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Aliases for HSPA12A Gene

Aliases for HSPA12A Gene

  • Heat Shock 70kDa Protein 12A 2 3
  • KIAA0417 4 6
  • Heat Shock 70kD Protein 12A 2

External Ids for HSPA12A Gene

Previous GeneCards Identifiers for HSPA12A Gene

  • GC00U991243
  • GC10U900081
  • GC10M118095
  • GC10M118420
  • GC10M112058

Summaries for HSPA12A Gene

GeneCards Summary for HSPA12A Gene

HSPA12A (Heat Shock 70kDa Protein 12A) is a Protein Coding gene. An important paralog of this gene is HSPA12B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12A Gene

Genomics for HSPA12A Gene

Regulatory Elements for HSPA12A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSPA12A Gene

Start:
116,671,192 bp from pter
End:
116,850,179 bp from pter
Size:
178,988 bases
Orientation:
Minus strand

Genomic View for HSPA12A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSPA12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12A Gene

Proteins for HSPA12A Gene

  • Protein details for HSPA12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43301-HS12A_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 12A
    Protein Accession:
    O43301
    Secondary Accessions:

    Protein attributes for HSPA12A Gene

    Size:
    675 amino acids
    Molecular mass:
    74978 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24847.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HSPA12A Gene

Proteomics data for HSPA12A Gene at MOPED

Post-translational modifications for HSPA12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSPA12A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSPA12A Gene

Domains for HSPA12A Gene

Gene Families for HSPA12A Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HSPA12A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43301

UniProtKB/Swiss-Prot:

HS12A_HUMAN :
  • O43301
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA12A: view

Function for HSPA12A Gene

Gene Ontology (GO) - Molecular Function for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12A: view

Phenotypes for HSPA12A Gene

genes like me logo Genes that share phenotypes with HSPA12A: view

Animal Model Products

CRISPR Products

miRNA for HSPA12A Gene

miRTarBase miRNAs that target HSPA12A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA12A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSPA12A Gene

Localization for HSPA12A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA12A Gene COMPARTMENTS Subcellular localization image for HSPA12A gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA12A Gene

Pathways for HSPA12A Gene

SuperPathways for HSPA12A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cellular Stress Responses in human,mouse,rat
    • Heat Shock Proteins & Chaperones in human,mouse,rat

Gene Ontology (GO) - Biological Process for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for Pathways by source for HSPA12A Gene

Transcripts for HSPA12A Gene

Unigene Clusters for HSPA12A Gene

Heat shock 70kDa protein 12A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSPA12A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12A Gene

No ASD Table

Relevant External Links for HSPA12A Gene

GeneLoc Exon Structure for
HSPA12A
ECgene alternative splicing isoforms for
HSPA12A

Expression for HSPA12A Gene

mRNA expression in normal human tissues for HSPA12A Gene

mRNA differential expression in normal tissues according to GTEx for HSPA12A Gene

This gene is overexpressed in Nerve - Tibial (4.8) and Brain - Frontal Cortex (BA9) (4.0).

Protein differential expression in normal tissues for HSPA12A Gene

This gene is overexpressed in Frontal cortex (20.0), Brain (13.0), Spinal cord (11.2), and Retina (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSPA12A Gene

SOURCE GeneReport for Unigene cluster for HSPA12A Gene Hs.648448

mRNA Expression by UniProt/SwissProt for HSPA12A Gene

O43301-HS12A_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, kidney and muscle.
genes like me logo Genes that share expressions with HSPA12A: view

Expression partners for HSPA12A Gene

In Situ Assay Products

Orthologs for HSPA12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPA12A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSPA12A 35
  • 92.35 (n)
  • 97.19 (a)
HSPA12A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA12A 35
  • 91.69 (n)
  • 97.89 (a)
HSPA12A 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hspa12a 35
  • 89.32 (n)
  • 96.59 (a)
Hspa12a 16
Hspa12a 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSPA12A 35
  • 99.66 (n)
  • 99.83 (a)
HSPA12A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa12a 35
  • 89.37 (n)
  • 97.03 (a)
oppossum
(Monodelphis domestica)
Mammalia HSPA12A 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA12A 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSPA12A 35
  • 78.59 (n)
  • 90.26 (a)
HSPA12A 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSPA12A 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12a 35
  • 77.47 (n)
  • 84.85 (a)
zebrafish
(Danio rerio)
Actinopterygii hspa12a 36
  • 81 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for HSPA12A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12A Gene

ENSEMBL:
Gene Tree for HSPA12A (if available)
TreeFam:
Gene Tree for HSPA12A (if available)

Paralogs for HSPA12A Gene

Paralogs for HSPA12A Gene

Selected SIMAP similar genes for HSPA12A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSPA12A: view

Variants for HSPA12A Gene

Sequence variations from dbSNP and Humsavar for HSPA12A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs15641 -- 116,672,803(-) TCAAA(A/C)GCTAA utr-variant-3-prime
rs722564 -- 116,791,320(-) TGTCA(A/G)ATTTT intron-variant
rs726525 -- 116,844,675(+) GGACC(C/T)GCAGT intron-variant
rs731762 -- 116,775,410(-) GCCCC(C/T)GTCCT intron-variant
rs733216 -- 116,692,299(-) AGATG(C/T)CCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12A Gene

Variant ID Type Subtype PubMed ID
esv2092121 CNV Deletion 18987734
esv2741295 CNV Deletion 23290073
esv2741306 CNV Deletion 23290073
esv2666855 CNV Deletion 23128226
nsv825576 CNV Gain 20364138
esv1009263 CNV Insertion 20482838
esv1124964 CNV Insertion 17803354
nsv7562 CNV Loss 18451855

Relevant External Links for HSPA12A Gene

HapMap Linkage Disequilibrium report
HSPA12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA12A Gene

Disorders for HSPA12A Gene

Relevant External Links for HSPA12A

Genetic Association Database (GAD)
HSPA12A
Human Genome Epidemiology (HuGE) Navigator
HSPA12A

No disorders were found for HSPA12A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HSPA12A Gene

Publications for HSPA12A Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48
  3. Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. (PMID: 15601604) Pongrac J.L. … Mirnics K. (Biol. Psychiatry 2004) 3 23
  4. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 48

Products for HSPA12A Gene

Sources for HSPA12A Gene

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