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HSP90AA1 Gene(Protein Coding)

Heat Shock Protein 90 Alpha Family Class A Member 1

GCID:
GC14M102080
GIFtS:
59
Genes Participants
UDN Logo

Aliases for HSP90AA1 Gene

Aliases for HSP90AA1 Gene

  • Heat Shock Protein 90 Alpha Family Class A Member 1 2 3 5
  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
  • Lipopolysaccharide-Associated Protein 2 3 4
  • Heat Shock 90kDa Protein 1, Alpha 2 3
  • Renal Carcinoma Antigen NY-REN-38 3 4
  • Heat Shock 90kD Protein 1, Alpha 2 3
  • LPS-Associated Protein 2 3 4
  • Heat Shock 86 KDa 3 4
  • HSP 86 3 4
  • HSP90A 3 4
  • HSPC1 3 4
  • HSPCA 3 4
  • HSP86 3 4
  • LAP-2 3 4
  • Heat Shock Protein 90kDa Alpha Family Class A Member 1 3
  • Epididymis Secretory Sperm Binding Protein Li 65p 3
  • Epididymis Luminal Secretory Protein 52 3
  • Heat Shock 90kD Protein 1, Alpha-Like 4 3
  • Heat Shock 90kD Protein, Alpha-Like 4 3
  • Heat Shock Protein HSP 90-Alpha 3
  • HEL-S-65p 3
  • HSPCAL1 3
  • HSPCAL4 3
  • HSP89A 3
  • HSP90N 3
  • Hsp103 3
  • Hsp89 3
  • Hsp90 3
  • LAP2 3
  • EL52 3
  • HSPN 3

External Ids for HSP90AA1 Gene

Previous HGNC Symbols for HSP90AA1 Gene

  • HSPC1
  • HSPCA

Previous GeneCards Identifiers for HSP90AA1 Gene

  • GC14M101619
  • GC14M102547

Summaries for HSP90AA1 Gene

Entrez Gene Summary for HSP90AA1 Gene

  • The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSP90AA1 Gene

HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include Epidermolysis Bullosa Acquisita and Hypersensitivity Reaction Type Iii Disease. Among its related pathways are PEDF Induced Signaling and EPH-Ephrin signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot for HSP90AA1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).

Tocris Summary for HSP90AA1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AA1 Gene

Additional gene information for HSP90AA1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene

Genomics for HSP90AA1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for HSP90AA1 Gene

Promoters and enhancers for HSP90AA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I102138 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -344 3 HDGF FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 KLF13 HSP90AA1 WDR20 CDC42BPB MOK ENSG00000271780 LOC105370677
GH14I101962 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 14.7 +174.9 174870 6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF143 FOS DYNC1H1 HSP90AA1 PPP2R5C WDR20 ZNF839 ENSG00000259013
GH14I102084 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +52.8 52828 4.7 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 RCOR1 WDR20 HSP90AA1 ZNF839 MOK PIR41764 GC14P103296
GH14I102303 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.4 -165.1 -165095 2.5 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 YY1 MOK WDR20 HSP90AA1 ENSG00000271780 RCOR1 CDC42BPB GC14P103295
GH14I101970 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +167.2 167177 3.6 PKNOX1 ATF1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 BRCA1 ZNF121 KLF7 HSP90AA1 WDR20 ENSG00000271780 ZNF839 DYNC1H1 PPP2R5C ENSG00000259013 ENSG00000258959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSP90AA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:

Genomic Locations for HSP90AA1 Gene

Genomic Locations for HSP90AA1 Gene
chr14:102,080,738-102,139,759
(GRCh38/hg38)
Size:
59,022 bases
Orientation:
Minus strand
chr14:102,547,075-102,606,086
(GRCh37/hg19)

Genomic View for HSP90AA1 Gene

Genes around HSP90AA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSP90AA1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HSP90AA1 Gene

Proteins for HSP90AA1 Gene

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  • Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07900-HS90A_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha
    Protein Accession:
    P07900
    Secondary Accessions:
    • A8K500
    • B3KPJ9
    • Q2PP14
    • Q5CAQ6
    • Q5CAQ7
    • Q9BVQ5

