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Aliases for HSPA14 Gene

Aliases for HSPA14 Gene

  • Heat Shock Protein Family A (Hsp70) Member 14 2 3 5
  • Heat Shock Protein HSP60 3 4
  • HSP70-Like Protein 1 3 4
  • HSP70L1 3 4
  • Heat Shock 70kDa Protein 14 Isoform 1 Variant 3 3
  • Heat Shock Protein Hsp70-Related Protein 3
  • Heat Shock 70 KDa Protein 14 3
  • Heat Shock 70kDa Protein 14 2
  • HSP70-4 3
  • HSP60 4

External Ids for HSPA14 Gene

Previous GeneCards Identifiers for HSPA14 Gene

  • GC10P014885
  • GC10P014920

Summaries for HSPA14 Gene

GeneCards Summary for HSPA14 Gene

HSPA14 (Heat Shock Protein Family A (Hsp70) Member 14) is a Protein Coding gene. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF).

UniProtKB/Swiss-Prot for HSPA14 Gene

  • Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Wiki entry for HSPA14 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA14 Gene

Genomics for HSPA14 Gene

Regulatory Elements for HSPA14 Gene

Enhancers for HSPA14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G015344 1.6 FANTOM5 Ensembl ENCODE 31.3 +507.7 507700 3.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SP5 ZHX2 REST MIER3 SMARCA4 HSPA14 FAM171A1 NMT2 LOC105376434
GH10G014558 2 FANTOM5 Ensembl ENCODE dbSUPER 21.1 -271.6 -271624 16.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 CBX5 HSPA14 PRPF18 CDNF LOC105376429 ENSG00000273474 ENSG00000272853 FAM107B DCLRE1C GC10M014524
GH10G014875 1.1 ENCODE 21.1 +40.0 39984 5.0 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 HSPA14 CDNF DCLRE1C ENSG00000272853 LOC100421372
GH10G014498 1 Ensembl ENCODE 21.6 -339.1 -339061 1.0 CTCF ARID4B ZIC2 RAD21 GTF3C2 ZBTB48 SCRT2 ZNF207 SMC3 RCOR1 HSPA14 PRPF18 CDNF DCLRE1CP1 ACBD7 GAPDHP45 GC10M014524 FRMD4A
GH10G014582 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -251.6 -251592 8.0 PKNOX1 FOXA2 WRNIP1 SIN3A YY1 ETS1 ZNF121 GATA2 FOS SP5 HSPA14 CDNF FAM107B GC10M014524 LOC105376429
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSPA14 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000024876 340 2201 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207

Genomic Location for HSPA14 Gene

Chromosome:
10
Start:
14,838,160 bp from pter
End:
14,871,741 bp from pter
Size:
33,582 bases
Orientation:
Plus strand

Genomic View for HSPA14 Gene

Genes around HSPA14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA14 Gene

Proteins for HSPA14 Gene

  • Protein details for HSPA14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VDF9-HSP7E_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 14
    Protein Accession:
    Q0VDF9
    Secondary Accessions:
    • A8K8F8
    • B0YIY9
    • Q9P0X2
    • Q9UI07

    Protein attributes for HSPA14 Gene

    Size:
    509 amino acids
    Molecular mass:
    54794 Da
    Quaternary structure:
    • Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
    Miscellaneous:
    • Acts as a potent immunoadjuvant, capable to interact with antigen-presenting cells and generating efficient CD8(+) T-cell responses. May be used as adjuvant to enhance effect of vaccine G1F/M2, a candidate vaccine against respiratory syncytial virus (RSV), a major respiratory pathogen in newborns (PubMed:18851947). May also be used as adjuvant to prepare antigenic fusion protein for the therapeutics of cancers (PubMed:15930317).

neXtProt entry for HSPA14 Gene

Post-translational modifications for HSPA14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA14 Gene

No data available for DME Specific Peptides for HSPA14 Gene

Domains & Families for HSPA14 Gene

Gene Families for HSPA14 Gene

Protein Domains for HSPA14 Gene

Graphical View of Domain Structure for InterPro Entry

Q0VDF9

UniProtKB/Swiss-Prot:

HSP7E_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA14: view

Function for HSPA14 Gene

Molecular function for HSPA14 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.

