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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90AA1 Gene

protein-coding   GIFtS: 69
GCID: GC14M102547

heat shock protein 90kDa alpha (cytosolic), class A member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
 Explore 139 diseases affiliated with
HSP90AA1 via
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 Human Malady Compendium 
Biological research products
for HSP90AA1    

Aliases
for HSP90AA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     HSP 862 3
HSPC11 2 3 5     HSP89A2 5
HSPCA1 2 3 5     HSPCAL42 5
HSP90A2 3 5     LAP22 5
HSP90N1 2     FLJ318841
Hsp891 2     EL522
Hsp901 2     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Epididymis Luminal Secretory Protein 522
Heat Shock 86 KDa2 3     Heat Shock 90kD Protein 1, Alpha-Like 42
Renal Carcinoma Antigen NY-REN-382 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP862 3     Heat Shock Protein HSP 90-Alpha2

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


Summaries
for HSP90AA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSP90AA1:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein
aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,
Jan 2012)

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific
target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that
is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby
causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,
ATPase cycle and chaperone function

summary for HSP90AA1:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1)


Genomic Views
for HSP90AA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSP90AA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
 102,547,075 bp from pter      End:
 102,606,086 bp from pter
Size:
 59,012 bases      Orientation:
 minus strand

Proteins
for HSP90AA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together
with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1
and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I
to stage IV
6/159 PDB 3D structures from and Proteopedia for HSP90AA1 (see all 159):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Post-translational modifications:

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P07900

    • HSP90AA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins (see all 2): HSP90AA1
    OriGene Protein Over-expression Lysate (see all 2): HSP90AA1
    OriGene Custom Protein Services for HSP90AA1 
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0042470melanosome IEA--


    HSP90AA1 for ontologies           About GeneDecksing



    HSP90AA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies (see all 5): HSP90AA1
    OriGene Custom Antibody Services for HSP90AA1 
    GenScript Custom Superior Antibodies Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for HSP90AA1

    Assay Products for HSP90AA1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSP90AA1
    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HSP90AA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSP90AA1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 ATPase-like_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein families:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone
    STUB1
    Similarity: Belongs to the heat shock protein 90 family


    Function
    for HSP90AA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific
    target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that
    is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby
    causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,
    ATPase cycle and chaperone function

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HSP90AA1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1 (see all 7)
    OriGene shRNA RFP: HSP90AA1
    OriGene siRNA: HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSP90AA1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HSP90AA1
    Search LifeMap BioReagents cell lines for HSP90AA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0005515protein binding IPI--
    GO:0005524ATP binding TAS11470816
    GO:0016887ATPase activity IDA15937123
    GO:0030235nitric-oxide synthase regulator activity IDA15937123


    HSP90AA1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

    Animal Models:
         Mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon
         5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    HSP90AA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HSP90AA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/57 super-pathways (see all 57) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)1.00
    		Development_Glucocorticoid receptor signaling0.27
    		CFTR folding and maturation (norm and CF)0.37
    		Development Glucocorticoid receptor signaling0.27
    3Metabolism of nitric oxide
    		Metabolism of nitric oxide1.00
    		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.59
    		eNOS activation and regulation1.00
    		eNOS activation0.41
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Regulation of actin dynamics for phagocytic cup formation
    		Regulation of actin dynamics for phagocytic cup formation1.00
    		Fcgamma receptor (FCGR) dependent phagocytosis0.80

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for HSP90AA1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Selected targets of GCR-alpha
    Signal transduction AKT signaling

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    5/19 BioSystems Pathways for HSP90AA1 (see all 19) 
        EBV LMP1 signaling
    NOD pathway
    TNF-alpha/NF-kB Signaling Pathway
    IL-6 Signaling Pathway
    IL-2 Signaling Pathway

    5/27        Reactome Pathways for HSP90AA1 (see all 27)
        Developmental Biology
    Metabolism
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    5/6         Kegg Pathways  (Kegg details for HSP90AA1) (see all 6):
        Protein processing in endoplasmic reticulum
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation
    Pathways in cancer


    HSP90AA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1596 Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP5CP530411, 2, 3, ENSP000000124434EBI-2211817,EBI-716663 MINT-8204116 MINT-8204092 I2D: score=12 STRING: ENSP00000012443
    RPS3AP612471, 2, 3, ENSP000003460504EBI-2211817,EBI-3440915 MINT-63931 I2D: score=5 STRING: ENSP00000346050
    MAP3K7O433182, 3, ENSP000003583354MINT-6797194 MINT-6797182 MINT-48032 MINT-6797216 MINT-6797232 MINT-49246 I2D: score=1 STRING: ENSP00000358335
    CDC37Q165432, 3, ENSP000002220054MINT-6797194 MINT-6797182 MINT-6797216 MINT-6797232 I2D: score=10 STRING: ENSP00000222005
    TAB1Q157502, 3, ENSP000002161604MINT-49177 MINT-6797194 MINT-6797216 I2D: score=2 STRING: ENSP00000216160
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006200ATP catabolic process IDA15937123
    GO:0006457protein folding ----
    GO:0006839mitochondrial transport TAS12526792


    HSP90AA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSP90AA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90AA1 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSP90AA1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CCT 018159Hsp90 inhibitor[171009-07-7]
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    Macbecin IHsp90 inhibitor[73341-72-7]
    GeduninHsp90 inhibitor; anticancer and antimalarial activity[2753-30-2]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    10/45 DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    10/113 Novoseek chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Search CenterWatch for drugs/clinical trials and news about HSP90AA1 / HS90A 

