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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSP90AA1 Gene

protein-coding   GIFtS: 69
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene: 
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and lobular neoplasia, and among its related super-pathways are NOD-like receptor signaling pathway and G2/M Transition. GO annotations related to this gene include protein homodimerization activity and identical protein binding. An important paralog of this gene is HSP90B1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSP90AA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
102,547,075 bp from pter      End:
102,606,086 bp from pter
Size:
59,012 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction,
together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex.
Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination
systems
Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
stage I to stage IV
6/162 PDB 3D structures from and Proteopedia for HSP90AA1 (see all 162):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • UniProtKB: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07900

  • HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSP90AA1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900
    Human Recombinant Protein Products for HSP90AA1: 
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    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins for HSP90AA1
    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1 
    OriGene Custom Protein Services for HSP90AA1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    HSP90AA1 for ontologies           About GeneDecksing



    HSP90AA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies for HSP90AA1
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    GenScript Custom Superior Antibodies Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1
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    ThermoFisher Antibody for HSP90AA1
    LSBio Antibodies in human, mouse, rat for HSP90AA1 

    Assay Products for HSP90AA1: 
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    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family


    HSP90AA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): 5/18 molecular function terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding IEA--
    GO:0002135CTP binding IEA--
    GO:0003729mRNA binding IEA--
    GO:0005515protein binding IPI12526792
         
    HSP90AA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    HSP90AA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSP90AA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSP90AA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSP90AA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSP90AA1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSP90AA1
    Sirion Biotech Customized adenovirus for overexpression of HSP90AA1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSP90AA1 (see all 14)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    Sirion Biotech Customized lentivirus for stable overexpression of HSP90AA1 
                         Customized lentivirus expression plasmids for stable overexpression of HSP90AA1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HSP90AA1
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSP90AA1 About   (see all 61)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    3Metabolism of nitric oxide
    Metabolism of nitric oxide0.59
    eNOS activation and regulation0.59
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.59
    eNOS activation0.41
    4Signaling by FGFR
    Signaling by ERBB20.90
    Signaling by EGFR in Cancer0.83
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for HSP90AA1
        Immune response Antigen presentation by MHC class I
    Development Glucocorticoid receptor signaling
    Selected targets of GCR-alpha
    Signal transduction AKT signaling

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    5/19 BioSystems Pathways for HSP90AA1 (see all 19)
        EBV LMP1 signaling
    NOD pathway
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway


    5/28        Reactome Pathways for HSP90AA1 (see all 28)
        Developmental Biology
    Metabolism
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation


    HSP90AA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/1663 Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1663)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration IEA--
    GO:0003009skeletal muscle contraction IEA--
    GO:0006200ATP catabolic process IDA15937123

    HSP90AA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSP90AA1 for compounds           About GeneDecksing

    EMD Millipore small molecules for HSP90AA1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    10/45 DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    10/113 Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Search CenterWatch for drugs/clinical trials and news about HSP90AA1 / HS90A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1
    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90AA1 (see all 14)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    Sirion Biotech Customized lentivirus for stable overexpression of HSP90AA1 
                         Customized lentivirus expression plasmids for stable overexpression of HSP90AA1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    24/224 DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    2627 AceView cDNA sequences (see top 24):

