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HSP90B1 Gene

protein-coding   GIFtS: 66
GCID: GC12P104324

Heat Shock Protein 90kDa Beta (Grp94), Member 1

(Previous name: tumor rejection antigen (gp96) 1)
(Previous symbol: TRA1)
  See HSP90B1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Protein 90kDa Beta (Grp94), Member 11 2     HEL-S-125m2
TRA11 2 3 5     HEL352
GRP942 3 5     endoplasmin2
Tumor Rejection Antigen (Gp96) 11 2     Endothelial Cell (HBMEC) Glycoprotein2
Heat Shock Protein 90 KDa Beta Member 12 3     Epididymis Luminal Protein 352
Tumor Rejection Antigen 12 3     Epididymis Secretory Sperm Binding Protein Li 125m2
94 KDa Glucose-Regulated Protein2 3     Stress-Inducible Tumor Rejection Antigen Gp962
GP962 5     GRP-943
ECGP2     Gp96 Homolog3

External Ids:    HGNC: 120281   Entrez Gene: 71842   Ensembl: ENSG000001665987   OMIM: 1911755   UniProtKB: P146253   

Export aliases for HSP90B1 gene to outside databases

Previous GC identifers: GC12P102848 GC12P101383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSP90B1 Gene:
This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles
in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic
reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor
formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene
on chromosomes 1 and 15. (provided by RefSeq, Aug 2012)

GeneCards Summary for HSP90B1 Gene:
HSP90B1 (heat shock protein 90kDa beta (Grp94), member 1) is a protein-coding gene. Diseases associated with HSP90B1 include globozoospermia. GO annotations related to this gene include unfolded protein binding and calcium ion binding. An important paralog of this gene is TRAP1.

UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625
Function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated
with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic
reticulum associated degradation (ERAD). Has ATPase activity

Gene Wiki entry for HSP90B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90B1 gene promoter:
         CREB   TBP   IRF-2   STAT1   deltaCREB   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): HSP90B1 promoter sequence
   Search Chromatin IP Primers for HSP90B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2-q24.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q24.2-q24.3

HSP90B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90B1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P104324:  view genomic region     (about GC identifiers)

Start:
104,323,885 bp from pter      End:
104,347,423 bp from pter
Size:
23,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625 (See protein sequence)
Recommended Name: Endoplasmin precursor  
Size: 803 amino acids; 92469 Da
Subunit: Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3,
EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising
DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but
not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic
reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By
similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner
(By similarity). Interacts with METTL23
1 PDB 3D structure from and Proteopedia for HSP90B1:
4NH9 (3D)    
Secondary accessions: Q96A97

Explore the universe of human proteins at neXtProt for HSP90B1: NX_P14625

Explore proteomics data for HSP90B1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys75, Lys114, Lys142, Lys161, Lys168, Lys270, Lys434, Lys455, Lys486, Lys671
  • Glycosylation2 at Asn62, Asn107, Asn217, Asn445, Asn481, Asn502
  • Modification sites at PhosphoSitePlus

  • See HSP90B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003290.1  
    ENSEMBL proteins: 
     ENSP00000446748   ENSP00000299767   ENSP00000446266   ENSP00000450215  
    Reactome Protein details: P14625

    HSP90B1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene MassSpec for HSP90B1
    OriGene Custom Protein Services for HSP90B1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90B1
    Novus Biologicals HSP90B1 Proteins
    Novus Biologicals HSP90B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSP90B1 

    HSP90B1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90B1
    R&D Systems Antibodies for HSP90B1 (gp96/HSP90B1)
    Cell Signaling Technology (CST) Antibodies for HSP90B1  (GRP94)
    OriGene Antibodies for HSP90B1
    OriGene Custom Antibody Services for HSP90B1
    Novus Biologicals HSP90B1 Antibodies
    Abcam antibodies for HSP90B1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HSP90B1
    LSBio Antibodies in human, mouse, rat for HSP90B1

    HSP90B1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90B1
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    GenScript Custom Assay Services for HSP90B1
    Enzo Life Sciences assays for HSP90B1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSP90B1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    Selected InterPro protein domains (see all 6):
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR015566 Endoplasmin
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry P14625

    ProtoNet protein and cluster: P14625

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: ENPL_HUMAN, P14625
    Similarity: Belongs to the heat shock protein 90 family


    Find genes that share domains with HSP90B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ENPL_HUMAN, P14625
    Function: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated
    with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic
    reticulum associated degradation (ERAD). Has ATPase activity