    Transcripts
    for HSP90AA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1 (see all 7)
    OriGene shRNA RFP: HSP90AA1
    OriGene siRNA: HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional cDNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 X07270.1 X15183.1 

    24/211 DOTS entries (see all 211):

    DT.100849252  DT.91781494  DT.100658316  DT.91845523  DT.100730414  DT.100730410  DT.100801571  DT.100730420 
    DT.95129185  DT.98131982  DT.100680135  DT.100730476  DT.100860129  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.120782168  DT.100846879  DT.97848044  DT.100662911  DT.95378226  DT.100730426  DT.97848122 

    2627 AceView cDNA sequences (see top 24):

    CB124900 BM761115 BX438647 CB243663 BQ651916 BQ639882 BM472848 CA417925 
    BP361918 BM827359 BQ709040 BQ028824 BQ431360 BE328211 AA381831 AA313331 
    BP371203 BQ687650 CR593964 BI856817 AA234219 AA779056 BE501582 BE783147 
    BM818131 BM798215 CR594716 AA397370 AA496907 BM771211 BG198289 BM853435 
    BX381060 BM508981 AA323898 BG286938 AI061261 CD519067 AI268569 BE896513 
    CB215018 AA552636 BX420453 BQ717200 BP357865 BM787836 BQ722786 BP350083 
    BP362207 BP354103 AA312717 BM819130 AI564565 BU676936 BI601314 AI271539 
    BQ212247 BM460053 CB152326 CB215890 BX464218 BQ670756 BQ644475 BU179452 
    BM827045 BQ640110 BM741952 BE901290 BG701657 BQ937203 BM561334 BP355451 
    BG289548 CD300351 BU956838 BQ228807 BU552755 BG104196 BE465714 BE882146 
    AI049773 BM557588 BM752011 BQ694748 BE391169 BM841644 BP343000 BE905318 
    AI298053 BF726493 AW768462 BP353471 AA307837 BU628969 BM749100 BP365858 
    AI459635 AL705044 BM770113 BF445828 AA719731 AI709156 AI640913 BP360563 
    AA634683 BE502005 BU178506 BM806422 BG191666 BM770690 BM766773 CB107094 
    BM799267 BX506426 BE796387 BQ069879 BQ672714 CD676554 CB140037 CR611827 
    BE264421 BQ049844 CA419282 BE895456 BM770727 AW078546 AI798283 CR599002 
    BQ718338 D57328 BQ424787 CR610614 AA340224 BQ774741 BF724655 AI984720 
    CB158144 CD106194 BI088872 CB126230 AI312946 AA653472 BM505616 AI922511 
    CB269249 BM784370 AA599081 AI251771 AA335286 BM825854 AA586565 BU620802 
    CD243586 BP365680 BP355481 BQ877032 AA911271 BM834007 BU192039 BG335218 
    CB124639 BU166257 BG714640 BG682208 BQ787082 AL041434 BG706742 BE792378 
    BX425177 BM746188 BE301021 BP365739 CB122614 CB129018 BP364747 BM794341 
    BQ648886 AV725137 AI718522 AA577378 BP362990 BM771415 CB142582 CB126215 
    BM459163 BM799197 AI434367 BP349485 CB136299 BX439268 BM773296 BQ276391 
    CB124358 BQ879835 BE790272 BU521144 BP340180 BP341237 AU122899 CD171888 
    BM771258 CB216345 CB126787 BM754651 BM741217 AA381247 AA846481 BP349381 
    BP363338 BM787588 BQ215919 BM771150 CR605488 BQ650387 AA371096 BM548872 
    BM748494 BP353188 BU196611 BM998981 BM847345 BX404036 AA629744 AI889101 
    BP364217 BG188540 AI630318 CB134095 BG209237 CB132703 BQ688439 BP356728 
    R17724 BG114540 BQ685380 CB132687 BP366989 BM050381 BP354510 CB147677 
    BP357174 BQ446823 BM456889 BQ650483 CB122939 BM661484 BQ932268 BF173150 
    CB147496 N72134 BQ648064 AI355163 BU526778 BU167848 BP429471 CR604052 
    BI861290 BM770204 BQ058567 BG675969 BP343914 BE888198 BE772654 BX449722 
    BM771876 BM851100 AU122898 BE795839 BE889713 BP365758 AW117847 BE796186 
    BE793051 BU169696 BM771152 AV708446 BM915436 BM787498 CB116075 BI253585 
    BX437631 BM697262 BM556606 BP363032 BP375623 BF793825 AL043533 BU175493 
    AA583125 BM770089 BX248761 BM792103 CB999080 AA301285 AA605055 AI143846 
    BP357786 BM833702 AI355450 BE882812 BQ686070 BM907693 BP354342 CB132694 
    BP354234 CR589993 CB143168 CD369784 BM475970 AA381317 AI082335 BP356131 
    BU687394 AL045528 BP346832 BQ650162 AA300666 BQ723338 AI587534 BM835505 
    AW589959 CR621835 CB112685 BQ653287 T16337 AA319049 CB120885 BQ647746 
    BM787542 BG575115 CR613014 AA362041 BX458987 C05220 BP378007 BP365313 
    AA806023 AW732111 CA422318 CB112476 CA395677 BM834011 AL044323 BP341074 
    AI201555 BM766516 CD243399 CD367392 BE273428 AW839201 BM822173 BU195258 
    BE673447 BU145598 BP350134 BP341978 AA991757 AA070581 CB133876 BQ918848 
    BX429662 BE385413 BU535587 BM756802 BX442082 BM839745 AA405380 BQ652761 
    AA026247 BP348522 BM479754 BM844073 BF794523 BM770103 BE744769 BG397158 
    AA829914 BQ056381 BU686197 BQ720223 BU957557 BU509076 BI855905 BE274256 
