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HSP90AA1 Gene

protein-coding   GIFtS: 70
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
  See HSP90AA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene:
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and lobular neoplasia. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search Chromatin IP Primers for HSP90AA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
102,547,075 bp from pter      End:
102,606,086 bp from pter
Size:
59,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1,
HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with
AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for
correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts
with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding
motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
Selected PDB 3D structures from and Proteopedia for HSP90AA1 (see all 166):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • Ubiquitination2 at Lys58, Lys74, Lys84, Lys112, Lys153, Lys185, Lys191, Lys209, Lys224, Lys283,
                                 Lys292, Lys294, Lys314, Lys327, Lys362, Lys407, Lys419, Lys436, Lys443, Lys446 (see all 27)
  • Modification sites at PhosphoSitePlus

  • See HSP90AA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900

    HSP90AA1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1
    OriGene Custom Protein Services for HSP90AA1
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    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSP90AA1 

     
    antibodies-online proteins for HSP90AA1 (11 products) 

     
    antibodies-online peptides for HSP90AA1

    HSP90AA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
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    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 (P08238, P07900)
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    ThermoFisher Antibody for HSP90AA1
    antibodies-online antibodies for HSP90AA1 (168 products) 

    HSP90AA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for HSP90AA1 
    antibodies-online kits for HSP90AA1 (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family


    Find genes that share domains with HSP90AA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding ----
    GO:0002135CTP binding ----
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI12526792
         
    Find genes that share ontologies with HSP90AA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with HSP90AA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       genOway: Develop your customized and physiologically relevant rodent model for HSP90AA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSP90AA1:
    hsa-mir-25-3p (MIRT050304), hsa-mir-30c-5p (MIRT047953), hsa-mir-30e-5p (MIRT044155), hsa-mir-186-5p (MIRT045178), hsa-mir-183-5p (MIRT047124), hsa-mir-421 (MIRT039416), hsa-mir-501-5p (MIRT041140), hsa-mir-378a-3p (MIRT043944), hsa-mir-3943 (MIRT052896), hsa-let-7b-5p (MIRT052238), hsa-mir-324-3p (MIRT042829), hsa-mir-425-5p (MIRT039331), hsa-mir-484 (MIRT041642), hsa-mir-204-5p (MIRT047015), hsa-mir-222-3p (MIRT046648), hsa-mir-1226-3p (MIRT036428), hsa-mir-16-5p (MIRT031959), hsa-mir-375 (MIRT020063), hsa-mir-760 (MIRT036729), hsa-mir-185-5p (MIRT045325), hsa-mir-17-5p (MIRT050979), hsa-mir-10a-5p (MIRT047507)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:
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    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HS90A_HUMAN, P07900: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    endoplasmic reticulum3
    nucleus3
    chloroplast2
    cytoskeleton2
    endosome2
    extracellular2
    mitochondrion2
    vacuole2
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSP90AA1 About   (see all 58)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    3Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82
    vRNP Assembly0.00
    4Metabolism of nitric oxide
    eNOS activation0.00
    eNOS activation and regulation0.00
    Metabolism of nitric oxide
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.00
    5Signaling by FGFR
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with HSP90AA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    Selected BioSystems Pathways for HSP90AA1 (see all 20)
        NOD pathway
    EBV LMP1 signaling
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway


    Selected Reactome Pathways for HSP90AA1 (see all 15)
        vRNP Assembly
    HSF1-dependent transactivation
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Scavenging by Class F Receptors
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration ----
    GO:0003009skeletal muscle contraction ----
    GO:0006200ATP catabolic process IDA15937123

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AA1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    Selected DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)



    Find genes that share compounds with HSP90AA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1
    Clone
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    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    Selected DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    Selected AceView cDNA sequences (see all 2627):

    BP354234 BM839745 BG393826 BQ685380 BX438647 BP357786 CR623660 CD358934 
    BM833745 BU581404 BM771323 BM770685 BP429471 BM771415 BM745750 BM792103 
    BM557327 BP363023 BM770054 BP365062 BU145598 BM818131 AI015385 BP363421 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTAGTCCT
    HSP90AA1 Expression
    About this image


    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Tooth (Integumentary System)
             Dental Enamel
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525600
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
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    QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.12(n)1
    98.77(a)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.01(n)
    95.6(a)
      423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSP90AA16
    heat shock protein 90kDa alpha (cytosolic), class ...
    82(a)
    1 ↔ 1
    GL343742.1(74458-74844)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsp90aa1.11 heat shock protein 90kDa alpha (cytosolic), class A more 79.83(n)
    93.26(a)
      549036  NM_001016282.2  NP_001016282.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    78(a)
    1 → many
    3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-216
    Protein DAF-21 (daf-21) mRNA, complete cds
    77(a)
    1 → many
    V(14684918-14688543) WBGene00000915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4 Cytoplasmic chaperone of the Hsp90 family, redundant more   --   13(632355-634472) 855224  NP_013911.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP81-21 HSP81-2 67.96(n)
    71.47(a)
      835701  NM_124985.4  NP_200414.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04821001 Os09g0482100 66.43(n)
    71.65(a)
      4347402  NM_001070035.1  NP_001063500.1 


