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Aliases for HSP90B1 Gene

Aliases for HSP90B1 Gene

  • Heat Shock Protein 90 Beta Family Member 1 2 3
  • Heat Shock Protein 90kDa Beta (Grp94), Member 1 2 3
  • Heat Shock Protein 90kDa Beta Family Member 1 3 5
  • Heat Shock Protein 90 KDa Beta Member 1 3 4
  • Tumor Rejection Antigen (Gp96) 1 2 3
  • 94 KDa Glucose-Regulated Protein 3 4
  • Tumor Rejection Antigen 1 3 4
  • Endoplasmin 2 3
  • GRP94 3 4
  • TRA1 3 4
  • Epididymis Secretory Sperm Binding Protein Li 125m 3
  • Stress-Inducible Tumor Rejection Antigen Gp96 3
  • Endothelial Cell (HBMEC) Glycoprotein 3
  • Epididymis Luminal Protein 35 3
  • Gp96 Homolog 4
  • HEL-S-125m 3
  • GRP-94 4
  • HEL35 3
  • ECGP 3
  • GP96 3

External Ids for HSP90B1 Gene

Previous HGNC Symbols for HSP90B1 Gene

  • TRA1

Previous GeneCards Identifiers for HSP90B1 Gene

  • GC12P102848
  • GC12P104324
  • GC12P101383

Summaries for HSP90B1 Gene

Entrez Gene Summary for HSP90B1 Gene

  • This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

GeneCards Summary for HSP90B1 Gene

HSP90B1 (Heat Shock Protein 90 Beta Family Member 1) is a Protein Coding gene. Diseases associated with HSP90B1 include Oral Cavity Cancer and Bipolar Disorder. Among its related pathways are Pathways in cancer and Unfolded Protein Response (UPR). GO annotations related to this gene include calcium ion binding and unfolded protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot for HSP90B1 Gene

  • Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Gene Wiki entry for HSP90B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90B1 Gene

Genomics for HSP90B1 Gene

Regulatory Elements for HSP90B1 Gene

Enhancers for HSP90B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around HSP90B1 on UCSC Golden Path with GeneCards custom track

Promoters for HSP90B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for HSP90B1 Gene

Chromosome:
12
Start:
103,930,107 bp from pter
End:
103,953,645 bp from pter
Size:
23,539 bases
Orientation:
Plus strand

Genomic View for HSP90B1 Gene

Genes around HSP90B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90B1 Gene

Proteins for HSP90B1 Gene

  • Protein details for HSP90B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14625-ENPL_HUMAN
    Recommended name:
    Endoplasmin
    Protein Accession:
    P14625
    Secondary Accessions:
    • Q96A97

    Protein attributes for HSP90B1 Gene

    Size:
    803 amino acids
    Molecular mass:
    92469 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23.
    • Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23.

    Three dimensional structures from OCA and Proteopedia for HSP90B1 Gene

neXtProt entry for HSP90B1 Gene

Post-translational modifications for HSP90B1 Gene

  • Ubiquitination at Lys 75, Lys 142, Lys 168, Lys 270, Lys 434, and Lys 671
  • Glycosylation at Asn 62, Asn 107, Asn 217, Asn 445, Asn 481, and Asn 502
  • Modification sites at PhosphoSitePlus

Other Protein References for HSP90B1 Gene

No data available for DME Specific Peptides for HSP90B1 Gene

Domains & Families for HSP90B1 Gene

Gene Families for HSP90B1 Gene

Suggested Antigen Peptide Sequences for HSP90B1 Gene

Graphical View of Domain Structure for InterPro Entry

P14625

UniProtKB/Swiss-Prot:

ENPL_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90B1: view

Function for HSP90B1 Gene

Molecular function for HSP90B1 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Gene Ontology (GO) - Molecular Function for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 11958450
GO:0005509 calcium ion binding TAS 10497210
GO:0005515 protein binding IEA,IPI 9596688
GO:0005524 ATP binding IEA --
GO:0019903 protein phosphatase binding IDA 19000834
genes like me logo Genes that share ontologies with HSP90B1: view
genes like me logo Genes that share phenotypes with HSP90B1: view

Animal Models for HSP90B1 Gene

MGI Knock Outs for HSP90B1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90B1 Gene

Localization for HSP90B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90B1 Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90B1 Gene COMPARTMENTS Subcellular localization image for HSP90B1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
extracellular 5
nucleus 5
plasma membrane 3
golgi apparatus 2
mitochondrion 2
cytoskeleton 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum IEA,TAS 16130169
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IDA 10497210
genes like me logo Genes that share ontologies with HSP90B1: view

Pathways & Interactions for HSP90B1 Gene

genes like me logo Genes that share pathways with HSP90B1: view

Gene Ontology (GO) - Biological Process for HSP90B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 15620698
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0015031 protein transport NAS 15845869
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 18264092
genes like me logo Genes that share ontologies with HSP90B1: view

No data available for SIGNOR curated interactions for HSP90B1 Gene

Drugs & Compounds for HSP90B1 Gene

(41) Drugs for HSP90B1 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifabutin Approved Pharma Target, other/unknown 52
Geldanamycin Experimental Pharma Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0
Radicicol Experimental Pharma Target ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic 0
1-Methoxy-2-(2-Methoxyethoxy)Ethane Experimental Pharma Target 0
2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Experimental Pharma Target 0

