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Aliases for HSPA13 Gene

Aliases for HSPA13 Gene

  • Heat Shock Protein 70kDa Family, Member 13 2 3
  • STCH 3 4 6
  • Stress-70 Protein Chaperone Microsome-Associated 60 KDa Protein 3 4
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kDa 2 3
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kD 2 3
  • Microsomal Stress-70 Protein ATPase Core 3 4
  • Microsomal Stress 70 Protein ATPase Core 3
  • Heat Shock 70 KDa Protein 13 3

External Ids for HSPA13 Gene

Previous HGNC Symbols for HSPA13 Gene

  • STCH

Previous GeneCards Identifiers for HSPA13 Gene

  • GC21M014666
  • GC21M015743
  • GC21M001113

Summaries for HSPA13 Gene

Entrez Gene Summary for HSPA13 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA13 Gene

HSPA13 (Heat Shock Protein 70kDa Family, Member 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HSPA13 Gene

  • Has peptide-independent ATPase activity

Gene Wiki entry for HSPA13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA13 Gene

Genomics for HSPA13 Gene

Regulatory Elements for HSPA13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA13 Gene

Start:
14,371,115 bp from pter
End:
14,383,484 bp from pter
Size:
12,370 bases
Orientation:
Minus strand

Genomic View for HSPA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA13 Gene

Proteins for HSPA13 Gene

  • Protein details for HSPA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48723-HSP13_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 13
    Protein Accession:
    P48723
    Secondary Accessions:
    • B2R616
    • Q8NE40

    Protein attributes for HSPA13 Gene

    Size:
    471 amino acids
    Molecular mass:
    51927 Da
    Quaternary structure:
    • Binds UBQLN2

neXtProt entry for HSPA13 Gene

Proteomics data for HSPA13 Gene at MOPED

Post-translational modifications for HSPA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA13 Gene

Domains for HSPA13 Gene

Gene Families for HSPA13 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA13 Gene

Graphical View of Domain Structure for InterPro Entry

P48723

UniProtKB/Swiss-Prot:

HSP13_HUMAN :
  • P48723
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA13: view

Function for HSPA13 Gene

Molecular function for HSPA13 Gene

UniProtKB/Swiss-Prot Function: Has peptide-independent ATPase activity

Gene Ontology (GO) - Molecular Function for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA13: view

Animal Model Products

CRISPR Products

miRNA for HSPA13 Gene

miRTarBase miRNAs that target HSPA13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA13 Gene

Localization for HSPA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA13 Gene

Microsome. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA13 Gene COMPARTMENTS Subcellular localization image for HSPA13 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 8131751
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with HSPA13: view

Pathways for HSPA13 Gene

SuperPathways for HSPA13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
genes like me logo Genes that share ontologies with HSPA13: view

No data available for Pathways by source for HSPA13 Gene

Transcripts for HSPA13 Gene

mRNA/cDNA for HSPA13 Gene

Unigene Clusters for HSPA13 Gene

Heat shock protein 70kDa family, member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1:
SP2: - - -
SP3: - -
SP4: - - -

Relevant External Links for HSPA13 Gene

GeneLoc Exon Structure for
HSPA13
ECgene alternative splicing isoforms for
HSPA13

Expression for HSPA13 Gene

mRNA expression in normal human tissues for HSPA13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA13 Gene

SOURCE GeneReport for Unigene cluster for HSPA13 Gene Hs.352341

mRNA Expression by UniProt/SwissProt for HSPA13 Gene

P48723-HSP13_HUMAN
Tissue specificity: Constitutively expressed in all tissues
genes like me logo Genes that share expressions with HSPA13: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSPA13 Gene

Orthologs for HSPA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA13 35
  • 99.5 (n)
  • 99.79 (a)
HSPA13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA13 35
  • 90.59 (n)
  • 93.84 (a)
HSPA13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA13 35
  • 92.92 (n)
  • 95.97 (a)
HSPA13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa13 35
  • 86.55 (n)
  • 90.66 (a)
Hspa13 16
Hspa13 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA13 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA13 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa13 35
  • 86.84 (n)
  • 91.08 (a)
chicken
(Gallus gallus)
Aves HSPA13 35
  • 72.41 (n)
  • 74.47 (a)
HSPA13 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA13 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa13 35
  • 68.23 (n)
  • 74.57 (a)
Str.9182 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2151 35
zebrafish
(Danio rerio)
Actinopterygii hspa13 35
  • 65.22 (n)
  • 68.95 (a)
hspa13 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea stc-1 35
  • 53.68 (n)
  • 47.74 (a)
stc-1 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSB2 36
  • 27 (a)
OneToOne
Species with no ortholog for HSPA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA13 Gene

ENSEMBL:
Gene Tree for HSPA13 (if available)
TreeFam:
Gene Tree for HSPA13 (if available)

Paralogs for HSPA13 Gene

Selected SIMAP similar genes for HSPA13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPA13: view

No data available for Paralogs for HSPA13 Gene

Variants for HSPA13 Gene

Sequence variations from dbSNP and Humsavar for HSPA13 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs12479 -- 14,372,948(-) ATATA(A/G)TAGAA utr-variant-3-prime
rs1882881 -- 14,382,665(+) CCGAT(G/T)TGATG intron-variant
rs2242661 -- 14,383,500(+) AGTTC(C/T)AGCCT upstream-variant-2KB
rs2242662 -- 14,383,727(+) TGCGG(C/G)GCCTG upstream-variant-2KB
rs2822637 -- 14,371,065(+) ATTTA(C/T)ATGCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSPA13 Gene

Variant ID Type Subtype PubMed ID
nsv913403 CNV Loss 21882294

Relevant External Links for HSPA13 Gene

HapMap Linkage Disequilibrium report
HSPA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA13 Gene

Disorders for HSPA13 Gene

(1) University of Copenhagen DISEASES for HSPA13 Gene

Relevant External Links for HSPA13

Genetic Association Database (GAD)
HSPA13
Human Genome Epidemiology (HuGE) Navigator
HSPA13
genes like me logo Genes that share disorders with HSPA13: view

No data available for UniProtKB/Swiss-Prot for HSPA13 Gene

Publications for HSPA13 Gene

  1. Stch encodes the 'ATPase core' of a microsomal stress 70 protein. (PMID: 8131751) Otterson G.A. … Kaye F.J. (EMBO J. 1994) 3 4 23
  2. Localization of STCH to human chromosome 21q11.1. (PMID: 8825657) Brodsky G. … Kaye F.J. (Genomics 1995) 2 3
  3. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70- like Stch. (PMID: 10675567) Kaye F.J. … Rose M.D. (FEBS Lett. 2000) 3 4
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HSPA13 Gene

  • antibodies-online proteins for HSPA13
  • antibodies-online antibodies for HSPA13
  • antibodies-online kits for HSPA13

Sources for HSPA13 Gene

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