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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90AA1 Gene

protein-coding   GIFtS: 69
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene: 
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and lobular neoplasia, and among its related super-pathways are NOD-like receptor signaling pathway and G2/M Transition. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSP90AA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
102,547,075 bp from pter      End:
102,606,086 bp from pter
Size:
59,012 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction,
together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex.
Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination
systems
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
stage I to stage IV
6/162 PDB 3D structures from and Proteopedia for HSP90AA1 (see all 162):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • UniProtKB: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07900

  • HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSP90AA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900
    Human Recombinant Protein Products for HSP90AA1: 
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    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins for HSP90AA1
    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1 
    OriGene Custom Protein Services for HSP90AA1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    HSP90AA1 for ontologies           About GeneDecksing



    HSP90AA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies for HSP90AA1
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    GenScript Custom Superior Antibodies Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1
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    ThermoFisher Antibody for HSP90AA1
    LSBio Antibodies in human, mouse, rat for HSP90AA1 

    Assay Products for HSP90AA1: 
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    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family


    HSP90AA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding IEA--
    GO:0002135CTP binding IEA--
    GO:0003729mRNA binding IEA--
    GO:0005515protein binding IPI12526792
         
    HSP90AA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    HSP90AA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSP90AA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSP90AA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSP90AA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSP90AA1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSP90AA1
    Sirion Biotech Customized adenovirus for overexpression of HSP90AA1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSP90AA1 (see all 14)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    Sirion Biotech Customized lentivirus for stable overexpression of HSP90AA1 
                         Customized lentivirus expression plasmids for stable overexpression of HSP90AA1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HSP90AA1
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSP90AA1 About   (see all 61)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    3Metabolism of nitric oxide
    Metabolism of nitric oxide0.59
    eNOS activation and regulation0.59
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.59
    eNOS activation0.41
    4Signaling by FGFR
    Signaling by ERBB20.90
    Signaling by EGFR in Cancer0.83
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for HSP90AA1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Selected targets of GCR-alpha
    Signal transduction AKT signaling

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    5/19 BioSystems Pathways for HSP90AA1 (see all 19)
        EBV LMP1 signaling
    NOD pathway
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway


    5/28        Reactome Pathways for HSP90AA1 (see all 28)
        Developmental Biology
    Metabolism
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation


    HSP90AA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1663 Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1663)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration IEA--
    GO:0003009skeletal muscle contraction IEA--
    GO:0006200ATP catabolic process IDA15937123

    HSP90AA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90AA1 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSP90AA1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    10/45 DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    10/113 Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Search CenterWatch for drugs/clinical trials and news about HSP90AA1 / HS90A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    24/224 DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    24/2627 AceView cDNA sequences (see all 2627):

    T16337 AA369744 BM751979 AA319049 BE772654 BM974105 BE793051 BI861290 
    BU153102 BM771890 BQ638075 BX444743 AI801059 CR607053 BM802957 BM456889 
    AA593911 BP354457 BP364931 AA309988 BM745750 BX429503 BC023006 BQ446823 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)      HSP90AA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTAGTCCT
    HSP90AA1 Expression
    About this image


    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             visceral organ/metanephros/renal cortex   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/metanephros/renal cortex   
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal

    See HSP90AA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSP90AA1

    SOURCE GeneReport for Unigene cluster: Hs.525600
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.3(n)1
    99.18(a)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.37(n)
    96.43(a)
      423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    HSP90AA16
    Uncharacterized protein
    96(a)
    82(a)
    possible ortholog
    1 ↔ 1
    GL343232.1(1912641-1921714)
    GL343742.1(74458-74844)
    zebrafish
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    78(a)
    1 → many
    3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-216
    Heat shock protein 90
    77(a)
    1 → many
    V(14684918-14688543)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4
    HSP821
    Cytoplasmic chaperone of the Hsp90 family, redundant more4
    Hsp82p1
    62.96(n)1
    64.05(a)1
      13(632355-634472)4
    8558361  NP_015084.11  8552244 
     NP_013911.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP90.11 heat shock protein 81-1 66.81(n)
    73.81(a)
      835341  NM_124642.3  NP_200076.1 


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90AA1 gene
    HSP90B12  TRAP12  HSP90AB12  
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN     Q96HX7_HUMAN     Q86U12_HUMAN     H0YJF5_HUMAN     Q8TBA7_HUMAN     G3V592_HUMAN     G3V2J8_HUMAN     Q2VPJ6_HUMAN(see first protein):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    HSP90AA1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1394 SNPs in HSP90AA1 are shown (see all 1394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679323211,2
    C--82751808(+) TTTTT-/TT/TTT
            
    GAGAC
    1 -- int11NA 2
    rs556835511,2
    C--83556227(+) TTTTT-/TTT/TT
    TT
    /TTTTT
    GTGAC
    1 -- int11NA 2
    rs22774661,2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSP90AA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670326CNV Deletion23128226
    nsv1428CNV Insertion18451855
    esv25342CNV Loss19812545
    nsv832879CNV Loss17160897
    dgv25n68CNV Loss17160897


    Human Gene Mutation Database (HGMD): HSP90AA1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140571    OMIM disorders: --

    20/128 diseases for HSP90AA1 (see all 128):    About MalaCards
    hand-foot-genital syndrome    lobular neoplasia    neuronal intranuclear inclusion disease    candidiasis
    atypical teratoid rhabdoid tumor    dopa-responsive dystonia    rhabdoid tumor    primary hyperoxaluria
    gastrointestinal stromal tumor    anaplastic large cell lymphoma    mixed cryoglobulinemia    varicocele
    testicular cancer    macroglobulinemia    cryoglobulinemia    polymyositis
    waldenstrom macroglobulinemia    dermatomyositis    rheumatic disease    peutz-jeghers syndrome

    3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    HSP90AA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Genetic Association Database (GAD): HSP90AA1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 9 sources (see all 1977):
    (articles sorted by number of sources associating them with HSP90AA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (1998)
    4. A proteomic investigation of ligand-dependent HSP90 c omplexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (1998)
    6. Hsp90 is regulated by a switch point in the C-termina l domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (2009)
    7. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A....Lamas S. (2005)
    8. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (2003)
    9. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (2009)
    10. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSP90AA1
    Customized:
     lentivirus for stable overexpression of HSP90AA1
     lentivirus expression plasmids for stable overexpression of HSP90AA1
     adenovirus for overexpression of HSP90AA1
     LSBio Antibodies in human, mouse, rat for HSP90AA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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