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HSPA1A Gene

protein-coding GIFtS: 69

GC06P031891

heat shock 70kDa protein 1A
(Previous name: heat shock 70kD protein 1A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HSPA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ54303 ^²
FLJ54370 ^²
FLJ54392 ^²
FLJ54408 ^²
FLJ75127 ^²
HSP70-1 ^¹, ²
HSP70-1/HSP70-2 ^³
HSP70-1A ^²
HSP70.1 ^³
HSP70I ^²
HSP72 ^²
HSPA1 ^², ³
HSPA1B ^²
OTTHUMP00000029287 ^²

Descriptions
dnaK-type molecular chaperone HSP70-1 ^²
heat shock 70kD protein 1A ^¹, ²
heat shock 70kDa protein 1A ^²
heat shock 70kDa protein 1B ^²
heat shock-induced protein ^²

External Ids
HGNC: 5232¹
Entrez Gene: 3303²
UniProtKB: P08107³
Ensembl: ENSG00000204389⁷

Search outside databases for aliases for HSPA1A gene

Previous GC identifers: GC06P031856 GC06P031836 GC06P031553 GC06P031887

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HSPA1A:

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein

70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins

against aggregation and mediates the folding of newly translated proteins in the cytosol and in

organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the

AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex

class III region, in a cluster with two closely related genes which encode similar proteins.

[provided by RefSeq]

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against

aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as

within organelles. These chaperones participate in all these processes through their ability to

recognize nonnative conformations of other proteins. They bind extended peptide segments with a

net hydrophobic character exposed by polypeptides during translation and membrane translocation,

or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment

receptor for the virus to facilitate entry into the cell

Gene Wiki entry for HSPA1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HSPA1A gene

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.3

HSPA1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P031891: (about GC identifiers)

Start:	31,891,299 bp from pter
End:	31,893,702 bp from pter
Size:	2,404 bases
Orientation:	plus strand

2 alternative locations:

Chr6+,c6_COX 31,917,967-31,920,349

Chr6+,c6_QBL 31,916,440-31,918,822

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113895.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107 (See protein sequence)

Recommended Name: Heat shock 70 kDa protein 1

Size: 641 amino acids; 70052 Da

Subunit: HSPA1B is found in a sperm-specific complex with CATSPER1 and CATSPERB (By similarity).

Interacts with TSC2. Interacts with IRAK1BP1

PDB structures from and Proteopedia :

1HJO (3D)

1S3X (3D)

1XQS (3D)

2E88 (3D)

2E8A (3D)

3D2E (3D)

3D2F (3D)

Secondary accessions: P19790 Q5JQI4 Q5SP17 Q9UQL9 Q9UQM0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005336.3

ENSEMBL proteins:

ENSP00000364803 ENSP00000364802

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Hsp70 + Hsc70, Hsp70)
	Human Recombinant Proteins from Abnova (HSPA1A)

OriGene Purified Recombinant Human Protein: HSPA1A

Antibodies for HSPA1A:

	Invitrogen Antibodies for HSPA1A
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for HSPA1A
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Hsp70 + Hsc70, Hsp70), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HSPA1A)
	Novus Biologicals Antibody for HSPA1A

Assays for HSPA1A:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P08107

ProtoNet protein and cluster: P08107

1 Blocks protein family: IPB001023 Heat shock protein Hsp70

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Similarity: Belongs to the heat shock protein 70 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005345

Applied Biosystems Silencer® siRNAs for HSPA1A

Sigma-Aldrich siRNA and siRNA Panels for HSPA1A

Sigma-Aldrich shRNA Panels and shRNA for HSPA1A

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005345
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005345
untagged cDNA clones in CMV expression vector (see all 2): NM_005345

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005345

UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107

Function: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against

aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as

within organelles. These chaperones participate in all these processes through their ability to

recognize nonnative conformations of other proteins. They bind extended peptide segments with a

net hydrophobic character exposed by polypeptides during translation and membrane translocation,

or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment

receptor for the virus to facilitate entry into the cell

Induction: By heat shock

Genatlas biochemistry entry for HSPA1A:

heat shock 70kDa protein A1,acting as a molecular chaperone

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hspa1a):

cellular

growth/size

homeostasis/metabolism

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for HSPA1A (Your Favorite Gene powered by Ingenuity)

