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Aliases for HSPA13 Gene

Aliases for HSPA13 Gene

  • Heat Shock Protein Family A (Hsp70) Member 13 2 3 5
  • Stress-70 Protein Chaperone Microsome-Associated 60 KDa Protein 3 4
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kDa 2 3
  • Stress 70 Protein Chaperone, Microsome-Associated, 60kD 2 3
  • Heat Shock Protein 70kDa Family, Member 13 2 3
  • Microsomal Stress-70 Protein ATPase Core 3 4
  • STCH 3 4
  • Testis Secretory Sperm-Binding Protein Li 199a 3
  • Heat Shock Protein 70kDa Family Member 13 3
  • Microsomal Stress 70 Protein ATPase Core 3

External Ids for HSPA13 Gene

Previous HGNC Symbols for HSPA13 Gene

  • STCH

Previous GeneCards Identifiers for HSPA13 Gene

  • GC21M014666
  • GC21M015743
  • GC21M001113

Summaries for HSPA13 Gene

Entrez Gene Summary for HSPA13 Gene

  • The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSPA13 Gene

HSPA13 (Heat Shock Protein Family A (Hsp70) Member 13) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence.

UniProtKB/Swiss-Prot for HSPA13 Gene

  • Has peptide-independent ATPase activity.

Gene Wiki entry for HSPA13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA13 Gene

Genomics for HSPA13 Gene

Regulatory Elements for HSPA13 Gene

Enhancers for HSPA13 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSPA13 on UCSC Golden Path with GeneCards custom track

Promoters for HSPA13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSPA13 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSPA13 Gene

Chromosome:
21
Start:
14,371,115 bp from pter
End:
14,383,484 bp from pter
Size:
12,370 bases
Orientation:
Minus strand

Genomic View for HSPA13 Gene

Genes around HSPA13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA13 Gene

Proteins for HSPA13 Gene

  • Protein details for HSPA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48723-HSP13_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 13
    Protein Accession:
    P48723
    Secondary Accessions:
    • B2R616
    • Q8NE40

    Protein attributes for HSPA13 Gene

    Size:
    471 amino acids
    Molecular mass:
    51927 Da
    Quaternary structure:
    • Binds UBQLN2.

neXtProt entry for HSPA13 Gene

Proteomics data for HSPA13 Gene at MOPED

Post-translational modifications for HSPA13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA13 Gene

Domains & Families for HSPA13 Gene

Gene Families for HSPA13 Gene

Protein Domains for HSPA13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA13 Gene

Graphical View of Domain Structure for InterPro Entry

P48723

UniProtKB/Swiss-Prot:

HSP13_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA13: view

Function for HSPA13 Gene

Molecular function for HSPA13 Gene

UniProtKB/Swiss-Prot Function:
Has peptide-independent ATPase activity.

Phenotypes for HSPA13 Gene

GenomeRNAi human phenotypes for HSPA13:
genes like me logo Genes that share phenotypes with HSPA13: view

Animal Model Products

CRISPR Products

miRNA for HSPA13 Gene

miRTarBase miRNAs that target HSPA13

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA13 Gene

Localization for HSPA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSPA13 Gene

Microsome. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA13 Gene COMPARTMENTS Subcellular localization image for HSPA13 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle TAS 8131751
genes like me logo Genes that share ontologies with HSPA13: view

Pathways & Interactions for HSPA13 Gene

genes like me logo Genes that share pathways with HSPA13: view

Pathways by source for HSPA13 Gene

Gene Ontology (GO) - Biological Process for HSPA13 Gene

None

No data available for SIGNOR curated interactions for HSPA13 Gene

Drugs & Compounds for HSPA13 Gene

No Compound Related Data Available

Transcripts for HSPA13 Gene

mRNA/cDNA for HSPA13 Gene

Unigene Clusters for HSPA13 Gene

Heat shock protein 70kDa family, member 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA13 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
SP1:
SP2: - - -
SP3: - -
SP4: - - -

Relevant External Links for HSPA13 Gene

GeneLoc Exon Structure for
HSPA13
ECgene alternative splicing isoforms for
HSPA13

Expression for HSPA13 Gene

mRNA expression in normal human tissues for HSPA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA13 Gene

This gene is overexpressed in Stomach (9.7), Amniocyte (9.2), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA13 Gene



SOURCE GeneReport for Unigene cluster for HSPA13 Gene Hs.352341

mRNA Expression by UniProt/SwissProt for HSPA13 Gene

P48723-HSP13_HUMAN
Tissue specificity: Constitutively expressed in all tissues.
genes like me logo Genes that share expression patterns with HSPA13: view

Protein tissue co-expression partners for HSPA13 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for HSPA13 Gene

Orthologs for HSPA13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA13 35
  • 90.59 (n)
  • 93.84 (a)
HSPA13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA13 35
  • 92.92 (n)
  • 95.97 (a)
HSPA13 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa13 35
  • 86.55 (n)
  • 90.66 (a)
Hspa13 16
Hspa13 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA13 35
  • 99.5 (n)
  • 99.79 (a)
HSPA13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa13 35
  • 86.84 (n)
  • 91.08 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA13 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA13 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPA13 35
  • 72.41 (n)
  • 74.47 (a)
HSPA13 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA13 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa13 35
  • 68.23 (n)
  • 74.57 (a)
Str.9182 35
zebrafish
(Danio rerio)
Actinopterygii hspa13 35
  • 65.22 (n)
  • 68.95 (a)
hspa13 36
  • 68 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2151 35
worm
(Caenorhabditis elegans)
Secernentea stc-1 35
  • 53.68 (n)
  • 47.74 (a)
stc-1 36
  • 44 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSB2 36
  • 27 (a)
OneToOne
Species with no ortholog for HSPA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSPA13 Gene

ENSEMBL:
Gene Tree for HSPA13 (if available)
TreeFam:
Gene Tree for HSPA13 (if available)

Paralogs for HSPA13 Gene

(9) SIMAP similar genes for HSPA13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSPA13: view

No data available for Paralogs for HSPA13 Gene

Variants for HSPA13 Gene

Sequence variations from dbSNP and Humsavar for HSPA13 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2822637 -- 14,371,065(+) ATTTA(C/T)ATGCC downstream-variant-500B
rs2822638 -- 14,372,785(+) GGTCT(C/T)GGATA utr-variant-3-prime
rs2822639 -- 14,372,855(+) TTACC(A/G)ATTTT utr-variant-3-prime
rs2822640 -- 14,374,736(+) ATTAA(A/G)AATAC intron-variant
rs2822641 -- 14,375,182(+) GATCA(A/C)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA13 Gene

Variant ID Type Subtype PubMed ID
nsv913403 CNV Loss 21882294

Variation tolerance for HSPA13 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.15; 23.22% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSPA13 Gene

Disorders for HSPA13 Gene

Relevant External Links for HSPA13

Genetic Association Database (GAD)
HSPA13
Human Genome Epidemiology (HuGE) Navigator
HSPA13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA13

No disorders were found for HSPA13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA13 Gene

Publications for HSPA13 Gene

  1. Stch encodes the 'ATPase core' of a microsomal stress 70 protein. (PMID: 8131751) Otterson G.A. … Kaye F.J. (EMBO J. 1994) 3 4 23 67
  2. Localization of STCH to human chromosome 21q11.1. (PMID: 8825657) Brodsky G. … Kaye F.J. (Genomics 1995) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1. (PMID: 23303189) Bae J.S. … Park K. (J. Biol. Chem. 2013) 3

Products for HSPA13 Gene

Sources for HSPA13 Gene

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