Aliases for HSP90AA1 Gene
Aliases for HSP90AA1 Gene
- Heat Shock Protein 90 Alpha Family Class A Member 1 2 3 5
- Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
- Lipopolysaccharide-Associated Protein 2 3 4
- Heat Shock 90kDa Protein 1, Alpha 2 3
- Renal Carcinoma Antigen NY-REN-38 3 4
- Heat Shock 90kD Protein 1, Alpha 2 3
- LPS-Associated Protein 2 3 4
- Heat Shock 86 KDa 3 4
- HSP 86 3 4
- HSP90A 3 4
- HSPC1 3 4
- HSPCA 3 4
- HSP86 3 4
- LAP-2 3 4
- Heat Shock Protein 90kDa Alpha Family Class A Member 1 3
- Epididymis Secretory Sperm Binding Protein Li 65p 3
External Ids for HSP90AA1 Gene
- HGNC: 5253
- Entrez Gene: 3320
- Ensembl: ENSG00000080824
- OMIM: 140571
- UniProtKB: P07900
Previous HGNC Symbols for HSP90AA1 Gene
- HSPC1
- HSPCA
Previous GeneCards Identifiers for HSP90AA1 Gene
- GC14M101619
- GC14M102547
Summaries for HSP90AA1 Gene
-
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for HSP90AA1 Gene
HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Hypersensitivity Reaction Type Iii Disease and Epidermolysis Bullosa Acquisita. Among its related pathways are Development IGF-1 receptor signaling and CCR5 Pathway in Macrophages. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is HSP90AB1.
UniProtKB/Swiss-Prot for HSP90AA1 Gene
-
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
-
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene
Genomics for HSP90AA1 Gene
Regulatory Elements for HSP90AA1 Gene
Enhancers for HSP90AA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:
Regulatory Element Products
Genomic Location for HSP90AA1 Gene
- Chromosome:
- 14
- Start:
- 102,080,738 bp from pter
- End:
- 102,139,759 bp from pter
- Size:
- 59,022 bases
- Orientation:
- Minus strand
Genomic View for HSP90AA1 Gene
Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.31 by Ensembl
- 14q32.31 by Entrez Gene
- 14q32.31 by HGNC
HSP90AA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSP90AA1 Gene
Proteins for HSP90AA1 Gene
-
Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07900-HS90A_HUMAN
- Recommended name:
- Heat shock protein HSP 90-alpha
- Protein Accession:
- P07900
- A8K500
- B3KPJ9
- Q2PP14
- Q5CAQ6
- Q5CAQ7
- Q9BVQ5
Protein attributes for HSP90AA1 Gene
- Size:
- 732 amino acids
- Molecular mass:
- 84660 Da
- Quaternary structure:
-
- Homodimer (PubMed:7588731, PubMed:8289821, PubMed:18400751). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with AHSA1; the interaction activates HSP90AA1 ATPase activity (PubMed:12604615, PubMed:27353360). Interacts with FLCN in the presence of FNIP1. Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998. PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823).
Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene
Protein Expression for HSP90AA1 Gene
Post-translational modifications for HSP90AA1 Gene
- ISGylated.
- S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
- Ubiquitination at isoforms=284, posLast=294294, isoforms=2314, posLast=419419, posLast=436436, posLast=446446, isoforms=2478, and isoforms=2513
- Modification sites at PhosphoSitePlus
Other Protein References for HSP90AA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
- Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)
- Novus Biologicals Antibodies for HSP90AA1
-
Cloud-Clone Corp. Antibodies for HSP90AA1
- Invitrogen Antibodies for HSP90AA1
- antibodies-online Antibodies for HSP90AA1: See all 322
- GeneTex HSP90AA1 antibody for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1
Protein Products
- R&D Systems Proteins and Enzymes for HSP90AA1 (HSP90 alpha)
-
OriGene Purified Proteins for HSP90AA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSP90AA1
- Origene Custom Protein Services for HSP90AA1
- Sino Biological Recombinant Proteins for HSP90AA1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HSP90AA1
-
Cloud-Clone Corp. Proteins for HSP90AA1
- antibodies-online Proteins for HSP90AA1: See all 10
- Search antibodies-online for peptides
- GeneTex Proteins for HSP90AA1
Assay Products
- antibodies-online Kits for HSP90AA1: See all 47
No data available for DME Specific Peptides for HSP90AA1 Gene
Domains & Families for HSP90AA1 Gene
Gene Families for HSP90AA1 Gene
Protein Domains for HSP90AA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HSP90AA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07900UniProtKB/Swiss-Prot:
HS90A_HUMAN :- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Belongs to the heat shock protein 90 family.
