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HSPA14 Gene

protein-coding   GIFtS: 59
GCID: GC10P014790

Heat Shock 70kDa Protein 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock 70kDa Protein 141 2     Heat Shock 70 KDa Protein 142
HSP70L12 3 5     Heat Shock 70kDa Protein 14 Isoform 1 Variant 32
Heat Shock Protein HSP602 3     Heat Shock Protein Hsp70-Related Protein2
HSP70-Like Protein 12 3     HSP603
HSP70-42     

External Ids:    HGNC: 295261   Entrez Gene: 511822   Ensembl: ENSG000001875227   OMIM: 6103695   UniProtKB: Q0VDF93   

Export aliases for HSPA14 gene to outside databases

Previous GC identifers: GC10P014885 GC10P014920


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSPA14 Gene:
HSPA14 (heat shock 70kDa protein 14) is a protein-coding gene. Diseases associated with HSPA14 include anoxia, and plasmodium falciparum malaria. An important paralog of this gene is HSPA8.

UniProtKB/Swiss-Prot: HSP7E_HUMAN, Q0VDF9
Function: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent
polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while
DNAJC2 stimulates its ATPase activity

Gene Wiki entry for HSPA14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSPA14 gene promoter:
         p53   ATF-2   HSF1 (long)   POU6F1 (c2)   MEF-2A   CRE-BP1   PPAR-gamma1   HSF1short   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSPA14 promoter sequence
   Search Chromatin IP Primers for HSPA14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSPA14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

HSPA14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA14 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P014790:  view genomic region     (about GC identifiers)

Start:
14,880,163 bp from pter      End:
14,913,740 bp from pter
Size:
33,578 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HSP7E_HUMAN, Q0VDF9 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 14  
Size: 509 amino acids; 54794 Da
Subunit: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone
HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2
Miscellaneous: Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating
efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate
vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947).
May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers
(PubMed:15930317)
Secondary accessions: A8K8F8 B0YIY9 Q9P0X2 Q9UI07

Explore the universe of human proteins at neXtProt for HSPA14: NX_Q0VDF9

Explore proteomics data for HSPA14 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSPA14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265134.1  NP_057383.2  

    ENSEMBL proteins: 
     ENSP00000367623   ENSP00000390513   ENSP00000404691  

    HSPA14 Human Recombinant Protein Products:

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    OriGene Purified Protein for HSPA14
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    OriGene MassSpec for HSPA14
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    Novus Biologicals HSPA14 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSPA14
    Cloud-Clone Corp. Proteins for HSPA14

    HSPA14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for HSPA14
    Cloud-Clone Corp. Antibodies for HSPA14
    ThermoFisher Antibodies for HSPA14
    LSBio Antibodies in human, mouse, rat for HSPA14

    HSPA14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HSPA14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSPA14
    Cloud-Clone Corp. CLIAs for HSPA14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry Q0VDF9

    ProtoNet protein and cluster: Q0VDF9

    1 Blocks protein domain: IPB001023 Heat shock protein Hsp70

    UniProtKB/Swiss-Prot: HSP7E_HUMAN, Q0VDF9
    Similarity: Belongs to the heat shock protein 70 family


    HSPA14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSP7E_HUMAN, Q0VDF9
    Function: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent
    polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while
    DNAJC2 stimulates its ATPase activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16002468
    GO:0005524ATP binding IEA--
         
    HSPA14 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA14:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSPA14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSPA14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSPA14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSPA14

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSPA14:
    hsa-mir-222-3p (MIRT046763), hsa-mir-373-3p (MIRT002543), hsa-mir-100-5p (MIRT048464)

    Block miRNA regulation of human, mouse, rat HSPA14 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSPA14
    SwitchGear 3'UTR luciferase reporter plasmidHSPA14 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSPA14
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA14

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for HSPA14 (see all 6)
    OriGene ORF clones in mouse, rat for HSPA14
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    GenScript: all cDNA clones in your preferred vector: HSPA14 (NM_016299)
    Sino Biological Human cDNA Clone for HSPA14
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA14

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSPA14 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSP7E_HUMAN, Q0VDF9: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular2
    mitochondrion2
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16002468
    GO:0005840colocalizes with ribosome IDA16002468

    HSPA14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSPA14 About    
    See pathways by source

    SuperPathContained pathways About
    1Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    2Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37
    3Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Proteolysis Putative ubiquitin pathway
    Proteolysis Putative ubiquitin pathway
    5Development Glucocorticoid receptor signaling
    Development Glucocorticoid receptor signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HSPA14 (see all 6)
        Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    CFTR folding and maturation (norm and CF)
    Proteolysis Putative ubiquitin pathway