    AA369744 BQ230238 BP365769 AA937732 BM463891 BQ070476 BE793879 AW613680 
    AI015385 BP354798 CB134556 BX449873 BP356997 BM801932 BX439584 BM762552 
    BC000987 CB113042 AA593911 BE887678 BP356104 Z19686 BU153102 BQ882638 
    BM799387 BQ438187 BP358984 T16196 CR611873 BX410474 AI167737 BQ351606 
    BQ431434 BM771547 BM770968 BM564809 BX462964 BQ424759 CB106878 CB120517 
    BQ423532 BM755572 AA808379 AV728233 BQ643276 BM745779 CA431938 BQ637733 
    BU543215 AA478385 CB125658 BM771351 BG391002 CD366438 BP348618 BE348238 
    AL043938 AI056091 BM475205 BQ437226 AA984403 BQ421675 AA301216 CB133855 
    AA320280 W02709 AA364478 AI798322 BP353141 AW341770 BX423174 BP365062 
    CN482865 BE898989 BP356322 AA059021 BM772069 AI341414 CR623660 BP353451 
    BP352108 CB121606 F08468 BC001695 BX450093 BP359526 CB143277 AI376570 
    BM787584 CB134795 BG395330 BP351634 BG822924 BC023006 AA988694 BE300873 
    BP365517 BM905289 BQ432259 BQ775553 AW151383 BF204760 BM740919 BM771405 
    BM741834 BP349705 BM789803 BQ689339 BP360061 BX408694 BP354457 CB154325 
    BP372585 AA076019 BM833745 BM468465 AA312098 BM722754 BP363669 BP353302 
    AI288092 BE935721 BM835503 BP354211 BQ936560 BQ926539 AI042136 CB134656 
    CB138182 BI460668 BX429503 CD557163 BI492909 BU169711 BM832717 BP363421 
    BM760149 BG482623 AU126747 AI707926 BQ434401 BM771320 BQ670638 AA370644 
    CB134176 BM771163 CB126322 CB123140 CB136302 BM827330 AA318966 AA740971 
    CB131957 BE901945 AA300826 BQ637596 BG575099 AA617738 BE747401 BM787784 
    BU169854 BU151252 BP349697 BU857171 BP357636 BX444743 AA457613 BM745750 
    AA865484 CF147283 BG722028 CR596117 BQ679110 AA984886 BX247955 BF983468 
    BG216655 AA748157 BX345539 AU076823 BQ716766 BQ646790 AA968767 F08576 
    BG339154 AI650434 BP360612 CA946401 AV709818 AW498638 BU631732 BX450559 
    BM557327 BX462517 BM771816 CB158361 BM801990 CB123508 BQ233026 AI878849 
    AA375568 CR607053 BQ651961 BP356585 BM453507 BQ773951 BE879319 BQ686689 
    BG741137 BG777524 BP363688 BM771947 BQ646998 BE151642 BP363467 BQ278816 
    AU123455 CA389410 BP363527 AW273526 CB145935 BE884453 BM562561 CB129659 
    BE017983 BU929327 CN483876 BE383723 H85344 CD300585 AI444927 CB112532 
    AA488124 BE747071 BU185701 BP342547 BE834094 BQ720448 AA381950 BU158844 
    BF725727 CB132798 CB111454 BX447525 BF984401 BX443750 AI335809 BM553281 
    BI670275 BP350022 BP334337 BU956268 BU191161 BX461517 CB125430 BX418326 
    CR619460 BP364931 BU688393 BG110413 BM974105 CB125295 BP368514 BP355457 
    BP366065 BP338915 BE549867 BG169410 CA419919 BE090288 BP354180 AA773988 
    AA249241 BP356116 BG105073 BX421404 AA309988 AA374728 BG202376 BQ648560 
    BP363023 AI611715 BG221143 BM763379 BM834626 BG393826 AA071048 BU181630 
    BQ644545 BM746030 CB124367 AI299100 AA629775 AI580019 AA629563 BE787782 
    BP337047 BM193359 BQ651520 CB134610 BU735941 BF982793 AA629423 BM827085 
    BQ651041 BI559745 BU581404 CF541408 BQ883302 BP373289 BX646208 BQ050923 
    CR615580 BM740970 AJ715028 BP364960 CD513222 BQ689317 BG292008 AA653657 
    AA662904 BM771890 BP348501 BP365038 BP348155 CB132719 AA314010 AA314167 
    BP354356 CB136175 BP363052 BM802957 BM827355 BP351143 BM838322 BM771898 
    CB125743 CB132574 BM763718 AW498642 N56874 AW302254 CA422056 BE797314 
    BM697255 BI870587 BG761824 BQ278939 BI464355 AA773063 BP359335 BM827807 
    BP355452 AA513695 BU688452 BM888106 CB147640 BM553831 BM770697 CD677111 
    AA903458 CD675581 BM842712 CA308472 AA013209 BE302141 BX429763 BP357063 
    BM833582 CA393189 AI801059 BP365810 BU431687 CD370291 BP357254 BQ648360 
    BQ066643 BE744069 AI583541 BQ225225 BP349366 AI401488 BE263688 AA640476 
    BQ923652 AA457519 BM981119 AI683529 BM788422 R29466 AA353916 CB161318 
    BE252341 BM852892 BE018557 BP349341 BQ653704 AA666356 BQ637106 AI468222 
    CB126733 BM978802 BQ277871 AW470589 BQ064596 CB148778 CB134959 BQ946011 
    AA777985 BM844731 BI462032 CA748788 BM801487 BM802308 BP359238 CB134106 
    BM751979 BP364063 AI915706 BF448028 BQ215456 CB122471 AA586919 AA570011 
    BM770087 BP341404 CB134180 BQ890155 BG474613 AI473900 BQ931644 AL709992 
    BQ638075 BQ427532 BM474358 BM978852 CD358934 BQ083109 BM710634 AI334832 
    AA357095 BE889253 BM823282 BQ056810 BM770054 BE732032 BQ648656 AV660283 
    BM771323 BX432784 BI669430 BP360734 BM794320 BM771472 BM770164 BU735935 
