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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90AA1 Gene

protein-coding   GIFtS: 69
GCID: GC14M102547

heat shock protein 90kDa alpha (cytosolic), class A member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
 Explore 139 diseases affiliated with
HSP90AA1 via
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 Human Malady Compendium 
Biological research products
for HSP90AA1    

Aliases
for HSP90AA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     HSP 862 3
HSPC11 2 3 5     HSP89A2 5
HSPCA1 2 3 5     HSPCAL42 5
HSP90A2 3 5     LAP22 5
HSP90N1 2     FLJ318841
Hsp891 2     EL522
Hsp901 2     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Epididymis Luminal Secretory Protein 522
Heat Shock 86 KDa2 3     Heat Shock 90kD Protein 1, Alpha-Like 42
Renal Carcinoma Antigen NY-REN-382 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP862 3     Heat Shock Protein HSP 90-Alpha2

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


Summaries
for HSP90AA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSP90AA1:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein
aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Jan 2012)

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific
target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that
is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby
causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,
ATPase cycle and chaperone function

summary for HSP90AA1:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1)


Genomic Views
for HSP90AA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSP90AA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
 102,547,075 bp from pter      End:
 102,606,086 bp from pter
Size:
 59,012 bases      Orientation:
 minus strand

Proteins
for HSP90AA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together
with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1
and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I
to stage IV
6/159 PDB 3D structures from and Proteopedia for HSP90AA1 (see all 159):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Post-translational modifications:

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07900

    • HSP90AA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins (see all 2): HSP90AA1
    OriGene Protein Over-expression Lysate (see all 2): HSP90AA1
    OriGene Custom Protein Services for HSP90AA1 
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0042470melanosome IEA--


    HSP90AA1 for ontologies           About GeneDecksing



    HSP90AA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies (see all 5): HSP90AA1
    OriGene Custom Antibody Services for HSP90AA1 
    GenScript Custom Superior Antibodies Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for HSP90AA1

    Assay Products for HSP90AA1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSP90AA1
    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HSP90AA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSP90AA1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 ATPase-like_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein families:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone
    STUB1
    Similarity: Belongs to the heat shock protein 90 family


    Function
    for HSP90AA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific
    target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that
    is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby
    causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,
    ATPase cycle and chaperone function

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HSP90AA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1 (see all 7)
    OriGene shRNA RFP: HSP90AA1
    OriGene siRNA: HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSP90AA1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HSP90AA1
    Search LifeMap BioReagents cell lines for HSP90AA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0005515protein binding IPI--
    GO:0005524ATP binding TAS11470816
    GO:0016887ATPase activity IDA15937123
    GO:0030235nitric-oxide synthase regulator activity IDA15937123


    HSP90AA1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

    Animal Models:
         Mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon
         5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    HSP90AA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HSP90AA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/57 super-pathways (see all 57) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    		Development_Glucocorticoid receptor signaling0.27
    		CFTR folding and maturation (norm and CF)0.37
    		Development Glucocorticoid receptor signaling0.27
    3Metabolism of nitric oxide
    		Metabolism of nitric oxide1.00
    		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.59
    		eNOS activation and regulation1.00
    		eNOS activation0.41
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for HSP90AA1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Selected targets of GCR-alpha
    Signal transduction AKT signaling

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    5/19 BioSystems Pathways for HSP90AA1 (see all 19) 
        EBV LMP1 signaling
    NOD pathway
    TNF-alpha/NF-kB Signaling Pathway
    IL-6 Signaling Pathway
    IL-2 Signaling Pathway

    5/27        Reactome Pathways for HSP90AA1 (see all 27)
        Developmental Biology
    Metabolism
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    5/6         Kegg Pathways  (Kegg details for HSP90AA1) (see all 6):
        Protein processing in endoplasmic reticulum
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation
    Pathways in cancer


