HSP90AB3P Gene
pseudogene GIFtS: 23
GCID: GC04P088812
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heat shock protein 90kDa alpha (cytosolic), class B member...(Previous names: heat shock 90kD protein 1, beta pseudogene 1, heat shock...)
(Previous symbol: HSPCP1)
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Aliases
for HSP90AB3P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 3, Pseudogene1 2 | | Heat Shock 90kDa Protein 1, Beta Pseudogene 11 | | HSPCP11 2 | | Heat Shock Protein 90-Beta C3 | | HSP90BC2 3 | | Heat Shock Protein 90Bc3 | | Heat Shock 90kD Protein 1, Beta Pseudogene 11 | | |
Export aliases for HSP90AB3P gene to outside databasesPrevious GC identifer: GC04P089031 |
Summaries
for HSP90AB3P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H90B3_HUMAN, Q58FF7Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity)
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Genomic Views
for HSP90AB3P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HSP90AB3P
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSP90AB3P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB3P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q22.1 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22.1HSP90AB3P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P088812: view genomic region
(about GC identifiers)
Start:
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88,812,911 bp from pter |
End:
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88,815,434 bp from pter |
Size:
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2,524 bases |
Orientation:
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plus strand |
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Proteins
for HSP90AB3P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: H90B3_HUMAN, Q58FF7 (See
protein sequence)Recommended Name: Putative heat shock protein HSP 90-beta-3 Size: 597 amino acids; 68325 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for HSP90AB3P: NX_Q58FF7
HSP90AB3P Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
HSP90AB3P for ontologies About GeneDecksing
HSP90AB3P Antibody Products:
Assay Products for HSP90AB3P: |
Protein
Domains /
Families
for HSP90AB3P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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HSP90AB3P for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q58FF7ProtoNet protein and cluster: Q58FF7 UniProtKB/Swiss-Prot: H90B3_HUMAN, Q58FF7Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins (By similarity)Similarity: Belongs to the heat shock protein 90 family |
Function
for HSP90AB3P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: H90B3_HUMAN, Q58FF7Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
HSP90AB3P for ontologies About GeneDecksing
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Pathways & Interactions
for HSP90AB3P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSP90AB3P
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006457 | protein folding |
IEA | -- | | GO:0006950 | response to stress |
IEA | -- |
HSP90AB3P for ontologies About GeneDecksing
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Drugs & Compounds
for HSP90AB3P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for HSP90AB3P
Search CenterWatch for drugs/clinical trials and news about HSP90AB3P 
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Transcripts
for HSP90AB3P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for HSP90AB3P: Heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene Hs.744112 [show with all ESTs]Unigene Representative Sequence: AY9567641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000505987
Additional cDNA sequence: AY956764.1 24/43 DOTS entries (see all 43): DT.95313805 DT.92408441 DT.92470997 DT.100725069 DT.121336150 DT.97869713 DT.100725038 DT.100804704 DT.91657672 DT.100725043 DT.100725010 DT.121336112 DT.121248411 DT.92326561 DT.121336180 DT.100725045 DT.95367855 DT.121336187 DT.91986763 DT.95367819 DT.100725015 DT.100725042 DT.121336080 DT.121336403 24/35 AceView cDNA sequences (see all 35): CR613228 CR606416 CR622516 CR616772 AI825134 AL135058 BU784211 AI589339 BQ376880 BI091590 AL121546 BU187927 BI493486 BE410994 BQ315693 CD624090 BE390504 BE737956 BQ376881 BE537536 AL515708 BF734306 AA085355 BQ329195
GeneLoc Exon Structure
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Expression
for HSP90AB3P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSP90AB3P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HSP90AB3P Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.744112
SABiosciences Custom PCR Arrays for HSP90AB3P
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSP90AB3P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB3P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB3P |
Orthologs
for HSP90AB3P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for HSP90AB3P gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Gm63685 |
predicted gene 6368 |
-- |
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X (62.74 cM) 141980175 |
ENSEMBL Gene Tree for HSP90AB3P (if available)
TreeFam Gene Tree for HSP90AB3P (if available) |
Paralogs
for HSP90AB3P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for HSP90AB3P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB3P |
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Disorders
/ Diseases
for HSP90AB3P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for HSP90AB3P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HSP90AB3P gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSP90AB3P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (2005)
- Assignment of an intron-containing human heat-shock protein gene (hsp90 beta, HSPCB) to chromosome 6 near TCTE1 (6p21) and two intronless pseudogenes to chromosomes 4 and 15 by polymerase chain reaction amplification from a panel of hybrid cell lines. (PubMed id 8288256)1, 3 Durkin A.S....Nierman W.C. (1993)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Shotgun proteomics and network analysis of ubiquitin-r elated proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (2012)
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1 Lingappa J.R....Goldstein D. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1 Rivadeneira F....Uitterlinden A.G. (2009)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
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External Searches for HSP90AB3P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HSP90AB3P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HSP90AB3P gene
(According to HUGE)
About This Section
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Specialized Databases showing HSP90AB3P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSP90AB3P | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HSP90AB3P gene:
Search GeneIP for patents involving HSP90AB3P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HSP90AB3P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSP90AB3P | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB3P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB3P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AB3P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB3P | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB3P |
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 | | | | |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB3P |
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