HSP90AB2P Gene
pseudogene GIFtS: 30
GCID: GC04P013335
|
|
heat shock protein 90kDa alpha (cytosolic), class B member...(Previous names: heat shock protein 90kDa alpha (cytosolic), class B member...)
| |
Aliases
for HSP90AB2P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 2, Pseudogene1 2 | | HSP90BB1 2 3 | | Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 2 (Pseudogene)1 | | Heat Shock Protein 90-Beta B3 | | Heat Shock Protein 90Bb3 |
| External Ids: | HGNC: 325371 | Entrez Gene: 3916342 | Ensembl: ENSG000002059407 | UniProtKB: Q58FF83 | | ORGUL members: | |
|---|
| NONCODE:n384422 | |
Export aliases for HSP90AB2P gene to outside databasesPrevious GC identifers: GC04P012945 GC04P012672
|---|
Summaries
for HSP90AB2P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: H90B2_HUMAN, Q58FF8Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity)
|
Genomic Views
for HSP90AB2P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSP90AB2P gene promoter:
c-Fos AP-1 CUTL1 Evi-1 S8 POU2F1 POU2F1a POU2F1b c-Jun POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSP90AB2P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB2P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.33 Ensembl cytogenetic band: 4p15.33 HGNC cytogenetic band: 4p15.33HSP90AB2P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P013335: view genomic region
(about GC identifiers)
Start:
|
13,335,037 bp from pter |
End:
|
13,340,281 bp from pter |
Size:
|
5,245 bases |
Orientation:
|
plus strand |
|
Proteins
for HSP90AB2P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: H90B2_HUMAN, Q58FF8 (See
protein sequence)Recommended Name: Putative heat shock protein HSP 90-beta 2 Size: 381 amino acids; 44349 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Despite classification as a pseudogene, the existence of this protein is supported by unambiguous massspectrometry evidence
Sequence caution: Sequence=AAX38250.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for HSP90AB2P: NX_Q58FF8
HSP90AB2P Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products for HSP90AB2P:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
HSP90AB2P for ontologies About GeneDecksing
HSP90AB2P Antibody Products:
Assay Products for HSP90AB2P: |
Protein
Domains /
Families
for HSP90AB2P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSP90AB2P for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q58FF8ProtoNet protein and cluster: Q58FF8 UniProtKB/Swiss-Prot: H90B2_HUMAN, Q58FF8Similarity: Belongs to the heat shock protein 90 family |
Function
for HSP90AB2P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: H90B2_HUMAN, Q58FF8Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation ofspecific target proteins (By similarity) Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0051082 | unfolded protein binding |
IEA | -- |
HSP90AB2P for ontologies About GeneDecksing
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB2P |
|
Pathways & Interactions
for HSP90AB2P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSP90AB2P
2 Interacting proteins for HSP90AB2P (Q58FF83) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | | GO:0006950 | response to stress |
IEA | -- |
HSP90AB2P for ontologies About GeneDecksing
|
Drugs & Compounds
for HSP90AB2P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSP90AB2P
Search CenterWatch for drugs/clinical trials and news about HSP90AB2P 
|
Transcripts
for HSP90AB2P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for HSP90AB2P: Heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene Hs.590925 [show with all ESTs]Unigene Representative Sequence: AY9567632 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507090(uc003gms.3) ENST00000382444
Additional cDNA sequence: AY956763.1 2 DOTS entries: DT.121252004 DT.97869717 1 AceView cDNA sequence: BP377047
GeneLoc Exon Structure
|
Expression
for HSP90AB2P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSP90AB2P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HSP90AB2P Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.590925
SABiosciences Custom PCR Arrays for HSP90AB2P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AB2P
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSP90AB2P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB2P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB2P |
Orthologs
for HSP90AB2P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for HSP90AB2P (if available)
TreeFam Gene Tree for HSP90AB2P (if available) |
Paralogs
for HSP90AB2P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HSP90AB2P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSP90AB2P (13335037 - 13340281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HSP90AB2P: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HSP90AB2P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSP90AB2P for disorders About GeneDecksing
1  disease for HSP90AB2P: About MalaCardsprostatitis
Export disorders for HSP90AB2P gene to outside databases
|
Publications
for HSP90AB2P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSP90AB2P gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with HSP90AB2P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Acetylation regulates gluconeogenesis by promoting PE PCK1 degradation via recruiting the UBR5 ubiquitin ligase. (PubMed id 21726808)1 Jiang W....Zhao S. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
|
External Searches for HSP90AB2P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSP90AB2P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSP90AB2P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSP90AB2P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSP90AB2P | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSP90AB2P gene:
Search GeneIP for patents involving HSP90AB2P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSP90AB2P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSP90AB2P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AB2P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AB2P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AB2P | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AB2P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AB2P |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB2P |
|  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB2P |
| |  | |
|
|
|
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 106 solr: 1.4
|
