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HSP90AB4P Gene

pseudogene   GIFtS: 21
GCID: GC15M058983

Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 4,
Pseudogene1 2
HSP90Bd2

External Ids:    HGNC: 325381   Entrez Gene: 6646182   UniProtKB: Q58FF63   

Export aliases for HSP90AB4P gene to outside databases

Previous GC identifers: GC15M056770 GC15M035805


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSP90AB4P Gene:
HSP90AB4P (heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene) is a pseudogene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
regulation of specific target proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AB4P gene promoter:
         CUTL1   NF-AT   CREB   NF-AT2   POU2F1   POU2F1a   NF-AT3   SEF-1 (1)   STAT3   NF-AT1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AB4P


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.1   HGNC cytogenetic band: 15q21.3

HSP90AB4P Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AB4P gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M058983:  view genomic region     (about GC identifiers)

Start:
58,983,302 bp from pter      End:
58,985,324 bp from pter
Size:
2,023 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6 (See protein sequence)
Recommended Name: Putative heat shock protein HSP 90-beta 4  
Size: 505 amino acids; 58264 Da
Subunit: Homodimer (By similarity)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for HSP90AB4P: NX_Q58FF6

Explore proteomics data for HSP90AB4P at MOPED


See HSP90AB4P Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR001404 Hsp90_fam
 IPR020575 Hsp90_N
 IPR020568 Ribosomal_S5_D2-typ_fold
 IPR003594 HATPase_ATP-bd

Graphical View of Domain Structure for InterPro Entry Q58FF6

ProtoNet protein and cluster: Q58FF6

UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6
Similarity: Belongs to the heat shock protein 90 family


Find genes that share domains with HSP90AB4P           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: H90B4_HUMAN, Q58FF6
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
regulation of specific target proteins (By similarity)

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005524ATP binding IEA--
GO:0051082unfolded protein binding IEA--
     
Find genes that share ontologies with HSP90AB4P           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
H90B4_HUMAN, Q58FF6: Cytoplasm (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol3
nucleus2
cytoskeleton1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Interactions:

    Search GeneGlobe Interaction Network for HSP90AB4P

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006457protein folding IEA--
GO:0006950response to stress IEA--

Find genes that share ontologies with HSP90AB4P           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for HSP90AB4P (H90B4)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

HSP90AB4P Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HSP90AB4P Protein Expression
    Custom PCR Arrays for HSP90AB4P
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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  --

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HSP90AB4P gene
10 SIMAP similar genes for HSP90AB4P using alignment to 1 protein entry:     H90B4_HUMAN:
HSP90AA2    HSP90AB1    EL52    HSP90B1    HSP90AA1    HSP90AB3P
HSP90Af    HSP90AA5P    TRA1    HSP90AB2P

Find genes that share paralogs with HSP90AB4P           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HSP90AB4P (see all 122)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1816911111,2
--39043983(+) CAAAAA/TCTAGA 1 -- ds50010--------
rs1861222481,2
--39044043(+) AAGTAA/GTAAGA 1 -- ds50010--------
rs1410132751,2
C--39044087(+) TTCACC/TGCATT 1 -- ds50010--------
rs1908389951,2
--39044088(+) TCACCA/GCATTC 1 -- ds50010--------
rs1819795471,2
--39044112(+) GCCACA/GAAATC 1 -- ds50010--------
rs1851635871,2
--39044138(+) GAAAAA/CGCATC 1 -- ds50010--------
rs1907058271,2
--39044160(+) AGCACC/GTACTC 1 -- ds50010--------
rs124394571,2
C,F,A,H--39044161(+) GCACCC/TACTCA 1 -- ds500113Minor allele frequency- T:0.35NA WA CSA EA 377
rs1433448691,2
--39044207(+) ACTTCC/TTTAAC 1 -- ds50010--------
rs1467605501,2
C--39044213(+) TTAACC/GCGATA 1 -- ds50010--------

HapMap Linkage Disequilibrium report for HSP90AB4P (58983302 - 58985324 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for HSP90AB4P:    About this table    
Variant IDTypeSubtypePubMed ID
nsv904269CNV Loss21882294
esv34110CNV Loss18971310
nsv904254CNV Gain21882294
nsv7266OTHER Inversion18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HSP90AB4P gene integrated from 10 sources:
(articles sorted by number of sources associating them with HSP90AB4P)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (Genomics 2005)
  2. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
  3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  7. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 664618 HGNC: 32538 euGenes: HUgn664618 ECgene: HSP90AB4P H-InvDB: HSP90AB4P

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HSP90AB4P Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HSP90AB4P gene:
Search GeneIP for patents involving HSP90AB4P

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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