    HSP90AA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1596 Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP5CP530411, 2, 3, ENSP000000124434EBI-2211817,EBI-716663 MINT-8204116 MINT-8204092 I2D: score=12 STRING: ENSP00000012443
    RPS3AP612471, 2, 3, ENSP000003460504EBI-2211817,EBI-3440915 MINT-63931 I2D: score=5 STRING: ENSP00000346050
    MAP3K7O433182, 3, ENSP000003583354MINT-6797194 MINT-6797182 MINT-48032 MINT-6797216 MINT-6797232 MINT-49246 I2D: score=1 STRING: ENSP00000358335
    CDC37Q165432, 3, ENSP000002220054MINT-6797194 MINT-6797182 MINT-6797216 MINT-6797232 I2D: score=10 STRING: ENSP00000222005
    TAB1Q157502, 3, ENSP000002161604MINT-49177 MINT-6797194 MINT-6797216 I2D: score=2 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006200ATP catabolic process IDA15937123
    GO:0006457protein folding ----
    GO:0006839mitochondrial transport TAS12526792


    HSP90AA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSP90AA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90AA1 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSP90AA1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCT 018159Hsp90 inhibitor[171009-07-7]
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    Macbecin IHsp90 inhibitor[73341-72-7]
    GeduninHsp90 inhibitor; anticancer and antimalarial activity[2753-30-2]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    10/45 DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    10/113 Novoseek chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Search CenterWatch for drugs/clinical trials and news about HSP90AA1 / HS90A 

    Transcripts
    for HSP90AA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1 (see all 7)
    OriGene shRNA RFP: HSP90AA1
    OriGene siRNA: HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional cDNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 X07270.1 X15183.1 

    24/211 DOTS entries (see all 211):

    DT.100849252  DT.91781494  DT.100658316  DT.91845523  DT.100730414  DT.100730410  DT.100801571  DT.100730420 
    DT.95129185  DT.98131982  DT.100680135  DT.100730476  DT.100860129  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.120782168  DT.100846879  DT.97848044  DT.100662911  DT.95378226  DT.100730426  DT.97848122 

    24/2627 AceView cDNA sequences (see all 2627):

    CB124900 BM761115 BX438647 CB243663 BQ651916 BQ639882 BM472848 CA417925 
    BP361918 BM827359 BQ709040 BQ028824 BQ431360 BE328211 AA381831 AA313331 
    BP371203 BQ687650 CR593964 BI856817 AA234219 AA779056 BE501582 BE783147 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    Expression
    for HSP90AA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTAGTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HSP90AA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    LiverLiver LobuleLiver
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See HSP90AA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSP90AA1

    SOURCE GeneReport for Unigene cluster: Hs.525600
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    Orthologs
    for HSP90AA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HSP90AA1 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.3(n)1
    99.18(a)1    		   12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)    		 Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.37(n)
    96.43(a)    		   423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HSP90AA16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343232.1(1912641-1917038)
    zebrafish
    (Danio rerio)    		 Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hsp836
    		 Heat shock protein 83
    		 79(a)
    		 possible ortholog
    		 3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)    		 Secernentea daf-216
    		 Heat shock protein 90
    		 77(a)
    		 possible ortholog
    		 V(14684903-14688528)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HSC82(YMR186W)4
    HSP821    		 Cytoplasmic chaperone of the Hsp90 family, redundant more4
    Hsp82p1    		 62.96(n)1
    64.05(a)1    		   13(632355-634472)4
    8558361  NP_015084.11  8552244 
     NP_013911.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HSP90.11 heat shock protein 81-1 66.81(n)
    73.81(a)    		   835341  NM_124642.3  NP_200076.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 heat shock protein, putative, expressed
    (see all 9)    		 72(a)
    71(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 9(18513571-18517315)
    8(24716372-24720839)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria htpG6
    		 protein refolding molecular co-chaperone Hsp90, Hs...
    		 39(a)
    		 possible ortholog
    		 Chromosome(494344-496218)


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available) 

    Paralogs
    for HSP90AA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90AA1 gene
    HSP90B12  HSP90AB12  TRAP12  
    13 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    HSP90AB1    HSP90AA2    HSP90Be    HSP90B1    HSP90AB3P
    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1    HSP90Bf
    HSP90AB2P

    HSP90AA1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    Genomic Variants
    for HSP90AA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1163 NCBI SNPs in HSP90AA1 are shown (see all 1163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs22774661,2
    		C,F,H,--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    		C,F,H,--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    		C,F,H,--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    		C,F,H,--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    		--102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    		--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    		--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    		--102547092(+) ATTAAC/GTGACT 2 -- ut310--------
    rs10596291,2
    		C,F,H,--102547105(-) CTGTGC/TTAAAT 2 -- ut3123Minor allele frequency- T:0.10NA NS EA WA CSA 1791
    rs1506053111,2
    		--102547184(+) GGGATC/GCATGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HSP90AA1
         3 CNVs: 76736 66711 87364
         1 Indel: 87365
    Human Gene Mutation Database (HGMD): HSP90AA1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA1