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HSP90AA1 gene
    HSP90AB12  
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    Find genes that share paralogs with HSP90AA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HSP90AA1 (see all 1394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679323211,2
    C--82751808(+) TTTTT-/TT/TTT
            
    GAGAC
    1 -- int11NA 2
    rs556835511,2
    C--83556227(+) TTTTT-/TTT/TT
    TT
    /TTTTT
    GTGAC
    1 -- int11NA 2
    rs22774661,2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------
    rs10596291,2
    C,F,H--102547105(-) CTGTGC/TTAAAT 2 -- ut3123Minor allele frequency- T:0.10NA NS EA WA CSA 1791
    rs1506053111,2
    C--102547184(+) GGGATC/GCATGT 2 -- ut310--------
    rs1897916271,2
    --102547203(+) TTCCTA/GTTTTC 2 -- ut310--------
    rs10596231,2
    C,F,H--102547218(-) GCACAT/CGTAGG 2 -- ut3115Minor allele frequency- C:0.17MN NA WA CSA EA 561
    rs1813965301,2
    --102547222(+) CGTGTA/GCTCCA 2 -- ut310--------
    rs1869474781,2
    C--102547236(+) CACACA/CTGCTG 2 -- ut310--------
    rs1155148981,2
    C,F--102547305(+) GCTAGC/TGCCTC 2 -- ut311Minor allele frequency- T:0.05WA 118
    rs347676311,2
    F--102547331(-) ATGACAGTT/-  
            
    AGTGC
    2 -- ut312Minor allele frequency- -:0.04NS 88
    rs342870311,2
    C--102547373(-) GTGACA/CGTGTC 2 -- ut312Minor allele frequency- C:0.01NS 94
    rs1497792811,2
    --102547398(+) CTCATC/TTGTAT 2 -- ut310--------
    rs115475451,2
    C,F--102547461(+) GACTGG/AGTCTG 2 -- ut31 ese34Minor allele frequency- A:0.01NS NA 98
    rs1901377201,2
    --102547480(+) TTGAAC/TAGCTT 2 -- ut310--------
    rs357546581,2
    C,F--102547488(-) ATATCG/ATAAAG 2 -- ut312Minor allele frequency- A:0.01NS 94
    rs1862900631,2
    --102547490(+) TTACGA/TTATGC 2 -- ut310--------
    rs1911177711,2
    --102547491(+) TACGAC/TATGCT 2 -- ut310--------
    rs115475311,2
    C,F--102547602(-) AGTCCT/CCTAGA 2 -- ut31 ese35Minor allele frequency- C:0.04NA NS 100
    rs10580781,2
    C,F,A,H--102547648(-) CTTTTT/CGAACT 2 -- ut3117Minor allele frequency- C:0.06MN NS EA NA CSA WA 1369
    rs1440764021,2
    C--102547666(+) TACAAA/GATGTA 2 -- ut310--------
    rs1821395101,2
    --102547671(+) GATGTA/GACGAA 2 -- ut310--------
    rs1156905631,2
    C,F--102547712(+) AACACT/GTCAAT 2 -- ut311Minor allele frequency- G:0.04WA 118
    rs22988781,2
    C,F,H--102547745(-) CAAGCC/TGGATG 2 -- ut31 ese313Minor allele frequency- T:0.07EA NA NS 2518
    rs38314881,2
    C,F--102547769(-) TTGTGTG/-GTCTA 2 -- ut313Minor allele frequency- -:0.44NS NA 96
    rs725208761,2
    C--102547770(+) AGACC-/AC/CA 
            