- Domain:
-
- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Family:
-
- Belongs to the heat shock protein 90 family.
Function for HSP90AA1 Gene
Molecular function for HSP90AA1 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=300 uM for ATP {ECO:0000269 PubMed:18400751};
- UniProtKB/Swiss-Prot EnzymeRegulation:
- In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | TAS | 11470816 |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0004713 | protein tyrosine kinase activity | EXP | 17349580 |
| GO:0005515 | protein binding | IPI | 9660753 |
| GO:0005524 | ATP binding | IEA,TAS | 11470816 |
Phenotypes for HSP90AA1 Gene
- MGI mutant phenotypes for HSP90AA1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HSP90AA1:
Animal Models for HSP90AA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HSP90AA1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- Search ViGene Biosciences for HSP90AA1
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA for HSP90AA1 Gene
- miRTarBase miRNAs that target HSP90AA1
-
- hsa-mir-375 (MIRT020063)
- hsa-mir-16-5p (MIRT031959)
- hsa-mir-1226-3p (MIRT036428)
- hsa-mir-760 (MIRT036729)
- hsa-mir-425-5p (MIRT039331)
- hsa-mir-421 (MIRT039416)
- hsa-mir-501-5p (MIRT041140)
- hsa-mir-484 (MIRT041642)
- hsa-mir-324-3p (MIRT042829)
- hsa-mir-378a-3p (MIRT043944)
- hsa-mir-30e-5p (MIRT044155)
- hsa-mir-186-5p (MIRT045178)
- hsa-mir-185-5p (MIRT045325)
- hsa-mir-222-3p (MIRT046648)
- hsa-mir-204-5p (MIRT047015)
- hsa-mir-183-5p (MIRT047124)
- hsa-mir-10a-5p (MIRT047507)
- hsa-mir-30c-5p (MIRT047953)
- hsa-mir-25-3p (MIRT050304)
- hsa-mir-17-5p (MIRT050979)
- hsa-let-7b-5p (MIRT052238)
- hsa-mir-3943 (MIRT052896)
- hsa-mir-1277-5p (MIRT069282)
- hsa-mir-4703-3p (MIRT190328)
- hsa-mir-4677-3p (MIRT277530)
- hsa-mir-4679 (MIRT277531)
- hsa-mir-889-3p (MIRT277538)
- hsa-mir-1323 (MIRT438030)
- hsa-mir-34c-5p (MIRT438031)
- hsa-mir-371a-5p (MIRT438032)
- hsa-mir-3674 (MIRT493566)
- hsa-mir-374a-3p (MIRT493567)
- hsa-mir-4732-5p (MIRT493568)
- hsa-mir-6832-5p (MIRT493569)
- hsa-mir-219a-2-3p (MIRT493570)
- hsa-mir-4257 (MIRT493571)
- hsa-mir-6847-5p (MIRT493572)
- hsa-mir-2115-3p (MIRT493573)
- hsa-mir-1278 (MIRT493574)
- hsa-mir-6859-5p (MIRT493575)
- hsa-mir-3916 (MIRT493576)
- hsa-mir-3125 (MIRT493577)
- hsa-mir-4724-5p (MIRT493578)
- hsa-mir-361-5p (MIRT493579)
- hsa-mir-499b-5p (MIRT511420)
- hsa-mir-500b-5p (MIRT511421)
- hsa-mir-362-5p (MIRT511422)
- hsa-mir-656-3p (MIRT511423)
- hsa-mir-224-5p (MIRT511424)
- hsa-mir-7-2-3p (MIRT511425)
- hsa-mir-7-1-3p (MIRT511426)
- hsa-mir-3133 (MIRT511427)
- hsa-mir-495-3p (MIRT511428)
- hsa-mir-5688 (MIRT511429)
- hsa-mir-139-5p (MIRT541190)
- hsa-mir-6798-3p (MIRT541191)
- hsa-mir-582-5p (MIRT541192)
- hsa-mir-101-3p (MIRT541193)
- hsa-mir-550a-3p (MIRT541194)
- hsa-mir-200c-5p (MIRT541195)
- hsa-mir-600 (MIRT541196)
- hsa-mir-152-3p (MIRT541197)
- hsa-mir-148b-3p (MIRT541198)
- hsa-mir-148a-3p (MIRT541199)
- hsa-mir-497-3p (MIRT541200)
- hsa-mir-5590-5p (MIRT567246)
- hsa-mir-6826-3p (MIRT567247)
- hsa-mir-6755-3p (MIRT567248)
- hsa-mir-6756-3p (MIRT567249)
- hsa-mir-3127-3p (MIRT567250)
- hsa-mir-141-5p (MIRT567251)
- hsa-mir-1244 (MIRT567252)
- hsa-mir-548l (MIRT567253)
- hsa-mir-8054 (MIRT567254)
- hsa-mir-548k (MIRT567255)
- hsa-mir-548av-5p (MIRT567256)
- hsa-mir-559 (MIRT567257)
- hsa-mir-548y (MIRT567258)
- hsa-mir-548w (MIRT567259)
- hsa-mir-548o-5p (MIRT567260)
- hsa-mir-548j-5p (MIRT567261)
- hsa-mir-548i (MIRT567262)
- hsa-mir-548h-5p (MIRT567263)
- hsa-mir-548d-5p (MIRT567264)
- hsa-mir-548c-5p (MIRT567265)
- hsa-mir-548bb-5p (MIRT567266)
- hsa-mir-548b-5p (MIRT567267)
- hsa-mir-548ay-5p (MIRT567268)
- hsa-mir-548au-5p (MIRT567269)
- hsa-mir-548as-5p (MIRT567270)
- hsa-mir-548ar-5p (MIRT567271)
- hsa-mir-548aq-5p (MIRT567272)
- hsa-mir-548ap-5p (MIRT567273)
- hsa-mir-548am-5p (MIRT567274)
- hsa-mir-548ak (MIRT567275)
- hsa-mir-548ae-5p (MIRT567276)
- hsa-mir-548ad-5p (MIRT567277)
- hsa-mir-548ab (MIRT567278)
- hsa-mir-548a-5p (MIRT567279)
miRNA Products
- Search ViGene Biosciences for HSP90AA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HSP90AA1
