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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90B1 Gene

protein-coding   GIFtS: 67
GCID: GC12P104324

heat shock protein 90kDa beta (Grp94), member 1

(Previous name: tumor rejection antigen (gp96) 1 )
(Previous symbol: TRA1)
 Explore 68 diseases affiliated with
HSP90B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSP90B1    

Aliases
for HSP90B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock Protein 90kDa Beta (Grp94), Member 11 2     94 KDa Glucose-Regulated Protein2 3
GRP941 2 3 5     ECGP2
TRA11 2 3 5     Endoplasmin1
GP961 2 5     Endothelial Cell (HBMEC) Glycoprotein2
Tumor Rejection Antigen (Gp96) 11 2     Stress-Inducible Tumor Rejection Antigen Gp962
Heat Shock Protein 90 KDa Beta Member 12 3     GRP-943
Tumor Rejection Antigen 12 3     Gp96 Homolog3

External Ids:    HGNC: 120281   Entrez Gene: 71842   Ensembl: ENSG000001665987   OMIM: 1911755   UniProtKB: P146253   

Export aliases for HSP90B1 gene to outside databases

Previous GC identifers: GC12P102848 GC12P101383


Summaries
for HSP90B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSP90B1:
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in
stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum.
Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a
microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15.
(provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625
Function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with
CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum
associated degradation (ERAD). Has ATPase activity

Gene Wiki entry for HSP90B1


Genomic Views
for HSP90B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSP90B1 gene promoter:
         CREB   TBP   IRF-2   STAT1   deltaCREB   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): HSP90B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSP90B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2-q24.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.2-q24.3

HSP90B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90B1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P104324:  view genomic region     (about GC identifiers)

Start:
 104,323,885 bp from pter      End:
 104,347,423 bp from pter
Size:
 23,539 bases      Orientation:
 plus strand

Proteins
for HSP90B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625 (See protein sequence)
Recommended Name: Endoplasmin precursor  
Size: 803 amino acids; 92469 Da
Subunit: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3,
EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11,
HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very
low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with
OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4
and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity)
Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
fractions from stage I to stage IV
Secondary accessions: Q96A97

Explore the universe of human proteins at neXtProt for HSP90B1: NX_P14625

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14625

    • HSP90B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003290.1  
    ENSEMBL proteins: 
     ENSP00000446748   ENSP00000299767   ENSP00000446266   ENSP00000450215  
    Reactome Protein details: P14625
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for HSP90B1
    OriGene Purified Protein: HSP90B1
    OriGene Protein Over-expression Lysate: HSP90B1
    OriGene Custom Protein Services for HSP90B1 
    GenScript Custom Purified and Recombinant Proteins Services for HSP90B1
    Novus Biologicals HSP90B1 Proteins
    Novus Biologicals HSP90B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IDA10497210
    GO:0005829cytosol IDA9596688
    GO:0030496midbody IDA15166316


    HSP90B1 for ontologies           About GeneDecksing



    HSP90B1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90B1
    R&D Systems Antibodies for HSP90B1 (gp96/HSP90B1)
    Cell Signaling Technology (CST) Antibodies for HSP90B1  (GRP94)
    OriGene Antibodies (see all 3): HSP90B1
    OriGene Custom Antibody Services for HSP90B1 
    GenScript Superior Antibodies for HSP90B1
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    Abcam antibodies for HSP90B1 
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    ThermoFisher Antibody for HSP90B1

    Assay Products for HSP90B1: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HSP90B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSP90B1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 ATPase-like_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P14625

    ProtoNet protein and cluster: P14625

    2 Blocks protein families:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625
    Similarity: Belongs to the heat shock protein 90 family


    Function
    for HSP90B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625
    Function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with
    CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum
    associated degradation (ERAD). Has ATPase activity

    miRNA
    Products:            		miRTarBase miRNAs that target HSP90B1:
    hsa-mir-192 (MIRT004158)

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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90B1 (see all 15):
    hsa-miR-206 hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-1 hsa-miR-23c hsa-miR-181d hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90B1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: HSP90B1
    OriGene siRNA: HSP90B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90B1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSP90B1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90B1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90B1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HSP90B1 (NM_003299)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90B1 

    Cell Line
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    Search LifeMap BioReagents cell lines for HSP90B1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90B1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11958450
    GO:0005509calcium ion binding TAS10497210
    GO:0005515protein binding IPI18264092
    GO:0005524ATP binding IEA--
    GO:0019903protein phosphatase binding IDA19000834


