Aliases for HSP90AA1 Gene
Aliases for HSP90AA1 Gene
- Heat Shock Protein 90kDa Alpha Family Class A Member 1 2 3 5
- Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
- Lipopolysaccharide-Associated Protein 2 3 4
- Heat Shock 90kDa Protein 1, Alpha 2 3
- Renal Carcinoma Antigen NY-REN-38 3 4
- Heat Shock 90kD Protein 1, Alpha 2 3
- LPS-Associated Protein 2 3 4
- Heat Shock 86 KDa 3 4
- HSP 86 3 4
- HSP90A 3 4
- HSPC1 3 4
- HSPCA 3 4
- HSP86 3 4
- LAP-2 3 4
- Epididymis Secretory Sperm Binding Protein Li 65p 3
External Ids for HSP90AA1 Gene
- HGNC: 5253
- Entrez Gene: 3320
- Ensembl: ENSG00000080824
- OMIM: 140571
- UniProtKB: P07900
Previous HGNC Symbols for HSP90AA1 Gene
- HSPC1
- HSPCA
Previous GeneCards Identifiers for HSP90AA1 Gene
- GC14M101619
- GC14M102547
Summaries for HSP90AA1 Gene
-
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
GeneCards Summary for HSP90AA1 Gene
HSP90AA1 (Heat Shock Protein 90kDa Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Lobular Neoplasia and Candidiasis. Among its related pathways are Uptake and actions of bacterial toxins and Regulation of actin dynamics for phagocytic cup formation. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is HSP90AB1.
UniProtKB/Swiss-Prot for HSP90AA1 Gene
-
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
-
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).
No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene
Genomics for HSP90AA1 Gene
Regulatory Elements for HSP90AA1 Gene
Enhancers for HSP90AA1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:
Regulatory Element Products
Genomic Location for HSP90AA1 Gene
- Chromosome:
- 14
- Start:
- 102,080,738 bp from pter
- End:
- 102,139,759 bp from pter
- Size:
- 59,022 bases
- Orientation:
- Minus strand
Genomic View for HSP90AA1 Gene
Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.31 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
HSP90AA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HSP90AA1 Gene
Proteins for HSP90AA1 Gene
-
Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07900-HS90A_HUMAN
- Recommended name:
- Heat shock protein HSP 90-alpha
- Protein Accession:
- P07900
- A8K500
- B3KPJ9
- Q2PP14
- Q5CAQ6
- Q5CAQ7
- Q9BVQ5
Protein attributes for HSP90AA1 Gene
- Size:
- 732 amino acids
- Molecular mass:
- 84660 Da
- Quaternary structure:
-
- Homodimer (PubMed:7588731, PubMed:8289821). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34 (PubMed:11583998, PubMed:12604615, PubMed:15235609, PubMed:17028174, PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). May interact with NWD1 (PubMed:24681825).
Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene
Protein Expression for HSP90AA1 Gene
Post-translational modifications for HSP90AA1 Gene
- ISGylated.
- S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
- Ubiquitination at Lys 84, Lys 294, Lys 314, Lys 419, Lys 436, Lys 446, Lys 478, and Lys 513
- Modification sites at PhosphoSitePlus
Other Protein References for HSP90AA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HSP90AA1
- R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
- Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)
- Novus Biologicals Antibodies for HSP90AA1
-
Cloud-Clone Corp. Antibodies for HSP90AA1
- Invitrogen Antibodies for HSP90AA1
- antibodies-online Antibodies for HSP90AA1: See all 322
- GeneTex HSP90AA1 antibody for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1
Protein Products
- R&D Systems Proteins and Enzymes for HSP90AA1 (HSP90 alpha)
- Enzo Life Sciences proteins for HSP90AA1
-
OriGene Purified Proteins for HSP90AA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSP90AA1
- Origene Custom Protein Services for HSP90AA1
- Sino Biological Recombinant Proteins for HSP90AA1
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for HSP90AA1
-
Cloud-Clone Corp. Proteins for HSP90AA1
- antibodies-online Proteins for HSP90AA1: See all 10
- Search antibodies-online for peptides
- GeneTex Heat Shock Protein 90 recombinant protein (GTX65117) for HSP90AA1
Assay Products
- Enzo Life Sciences assays for HSP90AA1
-
Cloud-Clone Corp Assay Kits for HSP90AA1
- antibodies-online Kits for HSP90AA1: See all 47
No data available for DME Specific Peptides for HSP90AA1 Gene
Domains & Families for HSP90AA1 Gene
Gene Families for HSP90AA1 Gene
Protein Domains for HSP90AA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HSP90AA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07900UniProtKB/Swiss-Prot:
HS90A_HUMAN :- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Belongs to the heat shock protein 90 family.