    1 BioSystems Pathway for HSPA14
        Parkin-Ubiquitin Proteasomal System pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including HSPA14: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HSPA14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSPA14 (Q0VDF93 ENSP000003676234) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJC2Q995433, ENSP000003685654I2D: score=1 STRING: ENSP00000368565
    STIP1P319483, ENSP000003059584I2D: score=2 STRING: ENSP00000305958
    DDA1Q9BW613I2D: score=1 
    TLR4O002063I2D: score=1 
    CLPBENSP000002940534STRING: ENSP00000294053
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0006950response to stress ----
    GO:0051083'de novo' cotranslational protein folding TAS16002468

    HSPA14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSPA14 (HSP7E)

    10 Novoseek inferred chemical compound relationships for HSPA14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arsenite 21.2 1 11678611 (1)
    ribonucleic acid 16.6 1 9141521 (1)
    atp 7.77 1 14699958 (1)
    steroid 5.82 4 8625242 (1), 9824379 (1), 7714077 (1)
    oxygen 0 1 10343137 (1)
    nitric oxide 0 1 8706913 (1)
    glucose 0 1 11099777 (1)
    potassium 0 1 8679653 (1)
    serine 0 1 1708512 (1)
    retinoic acid 0 1 11678611 (1)



    HSPA14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSPA14 gene (3 alternative transcripts): 
    NM_001037538.1  NM_001278205.1  NM_016299.3  

    Unigene Cluster for HSPA14:

    Heat shock 70kDa protein 14
    Hs.534169  [show with all ESTs]
    Unigene Representative Sequence: AK226065
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378372(uc010qbw.2 uc001inf.3) ENST00000493863 ENST00000437161(uc001ine.3)
    ENST00000493178 ENST00000441647 ENST00000470430
    miRNA
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    Block miRNA regulation of human, mouse, rat HSPA14 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSPA14
    SwitchGear 3'UTR luciferase reporter plasmidHSPA14 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSPA14
    Predesigned siRNA for gene silencing in human, mouse, rat HSPA14
    Clone
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    OriGene clones in human, mouse for HSPA14 (see all 6)
    OriGene ORF clones in mouse, rat for HSPA14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSPA14 (NM_016299)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSPA14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSPA14
    Primer
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    OriGene qPCR primer pairs and template standards for HSPA14
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA14
      QuantiTect SYBR Green Assays in human, mouse, rat HSPA14
      QuantiFast Probe-based Assays in human, mouse, rat HSPA14

    Additional mRNA sequence: 

    AF112210.1 AF143723.1 AK000880.1 AK225265.1 AK225651.1 AK226065.1 AK292323.1 AK302452.1 
    BC026226.1 BC038845.1 BC065281.1 BC108738.1 BC119690.1 BC119691.1 

    9 DOTS entries:

    DT.101326  DT.445741  DT.40112535  DT.91853987  DT.86840710  DT.101968507  DT.40131920  DT.40215847 
    DT.430691 

    Selected AceView cDNA sequences (see all 248):

    CR610820 AA417742 BQ008496 BM765434 AW468483 AW016387 AI675179 BC015696 
    AI130765 AK000880 AI023969 AI417376 BQ185962 CF593935 AI042411 AA731254 
    CR601479 AA453814 BM727282 N48644 CA448435 CR590065 CA436980 BX471742 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSPA14 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^
    SP1:                                                                                                              -           -                                 
    SP2:                                            -     -           -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                            -     -     -     -     -     -     -     -                                                                     

    ExUns: 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for HSPA14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSPA14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGATCAA
    HSPA14 Expression
    About this image

    HSPA14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSPA14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534169
        Pathway & Disease-focused RT2 Profiler PCR Array including HSPA14: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSPA14
    OriGene qSTAR qPCR primer pairs in human, mouse for HSPA14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSPA14
    QuantiTect SYBR Green Assays in human, mouse, rat HSPA14
    QuantiFast Probe-based Assays in human, mouse, rat HSPA14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSPA14 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa141 , 5 heat shock protein 141, 5 85.85(n)1
    90.96(a)1
      2 (1.97 cM)5
    504971  NM_015765.21  NP_056580.21 
     34888505 
    chicken
    (Gallus gallus)
    Aves HSPA141 heat shock 70kDa protein 14 77.71(n)
    82.94(a)
      418802  XM_416996.4  XP_416996.3 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA146
    heat shock 70kDa protein 14
    81(a)
    1 ↔ 1
    GL343559.1(230975-247221)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121972 Xenopus laevis transcribed sequence with moderate similarity more 77.5(n)    BX854226.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hspa141 heat shock protein 14 67.33(n)
    71.2(a)
      565232  NM_001045076.1  NP_001038541.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71826
    --
    26(a)
    1 ↔ 1
    3L(8337521-8339306)
    worm
    (Caenorhabditis elegans)
    Secernentea F11F1.16
    Protein F11F1.1, isoform b
    25(a)
    1 ↔ 1
    III(13395706-13400606) WBGene00008714
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSA26
    ATP binding protein involved in protein folding an...
    26(a)
    1 → many
    XII(95566-97485) YLL024C