    Protein attributes for HSP90AA1 Gene

    Size:
    732 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    • Homodimer (PubMed:7588731, PubMed:8289821, PubMed:18400751). Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C or STIP1 (PubMed:15383005, PubMed:9195923). Interacts with TOM34 (PubMed:9660753). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (PubMed:11274138, PubMed:9817749). Interacts with CHORDC1 and DNAJC7 (PubMed:12853476, PubMed:19875381). Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems (PubMed:16307917, PubMed:27353360). Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity (PubMed:15383005, PubMed:15577939, PubMed:16531226, PubMed:27353360). Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8 (PubMed:11276205). Interacts with KSR1 (PubMed:10409742). Interacts with co-chaperone CDC37 (via C-terminus); the interaction inhibits HSP90AA1 ATPase activity (PubMed:23569206, PubMed:27353360). May interact with NWD1 (PubMed:24681825). Interacts with FNIP1 and FNIP2; the interaction inhibits HSP90AA1 ATPase activity (PubMed:17028174, PubMed:27353360). Interacts with AHSA1; the interaction activates HSP90AA1 ATPase activity (PubMed:12604615, PubMed:27353360). Interacts with FLCN in the presence of FNIP1. Interacts with HSP70, STIP1 and PTGES3 (PubMed:27353360). Interacts with SMYD3; this interaction enhances SMYD3 histone-lysine N-methyltransferase (PubMed:15235609, PubMed:25738358). Interacts with SGTA (via TPR repeats) (PubMed:15708368). Interacts with TTC1 (via TPR repeats) (PubMed:15708368). Interacts with HSF1 in an ATP-dependent manner (PubMed:11583998. PubMed:26517842). Interacts with MET; the interaction suppresses MET kinase activity. Interacts with ERBB2 in an ATP-dependent manner; the interaction suppresses ERBB2 kinase activity. Interacts with HIF1A, KEAP1 and RHOBTB2 (PubMed:26517842). Interacts with HSF1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Interacts with STUB1 and SMAD3 (PubMed:24613385). Interacts with HSP90AB1; interaction is constitutive (PubMed:20353823). Interacts with HECTD1 (via N-terminus) (By similarity).

    Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene

    Alternative splice isoforms for HSP90AA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSP90AA1 Gene

Protein Expression for HSP90AA1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HSP90AA1 Gene

  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
  • Ubiquitinated via Lys-63-linked polyubiquitination by HECTD1. Ubiquitination promotes translocation into the cytoplasm away from the membrane and secretory pathways.
  • Ubiquitination at isoforms=284, posLast=294294, posLast=314314, isoforms=2419, isoforms=2436, posLast=446446, posLast=478478, and posLast=513513

Other Protein References for HSP90AA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSP90AA1 Gene

Domains & Families for HSP90AA1 Gene

Gene Families for HSP90AA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for HSP90AA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HSP90AA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P07900

UniProtKB/Swiss-Prot:

HS90A_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA1: view

Function for HSP90AA1 Gene

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  2. CRISPR
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  4. Inhibitory RNA
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Molecular function for HSP90AA1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=300 uM for ATP {ECO:0000269 PubMed:18400751};
UniProtKB/Swiss-Prot EnzymeRegulation:
In the resting state, through the dimerization of its C-terminal domain, HSP90 forms a homodimer which is defined as the open conformation. Upon ATP-binding, the N-terminal domain undergoes significant conformational changes and comes in contact to form an active closed conformation. After HSP90 finishes its chaperoning tasks of assisting the proper folding, stabilization and activation of client proteins under the active state, ATP molecule is hydrolyzed to ADP which then dissociates from HSP90 and directs the protein back to the resting state.
UniProtKB/Swiss-Prot Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385).

Phenotypes From GWAS Catalog for HSP90AA1 Gene

Gene Ontology (GO) - Molecular Function for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 11470816
GO:0003723 RNA binding HDA,IDA 22658674
GO:0004713 protein tyrosine kinase activity EXP 17349580
GO:0005515 protein binding IPI 9660753
GO:0005524 ATP binding TAS,IEA 11470816
genes like me logo Genes that share ontologies with HSP90AA1: view
genes like me logo Genes that share phenotypes with HSP90AA1: view

Animal Models for HSP90AA1 Gene

MGI Knock Outs for HSP90AA1:

Animal Model Products

miRNA for HSP90AA1 Gene

miRTarBase miRNAs that target HSP90AA1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene

Localization for HSP90AA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Nucleus. Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSP90AA1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytosol 5
lysosome 5
mitochondrion 3
endoplasmic reticulum 3
cytoskeleton 2
golgi apparatus 2
endosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,ISS --
genes like me logo Genes that share ontologies with HSP90AA1: view

Pathways & Interactions for HSP90AA1 Gene

genes like me logo Genes that share pathways with HSP90AA1: view

SIGNOR curated interactions for HSP90AA1 Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006457 protein folding IEA --
GO:0006839 mitochondrial transport TAS 12526792
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with HSP90AA1: view

