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Aliases for HSPA14 Gene

Aliases for HSPA14 Gene

  • Heat Shock 70kDa Protein 14 2 3
  • Heat Shock Protein HSP60 3 4
  • HSP70-Like Protein 1 3 4
  • HSP70L1 3 4
  • Heat Shock 70kDa Protein 14 Isoform 1 Variant 3 3
  • Heat Shock Protein Hsp70-Related Protein 3
  • HSP70-4 3
  • HSP60 4

External Ids for HSPA14 Gene

Previous GeneCards Identifiers for HSPA14 Gene

  • GC10P014885
  • GC10P014920

Summaries for HSPA14 Gene

GeneCards Summary for HSPA14 Gene

HSPA14 (Heat Shock 70kDa Protein 14) is a Protein Coding gene. Diseases associated with HSPA14 include tetralogy of fallot. Among its related pathways are Cellular Senescence and Development_Glucocorticoid receptor signaling. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA14 Gene

  • Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Wiki entry for HSPA14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA14 Gene

Genomics for HSPA14 Gene

Regulatory Elements for HSPA14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA14 Gene

Chromosome:
10
Start:
14,838,160 bp from pter
End:
14,871,741 bp from pter
Size:
33,582 bases
Orientation:
Plus strand

Genomic View for HSPA14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA14 Gene

Proteins for HSPA14 Gene

  • Protein details for HSPA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDF9-HSP7E_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 14
    Protein Accession:
    Q0VDF9
    Secondary Accessions:
    • A8K8F8
    • B0YIY9
    • Q9P0X2
    • Q9UI07

    Protein attributes for HSPA14 Gene

    Size:
    509 amino acids
    Molecular mass:
    54794 Da
    Quaternary structure:
    • Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    Miscellaneous:
    • Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).

neXtProt entry for HSPA14 Gene

Proteomics data for HSPA14 Gene at MOPED

Post-translational modifications for HSPA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA14 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for HSPA14

No data available for DME Specific Peptides for HSPA14 Gene

Domains & Families for HSPA14 Gene

Gene Families for HSPA14 Gene

Protein Domains for HSPA14 Gene

Graphical View of Domain Structure for InterPro Entry

Q0VDF9

UniProtKB/Swiss-Prot:

HSP7E_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA14: view

Function for HSPA14 Gene

Molecular function for HSPA14 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Ontology (GO) - Molecular Function for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16002468
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA14: view
genes like me logo Genes that share phenotypes with HSPA14: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA14 Gene

Localization for HSPA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA14 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA14 Gene COMPARTMENTS Subcellular localization image for HSPA14 gene
Compartment Confidence
cytosol 5
mitochondrion 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16002468
GO:0005840 colocalizes_with ribosome IDA 16002468
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HSPA14: view

Pathways & Interactions for HSPA14 Gene

genes like me logo Genes that share pathways with HSPA14: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051083 de novo cotranslational protein folding TAS 16002468
genes like me logo Genes that share ontologies with HSPA14: view

No data available for SIGNOR curated interactions for HSPA14 Gene

Drugs & Compounds for HSPA14 Gene

(5) Drugs for HSPA14 Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nitric Oxide Approved Pharma 540
Potassium Experimental Pharma 0
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0
ATP Pharma Activator 0
serine Nutra 420

(6) Additional Compounds for HSPA14 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
glucose
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
retinoic acid
302-79-4
ribonucleic acid
genes like me logo Genes that share compounds with HSPA14: view

Transcripts for HSPA14 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSPA14 Gene

GeneLoc Exon Structure for
HSPA14
ECgene alternative splicing isoforms for
HSPA14

Expression for HSPA14 Gene

mRNA expression in normal human tissues for HSPA14 Gene

Protein differential expression in normal tissues from HIPED for HSPA14 Gene

This gene is overexpressed in Lymph node (14.4), Breast (9.4), Peripheral blood mononuclear cells (8.8), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA14 Gene