    ENSEMBL Gene Tree for HSPA14 (if available)
    TreeFam Gene Tree for HSPA14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HSPA14 gene
    HSPA82  HSPA92  HSPA52  HSPA1L2  HSPA1B2  HSPA62  HSPA22  HSPA1A2  
    14 SIMAP similar genes for HSPA14 using alignment to 6 protein entries:     HSP7E_HUMAN (see all proteins):
    HSPA8    HSPA9    HSPA1A    HSPA1B    HSPA1L    HSPA2
    HSPA5    HSPA6    HSPA7    HSPH1    HSPA4    HS24/p52
    HSPA4L    HYOU1

    HSPA14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSPA14 (see all 609)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363474
    A breast cancer sample4--see VAR_0363472 A V mis40--------
    rs577340271,2
    C,F--14882040(+) ATTGTT/AATATA 3 -- int11Minor allele frequency- A:0.50WA 2
    rs1402432511,2
    C--14882041(+) TTGTA-/ATATATA 3 -- int10--------
    rs38305991,2
    C,F--14882061(-) AAAAAA/-TAATA 3 -- int13Minor allele frequency- -:0.50NA 6
    rs780445031,2
    F--14882306(+) AGGCAG/ATGTCT 3 -- int11Minor allele frequency- A:0.14WA 118
    rs1424362061,2
    --14882324(+) CTTAGC/TGTTGG 3 -- int10--------
    rs109067721,2
    C,F,H--14882340(+) CTCTGA/TTATGG 3 -- int116Minor allele frequency- T:0.05NA NS EA 1110
    rs1513308341,2
    C--14882392(+) GTAATC/TTGCGT 3 -- int10--------
    rs1170857321,2
    C,F--14882630(+) AGTAAC/AAGCTA 3 -- int11Minor allele frequency- A:0.03EA 120
    rs1846456841,2
    C--14882642(+) ATTAAC/TGTCTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for HSPA14 (14880163 - 14913740 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HSPA14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831793CNV Loss17160897
    nsv523583CNV Gain19592680
    nsv469720CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSPA14
    DNA2.0 Custom Variant and Variant Library Synthesis for HSPA14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610369    OMIM disorders: --

    Selected diseases for HSPA14 (see all 27):    
    About MalaCards
    anoxia    plasmodium falciparum malaria    tetralogy of fallot    endometrial carcinoma
    cryptorchidism    sudden infant death syndrome    malaria    fibrosarcoma
    ischemia    multiple myeloma    laryngitis    infertility
    myeloma    breast and colorectal cancer    hypoxia    cerebritis
    arthritis    retinitis    breast cancer    rheumatoid arthritis


    HSPA14 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for HSPA14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 81.1 110 2296591 (2), 18261988 (2), 8625242 (2), 18418731 (2) (see all 94)
    endometrial carcinoma 13.9 3 9824379 (2), 8625242 (1)
    tumors 3.58 6 17911639 (1), 7860144 (1), 11678611 (1), 19372565 (1) (see all 5)
    ischemia 1.76 2 9302090 (1), 10571093 (1)
    leukemia 0 1 15832946 (1)
    necrosis 0 2 7860144 (1), 1889817 (1)
    reflux 0 1 16466100 (1)
    breast cancer 0 1 8455204 (1)
    rheumatoid arthritis 0 1 17343252 (1)

    Genetic Association Database (GAD): HSPA14
    Human Genome Epidemiology (HuGE) Navigator: HSPA14 (5 documents)

    Export disorders for HSPA14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSPA14 gene, integrated from 10 sources (see all 148):
    (articles sorted by number of sources associating them with HSPA14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    2. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PubMed id 19527514)1, 4 Menon R....Thorsen P. (amp 2009)
    3. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    4. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PubMed id 18818748)1, 4 Velez D.R....Menon R. (PLoS ONE 2008)
    5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    6. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome- associated complex. (PubMed id 16002468)1, 2 Otto H.... Rospert S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. (PubMed id 14592822)1, 2 Wan T.... Cao X. (Blood 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51182 HGNC: 29526 AceView: HSPA14 Ensembl:ENSG00000187522 euGenes: HUgn51182
    ECgene: HSPA14 H-InvDB: HSPA14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSPA14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSPA14 gene:
    Search GeneIP for patents involving HSPA14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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