- Browse OriGene Inhibitory RNA Products For HSP90AA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HSP90AA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HSP90AA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for HSP90AA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene
Localization for HSP90AA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene
- Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| lysosome | 5 |
| mitochondrion | 3 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| endosome | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0005634 | nucleus | ISS,IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | ISS,IEA | -- |
Pathways & Interactions for HSP90AA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Signaling by EGFR in Cancer | ||
| 3 | eNOS activation and regulation |
.01
|
|
| 4 | Influenza Viral RNA Transcription and Replication |
.01
|
|
| 5 | HIV Life Cycle |
.45
|
|
Pathways by source for HSP90AA1 Gene
2 Sino Biological pathways for HSP90AA1 Gene
2 GeneTex pathways for HSP90AA1 Gene
23 BioSystems pathways for HSP90AA1 Gene
64 Reactome pathways for HSP90AA1 Gene
1 PharmGKB pathway for HSP90AA1 Gene
11 KEGG pathways for HSP90AA1 Gene
6 GeneGo (Thomson Reuters) pathways for HSP90AA1 Gene
2 R&D Systems pathways for HSP90AA1 Gene
1 Tocris pathway for HSP90AA1 Gene
11 Qiagen pathways for HSP90AA1 Gene
Interacting Proteins for HSP90AA1 Gene
Selected Interacting proteins:
ENSP00000335153
P07900-HS90A_HUMAN
for HSP90AA1 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for HSP90AA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0006457 | protein folding | IEA | -- |
| GO:0006839 | mitochondrial transport | TAS | 12526792 |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0006950 | response to stress | IEA | -- |
Drugs & Compounds for HSP90AA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rifabutin | Approved | Pharma | Target, other/unknown | 56 | ||
| Nedocromil | Approved | Pharma | Target | 5 | ||
| Geldanamycin | Experimental | Pharma | Target | Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor | 0 | |
| Radicicol | Experimental | Pharma | ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic | 0 | ||
| (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 17-AAG |
|
75747-14-7 |
|
|
(5) Tocris Compounds for HSP90AA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 17-AAG | Selective Hsp90 inhibitor | 75747-14-7 |
| EC 144 | High affinity, potent and selective Hsp90 inhibitor | 911397-80-3 |
| Gedunin | Hsp90 inhibitor; exhibits anticancer and antimalarial activity | 2753-30-2 |
| Geldanamycin | Selective Hsp90 inhibitor | 30562-34-6 |
| Radicicol | Hsp90 inhibitor. Antifungal antibiotic | 12772-57-5 |
(29) ApexBio Compounds for HSP90AA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 17-AAG (KOS953) | Hsp90 inhibitor | 75747-14-7 |
| 17-AAG Hydrochloride | Hsp90 inhibitor,geldanamycin analogue | 911710-03-7 |
| 17-DMAG (Alvespimycin) HCl | Hsp90 inhibitor | 467214-21-7 |
| Alvespimycin | Hsp90 inhibitor,potent and selective | 467214-20-6 |
| AT13387 | Hsp90 inhibitor | 912999-49-6 |
| AUY922 (NVP-AUY922) | Potent Hsp90 inhibitor | 747412-49-3 |
| BIIB021 | Hsp90 inhibitor,selective and competitive | 848695-25-0 |
| CH5138303 | 959763-06-5 | |
| EC 144 | 911397-80-3 | |
| Ganetespib (STA-9090) | Hsp90 inhibitor,non-geldanamycin | 888216-25-9 |
| Gedunin | naturally occurring Hsp90 inhibitor | 2753-30-2 |
| Geldanamycin | Hsp90 inhibitor,potent and specific | 30562-34-6 |
| HSP990 (NVP-HSP990) | 934343-74-5 | |
| IPI-504 (Retaspimycin hydrochloride) | Hsp90 inhibitor,novel, potent,selective | 857402-63-2 |
| KNK437 | stress-induced HSP synthesis inhibitor | 218924-25-5 |
| KW-2478 | Potent Hsp90 inhibitor, novel, non-ansamycin, | 819812-04-9 |
| Macbecin I | 73341-72-7 | |
| MPC-3100 | Hsp90 inhibitor | 958025-66-6 |
| NMS-E973 | Hsp90 inhibitor,potent and selective | 1253584-84-7 |
| NVP-BEP800 | Oral Hsp90β inhibitor, novel, fully synthetic | 847559-80-2 |
| PF-04929113 (SNX-5422) | Hsp90 inhibitor,potent and selective | 908115-27-5 |
| PU-H71 | Hsp90 inhibitor,potent and selective | 873436-91-0 |
| PU-WS13 | Grp94-specific Hsp90 inhibitor | 1454619-14-7 |
| Radicicol | ATPase/kinase inhibitor | 12772-57-5 |
| Retaspimycin | HSP90 inhibitor,antiproliferative and antineoplastic | 857402-23-4 |