    AU123681 AW572506 BP364892 BM564793 BM834502 BI547743 AW085674 BM835674 
    BX421248 BM770685 BQ232742 BQ310971 CA420189 AI571459 AW769841 CD642974 
    BG740397 AI952706 BX429886 BP363719 BP357436 BM014443 BG285004 BI117307 
    BP353773 BE892001 CF541173 BG547406 BM838778 CB134187 AI623359 BQ427554 
    CD640012 BU857701 AI680181 CB132707 AA626744 BP355647 BG421056 CA315060 
    BP348963 BE874493 BM542657 AI003357 BG723122 BM741434 BP355864 CB147635 
    BG324799 BM832992 AA310601 BU626011 BG418985 AV756334 BF026023 BU177028 
    BQ231785 AA315439 BF308231 BM469186 BM789447 AI816457 BQ694825 BP353109 
    BM762068 AA339411 BP363744 BQ437648 BQ681826 BF337005 BX326017 BM749614 
    BM829499 BI089071 AA133890 BE741417 BP353402 BQ685091 BU171768 BQ694564 
    AV714108 AA356840 BG677196 BE893889 BP363216 BU192493 BQ775638 BM770979 
    BG112522 BQ064487 BG434834 BM834412 BP359120 BM834150 BM464756 BX462356 
    BX411092 BF032941 BM770755 BE799905 CB961329 BP363936 BG942842 BM787678 
    BI115963 BM006074 BM976869 BU538137 BI117290 BF034530 BQ677380 AI859951 
    BX449814 BG024230 AA564649 BX407458 BQ691908 BG163650 BP363248 AI090489 
    CA445435 CD300374 AW071112 BF979822 BQ351893 BQ340541 AA235842 BM835423 
    BQ878293 BP380713 BP347736 CB998913 BU542097 AA548565 BG171332 BG751168 
    AA644346 T49737 BU942308 AA314095 BP345107 BG248669 BP354441 BG759642 
    BX429400 BP366094 AU126227 BP365671 BM955671 BQ351756 BQ348771 BP358742 
    BG283102 BQ688036 BP371075 BX408743 BX408809 BE789184 AI474479 CB134344 
    BI858531 BE388737 BG257351 T08937 BM835566 AA134010 CA446614 AA093560 
    BP355186 BM788626 BP335136 BP355908 BM852436 BG104287 AA353064 BG397826 
    BG281933 AW498915 BP359166 AA339747 BP356764 AW162634 AI630175 BX458092 
    BE882463 BX414082 BE301149 BU950192 BU942049 CK001974 BX408544 BI860505 
    BP372812 BQ719635 BP350794 BM758521 BM751251 AI422887 BQ440818 BQ691587 
    BG284104 BM792191 BU179681 BQ429507 CB152057 BP356709 CA419296 BG338310 
    BU146752 BE885743 BG570579 BM781865 BG336997 CB134332 BE276535 BQ880307 
    BQ433859 BF128634 BE276298 CB163921 CB134356 BE901228 H99923 BU195296 
    BG772363 BX429146 CA417640 CD103125 BQ959832 BX429893 BQ217159 BI458380 
    BM784893 BE782936 BM835662 BP365520 BM904495 BM750748 AA306826 BM792563 
    BP361839 BM468469 BU945555 BP355540 BG340227 AA356714 AW469463 CB106340 
    CB135693 BU160494 BU630061 BP355760 AA497069 CB119871 BI461007 CF993948 
    BQ940560 BQ311720 BF972338 BQ680893 BI117010 AW513639 BP354125 BU858503 
    BX407806 BG708051 BM472864 BF026846 BQ958515 BF979284 N34251 BE264030 
    BG283935 BM009954 AW149906 BI464443 AI266215 AI979099 BG289859 AW149862 
    CB853790 BX428767 BX408485 CB140669 BX450764 BM749102 BI117018 BM794250 
    BG480206 CB131968 BI597751 BG427434 BU538672 CB148113 AL045961 BG541817 
    BM014625 BM504491 CA417837 CA395866 BE892885 AW675456 BI551485 BG701752 
    BQ718134 BF025820 BX439717 BG292357 BE268081 AW571560 BG282141 BG388282 
    BM835671 CB136142 AW902632 AA364389 BQ231715 BP354074 BU845052 BF975201 
    BU729713 BU676981 BP357373 BG291970 BQ440415 BQ071906 BG723783 BM796404 
    BP375297 CB112801 AI094164 CF146559 BU682388 BU629329 AV725438 BX400070 
    BE876023 BE538745 BQ230557 BF036642 BQ222889 BP357051 BI548244 BU689173 
    BG714859 BM005757 BG756323 AI803387 AA630652 BM090654 BP353400 BG479257 
    BP349807 BG185911 BP355935 BP380620 BM549980 BM834226 AA191282 BP341192 
    AU123157 BE272063 AA360913 BX450544 BG574789 BX452882 BX450399 BF038655 
    AA482327 BM999305 BU932356 BM771234 AW245186 BP354624 BQ775921 AI539592 
    BM832464 BM827964 BP364718 BQ351616 BQ360396 BP364697 BX494275 AJ714902 
    AA223171 BG547132 BP356890 BP354860 AA216434 BE294066 BE276457 BG612887 
    BP349361 BM787583 CA420816 BU194091 BF438506 BE903080 AI207707 BP361930 
    BQ722147 CA418368 BE741698 AA307057 BF684109 AW161068 BQ953366 BQ056805 
    BP353937 BQ774768 CB139283 BX408742 AA132815 BU685827 BP363589 AA706279 
    BG774144 BP356124 CK002723 BE266356 AA857523 AA120908 BG397902 BE780815 
    AI089281 BP360900 AI983238 BI597025 BQ638414 BG290828 BX449730 BP354730 
    BE888254 BF026049 BE878706 BP360936 BG289676 BU166480 CD356450 BM836527 
    BM845769 N41314 BG207603 BQ351736 BU174037 BF037183 BP358050 CB134090 
    BG614604 BE536707 BG745446 CB124187 BM556629 BG827229 BE891315 CD244499 