Drugs & Compounds for HSP90AA1 Gene

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(145) Drugs for HSP90AA1 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifabutin Approved, Investigational Pharma Target, other/unknown 58
Nedocromil Approved, Investigational Pharma Target 5
Copper Approved, Investigational Pharma Target 202
Geldanamycin Experimental, Investigational Pharma Target Hsp90 inhibitor,potent and specific, Selective Hsp90 inhibitor 0
Radicicol Experimental Pharma ATPase/kinase inhibitor, Hsp90 inhibitor. Antifungal antibiotic 0

(49) Additional Compounds for HSP90AA1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7

(4) Tocris Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor 75747-14-7
Geldanamycin Selective Hsp90 inhibitor 30562-34-6
KRIBB11 HSF1 inhibitor 342639-96-7
Radicicol Hsp90 inhibitor. Antifungal antibiotic 12772-57-5

(29) ApexBio Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG (KOS953) Hsp90 inhibitor 75747-14-7
17-AAG Hydrochloride Hsp90 inhibitor,geldanamycin analogue 911710-03-7
17-DMAG (Alvespimycin) HCl Hsp90 inhibitor 467214-21-7
Alvespimycin Hsp90 inhibitor,potent and selective 467214-20-6
AT13387 Hsp90 inhibitor 912999-49-6
AUY922 (NVP-AUY922) Potent Hsp90 inhibitor 747412-49-3
BIIB021 Hsp90 inhibitor,selective and competitive 848695-25-0
CH5138303 959763-06-5
EC 144 911397-80-3
Ganetespib (STA-9090) Hsp90 inhibitor,non-geldanamycin 888216-25-9
Gedunin naturally occurring Hsp90 inhibitor 2753-30-2
Geldanamycin Hsp90 inhibitor,potent and specific 30562-34-6
HSP990 (NVP-HSP990) 934343-74-5
IPI-504 (Retaspimycin hydrochloride) Hsp90 inhibitor,novel, potent,selective 857402-63-2
KNK437 stress-induced HSP synthesis inhibitor 218924-25-5
KW-2478 Potent Hsp90 inhibitor, novel, non-ansamycin, 819812-04-9
Macbecin I 73341-72-7
MPC-3100 Hsp90 inhibitor 958025-66-6
NMS-E973 Hsp90 inhibitor,potent and selective 1253584-84-7
NVP-BEP800 Oral Hsp90β inhibitor, novel, fully synthetic 847559-80-2
PF-04929113 (SNX-5422) Hsp90 inhibitor,potent and selective 908115-27-5
PU-H71 Hsp90 inhibitor,potent and selective 873436-91-0
PU-WS13 Grp94-specific Hsp90 inhibitor 1454619-14-7
Radicicol ATPase/kinase inhibitor 12772-57-5
Retaspimycin HSP90 inhibitor,antiproliferative and antineoplastic 857402-23-4
SNX-2112 Hsp90 inhibitor,ATP-competitve,potent and selective 908112-43-6
VER-49009 558640-51-0
VER-50589 747413-08-7
XL-888 Hsp90 inhibitor 1149705-71-4
genes like me logo Genes that share compounds with HSP90AA1: view

Drug Products

Transcripts for HSP90AA1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for HSP90AA1 Gene

(3) REFSEQ mRNAs :
(21) Additional mRNA sequences :
(2627) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSP90AA1 Gene

Heat shock protein 90kDa alpha (cytosolic), class A member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HSP90AA1 Gene

GeneLoc Exon Structure for
HSP90AA1
ECgene alternative splicing isoforms for
HSP90AA1

Expression for HSP90AA1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSP90AA1 Gene

mRNA expression in normal human tissues for HSP90AA1 Gene
mRNA expression by GTEx for HSP90AA1 GenemRNA expression by BioGPS for HSP90AA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSP90AA1 Gene

This gene is overexpressed in Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSP90AA1 Gene



Protein tissue co-expression partners for HSP90AA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSP90AA1 Gene:

HSP90AA1

SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene:

Hs.525600

Evidence on tissue expression from TISSUES for HSP90AA1 Gene

  • Liver(5)
  • Nervous system(5)
  • Blood(4.9)
  • Heart(4.9)
  • Lung(4.9)
  • Skin(4.9)
  • Intestine(4.8)
  • Kidney(4.8)
  • Eye(4.6)
  • Pancreas(4.5)
  • Stomach(4.3)
  • Bone(4.2)
  • Muscle(4.1)
  • Spleen(3.5)
  • Adrenal gland(3.1)
  • Bone marrow(3)
  • Lymph node(3)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with HSP90AA1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSP90AA1 Gene

