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Aliases for HSPA12B Gene

Aliases for HSPA12B Gene

  • Heat Shock Protein Family A (Hsp70) Member 12B 2 3 5
  • C20orf60 3 4
  • Chromosome 20 Open Reading Frame 60 2
  • Heat Shock 70 KDa Protein 12B 3
  • Heat Shock 70kD Protein 12B 2

External Ids for HSPA12B Gene

Previous HGNC Symbols for HSPA12B Gene

  • C20orf60

Previous GeneCards Identifiers for HSPA12B Gene

  • GC20P003661

Summaries for HSPA12B Gene

Entrez Gene Summary for HSPA12B Gene

  • The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for HSPA12B Gene

HSPA12B (Heat Shock Protein Family A (Hsp70) Member 12B) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. An important paralog of this gene is HSPA12A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12B Gene

Genomics for HSPA12B Gene

Regulatory Elements for HSPA12B Gene

Enhancers for HSPA12B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F003751 1.2 Ensembl ENCODE 44.3 +20.1 20106 3.1 CTCF KLF1 TFAP4 ESRRA PKNOX1 SAP130 CHD4 ARID4B EBF1 ZNF2 HSPA12B CDC25B SPEF1 CENPB AP5S1 ENSG00000229539 PANK2 PIR58376
GH20F003676 1.1 FANTOM5 Ensembl ENCODE 19.6 -52.9 -52934 6.1 PKNOX1 ATF1 MLX ARID4B SIN3A YBX1 ZNF48 GLIS2 ZNF143 ZNF207 ADAM33 HSPA12B SIGLEC1 CENPB GFRA4
GH20F003838 0.9 Ensembl ENCODE 14.6 +106.6 106634 1.8 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ENSG00000229539 CDC25B HSPA12B CENPB PANK2 SPEF1 VPS16 C20orf27 MAVS AP5S1
GH20F003731 0.2 ENCODE 13.6 +0.2 154 2.3 CEBPA CEBPB ZNF24 CEBPG ZBTB7A EZH2 HSPA12B PIR58376
GH20F003652 0.2 Ensembl 10.8 -79.5 -79467 1.2 KLF1 L3MBTL2 ARID1B ZFHX2 NCOR1 IKZF1 MAFK EGR2 MGA SIGLEC1 HSPA12B ATRN GFRA4 PIR59813
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSPA12B on UCSC Golden Path with GeneCards custom track

Promoters for HSPA12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001834941 433 1401 CEBPB ZBTB7A EZH2

Genomic Location for HSPA12B Gene

Chromosome:
20
Start:
3,732,667 bp from pter
End:
3,753,111 bp from pter
Size:
20,445 bases
Orientation:
Plus strand

Genomic View for HSPA12B Gene

Genes around HSPA12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12B Gene

Proteins for HSPA12B Gene

  • Protein details for HSPA12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MM6-HS12B_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 12B
    Protein Accession:
    Q96MM6
    Secondary Accessions:
    • D3DVX7
    • Q2TAK3
    • Q9BR52

    Protein attributes for HSPA12B Gene

    Size:
    686 amino acids
    Molecular mass:
    75688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPA12B Gene

Post-translational modifications for HSPA12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSPA12B Gene

Domains & Families for HSPA12B Gene

Gene Families for HSPA12B Gene

Protein Domains for HSPA12B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96MM6

UniProtKB/Swiss-Prot:

HS12B_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA12B: view

Function for HSPA12B Gene

Gene Ontology (GO) - Molecular Function for HSPA12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12B: view

Phenotypes for HSPA12B Gene

GenomeRNAi human phenotypes for HSPA12B:
genes like me logo Genes that share phenotypes with HSPA12B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA12B Gene

Localization for HSPA12B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA12B Gene COMPARTMENTS Subcellular localization image for HSPA12B gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSPA12B Gene

Pathways & Interactions for HSPA12B Gene

genes like me logo Genes that share pathways with HSPA12B: view

Pathways by source for HSPA12B Gene

Gene Ontology (GO) - Biological Process for HSPA12B Gene

None

No data available for SIGNOR curated interactions for HSPA12B Gene

Transcripts for HSPA12B Gene

Unigene Clusters for HSPA12B Gene

Heat shock 70kD protein 12B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
SP1: - -
SP2: -
SP3: -
SP4:
SP5: -
SP6:

Relevant External Links for HSPA12B Gene

GeneLoc Exon Structure for
HSPA12B
ECgene alternative splicing isoforms for
HSPA12B

Expression for HSPA12B Gene

mRNA expression in normal human tissues for HSPA12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA12B Gene

This gene is overexpressed in Brain (8.2) and Fetal gut (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPA12B Gene



Protein tissue co-expression partners for HSPA12B Gene

NURSA nuclear receptor signaling pathways regulating expression of HSPA12B Gene:

HSPA12B

SOURCE GeneReport for Unigene cluster for HSPA12B Gene:

Hs.516854

mRNA Expression by UniProt/SwissProt for HSPA12B Gene:

Q96MM6-HS12B_HUMAN
Tissue specificity: Highest expression in muscle and heart. Lower levels in liver and kidney.
genes like me logo Genes that share expression patterns with HSPA12B: view

Primer Products

No data available for mRNA differential expression in normal tissues for HSPA12B Gene

Orthologs for HSPA12B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA12B 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia HSPA12B 34 35
  • 91.57 (n)
cow
(Bos Taurus)
Mammalia HSPA12B 34 35
  • 89.29 (n)
mouse
(Mus musculus)
Mammalia Hspa12b 34 16 35
  • 85.69 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA12B 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA12B 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia HSPA12B 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12b 34
  • 70.74 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9427 34
zebrafish
(Danio rerio)
Actinopterygii hspa12b 34 35
  • 65.9 (n)
gng3 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00573 34
  • 42.65 (n)
Species where no ortholog for HSPA12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12B Gene

ENSEMBL:
Gene Tree for HSPA12B (if available)
TreeFam:
Gene Tree for HSPA12B (if available)

Paralogs for HSPA12B Gene

Paralogs for HSPA12B Gene

(1) SIMAP similar genes for HSPA12B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSPA12B: view

Variants for HSPA12B Gene

Sequence variations from dbSNP and Humsavar for HSPA12B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10716070 -- 3,743,353(+) AATTT(-/A)AAAAA intron-variant
rs111336770 -- 3,736,793(+) TGAGA(A/C)GGGCG intron-variant
rs111531950 -- 3,740,318(+) GAGTT(C/T)CCTCA intron-variant
rs111540710 -- 3,750,069(+) CGGCC(A/G)GCAGC reference, synonymous-codon
rs111630209 -- 3,738,565(+) ACTCC(A/G)GCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12B Gene

Variant ID Type Subtype PubMed ID
esv3575355 CNV gain 25503493
esv3645047 CNV loss 21293372
nsv179720 CNV deletion 16902084
nsv470536 CNV loss 18288195
nsv520565 CNV loss 19592680
nsv585284 CNV loss 21841781
nsv585285 CNV loss 21841781
nsv585286 CNV loss 21841781
nsv828673 CNV gain 20364138
nsv833899 CNV loss 17160897

Variation tolerance for HSPA12B Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA12B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA12B Gene

Disorders for HSPA12B Gene

Relevant External Links for HSPA12B

Genetic Association Database (GAD)
HSPA12B
Human Genome Epidemiology (HuGE) Navigator
HSPA12B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA12B

No disorders were found for HSPA12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA12B Gene

Publications for HSPA12B Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for HSPA12B Gene

Sources for HSPA12B Gene

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