    HSP90B1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HSP90B1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-outs for HSP90B1: Hsp90b1tm1.2Alee Hsp90b1tm1Yarg Hsp90b1tm1.1Zhli
         7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hsp90b1):
     cardiovascular system  cellular  embryogenesis  growth/size  immune system 
     mortality/aging  no phenotypic analysis 

    HSP90B1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HSP90B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    		Development_Glucocorticoid receptor signaling0.27
    		Development Glucocorticoid receptor signaling0.27
    2Immune System
    		Immune System1.00
    		Innate Immune System0.46
    3Activation of Chaperone Genes by ATF6-alpha
    		Activation of Chaperone Genes by ATF6-alpha1.00
    		Activation of Chaperones by ATF6-alpha0.62
    4Immune response Antigen presentation by MHC class I
    		Immune response Antigen presentation by MHC class I1.00
    		Immune response_Antigen presentation by MHC class I0.92
    5Development IGF-RI signaling
    		Signal transduction_AKT signaling0.49
    		Signal transduction AKT signaling0.49

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for HSP90B1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Selected targets of GCR-alpha
    Signal transduction AKT signaling


    1 Cell Signaling Technology (CST) Pathway for HSP90B1
        Translational Control

    1 Tocris Bioscience Pathway for HSP90B1
        MAPK Pathway

    5 GeneGo (Thomson Reuters) Pathways for HSP90B1
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling

    2 BioSystems Pathways for HSP90B1 
        SIDS Susceptibility Pathways
    IL6-mediated signaling events

    5/9        Reactome Pathways for HSP90B1 (see all 9)
        Toll-Like Receptors Cascades
    Expression of HSP90B1 (Endoplasmin)
    Activation of Chaperones by ATF6-alpha
    Metabolism of proteins
    Trafficking and processing of endosomal TLR


    4         Kegg Pathways  (Kegg details for HSP90B1):
        Protein processing in endoplasmic reticulum
    NOD-like receptor signaling pathway
    Pathways in cancer
    Prostate cancer


    HSP90B1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSP90B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/849 Interacting proteins for HSP90B1 (P146252, 3 ENSP000002997674) via UniProtKB, MINT, STRING, and/or I2D (see all 849)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2EP193882, 3, ENSP000002155874MINT-7945693 MINT-8267085 I2D: score=2 STRING: ENSP00000215587
    CSNK2A1P684002, 3, ENSP000002172444MINT-14550 I2D: score=4 STRING: ENSP00000217244
    LMNAP025452, 3MINT-7945693 MINT-7947479 I2D: score=1 
    TNFRSF1BP203332, 3MINT-49442 I2D: score=2 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA15620698
    GO:0006457protein folding IEA--
    GO:0006950response to stress ----
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0015031protein transport NAS15845869


    HSP90B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSP90B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90B1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for HSP90B1

    Compounds for HSP90B1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCT 018159Hsp90 inhibitor[171009-07-7]
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    Macbecin IHsp90 inhibitor[73341-72-7]
    GeduninHsp90 inhibitor; anticancer and antimalarial activity[2753-30-2]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    8 DrugBank Compounds for HSP90B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Methoxy-2-(2-Methoxyethoxy)Ethane-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    N-Ethyl-5'-Carboxamido Adenosine-- --target--17139284 17016423 10592235
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown8617772 14660597 9428803
    2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE-- --target--10592235
    2-Chlorodideoxyadenosine-- 114849-58-0target--10592235
    METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE-- --target--10592235
    Radicicol-- --target--10592235

    10/34 Novoseek chemical compound relationships for HSP90B1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 79.5 13 16920763 (1), 17612505 (1), 18029041 (1), 9268304 (1) (see all 11)
    geldanamycin 71.6 13 9428803 (2), 12446770 (2), 9622079 (1), 10816561 (1) (see all 7)
    radicicol 67 10 10816561 (2), 12970348 (1), 10816560 (1)
    thapsigargin 57.1 5 17612505 (1), 9268304 (1), 11389688 (1), 12401114 (1) (see all 5)
    iodoacetamide 46.1 2 9268304 (1)
    17-(allylamino)-17-demethoxygeldanamycin 43.7 2 9622079 (1)
    lactacystin 38 1 11562776 (1)
    tert-butylhydroperoxide 35.6 1 9582315 (1)
    atp 32.4 33 9030582 (4), 7890810 (3), 15236592 (3), 19553200 (2) (see all 14)
    glucose 31.6 34 18331622 (3), 10797260 (2), 7987045 (1), 18029041 (1) (see all 22)