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IDA11958450
    GO:0005509calcium ion binding TAS10497210
    GO:0005515protein binding IPI11907036
    GO:0005524ATP binding IEA--
    GO:0019903protein phosphatase binding IDA19000834
         
    Find genes that share ontologies with HSP90B1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSP90B1:
     G0/1 arrest  Increased G1 DNA content 

         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Hsp90b1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with HSP90B1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSP90B1: Hsp90b1tm1.2Alee Hsp90b1tm1Yarg Hsp90b1tm1.1Zhli

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSP90B1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSP90B1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSP90B1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSP90B1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSP90B1:
    hsa-mir-128-3p (MIRT045853), hsa-mir-335-5p (MIRT017651), hsa-mir-16-5p (MIRT004368), hsa-mir-130b-3p (MIRT020159), hsa-mir-484 (MIRT041729), hsa-mir-192-5p (MIRT004158), hsa-mir-148a-3p (MIRT025974), hsa-mir-92a-3p (MIRT049100), hsa-mir-1 (MIRT023707), hsa-mir-223-3p (MIRT007086), hsa-mir-15a-5p (MIRT003874)

    Block miRNA regulation of human, mouse, rat HSP90B1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90B1 (see all 15):
    hsa-miR-206 hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-1 hsa-miR-23c hsa-miR-181d hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidHSP90B1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSP90B1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90B1

    Gene Editing
    Products:
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    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90B1 (see all 7)
    OriGene ORF clones in mouse, rat for HSP90B1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSP90B1 (NM_003299)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90B1
    Addgene plasmids for HSP90B1 

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90B1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90B1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ENPL_HUMAN, P14625: Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome
    fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    golgi apparatus2
    nucleus2
    plasma membrane2
    cytoskeleton1
    endosome1
    extracellular1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005783endoplasmic reticulum TAS16130169
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0005789endoplasmic reticulum membrane IDA10497210
    GO:0005829cytosol IDA9596688

    Find genes that share ontologies with HSP90B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSP90B1 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by ATF6-alpha0.00
    Activation of Chaperones by ATF6-alpha0.00
    2Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class A Receptors0.00
    3CDK-mediated phosphorylation and removal of Cdc6
    Immune response Antigen presentation by MHC class I0.68
    4Development IGF 1 receptor signaling
    Signal transduction AKT signaling0.49
    5Glioma
    Prostate cancer0.39


    Find genes that share SuperPaths with HSP90B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HSP90B1
        Translational Control

    1 Tocris Bioscience Pathway for HSP90B1
        MAPK Pathway

    5 GeneGo (Thomson Reuters) Pathways for HSP90B1
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling

    2 BioSystems Pathways for HSP90B1
        SIDS Susceptibility Pathways
    IL6-mediated signaling events

    3 Reactome Pathways for HSP90B1
        Scavenging by Class A Receptors
    Trafficking and processing of endosomal TLR
    ATF6-alpha activates chaperone genes


    Selected Kegg Pathways  (Kegg details for HSP90B1) (see all 7):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    NOD-like receptor signaling pathway
    Estrogen signaling pathway
    Thyroid hormone synthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90B1 (see all 7): 
              Cancer Drug Targets in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSP90B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90B1 (P146252, 3 ENSP000002997674) via UniProtKB, MINT, STRING, and/or I2D (see all 1003)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206289P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000227322P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000228333P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000231321P287022, 3MINT-7947479 I2D: score=1 
    ENSG00000235712P287022, 3MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA15620698
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0006457protein folding IEA--
    GO:0006950response to stress ----
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--

    Find genes that share ontologies with HSP90B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HSP90B1
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSP90B1 (ENPL)

    8 DrugBank Compounds for HSP90B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1-Methoxy-2-(2-Methoxyethoxy)Ethane-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    N-Ethyl-5'-Carboxamido Adenosine-- --target--17139284 17016423 10592235
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown8617772 14660597 9428803
    2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE-- --target--10592235
    2-Chlorodideoxyadenosine-- 114849-58-0target--10592235
    METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE-- --target--10592235
    Radicicol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90B1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tunicamycin 79.5 13 16920763 (1), 17612505 (1), 18029041 (1), 9268304 (1) (see all 11)
    geldanamycin 71.6 13 9428803 (2), 12446770 (2), 9622079 (1), 10816561 (1) (see all 7)
    radicicol 67 10 10816561 (2), 12970348 (1), 10816560 (1)
    thapsigargin 57.1 5 17612505 (1), 9268304 (1), 11389688 (1), 12401114 (1) (see all 5)
    iodoacetamide 46.1 2 9268304 (1)
    17-(allylamino)-17-demethoxygeldanamycin 43.7 2 9622079 (1)
    lactacystin 38 1 11562776 (1)
    tert-butylhydroperoxide 35.6 1 9582315 (1)
    atp 32.4 33 9030582 (4), 7890810 (3), 15236592 (3), 19553200 (2) (see all 14)
    glucose 31.6 34 18331622 (3), 10797260 (2), 7987045 (1), 18029041 (1) (see all 22)