Orthologs for HSP90AA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HSP90AA1 33 34
  • 99.18 (n)
oppossum
(Monodelphis domestica)
 Mammalia HSP90AA1 34
  • 97 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia HSP90AA1 34
  • 95 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hsp90aa1 33
  • 90.89 (n)
mouse
(Mus musculus)
 Mammalia Hsp90aa1 33 16 34
  • 90.12 (n)
cow
(Bos Taurus)
 Mammalia HSP90AA1 33 34
  • 88.62 (n)
dog
(Canis familiaris)
 Mammalia HSP90AA1 33 34
  • 87.47 (n)
chicken
(Gallus gallus)
 Aves HSP90AA1 33 34
  • 82.01 (n)
lizard
(Anolis carolinensis)
 Reptilia HSP90AA1 34
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hsp90aa1.1 33
  • 79.83 (n)
zebrafish
(Danio rerio)
 Actinopterygii hsp90aa1.2 33 34
  • 77.44 (n)
-- 33
fruit fly
(Drosophila melanogaster)
 Insecta Hsp83 34
  • 78 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea daf-21 34
  • 77 (a)
 OneToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HSP82 34
  • 61 (a)
 OneToMany
HSC82 36
thale cress
(Arabidopsis thaliana)
 eudicotyledons HSP81-2 33
  • 67.96 (n)
rice
(Oryza sativa)
 Liliopsida Os09g0482100 33
  • 66.43 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.11103 34
  • 79 (a)
 OneToMany
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.3846 33
Species where no ortholog for HSP90AA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSP90AA1 Gene

ENSEMBL:
Gene Tree for HSP90AA1 (if available)
TreeFam:
Gene Tree for HSP90AA1 (if available)

Paralogs for HSP90AA1 Gene

Paralogs for HSP90AA1 Gene

(14) SIMAP similar genes for HSP90AA1 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for HSP90AA1 Gene

genes like me logo Genes that share paralogs with HSP90AA1: view

Variants for HSP90AA1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AA1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000055689 -- 102,139,847(-) G/A upstream_transcript_variant
rs1000062529 -- 102,110,873(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000100990 -- 102,116,518(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000151696 -- 102,096,101(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000176361 -- 102,108,647(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HSP90AA1 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV loss 17160897
esv25342 CNV loss 19812545
esv2670326 CNV deletion 23128226
esv3552074 CNV deletion 23714750
esv3635541 CNV loss 21293372
esv3635542 CNV loss 21293372
esv3635543 CNV loss 21293372
nsv1113674 CNV deletion 24896259
nsv1131163 CNV deletion 24896259
nsv1428 CNV insertion 18451855
nsv565947 CNV gain 21841781
nsv832879 CNV loss 17160897
nsv976371 CNV duplication 23825009
nsv983856 CNV duplication 23825009

Variation tolerance for HSP90AA1 Gene

Residual Variation Intolerance Score: 3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HSP90AA1 Gene

Human Gene Mutation Database (HGMD)
HSP90AA1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSP90AA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Disorders for HSP90AA1 Gene

MalaCards: The human disease database

(24) MalaCards diseases for HSP90AA1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
epidermolysis bullosa acquisita
  • acquired epidermolysis bullosa
hypersensitivity reaction type iii disease
  • immune complex disease
hand-foot-genital syndrome
  • hfg
candidiasis
  • disseminated candidiasis
lobular neoplasia
  • lobular carcinoma in situ
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HSP90AA1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HSP90AA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene

Publications for HSP90AA1 Gene

  1. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PMID: 19875381) Gano JJ … Simon JA (Molecular & cellular proteomics : MCP 2010) 3 4 22 58
  2. Hsp90 is regulated by a switch point in the C-terminal domain. (PMID: 19696785) Retzlaff M … Buchner J (EMBO reports 2009) 3 4 22 58
  3. Conserved conformational changes in the ATPase cycle of human Hsp90. (PMID: 18400751) Richter K … Buchner J (The Journal of biological chemistry 2008) 3 4 22 58
  4. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PMID: 16269234) Chen B … Monteiro A (Genomics 2005) 2 3 4 58
  5. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PMID: 15937123) Martínez-Ruiz A … Lamas S (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 22 58

Products for HSP90AA1 Gene