| SNX-2112 | Hsp90 inhibitor,ATP-competitve,potent and selective | 908112-43-6 |
| VER-49009 | 558640-51-0 | |
| VER-50589 | 747413-08-7 | |
| XL-888 | Hsp90 inhibitor | 1149705-71-4 |
Transcripts for HSP90AA1 Gene
mRNA/cDNA for HSP90AA1 Gene
- (3) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (2627) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HSP90AA1 Gene
- Heat shock protein 90kDa alpha (cytosolic), class A member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA Products
- Search ViGene Biosciences for HSP90AA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HSP90AA1
- Browse OriGene Inhibitory RNA Products For HSP90AA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HSP90AA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HSP90AA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
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| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| SP14: |
| ExUns: | 16a | · | 16b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
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| SP5: | |||
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| SP14: |
Expression for HSP90AA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Neural Tube (Nervous System)
- Tooth (Integumentary System)
- Liver (Hepatobiliary System)
- Endoderm (Gastrulation Derivatives)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSP90AA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HSP90AA1 Gene:
HSP90AA1SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene:
Hs.525600Evidence on tissue expression from TISSUES for HSP90AA1 Gene
- Liver(5)
- Nervous system(5)
- Blood(4.9)
- Heart(4.9)
- Lung(4.9)
- Skin(4.9)
- Intestine(4.8)
- Kidney(4.8)
- Eye(4.6)
- Pancreas(4.5)
- Stomach(4.3)
- Bone(4.2)
- Muscle(4.1)
- Spleen(3.5)
- Adrenal gland(3.1)
- Bone marrow(3)
- Lymph node(3)
- Thyroid gland(2.6)
- Gall bladder(2.3)
Primer Products
-
OriGene qPCR primer pairs for HSP90AA1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA1 Gene
Orthologs for HSP90AA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HSP90AA1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HSP90AA1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSP90AA1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hsp90aa1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hsp90aa1 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HSP90AA1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HSP90AA1 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | HSP90AA1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HSP90AA1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsp90aa1.1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hsp90aa1.2 34 35 |
|
||
| -- 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Hsp83 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-21 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSP82 35 |
|
OneToMany | |
| HSC82 37 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HSP81-2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0482100 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11103 35 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3846 34 |
|
- Species where no ortholog for HSP90AA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HSP90AA1 Gene
(14) SIMAP similar genes for HSP90AA1 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for HSP90AA1 Gene
Variants for HSP90AA1 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055689 | -- | 102,139,847(+) | GGGAA(A/G)AGGGA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1000062529 | -- | 102,110,873(+) | ACTGC(A/G)CCCAG | intron-variant | |
| rs1000100990 | -- | 102,116,518(+) | TTCCC(A/G)AGGCA | intron-variant | |
| rs1000151696 | -- | 102,096,101(+) | GCACC(C/T)CCAGC | intron-variant | |
| rs1000176361 | -- | 102,108,647(+) | TCTCC(C/T)GCCTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv25n68 | CNV | loss | 17160897 |
| esv25342 | CNV | loss | 19812545 |
| esv2670326 | CNV | deletion | 23128226 |
| esv3552074 | CNV | deletion | 23714750 |
| esv3635541 | CNV | loss | 21293372 |
| esv3635542 | CNV | loss | 21293372 |
| esv3635543 | CNV | loss | 21293372 |
| nsv1113674 | CNV | deletion | 24896259 |