    Find genes that share compounds with HSP90B1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSP90B1 gene: 
    NM_003299.2  

    Unigene Cluster for HSP90B1:

    Heat shock protein 90kDa beta (Grp94), member 1
    Hs.192374  [show with all ESTs]
    Unigene Representative Sequence: NM_003299
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549334 ENST00000299767(uc001tkb.1 uc010swg.1 uc009zui.1)
    ENST00000548622 ENST00000540297 ENST00000548462 ENST00000550479 ENST00000551983
    ENST00000552051 ENST00000550595
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HSP90B1 (see all 15):
    hsa-miR-206 hsa-miR-181c hsa-miR-130a* hsa-miR-181a hsa-miR-1 hsa-miR-23c hsa-miR-181d hsa-miR-223
    SwitchGear 3'UTR luciferase reporter plasmidHSP90B1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSP90B1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90B1
    Clone
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    OriGene clones in human, mouse for HSP90B1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSP90B1 (NM_003299)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90B1
    Addgene plasmids for HSP90B1 
    Primer
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    OriGene qPCR primer pairs and template standards for HSP90B1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90B1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90B1
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90B1
      QuantiFast Probe-based Assays in human, mouse, rat HSP90B1

    Additional mRNA sequence: 

    AF087988.1 AJ890084.1 AK025459.1 AK025862.1 AK295262.1 AK298996.1 AK300521.1 AY040226.1 
    BC009195.2 BC066656.1 X15187.1 

    Selected DOTS entries (see all 85):

    DT.65288659  DT.100891995  DT.95171177  DT.100891984  DT.91773982  DT.100891973  DT.100891987  DT.100891980 
    DT.91773968  DT.91838582  DT.100891989  DT.95171180  DT.100891999  DT.121182994  DT.91993952  DT.121182970 
    DT.95171374  DT.121182896  DT.100891975  DT.121182948  DT.121182963  DT.91940969  DT.121182707  DT.95171165 

    Selected AceView cDNA sequences (see all 1593):

    BM728967 BM972625 BM971669 AI719106 BM512519 BQ086292 BU159691 BU789024 
    CA393904 BP375148 BP358045 AA582283 AW455795 AU139214 BG681829 W45470 
    BQ710292 BU070402 AA315745 AA243082 BQ272378 BM769079 BI090575 BU078790 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90B1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
    SP1:                          -                 -                                                                                                     -     -   
    SP2:                          -                 -                                                                                                     -     -   
    SP3:                          -                 -           -     -     -     -     -     -     -     -     -     -                                             
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                        -   

    ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^ 21
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for HSP90B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSP90B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATAAAAA
    HSP90B1 Expression
    About this image


    HSP90B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HSP90B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192374
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90B1 (see all 7): 
              Cancer Drug Targets in human mouse rat
              Inflammasomes in human mouse rat
              Apoptosis 384HT in human mouse rat
              Unfolded Protein Response in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90B1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90b11 , 5 heat shock protein 90, beta (Grp94), member 11, 5 89.24(n)1
    96.01(a)1
      10 (43.05 cM)5
    220271  NM_011631.11  NP_035761.11 
     866902095 
    chicken
    (Gallus gallus)
    Aves HSP90B11 heat shock protein 90kDa beta (Grp94), member 1 81.36(n)
    90.05(a)
      374163  NM_204289.1  NP_989620.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSP90B16
    heat shock protein 90kDa beta (Grp94), member 1
    88(a)
    1 ↔ 1
    5(18171869-18181959)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684482 hypothetical protein MGC68448 78.16(n)    BC060352.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tra12 tumor rejection antigen (gp96) 1 76.5(n)   386590  BC063951.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gp931 Glycoprotein 93 60.14(n)
    61.92(a)
      43354  NM_143344.3  NP_651601.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_T05E11.31 CELE_T05E11.3 62.28(n)
    64.25(a)
      178014  NM_001268607.1  NP_001255536.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC826
    Cytoplasmic chaperone of the Hsp90 family, redunda...
    46(a)
    1 → many
    XIII(632355-634472) YMR186W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SHD1 SHD 58.64(n)
    53.09(a)
      828520  NM_202877.1  NP_974606.1 
    rice
    (Oryza sativa)
    Liliopsida Os.123932 Oryza sativa (japonica cultivar-group) mRNA for ferredoxin, more 71.4(n)    AK102478.1 