    CB164057 BU189219 BE894631 CF594107 BU157539 CF780809 BE253510 AA307671 
    BU687472 BF038555 BE613850 BM742799 AI092228 BG473460 BP354204 BP359543 
    BE780700 AI687004 BX451852 BM909923 BM542703 BM558376 BX450050 BU167259 
    BM789129 BF973255 AL710682 BX347362 AL047200 BG420237 BG289647 AI902943 
    AV756792 BP370170 BP372802 BQ436727 BP358805 BG545698 AI685234 AK056446 
    BE735758 BI850721 AA370165 AA381564 BM743378 BE267266 AA708235 BP347238 
    BP365335 BG491269 BE265118 BM787553 BM835710 BG027434 BQ717290 CD300733 
    BU630012 BU543868 BP365449 AI890897 BQ646505 BM017471 CB409432 AA357253 
    BE207495 BP380622 BU933219 CN485036 BI088544 BM751997 BM799253 AA214083 
    BM479916 BU539215 AW615324 BX422652 BX410473 BP339139 CK024012 BG287252 
    BE278498 BU169266 BX446993 BQ360171 BI597709 CK024097 CK003809 BE898524 
    BU194668 F36751 BG215547 BQ438205 BP349081 BE298818 CA440454 BG104205 
    BE549418 F04690 BQ938167 BX434332 AA371459 CB112960 BM828361 CD300070 
    AW249642 BF314704 BM751858 AI468968 BP377964 BM759527 BU678266 BG699496 
    BG419926 BM770680 BM460711 CA443465 BQ351610 BF205554 BP341144 BG478839 
    BP364405 BE541056 BG205395 AV688833 BP354772 AW084778 BE877044 AA331252 
    BP337342 BM787879 AV707039 BX450714 BQ877018 CD243970 AA774999 BQ020503 
    AW081635 BM827984 BG532378 AA991208 BU521703 BP355554 BX443003 BM793683 
    BX500541 W76644 BF980555 AW572409 BM450631 BP349769 BG686714 BU171689 
    BG424330 D56121 BU556882 BQ685997 AI065000 BU182116 AI808104 BU508375 
    BQ351725 CB114672 CD110324 BX407811 BG748114 BM853647 BG477845 AW769840 
    BG497557 BF686286 BE744566 BM090605 BI869557 BX487201 CA446986 BU615165 
    BX495613 BI551942 BQ689485 BG675007 BM016093 BM045296 BU154145 BX478917 
    BM984767 BQ227711 BX495971 BU944640 CB134593 BX407775 BP361190 BU600536 
    BQ653966 BI562093 AA356627 CD109731 BM047388 BQ646742 BM835843 BX462405 
    AI174952 BP359706 BG681060 CD359890 BM009912 BP355677 CB409511 CF126651 
    BE734269 BF128762 BX416309 BE315127 BX450651 BM836062 BP354149 BX408889 
    BQ947778 BP364607 AA419412 BX429293 BQ639161 BP355317 BP372818 BM046393 
    BP363383 BQ776250 BP358136 BP365267 BM839633 AI880522 BP382651 AW902549 
    BF174989 BP337701 BI596554 AA353752 BM470403 BP337493 BE886493 CD643121 
    BM460113 BU177948 BX450534 AA985095 BP363937 BG286966 AA502598 BQ217096 
    BU508282 BP357862 CF139933 BE707294 F27287 BG336589 BU195567 BU193760 
    BP350266 BG284836 AA129370 BE386278 BP363254 BM564713 BG200735 CA406303 
    BG574690 CD642508 AV649676 BU176685 BM827660 BU595042 BP365712 BP361295 
    BC017233 BU179638 BM835441 BM843569 BU194003 BQ438105 BQ351751 BX429016 
    AI744717 BG196262 BP355969 BP364605 BP365535 BQ213099 BM465777 CB135370 
    BP374826 BU933081 BP364859 AI735365 BM834939 AI090696 F27516 BG035664 
    AA587981 BP364078 BE622572 BP355107 CA417103 BG200356 CD557018 BQ351666 
    BG776818 BG756223 BP353116 CB115080 BM449943 T27391 BQ775989 BX416351 
    BI560266 BU185532 BP343950 AA679253 BG326918 AI969532 BM817677 BF025892 
    CD251848 W73056 AU123790 BM475063 BE264128 BU164481 BP340789 BX404657 
    BU553466 BF685851 BP366046 BG034614 BG117726 BP363934 BP364338 BX423094 
    BU781967 BE268044 AJ714083 BF698935 BI258801 BP356345 AA703772 BQ351705 
    BQ926636 BP361901 BF686544 BQ894635 CD244989 BE266239 BP353723 BG204984 
    BM835757 BP361425 BG031692 BE795929 CB988109 BQ719459 BG717081 BE901924 
    BG421722 BI562341 BE501669 BP365312 BP349364 BP355744 BE302151 BM006618 
    BG720871 AW518825 CD513906 CB961585 BE048702 AL038129 BE742826 BP357405 
    BI462467 BG708576 BM014389 BU674727 BX496316 BF309384 BE743661 BQ642828 
    BX429329 BM745318 BQ221228 BI596578 BF576079 BP346936 BI870095 BU171509 
    BP354532 BE889051 F03806 BE797111 BP361312 CB135332 AW780228 BP346192 
    BX387984 BQ268388 BI465070 BQ775147 BF688223 BP349252 BG615754 BE386388 
    BP355310 BG326343 CA418209 BP345814 BX450351 BX429367 BG696742 BE744862 
    BE384187 BE790647 AA704189 BP366283 AA699607 BM771143 BE730766 BG620390 
    AI394675 BM829208 AI719356 BG189060 BE741489 CB135862 BG424774 BP364069 
    AA578660 BG681395 BF025862 CB118720 BU687745 CA441408 BQ351607 BG772226 
    BG194253 BP349633 BP360473 BX408321 BE716035 BG753150 BE385779 BM754083 
    BX429748 BX406667 BM796525 BI553926 AA333236 BP364350 BE777964 AI922501 
