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Aliases for HSP90AB1 Gene

Aliases for HSP90AB1 Gene

  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1 2 3
  • HSP90B 3 4 6
  • HSPC2 3 4 6
  • HSPCB 3 4 6
  • Heat Shock 90kD Protein 1, Beta 2 3
  • Heat Shock 84 KDa 3 4
  • HSP84 3 4
  • Heat Shock 90kDa Protein 1, Beta 2
  • Heat Shock Protein HSP 90-Beta 3
  • HSP90-Beta 3
  • D6S182 3
  • HSP 84 4
  • HSP 90 4

External Ids for HSP90AB1 Gene

Previous HGNC Symbols for HSP90AB1 Gene

  • HSPC2
  • HSPCB

Previous GeneCards Identifiers for HSP90AB1 Gene

  • GC06P044323
  • GC06P044324
  • GC06P044214
  • GC06P043936

Summaries for HSP90AB1 Gene

Entrez Gene Summary for HSP90AB1 Gene

  • This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]

GeneCards Summary for HSP90AB1 Gene

HSP90AB1 (Heat Shock Protein 90kDa Alpha (Cytosolic), Class B Member 1) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Pathways in cancer. GO annotations related to this gene include GTP binding and unfolded protein binding. An important paralog of this gene is HSP90AA1.

UniProtKB/Swiss-Prot for HSP90AB1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Tocris Summary for HSP90AB1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic proteins.

Gene Wiki entry for HSP90AB1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AB1 Gene

Genomics for HSP90AB1 Gene

Regulatory Elements for HSP90AB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSP90AB1 Gene

Start:
44,246,166 bp from pter
End:
44,253,888 bp from pter
Size:
7,723 bases
Orientation:
Plus strand

Genomic View for HSP90AB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90AB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AB1 Gene

Proteins for HSP90AB1 Gene

  • Protein details for HSP90AB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08238-HS90B_HUMAN
    Recommended name:
    Heat shock protein HSP 90-beta
    Protein Accession:
    P08238
    Secondary Accessions:
    • B2R5P0
    • Q5T9W7
    • Q9NQW0
    • Q9NTK6

    Protein attributes for HSP90AB1 Gene

    Size:
    724 amino acids
    Molecular mass:
    83264 Da
    Quaternary structure:
    • Homodimer. Interacts with p53/TP53 (By similarity). Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7 (By similarity). Interacts with FKBP4. May interact with NWD1 (PubMed:24681825).
    SequenceCaution:
    • Sequence=AAD14062.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66478.1; Type=Frameshift; Positions=709; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HSP90AB1 Gene

neXtProt entry for HSP90AB1 Gene

Proteomics data for HSP90AB1 Gene at MOPED

Post-translational modifications for HSP90AB1 Gene

  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity.
  • Ubiquitinated in the presence of STUB1-UBE2D1 complex (in vitro).
  • Ubiquitination at Lys53, Lys64, Lys69, Lys95, Lys107, Lys180, Lys186, Lys204, Lys219, Lys275, Lys284, Lys286, Lys306, Lys319, Lys354, Lys399, Lys411, Lys428, Lys435, Lys438, Lys481, Lys491, Lys505, Lys531, Lys538, Lys559, Lys565, Lys607, Lys623, and Lys624
  • Glycosylation at Asn46, Ser434, and Ser452
  • Modification sites at PhosphoSitePlus

Other Protein References for HSP90AB1 Gene

Antibody Products

  • R&D Systems Antibodies for HSP90AB1 (HSP90 beta)
  • Cell Signaling Technology (CST) Antibodies for HSP90AB1 (HSP90B)

No data available for DME Specific Peptides for HSP90AB1 Gene

Domains for HSP90AB1 Gene

Gene Families for HSP90AB1 Gene

HGNC:
  • HSPC :Heat shock proteins / HSPC

Graphical View of Domain Structure for InterPro Entry

P08238

UniProtKB/Swiss-Prot:

HS90B_HUMAN :
  • P08238
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AB1: view

Function for HSP90AB1 Gene

Molecular function for HSP90AB1 Gene

UniProtKB/Swiss-Prot Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Gene Ontology (GO) - Molecular Function for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002134 UTP binding --
GO:0002135 CTP binding --
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0005515 protein binding IPI 11036079
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HSP90AB1: view

Phenotypes for HSP90AB1 Gene

genes like me logo Genes that share phenotypes with HSP90AB1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSP90AB1 Gene

Localization for HSP90AB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90AB1 Gene COMPARTMENTS Subcellular localization image for HSP90AB1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 20833797
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HSP90AB1: view

