A gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex IDA 12150907
GO:0005634 nucleus IDA 10205060
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005739 mitochondrion TAS 16130169
genes like me logo Genes that share ontologies with HSPA1A: view

Pathways for HSPA1A Gene

genes like me logo Genes that share pathways with HSPA1A: view

Gene Ontology (GO) - Biological Process for HSPA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006200 obsolete ATP catabolic process --
GO:0006402 mRNA catabolic process IDA 10205060
GO:0006986 response to unfolded protein IDA 10859165
GO:0008285 negative regulation of cell proliferation IMP 9553041
genes like me logo Genes that share ontologies with HSPA1A: view

Compounds for HSPA1A Gene

(2) HMDB Compounds for HSPA1A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Carnosine
  • Beta-Alanyl-L-histidine
305-84-0

(1) Drugbank Compounds for HSPA1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Adenosine-5'-Diphosphate
20398-34-9 target

(79) Novoseek inferred chemical compound relationships for HSPA1A Gene

Compound -log(P) Hits PubMed IDs
delta-12-pgj2 61.1 4
17-(allylamino)-17-demethoxygeldanamycin 59.6 1
geranylgeranylacetone 59.1 5
radicicol 55.5 2
polaprezinc 55.2 3

(1) PharmGKB related drug/compound annotations for HSPA1A Gene

Drug/compound Annotation
carbamazepine CA
genes like me logo Genes that share compounds with HSPA1A: view

Transcripts for HSPA1A Gene

mRNA/cDNA for HSPA1A Gene

Unigene Clusters for HSPA1A Gene

Heat shock 70kDa protein 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA1A Gene

No ASD Table

Relevant External Links for HSPA1A Gene

GeneLoc Exon Structure for
HSPA1A
ECgene alternative splicing isoforms for
HSPA1A

Expression for HSPA1A Gene

mRNA expression in normal human tissues for HSPA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA1A Gene

SOURCE GeneReport for Unigene cluster for HSPA1A Gene Hs.274402

mRNA Expression by UniProt/SwissProt for HSPA1A Gene

P08107-HSP71_HUMAN
Tissue specificity: HSPA1B is testis-specific
genes like me logo Genes that share expressions with HSPA1A: view

Orthologs for HSPA1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSPA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
OneToMany
HSPA1A 36
  • 99.38 (n)
  • 99.84 (a)
cow
(Bos Taurus)
Mammalia HSPA1A 36
  • 94.59 (n)
  • 98.75 (a)
HSPA1A 37
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 99 (a)
ManyToMany
HSPA1 37
  • 98 (a)
ManyToMany
LOC102155697 36
  • 94.8 (n)
  • 98.91 (a)
mouse
(Mus musculus)
Mammalia Hspa1a 36
  • 91.58 (n)
  • 95.32 (a)
Hspa1a 16
Hspa1a 37
  • 95 (a)
ManyToMany
Hspa1b 37
  • 95 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa1a 36
  • 92.36 (n)
  • 96.57 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485441 36
  • 78.31 (n)
  • 88.36 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11817 36
zebrafish
(Danio rerio)
Actinopterygii hsc70 36
  • 75.4 (n)
  • 85.92 (a)
hsp70 36
si:ch211-199o1.2 37
  • 86 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Hsc70-1 37
  • 79 (a)
ManyToMany
Hsc70-4 37
  • 81 (a)
ManyToMany
Hsp70Bc 36
  • 74.66 (n)
  • 77.36 (a)
Hsc70-4 38
  • 82 (a)
Hsc70-3 38
  • 62 (a)
Hsp70Aa 38
  • 76 (a)
Hsc70-1 38
  • 78 (a)
Hsp70Bb 38
  • 76 (a)
Hsp70Bc 38
  • 76 (a)
Hsc70-2 38
  • 75 (a)
Hsp68 38
  • 73 (a)
Hsp70Ba 38
  • 76 (a)
CG7182 38
  • 27 (a)
Hsp70Ab 38
  • 76 (a)
worm
(Caenorhabditis elegans)
Secernentea hsp-1 37
  • 82 (a)
OneToMany
F44E5.4 38
  • 68 (a)
hsp-70 38
  • 66 (a)
F44E5.5 38
  • 68 (a)
hsp-3 38
  • 62 (a)
hsp-1 38
  • 83 (a)
hsp-4 38
  • 60 (a)
hsp-2 38
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER187W 36
  • 70.57 (n)
  • 76.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 37
  • 74 (a)
OneToMany
SSA4 36
  • 63.59 (n)
  • 75.74 (a)
SSA4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20527g 36
  • 62.87 (n)
  • 75.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02490 36
  • 68.52 (n)
  • 76.72 (a)
rice
(Oryza sativa)
Liliopsida Os.46024 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11098 37
  • 80 (a)
ManyToMany
CSA.971 37
  • 75 (a)
ManyToMany
Species with no ortholog for HSPA1A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA1A Gene