(18) Additional Compounds for HSP90B1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(19) ApexBio Compounds for HSP90B1 Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
AT13387 Hsp90 inhibitor 912999-49-6
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
BIIB021 Hsp90 inhibitor,selective and competitive 848695-25-0
CH5138303 959763-06-5
Ganetespib (STA-9090) Hsp90 inhibitor,non-geldanamycin 888216-25-9
Geldanamycin Hsp90 inhibitor,potent and specific 30562-34-6
HSP990 (NVP-HSP990) 934343-74-5
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
NMS-E973 Hsp90 inhibitor,potent and selective 1253584-84-7
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-H71 Hsp90 inhibitor,potent and selective 873436-91-0
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
VER-49009 558640-51-0
VER-50589 747413-08-7
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90B1: view

Drug Products

Transcripts for HSP90B1 Gene

Unigene Clusters for HSP90B1 Gene

Heat shock protein 90kDa beta (Grp94), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90B1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a ·
SP1: - - - -
SP2: - - - -
SP3: - - - - - - - - - - - -
SP4: -
SP5: -
SP6:
SP7: - - - - -
SP8: -
SP9: - - - - - - - -
SP10:

ExUns: 17b ^ 18 ^ 19 ^ 20a · 20b · 20c · 20d ^ 21
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HSP90B1 Gene

GeneLoc Exon Structure for
HSP90B1
ECgene alternative splicing isoforms for
HSP90B1

Expression for HSP90B1 Gene

mRNA expression in normal human tissues for HSP90B1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSP90B1 Gene



Protein tissue co-expression partners for HSP90B1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSP90B1 Gene:

HSP90B1

SOURCE GeneReport for Unigene cluster for HSP90B1 Gene:

Hs.192374
genes like me logo Genes that share expression patterns with HSP90B1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90B1 Gene

Orthologs for HSP90B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSP90B1 34
  • 92.4 (n)
  • 97.88 (a)
HSP90B1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90B1 34
  • 92.78 (n)
  • 98.01 (a)
HSP90B1 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90b1 34
  • 89.24 (n)
  • 96.01 (a)
Hsp90b1 16
Hsp90b1 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSP90B1 34
  • 99.75 (n)
  • 99.88 (a)
HSP90B1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90b1 34
  • 89.15 (n)
  • 96.01 (a)
oppossum
(Monodelphis domestica)
Mammalia HSP90B1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90B1 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSP90B1 34
  • 81.36 (n)
  • 90.05 (a)
HSP90B1 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90B1 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90b1 34
  • 76.13 (n)
  • 85.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68448 34
zebrafish
(Danio rerio)
Actinopterygii hsp90b1 34
  • 75.45 (n)
  • 85.17 (a)
tra1 34
hsp90b1 35
  • 83 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13888 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001424 34
  • 59.91 (n)
  • 63.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gp93 34
  • 60.14 (n)
  • 61.92 (a)
Gp93 35
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_T05E11.3 34
  • 62.28 (n)
  • 64.25 (a)
enpl-1 35
  • 63 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 35
  • 46 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SHD 34
  • 58.64 (n)
  • 53.09 (a)
rice
(Oryza sativa)
Liliopsida Os.12393 34
Os06g0716700 34
  • 56.5 (n)
  • 52.26 (a)
corn
(Zea mays)
Liliopsida Zm.5048 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5238 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4613 35
  • 67 (a)
OneToOne
Species where no ortholog for HSP90B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSP90B1 Gene

ENSEMBL:
Gene Tree for HSP90B1 (if available)
TreeFam:
Gene Tree for HSP90B1 (if available)

Paralogs for HSP90B1 Gene

Paralogs for HSP90B1 Gene

Pseudogenes.org Pseudogenes for HSP90B1 Gene

genes like me logo Genes that share paralogs with HSP90B1: view

Variants for HSP90B1 Gene

Sequence variations from dbSNP and Humsavar for HSP90B1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1882019 -- 103,943,889(+) CTCGG(A/G)AAAGT intron-variant
rs1920413 -- 103,933,213(+) CATAA(A/G)TCTCC intron-variant
rs1946783 -- 103,933,022(+) atagg(A/C)tagat intron-variant
rs7313381 -- 103,948,026(+) AGTGA(C/T)TCAGG downstream-variant-500B
rs2033729 -- 103,934,929(+) ctccc(A/G)acctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSP90B1 Gene

Variant ID Type Subtype PubMed ID
esv3630621 CNV gain 21293372
nsv560039 CNV gain 21841781

Variation tolerance for HSP90B1 Gene

Residual Variation Intolerance Score: 5.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSP90B1 Gene

Human Gene Mutation Database (HGMD)
HSP90B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90B1 Gene

Disorders for HSP90B1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSP90B1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oral cavity cancer
  • malignant neoplasm of anterior portion of floor of mouth
bipolar disorder
  • bipolar depression
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HSP90B1

Genetic Association Database (GAD)
HSP90B1
Human Genome Epidemiology (HuGE) Navigator
HSP90B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSP90B1
genes like me logo Genes that share disorders with HSP90B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90B1 Gene

Publications for HSP90B1 Gene

  1. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3 4 65
  2. Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus. (PMID: 20351288) Bloor S. … Randow F. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 22 65
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 65
  4. Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1. (PMID: 19212831) Zhang L. … Wang Q. (Cancer Invest. 2009) 3 22 65
  5. Silencing of GRP94 expression promotes apoptosis in pancreatic cancer cells. (PMID: 19724918) Pan Z. … Kleeff J. (Int. J. Oncol. 2009) 3 22 65

Products for HSP90B1 Gene

Sources for HSP90B1 Gene

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