    ENSEMBL Gene Tree for HSP90B1 (if available)
    TreeFam Gene Tree for HSP90B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSP90B1 gene
    TRAP12  
    11 SIMAP similar genes for HSP90B1 using alignment to 5 protein entries:     ENPL_HUMAN (see all proteins):
    TRA1    GRP94c    HSP90AA2    HSP90AB1    HSP90AA1    HSP90AB4P
    HSP90B2P    EL52    HSP90AB3P    TRAP1    HSP90AA4P

    Find genes that share paralogs with HSP90B1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HSP90B1
    PGOHUM00000247287 PGOHUM00000244793


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSP90B1 (see all 403)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs115477241,2
    C,F--104326121(+) AAGTCG/AGAAAA 2 /S syn12Minor allele frequency- A:0.01NA EU 5847
    rs2011197821,2
    --104326149(+) AAGTTA/CACAGA 2 N H mis10--------
    rs1848579311,2
    --104326349(+) AGATAA/TCTGGG 1 -- int10--------
    rs2001415441,2
    --104326557(+) CTTAAC/TGCATC 1 -- int10--------
    rs2001392571,2
    C--104326578(+) TCTAAG/ATGTAT 1 -- int11Minor allele frequency- A:0.00EU 1323
    rs19467831,2
    H--104326800(+) ataggC/Atagat 1 -- int14Minor allele frequency- A:0.00NS EA 408
    rs1178869281,2
    C,F--104326862(+) AACTAT/CGGCCA 1 -- int11Minor allele frequency- C:0.15NA 120
    rs1896952761,2
    --104326878(+) AACTTG/TACTTG 1 -- int10--------
    rs743759891,2
    C--104326940(+) TGTGA-/CTGCTT 1 -- int10--------
    rs19204131,2
    C,F,A,H--104326991(+) CATAAG/ATCTCC 1 -- int115Minor allele frequency- A:0.38NA EA NS WA CSA 668

    HapMap Linkage Disequilibrium report for HSP90B1 (104323885 - 104347423 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSP90B1: --
    Human Gene Mutation Database (HGMD): HSP90B1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90B1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191175    OMIM disorders: --

    1 disease for HSP90B1:    
    About MalaCards
    globozoospermia

    1 disease from the University of Copenhagen DISEASES database for HSP90B1:
    Cancer

    Find genes that share disorders with HSP90B1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSP90B1 gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 67.4 46 11562776 (2), 9622079 (1), 15952740 (1), 9268304 (1) (see all 38)
    tumors 32.8 65 18331622 (6), 10797260 (5), 20400973 (2), 17278882 (2) (see all 35)
    cell damage 28.8 3 11113529 (2)
    cancer 26.6 26 16297569 (6), 14984057 (2), 15742415 (2), 10797260 (1) (see all 14)
    bipolar disorder 15.3 5 17805476 (4), 19125190 (1)
    solid tumor 14.7 1 10424404 (1)
    breast carcinoma 9.73 6 18190237 (2), 10424404 (2)
    colon cancer 5.01 9 15742415 (5), 10797260 (2)
    myeloma 2.9 2 15236592 (1), 18629835 (1)
    hepatocellular carcinoma 2.08 6 15069714 (2), 11335099 (1), 11229675 (1), 15810071 (1)

    Genetic Association Database (GAD): HSP90B1
    Human Genome Epidemiology (HuGE) Navigator: HSP90B1 (6 documents)

    Export disorders for HSP90B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSP90B1 gene, integrated from 10 sources (see all 425):
    (articles sorted by number of sources associating them with HSP90B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. (PubMed id 8617772)1, 7, 9 Chavany C....Neckers L. (J. Biol. Chem. 1996)
    2. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. (PubMed id 12475965)1, 2, 9 Meunier L.... Hendershot L.M. (Mol. Biol. Cell 2002)
    3. Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins. (PubMed id 2377606)1, 2, 9 Maki R.G.... Srivastava P.K. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1, 2 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD. (PubMed id 18264092)1, 2 Christianson J.C.... Kopito R.R. (Nat. Cell Biol. 2008)
    7. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    9. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 3 Chen B.... Monteiro A. (Genomics 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7184 HGNC: 12028 AceView: TRA1 Ensembl:ENSG00000166598 euGenes: HUgn7184
    ECgene: HSP90B1 Kegg: 7184 H-InvDB: HSP90B1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HSP90B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSP90B1 gene:
    Search GeneIP for patents involving HSP90B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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