Glucocorticoid Receptor Signaling
Huntington's Disease Signaling

GeneDecks HSPA1A for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HSPA1A

5/131 Interacting proteins for HSPA1A (P08107^{1, 2} ENSP00000364802³) via UniProtKB, MINT, and/or STRING (see all 131 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AIFM1	O95831², ENSP00000287295³	MINT-13840 MINT-13841 STRING (score=.898)
BAG1	Q99933², ENSP00000224112³	MINT-45860 MINT-45859 STRING (score=.818)
STUB1	Q9UNE7¹, ENSP00000219548³	EBI-629985, EBI-357085 STRING (score=.881)
MME	P08473¹	EBI-629985, EBI-353759
APAF1	O14727²	MINT-14029 MINT-14028

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HSPA1A
10/34 Novoseek chemical compound relationships for HSPA1A gene (see all 34 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
17-(allylamino)-17-demethoxygeldanamycin	61.64	1	17409432 (1)
oxygen	25.31	7	9176145 (1), 12215965 (1), 15544165 (1), 15633297 (1) (see all 6)
endotoxin	21.09	7	12444117 (1), 19405961 (1), 17947709 (1), 18323737 (1) (see all 5)
sodium orthovanadate	19.75	2	8914825 (1), 9141622 (1)
flavonoid	18.94	2	7636297 (1), 11471985 (1)
bapta	16.85	6	10718636 (2), 10544966 (2), 9806766 (1)
atp	14.18	31	11600431 (4), 12611892 (4), 12380681 (4), 8764325 (3) (see all 9)
urea	12.64	22	12397389 (6), 11729224 (5), 11125209 (3), 10651017 (3) (see all 6)
hoechst 33342	10.78	1	8914825 (1)
cdcl2	8.78	4	10403520 (4)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005345

Sigma-Aldrich siRNA and siRNA Panels for HSPA1A

Sigma-Aldrich shRNA Panels and shRNA for HSPA1A

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005345

REFSEQ mRNAs for HSPA1A gene:

NM_005345.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005345

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005345
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005345
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005345

Additional cDNA sequence: AK301243.1

24/101 DOTS entries (see all 101 ):

DT.309093 DT.100868791 DT.91787162 DT.102841835 DT.451040 DT.121331459 DT.100855495 DT.121331478

DT.121331306 DT.100695127 DT.121331286 DT.121331486 DT.100847810 DT.121331366 DT.100695123 DT.100676892

DT.100695139 DT.100695138 DT.121331336 DT.100057333 DT.121331372 DT.121331479 DT.75141405 DT.121331530

24/326 AceView cDNA sequences (see all 326 ):

BM790717 BQ718828 D57316 F03271 AK096017 F09929 AI815405 AW387720

BX388726 BQ362820 BM564625 CD514945 BQ640217 BQ717293 AA386402 AA382773

BF445743 BE305108 BX429885 AI671261 D54490 BI712613 CA776954 BF340013

highest scoring ESTs for HSPA1A:

BQ438750 AA102292 AA310944 AA324161 AA340718 AA381128 AA470127 AA496698 AA541788 AA553790

Unigene Clusters for HSPA1A:

Heat shock 70kDa protein 1A

Hs.274402 [show with all ESTs], Hs.702139 [show with all ESTs]

Unigene Representative Sequences: NM_005346, AK301243

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000375652 ENST00000375651

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HSPA1A expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HSPA1A