SOURCE GeneReport for Unigene cluster for HSPA14 Gene Hs.534169

genes like me logo Genes that share expression patterns with HSPA14: view

Protein tissue co-expression partners for HSPA14 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSPA14 Gene

Orthologs for HSPA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA14 35
  • 90.83 (n)
  • 92.14 (a)
HSPA14 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA14 35
  • 92.34 (n)
  • 95.09 (a)
HSPA14 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa14 35
  • 85.85 (n)
  • 90.96 (a)
Hspa14 16
Hspa14 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA14 35
  • 99.54 (n)
  • 99.02 (a)
HSPA14 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa14 35
  • 84.15 (n)
  • 90.37 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA14 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves HSPA14 35
  • 77.71 (n)
  • 82.94 (a)
HSPA14 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA14 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa14 35
  • 73.48 (n)
  • 76.79 (a)
Str.10057 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12197 35
zebrafish
(Danio rerio)
Actinopterygii hspa14 35
  • 67.33 (n)
  • 71.2 (a)
hspa14 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9232 35
fruit fly
(Drosophila melanogaster)
Insecta CG7182 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11F1.1 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
ManyToMany
Species with no ortholog for HSPA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA14 Gene

ENSEMBL:
Gene Tree for HSPA14 (if available)
TreeFam:
Gene Tree for HSPA14 (if available)

Paralogs for HSPA14 Gene

Paralogs for HSPA14 Gene

genes like me logo Genes that share paralogs with HSPA14: view

Variants for HSPA14 Gene

Sequence variations from dbSNP and Humsavar for HSPA14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs114406410 -- 14,858,099(+) TTCAT(C/T)TCCTG intron-variant
rs114463445 -- 14,846,806(+) TTGAC(C/T)GTAAG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs114492585 -- 14,854,190(+) TGAAG(C/T)AGCGA missense, reference
rs114567090 -- 14,850,929(+) TTTTT(C/T)TTTAA intron-variant
rs114573476 -- 14,848,568(+) ATACT(A/G)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA14 Gene

Variant ID Type Subtype PubMed ID
nsv523583 CNV Gain 19592680
nsv469720 CNV Complex 16826518
nsv831793 CNV Loss 17160897

Variation tolerance for HSPA14 Gene

Residual Variation Intolerance Score: 18.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA14 Gene

HapMap Linkage Disequilibrium report
HSPA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA14 Gene

Disorders for HSPA14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSPA14 Gene - From: GeneCards

Disorder Aliases PubMed IDs
tetralogy of fallot
  • tetrology of fallot
- elite association

Relevant External Links for HSPA14

Genetic Association Database (GAD)
HSPA14
Human Genome Epidemiology (HuGE) Navigator
HSPA14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA14
genes like me logo Genes that share disorders with HSPA14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSPA14 Gene

Publications for HSPA14 Gene

  1. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. (PMID: 19372565) Lundgren K. … Burrows F.J. (Mol. Cancer Ther. 2009) 23 67
  2. [Regulation of human dendrite cells' physiological functions with the recombinant heat shock protein Hsp70]. (PMID: 19957893) Pal'tsev M.A. … Moskaleva E.I.u. (Ross Fiziol Zh Im I M Sechenova 2009) 23 67
  3. [Second anoxia-reoxygenation does not cause the apoptotic cell death of cultured neonatal cardiomyocytes]. (PMID: 19441711) Surova O.V. … MoA-benko O.O. (Fiziol Zh 2009) 23 67
  4. Monocytes and vascular endothelial cells apoptosis. Role of p-HSP27. (PMID: 20065497) Gawad A. … Pawlik W.W. (J. Physiol. Pharmacol. 2009) 23 67
  5. Excretory/secretory proteome of the adult developmental stage of human blood fluke, Schistosoma japonicum. (PMID: 19299421) Liu F. … Han Z.G. (Mol. Cell Proteomics 2009) 23 67

Products for HSPA14 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSPA14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA14
    • Block miRNA regulation of HSPA14 using miScript Target Protectors

    Sources for HSPA14 Gene

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