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Aliases for HSPA12A Gene

Aliases for HSPA12A Gene

  • Heat Shock Protein Family A (Hsp70) Member 12A 2 3 5
  • Heat Shock 70kDa Protein 12A 2
  • Heat Shock 70kD Protein 12A 2
  • KIAA0417 4

External Ids for HSPA12A Gene

Previous GeneCards Identifiers for HSPA12A Gene

  • GC00U991243
  • GC10U900081
  • GC10M118095
  • GC10M118420
  • GC10M112058

Summaries for HSPA12A Gene

GeneCards Summary for HSPA12A Gene

HSPA12A (Heat Shock Protein Family A (Hsp70) Member 12A) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. An important paralog of this gene is HSPA12B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12A Gene

Genomics for HSPA12A Gene

Regulatory Elements for HSPA12A Gene

Enhancers for HSPA12A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F116707 0.6 ENCODE 21.1 +142.3 142278 1.2 RNF2 ZNF140 C10orf82 HSPA12A LOC105378499 RPL5P27
GH10F116769 1.1 Ensembl ENCODE 19.5 +79.6 79597 2.6 ELF3 ATF1 ARID4B RARA FOS CREM HMG20B SP5 CEBPB NR2F2 HSPA12A C10orf82 LOC105378499 LOC105378498 RPL5P27
GH10F116694 0.9 ENCODE 18.2 +156.2 156161 1.1 ARID4B DMAP1 THRB ZNF48 ZSCAN9 RARA EGR2 THAP11 SP5 PPARG HSPA12A C10orf82 RPL5P27
GH10F116690 0.8 Ensembl ENCODE 17.6 +159.4 159399 2.4 SCRT1 CTCF ZIC2 RAD21 POLR2A SCRT2 GLIS1 SMC3 CTBP2 KDM1A HSPA12A C10orf82 RPL5P27
GH10F116687 1.1 Ensembl ENCODE 17.5 +162.3 162297 1.8 CTCF HSPA12A C10orf82 RPL5P27
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSPA12A on UCSC Golden Path with GeneCards custom track

Promoters for HSPA12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000362477 1314 1401 INSM2 KLF17 ARID4B SIN3A BMI1 FEZF1 ZNF680 SP3 REST ZNF518A

Genomic Location for HSPA12A Gene

Chromosome:
10
Start:
116,671,192 bp from pter
End:
116,850,814 bp from pter
Size:
179,623 bases
Orientation:
Minus strand

Genomic View for HSPA12A Gene

Genes around HSPA12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12A Gene

Proteins for HSPA12A Gene

  • Protein details for HSPA12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43301-HS12A_HUMAN
    Recommended name:
    Heat shock 70 kDa protein 12A
    Protein Accession:
    O43301

    Protein attributes for HSPA12A Gene

    Size:
    675 amino acids
    Molecular mass:
    74978 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA24847.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HSPA12A Gene

Post-translational modifications for HSPA12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSPA12A Gene

Domains & Families for HSPA12A Gene

Gene Families for HSPA12A Gene

Protein Domains for HSPA12A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HSPA12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43301

UniProtKB/Swiss-Prot:

HS12A_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA12A: view

Function for HSPA12A Gene

Gene Ontology (GO) - Molecular Function for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12A: view

Phenotypes for HSPA12A Gene

genes like me logo Genes that share phenotypes with HSPA12A: view

Animal Model Products

miRNA for HSPA12A Gene

miRTarBase miRNAs that target HSPA12A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA12A Gene

Localization for HSPA12A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSPA12A Gene COMPARTMENTS Subcellular localization image for HSPA12A gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA12A Gene

Pathways & Interactions for HSPA12A Gene

genes like me logo Genes that share pathways with HSPA12A: view

Pathways by source for HSPA12A Gene

Gene Ontology (GO) - Biological Process for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for SIGNOR curated interactions for HSPA12A Gene

