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Aliases for HSP90B1 Gene

Aliases for HSP90B1 Gene

  • Heat Shock Protein 90kDa Beta (Grp94), Member 1 2 3
  • GRP94 3 4 6
  • Tra1 3 4 6
  • Heat Shock Protein 90 KDa Beta Member 1 3 4
  • Tumor Rejection Antigen (Gp96) 1 2 3
  • 94 KDa Glucose-Regulated Protein 3 4
  • Tumor Rejection Antigen 1 3 4
  • GP96 3 6
  • Epididymis Secretory Sperm Binding Protein Li 125m 3
  • Stress-Inducible Tumor Rejection Antigen Gp96 3
  • Endothelial Cell (HBMEC) Glycoprotein 3
  • Epididymis Luminal Protein 35 3
  • Gp96 Homolog 4
  • Endoplasmin 3
  • HEL-S-125m 3
  • GRP-94 4
  • HEL35 3
  • ECGP 3

External Ids for HSP90B1 Gene

Previous HGNC Symbols for HSP90B1 Gene

  • TRA1

Previous GeneCards Identifiers for HSP90B1 Gene

  • GC12P102848
  • GC12P104324
  • GC12P101383

Summaries for HSP90B1 Gene

Entrez Gene Summary for HSP90B1 Gene

  • This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

GeneCards Summary for HSP90B1 Gene

HSP90B1 (Heat Shock Protein 90kDa Beta (Grp94), Member 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is TRAP1.

UniProtKB/Swiss-Prot for HSP90B1 Gene

  • Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Gene Wiki entry for HSP90B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90B1 Gene

Genomics for HSP90B1 Gene

Regulatory Elements for HSP90B1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSP90B1 Gene

103,930,107 bp from pter
103,953,645 bp from pter
23,539 bases
Plus strand

Genomic View for HSP90B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90B1 Gene

Proteins for HSP90B1 Gene

  • Protein details for HSP90B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q96A97

    Protein attributes for HSP90B1 Gene

    803 amino acids
    Molecular mass:
    92469 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23.

    Three dimensional structures from OCA and Proteopedia for HSP90B1 Gene

neXtProt entry for HSP90B1 Gene

Proteomics data for HSP90B1 Gene at MOPED

Post-translational modifications for HSP90B1 Gene

  • Ubiquitination at Lys75, Lys114, Lys142, Lys161, Lys168, Lys270, Lys434, Lys455, Lys486, and Lys671
  • Glycosylation at Asn62, Asn107, Asn217, Asn445, Asn481, and Asn502
  • Modification sites at PhosphoSitePlus

Other Protein References for HSP90B1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HSP90B1 (gp96/HSP90B1)
  • Cell Signaling Technology (CST) Antibodies for HSP90B1 (GRP94)

No data available for DME Specific Peptides for HSP90B1 Gene

Domains for HSP90B1 Gene

Gene Families for HSP90B1 Gene

  • HSPC :Heat shock proteins / HSPC

Suggested Antigen Peptide Sequences for HSP90B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P14625
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90B1: view

Function for HSP90B1 Gene

Molecular function for HSP90B1 Gene

UniProtKB/Swiss-Prot Function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Gene Ontology (GO) - Molecular Function for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 11958450
GO:0005509 calcium ion binding TAS 10497210
GO:0005515 protein binding IPI 11907036
GO:0005524 ATP binding IEA --
GO:0019903 protein phosphatase binding IDA 19000834
genes like me logo Genes that share ontologies with HSP90B1: view
genes like me logo Genes that share phenotypes with HSP90B1: view

Animal Models for HSP90B1 Gene

MGI Knock Outs for HSP90B1:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSP90B1 Gene

Localization for HSP90B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90B1 Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Jensen Localization Image for HSP90B1 Gene COMPARTMENTS Subcellular localization image for HSP90B1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
golgi apparatus 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endosome 1
extracellular 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IDA 10497210
genes like me logo Genes that share ontologies with HSP90B1: view

Pathways for HSP90B1 Gene

genes like me logo Genes that share pathways with HSP90B1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 15620698
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006457 protein folding --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006950 response to stress --
genes like me logo Genes that share ontologies with HSP90B1: view

Compounds for HSP90B1 Gene

(34) Novoseek inferred chemical compound relationships for HSP90B1 Gene

Compound -log(P) Hits PubMed IDs
tunicamycin 79.5 11
geldanamycin 71.6 9
radicicol 67 4
thapsigargin 57.1 5
iodoacetamide 46.1 1
genes like me logo Genes that share compounds with HSP90B1: view

Transcripts for HSP90B1 Gene

Unigene Clusters for HSP90B1 Gene

Heat shock protein 90kDa beta (Grp94), member 1:
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90B1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: -
SP7: - - - - -
SP8: -
SP9: - - - - - - - -