¹ / ² / ³

9 probe-sets matching HSPA1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90877_f_at²^{, 3}	U95-E	4	1.00	0.25	0.95	1.18	AI963715	0.40	0.20	0.32	2
1104_s_at²^{, 3}	U95-A	6	1.00	0.17	0.94	0.99	M11717	0.20	0.17	0.18	1
31692_at²^{, 3}	U95-A	6	1.00	0.17	0.97	0.83	M59830	0.20	0.17	0.18	1
200799_at²^{, 3}	U133-A	3	1.00	0.33	--	--	NM_005345	0.20	0.50	0.38	1
202581_at²^{, 3}	U133-A	4	1.00	0.25	--	--	NM_005346	0.20	0.17	0.18	2
200800_s_at²^{, 3}	U133-A	6	1.00	0.17	--	--	NM_005345	0.20	0.50	0.38	1
200799_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--
202581_at²	U133Plus2	4	1.00	0.25	--	--	--	--	--	--	--
200800_s_at²	U133Plus2	6	1.00	0.17	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.274402 Hs.702139
Expression variation in blood from EXPOLDB for HSPA1A
UniProtKB/Swiss-Prot: HSP71_HUMAN, P08107
Tissue specificity: HSPA1B is testis-specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HSPA1A gene from 5/15 species (see all 15 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	HSP70¹	--	heat shock protein 70	94.58(n) 98.28(a)	403612 NM_001003067.1 NP_001003067.1
cow (Bos taurus)	HSPA1A¹	--	heat shock 70kDa protein 1A	94.54(n) 98.6(a)	282254 NM_203322.2 NP_976067.2
rat (Rattus norvegicus)	Hspa1b¹	--	heat shock 70kD protein 1B (mapped)	92.36(n) 96.41(a)	294254 NM_212504.1 NP_997669.1
mouse (Mus musculus)	Hspa1a⁵ Hspa1b¹	17 (18.95 cM)⁵	heat shock protein 1A⁵ heat shock protein 1B¹	91.63(n)¹ 95.16(a)¹	15511¹ NM_010478.2¹ NP_034608.2¹ AK132331⁵ AK160912⁵ (see all 15)
zebrafish (Danio rerio)	hsp70²	--	heat shock cognate 70-kd protein	77.57(n)	30671 BC056709.1

About this table Species with no ortholog for HSPA1A

ENSEMBL Gene Tree for HSPA1A

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for HSPA1A gene

HSPA1B¹ HSPA7² HSPA1L² HSPA2² ENSG00000204388²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/13 NCBI SNPs in HSPA1A are shown (see all 13 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 41)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs17201185^1,2	C,F	31894171(+)	`ACACAA/CAAAAG`	1	--	ng3¹		6		MN NS	276
--	rs9348877^1,2	C,F	31894068(+)	`CAGGAG/AAATCG`	1	--	ng3¹		5		NS	180
--	rs41269733^1,2	F	31893799(+)	`TAAGGG/ACAGAT`	1	--	ng3¹		5		NS	180
--	rs41269729^1,2	F	31893659(+)	`TTTTTT/-AAGTT`	1	--	ut3¹		5		NS	180
--	rs506770^1,2	A,C	31893207(+)	`GAGGCC/GGACAA`	1	A/A	syn¹		7		MN NS	430
--	rs541340^1,2	C,F	31893222(-)	`TCCAGC/AACCTT`	1	V/V	syn¹		6		MN NS	252
	rs508633^1,2	C	31893432(+)	`GAGGTA/C/G/T GATTA`	3	V/V	syn¹		3		EA NA	60
--	rs508603^1,2	C	31893417(+)	`GGCCCA/C/G/T ACCAT`	3	P/P	syn¹ ese³		0	--	--	--	--
--	rs41269737^1,2	--	31894161(+)	`TCACAC/TACACA`	1	--	ng3¹		5		NS	182
--	rs35075242^1,2	--	31893297(+)	`ACAAG-/CAGGAA`	1	K/N	fra¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for HSPA1A (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 140550

10/65 Novoseek disease relationships for HSPA1A gene (see all 65 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	89.62	340	10718636 (4), 8189235 (4), 9880239 (4), 16572732 (3) (see all 99)
glioblastoma	43.71	10	9018110 (2), 7594817 (2), 9617483 (2), 7600522 (1) (see all 7)
myocardial hibernation	42.03	1	12445882 (1)
ischemia	38.26	35	7604425 (6), 8276180 (3), 8025704 (3), 9566609 (3) (see all 18)
cell damage	34.06	5	12930708 (1), 16036326 (1), 17036391 (1), 8892646 (1) (see all 5)
antidiuresis	32.40	1	11125209 (1)
necrosis	31.50	23	14523009 (2), 15735699 (1), 9395854 (1), 10958679 (1) (see all 20)
transient cerebral ischemia	22.93	2	10908039 (2)
melanoma b16	19.46	2	19157555 (2)
graves disease	18.74	1	1548334 (1)

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1 PharmGKB disease relationship for HSPA1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

About this table

Human Gene Mutation Database: HSPA1A
Genetic Association Database: HSPA1A
Human Genome Epidemiology Navigator: HSPA1A (43 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/547 PubMed articles for HSPA1A gene (see all 547 ):