    ACAAA
    4 -- ut312CSA 4
    rs2002205511,2
    C--102547774(-) TAACTG/TTGTGG 2 -- ut310--------
    rs1464875651,2
    C--102547816(+) TTACCC/TCAATC 2 -- ut310--------
    rs1490518401,2
    --102547818(+) ACCCCA/CATCTG 2 -- ut310--------
    rs1860859341,2
    --102547874(+) TTTAGA/TGCCTA 2 -- ut310--------
    rs1161453881,2
    C,F--102547927(+) CCTTAA/TAGTAG 2 -- ut311Minor allele frequency- T:0.02WA 118
    rs357982241,2
    C--102548006(-) ACAATT/GCCTCT 2 -- ut313Minor allele frequency- G:0.07NS WA 212
    rs1124174931,2
    C--102548008(+) AGGAAC/TTGTAG 2 -- ut311Minor allele frequency- T:0.50CSA 2
    rs1430881061,2
    C--102548026(+) AACAGC/GTAAGT 2 -- ut310--------
    rs2022027351,2
    --102548033(+) AAGTCA/GTCCCT 2 -- ut310--------
    rs619993511,2
    C,F--102548079(+) GTGTCG/ATCATC 4 /D syn12Minor allele frequency- A:0.00NS NA 4612
    rs115475231,2
    C,F,H--102548151(-) ATTGAT/CGAAGA 4 /D syn120Minor allele frequency- C:0.02NS EA NA WA EU 7753
    rs1914129971,2
    C--102548161(+) TACCTA/GTTTCC 2 -- int10--------
    rs561803591,2
    C--102548206(+) AGCCAA/GCTATT 2 -- int10--------
    rs559603601,2
    C--102548221(+) TAATAC/TTCTTG 2 -- int10--------
    rs22988771,2
    C,F,A,H--102548224(-) AACCAA/GGAGTA 2 -- int136Minor allele frequency- N:0.00EA NA NS EU WA CSA 4965
    rs1831941661,2
    --102548263(+) GACATA/GTGAGT 2 -- int10--------
    rs1883010981,2
    --102548264(+) ACATAA/TGAGTC 2 -- int10--------
    rs1423311931,2
    C--102548300(+) GACCT-/TACTACTT 2 -- cds10--------
    rs347664451,2
    C,F--102548369(-) TTATCC/GAAACT 2 -- int12Minor allele frequency- G:0.02NS 94
    rs65758951,2
    C,F,H--102548384(+) AAGTTT/CACCAT 2 -- int114Minor allele frequency- C:0.13NS WA NA CSA EA 469
    rs800208501,2
    C--102548441(+) TATAAG/TGCTTA 2 -- int10--------
    rs562055161,2
    C--102548448(+) CTTACC/TCAGAC 4 S G mis11Minor allele frequency- T:0.00NA 4448
    rs115475241,2
    C,F--102548458(-) ATCAAA/GCTTGG 4 K syn14Minor allele frequency- G:0.00NA EU 6101
    rs1146222521,2
    C,F--102548470(+) ATCCTG/ATAGAT 4 /Y syn11Minor allele frequency- A:0.01EA 206
    rs360253501,2
    C,F--102548485(-) ACACAT/CGCTAA 4 /H syn16Minor allele frequency- C:0.01NS WA NA EU 6369
    rs355980571,2
    C,F--102548545(-) GTCATC/TTTGCT 4 I syn13Minor allele frequency- T:0.00NS NA 4642
    rs2002074321,2
    --102548638(+) TCCAGC/GTGTTT 4 H Q mis10--------
    rs346449981,2
    C,F--102548703(-) TGGAGA/CGAATC 4 R syn17Minor allele frequency- C:0.01NS NA EU 6261
    rs1918955901,2
    --102548740(+) GTGACA/TATACA 4 I syn10--------
    rs1147892301,2
    --102548780(+) CAACCA/GCCTGT 4 A V mis11Minor allele frequency- G:0.01NA 214
    rs347449201,2
    C,F,H--102548791(-) ACTTTT/CTGATT 2 -- int14Minor allele frequency- C:0.00NS NA 320
    rs1996564561,2
    C--102548795(+) AAAAAA/GTGATG 2 -- int10--------
    rs1442746741,2
    C--102548854(+) ATCTGC/TAGAAC 2 -- int10--------
    rs1829684431,2
    --102548945(+) TATAAC/TTTCAT 2 -- int10--------
    rs1876226671,2
    --102549142(+) TTAGTA/GGAGAC 2 -- int10--------
    rs1926477501,2
    --102549170(+) GCCAGA/GATGGT 2 -- int10--------
    rs349553311,2
    C,F--102549179(-) GAGATC/GGAGAC 2 -- int12Minor allele frequency- G:0.01NS 94
    rs108735301,2