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^ 21

Relevant External Links for HSP90B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSP90B1 Gene

mRNA expression in normal human tissues for HSP90B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90B1 Gene

SOURCE GeneReport for Unigene cluster for HSP90B1 Gene Hs.192374

genes like me logo Genes that share expressions with HSP90B1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90B1 Gene

Orthologs for HSP90B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSP90B1 35
  • 99.75 (n)
  • 99.88 (a)
HSP90B1 36
  • 100 (a)
(Bos Taurus)
Mammalia HSP90B1 35
  • 92.4 (n)
  • 97.88 (a)
HSP90B1 36
  • 98 (a)
(Canis familiaris)
Mammalia HSP90B1 35
  • 92.78 (n)
  • 98.01 (a)
HSP90B1 36
  • 98 (a)
(Mus musculus)
Mammalia Hsp90b1 35
  • 89.24 (n)
  • 96.01 (a)
Hsp90b1 16
Hsp90b1 36
  • 97 (a)
(Monodelphis domestica)
Mammalia HSP90B1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia HSP90B1 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Hsp90b1 35
  • 89.15 (n)
  • 96.01 (a)
(Gallus gallus)
Aves HSP90B1 35
  • 81.36 (n)
  • 90.05 (a)
HSP90B1 36
  • 91 (a)
(Anolis carolinensis)
Reptilia HSP90B1 36
  • 88 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68448 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90b1 35
  • 76.13 (n)
  • 85.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13888 35
(Danio rerio)
Actinopterygii hsp90b1 35
  • 75.45 (n)
  • 85.17 (a)
hsp90b1 36
  • 83 (a)
tra1 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001424 35
  • 59.91 (n)
  • 63.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gp93 35
  • 60.14 (n)
  • 61.92 (a)
Gp93 36
  • 60 (a)
(Caenorhabditis elegans)
Secernentea CELE_T05E11.3 35
  • 62.28 (n)
  • 64.25 (a)
enpl-1 36
  • 63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 36
  • 46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SHD 35
  • 58.64 (n)
  • 53.09 (a)
(Zea mays)
Liliopsida Zm.5048 35
(Oryza sativa)
Liliopsida Os.12393 35
Os06g0716700 35
  • 56.5 (n)
  • 52.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5238 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4613 36
  • 67 (a)
Species with no ortholog for HSP90B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSP90B1 Gene

Gene Tree for HSP90B1 (if available)
Gene Tree for HSP90B1 (if available)

Paralogs for HSP90B1 Gene

Paralogs for HSP90B1 Gene

Selected SIMAP similar genes for HSP90B1 Gene using alignment to 5 proteins: Pseudogenes for HSP90B1 Gene

genes like me logo Genes that share paralogs with HSP90B1: view

Variants for HSP90B1 Gene

Sequence variations from dbSNP and Humsavar for HSP90B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6615 -- 103,934,201(+) GATAC(C/T)CAGCA reference, synonymous-codon
rs7645 -- 103,947,325(+) GAGCC(C/T)GAAGA reference, synonymous-codon
rs1051185 -- 103,947,763(+) CCCTT(C/T)TCCCC utr-variant-3-prime
rs1165683 -- 103,933,648(+) AATAG(A/G)CAAGA intron-variant
rs1165684 -- 103,934,770(+) AATCT(C/T)GGCTC intron-variant

Relevant External Links for HSP90B1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HSP90B1 Gene

Disorders for HSP90B1 Gene

(1) University of Copenhagen DISEASES for HSP90B1 Gene

(27) Novoseek inferred disease relationships for HSP90B1 Gene

Disease -log(P) Hits PubMed IDs
shock 67.4 39
tumors 32.8 48
cell damage 28.8 2
cancer 26.6 21
bipolar disorder 15.3 5

Relevant External Links for HSP90B1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSP90B1: view

No data available for UniProtKB/Swiss-Prot for HSP90B1 Gene

Publications for HSP90B1 Gene

  1. Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins. (PMID: 2377606) Maki R.G. … Srivastava P.K. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  2. p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. (PMID: 8617772) Chavany C. … Neckers L. (J. Biol. Chem. 1996) 3 23 25
  3. Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B. (PMID: 12397072) Zhang J. … Herscovitz H. (J. Biol. Chem. 2003) 3 23
  4. Cloning and expression of the Escherichia coli K1 outer membrane protein A receptor, a gp96 homologue. (PMID: 12654781) Prasadarao N.V. … Sukumaran S.K. (Infect. Immun. 2003) 3 23
  5. GRP94 (94 kDa glucose-regulated protein) suppresses ischemic neuronal cell death against ischemia/reperfusion injury. (PMID: 12925009) Bando Y. … Tohyama M. (Eur. J. Neurosci. 2003) 23 48

Products for HSP90B1 Gene

Sources for HSP90B1 Gene

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