The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. (PubMed id 15232679)^{1, 3, 6} Temple S.E....Waterer G.W. (2004)
Structure and expression of the three MHC-linked HSP70 genes. (PubMed id 1700760)^{1, 3, 4} Milner C.M. and Campbell R.D. (1990)
Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. (PubMed id 15963589)^{1, 3, 6} Pae C.U....Kim J.J. (2005)
Heat shock protein 70 and tumor necrosis factor alpha in Taiwanese patients with dementia. (PubMed id 15832029)^{1, 3, 6} Fung H.C....Lee-Chen G.J. (2005)
Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. (PubMed id 11779758)^{1, 3, 6} Vargas-Alarcon G....Burgos-Vargas R. (2002)
Is preeclampsia associated with higher frequency of HSP70 gene polymorphisms? (PubMed id 16202503)^{3, 6} Fekete A....Rigo J. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Phosphorylation and binding partner analysis of the TSC1-TSC2 complex. (PubMed id 15963462)^{3, 4} Nellist M....Luider T.M. (2005)
Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese population. (PubMed id 16333988)^{3, 6} Zhou F....Wu T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3303	HGNC: 5232	AceView: HSPA1AandHSPA1B	Ensembl:ENSG00000204389	euGenes: HUgn3303
ECgene: HSPA1A	H-InvDB: HSPA1A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for HSPA1A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hspa1a/

Licensable Technologies for HSPA1A
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HSPA1A:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HSPA1A-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HSPA1A		Antibodies for HSPA1A
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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Antibodies for HSPA1A

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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HSPA1A Gene at Home site.
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HSPA1A Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for HSPA1A

Summaries
for HSPA1A

Genomic Location
for HSPA1A

Proteins
for HSPA1A

Protein Domains/
Families
for HSPA1A

Gene Function
for HSPA1A

Pathways & Interactions
for HSPA1A

Drugs & Compounds
for HSPA1A

Transcripts
for HSPA1A

Expression
for HSPA1A

Orthologs
for HSPA1A

Paralogs
for HSPA1A

SNPs/Variants
for HSPA1A

Disorders & Mutations
for HSPA1A

Medical News
for HSPA1A

Publications
for HSPA1A

Search for HSPA1A

Genome Databases showing HSPA1A

Other Databases showing HSPA1A

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for HSPA1A

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for HSPA1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HSPA1A (Gene Symbol)
FLJ54303
FLJ54370
FLJ54392
FLJ54408
FLJ75127
HSP70-1
HSP70-1/HSP70-2
HSP70-1A
HSP70.1
HSP70I
HSP72
HSPA1
HSPA1B
OTTHUMP00000029287
dnaK-type molecular chaperone HSP70-1
heat shock 70kD protein 1A
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
heat shock-induced protein

HSPA1A Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor HSPA1A

Summariesfor HSPA1A

Genomic Locationfor HSPA1A

Proteinsfor HSPA1A

Protein Domains/Familiesfor HSPA1A

Gene Functionfor HSPA1A

Pathways & Interactionsfor HSPA1A

Drugs & Compoundsfor HSPA1A

Transcriptsfor HSPA1A

Expression for HSPA1A

Orthologsfor HSPA1A

Paralogsfor HSPA1A

SNPs/Variantsfor HSPA1A

Disorders & Mutationsfor HSPA1A

Medical Newsfor HSPA1A

Publicationsfor HSPA1A

Search for HSPA1A

Genome Databases showing HSPA1A

Other Databases showing HSPA1A

Specialized Databases showing HSPA1A

Licensable Technologiesfor HSPA1A

Servicesfor HSPA1A

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HSPA1A

Summaries
for HSPA1A

Genomic Location
for HSPA1A

Proteins
for HSPA1A

Protein Domains/
Families
for HSPA1A

Gene Function
for HSPA1A

Pathways & Interactions
for HSPA1A

Drugs & Compounds
for HSPA1A

Transcripts
for HSPA1A

Expression
for HSPA1A

Orthologs
for HSPA1A

Paralogs
for HSPA1A

SNPs/Variants
for HSPA1A

Disorders & Mutations
for HSPA1A

Medical News
for HSPA1A

Publications
for HSPA1A

Licensable Technologies
for HSPA1A

Services
for HSPA1A