Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSPA12B Gene

Aliases for HSPA12B Gene

  • Heat Shock 70kD Protein 12B 2 3
  • C20orf60 3 4
  • Chromosome 20 Open Reading Frame 60 2
  • Heat Shock 70 KDa Protein 12B 3
  • DJ1009E24.2 3

External Ids for HSPA12B Gene

Previous Symbols for HSPA12B Gene

  • C20orf60

Summaries for HSPA12B Gene

Entrez Gene Summary for HSPA12B Gene

  • The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

GeneCards Summary for HSPA12B Gene

HSPA12B (Heat Shock 70kD Protein 12B) is a Protein Coding gene. An important paralog of this gene is HSPA12A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12B Gene

Genomics for HSPA12B Gene

Genomic Location for HSPA12B Gene

Start:
3,732,667 bp from pter
End:
3,753,111 bp from pter
Size:
20,445 bases
Orientation:
Plus strand

Genomic View for HSPA12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12B Gene

Regulatory Elements for HSPA12B Gene

Proteins for HSPA12B Gene

  • Protein details for HSPA12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MM6-HS12B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 12B
    Protein Accession:
    Q96MM6
    Secondary Accessions:
    • D3DVX7
    • Q2TAK3
    • Q9BR52

    Protein attributes for HSPA12B Gene

    Size:
    686 amino acids
    Molecular mass:
    75688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPA12B Gene

Proteomics data for HSPA12B Gene at MOPED

Post-translational modifications for HSPA12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA12B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSPA12B Gene

Domains for HSPA12B Gene

Gene Families for HSPA12B Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA12B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HS12B_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • Q96MM6
genes like me logo Genes that share domains with HSPA12B: view

Function for HSPA12B Gene

Gene Ontology (GO) - Molecular Function for HSPA12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSPA12B Gene

Localization for HSPA12B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA12B Gene COMPARTMENTS Subcellular localization image for HSPA12B gene
Compartment Confidence
cytosol 2
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for HSPA12B Gene

Pathways for HSPA12B Gene

SuperPathways for HSPA12B Gene

No Data Available

Interacting Proteins for HSPA12B Gene

Gene Ontology (GO) - Biological Process for HSPA12B Gene

None

No data available for Pathways by source for HSPA12B Gene

Transcripts for HSPA12B Gene

Unigene Clusters for HSPA12B Gene

Heat shock 70kD protein 12B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
SP1: - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for HSPA12B Gene

GeneLoc Exon Structure for
HSPA12B
ECgene alternative splicing isoforms for
HSPA12B

Expression for HSPA12B Gene

mRNA expression in normal human tissues for HSPA12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSPA12B Gene

SOURCE GeneReport for Unigene cluster for HSPA12B Gene Hs.516854

mRNA Expression by UniProt/SwissProt for HSPA12B Gene

Q96MM6-HS12B_HUMAN
Tissue specificity: Highest expression in muscle and heart. Lower levels in liver and kidney.
genes like me logo Genes that share expressions with HSPA12B: view

Orthologs for HSPA12B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA12B 36
  • 99.85 (n)
  • 99.71 (a)
HSPA12B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSPA12B 36
  • 89.29 (n)
  • 94.52 (a)
HSPA12B 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA12B 36
  • 91.57 (n)
  • 96.91 (a)
HSPA12B 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa12b 36
  • 85.69 (n)
  • 94.01 (a)
Hspa12b 16
Hspa12b 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSPA12B 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA12B 37
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 37
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia HSPA12B 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9427 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12b 36
  • 70.74 (n)
  • 75.44 (a)
zebrafish
(Danio rerio)
Actinopterygii gng3 36
hspa12b 36
  • 65.9 (n)
  • 72.48 (a)
hspa12b 37
  • 69 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00573 36
  • 42.65 (n)
  • 28.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToMany
Species with no ortholog for HSPA12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12B Gene

ENSEMBL:
Gene Tree for HSPA12B (if available)
TreeFam:
Gene Tree for HSPA12B (if available)

Paralogs for HSPA12B Gene

Paralogs for HSPA12B Gene

Selected SIMAP similar genes for HSPA12B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSPA12B: view

Variants for HSPA12B Gene

Sequence variations from dbSNP and Humsavar for HSPA12B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs492010 -- 3,749,955(-) GAGCA(A/G)GGGGC intron-variant
rs509764 -- 3,735,810(+) TCCAG(A/G)TACAA intron-variant
rs516681 -- 3,749,561(-) TGGGG(C/G)AGAAA intron-variant
rs541760 -- 3,751,986(-) GCGCC(A/G)CATTT reference, synonymous-codon, missense
rs554799 -- 3,738,350(+) TTTAG(A/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12B Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
nsv912615 CNV Loss 21882294
nsv470536 CNV Loss 18288195
nsv833899 CNV Loss 17160897
nsv912617 CNV Loss 21882294
nsv828673 CNV Gain 20364138
nsv179720 CNV Loss 16902084

Relevant External Links for HSPA12B Gene

HapMap Linkage Disequilibrium report
HSPA12B

Disorders for HSPA12B Gene

Relevant External Links for HSPA12B

Genetic Association Database (GAD)
HSPA12B
Human Genome Epidemiology (HuGE) Navigator
HSPA12B
genes like me logo Genes that share disorders with HSPA12B: view

No data available for UniProtKB/Swiss-Prot for HSPA12B Gene

Publications for HSPA12B Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 49

Products for HSPA12B Gene

  • antibodies-online peptides for HSPA12B
  • antibodies-online antibodies for HSPA12B
  • antibodies-online kits for HSPA12B

Sources for HSPA12B Gene

Back to Top

Content