- Domain:
-
- The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
- Family:
-
- Belongs to the heat shock protein 90 family.
Function for HSP90AA1 Gene
Molecular function for HSP90AA1 Gene
- UniProtKB/Swiss-Prot Function:
- Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | EXP | 17349580 |
| GO:0016887 | ATPase activity | IDA | 15937123 |
| GO:0023026 | MHC class II protein complex binding | IDA | 20458337 |
| GO:0042826 | histone deacetylase binding | IPI | 16809764 |
| GO:0044822 | poly(A) RNA binding | IDA | 22658674 |
Phenotypes for HSP90AA1 Gene
- MGI mutant phenotypes for HSP90AA1:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for HSP90AA1:
Animal Models for HSP90AA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- Search ViGene Biosciences for HSP90AA1
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA for HSP90AA1 Gene
- miRTarBase miRNAs that target HSP90AA1
-
- hsa-mir-375 (MIRT020063)
- hsa-mir-16-5p (MIRT031959)
- hsa-mir-1226-3p (MIRT036428)
- hsa-mir-760 (MIRT036729)
- hsa-mir-425-5p (MIRT039331)
- hsa-mir-421 (MIRT039416)
- hsa-mir-501-5p (MIRT041140)
- hsa-mir-484 (MIRT041642)
- hsa-mir-324-3p (MIRT042829)
- hsa-mir-378a-3p (MIRT043944)
- hsa-mir-30e-5p (MIRT044155)
- hsa-mir-186-5p (MIRT045178)
- hsa-mir-185-5p (MIRT045325)
- hsa-mir-222-3p (MIRT046648)
- hsa-mir-204-5p (MIRT047015)
- hsa-mir-183-5p (MIRT047124)
- hsa-mir-10a-5p (MIRT047507)
- hsa-mir-30c-5p (MIRT047953)
- hsa-mir-25-3p (MIRT050304)
- hsa-mir-17-5p (MIRT050979)
- hsa-let-7b-5p (MIRT052238)
- hsa-mir-3943 (MIRT052896)
- hsa-mir-1277-5p (MIRT069282)
- hsa-mir-4703-3p (MIRT190328)
- hsa-mir-4677-3p (MIRT277530)
- hsa-mir-4679 (MIRT277531)
- hsa-mir-889-3p (MIRT277538)
- hsa-mir-1323 (MIRT438030)
- hsa-mir-34c-5p (MIRT438031)
- hsa-mir-371a-5p (MIRT438032)
- hsa-mir-3674 (MIRT493566)
- hsa-mir-374a-3p (MIRT493567)
- hsa-mir-4732-5p (MIRT493568)
- hsa-mir-6832-5p (MIRT493569)
- hsa-mir-219a-2-3p (MIRT493570)
- hsa-mir-4257 (MIRT493571)
- hsa-mir-6847-5p (MIRT493572)
- hsa-mir-2115-3p (MIRT493573)
- hsa-mir-1278 (MIRT493574)
- hsa-mir-6859-5p (MIRT493575)
- hsa-mir-3916 (MIRT493576)
- hsa-mir-3125 (MIRT493577)
- hsa-mir-4724-5p (MIRT493578)
- hsa-mir-361-5p (MIRT493579)
- hsa-mir-499b-5p (MIRT511420)
- hsa-mir-500b-5p (MIRT511421)
- hsa-mir-362-5p (MIRT511422)
- hsa-mir-656-3p (MIRT511423)
- hsa-mir-224-5p (MIRT511424)
- hsa-mir-7-2-3p (MIRT511425)
- hsa-mir-7-1-3p (MIRT511426)
- hsa-mir-3133 (MIRT511427)
- hsa-mir-495-3p (MIRT511428)
- hsa-mir-5688 (MIRT511429)
- hsa-mir-139-5p (MIRT541190)
- hsa-mir-6798-3p (MIRT541191)
- hsa-mir-582-5p (MIRT541192)
- hsa-mir-101-3p (MIRT541193)
- hsa-mir-550a-3p (MIRT541194)
- hsa-mir-200c-5p (MIRT541195)
- hsa-mir-600 (MIRT541196)
- hsa-mir-152-3p (MIRT541197)
- hsa-mir-148b-3p (MIRT541198)
- hsa-mir-148a-3p (MIRT541199)
- hsa-mir-497-3p (MIRT541200)
- hsa-mir-5590-5p (MIRT567246)
- hsa-mir-6826-3p (MIRT567247)
- hsa-mir-6755-3p (MIRT567248)
- hsa-mir-6756-3p (MIRT567249)
- hsa-mir-3127-3p (MIRT567250)
- hsa-mir-141-5p (MIRT567251)
- hsa-mir-1244 (MIRT567252)
- hsa-mir-548l (MIRT567253)
- hsa-mir-8054 (MIRT567254)
- hsa-mir-548k (MIRT567255)
- hsa-mir-548av-5p (MIRT567256)
- hsa-mir-559 (MIRT567257)
- hsa-mir-548y (MIRT567258)
- hsa-mir-548w (MIRT567259)
- hsa-mir-548o-5p (MIRT567260)
- hsa-mir-548j-5p (MIRT567261)
- hsa-mir-548i (MIRT567262)
- hsa-mir-548h-5p (MIRT567263)
- hsa-mir-548d-5p (MIRT567264)
- hsa-mir-548c-5p (MIRT567265)
- hsa-mir-548bb-5p (MIRT567266)
- hsa-mir-548b-5p (MIRT567267)
- hsa-mir-548ay-5p (MIRT567268)
- hsa-mir-548au-5p (MIRT567269)
- hsa-mir-548as-5p (MIRT567270)
- hsa-mir-548ar-5p (MIRT567271)
- hsa-mir-548aq-5p (MIRT567272)
- hsa-mir-548ap-5p (MIRT567273)
- hsa-mir-548am-5p (MIRT567274)