Gene Ontology (GO) - Molecular Function for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16002468
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA14: view
genes like me logo Genes that share phenotypes with HSPA14: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA14 Gene

Localization for HSPA14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA14 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA14 gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 16002468
GO:0005840 colocalizes_with ribosome IDA 16002468
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HSPA14: view

Pathways & Interactions for HSPA14 Gene

genes like me logo Genes that share pathways with HSPA14: view

Gene Ontology (GO) - Biological Process for HSPA14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051083 de novo cotranslational protein folding TAS 16002468
genes like me logo Genes that share ontologies with HSPA14: view

No data available for SIGNOR curated interactions for HSPA14 Gene

Drugs & Compounds for HSPA14 Gene

(7) Drugs for HSPA14 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Elesclomol (STA-4783) Pharma Oxidative stress/apoptosis inducer,potent and novel 0

(4) Additional Compounds for HSPA14 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for HSPA14 Gene

Compound Action Cas Number
Elesclomol (STA-4783) Oxidative stress/apoptosis inducer,potent and novel 488832-69-5
genes like me logo Genes that share compounds with HSPA14: view

Drug Products

Transcripts for HSPA14 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^
SP1: - -
SP2: - - -
SP3:
SP4:
SP5: - - - - - - - -
SP6: - -
SP7: - - - - - -
SP8: - - -
SP9: -
SP10:
SP11:
SP12: -

ExUns: 15 ^ 16 ^ 17a · 17b ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSPA14 Gene

GeneLoc Exon Structure for
HSPA14
ECgene alternative splicing isoforms for
HSPA14

Expression for HSPA14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA14 Gene

Protein differential expression in normal tissues from HIPED for HSPA14 Gene

This gene is overexpressed in Lymph node (14.4), Breast (9.4), Peripheral blood mononuclear cells (8.8), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA14 Gene



Protein tissue co-expression partners for HSPA14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA14 Gene:

HSPA14

SOURCE GeneReport for Unigene cluster for HSPA14 Gene:

Hs.534169

Evidence on tissue expression from TISSUES for HSPA14 Gene

  • Adrenal gland(4.2)
  • Liver(4.2)
  • Nervous system(4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with HSPA14: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA14 Gene

Orthologs for HSPA14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA14 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia HSPA14 34 35
  • 92.34 (n)
cow
(Bos Taurus)
Mammalia HSPA14 34 35
  • 90.83 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA14 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa14 34 16 35
  • 85.85 (n)
rat
(Rattus norvegicus)
Mammalia Hspa14 34
  • 84.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves HSPA14 34 35
  • 77.71 (n)
lizard
(Anolis carolinensis)
Reptilia HSPA14 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa14 34
  • 73.48 (n)
Str.10057 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12197 34
zebrafish
(Danio rerio)
Actinopterygii hspa14 34 35
  • 67.33 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9232 34
fruit fly
(Drosophila melanogaster)
Insecta CG7182 35
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F11F1.1 35
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSA2 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
ManyToMany
Species where no ortholog for HSPA14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA14 Gene

ENSEMBL:
Gene Tree for HSPA14 (if available)
TreeFam:
Gene Tree for HSPA14 (if available)

Paralogs for HSPA14 Gene

genes like me logo Genes that share paralogs with HSPA14: view

No data available for Paralogs for HSPA14 Gene

Variants for HSPA14 Gene

Sequence variations from dbSNP and Humsavar for HSPA14 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs374837716 A breast cancer sample 14,848,641(+) CATCG(C/T)GGAAA reference, missense
rs1000088516 -- 14,861,966(+) GAGAT(C/G)ACGCC intron-variant
rs1000177458 -- 14,843,139(+) AGTGG(G/T)TTGGA intron-variant
rs1000193734 -- 14,867,630(+) CCTAG(C/T)GTCCT intron-variant
rs1000309553 -- 14,837,637(+) ACAAC(A/G)TGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSPA14 Gene

Variant ID Type Subtype PubMed ID
nsv1043133 CNV loss 25217958
nsv469720 CNV gain 16826518
nsv523583 CNV gain 19592680
nsv831793 CNV loss 17160897

Variation tolerance for HSPA14 Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA14 Gene

Disorders for HSPA14 Gene

Relevant External Links for HSPA14

Genetic Association Database (GAD)
HSPA14
Human Genome Epidemiology (HuGE) Navigator
HSPA14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA14

No disorders were found for HSPA14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA14 Gene

Publications for HSPA14 Gene

  1. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X. … Bell D.A. (PLoS ONE 2010) 3 46 64
  2. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PMID: 19019335) Velez D.R. … Menon R. (Am. J. Obstet. Gynecol. 2009) 3 46 64
  3. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. (PMID: 19527514) Menon R. … Thorsen P. (Reprod. Biol. Endocrinol. 2009) 3 46 64
  4. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. (PMID: 18818748) Velez D.R. … Menon R. (PLoS ONE 2008) 3 46 64
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64

Products for HSPA14 Gene

Sources for HSPA14 Gene

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