    C,F,A,H--102549231(+) GATTGT/CAGGCG 2 -- int111Minor allele frequency- C:0.41NA NS WA CSA 117
    rs1893518771,2
    --102549236(+) CAGGCA/GTGAGC 2 -- int10--------
    rs107824951,2
    C,F,H--102549262(+) CACACG/AACATA 2 -- int115Minor allele frequency- A:0.21NA NS WA CSA EA 477
    rs1928912671,2
    --102549277(+) TCTGTC/TTTAAG 2 -- int10--------
    rs1845751521,2
    --102549281(+) TTTTAA/GGTTGA 2 -- int10--------
    rs1886805861,2
    --102549287(+) GTTGAA/GAACAT 2 -- int10--------
    rs2013773951,2
    C--102549337(+) TAGAAA/GTATCA 2 -- int10--------
    rs2007982581,2
    --102549354(+) AGGAAA/GTGCTG 2 -- int10--------
    rs1414091381,2
    C--102549395(+) AATATA/C/GTCTTT 6 D E mis1 syn11NA 4544
    rs360784841,2
    C,F--102549416(-) GAGAAC/TCTCTG 4 N syn13Minor allele frequency- T:0.00NS NA 4624
    rs2001690811,2
    C--102549435(+) TTTTTC/TTCTCT 4 K R mis10--------
    rs1815095561,2
    --102549436(+) TTTTTC/TCTCTT 4 K E mis10--------
    rs756307011,2
    C--102549461(+) TCTTCA/TTCATC 4 E D mis10--------
    rs1409412171,2
    F--102549481(+) TTCCAG/AGCCTT 4 /L syn11Minor allele frequency- A:0.00NA 4508
    rs115475431,2
    C--102549564(-) CTATAA/C/TGATTG 6 K T M mis11NA 4550
    rs1861494231,2
    C--102549611(+) AAGGCC/TGAGTT 4 S syn10--------
    rs360924451,2
    C,F--102549679(-) TTCTTA/GACTGT 2 -- int13Minor allele frequency- G:0.00NS EU 1415
    rs116282721,2
    H--102549825(+) CACCCA/CCAGAG 2 -- int10--------
    rs779710241,2
    F--102549826(+) ACCCAC/AAGAGC 2 -- int11Minor allele frequency- A:0.09WA 118
    rs71559731,2
    C,F,H--102549839(+) ACAAGG/ATTGTA 2 -- int135Minor allele frequency- A:0.08NS EA NA WA CSA EU 4280
    rs1894041881,2
    C--102549851(+) GAACGA/TCGTGT 2 -- int10--------
    rs2001060341,2
    --102549863(+) TGACTA/GTAACA 2 -- int10--------
    rs1820050671,2
    C--102549869(+) TAACAC/TAGTGT 2 -- int10--------
    rs71565291,2
    C,F--102549873(+) ATAGTG/ATTCTC 2 -- int17Minor allele frequency- A:0.06NS NA WA EA EU 1773
    rs2016788021,2
    --102549916(+) CTCCTC/TCATTC 4 K E mis10--------
    rs2013715401,2
    --102549941(+) TTGAGA/TGAAAC 4 S syn10--------
    rs1142593431,2
    C--102549968(+) GCAGAT/CGTGTA 4 /T syn11Minor allele frequency- C:0.01NA 214
    rs1404415711,2
    C,F--102549971(+) GATGTG/ATAGTA 4 /Y syn11Minor allele frequency- A:0.00NA 4538
    rs349134411,2
    C,F--102549983(-) GAGCTG/ATTAAG 4 /L syn15Minor allele frequency- A:0.01NS WA NA 5008
    rs784199961,2
    C,F--102550070(+) GAATTT/AAAAAA 2 -- int12Minor allele frequency- A:0.50NA 4
    rs2018114881,2
    --102550081(+) AAAAAA/CAAAAA 2 -- int10--------
    rs350775361,2
    C,F--102550086(-) TTAGTT/GTTTTT 2 -- int13Minor allele frequency- G:0.06NS WA 96
    rs2004877841,2
    --102550108(+) GGAAAA/CCTAAT 2 -- int10--------
    rs1995427661,2
    --102550113(+) ACTAAC/TGGTTA 2 -- int10--------
    rs341585041,2
    C,F--102550121(-) GGTGTA/GAATAA 2 -- int13Minor allele frequency- G:0.03NS WA 212
    rs2013152951,2
    --102550170(+) TGTAGC/TTCTCT 4 N S mis10--------
    rs1906217881,2
    C--102550172(+) TAGTTA/CTCTTT 4 E D mis10--------
    rs1132613801,2
    C,F--102550184(+) TCTTCC/TGCCAG 4 A syn15Minor allele frequency- T:0.01CSA WA NA EU 4463
    rs1809178721,2
    C--102550333(+) AAATAC/TAAACC 2 -- int10--------
    rs2008355611,2