- hsa-mir-548ak (MIRT567275)
- hsa-mir-548ae-5p (MIRT567276)
- hsa-mir-548ad-5p (MIRT567277)
- hsa-mir-548ab (MIRT567278)
- hsa-mir-548a-5p (MIRT567279)
miRNA Products
- Search ViGene Biosciences for HSP90AA1
Clone Products
- OriGene clones in human for HSP90AA1
- OriGene ORF clones in human,mouse,rat for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene
Localization for HSP90AA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene
- Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 5 |
| lysosome | 5 |
| nucleus | 5 |
| plasma membrane | 5 |
| vacuole | 5 |
| mitochondrion | 3 |
| chloroplast | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,ISS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0042470 | melanosome | IEA | -- |
| GO:0043202 | lysosomal lumen | TAS | 25719862 |
| GO:0070062 | extracellular exosome | IDA | 11487543 |
Pathways & Interactions for HSP90AA1 Gene
More details on SuperPathways for HSP90AA1Pathways by source for HSP90AA1 Gene
2 GeneTex pathways for HSP90AA1 Gene
20 BioSystems pathways for HSP90AA1 Gene
59 Reactome pathways for HSP90AA1 Gene
1 PharmGKB pathway for HSP90AA1 Gene
8 KEGG pathways for HSP90AA1 Gene
6 GeneGo (Thomson Reuters) pathways for HSP90AA1 Gene
2 R&D Systems pathways for HSP90AA1 Gene
1 Tocris pathway for HSP90AA1 Gene
11 Qiagen pathways for HSP90AA1 Gene
Interacting Proteins for HSP90AA1 Gene
Selected Interacting proteins:
P07900-HS90A_HUMAN
ENSP00000335153
for HSP90AA1 Gene via
MINT
STRING
UniProtKB
I2D
SIGNOR curated interactions for HSP90AA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001764 | neuron migration | IEA | -- |
| GO:0006839 | mitochondrial transport | TAS | 12526792 |
| GO:0006898 | receptor-mediated endocytosis | TAS | -- |
| GO:0018108 | peptidyl-tyrosine phosphorylation | EXP | 17349580 |
| GO:0031396 | regulation of protein ubiquitination | IDA | 16809764 |
Drugs & Compounds for HSP90AA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rifabutin | Approved | Pharma | Target, other/unknown | 52 | ||
| Nedocromil | Approved | Pharma | Target | 5 | ||
| Geldanamycin | Experimental | Pharma | Target | Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor | 0 | |
| 17-Dmag | Experimental | Pharma | Target | 0 | ||
| Radicicol | Experimental | Pharma | Hsp90 inhibitor. Antifungal antibiotic | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 17-AAG |
|
75747-14-7 |
|
|
||
| CCT 018159 |
|
171009-07-7 |
|
|
(5) Tocris Compounds for HSP90AA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 17-AAG | Selective Hsp90 inhibitor | 75747-14-7 |
| CCT 018159 | Hsp90 inhibitor | 171009-07-7 |
| Geldanamycin | Selective Hsp90 inhibitor | 30562-34-6 |
| Herbimycin A | Src family kinase inhibitor. Also Hsp90 inhibitor | 70563-58-5 |
| Radicicol | Hsp90 inhibitor. Antifungal antibiotic | 12772-57-5 |
(19) ApexBio Compounds for HSP90AA1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| 17-AAG (KOS953) | Hsp90 inhibitor | 75747-14-7 |
| 17-DMAG (Alvespimycin) HCl | Hsp90 inhibitor | 467214-21-7 |
| AT13387 | Hsp90 inhibitor | 912999-49-6 |
| AUY922 (NVP-AUY922) | Potent Hsp90 inhibitor | 747412-49-3 |
| BIIB021 | Hsp90 inhibitor,selective and competitive | 848695-25-0 |
| CH5138303 | 959763-06-5 | |
| Ganetespib (STA-9090) | Hsp90 inhibitor,non-geldanamycin | 888216-25-9 |
| Geldanamycin | Hsp90 inhibitor,potent and specific | 30562-34-6 |
| HSP990 (NVP-HSP990) | 934343-74-5 | |
| IPI-504 (Retaspimycin hydrochloride) | Hsp90 inhibitor,novel, potent,selective | 857402-63-2 |
| KW-2478 | Potent Hsp90 inhibitor, novel, non-ansamycin, | 819812-04-9 |
| NMS-E973 | Hsp90 inhibitor,potent and selective | 1253584-84-7 |
