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Aliases for HSPA12B Gene

Aliases for HSPA12B Gene

  • Heat Shock 70kD Protein 12B 2 3
  • C20orf60 3 4
  • Chromosome 20 Open Reading Frame 60 2
  • DJ1009E24.2 3

External Ids for HSPA12B Gene

Previous HGNC Symbols for HSPA12B Gene

  • C20orf60

Previous GeneCards Identifiers for HSPA12B Gene

  • GC20P003661

Summaries for HSPA12B Gene

Entrez Gene Summary for HSPA12B Gene

  • The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

GeneCards Summary for HSPA12B Gene

HSPA12B (Heat Shock 70kD Protein 12B) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular response to heat stress. An important paralog of this gene is HSPA12A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12B Gene

Genomics for HSPA12B Gene

Regulatory Elements for HSPA12B Gene

Genomic Location for HSPA12B Gene

3,732,667 bp from pter
3,753,111 bp from pter
20,445 bases
Plus strand

Genomic View for HSPA12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12B Gene

Proteins for HSPA12B Gene

  • Protein details for HSPA12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 12B
    Protein Accession:
    Secondary Accessions:
    • D3DVX7
    • Q2TAK3
    • Q9BR52

    Protein attributes for HSPA12B Gene

    686 amino acids
    Molecular mass:
    75688 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSPA12B Gene

Proteomics data for HSPA12B Gene at MOPED

Post-translational modifications for HSPA12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA12B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA12B Gene

Domains & Families for HSPA12B Gene

Gene Families for HSPA12B Gene

Protein Domains for HSPA12B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA12B: view

Function for HSPA12B Gene

Gene Ontology (GO) - Molecular Function for HSPA12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12B: view

Phenotypes for HSPA12B Gene

GenomeRNAi human phenotypes for HSPA12B:
genes like me logo Genes that share phenotypes with HSPA12B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA12B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA12B Gene

Localization for HSPA12B Gene

Subcellular locations from

Jensen Localization Image for HSPA12B Gene COMPARTMENTS Subcellular localization image for HSPA12B gene
Compartment Confidence
golgi apparatus 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HSPA12B Gene

Pathways & Interactions for HSPA12B Gene

genes like me logo Genes that share pathways with HSPA12B: view

Pathways by source for HSPA12B Gene

Interacting Proteins for HSPA12B Gene

Gene Ontology (GO) - Biological Process for HSPA12B Gene


No data available for SIGNOR curated interactions for HSPA12B Gene

Drugs & Compounds for HSPA12B Gene

No Compound Related Data Available

Transcripts for HSPA12B Gene

Unigene Clusters for HSPA12B Gene

Heat shock 70kD protein 12B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA12B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13
SP1: - -
SP2: -
SP3: -
SP5: -

Relevant External Links for HSPA12B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA12B Gene

mRNA expression in normal human tissues for HSPA12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSPA12B Gene

This gene is overexpressed in Brain (8.2) and Fetal gut (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSPA12B Gene

SOURCE GeneReport for Unigene cluster for HSPA12B Gene Hs.516854

mRNA Expression by UniProt/SwissProt for HSPA12B Gene

Tissue specificity: Highest expression in muscle and heart. Lower levels in liver and kidney.
genes like me logo Genes that share expression patterns with HSPA12B: view

Protein tissue co-expression partners for HSPA12B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HSPA12B Gene

Orthologs for HSPA12B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSPA12B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSPA12B 35
  • 89.29 (n)
  • 94.52 (a)
HSPA12B 36
  • 95 (a)
(Canis familiaris)
Mammalia HSPA12B 35
  • 91.57 (n)
  • 96.91 (a)
HSPA12B 36
  • 97 (a)
(Mus musculus)
Mammalia Hspa12b 35
  • 85.69 (n)
  • 94.01 (a)
Hspa12b 16
Hspa12b 36
  • 93 (a)
(Pan troglodytes)
Mammalia HSPA12B 35
  • 99.85 (n)
  • 99.71 (a)
HSPA12B 36
  • 100 (a)
(Monodelphis domestica)
Mammalia HSPA12B 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia HSPA12B 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 35 (a)
(Anolis carolinensis)
Reptilia HSPA12B 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12b 35
  • 70.74 (n)
  • 75.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9427 35
(Danio rerio)
Actinopterygii gng3 35
hspa12b 35
  • 65.9 (n)
  • 72.48 (a)
hspa12b 36
  • 69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00573 35
  • 42.65 (n)
  • 28.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for HSPA12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12B Gene

Gene Tree for HSPA12B (if available)
Gene Tree for HSPA12B (if available)

Paralogs for HSPA12B Gene

Paralogs for HSPA12B Gene

(1) SIMAP similar genes for HSPA12B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSPA12B: view

Variants for HSPA12B Gene

Sequence variations from dbSNP and Humsavar for HSPA12B Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs492010 -- 3,749,955(-) GAGCA(A/G)GGGGC intron-variant
rs509764 -- 3,735,810(+) TCCAG(A/G)TACAA intron-variant
rs516681 -- 3,749,561(-) TGGGG(C/G)AGAAA intron-variant
rs541760 -- 3,751,986(-) GCGCC(A/G)CATTT reference, synonymous-codon, downstream-variant-500B
rs554799 -- 3,738,350(+) TTTAG(A/G)AGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12B Gene

Variant ID Type Subtype PubMed ID
nsv520565 CNV Loss 19592680
nsv912615 CNV Loss 21882294
nsv470536 CNV Loss 18288195
nsv833899 CNV Loss 17160897
nsv912617 CNV Loss 21882294
nsv828673 CNV Gain 20364138
nsv179720 CNV Loss 16902084

Variation tolerance for HSPA12B Gene

Residual Variation Intolerance Score: 68.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA12B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA12B Gene

Disorders for HSPA12B Gene

Relevant External Links for HSPA12B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSPA12B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA12B Gene

Publications for HSPA12B Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. HSPA12B inhibits lipopolysaccharide-induced inflammatory response in human umbilical vein endothelial cells. (PMID: 25545050) Wu J. … Liu L. (J. Cell. Mol. Med. 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for HSPA12B Gene

Sources for HSPA12B Gene

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