    BX450684 BE792969 BI600423 AA374231 BG574952 BG395366 BQ045432 CA415013 
    BM827838 BE382772 BP349332 AV652506 BQ008757 BG291324 BP349360 BM828617 
    BP352144 BF686109 BG290965 BQ691270 BG429782 BQ351934 BE269673 BM781449 
    BX440283 AA320835 BG341494 BP371119 BX408660 AA300804 BG615180 BQ439853 
    BG754077 BG772644 AW157708 AA565553 BQ350320 CB120653 BM459146 BP351305 
    BM827598 BE268085 BP364434 BP355462 BP356519 BP366309 BG761047 BE266762 
    AA316195 AI580322 BQ636100 BX506465 AF074699 BP363586 AA984694 AA365619 
    BU189393 BG184335 BX413706 BP364565 AA629891 AI375668 BQ426004 BE744275 
    BP372190 AL705103 BX438704 BM974607 CB128594 F29908 BU686526 BF204764 
    BE897273 BP364725 BG290197 BE882990 BP356437 AI081361 AA683206 BC007989 
    BG214461 AL046504 BE780007 BP345936 BG620186 BQ690319 X07270 CB132365 
    BG291922 BX408017 BP357213 BU674816 BP346189 BU597108 BF674008 BP369342 
    BP377994 BM511980 AA380967 BQ676204 AJ713393 BM821862 BG184330 BM740981 
    BP354974 BE278240 BX408659 BF686119 BM745738 BG913640 CB158569 CB144577 
    BG530606 BQ935401 AI377472 BI600054 BG291915 BQ638645 AI352264 BP353455 
    BQ432799 BM787270 BP366204 BP348949 BG528922 BI559881 BU542725 AA026444 
    BP349380 BE887720 BG740127 BG195778 BX438139 CD102650 BM046384 BI159911 
    BU542070 BU158444 BM790221 AA666061 BP365055 AU129848 BP365071 BI547467 
    BG756408 BG705954 BE742334 AA320116 BM833537 AW672867 CA417821 BE787174 
    BE895803 BI088137 BF037018 BP349643 AI859281 AA991804 CD356101 BE892481 
    BX429937 BG761594 AW503031 CF455720 BM754653 BP358744 CA417967 BX952212 
    AA370504 AA383454 BP351167 AA086423 BP365906 BU190844 BG428808 BP365872 
    BG547687 BX445552 BP379057 BE893586 AI818880 BX419794 BX641634 AA563811 
    AI816296 BP347975 AA305037 AI016543 AA357454 BX646864 BG029407 BG389458 
    BF343519 BM755541 AU122886 BM741947 BG255545 BE395967 BM834363 BE275314 
    BM558627 BI224350 AA599238 AI926828 BX450262 BM835712 AI005344 BQ441067 
    AW168775 BI599852 BU732620 AA303631 BM471509 BQ645817 BU167557 CF126448 
    AW264114 CB156030 BG771608 BM470436 BU958911 CA422230 AA310695 BP354681 
    CB152257 BP355454 BE899252 CK003121 BM822192 BE621978 BE540478 BM745761 
    BF208054 AA370456 BG180963 BG403752 BU509561 CA448560 BX387983 AA306270 
    BP354481 BG261316 BQ343701 AA725103 AA351203 BU163401 BP365857 BP354778 
    BX449987 BP337734 BP355246 CD105178 BQ951837 AI742363 AA371200 BX408175 
    AA099074 BQ231349 BM976663 BG480678 BE727316 BG024612 BP360469 BX428746 
    BM457327 AA666249 BP383463 BM828369 CD102005 BG030941 BF974362 BM755216 
    BX429017 AJ713652 AA602299 CF140337 AW161279 BQ278328 F28496 AI401635 
    BP362353 AI201790 BE799410 BE881191 BX450190 BP346903 BP357675 BG699612 
    BG284408 AA375987 F36820 BE895466 BE256139 BM798416 CD364858 BE393310 
    BF751036 CB136178 BX450175 BG191034 BU155756 BU162735 BP350963 BM090832 
    BP357449 BQ918361 BG718990 AA985112 BG170970 BM745597 CK004221 AI089273 
    AA372480 BP356752 BM833040 AA334804 BG255991 BU145858 AW673676 BP364194 
    BP356175 BE542334 BE874820 AA306976 BU165439 BG565941 BQ679117 BQ278199 
    AI630519 BE221359 AA323607 BQ005716 CB961584 BX953123 CB961248 BG167405 
    BQ639029 BQ689868 BQ230351 BE784768 BI869349 BI857054 BQ222901 BM787451 
    BX425456 BM771431 BE890715 BE780376 BX449761 AA312400 BE888053 BE887364 
    AA192385 F04787 BG260362 AW571632 BG180775 AA320302 CA412078 BP336361 
    CA418071 BI860660 BE897016 BM794262 AA383729 BE408286 AA229107 BP356281 
    AA312386 BP349602 CB134075 BE536491 CB143989 AA316587 BP366984 BP368276 
    CA439337 BQ323764 BU681406 AI272184 BP354278 BP362570 BF221833 BQ682726 
    F09961 BP364996 AA668543 CD512397 BG325276 BP355336 BM845485 BI546603 
    BI561300 BP344055 BF797661 AA356486 BP363394 AL038130 BM833525 BM046400 
    BP381953 BU951773 BG566910 BQ006474 BP355010 BQ048993 BQ276361 CB143565 
    BX367632 AW023404 BP357711 BP348084 AI096990 BX478367 BG186462 BE879242 
    BX325777 CB132857 BX328801 BM793259 BG502440 BQ684434 BM504273 AI925796 
    CF144702 BP348628 BP365377 CA418135 BM745923 BP363598 BE793288 W56527 
    BG255340 BQ314685 BP364843 BX460056 BI603518 CB998808 BQ879999 BE743429 
    AW272310 BG472704 BE410080 BX485754 CB124533 BG403704 CA395053 BE535845 
    BQ876420 BU860914 BQ946092 BQ896636 BE677551 BQ424753 BP365326 BM842950 