    C,F--102550342(+) CCAAAT/CGCACT 2 -- int11Minor allele frequency- C:0.00EU 977
    rs1459897491,2
    --102550384(+) TAAACC/TCCCAA 2 -- int10--------
    rs355655171,2
    C,F--102550402(-) TTCAGG/ATTATC 2 -- int13Minor allele frequency- A:0.03NS WA 212
    rs1862434301,2
    --102550419(+) GGGACC/GTATTT 2 -- int10--------
    rs1901735471,2
    --102550516(+) AGCTGA/TTTTCA 2 -- int10--------
    rs37424291,2
    C,F,A,H--102550569(+) GTAGAA/GATGGG 2 -- int115Minor allele frequency- G:0.34NS EA NA WA CSA 531
    rs101351181,2
    C,F,H--102550572(+) gagatG/Agggtt 2 -- int19Minor allele frequency- A:0.03NS EA NA CSA 518
    rs1828396221,2
    --102550593(+) GCCCAA/GGCTGG 2 -- int10--------
    rs345431981,2
    C,F--102550704(-) CTGTCA/GCTGAT 2 -- int13Minor allele frequency- G:0.00NS EU 1415
    rs1180431581,2
    C--102550733(+) ATACTT/CACTCA 2 -- int12Minor allele frequency- C:0.00NA EU 1441
    rs49471,2
    C,F,A,H--102550803(-) AACAAT/CATCAA 4 /N syn1 ese325Minor allele frequency- C:0.32MN NA NS WA CSA EA EU 7470
    rs1874805971,2
    --102550824(+) CTGTTC/TTCAAA 4 E syn10--------
    rs1488615091,2
    C--102550941(+) CAATGC/TATTAT 2 -- int10--------
    rs756412141,2
    C--102550999(+) TGAAG-/ATCACCC 2 -- int10--------
    rs1159276571,2
    C,F--102551024(+) TTCACT/CGCCAA 4 /A syn13Minor allele frequency- C:0.01WA 558
    rs1908888681,2
    C--102551057(+) AAGCTC/TTTATA 4 K syn10--------
    rs1155668471,2
    C,F--102551063(+) TTATAG/AAATTC 4 /F syn11Minor allele frequency- A:0.01WA 216
    rs1155139131,2
    C--102551072(+) TCTCCG/ATACTC 4 /Y syn12Minor allele frequency- A:0.00NA 4726
    rs1154575061,2
    --102551083(+) CTCATT/GAGTAA 4 /N /H mis11Minor allele frequency- G:0.01EU 118
    rs1414946801,2
    C,F--102551105(+) TTTCTG/AGTCCA 4 /T syn12Minor allele frequency- A:0.00NA EU 5873
    rs557938091,2
    C,F--102551163(+) TAATCT/ATCTTC 4 /K /M mis12Minor allele frequency- A:0.00WA NA 4760
    rs1999038351,2
    C--102551244(+) CTTCCA/GACTCT 4 S L mis10--------
    rs557834281,2
    C--102551262(+) CTTTTC/TCTTTT 4 E G mis10--------
    rs38329311,2
    C--102551276(+) tcttc-/TTTgtctt 2 -- cds10--------
    rs1473262211,2
    C,F--102551324(+) TCACGT/CTCCTT 4 /E syn11Minor allele frequency- C:0.00NA 4080
    rs1131722761,2
    C--102551336(+) TCCACA/C/GTTCAA 2 -- spa11CSA 1
    rs1418199611,2
    C--102551359(+) AATCAC/TATCAC 2 -- int10--------
    rs1921400021,2
    C--102551361(+) TCACAC/TCACTG 2 -- int10--------
    rs3771779541,2
    C--102551386(+) TAAGCA/GACAGC 2 -- int10--------
    rs1845645441,2
    C--102551597(+) ACCTAC/TAGACA 2 -- int10--------
    rs1471094891,2
    C--102551775(+) TGCAAA/GAGAAG 2 -- int10--------
    rs3705108911,2
    C--102551777(+) CAAGAA/C/GAAGAA 2 -- int10--------
    rs1385693771,2
    --102551783(+) AAGAAA/GGAAAA 2 -- int10--------
    rs45863641,2
    C,F--102551788(+) AGAAAA/GATTGA 2 -- int1 trp33Minor allele frequency- G:0.05NS EU 1407
    rs353089301,2
    C,F--102551795(-) TATTATTA/-AGTCA 2 -- cds12Minor allele frequency- -:0.06NS 90
    rs1459327081,2
    C--102551796(+) GACTT-/TAAAATAC 2 -- cds10--------
    rs599975741,2
    C--102551797(+) TAATA-/ATACATTC 2 -- cds10--------
    rs775368741,2
    C--102551801(+) TAATAA/CATTCA 2 -- int10--------
    rs1410421981,2
    --102551854(+) TATAAA/TGCAAG 2 -- int10--------
    rs351552491,2
