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Aliases for HSP90AB2P Gene

Aliases for HSP90AB2P Gene

  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 2, Pseudogene 2 3
  • Heat Shock Protein 90Bb 3 4
  • HSP90BB 3 4
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 2 (Pseudogene) 2
  • Heat Shock Protein HSP 90-Beta 3
  • Heat Shock Protein 90-Beta B 4

External Ids for HSP90AB2P Gene

Previous GeneCards Identifiers for HSP90AB2P Gene

  • GC04P012945
  • GC04P012672

Summaries for HSP90AB2P Gene

GeneCards Summary for HSP90AB2P Gene

HSP90AB2P (Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 2, Pseudogene) is a Pseudogene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for HSP90AB2P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AB2P Gene

Genomics for HSP90AB2P Gene

Regulatory Elements for HSP90AB2P Gene

Genomic Location for HSP90AB2P Gene

Start:
13,333,414 bp from pter
End:
13,338,931 bp from pter
Size:
5,518 bases
Orientation:
Plus strand

Genomic View for HSP90AB2P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90AB2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AB2P Gene

Proteins for HSP90AB2P Gene

  • Protein details for HSP90AB2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58FF8-H90B2_HUMAN
    Recommended name:
    Putative heat shock protein HSP 90-beta 2
    Protein Accession:
    Q58FF8
    Secondary Accessions:

    Protein attributes for HSP90AB2P Gene

    Size:
    381 amino acids
    Molecular mass:
    44349 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAX38250.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HSP90AB2P Gene

Proteomics data for HSP90AB2P Gene at MOPED

Post-translational modifications for HSP90AB2P Gene

  • Ubiquitination at Lys53, Lys64, Lys69, Lys95, Lys141, Lys197, Lys206, Lys208, Lys304, and Lys332
  • Glycosylation at Asn46
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HSP90AB2P Gene

Domains for HSP90AB2P Gene

Protein Domains for HSP90AB2P Gene

Suggested Antigen Peptide Sequences for HSP90AB2P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q58FF8

UniProtKB/Swiss-Prot:

H90B2_HUMAN :
  • Q58FF8
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AB2P: view

No data available for Gene Families for HSP90AB2P Gene

Function for HSP90AB2P Gene

Molecular function for HSP90AB2P Gene

UniProtKB/Swiss-Prot Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Gene Ontology (GO) - Molecular Function for HSP90AB2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with HSP90AB2P: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSP90AB2P Gene

Localization for HSP90AB2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AB2P Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90AB2P Gene COMPARTMENTS Subcellular localization image for HSP90AB2P gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for HSP90AB2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HSP90AB2P: view

Pathways for HSP90AB2P Gene

SuperPathways for HSP90AB2P Gene

No Data Available

Interacting Proteins for HSP90AB2P Gene

Selected Interacting proteins: Q58FF8-H90B2_HUMAN for HSP90AB2P Gene via I2D

Symbol External ID(s) Details
MAP1LC3A
MAP1LC3B

Gene Ontology (GO) - Biological Process for HSP90AB2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006950 response to stress IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSP90AB2P: view

No data available for Pathways by source for HSP90AB2P Gene

Transcripts for HSP90AB2P Gene

mRNA/cDNA for HSP90AB2P Gene

(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSP90AB2P Gene

Heat shock protein 90kDa alpha (cytosolic), class B member 2, pseudogene:
Representative Sequences:

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSP90AB2P
    • Block miRNA regulation of HSP90AB2P using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for HSP90AB2P

    Primer Products

    • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HSP90AB2P
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB2P Gene

    No ASD Table

    Relevant External Links for HSP90AB2P Gene

    GeneLoc Exon Structure for
    HSP90AB2P
    ECgene alternative splicing isoforms for
    HSP90AB2P

    Expression for HSP90AB2P Gene

    mRNA expression in normal human tissues for HSP90AB2P Gene

    mRNA differential expression in normal tissues according to GTEx for HSP90AB2P Gene

    This gene is overexpressed in Heart - Left Ventricle (4.0).

    Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HSP90AB2P Gene

    SOURCE GeneReport for Unigene cluster for HSP90AB2P Gene Hs.590925

    genes like me logo Genes that share expressions with HSP90AB2P: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HSP90AB2P Gene

    Orthologs for HSP90AB2P Gene

    Evolution for HSP90AB2P Gene

    ENSEMBL:
    Gene Tree for HSP90AB2P (if available)
    TreeFam:
    Gene Tree for HSP90AB2P (if available)

    No data available for Orthologs for HSP90AB2P Gene

    Paralogs for HSP90AB2P Gene

    Selected SIMAP similar genes for HSP90AB2P Gene using alignment to 1 proteins:

    genes like me logo Genes that share paralogs with HSP90AB2P: view

    No data available for Paralogs for HSP90AB2P Gene

    Variants for HSP90AB2P Gene

    Structural Variations from Database of Genomic Variants (DGV) for HSP90AB2P Gene

    Variant ID Type Subtype PubMed ID
    nsv829866 CNV Loss 17160897
    nsv4238 CNV Insertion 18451855

    Relevant External Links for HSP90AB2P Gene

    HapMap Linkage Disequilibrium report
    HSP90AB2P

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HSP90AB2P Gene

    Disorders for HSP90AB2P Gene

    No disorders were found for HSP90AB2P Gene.

    No data available for UniProtKB/Swiss-Prot for HSP90AB2P Gene

    Publications for HSP90AB2P Gene

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 4
    2. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. (PMID: 16288044) Mahajan N.P. … Earp H.S. (Cancer Res. 2005) 3
    3. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. (PMID: 16507910) Uryu K. … Trojanowski J.Q. (Am. J. Pathol. 2006) 3
    4. The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. (PMID: 20811636) Giannone R.J. … Liu Y. (PLoS ONE 2010) 3
    5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

    Products for HSP90AB2P Gene

    • QIAGEN qRT-PCR Assays for microRNAs that regulate HSP90AB2P
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat
      • Predesigned siRNA for gene silencing in human,mouse,rat for HSP90AB2P
      • Block miRNA regulation of HSP90AB2P using miScript Target Protectors

      Sources for HSP90AB2P Gene

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