HSP90AB4P Gene
pseudogene GIFtS: 24
GCID: GC15M058983
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heat shock protein 90kDa alpha (cytosolic), class B member...
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Aliases
for HSP90AB4P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 2
| Aliases |
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| Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 4, Pseudogene1 2 | | HSP90Bd2 |
| External Ids: | HGNC: 325381 | Entrez Gene: 6646182 | UniProtKB: Q58FF63 | | ORGUL members: | |
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| NONCODE:n405691 | |
Export aliases for HSP90AB4P gene to outside databasesPrevious GC identifers: GC15M056770 GC15M035805
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Summaries
for HSP90AB4P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity)
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Genomic Views
for HSP90AB4P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSP90AB4P gene promoter:
CUTL1 NF-AT CREB NF-AT2 POU2F1 POU2F1a NF-AT3 SEF-1 (1) STAT3 NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSP90AB4P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB4P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.1 HGNC cytogenetic band: 15q21.3HSP90AB4P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M058983: view genomic region
(about GC identifiers)
Start:
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58,983,302 bp from pter |
End:
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58,985,324 bp from pter |
Size:
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2,023 bases |
Orientation:
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minus strand |
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Proteins
for HSP90AB4P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6 (See
protein sequence)Recommended Name: Putative heat shock protein HSP 90-beta 4 Size: 505 amino acids; 58264 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for HSP90AB4P: NX_Q58FF6
HSP90AB4P Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
HSP90AB4P for ontologies About GeneDecksing
HSP90AB4P Antibody Products:
Assay Products for HSP90AB4P: |
Protein
Domains /
Families
for HSP90AB4P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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HSP90AB4P for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q58FF6ProtoNet protein and cluster: Q58FF6 UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6Similarity: Belongs to the heat shock protein 90 family |
Function
for HSP90AB4P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: H90B4_HUMAN, Q58FF6Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB4P |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
HSP90AB4P for ontologies About GeneDecksing
|
Pathways & Interactions
for HSP90AB4P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSP90AB4P
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006457 | protein folding |
IEA | -- | | GO:0006950 | response to stress |
IEA | -- |
HSP90AB4P for ontologies About GeneDecksing
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Drugs & Compounds
for HSP90AB4P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for HSP90AB4P
Search CenterWatch for drugs/clinical trials and news about HSP90AB4P 
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Transcripts
for HSP90AB4P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for HSP90AB4P: Heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene Hs.670224 [show with all ESTs]Unigene Representative Sequence: NR_073415
Additional cDNA sequence: AY956765.1 NR_073415.1 1 DOTS entry: DT.75154104
GeneLoc Exon Structure
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Expression
for HSP90AB4P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
SOURCE GeneReport for Unigene cluster: Hs.670224
SABiosciences Custom PCR Arrays for HSP90AB4P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AB4P
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSP90AB4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB4P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB4P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB4P |
Orthologs
for HSP90AB4P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
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Paralogs
for HSP90AB4P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for HSP90AB4P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSP90AB4P
1 CNV: 47963 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HSP90AB4P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for HSP90AB4P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HSP90AB4P gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSP90AB4P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
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External Searches for HSP90AB4P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HSP90AB4P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HSP90AB4P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSP90AB4P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSP90AB4P | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HSP90AB4P gene:
Search GeneIP for patents involving HSP90AB4P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSP90AB4P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSP90AB4P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB4P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB4P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AB4P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB4P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB4P |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB4P |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB4P |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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