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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSPA12A Gene

protein-coding   GIFtS: 53
GCID: GC10M118420

Heat Shock 70kDa Protein 12A

(Previous name: heat shock 70kD protein 12A)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock 70kDa Protein 12A1 2
Heat Shock 70kD Protein 12A1 2
KIAA04173 5
Heat Shock 70 KDa Protein 12A2

External Ids:    HGNC: 190221   Entrez Gene: 2592172   Ensembl: ENSG000001658687   OMIM: 6107015   UniProtKB: O433013   

Export aliases for HSPA12A gene to outside databases

Previous GC identifers: GC00U991243 GC10U900081 GC10M118095 GC10M112058


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HSPA12A Gene: 
HSPA12A (heat shock 70kDa protein 12A) is a protein-coding gene. Diseases associated with HSPA12A include schizophrenia. GO annotations related to this gene include ATP binding. An important paralog of this gene is HSPA12B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSPA12A gene promoter:
         LHX3b/Lhx3b   SREBP-1c   Olf-1   E47   SREBP-1b   C/EBPalpha   CHOP-10   SREBP-1a   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HSPA12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSPA12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.12   Ensembl cytogenetic band:  10q25.3   HGNC cytogenetic band: 10q25.3

HSPA12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSPA12A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M118420:  view genomic region     (about GC identifiers)

Start:
118,430,703 bp from pter      End:
118,502,085 bp from pter
Size:
71,383 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS12A_HUMAN, O43301 (See protein sequence)
Recommended Name: Heat shock 70 kDa protein 12A  
Size: 675 amino acids; 74978 Da
Sequence caution: Sequence=BAA24847.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for HSPA12A: NX_O43301

Explore proteomics data for HSPA12A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43301

  • HSPA12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSPA12A Protein Expression
    REFSEQ proteins: NP_079291.2  
    ENSEMBL proteins: 
     ENSP00000358211   ENSP00000466041   ENSP00000466927  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSP70: Heat shock proteins / HSP70

    1 InterPro protein domain:
     IPR026685 HSPA12

    Graphical View of Domain Structure for InterPro Entry O43301

    ProtoNet protein and cluster: O43301

    UniProtKB/Swiss-Prot: HS12A_HUMAN, O43301
    Similarity: Belongs to the heat shock protein 70 family


    HSPA12A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    HSPA12A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSPA12A:
     Big cells  Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSPA12A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSPA12A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/780 Interacting proteins for HSPA12A (O433012, 3 ENSP000003582114) via UniProtKB, MINT, STRING, and/or I2D (see all 780)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    NRCAMQ928233, ENSP000003683144I2D: score=2 STRING: ENSP00000368314
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ABCF3Q9NUQ82MINT-7945693 MINT-7947479
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSPA12A (HS12A)

    Search CenterWatch for drugs/clinical trials and news about HSPA12A / HS12A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSPA12A gene: 
    NM_025015.2  

    Unigene Cluster for HSPA12A:

    Heat shock 70kDa protein 12A
    Hs.648448  [show with all ESTs]
    Unigene Representative Sequence: BC041412
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369209(uc001lct.3 uc001lcu.3) ENST00000480802 ENST00000481291
    ENST00000468935
    miRNA
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    hsa-miR-345 hsa-miR-19b-2* hsa-miR-631 hsa-miR-10b* hsa-miR-1184 hsa-miR-378 hsa-miR-23a hsa-miR-761
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSPA12A

    Additional mRNA sequence: 

    AB007877.1 AK092127.1 AK294672.1 AK294884.1 BC041412.2 

    10 DOTS entries:

    DT.91654985  DT.415949  DT.95212944  DT.92423108  DT.121266282  DT.92423104  DT.70103489  DT.102825368 
    DT.102833658  DT.40108169 

    24/108 AceView cDNA sequences (see all 108):

    AL598554 BX477784 BE048045 CD518065 AU141865 BQ723586 AK023936 CA448640 
    AI374664 AA393528 AA398449 AB007877 W81404 BX280116 N77058 BM903968 
    BQ003691 BQ182948 BQ876472 BX955887 BQ722196 BM712644 AA351039 AL134466 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSPA12A expression in normal human tissues (normalized intensities)      HSPA12A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCAATGTA
    HSPA12A Expression
    About this image


