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Aliases for HSPA12A Gene

Aliases for HSPA12A Gene

  • Heat Shock Protein Family A (Hsp70) Member 12A 2 3 5
  • Heat Shock 70kDa Protein 12A 2
  • Heat Shock 70kD Protein 12A 2
  • KIAA0417 4

External Ids for HSPA12A Gene

Previous GeneCards Identifiers for HSPA12A Gene

  • GC00U991243
  • GC10U900081
  • GC10M118095
  • GC10M118420
  • GC10M112058

Summaries for HSPA12A Gene

GeneCards Summary for HSPA12A Gene

HSPA12A (Heat Shock Protein Family A (Hsp70) Member 12A) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence (REACTOME). An important paralog of this gene is HSPA12B.

Additional gene information for HSPA12A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSPA12A Gene

Genomics for HSPA12A Gene

GeneHancer (GH) Regulatory Elements for HSPA12A Gene

Promoters and enhancers for HSPA12A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I116847 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.7 1734 3 ARID4B SIN3A FEZF1 ZNF48 YY1 GLIS2 ZNF213 ATF7 RUNX3 KLF13 ENSG00000225302 HSPA12A ENO4 SHTN1 PIR57757
GH10I116741 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 560.1 +108.3 108290 2.7 KLF17 ZNF76 SIN3A ZNF335 GLIS2 SCRT2 FOS EGR2 ZNF202 SP3 HSPA12A RPL5P27 C10orf82
GH10I116769 Enhancer 1 Ensembl ENCODE 19.6 +79.6 79596 2.6 ELF3 FOXA2 ARID4B RAD21 RARA FOS HMG20B SP5 CEBPB ELF1 HSPA12A C10orf82 LOC105378499 LOC105378498 RPL5P27
GH10I116694 Enhancer 0.8 ENCODE 18.2 +156.2 156161 1.1 ARID4B DMAP1 THRB ZNF48 ZSCAN9 RARA THAP11 EGR2 SP5 PPARG HSPA12A C10orf82 RPL5P27
GH10I116721 Enhancer 0.8 Ensembl ENCODE 17.9 +128.4 128382 2.3 FOXA2 ZNF529 ARID4B ZIC2 ZFHX2 GLIS2 POLR2A GLIS1 ZFP36 RCOR1 HSPA12A C10orf82 RPL5P27
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSPA12A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSPA12A gene promoter:

Genomic Locations for HSPA12A Gene

Genomic Locations for HSPA12A Gene
179,623 bases
Minus strand

Genomic View for HSPA12A Gene

Genes around HSPA12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSPA12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSPA12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSPA12A Gene

Proteins for HSPA12A Gene

  • Protein details for HSPA12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock 70 kDa protein 12A
    Protein Accession:

    Protein attributes for HSPA12A Gene

    675 amino acids
    Molecular mass:
    74978 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA24847.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HSPA12A Gene

Post-translational modifications for HSPA12A Gene

No Post-translational modifications

No data available for DME Specific Peptides for HSPA12A Gene

Domains & Families for HSPA12A Gene

Gene Families for HSPA12A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HSPA12A Gene


Suggested Antigen Peptide Sequences for HSPA12A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HSPA12A: view

Function for HSPA12A Gene

Phenotypes From GWAS Catalog for HSPA12A Gene

Gene Ontology (GO) - Molecular Function for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSPA12A: view

Phenotypes for HSPA12A Gene

genes like me logo Genes that share phenotypes with HSPA12A: view

Animal Model Products

miRNA for HSPA12A Gene

miRTarBase miRNAs that target HSPA12A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSPA12A Gene

Localization for HSPA12A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSPA12A gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA,HDA 19056867
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HSPA12A Gene

Pathways & Interactions for HSPA12A Gene

genes like me logo Genes that share pathways with HSPA12A: view

Pathways by source for HSPA12A Gene

Gene Ontology (GO) - Biological Process for HSPA12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSPA12A: view

No data available for SIGNOR curated interactions for HSPA12A Gene

Drugs & Compounds for HSPA12A Gene

No Compound Related Data Available

Transcripts for HSPA12A Gene

Unigene Clusters for HSPA12A Gene

Heat shock 70kDa protein 12A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSPA12A Gene

No ASD Table

Relevant External Links for HSPA12A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSPA12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSPA12A Gene

mRNA differential expression in normal tissues according to GTEx for HSPA12A Gene

This gene is overexpressed in Nerve - Tibial (x4.8) and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for HSPA12A Gene

This gene is overexpressed in Frontal cortex (20.0), Brain (13.0), Spinal cord (11.2), and Retina (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSPA12A Gene

Protein tissue co-expression partners for HSPA12A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSPA12A Gene:


SOURCE GeneReport for Unigene cluster for HSPA12A Gene:


mRNA Expression by UniProt/SwissProt for HSPA12A Gene:

Tissue specificity: Widely expressed with highest levels in brain, kidney and muscle.

Evidence on tissue expression from TISSUES for HSPA12A Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with HSPA12A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HSPA12A Gene

Orthologs for HSPA12A Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSPA12A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSPA12A 33 34
  • 99.66 (n)
(Bos Taurus)
Mammalia HSPA12A 33 34
  • 92.35 (n)
(Ornithorhynchus anatinus)
Mammalia HSPA12A 34
  • 92 (a)
(Canis familiaris)
Mammalia HSPA12A 33 34
  • 91.69 (n)
(Monodelphis domestica)
Mammalia HSPA12A 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Hspa12a 33
  • 89.37 (n)
(Mus musculus)
Mammalia Hspa12a 33 16 34
  • 89.32 (n)
(Gallus gallus)
Aves HSPA12A 33 34
  • 78.59 (n)
(Anolis carolinensis)
Reptilia HSPA12A 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hspa12a 33
  • 77.47 (n)
(Danio rerio)
Actinopterygii hspa12a 34
  • 81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for HSPA12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSPA12A Gene

Gene Tree for HSPA12A (if available)
Gene Tree for HSPA12A (if available)

Paralogs for HSPA12A Gene

Paralogs for HSPA12A Gene

(1) SIMAP similar genes for HSPA12A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSPA12A: view

Variants for HSPA12A Gene

Sequence variations from dbSNP and Humsavar for HSPA12A Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000019915 -- 116,812,194(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000024372 -- 116,735,384(-) C/T intron_variant
rs1000035860 -- 116,814,608(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000083428 -- 116,742,177(-) C/A intron_variant
rs1000121582 -- 116,821,028(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSPA12A Gene

Variant ID Type Subtype PubMed ID
esv1009263 CNV insertion 20482838
esv1124964 CNV insertion 17803354
esv2092121 CNV deletion 18987734
esv2666855 CNV deletion 23128226
esv2741295 CNV deletion 23290073
esv2741306 CNV deletion 23290073
esv3624662 CNV gain 21293372
esv3624663 CNV gain 21293372
esv3624664 CNV loss 21293372
nsv1143653 CNV deletion 24896259
nsv7562 CNV deletion 18451855
nsv825576 CNV gain 20364138

Variation tolerance for HSPA12A Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSPA12A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSPA12A Gene

Disorders for HSPA12A Gene

Additional Disease Information for HSPA12A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HSPA12A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSPA12A Gene

Publications for HSPA12A Gene

  1. Two Hsp70 family members expressed in atherosclerotic lesions. (PMID: 12552099) Han Z … Breslow JL (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
  2. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58
  4. Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia. (PMID: 15601604) Pongrac JL … Mirnics K (Biological psychiatry 2004) 3 22 58
  5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4 58

Products for HSPA12A Gene

Sources for HSPA12A Gene

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