| nsv1131163 | CNV | deletion | 24896259 |
| nsv1428 | CNV | insertion | 18451855 |
| nsv565947 | CNV | gain | 21841781 |
| nsv832879 | CNV | loss | 17160897 |
| nsv976371 | CNV | duplication | 23825009 |
| nsv983856 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.05;
37.57% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HSP90AA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene
Disorders for HSP90AA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypersensitivity reaction type iii disease |
|
|
| epidermolysis bullosa acquisita |
|
|
| candidiasis |
|
|
| lobular neoplasia |
|
|
| hypersensitivity vasculitis |
|
|
Search HSP90AA1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HSP90AA1
No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene
Publications for HSP90AA1 Gene
- A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PMID: 19875381) Gano J.J. … Simon J.A. (Mol. Cell. Proteomics 2010) 3 4 22 64
- Hsp90 is regulated by a switch point in the C-terminal domain. (PMID: 19696785) Retzlaff M. … Buchner J. (EMBO Rep. 2009) 3 4 22 64
- Conserved conformational changes in the ATPase cycle of human Hsp90. (PMID: 18400751) Richter K. … Buchner J. (J. Biol. Chem. 2008) 3 4 22 64
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 4 64
- S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PMID: 15937123) Martinez-Ruiz A. … Lamas S. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4 22 64
Products for HSP90AA1 Gene
- R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
- R&D Systems Proteins and Enzymes for HSP90AA1 (HSP90 alpha)
- Browse R&D Systems for biochemical assays
- R&D Systems Small Molecules for HSP90AA1 (HSP90 alpha)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HSP90AA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HSP90AA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSP90AA1
- Origene Custom Protein Services for HSP90AA1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HSP90AA1
- Browse OriGene Inhibitory RNA Products For HSP90AA1
- OriGene qPCR primer pairs for HSP90AA1
- OriGene CRISPR knockouts for HSP90AA1
- OriGene ORF clones in human for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HSP90AA1
- GenScript: Next-day shipping cDNA ORF clone for HSP90AA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
- GenScript Custom Assay Services for HSP90AA1
- GenScript Custom overexpressing Cell Line Services for HSP90AA1
- Browse GenScript CRISPR for HSP90AA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HSP90AA1
- Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HSP90AA1
- Sino Biological Recombinant Proteins for HSP90AA1
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HSP90AA1
- Novus Biologicals proteins and lysates for HSP90AA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HSP90AA1
- Cloud-Clone Corp. Antibodies for HSP90AA1
- Cloud-Clone Corp. Proteins for HSP90AA1
- Browse Assay Kits at Cloud-Clone Corp.
- Invitrogen Antibodies for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for HSP90AA1
- antibodies-online Antibodies for HSP90AA1: See all 322
- antibodies-online Kits for HSP90AA1: See all 47
- antibodies-online Proteins for HSP90AA1: See all 10
- Search antibodies-online for peptides
- GeneTex HSP90AA1 antibody for HSP90AA1
- GeneTex Proteins for HSP90AA1
- ViGene Biosciences adenoviral particle packaged cDNA for HSP90AA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- Search ViGene Biosciences for HSP90AA1
- Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1
- Search Santa Cruz Biotechnology (SCBT) for HSP90AA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
- Horizon Cell Lines for HSP90AA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HSP90AA1
- VectorBuilder custom plasmid, inducible vectors for HSP90AA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HSP90AA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HSP90AA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
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- (68) Abcam
- (69) Novus
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- (71) Sino Biological
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (77) Proteopedia
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