Pathways for HSP90AB1 Gene

genes like me logo Genes that share pathways with HSP90AB1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat
    • Allergy & Asthma in human,mouse,rat
    • Alzheimers Disease in human,mouse,rat
    • Amino Acid Metabolism I in human,mouse,rat

Gene Ontology (GO) - Biological Process for HSP90AB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001890 placenta development IEA --
GO:0006457 protein folding IEA --
GO:0006950 response to stress --
GO:0006986 response to unfolded protein NAS 2768249
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with HSP90AB1: view

Compounds for HSP90AB1 Gene

(5) Tocris Compounds for HSP90AB1 Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor [75747-14-7]
Gedunin Hsp90 inhibitor; exhibits anticancer and antimalarial activity [2753-30-2]
Geldanamycin Selective Hsp90 inhibitor [30562-34-6]
PU H71 Potent Hsp90 inhibitor [873436-91-0]
Radicicol Hsp90 inhibitor. Antifungal antibiotic [12772-57-5]

(19) ApexBio Compounds for HSP90AB1 Gene

Compound Action Cas Number
17-AAG (KOS953) ansamycin antibiotic which acts as an anti-tumor agent [75747-14-7]
17-AAG Hydrochloride binds to Hsp90 and alters its function. [911710-03-7]
17-DMAG (Alvespimycin) HCl potent HSP90 inhibitor [467214-21-7]
Alvespimycin selective Hsp90 inhibitor [467214-20-6]
AT13387 non-geldanamycin HPS90 [912999-49-6]
AUY922 (NVP-AUY922) potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90 [747412-49-3]
BIIB021 oral fully synthetic Hsp90 inhibitor. [848695-25-0]
Ganetespib (STA-9090) potent small-molecule inhibitor of Hsp90 [888216-25-9]
IPI-504 (Retaspimycin hydrochloride) selective inhibitor of Hsp90 [857402-63-2]
KW-2478 novel and potent nonansamycin inhibitor of Hsp90 [819812-04-9]
MPC-3100 orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 [958025-66-6]
NVP-BEP800 binds to the NH2-terminal ATP-binding pocket of Hsp90. [847559-80-2]
PF-04929113 (SNX-5422) orally bioavailable Hsp90 inhibitor. [908115-27-5]
PU-H71 potent Hsp90 inhibitor [873436-91-0]
Radicicol potent inhibitor of Hsp90, SRC, and Cox-2 [12772-57-5]
Retaspimycin small-molecule inhibitor of HSP90 [857402-23-4]
SNX-2112 Hsp90 inhibitor [908112-43-6]
VER 155008 potent inhibitor of Hsp70 family of chaperones [1134156-31-2]
XL-888 novel and orally-bioavailable inhibitor of HSP90 [1149705-71-4]

(13) Novoseek inferred chemical compound relationships for HSP90AB1 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 73.6 5
17-(allylamino)-17-demethoxygeldanamycin 66.1 1
calpeptin 58 1
steroid 30.1 3
glycerol 13.3 2
genes like me logo Genes that share compounds with HSP90AB1: view

Transcripts for HSP90AB1 Gene

Unigene Clusters for HSP90AB1 Gene

Heat shock protein 90kDa alpha (cytosolic), class B member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AB1 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
SP1: -
SP2: -
SP3: -
SP4: - -
SP5: - -
SP6: -
SP7: - - - - - - - - - - - - - - - -
SP8:
SP9: - - - -
SP10:
SP11: -
SP12:

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HSP90AB1 Gene

GeneLoc Exon Structure for
HSP90AB1
ECgene alternative splicing isoforms for
HSP90AB1

Expression for HSP90AB1 Gene

mRNA expression in normal human tissues for HSP90AB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90AB1 Gene

SOURCE GeneReport for Unigene cluster for HSP90AB1 Gene Hs.509736

genes like me logo Genes that share expressions with HSP90AB1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90AB1 Gene