    Disorders / Diseases
    for HSP90AA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSP90AA1 for disorders           About GeneDecksing

    OMIM gene information: 140571    OMIM disorders: --

    20/139 diseases for HSP90AA1 (see all 139):    About MalaCards
    hand-foot-genital syndrome    dopa-responsive dystonia    atypical teratoid rhabdoid tumor    renal carcinoma
    carcinoma    anaplastic large cell lymphoma    peutz-jeghers syndrome    neuronal intranuclear inclusion disease
    gastrointestinal stromal tumor    lichen planus    long qt syndrome    oral lichen planus
    waldenstrom macroglobulinemia    malignant pleural mesothelioma    non-hodgkin lymphoma    lobular neoplasia
    ataxia telangiectasia    rhabdoid tumors    amyotrophic lateral sclerosis    myasthenia gravis

    3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    91 Novoseek disease relationships for HSP90AA1 gene (see top 10)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)
    glioblastoma 23.4 9 11205288 (2), 16099423 (1), 17079230 (1), 20457619 (1) (see all 7)
    neurodegeneration 22.4 7 17185503 (1), 17536171 (1), 19090995 (1)
    neurofibrillary tangles 20.7 1 17032350 (1)
    solid tumor 20 4 16682002 (1), 17671112 (1), 18927314 (1), 16923571 (1) (see all 5)
    melanoma 17.4 40 15009113 (6), 18037622 (5), 15841378 (3), 17363539 (3) (see all 15)
    prostate carcinoma 12.2 5 18840695 (3), 16452239 (1), 18954528 (1)
    senile plaques 10.5 3 17032350 (1), 11919167 (1)
    ovarian carcinoma 7.65 4 12780528 (3), 19113837 (1)
    colon carcinoma 6.92 2 15735687 (1), 10674022 (1)
    anaplastic large cell lymphoma 6.34 4 17610208 (2), 17157164 (2)
    disseminated candidiasis 5.41 1 11566001 (1)
    atrophy 5.36 2 17185503 (1), 20348093 (1)
    lupus erythematosus systemic 4.87 9 17357483 (2), 9693973 (1), 1489490 (1), 11771959 (1) (see all 7)
    primary tumor 4.67 1 12633846 (1)
    metastasis 4.11 41 15009113 (4), 15810071 (2), 17645779 (2), 19598015 (2) (see all 27)
    hepatitis c 3.71 1 17024179 (1)
    gastrointestinal stromal tumor 3.4 4 19047110 (3), 19706776 (1)
    adenocarcinoma 3.27 4 17319785 (2), 15687592 (1), 19142186 (1)
    multiple sclerosis 2.88 7 18573821 (2)
    nsclc 2.63 20 18320023 (5), 12893076 (4), 16024644 (2), 20423228 (2) (see all 9)
    gastric cancer 2.54 4 17363505 (3), 18025273 (1)
    inflammation 2.38 13 17615388 (2), 17400913 (1), 19758187 (1), 17942784 (1) (see all 11)
    infertility 2.18 2 15992426 (2)
    lymphoma non-hodgkins 1.87 1 16056252 (1)
    sepsis 1.56 5 17615388 (3), 11740261 (2)
    necrosis 1.51 20 12441346 (3), 15735699 (1), 16428504 (1), 19809428 (1) (see all 14)
    insulin resistance 1.32 1 17563366 (1)
    influenza 1.29 3 12226087 (2), 17121807 (1)
    cancer lung 1.2 21 16283383 (7), 18520302 (4), 17079230 (1), 17876048 (1) (see all 8)
    rheumatoid arthritis 1.09 2 19035474 (1), 15754027 (1)
    osteoporosis 1.05 1 15754027 (1)
    hnscc 0.626 7 19662650 (2), 15695121 (1), 15897590 (1), 16145048 (1)
    acute leukemia 0.508 5 15514006 (1), 17395781 (1), 17671436 (1)
    immunodeficiency 0.488 1 11932435 (1)
    asthma 0.381 1 17689515 (1)
    aids 0.221 1 9738900 (1)
    stroke 0.121 1 14529386 (1)
    astrocytoma 0 1 11205288 (1)
    ataxia telangiectasia 0 1 17982489 (1)
    leukemia lymphocytic chronic 0 3 15972449 (1), 16056252 (1)
    thyroid cancer 0 5 15181088 (2), 12843186 (1), 16741950 (1)