    AI814212 BG339431 AV705885 BX424913 BI816693 BP364692 AA130815 AA171758 
    AA132704 BM750040 BE901519 BM771162 AA206075 BU155644 BG719543 BQ317558 
    AI347442 CB123974 BX403839 CF995684 AI371186 F12340 BM787749 AW514752 
    BE744444 AA921967 AA120909 AA644668 AW339156 CB122800 CB123132 BG334594 
    BM751868 BP356255 AL121253 BE889602 BE075923 BE728427 AA214035 CD105385 
    H84679 BF026863 AA773161 BX408060 AA308606 AA171998 BM471694 H94609 
    AI184461 BP364267 AA319883 BM680263 AA827522 BF035067 CB152885 BM765395 
    BE709875 BP364521 BP381918 AI799397 CB114441 BQ775119 AW150199 BQ706145 
    AA371492 BP355353 BM462658 BM770961 BG025312 BM679591 BE744684 CB136126 
    AA778423 CB114936 BI117278 BM453635 NM_005348 BQ057059 AA365777 AA703828 
    BF034628 BM787724 BM976034 AW291073 BQ921749 BQ775724 BU631792 BP352291 
    BU158742 BE901220 BX429873 AI003330 BU856916 BE780823 BE561569 BM452892 
    AA626817 BG616242 BX434560 AW057643 BG339697 CF128086 BG325387 AA351665 
    AW403943 BM462689 BP342280 BE744252 AI924799 BP360072 BE292794 BM721168 
    BP355412 X15183 F22795 CF785936 BM745590 BF026296 BG393123 R52323 
    BP364310 BQ774002 CB305999 BX429290 BP354339 CB851315 BM837058 BU172200 
    CF122122 BM973982 BM704177 BP353246 BE272291 CK000235 BP353968 BM749151 
    BE891640 BP375817 AU279662 BM833880 BQ214952 BP355575 BE391279 BF448035 
    BG944658 BG424451 CB148676 BM745285 BE280814 BP355906 BP350738 CB962103 
    BP362618 BM353224 AA669137 CD106877 BF973561 CD557527 BQ351716 CA423232 
    BU950480 BG198125 BM310052 BM833047 AV728908 BE889647 AK129557 BM090880 
    N47762 BG778350 AI110792 BP365230 BM552623 BP363718 CA424392 BI089367 
    BU674027 BX408557 BM811462 BG104825 AA630369 BP359102 BM015978 BP361334 
    BG472184 AI000357 AW902548 AA076020 BG677512 BU933549 BE315545 AA679491 
    BE177723 BQ683437 R29731 BI600585 BE794630 BG200354 AI311913 BM829007 
    BG179584 BG569320 BM787476 AI962866 BE786120 BM839422 BX340856 BM759085 
    BQ348772 BM751888 BX408795 N50947 BF972290 BP359443 BE793037 AA568731 
    CB988207 BP364379 BP356847 BM835155 AA552549 CB160280 BM755674 BM835481 
    BX438531 BG530549 BG220675 AI886733 BP360795 AA361608 AA383060 BM006640 
    BI857860 BP383256 BU188596 BU838705 BG338786 AA513807 BP355109 BG875921 
    BF103833 BU160618 CB133779 BM750399 BP375807 BM353379 BP363463 AJ707187 
    BQ943392 BP363377 BM794800 BQ026788 BG828134 BP364031 BU958743 BU594684 
    BX429865 BM835656 BX411091 BU507450 BM796037 BQ049305 BG392631 BF038736 
    BP349428 BE384808 CD522337 BM819186 BP347759 BP354689 BM832731 BQ071421 
    CF139473 BQ924340 T08862 BP363788 BX470282 BM852900 BE740859 BX408167 
    CD105800 BM835449 BP363565 BE894580 AA402284 AI380044 BM982326 BU789208 
    BE785041 BP339770 BQ775547 BU623165 BX408319 BE741577 AI954116 AI338430 
    AA357506 AI032857 BM750463 BM832526 BU943935 BM789194 BM833513 BQ772555 
    AA708498 BI093337 BP348787 BG193239 AA306893 BP339584 AI581146 AA301229 
    BU508632 BG178464 BX421977 CB216341 BQ005714 BQ897317 BX459988 BI546871 
    AL044324 BM827702 BM041939 BM833049 BP350509 BE272716 BQ688846 BI438939 
    BM835692 BU782867 BX420477 BP360074 BP352753 BQ420439 CB989811 BG288987 
    BI460801 CA417560 BM794909 CB409232 BU521376 BQ694576 BQ319043 AI174842 
    BF983066 BP354469 BX406883 BF975974 BE795628 BM751684 BF315264 BQ223489 
    BM817439 BQ351892 BQ232433 W56591 BI464350 BP363204 BG180070 CA440452 
    BG254833 BG699179 BP364693 BP363387 AA364614 BE868465 BF036446 AI954471 
    CD512377 BU941176 BE501656 BP347407 CN479227 BE614457 BE887391 AA223172 
    AA013363 BX450468 BE299233 AA356106 AA099565 BX455227 BU147213 BM424217 
    BX429074 CD642932 BQ378484 BM146435 BG037050 H85198 AA244154 BF688608 
    BE787672 BG528988 BI551637 CF139787 AW388972 BM689490 BU165201 AA112734 
    BX450871 AA192634 BG187992 BE302661 W00382 R54487 BG197250 BG185910 
    BG200355 BM042528 BX408222 AW663290 BX347352 BF129778 BE967085 AA214188 
    AA206255 BE966696 AI879407 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    Expression
    for HSP90AA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTAGTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HSP90AA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    LiverLiver LobuleLiver
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)