    C,F--102551929(-) GCGGTT/CCTTTT 2 -- int13Minor allele frequency- C:0.08NS NA 214
    rs345961361,2
    C,F--102551949(-) GTAATG/TGCATG 2 -- int12Minor allele frequency- T:0.01NS 94
    rs341473141,2
    C,F--102551950(-) TGTAAT/GGGCAT 2 -- int12Minor allele frequency- G:0.01NS 94
    rs354881621,2
    C,F--102551955(-) ATTAGT/CGTAAT 2 -- int12Minor allele frequency- C:0.01NS 94
    rs557452021,2
    C,F--102551985(+) CTGATC/TGTTGG 2 -- int11Minor allele frequency- T:0.05EA 120
    rs340146621,2
    C,F--102552000(-) AGAATT/ATGTGT 2 -- int12Minor allele frequency- A:0.01NS 94
    rs352417781,2
    C,F--102552030(-) TTGGAC/TCCCTG 2 -- int13Minor allele frequency- T:0.07NS NA 214
    rs1892352491,2
    C--102552077(+) CCAGTG/TAATGT 2 -- int10--------
    rs2018768741,2
    C--102552089(+) CAGGTG/ACCTAC 2 -- int11Minor allele frequency- A:0.00EU 1323
    rs1159674661,2
    --102552106(+) CTGTCC/TTCACT 4 K R mis11Minor allele frequency- T:0.01NA 214
    rs1156746121,2
    C,F--102552132(+) GCTGAG/AGACTC 4 /S syn13Minor allele frequency- A:0.00EU NA 5917
    rs1485543421,2
    F--102552144(+) CAAGCG/ATACTG 4 /Y syn11Minor allele frequency- A:0.00NA 4538
    rs1511606001,2
    C--102552306(+) CCAAGG/ATTATT 4 /N syn11Minor allele frequency- A:0.00NA 4546
    rs1390519481,2
    C,F--102552359(+) AGTGAG/AAGTTC 4 /L /F mis11Minor allele frequency- A:0.00NA 4548
    rs1162852491,2
    --102552447(+) TACCGG/AATTTT 4 /I syn11Minor allele frequency- A:0.01WA 218
    rs1853846961,2
    C--102552472(+) AACAAA/GAAATA 2 -- int10--------
    rs2011325421,2
    C--102552483(+) TTAATT/CTAAGC 2 -- int11Minor allele frequency- C:0.00EU 973
    rs1493782581,2
    C,F--102552490(+) AAGCAT/CACAGC 2 -- int11Minor allele frequency- C:0.00EU 1013
    rs38309651,2
    C--102552502(-) AACTT-/CTTGGGGG 2 -- int10--------
    rs1462941481,2
    C--102552537(+) TCTGGA/C/GTTAAT 2 -- int10--------
    rs1164761891,2
    C,F--102552587(+) AGAAAG/AATCTC 4 /I syn12Minor allele frequency- A:0.01EA NA 430
    rs2014075911,2
    C--102552644(+) ATTTCC/TGCCTG 4 A syn10--------
    rs115475381,2
    C,F--102552656(-) ACGTTA/C/TGCCTT 6 L F mis1 syn11NA 4550
    rs1411591611,2
    C--102552684(+) CCATCG/AGTTGG 4 /P /L mis11Minor allele frequency- A:0.00NA 4548
    rs1807470511,2
    C--102552722(+) TGGAAC/GGACAC 2 -- int10--------
    rs2004211401,2
    --102552743(+) TAAAAA/CCTTGC 2 -- int10--------
    rs347217981,2
    C--102552759(-) CCTCTG/CTAGAC 2 -- int12Minor allele frequency- C:0.01NS 94
    rs80046401,2
    C,F,A--102552773(+) CACGAG/AATTCC 2 -- int19Minor allele frequency- A:0.09NS WA NA CSA EA 460
    rs37368071,2
    C,F,H--102552775(-) ATGGAC/ATTTCG 2 -- int122Minor allele frequency- A:0.32EA NS NA CSA WA 3915
    rs361126651,2
    C,F--102552856(-) TTTGTC/TAGCCG 2 -- int13Minor allele frequency- T:0.03NS NA 212
    rs1852143871,2
    C--102552932(+) AGGCCC/TGGGCC 2 -- int10--------
    rs619924891,2
    C--102553167(+) AGCGGG/TCCCGA 2 -- int13Minor allele frequency- T:0.16NA 124
    rs1900328101,2
    --102553180(+) CCTCCA/GGAATA 2 -- int10--------
    rs1173399561,2
    C,F--102553255(+) CTCCGC/TCCCGC 2 -- int11Minor allele frequency- T:0.12EA 120
    rs123237551,2
    --102553279(+) AGTCCC/TGGTCC 2 -- int10--------
    rs1858206101,2
    --102553303(+) ACAGGC/TCCCCA 2 -- int10--------