    HSPA12A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 20 entries
             Globus Pallidus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Root Ganglion   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem SM30, NCr-fac & Meso-latp Progenitor
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   
     
     Colon (Gastrointestinal Tract)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See HSPA12A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSPA12A

    SOURCE GeneReport for Unigene cluster: Hs.648448

    UniProtKB/Swiss-Prot: HS12A_HUMAN, O43301
    Tissue specificity: Widely expressed with highest levels in brain, kidney and muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including HSPA12A: 
              Cellular Stress Responses in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSPA12A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HSPA12A gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hspa12a1 , 5 heat shock protein 12A1, 5 89.32(n)1
    96.59(a)1
      19 (54.51 cM)5
    734421  NM_175199.31  NP_780408.11 
     587957515 
    chicken
    (Gallus gallus)
    Aves HSPA12A1 heat shock 70kDa protein 12A 78.47(n)
    89.71(a)
      423917  XM_421779.3  XP_421779.3 
    lizard
    (Anolis carolinensis)
    Reptilia HSPA12A6
    heat shock 70kDa protein 12A
    88(a)
    1 ↔ 1
    GL343206.1(1900869-1976782)
    zebrafish
    (Danio rerio)
    Actinopterygii hspa12a6
    si:dkey-61p9.66
    si:dkey-61p9.6
    81(a)
    35(a)
    1 ↔ 1
    possible ortholog
    17(21053107-21087268)
    4(61390108-61418626)


    ENSEMBL Gene Tree for HSPA12A (if available)
    TreeFam Gene Tree for HSPA12A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSPA12A gene
    HSPA12B2  
    1 SIMAP similar gene for HSPA12A using alignment to 3 protein entries:     HS12A_HUMAN (see all proteins):
    HSPA12B

    HSPA12A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1563 SNPs in HSPA12A are shown (see all 1563)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464004041,2
    C--118431599(+) AAGGCA/GGGAAA 1 -- ut310--------
    rs412843701,2
    --118431707(+) TTCTTC/TGACCC 1 -- ut310--------
    rs1853678951,2
    --118431791(+) GGTCAA/GCGACC 1 -- ut310--------
    rs1887464441,2
    --118431803(+) CTCAGC/GACACA 1 -- ut310--------
    rs412843721,2
    C,F--118431822(+) CTTAGG/ATTGTT 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1818993161,2
    --118431919(+) GAATCC/TGTGAC 1 -- ut310--------
    rs1846589241,2
    --118431952(+) AGAAGG/TGTCTG 1 -- ut310--------
    rs1381181991,2
    --118432030(+) TGCTCA/GGTCTT 1 -- ut310--------
    rs1495723821,2
    C--118432037(+) TCTTGC/TGTACA 1 -- ut310--------
    rs1442832181,2
    C--118432038(+) CTTGCG/TTACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HSPA12A (118430703 - 118502085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HSPA12A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666855CNV Deletion23128226
    esv2741306CNV Deletion23290073
    esv2092121CNV Deletion18987734
    esv2741295CNV Deletion23290073
    esv1009263CNV Insertion20482838
    esv1124964CNV Insertion17803354
    nsv7562CNV Loss18451855
    nsv825576CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610701    OMIM disorders: --

    2 diseases for HSPA12A:    About MalaCards
    schizophrenia    


    HSPA12A for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSPA12A
    Human Genome Epidemiology (HuGE) Navigator: HSPA12A (2 documents)

    Export disorders for HSPA12A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSPA12A gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with HSPA12A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two Hsp70 family members expressed in atherosclerotic lesions. (PubMed id 12552099)1, 2, 3 Han Z.... Breslow J.L. (2003)
    2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    5. Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. (PubMed id 15601604)1, 9 Pongrac J.L....Mirnics K. (2004)
    6. Genome-wide association analyses in East Asians identi fy new susceptibility loci for colorectal cancer. (PubMed id 23263487)1 Jia W.H....Zheng W. (2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 259217 HGNC: 19022 AceView: HSPA12A Ensembl:ENSG00000165868 euGenes: HUgn259217
    ECgene: HSPA12A H-InvDB: HSPA12A

    (According to HUGE)
    About This Section
    HUGE: KIAA0417

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSPA12A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSPA12A gene:
    Search GeneIP for patents involving HSPA12A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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