    See HSP90AA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSP90AA1

    SOURCE GeneReport for Unigene cluster: Hs.525600
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    Orthologs
    for HSP90AA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HSP90AA1 gene from 10/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.3(n)1
    99.18(a)1    		   12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)    		 Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.37(n)
    96.43(a)    		   423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HSP90AA16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 GL343232.1(1912641-1917038)
    zebrafish
    (Danio rerio)    		 Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hsp836
    		 Heat shock protein 83
    		 79(a)
    		 possible ortholog
    		 3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)    		 Secernentea daf-216
    		 Heat shock protein 90
    		 77(a)
    		 possible ortholog
    		 V(14684903-14688528)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes HSC82(YMR186W)4
    HSP821    		 Cytoplasmic chaperone of the Hsp90 family, redundant more4
    Hsp82p1    		 62.96(n)1
    64.05(a)1    		   13(632355-634472)4
    8558361  NP_015084.11  8552244 
     NP_013911.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HSP90.11 heat shock protein 81-1 66.81(n)
    73.81(a)    		   835341  NM_124642.3  NP_200076.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 heat shock protein, putative, expressed
    (see all 9)    		 72(a)
    71(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 9(18513571-18517315)
    8(24716372-24720839)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria htpG6
    		 protein refolding molecular co-chaperone Hsp90, Hs...
    		 39(a)
    		 possible ortholog
    		 Chromosome(494344-496218)


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available) 

    Paralogs
    for HSP90AA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90AA1 gene
    HSP90B12  HSP90AB12  TRAP12  
    13 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    HSP90AB1    HSP90AA2    HSP90Be    HSP90B1    HSP90AB3P
    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1    HSP90Bf
    HSP90AB2P

    HSP90AA1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    Genomic Variants
    for HSP90AA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1163 NCBI SNPs in HSP90AA1 are shown (see all 1163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs22774661,2
    		C,F,H,--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    		C,F,H,--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    		C,F,H,--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    		C,F,H,--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    		--102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    		--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    		--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    		--102547092(+) ATTAAC/GTGACT 2 -- ut310--------
    rs10596291,2
    		C,F,H,--102547105(-) CTGTGC/TTAAAT 2 -- ut3123Minor allele frequency- T:0.10NA NS EA WA CSA 1791
    rs1506053111,2
    		--102547184(+) GGGATC/GCATGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HSP90AA1
         3 CNVs: 76736 66711 87364
         1 Indel: 87365
    Human Gene Mutation Database (HGMD): HSP90AA1

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    Disorders / Diseases
    for HSP90AA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSP90AA1 for disorders           About GeneDecksing

    OMIM gene information: 140571    OMIM disorders: --

    20/139 diseases for HSP90AA1 (see all 139):    About MalaCards
    hand-foot-genital syndrome    dopa-responsive dystonia    atypical teratoid rhabdoid tumor    renal carcinoma
    carcinoma    anaplastic large cell lymphoma    peutz-jeghers syndrome    neuronal intranuclear inclusion disease
    gastrointestinal stromal tumor    lichen planus    long qt syndrome    oral lichen planus
    waldenstrom macroglobulinemia    malignant pleural mesothelioma    non-hodgkin lymphoma    lobular neoplasia
    ataxia telangiectasia    rhabdoid tumors    amyotrophic lateral sclerosis    myasthenia gravis

    3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    10/91 Novoseek disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    Publications
    for HSP90AA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 9 sources (see all 1901):
    (articles sorted by number of sources associating them with HSP90AA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (1998)
    4. A proteomic investigation of ligand-dependent HSP90 c omplexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (1998)
    6. Hsp90 is regulated by a switch point in the C-termina l domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (2009)
    7. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A....Lamas S. (2005)
    8. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (2003)
    9. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)
    10. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)

    External Searches for HSP90AA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSP90AA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    Other Databases showing HSP90AA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSP90AA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSP90AA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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