Transcripts for HSPA12A Gene

Unigene Clusters for HSPA12A Gene

Heat shock 70kDa protein 12A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12A Gene

No ASD Table

Relevant External Links for HSPA12A Gene

GeneLoc Exon Structure for
HSPA12A
ECgene alternative splicing isoforms for
HSPA12A

Expression for HSPA12A Gene

mRNA expression in normal human tissues for HSPA12A Gene

mRNA differential expression in normal tissues according to GTEx for HSPA12A Gene

This gene is overexpressed in Nerve - Tibial (x4.8) and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for HSPA12A Gene

This gene is overexpressed in Frontal cortex (20.0), Brain (13.0), Spinal cord (11.2), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA12A Gene



Protein tissue co-expression partners for HSPA12A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA12A Gene:

HSPA12A

SOURCE GeneReport for Unigene cluster for HSPA12A Gene:

Hs.648448

mRNA Expression by UniProt/SwissProt for HSPA12A Gene:

O43301-HS12A_HUMAN
Tissue specificity: Widely expressed with highest levels in brain, kidney and muscle.
genes like me logo Genes that share expression patterns with HSPA12A: view

Primer Products

Orthologs for HSPA12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPA12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSPA12A 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia HSPA12A 34 35
  • 92.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSPA12A 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSPA12A 34 35
  • 91.69 (n)
oppossum
(Monodelphis domestica)
Mammalia HSPA12A 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hspa12a 34
  • 89.37 (n)
mouse
(Mus musculus)
Mammalia Hspa12a 34 16 35
  • 89.32 (n)
chicken
(Gallus gallus)
Aves HSPA12A 34 35
  • 78.59 (n)
lizard
(Anolis carolinensis)
Reptilia HSPA12A 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12a 34
  • 77.47 (n)
zebrafish
(Danio rerio)
Actinopterygii hspa12a 35
  • 81 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToMany
Species where no ortholog for HSPA12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12A Gene

ENSEMBL:
Gene Tree for HSPA12A (if available)
TreeFam:
Gene Tree for HSPA12A (if available)

Paralogs for HSPA12A Gene

Paralogs for HSPA12A Gene

(1) SIMAP similar genes for HSPA12A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSPA12A: view

Variants for HSPA12A Gene

Sequence variations from dbSNP and Humsavar for HSPA12A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1004155 -- 116,731,257(-) TCCTC(C/T)GGCCA intron-variant
rs1004156 -- 116,731,037(-) CCTGG(A/G)ACAGA intron-variant
rs1004157 -- 116,731,008(-) CAGAG(A/G)AGCTG intron-variant
rs1006551 -- 116,741,051(-) GCTGG(C/T)GAACG intron-variant
rs1006552 -- 116,740,930(-) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12A Gene

Variant ID Type Subtype PubMed ID
esv1009263 CNV insertion 20482838
esv1124964 CNV insertion 17803354
esv2092121 CNV deletion 18987734
esv2666855 CNV deletion 23128226
esv2741295 CNV deletion 23290073
esv2741306 CNV deletion 23290073
esv3624662 CNV gain 21293372
esv3624663 CNV gain 21293372
esv3624664 CNV loss 21293372
nsv1143653 CNV deletion 24896259
nsv7562 CNV deletion 18451855
nsv825576 CNV gain 20364138

Variation tolerance for HSPA12A Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSPA12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSPA12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA12A Gene

Disorders for HSPA12A Gene

Relevant External Links for HSPA12A

Genetic Association Database (GAD)
HSPA12A
Human Genome Epidemiology (HuGE) Navigator
HSPA12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSPA12A

No disorders were found for HSPA12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA12A Gene

Publications for HSPA12A Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z. … Breslow J.L. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 46 64
  4. Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. (PMID: 15601604) Pongrac J.L. … Mirnics K. (Biol. Psychiatry 2004) 3 22 64
  5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4 64

Products for HSPA12A Gene

Sources for HSPA12A Gene

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