    carcinoma squamous cell 0 7 19662650 (2), 16283383 (1), 16367912 (1), 19142186 (1) (see all 5)
    carcinoma lewis lung 0 1 10375396 (1)
    dermatomyositis 0 2 19758187 (1), 8618554 (1)
    bladder carcinoma 0 5 12942564 (3), 17525527 (1)
    polymyositis 0 2 19758187 (1), 8618554 (1)
    virus infection 0 4 12226087 (1), 15795242 (1), 17121807 (1), 18190862 (1)
    autoimmune diseases 0 3 9693973 (3)
    pancreatic carcinoma 0 3 10851351 (2), 11144526 (1)
    fibrosarcoma 0 1 15146192 (1)
    candidiasis 0 4 12821470 (1), 15040939 (1), 18299636 (1), 15963364 (1)
    heart diseases 0 1 14529386 (1)
    endometrial hyperplasia 0 5 11251965 (3), 15132902 (2)
    cervical carcinoma 0 1 11953088 (1)
    testicular cancer 0 1 14668798 (1)
    glioma 0 18 19408974 (3), 20007406 (2), 16444580 (2), 11358819 (1) (see all 10)
    glioblastoma multiforme 0 1 10746610 (1)
    pheochromocytoma 0 1 14709792 (1)
    metastatic melanoma 0 1 20032377 (1)
    autoimmunity 0 4 19558809 (1), 12753809 (1), 12791317 (1), 17357483 (1)
    atherosclerosis 0 9 19481753 (2), 17878410 (1), 20154064 (1), 11701613 (1)
    infectious disease 0 3 17645779 (1), 18246082 (1), 11051811 (1)
    stasis 0 1 17205685 (1)
    bladder cancer 0 2 17525527 (1), 17095522 (1)
    leukaemia lymphocytic 0 2 16056252 (1), 17982489 (1)
    immunopathology 0 2 8892646 (2)
    benign tumor 0 3 14709792 (1), 12970299 (1), 10891711 (1)
    malaria 0 4 14514358 (1), 17536172 (1), 7838176 (1)
    osteosarcoma 0 4 19148492 (2), 15455381 (1), 19544563 (1)
    aggressiveness 0 1 16282507 (1)
    carcinoma 0 10 12942564 (1), 8625242 (1), 9824379 (1), 9150945 (1) (see all 8)
    hepatitis b 0 6 19113837 (1), 15542664 (1), 15810071 (1), 11093792 (1) (see all 6)
    lymphoma 0 15 16056252 (4), 19966776 (2), 17610208 (1), 14624223 (1) (see all 7)
    cell damage 0 2 8892646 (1), 15358548 (1)
    periodontal diseases 0 1 12900027 (1)
    endometrial carcinoma 0 16 8625242 (5), 9824379 (4), 15132902 (3), 12476632 (2) (see all 5)
    hodgkin disease 0 17 19671844 (6), 16428504 (5), 19607667 (1)
    carcinoma renal cell 0 1 12052835 (1)
    retinoblastoma 0 2 12176997 (1), 10919672 (1)
    sarcoma 0 5 8189059 (1), 19451690 (1), 20223596 (1)
    rheumatic diseases 0 1 7921751 (1)

    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    Publications
    for HSP90AA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 9 sources (see all 1901):
    (articles sorted by number of sources associating them with HSP90AA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (1998)
    4. A proteomic investigation of ligand-dependent HSP90 c omplexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (1998)
    6. Hsp90 is regulated by a switch point in the C-termina l domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (2009)
    7. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A....Lamas S. (2005)
    8. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (2003)
    9. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)
    10. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)

    External Searches for HSP90AA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSP90AA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    Other Databases showing HSP90AA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSP90AA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSP90AA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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