    rs175544231,2
    F--102553350(-) GTGCCG/ATTGGT 2 -- int1 ut512Minor allele frequency- A:0.01MN EA 356
    rs1116773201,2
    C--102553355(+) CGGCAC/GAGCCA 2 -- int1 ut510--------
    rs22736551,2
    F--102553364(-) GTCCCG/AGTGTG 2 -- int1 ut511Minor allele frequency- A:0.03EA 1272
    rs414387441,2
    C,F--102553414(+) ATAGCG/CACGGG 2 -- int1 ut513Minor allele frequency- C:0.10NA CSA WA 122
    rs1428001991,2
    --102553490(+) GCCGCA/CGCGGC 2 -- int1 ut510--------
    rs175257341,2
    C--102553626(-) CGCGGC/GGGCGT 2 -- int1 us2k10--------
    rs1487038911,2
    C--102553683(+) GGCGCC/TTTCTG 2 -- int1 us2k10--------
    rs175235051,2
    C,F--102553841(-) CGCACG/TACCCT 2 -- int1 us2k13Minor allele frequency- T:0.04MN EA WA 474
    rs1421623451,2
    --102553844(+) GTCGTC/GCGTGG 2 -- int1 us2k10--------
    rs1507747091,2
    --102553852(+) TGGACC/GGAGAG 2 -- int1 us2k10--------
    rs1114826271,2
    C,F--102553906(+) CCTGAG/CTGGCG 2 -- int1 us2k11Minor allele frequency- C:0.50NA 2
    rs1903279781,2
    --102553927(+) TGCCAA/GAGAAT 2 -- int1 us2k10--------
    rs1836870341,2
    --102554034(+) CGCTCA/GGGGAT 2 -- int1 us2k10--------
    rs1154523531,2
    C--102554040(+) GGGATC/TCTCCA 2 -- int1 us2k10--------
    rs1886557121,2
    --102554124(+) CCTTAC/GCTTGG 2 -- int1 us2k10--------
    rs116236051,2
    C,H--102554286(+) TTTTTC/TTCTTT 2 -- int1 us2k1 trp32Minor allele frequency- T:0.25NA CSA 4
    rs561158401,2
    C--102554288(+) TTTTTC/TTTTTT 2 -- int1 us2k10--------
    rs601824731,2
    C,F--102554345(+) GCGGCG/AGAATC 2 -- int1 us2k12Minor allele frequency- A:0.05WA 120
    rs1475969461,2
    --102554394(+) ATCCTC/TCCGCC 2 -- int1 us2k10--------
    rs1169372051,2
    C,F--102554410(+) TTTCCC/AAGTAG 2 -- int1 us2k11Minor allele frequency- A:0.08NA 120
    rs726985211,2
    C,F--102554449(+) GGCGCG/CGACAC 2 -- int1 us2k11Minor allele frequency- C:0.03NA 120
    rs2019259261,2
    C--102554456(+) GACAC-/ACACCT 2 -- int1 us2k10--------
    rs49061781,2
    C,F,A,H--102554552(+) GATATC/TTTGGC 2 -- int1 us2k124Minor allele frequency- T:0.28NS EA NA WA CSA 2351
    rs1402725661,2
    C--102554634(+) TCTTCC/TTCTTT 2 -- int1 us2k10--------
    rs1442506731,2
    C--102554721(+) CTTGCC/GGTGTA 2 -- int1 us2k10--------
    rs1923557041,2
    --102554739(+) GATGGA/CACTAC 2 -- int1 us2k10--------
    rs1166284281,2
    C,F--102554753(+) CGCTTC/TCTGGT 2 -- int1 us2k11Minor allele frequency- T:0.02WA 118
    rs49061791,2
    C,F,A,H--102554761(+) GGTCTC/TTAGGG 2 -- int1 us2k119Minor allele frequency- T:0.09NS NA WA CSA EA 1840
    rs1454025121,2
    --102554790(+) AGCAGA/GGGTTT 2 -- int1 us2k10--------
    rs38093861,2
    C,F,A,H--102554791(-) AAAACG/CCCTGC 2 -- int1 us2k110Minor allele frequency- C:0.36NA WA CSA EA 371
    rs1825089041,2
    --102554831(+) CGTGTA/GAAATC 2 -- int1 us2k10--------
    rs1869024421,2
    --102554900(+) CACGTA/GGCGCG 2 -- int1 us2k10--------
    rs38093851,2
    C--102554925(-) ACACCC/GGGTCA 2 -- int1 us2k10--------
    rs1433171491,2
    --102554938(+) GCCTGC/GTCCTG 2 -- int1 us2k10--------
    rs1917683511,2
    C--102554969(+) GGGGGC/TGCGCC 2 -- int1 us2k10--------
    rs1995101001,2
    C--102555018(-) ATTCCC/TCCCCG 2 -- int1 us2k10--------
    rs759815861,2
    F--102555178(+) CATTGC/TCCAGG 2 -- int1 us2k11Minor allele frequency- T:0.03WA 118