    Search CenterWatch for drugs/clinical trials and news about HSP90B1 / ENPL 

    Transcripts
    for HSP90B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSP90B1 gene: 
    NM_003299.2  

    Unigene Cluster for HSP90B1:

    Heat shock protein 90kDa beta (Grp94), member 1
    Hs.192374  [show with all ESTs]
    Unigene Representative Sequence: NM_003299
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549334 ENST00000299767(uc001tkb.1 uc010swg.1 uc009zui.1)
    ENST00000548622 ENST00000540297 ENST00000548462 ENST00000550479 ENST00000551983
    ENST00000552051 ENST00000550595

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90B1 (see all 15):
    hsa-miR-206 hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-1 hsa-miR-23c hsa-miR-181d hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90B1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90B1 (see all 7)
    OriGene shRNA RFP: HSP90B1
    OriGene siRNA: HSP90B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90B1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF087988.1 AJ890084.1 AK025459.1 AK025862.1 AK295262.1 AK298996.1 AK300521.1 AY040226.1 
    BC009195.2 BC066656.1 X15187.1 

    24/85 DOTS entries (see all 85):

    DT.65288659  DT.100891995  DT.95171177  DT.100891984  DT.91773982  DT.100891973  DT.100891987  DT.100891980 
    DT.91773968  DT.91838582  DT.100891989  DT.95171180  DT.100891999  DT.121182994  DT.91993952  DT.121182970 
    DT.95171374  DT.121182896  DT.100891975  DT.121182948  DT.121182963  DT.91940969  DT.121182707  DT.95171165 

    24/1593 AceView cDNA sequences (see all 1593):

    CB158946 CA416734 BM781466 BM787598 BM974085 BU078790 CA415738 BU159691 
    CB158213 AU125444 AI582554 AI057274 CD514322 BM974980 BP357434 BQ478164 
    BP354412 AW607694 CA841707 AL044047 BU786258 AI671051 W57980 AA329243 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90B1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
    SP1:                          -                 -                                                                                                     -     -   
    SP2:                          -                 -                                                                                                     -     -   
    SP3:                          -                 -           -     -     -     -     -     -     -     -     -     -                                             
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                        -   

    ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^ 21
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for HSP90B1

    Expression
    for HSP90B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HSP90B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    Primitive StreakNotochordPrimitive Streak
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See HSP90B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSP90B1

    SOURCE GeneReport for Unigene cluster: Hs.192374
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90B1 (see all 7): 
              Cancer Drug Targets in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HSP90B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HSP90B1 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HSP90B11 heat shock protein 90kDa beta (Grp94), member 1 82.12(n)
    91.69(a)    		   374163  NM_204289.1  NP_989620.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HSP90B16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(18171869-18181959)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684482 hypothetical protein MGC68448 78.16(n)    BC060352.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tra12 tumor rejection antigen (gp96) 1 76.5(n)   386590  BC063951.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Gp931 Glycoprotein 93 59.8(n)
    61.39(a)    		   43354  NM_143344.2  NP_651601.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_T05E11.31 Protein T05E11.3 62.95(n)
    65.87(a)    		   178014  NM_069679.5  NP_502080.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SHD1 endoplasmin-like protein 58.52(n)
    52.84(a)    		   828520  NM_118552.3  NP_194150.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.123932 Oryza sativa (japonica cultivar-group) mRNA for ferredoxin, more 71.4(n)    AK102478.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria htpG6
    		 protein refolding molecular co-chaperone Hsp90, Hs...
    		 39(a)
    		 possible ortholog
    		 Chromosome(494344-496218)


    ENSEMBL Gene Tree for HSP90B1 (if available)
    TreeFam Gene Tree for HSP90B1 (if available) 

    Paralogs
    for HSP90B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90B1 gene
    HSP90AB12  TRAP12  HSP90AA12  
    10 SIMAP similar genes for HSP90B1 using alignment to 5 protein entries:     ENPL_HUMAN (see all proteins):
    TRA1    GRP94c    HSP90AA2    HSP90AB1    HSP90AA1    HSP90AB4P
    HSP90B2P    HSP90AB3P    TRAP1    HSP90AA4P

    HSP90B1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HSP90B1
    PGOHUM00000247287 PGOHUM00000244793