Orthologs for HSP90AB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSP90AB1 35
  • 99.54 (n)
  • 99.86 (a)
HSP90AB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSP90AB1 35
  • 90.84 (n)
  • 99.59 (a)
HSP90AB1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90AB1 35
  • 91.39 (n)
  • 99.86 (a)
SLC29A1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90ab1 35
  • 89.69 (n)
  • 99.59 (a)
Hsp90ab1 16
Hsp90ab1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSP90AB1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90AB1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90ab1 35
  • 89.83 (n)
  • 99.59 (a)
chicken
(Gallus gallus)
Aves HSP90AB1 35
  • 81.54 (n)
  • 94.2 (a)
HSP90AB1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90AB1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.29353 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90ab1 35
  • 80.73 (n)
  • 92.81 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1282 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
hsp90ab1 35
  • 79.89 (n)
  • 91.7 (a)
hsp90ab1 36
  • 90 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta HSP83_ANOGA 35
  • 71.78 (n)
  • 80.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsp83 35
  • 71.78 (n)
  • 78.48 (a)
Hsp83 36
  • 79 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-21 35
  • 70.95 (n)
  • 78.18 (a)
daf-21 36
  • 77 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL148C 35
  • 61.82 (n)
  • 62.82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP82 35
  • 60.53 (n)
  • 62.48 (a)
HSP82 36
  • 62 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12958g 35
  • 60.59 (n)
  • 63.53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP90.1 35
  • 65.8 (n)
  • 70.95 (a)
rice
(Oryza sativa)
Liliopsida Os08g0500700 35
  • 68.09 (n)
  • 69.66 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.217 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04142 35
  • 67.48 (n)
  • 67.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hsp90 35
  • 62.7 (n)
  • 64.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11103 36
  • 78 (a)
OneToMany
Species with no ortholog for HSP90AB1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HSP90AB1 Gene

ENSEMBL:
Gene Tree for HSP90AB1 (if available)
TreeFam:
Gene Tree for HSP90AB1 (if available)

Paralogs for HSP90AB1 Gene

Paralogs for HSP90AB1 Gene

Selected SIMAP similar genes for HSP90AB1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSP90AB1: view

Variants for HSP90AB1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13296 -- 44,250,383(-) TTGGG(C/T)TTTTC reference, synonymous-codon
rs324128 -- 44,244,574(-) CGCCT(A/G)TAGTC upstream-variant-2KB
rs324129 -- 44,244,759(-) actcc(A/G)tctca upstream-variant-2KB
rs324130 -- 44,244,951(-) AGTTC(A/G)CAACC upstream-variant-2KB
rs324131 -- 44,246,956(-) AAAAA(A/G)GAGGG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSP90AB1 Gene

Variant ID Type Subtype PubMed ID
nsv885851 CNV Loss 21882294
nsv5282 CNV Insertion 18451855
nsv885852 CNV Loss 21882294
nsv462936 CNV Loss 19166990
dgv6843n71 CNV Loss 21882294
nsv524398 CNV Loss 19592680

Relevant External Links for HSP90AB1 Gene

HapMap Linkage Disequilibrium report
HSP90AB1
Human Gene Mutation Database (HGMD)
HSP90AB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AB1 Gene

Disorders for HSP90AB1 Gene

(11) Novoseek inferred disease relationships for HSP90AB1 Gene

Disease -log(P) Hits PubMed IDs
shock 78.2 51
laryngeal carcinoma 31.7 3
laryngeal cancer 26.7 1
lupus erythematosus systemic 22.6 2
bronchitis chronic 21.7 1

Relevant External Links for HSP90AB1

Genetic Association Database (GAD)
HSP90AB1
Human Genome Epidemiology (HuGE) Navigator
HSP90AB1
genes like me logo Genes that share disorders with HSP90AB1: view

No data available for UniProtKB/Swiss-Prot for HSP90AB1 Gene

Publications for HSP90AB1 Gene

  1. A cosmid clone at the D6S182 locus on human chromosome 6p12 contains the 90-kDa heat shock protein beta gene (HSP90 beta). (PMID: 8180474) Takahashi I. … Hashimoto K. (Mamm. Genome 1994) 3 4 23
  2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 23
  3. Nucleotide sequence and regulation of a human 90-kDa heat shock protein gene. (PMID: 2768249) Rebbe N.F. … Hickman S. (J. Biol. Chem. 1989) 2 3 4
  4. Nucleotide sequence of a cDNA for a member of the human 90-kDa heat- shock protein family. (PMID: 3301534) Rebbe N.F. … Stafford D.W. (Gene 1987) 3 4
  5. A two-dimensional gel database of human colon carcinoma proteins. (PMID: 9150948) Ji H. … Simpson R.J. (Electrophoresis 1997) 3 4

Products for HSP90AB1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Adherens Junctions in human,mouse,rat
    • Adipogenesis in human,mouse,rat
    • Allergy & Asthma in human,mouse,rat
    • Alzheimers Disease in human,mouse,rat
    • Amino Acid Metabolism I in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HSP90AB1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HSP90AB1
  • Block miRNA regulation of HSP90AB1 using miScript Target Protectors

Sources for HSP90AB1 Gene

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