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Aliases for HSPA14 Gene

Aliases for HSPA14 Gene

  • Heat Shock 70kDa Protein 14 2 3
  • HSP70L1 3 4 6
  • Heat Shock Protein HSP60 3 4
  • HSP70-Like Protein 1 3 4
  • Heat Shock 70kDa Protein 14 Isoform 1 Variant 3 3
  • Heat Shock Protein Hsp70-Related Protein 3
  • Heat Shock 70 KDa Protein 14 3
  • HSP70-4 3
  • HSP60 4

External Ids for HSPA14 Gene

Summaries for HSPA14 Gene

GeneCards Summary for HSPA14 Gene

HSPA14 (Heat Shock 70kDa Protein 14) is a Protein Coding gene. Diseases associated with HSPA14 include malaria and tetralogy of fallot. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) and Development_Glucocorticoid receptor signaling. An important paralog of this gene is HSPA2.

UniProtKB/Swiss-Prot for HSPA14 Gene

  • Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Wiki entry for HSPA14 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA14 Gene

Genomics for HSPA14 Gene

Genomic Location for HSPA14 Gene

Start:
14,838,160 bp from pter
End:
14,871,741 bp from pter
Size:
33,582 bases
Orientation:
Plus strand

Genomic View for HSPA14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA14 Gene

Regulatory Elements for HSPA14 Gene

Proteins for HSPA14 Gene

  • Protein details for HSPA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDF9-HSP7E_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 14
    Protein Accession:
    Q0VDF9
    Secondary Accessions:
    • A8K8F8
    • B0YIY9
    • Q9P0X2
    • Q9UI07

    Protein attributes for HSPA14 Gene

    Size:
    509 amino acids
    Molecular mass:
    54794 Da
    Quaternary structure:
    • Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    Miscellaneous:
    • Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).

neXtProt entry for HSPA14 Gene

Proteomics data for HSPA14 Gene at MOPED

Post-translational modifications for HSPA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA14 Gene

No data available for DME Specific Peptides for HSPA14 Gene

Domains for HSPA14 Gene

Gene Families for HSPA14 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA14 Gene

UniProtKB/Swiss-Prot:

HSP7E_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • Q0VDF9
genes like me logo Genes that share domains with HSPA14: view

Function for HSPA14 Gene

Molecular function for HSPA14 Gene

UniProtKB/Swiss-Prot Function: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Ontology (GO) - Molecular Function for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16002468
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA14: view

Phenotypes for HSPA14 Gene

GenomeRNAi human phenotypes for HSPA14:
genes like me logo Genes that share phenotypes with HSPA14: view

miRNA for HSPA14 Gene

miRTarBase miRNAs that target HSPA14

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA14 Gene

Localization for HSPA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA14 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA14 Gene COMPARTMENTS Subcellular localization image for HSPA14 gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16002468
GO:0005840 colocalizes_with ribosome IDA 16002468
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HSPA14: view

Pathways for HSPA14 Gene

genes like me logo Genes that share pathways with HSPA14: view

Gene Ontology (GO) - Biological Process for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0006950 response to stress --
GO:0051083 de novo cotranslational protein folding TAS 16002468
genes like me logo Genes that share ontologies with HSPA14: view

Compounds for HSPA14 Gene

(10) Novoseek inferred chemical compound relationships for HSPA14 Gene

Compound -log(P) Hits PubMed IDs
arsenite 21.2 1
ribonucleic acid 16.6 1
atp 7.77 1
steroid 5.82 3
oxygen 0 1
genes like me logo Genes that share compounds with HSPA14: view

Transcripts for HSPA14 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSPA14 Gene

GeneLoc Exon Structure for
HSPA14
ECgene alternative splicing isoforms for
HSPA14

Expression for HSPA14 Gene

mRNA expression in normal human tissues for HSPA14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA14 Gene

SOURCE GeneReport for Unigene cluster for HSPA14 Gene Hs.534169

genes like me logo Genes that share expressions with HSPA14: view

Orthologs for HSPA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA14 36
  • 99.54 (n)
  • 99.02 (a)
HSPA14 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA14 36
  • 90.83 (n)
  • 92.14 (a)
HSPA14 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA14 36
  • 92.34 (n)
  • 95.09 (a)
HSPA14 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa14 36
  • 85.85 (n)
  • 90.96 (a)
Hspa14 16
Hspa14 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA14 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 82 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hspa14 36
  • 84.15 (n)
  • 90.37 (a)
chicken
(Gallus gallus)
Aves HSPA14 36
  • 77.71 (n)
  • 82.94 (a)
HSPA14 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA14 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12197 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa14 36
  • 73.48 (n)
  • 76.79 (a)
Str.10057 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9232 36
zebrafish
(Danio rerio)
Actinopterygii hspa14 36
  • 67.33 (n)
  • 71.2 (a)
hspa14 37
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7182 37
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11F1.1 37
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 37
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
ManyToMany
Species with no ortholog for HSPA14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA14 Gene

ENSEMBL:
Gene Tree for HSPA14 (if available)
TreeFam:
Gene Tree for HSPA14 (if available)

Paralogs for HSPA14 Gene

Paralogs for HSPA14 Gene

genes like me logo Genes that share paralogs with HSPA14: view

Variants for HSPA14 Gene

Sequence variations from dbSNP and Humsavar for HSPA14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1869222 -- 14,860,695(-) CTAGT(C/T)TCCTT intron-variant
rs2272147 -- 14,849,582(+) GAAAA(C/T)TGACA intron-variant
rs2400104 -- 14,850,033(+) ACTGA(C/G)GGGGG intron-variant
rs3210848 -- 14,846,382(+) TAATA(C/T)TTGGA utr-variant-3-prime, intron-variant, nc-transcript-variant
rs3830599 -- 14,840,062(-) AAAAA(-/A)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA14 Gene

Variant ID Type Subtype PubMed ID
nsv523583 CNV Gain 19592680
nsv469720 CNV Complex 16826518
nsv831793 CNV Loss 17160897

Relevant External Links for HSPA14 Gene

HapMap Linkage Disequilibrium report
HSPA14

Disorders for HSPA14 Gene

(2) MalaCards Diseases for HSPA14 Gene

Search for HSPA14 Gene in MalaCards »

(9) Novoseek inferred disease relationships for HSPA14 Gene

Disease -log(P) Hits PubMed IDs
shock 81.1 105
endometrial carcinoma 13.9 3
tumors 3.58 5
ischemia 1.76 2
leukemia 0 1

Relevant External Links for HSPA14

Genetic Association Database (GAD)
HSPA14
Human Genome Epidemiology (HuGE) Navigator
HSPA14
genes like me logo Genes that share disorders with HSPA14: view

No data available for UniProtKB/Swiss-Prot for HSPA14 Gene

Publications for HSPA14 Gene

  1. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X. … Bell D.A. (PLoS ONE 2010) 3 49
  2. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. (PMID: 14592822) Wan T. … Cao X. (Blood 2004) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome- associated complex. (PMID: 16002468) Otto H. … Rospert S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for HSPA14 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSPA14
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA14
    • Block miRNA regulation of HSPA14 using miScript Target Protectors

    Sources for HSPA14 Gene

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