Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HSP90AA2 Gene

pseudogene   GIFtS: 34
GCID: GC11M027866

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha-like 3, heat shock 90kDa...)
(Previous symbol: HSPCAL3)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 21 2     HSP90ALPHA2
HSPCAL31 2 3 5     HSPCA2
Heat Shock 90kD Protein 1, Alpha-Like 31     Heat Shock 90 KDa Protein 1 Alpha-Like 33
Heat Shock 90kDa Protein 1, Alpha-Like 31     

External Ids:    HGNC: 52561   Entrez Gene: 33242   Ensembl: ENSG000002244117   OMIM: 1405755   UniProtKB: Q145683   

Export aliases for HSP90AA2 gene to outside databases

Previous GC identifer: GC11M027607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HSP90AA2 Gene:
HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein
folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other
cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding
denatured proteins after stress. HSP90AA2 is a cytosolic HSP90 protein. Other HSP90 proteins are found in
endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 (PubMed
16269234)). See HSP90AA1 (MIM 140571) for further information on HSP90 proteins.(supplied by OMIM, Aug 2008)

GeneCards Summary for HSP90AA2 Gene:
HSP90AA2 (heat shock protein 90kDa alpha (cytosolic), class A member 2) is a pseudogene. GO annotations related to this gene include unfolded protein binding.

UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568
Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
regulation of specific target proteins (By similarity)

summary for HSP90AA2 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HSP90AA2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HSP90AA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.2-p14.1

HSP90AA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M027866:  view genomic region     (about GC identifiers)

Start:
27,909,718 bp from pter      End:
27,912,639 bp from pter
Size:
2,922 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568 (See protein sequence)
Recommended Name: Putative heat shock protein HSP 90-alpha A2  
Size: 343 amino acids; 39365 Da
Subunit: Homodimer (By similarity)
Caution: Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass
spectrometry evidence

Explore the universe of human proteins at neXtProt for HSP90AA2: NX_Q14568

Explore proteomics data for HSP90AA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys74, Lys112, Lys153, Lys185, Lys282, Lys291, Lys293
  • Modification sites at PhosphoSitePlus

  • See HSP90AA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    HSP90AA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HSP90AA2
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSP90AA2 

     
    antibodies-online proteins for HSP90AA2 (3 products) 

     
    antibodies-online peptides for HSP90AA2

    HSP90AA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSP90AA2
    Search for Antibodies for HSP90AA2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for HSP90AA2
    antibodies-online antibodies for HSP90AA2 (62 products) 

    HSP90AA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90AA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSP90AA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSP90AA2 
    antibodies-online kits for HSP90AA2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry Q14568

    ProtoNet protein and cluster: Q14568

    1 Blocks protein domain: IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: HS902_HUMAN, Q14568
    Similarity: Belongs to the heat shock protein 90 family


    Find genes that share domains with HSP90AA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS902_HUMAN, Q14568
    Function: Putative molecular chaperone that may promote the maturation, structural maintenance and proper
    regulation of specific target proteins (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with HSP90AA2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HSP90AA2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HSP90AA2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSP90AA2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSP90AA2
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSP90AA2

    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HSP90AA2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSP90AA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HS902_HUMAN, Q14568: Cytoplasm (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with HSP90AA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HSP90AA2 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK Pathway
    MAPK Pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Tocris Bioscience Pathway for HSP90AA2
        MAPK Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSP90AA2
    Interactions:

        Search GeneGlobe Interaction Network for HSP90AA2

    3 Interacting proteins for HSP90AA2 (Q145683) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPO951663I2D: score=1 
    GABARAPL1Q9H0R83I2D: score=1 
    --Q6FG913I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0006950response to stress IEA--

    Find genes that share ontologies with HSP90AA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AA2 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AA2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    1 Novoseek inferred chemical compound relationship for HSP90AA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 76.3 10 15296636 (3), 15358769 (1), 16118214 (1)



    Find genes that share compounds with HSP90AA2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HSP90AA2 gene: 
    NM_001040141.1  

    Unigene Cluster for HSP90AA2:

    Heat shock protein 90kDa alpha (cytosolic), class A member 2
    Hs.523560  [show with all ESTs]
    Unigene Representative Sequence: M30627
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530115 ENST00000440936
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSP90AA2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSP90AA2
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSP90AA2
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA2
    Clone
    Products:
         
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HSP90AA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HSP90AA2
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA2
      QuantiFast Probe-based Assays in human, mouse, rat HSP90AA2

    Additional mRNA sequence: M30627.1 

    Selected DOTS entries (see all 43):

    DT.100849252  DT.100730427  DT.97848122  DT.120782168  DT.92061474  DT.98131982  DT.91781494  DT.95129185 
    DT.100857433  DT.100730476  DT.100801571  DT.100730448  DT.100730410  DT.100860129  DT.91845523  DT.100680135 
    DT.100730481  DT.100846879  DT.100658316  DT.120781649  DT.100730420  DT.91875478  DT.95378122  DT.100730406 

    Selected AceView cDNA sequences (see all 61):