| NVP-BEP800 | Oral Hsp90β inhibitor, novel, fully synthetic | 847559-80-2 |
| PF-04929113 (SNX-5422) | Hsp90 inhibitor,potent and selective | 908115-27-5 |
| PU-H71 | Hsp90 inhibitor,potent and selective | 873436-91-0 |
| SNX-2112 | Hsp90 inhibitor,ATP-competitve,potent and selective | 908112-43-6 |
| VER-49009 | 558640-51-0 | |
| VER-50589 | 747413-08-7 | |
| XL-888 | Hsp90 inhibitor | 1149705-71-4 |
Transcripts for HSP90AA1 Gene
mRNA/cDNA for HSP90AA1 Gene
- (3) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (2627) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HSP90AA1 Gene
- Heat shock protein 90kDa alpha (cytosolic), class A member 1:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for HSP90AA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
miRNA Products
- Search ViGene Biosciences for HSP90AA1
Clone Products
- OriGene clones in human for HSP90AA1
- OriGene ORF clones in human,mouse,rat for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 16a | · | 16b |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: |
Expression for HSP90AA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
- Neural Tube (Nervous System)
- Tooth (Integumentary System)
- Liver (Hepatobiliary System)
- Endoderm (Gastrulation Derivatives)
-
Esophagus (Gastrointestinal Tract)
This gene is overexpressed in Lymph node (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90AA1 Gene
SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene Hs.525600
Primer Products
-
OriGene qPCR primer pairs for HSP90AA1
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90AA1 Gene
Orthologs for HSP90AA1 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HSP90AA1 35 |
|
||
| HSP90AA1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | HSP90AA1 35 |
|
||
| HSP90AA1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Hsp90aa1 35 |
|
||
| Hsp90aa1 16 |
|
||||
| Hsp90aa1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HSP90AA1 35 |
|
||
| HSP90AA1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Hsp90aa1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HSP90AA1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HSP90AA1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HSP90AA1 35 |
|
||
| HSP90AA1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | HSP90AA1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hsp90aa1.1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | -- 35 |
|
||
| hsp90aa1.2 35 |
|
||||
| hsp90aa1.2 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Hsp83 36 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-21 36 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HSP82 36 |
|
OneToMany | |
| HSC82 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | HSP81-2 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os09g0482100 35 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3846 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11103 36 |
|
OneToMany |
- Species with no ortholog for HSP90AA1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HSP90AA1 Gene
(14) SIMAP similar genes for HSP90AA1 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for HSP90AA1 Gene
Variants for HSP90AA1 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs7493672 | -- | 102,100,305(+) | GGAGC(A/G)TCAGG | intron-variant | |
| rs8018068 | -- | 102,125,414(+) | GAAAT(A/G)TGACC | intron-variant | |
| rs8004640 | -- | 102,086,436(+) | CACGA(A/C/G)ATTCC | intron-variant | |
| rs745313 | -- | 102,116,780(+) | caatg(A/G)ggctg | intron-variant | |
| rs1742626 | -- | 102,129,975(-) | ACAAA(A/C)CAAAA | intron-variant |
Residual Variation Intolerance Score:
3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.05;
37.57% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HSP90AA1 Gene
