Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HSP90AA2P Gene

Aliases for HSP90AA2P Gene

  • Heat Shock Protein 90kDa Alpha Family Class A Member 2, Pseudogene 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2, Pseudogene 2 3
  • Heat Shock 90kDa Protein 1, Alpha-Like 3 2 3
  • HSP90AA2 3 4
  • HSPCAL3 3 4
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 Pseudogene 3
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 2 2
  • Heat Shock Protein HSP 90-Alpha A2 Pseudogene 4
  • Heat Shock 90 KDa Protein 1 Alpha-Like 3 4
  • Heat Shock 90kD Protein 1, Alpha-Like 3 2
  • Heat Shock 90kD Protein, Alpha-Like 3 3
  • Heat Shock Protein 86 3
  • HSP90ALPHA 3
  • HSPCA 3

External Ids for HSP90AA2P Gene

Previous HGNC Symbols for HSP90AA2P Gene

  • HSPCAL3
  • HSP90AA2

Summaries for HSP90AA2P Gene

Entrez Gene Summary for HSP90AA2P Gene

  • HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.[supplied by OMIM, Aug 2008]

GeneCards Summary for HSP90AA2P Gene

HSP90AA2P (Heat Shock Protein 90kDa Alpha Family Class A Member 2, Pseudogene) is a Pseudogene. Among its related pathways are MAPK Pathway. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot for HSP90AA2P Gene

  • Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA2P Gene

Genomics for HSP90AA2P Gene

Regulatory Elements for HSP90AA2P Gene

Enhancers for HSP90AA2P Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSP90AA2P on UCSC Golden Path with GeneCards custom track

Promoters for HSP90AA2P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSP90AA2P on UCSC Golden Path with GeneCards custom track

Genomic Location for HSP90AA2P Gene

Chromosome:
11
Start:
27,888,171 bp from pter
End:
27,891,092 bp from pter
Size:
2,922 bases
Orientation:
Minus strand

Genomic View for HSP90AA2P Gene

Genes around HSP90AA2P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AA2P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AA2P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA2P Gene

Proteins for HSP90AA2P Gene

  • Protein details for HSP90AA2P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14568-HS902_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha A2
    Protein Accession:
    Q14568

    Protein attributes for HSP90AA2P Gene

    Size:
    343 amino acids
    Molecular mass:
    39365 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for HSP90AA2P Gene

Proteomics data for HSP90AA2P Gene at MOPED

Post-translational modifications for HSP90AA2P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSP90AA2P Gene

Domains & Families for HSP90AA2P Gene

Suggested Antigen Peptide Sequences for HSP90AA2P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14568

UniProtKB/Swiss-Prot:

HS902_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA2P: view

No data available for Gene Families for HSP90AA2P Gene

Function for HSP90AA2P Gene

Molecular function for HSP90AA2P Gene

UniProtKB/Swiss-Prot Function:
Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins.

Gene Ontology (GO) - Molecular Function for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HSP90AA2P: view

Phenotypes for HSP90AA2P Gene

GenomeRNAi human phenotypes for HSP90AA2P:
genes like me logo Genes that share phenotypes with HSP90AA2P: view

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSP90AA2P Gene

Localization for HSP90AA2P Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA2P Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSP90AA2P: view

No data available for Subcellular locations from COMPARTMENTS for HSP90AA2P Gene

Pathways & Interactions for HSP90AA2P Gene

SuperPathways for HSP90AA2P Gene

Superpath Contained pathways
1 MAPK Pathway
genes like me logo Genes that share pathways with HSP90AA2P: view

Pathways by source for HSP90AA2P Gene

1 Tocris pathway for HSP90AA2P Gene

Interacting Proteins for HSP90AA2P Gene

Selected Interacting proteins: Q14568-HS902_HUMAN for HSP90AA2P Gene via I2D

Gene Ontology (GO) - Biological Process for HSP90AA2P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with HSP90AA2P: view

No data available for SIGNOR curated interactions for HSP90AA2P Gene

Drugs & Compounds for HSP90AA2P Gene

(19) Drugs for HSP90AA2P Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Geldanamycin Experimental Pharma Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0
Radicicol Experimental Pharma Hsp90 inhibitor. Antifungal antibiotic 0
17-AAG (KOS953) Pharma Hsp90 inhibitor 0
17-DMAG (Alvespimycin) HCl Pharma Hsp90 inhibitor 0
AUY922 (NVP-AUY922) Pharma Potent Hsp90 inhibitor 0

(2) Additional Compounds for HSP90AA2P Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
CCT 018159
171009-07-7

(5) Tocris Compounds for HSP90AA2P Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor 75747-14-7
CCT 018159 Hsp90 inhibitor 171009-07-7
Geldanamycin Selective Hsp90 inhibitor 30562-34-6
Herbimycin A Src family kinase inhibitor. Also Hsp90 inhibitor 70563-58-5
Radicicol Hsp90 inhibitor. Antifungal antibiotic 12772-57-5

(10) ApexBio Compounds for HSP90AA2P Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-H71 Hsp90 inhibitor,potent and selective 873436-91-0
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90AA2P: view

Transcripts for HSP90AA2P Gene

mRNA/cDNA for HSP90AA2P Gene

(1) REFSEQ mRNAs :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA2P Gene

No ASD Table

Relevant External Links for HSP90AA2P Gene

GeneLoc Exon Structure for
HSP90AA2P
ECgene alternative splicing isoforms for
HSP90AA2P

Expression for HSP90AA2P Gene

mRNA expression in normal human tissues for HSP90AA2P Gene

Protein differential expression in normal tissues from HIPED for HSP90AA2P Gene

This gene is overexpressed in Cervix (43.0) and Lavage (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSP90AA2P Gene



genes like me logo Genes that share expression patterns with HSP90AA2P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HSP90AA2P Gene

Orthologs for HSP90AA2P Gene

Evolution for HSP90AA2P Gene

ENSEMBL:
Gene Tree for HSP90AA2P (if available)
TreeFam:
Gene Tree for HSP90AA2P (if available)

No data available for Orthologs for HSP90AA2P Gene

Paralogs for HSP90AA2P Gene

No data available for Paralogs for HSP90AA2P Gene

Variants for HSP90AA2P Gene

Sequence variations from dbSNP and Humsavar for HSP90AA2P Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_039732 -
VAR_039733 -

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for HSP90AA2P Gene

Disorders for HSP90AA2P Gene

Relevant External Links for HSP90AA2P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSP90AA2P

No disorders were found for HSP90AA2P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSP90AA2P Gene

Publications for HSP90AA2P Gene

  1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 4 67
  2. Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90. (PMID: 19130193) Kobayakawa T. … Nemoto T.K. (Protein J. 2009) 3 23
  3. The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors. (PMID: 17724475) Ammirante M. … Turco M.C. (Oncogene 2008) 3 23
  4. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. (PMID: 18559531) Yang Y. … Bhalla K. (Cancer Res. 2008) 3 23
  5. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PMID: 1740332) Ozawa K. … Yokoyama K. (Genomics 1992) 2 3

Products for HSP90AA2P Gene

Sources for HSP90AA2P Gene

Content