    M30627 BI227434 AA130903 CD110594 BG031245 AW328133 AA074972 BM757429 
    BF680319 AW118519 BG705523 BU069116 CA867140 BX450797 BX347177 BX326347 
    AA148354 BQ304592 T64700 BF979827 BE208258 AI827443 T88770 BX433783 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HSP90AA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSP90AA2 Expression
    About this image


    HSP90AA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    HSP90AA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523560
        Custom PCR Arrays for HSP90AA2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HSP90AA2
    QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA2
    QuantiFast Probe-based Assays in human, mouse, rat HSP90AA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
      --

    ENSEMBL Gene Tree for HSP90AA2 (if available)
    TreeFam Gene Tree for HSP90AA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HSP90AA2 gene
    11 SIMAP similar genes for HSP90AA2 using alignment to 1 protein entry:     HS902_HUMAN:
    EL52    HSP90AA4P    HSP90AA1    HSP90AA5P    HSP90AB4P    HSP90AB1
    HSP90B1    HSP90AB3P    TRA1    HSP90AB2P    TRAP1

    Find genes that share paralogs with HSP90AA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for HSP90AA2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27268361,2,4
    ----see VAR_0397332 mis40--------
    rs18263301,2,4
    ----see VAR_0397322 mis40--------

    HapMap Linkage Disequilibrium report for HSP90AA2 (27909718 - 27912639 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HSP90AA2: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HSP90AA2
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 140575    OMIM disorders: --


    Find genes that share disorders with HSP90AA2           About GenesLikeMe

    4 Novoseek inferred disease relationships for HSP90AA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 65.6 26 17427945 (5), 15562767 (3), 10037161 (2), 15191408 (1) (see all 14)
    cancer 26 11 14606110 (3), 18497978 (1), 8878452 (1), 20138026 (1) (see all 7)
    breast cancer 2.93 2 10376793 (2)
    tumors 0 7 18559531 (4), 19576239 (2), 18781898 (1)

    Genetic Association Database (GAD): HSP90AA2

    Export disorders for HSP90AA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HSP90AA2 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with HSP90AA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3 Chen B.... Monteiro A. (Genomics 2005)
    2. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PubMed id 1740332)1, 2, 3 Ozawa K.... Yokoyama K. (Genomics 1992)
    3. Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene. (PubMed id 2591742)1, 2 Walter T.... Benecke B.J.J. (Gene 1989)
    4. Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. (PubMed id 18559531)1, 9 Yang Y....Bhalla K. (Cancer Res. 2008)
    5. Single nucleotide polymorphism that accompanies a missense mutation (Gln488His) impedes the dimerization of Hsp90. (PubMed id 19130193)1, 9 Kobayakawa T....Nemoto T.K. (Protein J. 2009)
    6. The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors. (PubMed id 17724475)1, 9 Ammirante M....Turco M.C. (Oncogene 2008)
    7. Differential expression of HSP90I+ and heme oxygenase in cord blood RBC during preeclampsia. (PubMed id 22935040)1 Ekambaram P....Dhakshinamoorthy L. (Toxicol. Mech. Methods 2013)
    8. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. (PubMed id 23589305)1 Ipenberg I....Ayoub N. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Heat shock protein 90I+ (HSP90I+), a substrate and chaperone of DNA-PK necessary for the apoptotic response. (PubMed id 22753480)1 Solier S....Pommier Y. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3324 HGNC: 5256 AceView: HSPCAL3 Ensembl:ENSG00000224411 euGenes: HUgn3324
    ECgene: HSP90AA2 H-InvDB: HSP90AA2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HSP90AA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HSP90AA2 gene:
    Search GeneIP for patents involving HSP90AA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HSP90AA2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   Browse OriGene clones  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSP90AA2   OriGene Custom Protein Services for HSP90AA2  

     
     
     Block miRNA regulation of human, mouse, rat HSP90AA2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HSP90AA2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA2 Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA2
     QuantiFast Probe-based Assays in human, mouse, rat HSP90AA2 QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA2
     Custom PCR Arrays for HSP90AA2 Search Chromatin IP Primers for HSP90AA2
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HSP90AA2  Search GeneGlobe Interaction Network for HSP90AA2
     Search Regulatory tfbs for HSP90AA2
     GenScript Custom Purified and Recombinant Proteins Services for HSP90AA2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HSP90AA2
     GenScript Custom Assay Services for HSP90AA2 GenScript Custom overexpressing Cell Line Services for HSP90AA2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for HSP90AA2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for HSP90AA2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HSP90AA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HSP90AA2
     Browse SwitchGear Promoter luciferase reporter plasmids for HSP90AA2
     Search ThermoFisher Antibodies for HSP90AA2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA2
     ApexBio compounds for HSP90AA2
     Search Addgene for plasmids for HSP90AA2
      Search eBioscience for proteins for HSP90AA2
      Search eBioscience for elisas for HSP90AA2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HSP90AA2
     antibodies-online antibodies for HSP90AA2 (62 products)
     antibodies-online kits for HSP90AA2 (2 products)
     antibodies-online peptides for HSP90AA2
     antibodies-online proteins for HSP90AA2 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSP90AA2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4