- Human Gene Mutation Database (HGMD)
- HSP90AA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene
Disorders for HSP90AA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lobular neoplasia |
|
|
| candidiasis |
|
|
| hypersensitivity vasculitis |
|
|
| atypical teratoid rhabdoid tumor |
|
|
| hypersensitivity reaction type iii disease |
|
|
Search HSP90AA1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HSP90AA1
No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene
Publications for HSP90AA1 Gene
- The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B. … Monteiro A. (Genomics 2005) 2 3 4 67
- Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. (PMID: 12803546) Okada M. … Kobayashi R. (Biochem. J. 2003) 23 25 26
- Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. (PMID: 11306472) MA1nster P.N. … Rosen N. (Cancer Res. 2001) 23 25 26
- Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. (PMID: 10919672) Srethapakdi M. … Rosen N. (Cancer Res. 2000) 23 25 26
- Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. (PMID: 19751963) Lee J.H. … Chung I.K. (Cancer Lett. 2010) 3 23
Products for HSP90AA1 Gene
- R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
- R&D Systems Proteins and Enzymes for HSP90AA1 (HSP90 alpha)
- Browse R&D Systems for biochemical assays
- R&D Systems Small Molecules for HSP90AA1 (HSP90 alpha)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HSP90AA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HSP90AA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HSP90AA1
- Origene Custom Protein Services for HSP90AA1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for HSP90AA1
- Browse OriGene Inhibitory RNA Products For HSP90AA1
- OriGene qPCR primer pairs for HSP90AA1
- OriGene CRISPR knockouts for HSP90AA1
- OriGene clones in human for HSP90AA1
- OriGene ORF clones in human,mouse,rat for HSP90AA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
- GenScript Custom Assay Services for HSP90AA1
- GenScript Custom overexpressing Cell Line Services for HSP90AA1
- Browse GenScript CRISPR for HSP90AA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HSP90AA1
- Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)
- Search for Antibodies & Assays
- Enzo Life Sciences proteins for HSP90AA1
- Enzo Life Sciences assays for HSP90AA1
- Browse drugs & compounds from Enzo Life Sciences
- Search Enzo Life Sciences for proteins, assays, substrates, inhibitors & antibodies
- Novus Biologicals Antibodies for HSP90AA1
- Novus Biologicals proteins and lysates for HSP90AA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HSP90AA1
- Cloud-Clone Corp. Antibodies for HSP90AA1
- Cloud-Clone Corp. Proteins for HSP90AA1
- Cloud-Clone Corp Assay Kits for HSP90AA1
- Invitrogen Antibodies for HSP90AA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for HSP90AA1
- antibodies-online Antibodies for HSP90AA1: See all 322
- antibodies-online Kits for HSP90AA1: See all 47
- antibodies-online Proteins for HSP90AA1: See all 10
- Search antibodies-online for peptides
- GeneTex HSP90AA1 antibody for HSP90AA1
- GeneTex Heat Shock Protein 90 recombinant protein (GTX65117) for HSP90AA1
- ViGene Biosciences adenoviral particle packaged cDNA for HSP90AA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HSP90AA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HSP90AA1 gene
- Search ViGene Biosciences for HSP90AA1
- Search ViGene Biosciences for HSP90AA1
- Santa Cruz Biotechnology (SCBT) Antibodies for HSP90AA1
- Search Santa Cruz Biotechnology (SCBT) for HSP90AA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HSP90AA1
Sources for HSP90AA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon