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HSP90AB1 Gene

protein-coding   GIFtS: 69
GCID: GC06P044214

Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member...

(Previous names: heat shock 90kD protein 1, beta, heat shock 90kDa protein...)
(Previous symbols: HSPC2, HSPCB)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 11 2     Heat Shock 90kDa Protein 1, Beta1
HSPC21 2 3 5     D6S1822
HSPCB1 2 3 5     HSP90-beta2
HSP90B2 3 5     Heat Shock Protein HSP 90-Beta2
Heat Shock 90kD Protein 1, Beta1 2     HSP 843
Heat Shock 84 KDa2 3     HSP 903
HSP842 3     

External Ids:    HGNC: 52581   Entrez Gene: 33262   Ensembl: ENSG000000963847   OMIM: 1405725   UniProtKB: P082383   

Export aliases for HSP90AB1 gene to outside databases

Previous GC identifers: GC06P044323 GC06P044324 GC06P043936


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSP90AB1 Gene:
This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal
transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive
form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and
inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on
multiple chromosomes. (provided by RefSeq, Dec 2012)

GeneCards Summary for HSP90AB1 Gene:
HSP90AB1 (heat shock protein 90kDa alpha (cytosolic), class B member 1) is a protein-coding gene. Diseases associated with HSP90AB1 include bronchitis, and laryngeal carcinoma. GO annotations related to this gene include unfolded protein binding and GTP binding. An important paralog of this gene is HSP90AA1.

UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AB1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AB1 gene promoter:
         NF-1   Elk-1   Sp1   p300   Lmo2   YY1   Egr-4   MZF-1   CP2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): HSP90AB1 promoter sequence
   Search Chromatin IP Primers for HSP90AB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12

HSP90AB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P044214:  view genomic region     (about GC identifiers)

Start:
44,214,824 bp from pter      End:
44,221,620 bp from pter
Size:
6,797 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-beta  
Size: 724 amino acids; 83264 Da
Subunit: Homodimer. Interacts with p53/TP53 (By similarity). Forms a complex with CDK6 and Hsp90/HSP90AB1.
Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1
and DNAJC7 (By similarity). Interacts with FKBP4
Sequence caution: Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAB66478.1; Type=Frameshift; Positions=709;
4 PDB 3D structures from and Proteopedia for HSP90AB1:
1QZ2 (3D)        1UYM (3D)        3NMQ (3D)        3PRY (3D)    
Secondary accessions: B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6

Explore the universe of human proteins at neXtProt for HSP90AB1: NX_P08238

Explore proteomics data for HSP90AB1 at MOPED

Post-translational modifications: 

  • Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro)1
  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity (Probable)1
  • Ubiquitination2 at Lys53, Lys64, Lys69, Lys95, Lys107, Lys180, Lys186, Lys204, Lys219, Lys275,
                                 Lys284, Lys286, Lys306, Lys319, Lys354, Lys399, Lys411, Lys428, Lys435, Lys438 (see all 30)
  • Glycosylation2 at Asn46, Ser434, Ser452
  • Modification sites at PhosphoSitePlus

  • See HSP90AB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001258898.1  NP_001258899.1  NP_001258900.1  NP_001258901.1  NP_031381.2  

    ENSEMBL proteins: 
     ENSP00000360709   ENSP00000325875   ENSP00000360609  
    Reactome Protein details: P08238

    HSP90AB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for HSP90AB1
    OriGene Purified Protein for HSP90AB1
    OriGene Protein Over-expression Lysate for HSP90AB1
    OriGene MassSpec for HSP90AB1
    OriGene Custom Protein Services for HSP90AB1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AB1
    Novus Biologicals HSP90AB1 Proteins
    Novus Biologicals HSP90AB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSP90AB1
    Browse Proteins at Cloud-Clone Corp.

    HSP90AB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AB1
    R&D Systems Antibodies for HSP90AB1 (HSP90 beta)
    Cell Signaling Technology (CST) Antibodies for HSP90AB1  (HSP90B)
    OriGene Antibodies for HSP90AB1
    OriGene Custom Antibody Services for HSP90AB1
    Novus Biologicals HSP90AB1 Antibodies
    Abcam antibodies for HSP90AB1 (P08238, P07900)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HSP90AB1
    LSBio Antibodies in human, mouse, rat for HSP90AB1

    HSP90AB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90AB1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for HSP90AB1 (HSP90 beta)
    GenScript Custom Assay Services for HSP90AB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P08238

    ProtoNet protein and cluster: P08238

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90B_HUMAN, P08238
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins (By similarity)
    Similarity: Belongs to the heat shock protein 90 family


    HSP90AB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90B_HUMAN, P08238
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): Selected molecular function terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002134UTP binding IEA--
    GO:0002135CTP binding IEA--
    GO:0003725double-stranded RNA binding IDA--
    GO:0005515protein binding IPI11036079
    GO:0005524ATP binding IEA--
         
    HSP90AB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSP90AB1:
     Increased cell death HMECs cel 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hsp90ab1):
     cardiovascular system  cellular  embryogenesis  mortality/aging 

    HSP90AB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSP90AB1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSP90AB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSP90AB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSP90AB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSP90AB1:
    hsa-mir-186-5p (MIRT044926), hsa-mir-501-5p (MIRT041138), hsa-mir-615-3p (MIRT039893), hsa-mir-193b-3p (MIRT016366), hsa-mir-484 (MIRT041702), hsa-mir-296-3p (MIRT038357), hsa-mir-15b-5p (MIRT046508), hsa-mir-877-3p (MIRT037004), hsa-mir-455-3p (MIRT037860), hsa-mir-181d-5p (MIRT041164), hsa-mir-92a-3p (MIRT049288), hsa-mir-93-3p (MIRT038803), hsa-mir-320a (MIRT044757)

    Block miRNA regulation of human, mouse, rat HSP90AB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HSP90AB1:
    hsa-miR-589* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSP90AB1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSP90AB1

    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90AB1 (see all 7)
    OriGene ORF clones in mouse, rat for HSP90AB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSP90AB1 (NM_007355)
    Sino Biological Human cDNA Clone for HSP90AB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AB1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSP90AB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HS90B_HUMAN, P08238: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    nucleus2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--
    GO:0008180colocalizes with COP9 signalosome IDA18850735

    HSP90AB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSP90AB1 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    Inflammasomes0.00
    NOD-like receptor signaling pathway0.37
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    4Semaphorin interactions
    Semaphorin interactions0.43
    Sema3A PAK dependent Axon repulsion0.00
    5Mechanisms of CFTR activation by S nitrosoglutathione normal and CF
    CFTR folding and maturation norm and CF 0.37
    Mechanisms of CFTR activation by S nitrosoglutathione normal and CF 0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSP90AB1
        Apoptosis Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for HSP90AB1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AB1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSP90AB1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    2 BioSystems Pathways for HSP90AB1
        TNF-alpha/NF-kB Signaling Pathway
    Integrated Pancreatic Cancer Pathway


    Selected Reactome Pathways for HSP90AB1 (see all 6)
        HSF1-dependent transactivation
    Regulation of actin dynamics for phagocytic cup formation
    The NLRP3 inflammasome
    Sema3A PAK dependent Axon repulsion
    HSF1 activation


    Selected Kegg Pathways  (Kegg details for HSP90AB1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation


    HSP90AB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AB1 (see all 146): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HSP90AB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90AB1 (P082381, 2, 3 ENSP000003258754) via UniProtKB, MINT, STRING, and/or I2D (see all 1303)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3, ENSP000003753994MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000375399
    ENSG00000215328P081072, 3, ENSP000003829154MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000382915
    ENSG00000224501P081072, 3, ENSP000003753914MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000375391
    ENSG00000231555P081072, 3, ENSP000004035304MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000403530
    ENSG00000232804P081072, 3, ENSP000003930874MINT-72641 MINT-8378890 MINT-8086576 I2D: score=4 STRING: ENSP00000393087
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001890placenta development IEA--
    GO:0006457protein folding IEA--
    GO:0006950response to stress ----
    GO:0006986response to unfolded protein NAS2768249
    GO:0007411axon guidance TAS--

    HSP90AB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AB1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AB1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    Selected DrugBank Compounds for HSP90AB1 (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423 10592235
    Geldanamycin-- 30562-34-6target--17139284 17016423 10592235
    (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE-- --target--10592235
    (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE-- --target--10592235
    (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE-- --target--10592235
    (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE-- --target--10592235
    2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE-- --target--10592235
    4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL-- --target--10592235
    4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90AB1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 73.6 5 15141013 (4), 16979135 (1)
    17-(allylamino)-17-demethoxygeldanamycin 66.1 1 17409432 (1)
    calpeptin 58 1 10601241 (1)
    steroid 30.1 4 1537818 (2), 2365084 (1)
    glycerol 13.3 2 2365084 (1), 9480920 (1)
    estrogen 7.15 3 1890971 (1), 7883750 (1), 2243115 (1)
    estradiol 4.02 2 2365084 (1), 1491008 (1)
    dexamethasone 1.86 2 8991187 (1), 1279841 (1)
    polyacrylamide 0 1 9480920 (1)
    oligonucleotide 0 8 8991187 (3)



    HSP90AB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for HSP90AB1 gene (5 alternative transcripts): 
    NM_001271969.1  NM_001271970.1  NM_001271971.1  NM_001271972.1  NM_007355.3  

    Unigene Cluster for HSP90AB1:

    Heat shock protein 90kDa alpha (cytosolic), class B member 1
    Hs.509736  [show with all ESTs]
    Unigene Representative Sequence: NM_001271969
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371646(uc003oxa.1 uc011dvr.1 uc011dvs.1 uc003oxc.1)
    ENST00000353801(uc003oxb.1) ENST00000371554

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      QuantiFast Probe-based Assays in human, mouse, rat HSP90AB1

    Additional mRNA sequence: 

    AF275719.1 AK025370.1 AK130494.1 AK290734.1 AK294643.1 AK297367.1 AK312255.1 AL136543.1 
    AY359878.1 BC004928.1 BC007327.2 BC009206.2 BC012807.2 BC014485.1 BC016753.2 BC068474.1 
    BX649079.1 D28342.1 M16660.1 

    Selected DOTS entries (see all 173):

    DT.95313805  DT.92408441  DT.92470997  DT.121336150  DT.100725038  DT.92326561  DT.100725015  DT.91902593 
    DT.92411584  DT.121336080  DT.95139876  DT.121336390  DT.121336180  DT.100652561  DT.100725069  DT.121336358 
    DT.100804704  DT.121336274  DT.100725071  DT.97869713  DT.91657672  DT.100724999  DT.100725012  DT.121336112 

    Selected AceView cDNA sequences (see all 219):

    T51115 AA487401 AW963867 BI494859 T59996 T59827 AA075646 AA101959 
    BM014574 AA487283 H50320 T59691 T51023 AA075645 CA398011 AA287134 
    AW675427 BM875458 AI094312 AA211753 AI874069 AW439011 AA284704 AI364752 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                                                                                                                    -                                       
    SP2:                                                                                                                    -                                       
    SP3:                                                                                                                    -                                       
    SP4:                          -                             -                                                                                                   
    SP5:                                                                                                  -     -                                                   

    ExUns: 16b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for HSP90AB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSP90AB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCCCACT
    HSP90AB1 Expression
    About this image


    HSP90AB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    HSP90AB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509736
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AB1 (see all 146): 
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Wound Healing in human mouse rat
              Prostate Cancer in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AB1 gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90ab11 , 5 heat shock protein 90 alpha (cytosolic), class B member more1, 5 89.69(n)1
    99.59(a)1
      17 (22.59 cM)5
    155161  NM_008302.31  NP_032328.21 
     455677755 
    chicken
    (Gallus gallus)
    Aves HSP90AB11 heat shock protein 90kDa alpha (cytosolic), class B more 81.54(n)
    94.2(a)
      396188  NM_206959.1  NP_996842.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSP90AB16
    heat shock protein 90kDa alpha (cytosolic), class ...
    94(a)
    1 ↔ 1
    1(227915054-227933305)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.293532 Xenopus laevis transcribed sequence with moderate similarity more 82.14(n)    BU914717.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF042108.12   -- 80.33(n)   30573  AF042108.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp831 Heat shock protein 83 71.78(n)
    78.48(a)
      38389  NM_001274433.1  NP_001261362.1 
    worm
    (Caenorhabditis elegans)
    Secernentea daf-211 daf-21 70.95(n)
    78.18(a)
      179971  NM_074225.3  NP_506626.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSP821 HSP82 60.53(n)
    62.48(a)
      855836   NP_015084.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP90.11 HSP90.1 65.8(n)
    70.95(a)
      835341  NM_124642.3  NP_200076.1 
    rice
    (Oryza sativa)
    Liliopsida AB111810.12   -- 74.36(n)    AB111810.1 


    ENSEMBL Gene Tree for HSP90AB1 (if available)
    TreeFam Gene Tree for HSP90AB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSP90AB1 gene
    HSP90AA12  
    14 SIMAP similar genes for HSP90AB1 using alignment to 3 protein entries:     HS90B_HUMAN (see all proteins):
    EL52    HSP90Bf    HSP90AA1    HSP90AA2    HSP90AB3P    HSP90AB4P
    HSP90AA4P    HSP90B1    GRP94c    HSP90AA5P    TRA1    HSP90AB2P
    HSP90B2P    TRAP1

    HSP90AB1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for HSP90AB1 (see all 13)
    PGOHUM00000238347 PGOHUM00000248469 PGOHUM00000258861 PGOHUM00000234979 PGOHUM00000240431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSP90AB1 (see all 383)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs624038671,2
    C,F--44211921(+) TGGTCC/GTAAGA 1 -- us2k14Minor allele frequency- G:0.20NA WA 242
    rs1821745171,2
    C--44211960(+) GCCTCC/TGCGGC 1 -- us2k10--------
    rs754979061,2
    C,F--44212018(+) GGGTTA/GAGGGC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs737338861,2
    C,F--44212035(+) TCCTGT/CGTATG 1 -- us2k15Minor allele frequency- C:0.08WA CSA NA EA 362
    rs1495184651,2
    C--44212103(+) GAAAAC/GGATGG 1 -- us2k10--------
    rs122162161,2
    C,F--44212152(+) CCTGGA/GAGAGA 1 -- us2k1 trp32Minor allele frequency- G:0.15NA EA 240
    rs351369391,2
    C--44212170(+) ATTTC-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1460442201,2
    --44212246(+) GCTCAC/TGGCAA 1 -- us2k10--------
    rs1876520731,2
    C--44212247(+) CTCACA/GGCAAC 1 -- us2k10--------
    rs3241281,2
    C,F,A--44212311(-) CGCCTG/ATAGTC 1 -- us2k18Minor allele frequency- A:0.42WA NA CSA EA 368

    HapMap Linkage Disequilibrium report for HSP90AB1 (44214824 - 44221620 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HSP90AB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5282CNV Insertion18451855
    nsv462936CNV Loss19166990
    nsv524398CNV Loss19592680
    nsv885851CNV Loss21882294
    nsv885852CNV Loss21882294
    dgv6843n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): HSP90AB1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90AB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140572    OMIM disorders: --

    Selected diseases for HSP90AB1 (see all 49):    
    About MalaCards
    bronchitis    laryngeal carcinoma    glucocorticoid resistance    laryngitis
    rheumatic disease    myasthenia gravis    gastrointestinal stromal tumor    dermatomyositis
    uveitis    mantle cell lymphoma    lupus erythematosus    asthma
    acute leukemia    cystic fibrosis    myopathy    huntington's disease
    multiple myeloma    insulin resistance    myeloma    nasopharyngitis


    HSP90AB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for HSP90AB1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 78.2 58 1988296 (3), 20353823 (3), 14532285 (3), 8991187 (2) (see all 41)
    laryngeal carcinoma 31.7 3 11717891 (2), 10920983 (1)
    laryngeal cancer 26.7 1 10920983 (1)
    lupus erythematosus systemic 22.6 2 11771959 (1), 8216691 (1)
    bronchitis chronic 21.7 1 11775547 (1)
    breast cancer 5.54 4 10638971 (1), 10376793 (1), 9364934 (1), 1312348 (1)
    asthma 0 1 11775547 (1)
    tumors 0 2 19576239 (2)
    carcinoma 0 4 18497978 (1), 8878452 (1)
    melanoma 0 1 7954339 (1)

    Genetic Association Database (GAD): HSP90AB1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AB1 (6 documents)

    Export disorders for HSP90AB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSP90AB1 gene, integrated from 10 sources (see all 290):
    (articles sorted by number of sources associating them with HSP90AB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PubMed id 2768249)1, 2, 3 Rebbe N.F.... Hickman S. (J. Biol. Chem. 1989)
    2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 3, 9 Chen B.... Monteiro A. (Genomics 2005)
    3. A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta). (PubMed id 8180474)1, 2, 9 Takahashi I.... Hashimoto K. (Mamm. Genome 1994)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    6. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)
    7. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3326 HGNC: 5258 AceView: HSPCB.1 Ensembl:ENSG00000096384 euGenes: HUgn3326
    ECgene: HSP90AB1 Kegg: 3326 H-InvDB: HSP90AB1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HSP90AB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSP90AB1 gene:
    Search GeneIP for patents involving HSP90AB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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