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Aliases for HSP90AA2P Gene

Aliases for HSP90AA2P Gene

  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2, Pseudogene 2 3
  • HSP90AA2 3 4 6
  • HSPCAL3 3 4 6
  • Heat Shock 90kDa Protein 1, Alpha-Like 3 2 3
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 Pseudogene 3
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2 2
  • Heat Shock Protein HSP 90-Alpha A2 Pseudogene 4
  • Heat Shock 90 KDa Protein 1 Alpha-Like 3 4
  • Heat Shock 90kD Protein 1, Alpha-Like 3 2
  • Heat Shock 90kD Protein, Alpha-Like 3 3
  • Heat Shock Protein 86 3
  • HSP90ALPHA 3
  • HSPCA 3

External Ids for HSP90AA2P Gene

Previous Symbols for HSP90AA2P Gene

  • HSPCAL3
  • HSP90AA2

Summaries for HSP90AA2P Gene

Entrez Gene Summary for HSP90AA2P Gene

  • HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]

GeneCards Summary for HSP90AA2P Gene

HSP90AA2P (Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2, Pseudogene) is a Pseudogene. Among its related pathways are MAPK Pathway.

UniProtKB/Swiss-Prot for HSP90AA2P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Tocris Summary for HSP90AA2P Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic proteins.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA2P Gene

Genomics for HSP90AA2P Gene

Genomic Location for HSP90AA2P Gene

Start:
27,888,171 bp from pter
End:
27,891,092 bp from pter
Size:
2,922 bases
Orientation:
Minus strand

Genomic View for HSP90AA2P Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90AA2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA2P Gene

No data available for Regulatory Elements for HSP90AA2P Gene

Proteins for HSP90AA2P Gene

  • Protein details for HSP90AA2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14568-HS902_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha A2
    Protein Accession:
    Q14568
    Secondary Accessions:

    Protein attributes for HSP90AA2P Gene

    Size:
    343 amino acids
    Molecular mass:
    39365 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSP90AA2P Gene

Proteomics data for HSP90AA2P Gene at MOPED

Post-translational modifications for HSP90AA2P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSP90AA2P Gene

Domains for HSP90AA2P Gene

UniProtKB/Swiss-Prot:

HS902_HUMAN
Family:
  • Belongs to the heat shock protein 90 family.:
    • Q14568
genes like me logo Genes that share domains with HSP90AA2P: view

No data available for Gene Families for HSP90AA2P Gene

Function for HSP90AA2P Gene

Molecular function for HSP90AA2P Gene

UniProtKB/Swiss-Prot Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Gene Ontology (GO) - Molecular Function for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005524 ATP binding IEA --
GO:0051082 unfolded protein binding IEA --
genes like me logo Genes that share ontologies with HSP90AA2P: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSP90AA2P Gene

Localization for HSP90AA2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA2P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HSP90AA2P: view

Pathways for HSP90AA2P Gene

SuperPathways for HSP90AA2P Gene

Superpath Contained pathways
1 MAPK Pathway
genes like me logo Genes that share pathways with HSP90AA2P: view

Pathways by source for HSP90AA2P Gene

1 Tocris pathway for HSP90AA2P Gene

Interacting Proteins for HSP90AA2P Gene

Selected Interacting proteins: Q14568-HS902_HUMAN for HSP90AA2P Gene via I2D

Symbol External ID(s) Details
GABARAP
GABARAPL1
--
  • Q6FG91 21

Gene Ontology (GO) - Biological Process for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0006950 response to stress IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HSP90AA2P: view

Compounds for HSP90AA2P Gene

(5) Tocris Compounds for HSP90AA2P Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor [75747-14-7]
Gedunin Hsp90 inhibitor; exhibits anticancer and antimalarial activity [2753-30-2]
Geldanamycin Selective Hsp90 inhibitor [30562-34-6]
PU H71 Potent Hsp90 inhibitor [873436-91-0]
Radicicol Hsp90 inhibitor. Antifungal antibiotic [12772-57-5]

(1) Novoseek inferred chemical compound relationships for HSP90AA2P Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 76.3 5
genes like me logo Genes that share compounds with HSP90AA2P: view

Transcripts for HSP90AA2P Gene

mRNA/cDNA for HSP90AA2P Gene

(1) REFSEQ mRNAs :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA2P Gene

No ASD Table

Relevant External Links for HSP90AA2P Gene

GeneLoc Exon Structure for
HSP90AA2P
ECgene alternative splicing isoforms for
HSP90AA2P

Expression for HSP90AA2P Gene

mRNA expression in normal human tissues for HSP90AA2P Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HSP90AA2P Gene

genes like me logo Genes that share expressions with HSP90AA2P: view

Orthologs for HSP90AA2P Gene

Evolution for HSP90AA2P Gene

ENSEMBL:
Gene Tree for HSP90AA2P (if available)
TreeFam:
Gene Tree for HSP90AA2P (if available)

No data available for Orthologs for HSP90AA2P Gene

Paralogs for HSP90AA2P Gene

No data available for Paralogs for HSP90AA2P Gene

Variants for HSP90AA2P Gene

Relevant External Links for HSP90AA2P Gene

HapMap Linkage Disequilibrium report
HSP90AA2P

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HSP90AA2P Gene

Disorders for HSP90AA2P Gene

(4) Novoseek inferred disease relationships for HSP90AA2P Gene

Disease -log(P) Hits PubMed IDs
shock 65.6 21
cancer 26 9
breast cancer 2.93 2
tumors 0 7
genes like me logo Genes that share disorders with HSP90AA2P: view

No data available for UniProtKB/Swiss-Prot for HSP90AA2P Gene

Publications for HSP90AA2P Gene

  1. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PMID: 1740332) Ozawa K. … Yokoyama K. (Genomics 1992) 2 3 4
  2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 4
  3. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. (PMID: 18559531) Yang Y. … Bhalla K. (Cancer Res. 2008) 3 23
  4. Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene. (PMID: 2591742) Walter T. … Benecke B.J.J. (Gene 1989) 3 4
  5. Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90. (PMID: 19130193) Kobayakawa T. … Nemoto T.K. (Protein J. 2009) 3 23

Products for HSP90AA2P Gene

Sources for HSP90AA2P Gene

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