ENSEMBL:
Gene Tree for HSPA1A (if available)
TreeFam:
Gene Tree for HSPA1A (if available)

Paralogs for HSPA1A Gene

Paralogs for HSPA1A Gene

genes like me logo Genes that share paralogs with HSPA1A: view

Variants for HSPA1A Gene

Sequence variations from dbSNP and Humsavar for HSPA1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_029053 -
VAR_029054 -
VAR_032152 -
VAR_032153 -

Structural Variations from Database of Genomic Variants (DGV) for HSPA1A Gene

Variant ID Type Subtype PubMed ID
dgv6582n71 CNV Loss 21882294
dgv6583n71 CNV Loss 21882294
nsv482094 CNV Gain 20164927
nsv823504 CNV Loss 20364138
dgv6588n71 CNV Loss 21882294
dgv6589n71 CNV Loss 21882294
dgv6590n71 CNV Loss 21882294
esv2421830 CNV Deletion 20811451
esv2667397 CNV Deletion 23128226
dgv6591n71 CNV Gain+Loss 21882294
dgv6592n71 CNV Loss 21882294

Relevant External Links for HSPA1A Gene

HapMap Linkage Disequilibrium report
HSPA1A
Human Gene Mutation Database (HGMD)
HSPA1A

Disorders for HSPA1A Gene

(1) University of Copenhagen DISEASES for HSPA1A Gene

(67) Novoseek inferred disease relationships for HSPA1A Gene

Disease -log(P) Hits PubMed IDs
shock 89.8 163
glioblastoma 41.2 10
myocardial hibernation 40.8 1
ischemia 39.9 32
cell damage 38.7 6

Relevant External Links for HSPA1A

Genetic Association Database (GAD)
HSPA1A
Human Genome Epidemiology (HuGE) Navigator
HSPA1A
genes like me logo Genes that share disorders with HSPA1A: view

No data available for UniProtKB/Swiss-Prot for HSPA1A Gene

Publications for HSPA1A Gene

  1. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PMID: 15232679) Temple S.E. … Waterer G.W. (Intensive Care Med 2004) 3 23 49
  2. Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (PMID: 15832029) Fung H.C. … Lee-Chen G.J. (Dement Geriatr Cogn Disord 2005) 3 23 49
  3. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PMID: 15963589) Pae C.U. … Kim J.J. (Neurosci. Res. 2005) 3 23 49
  4. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in MAcniA"re's disease. (PMID: 19241595) Kawaguchi S. … Suzuki M. (Acta Otolaryngol. 2008) 3 23 49
  5. Expression of intracellular cytokines, HSP72, and apoptosis in monocyte subsets during exertional heat stress in trained and untrained individuals. (PMID: 19158413) Selkirk G.A. … Rhind S.G. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2009) 3 23

Products for HSPA1A Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSPA1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA1A
    • Block miRNA regulation of HSPA1A using miScript Target Protectors

    Sources for HSPA1A Gene

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