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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90AA2 Gene

pseudogene   GIFtS: 33
GCID: GC11M027866

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha-like 3, heat shock 90kDa...)
(Previous symbol: HSPCAL3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 21 2     HSP90ALPHA2
HSPCAL31 2 3 5     HSPCA2
Heat Shock 90kD Protein 1, Alpha-Like 31     Heat Shock 90 KDa Protein 1 Alpha-Like 33
Heat Shock 90kDa Protein 1, Alpha-Like 31     

External Ids:    HGNC: 52561   Entrez Gene: 33242   Ensembl: ENSG000002244117   OMIM: 1405755   UniProtKB: Q145683   

Export aliases for HSP90AA2 gene to outside databases

Previous GC identifer: GC11M027607


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA2 Gene:
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein
folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other
cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding
denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in
endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 (PubMed
16269234)). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.(supplied by OMIM, Aug 2008)

GeneCards Summary for HSP90AA2 Gene: 
HSP90AA2 (heat shock protein 90kDa alpha (cytosolic), class A member 2) is a pseudogene. Diseases associated with HSP90AA2 include nasopharyngitis, and hypoxia, and among its related super-pathways are Toll-like Receptor Pathway. GO annotations related to this gene include unfolded protein binding and ATP binding.

UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
regulation of specific target proteins (By similarity)

summary for HSP90AA2 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HSP90AA2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HSP90AA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.2-p14.1

HSP90AA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M027866:  view genomic region     (about GC identifiers)

Start:
27,909,718 bp from pter      End:
27,912,639 bp from pter
Size:
2,922 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568 (See protein sequence)
Recommended Name: Putative heat shock protein HSP 90-alpha A2  
Size: 343 amino acids; 39365 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cytoplasm (By similarity)
Caution: Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass
spectrometry evidence

Explore the universe of human proteins at neXtProt for HSP90AA2: NX_Q14568

Explore proteomics data for HSP90AA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14568

  • HSP90AA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSP90AA2 Protein Expression

    Human Recombinant Protein Products for HSP90AA2: 
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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    HSP90AA2 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry Q14568

    ProtoNet protein and cluster: Q14568

    1 Blocks protein domain: IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568
    Similarity: Belongs to the heat shock protein 90 family


    HSP90AA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS902_HUMAN, Q14568
    Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
    regulation of specific target proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    HSP90AA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSP90AA2 
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    Cell Line
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSP90AA2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Toll-like Receptor Pathway
    MAPK Pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for HSP90AA2
        MAPK Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSP90AA2

    3 Interacting proteins for HSP90AA2 (Q145683) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPO951663I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    --Q6FG913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006950response to stress IEA--

    HSP90AA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90AA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HSP90AA2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    1 Novoseek inferred chemical compound relationship for HSP90AA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 76.3 10 15296636 (3), 15358769 (1), 16118214 (1)

    Search CenterWatch for drugs/clinical trials and news about HSP90AA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSP90AA2 gene: 
    NM_001040141.1  

    Unigene Cluster for HSP90AA2:

    Heat shock protein 90kDa alpha (cytosolic), class A member 2
    Hs.523560  [show with all ESTs]
    Unigene Representative Sequence: M30627
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530115 ENST00000440936
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript Custom all cDNA clones Services for HSP90AA2
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA2
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    Additional mRNA sequence: M30627.1 

    24/43 DOTS entries (see all 43):

    DT.100849252  DT.100730427  DT.97848122  DT.120782168  DT.92061474  DT.98131982  DT.91781494  DT.95129185 
    DT.100857433  DT.100730476  DT.100801571  DT.100730448  DT.100730410  DT.100860129  DT.91845523  DT.100680135 
    DT.100730481  DT.100846879  DT.100658316  DT.120781649  DT.100730420  DT.91875478  DT.95378122  DT.100730406 

    24/61 AceView cDNA sequences (see all 61):

    M30627 BI227434 AA130903 BG031245 CD110594 BG705523 AW328133 AA074972 
    BM757429 BF680319 BX450797 BU069116 AW118519 CA867140 T64700 BX326347 
    BX347177 AA148354 BQ304592 T88770 BE208258 BX433783 AI827443 BQ312092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSP90AA2 Expression
    About this image


    See HSP90AA2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.523560
        SABiosciences Custom PCR Arrays for HSP90AA2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for HSP90AA2 (if available)
    TreeFam Gene Tree for HSP90AA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90AA2 gene
    11 SIMAP similar genes for HSP90AA2 using alignment to 1 protein entry:     HS902_HUMAN:
    EL52    HSP90AA4P    HSP90AA1    HSP90AA5P    HSP90AB4P    HSP90AB1
    HSP90B1    HSP90AB3P    TRA1    HSP90AB2P    TRAP1

    HSP90AA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in HSP90AA2 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0397334
    ----see VAR_0397332 C Y mis40--------
    VAR_0397324
    ----see VAR_0397322 T A mis40--------

    HapMap Linkage Disequilibrium report for HSP90AA2 (27909718 - 27912639 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSP90AA2: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HSP90AA2
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140575    OMIM disorders: --

    12 diseases for HSP90AA2:    About MalaCards
    nasopharyngitis    hypoxia    cataract    glioblastoma
    hepatitis b    breast cancer    gastric cancer    retinitis
    colorectal cancer    endotheliitis    hepatitis    leukemia


    HSP90AA2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HSP90AA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 65.6 26 17427945 (5), 15562767 (3), 10037161 (2), 15191408 (1) (see all 14)
    cancer 26 11 14606110 (3), 18497978 (1), 8878452 (1), 20138026 (1) (see all 7)
    breast cancer 2.93 2 10376793 (2)
    tumors 0 7 18559531 (4), 19576239 (2), 18781898 (1)

    Genetic Association Database (GAD): HSP90AA2

    Export disorders for HSP90AA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA2 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with HSP90AA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (2005)
    2. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PubMed id 1740332)1, 2, 3 Ozawa K....Yokoyama K. (1992)
    3. Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene. (PubMed id 2591742)1, 2 Walter T.... Benecke B.J.J. (1989)
    4. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. (PubMed id 18559531)1, 9 Yang Y....Bhalla K. (2008)
    5. Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90. (PubMed id 19130193)1, 9 Kobayakawa T....Nemoto T.K. (2009)
    6. The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors. (PubMed id 17724475)1, 9 Ammirante M....Turco M.C. (2008)
    7. Differential expression of HSP90a and heme oxygenase i n cord blood RBC during preeclampsia. (PubMed id 22935040)1 Ekambaram P....Dhakshinamoorthy L. (2013)
    8. Heat shock protein 90 (Hsp90) selectively regulates th e stability of KDM4B/JMJD2B histone demethylase. (PubMed id 23589305)1 Ipenberg I....Ayoub N. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Heat shock protein 90a (HSP90a), a substrate and chape rone of DNA-PK necessary for the apoptotic response. (PubMed id 22753480)1 Solier S....Pommier Y. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3324 HGNC: 5256 AceView: HSPCAL3 Ensembl:ENSG00000224411 euGenes: HUgn3324
    ECgene: HSP90AA2 H-InvDB: HSP90AA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90AA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSP90AA2 gene:
    Search GeneIP for patents involving HSP90AA2

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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