    rs2001939291,2
    --102555246(+) TTCTT-/TTCTTTTT 2 -- cds10--------
    rs2017183341,2
    --102555247(+) TCTTT-/TCTTTTT 2 -- int1 us2k10--------
    rs677922771,2
    C--102555249(+) TTTTT-/CTTTTT 2 -- int1 us2k10--------
    rs1128809501,2
    C--102555249(+) CTTTTC/TTTTTT 2 -- int1 us2k10--------
    rs1840080701,2
    --102555270(+) AAAGTC/TTCACT 2 -- int1 us2k10--------
    rs1999548221,2
    --102555312(+) AATCT-/CTGCTC
    ACTGCAAC
    CTGCT
    2 -- int1 us2k10--------
    rs1871859891,2
    --102555344(+) CCTCTA/GCCTCC 2 -- int1 us2k10--------
    rs1928502361,2
    --102555418(+) ACGCCC/TGGCTA 2 -- int1 us2k10--------
    rs101511881,2
    C,F,H--102555500(+) TGATCC/TGCCCG 2 -- int1 us2k11Minor allele frequency- T:0.03NS 118
    rs1456834361,2
    --102555593(+) GGACCG/TTCATT 1 -- int10--------
    rs1853514291,2
    --102555700(+) CCCTTC/TTTCCT 1 -- int10--------
    rs1427629481,2
    --102555707(+) TCCTTC/TCACAA 1 -- int10--------
    rs1903310051,2
    --102556034(+) GCTTCA/CCCCCT 1 -- int10--------
    rs1825045511,2
    --102556075(+) CAGGTC/TACTGA 1 -- int10--------
    rs1836214521,2
    --102556216(+) GTCAGC/TTCACC 1 -- int10--------
    rs1450239341,2
    --102556340(+) CCCACC/GCTCTG 1 -- int10--------
    rs1883222981,2
    --102556349(+) TGCAAA/GTTCTA 1 -- int10--------
    rs1386250731,2
    --102556405(+) TGTGAC/GGCCCT 1 -- int10--------
    rs1493254941,2
    --102556461(+) TCCTAC/TTTCTG 1 -- int10--------
    rs1445278901,2
    C--102556474(+) TCTGGC/TGCACT 1 -- int10--------
    rs793257091,2
    C,F--102556577(+) ATCTTC/TTGCTC 1 -- int11Minor allele frequency- T:0.03WA 118
    rs116215601,2
    C,F,A,H--102556743(+) TTCACA/CGCCTT 1 -- int136Minor allele frequency- C:0.40NS EA EU NA WA CSA 3929
    rs113316171,2
    C,F--102556810(+) AGACGG/-AGTCT 1 -- int14Minor allele frequency- -:0.50NA CSA 8
    rs1484505541,2
    C--102556869(+) ACAAGC/TTCCGC 1 -- int10--------
    rs1808651551,2
    --102556872(+) AGCTCC/TGCCTC 1 -- int10--------
    rs1436559201,2
    --102556879(+) CCTCCC/TGGGTT 1 -- int10--------
    rs1471650711,2
    --102556929(+) CTACAC/GGCGCC 1 -- int10--------
    rs1404414521,2
    --102556931(+) ACAGGC/TGCCCG 1 -- int10--------
    rs1441573731,2
    --102556936(+) CGCCCA/GCCACC 1 -- int10--------
    rs619924901,2
    F--102556947(+) ACACCC/TGGCTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1399589251,2
    --102556974(+) AAGTAC/GAGAGG 1 -- int10--------
    rs1501487581,2
    --102556997(+) GTTAGC/TCAGGA 1 -- int10--------
    rs1458847721,2
    --102557089(+) GGCCTC/TAACAA 1 -- int10--------
    rs1852685331,2
    --102557327(+) TTTCTA/GTGCAT 1 -- int10--------
    rs1899243881,2
    --102557339(+) CAGTTA/CAGTAT 1 -- int10--------
    rs1458467961,2
    --102557443(+) TACCCC/TATAGC 1 -- int10--------
    rs777870081,2
    C,F--102557484(+) AGCAGG/ACTAGC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1815186861,2
    --102557621(+) CTCCAC/GGGCAG 1 -- int10--------
    rs1871071791,2
    --102557636(+) ACCCAC/GGTCTG 1 -- int10--------
    rs1465748331,2
    C--102557783(+) GGTGAA/TACCCC 1 -- int10--------
    rs1179137301,2
    C,F--102557813(+) AAAAAT/GTTAGC 1 -- int11Minor allele frequency- G:0.08NA 120
    rs1413045201,2
    --102557846(+) TAGTCC/TCAGCT 1 -- int10--------
    rs2014733761,