    Genomic Variants
    for HSP90B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/380 NCBI SNPs in HSP90B1 are shown (see all 380)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs11656771,2
    		C,F,O,A,H,--104322144(+) TCCCAC/TCATCA 2 -- int1 us2k122Minor allele frequency- T:0.28NA EA NS WA CSA 2672
    rs11656781,2
    		C,F,O,A,H,--104322184(+) GCTCTA/GTTTTG 2 -- us2k1 int132Minor allele frequency- G:0.29NS EA NA MN WA CSA 3340
    rs170349161,2
    		C,F,H,--104322214(+) AGTTCT/CCTCCA 3 -- us2k1 int110Minor allele frequency- C:0.12NA NS EA WA 912
    rs1433788381,2
    		--104322228(+) GCAGCA/GCCAAC 3 -- us2k1 int10--------
    rs1174734981,2
    		--104322302(+) AATTGG/AAGGAA 3 -- us2k1 int11Minor allele frequency- A:0.01EA 120
    rs1483768021,2
    		--104322323(+) AGTTGA/TGCTGT 3 -- us2k1 int10--------
    rs751401001,2
    		F,--104322334(+) GAAATG/ACAGAA 3 -- us2k1 int11Minor allele frequency- A:0.08WA 118
    rs1872284391,2
    		--104322369(+) CTCTCA/GAAACA 3 -- us2k1 int10--------
    rs1908665181,2
    		--104322535(+) AAATTG/TGGCAG 3 -- us2k1 int10--------
    rs1400480641,2
    		--104322561(+) CACCAC/TAACAC 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for HSP90B1 (104323885 - 104347423 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSP90B1: --
    Human Gene Mutation Database (HGMD): HSP90B1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90B1

    Disorders / Diseases
    for HSP90B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSP90B1 for disorders           About GeneDecksing

    OMIM gene information: 191175    OMIM disorders: --

    20/68 diseases for HSP90B1 (see all 68):    About MalaCards
    retinol binding protein    von willebrand's disease    clostridium difficile    squamous cell carcinoma
    oral cavity cancer    myasthenia gravis    laryngeal squamous cell carcinoma    globozoospermia
    oral squamous cell carcinoma    atrial fibrillation    esophageal squamous cell carcinoma    bipolar disorder
    hepatitis b    chronic lymphocytic leukemia    malignant mesothelioma    acute myeloid leukemia
    myasthenia    fanconi's anemia    lymphocytic leukemia    pick's disease

    1 disease from the University of Copenhagen DISEASES database for HSP90B1:
    Cancer

    10/27 Novoseek disease relationships for HSP90B1 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 67.4 46 11562776 (2), 9622079 (1), 15952740 (1), 9268304 (1) (see all 38)
    tumors 32.8 65 18331622 (6), 10797260 (5), 20400973 (2), 17278882 (2) (see all 35)
    cell damage 28.8 3 11113529 (2)
    cancer 26.6 26 16297569 (6), 14984057 (2), 15742415 (2), 10797260 (1) (see all 14)
    bipolar disorder 15.3 5 17805476 (4), 19125190 (1)
    solid tumor 14.7 1 10424404 (1)
    breast carcinoma 9.73 6 18190237 (2), 10424404 (2)
    colon cancer 5.01 9 15742415 (5), 10797260 (2)
    myeloma 2.9 2 15236592 (1), 18629835 (1)
    hepatocellular carcinoma 2.08 6 15069714 (2), 11335099 (1), 11229675 (1), 15810071 (1)

    Genetic Association Database (GAD): HSP90B1
    Human Genome Epidemiology (HuGE) Navigator: HSP90B1 (6 documents)

    Export disorders for HSP90B1 gene to outside databases

    Publications
    for HSP90B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90B1 gene, integrated from 9 sources (see all 393):
    (articles sorted by number of sources associating them with HSP90B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. (PubMed id 8617772)1, 7, 9 Chavany C....Neckers L. (1996)
    2. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)1, 2, 9 Meunier L....Hendershot L.M. (2002)
    3. Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins. (PubMed id 2377606)1, 2, 9 Maki R.G.... Srivastava P.K. (1990)
    4. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2 Christianson J.C.... Kopito R.R. (2008)
    5. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
    6. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    7. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 3 Chen B.... Monteiro A. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)

    External Searches for HSP90B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSP90B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7184 HGNC: 12028 AceView: TRA1 Ensembl:ENSG00000166598 euGenes: HUgn7184
    ECgene: HSP90B1 Kegg: 7184 H-InvDB: HSP90B1

    Other Databases showing HSP90B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSP90B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90B1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSP90B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSP90B1 gene:
    Search GeneIP for patents involving HSP90B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    for HSP90B1 gene

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