    T16337 AA369744 BM751979 AA319049 BE772654 BM974105 BE793051 BI861290 
    BU153102 BM771890 BQ638075 BX444743 AI801059 CR607053 BM802957 BM456889 
    AA593911 BP354457 BP364931 AA309988 BM745750 BX429503 BC023006 BQ446823 
    CA422056 BM564793 BX432784 CD675581 AI564565 BU688452 CB134556 CN482865 
    BM771211 BE744069 CB113042 BI559745 BP353451 AI683529 BU158844 BM788422 
    BM835505 BX438647 BM553281 AA249241 BI669430 BP365758 BU735935 BM770103 
    BP354510 BM833745 BP341074 BI464355 BQ883302 AI798322 AI580019 BX443750 
    BP357174 BF173150 AA779056 AI061261 BE834094 AA640476 BM801990 BC000987 
    BE889713 BE790272 BM746030 AA586919 BF983468 BP354234 BM801487 BG395330 
    BP363023 BQ064596 AA457519 CB125743 BU169854 BP354180 BM763718 BG741137 
    H85344 AI468222 BU151252 BP357254 AW498638 AA374728 BM740970 BM770697 
    BP354103 CA419919 BG216655 BM802308 CB132798 BF725727 AW470589 BQ277871 
    AA984886 CB132687 AA323898 CB111454 BX420453 BG339154 AA300666 AA629563 
    BM548872 AI355163 CB161318 BU192039 BM771258 AI630318 BM847345 CD171888 
    CB126787 CB134095 AA371096 AA911271 CB124639 BM998981 BM784370 BM834007 
    BU521144 AU122899 BP341237 AI312946 CB126215 CB122614 BM771150 BG682208 
    BU166257 BE301021 BQ650387 CR605488 AL041434 BP349485 AA846481 BM799197 
    CB126230 BP365739 BP349381 BG706742 BM754651 BG209237 AI434367 BM787588 
    BM746188 CB216345 AA381247 AI889101 BX425177 BG114540 AA586565 BQ879835 
    CB136299 AI718522 BP355481 BM741217 BP340180 AA577378 BM773296 AA599081 
    AV725137 BX439268 BP362990 CB129018 AA335286 CB142582 BQ877032 CB269249 
    BG188540 AI922511 BM825854 BG335218 BM459163 BU620802 BX404036 BM794341 
    BP364747 BG714640 BE792378 BP356728 CB124358 BQ215919 BP363338 CR593964 
    BI601314 BQ688439 AI251771 BQ648886 R17724 BP365680 CD243586 BQ787082 
    AI271539 BQ212247 BM472848 BP361918 CB243663 AA312717 BQ431360 BP371203 
    BQ639882 CA417925 BM827359 BQ937203 BQ028824 BE328211 BG701657 BE905318 
    BM741952 AW768462 AA307837 BU628969 BE882146 BE391169 BQ694748 BM841644 
    BP343000 AI298053 BP353471 CD300351 BF726493 AI049773 BQ228807 BQ687650 
    BM557588 BM752011 BE465714 BU956838 BU552755 BG104196 AA381831 BQ424787 
    BE264421 AA313331 BQ049844 BQ709040 BE895456 BM770727 AW078546 BQ672714 
    CD676554 AI798283 CA419282 BE796387 CR611827 CB140037 BX506426 BM799267 
    BM770690 BM766773 BM806422 CB107094 BE502005 BG191666 BQ069879 BP360563 
    BU178506 AA634683 AI709156 AI459635 BM770113 BP365858 AL705044 AA719731 
    AI640913 BF445828 BM749100 BE901290 BM827045 BM561334 BP355451 BG289548 
    BQ651916 BQ640110 CR599002 BM748494 AA653472 CR610614 BE783147 CA389410 
    BQ720223 BU686197 BM907693 CB124900 BQ650483 BQ890155 AI473900 BQ647746 
    AL043533 CD106194 BM823282 BQ774741 AA552636 BI088872 BP364960 BX458987 
    BP357636 AW613680 BM772069 BM835503 AA617738 BE747401 AA773988 BE151642 
    BF982793 BP358984 AA570011 BQ421675 BP350134 BP356131 BI460668 BU957557 
    BP348618 BM851100 BM770164 BQ431434 AA013209 BQ648360 AA777985 BE744769 
    BM661484 AI878849 AA370644 CR611873 BM770968 F08468 BP351634 BM771876 
    BP363527 BG198289 BQ225225 AI915706 BP364063 BU581404 BU526778 CB152326 
    BM771547 BU145598 AI583541 BM475970 CD513222 CA422318 BX462964 AI299100 
    BE796186 BG391002 CA946401 R29466 AA071048 BQ278816 BM905289 AA984403 
    BM562561 BE018557 BE884453 BM505616 BM771320 BM771152 BE882812 CB129659 
    BG221143 BQ437226 BX423174 CB112685 BM834502 BX418326 CR619460 BQ648656 
    AV660283 BM888106 BQ652761 CB123140 AA314010 AW498642 CF541408 AA234219 
    BP360061 BP372585 BM839745 AI444927 BP354356 BQ689339 AA808379 BQ058567 
    BQ230238 BM771351 BX461517 BM766516 AI334832 CR615580 BM722754 BG482623 
    BM453507 BF794523 BM827807 BE273428 BQ651520 CN483876 BE263688 BP375623 
    BQ432259 BM787498 BM745779 AV708446 BE090288 AA381950 AI376570 CB136175 
    BX447525 BM770685 BG722028 AA320280 BX429662 CB125658 AI082335 BQ424759 
    CA308472 BQ050923 BQ689317 BG292008 BU196611 BE879319 BQ083109 BE732032 
    BE302141 BM834011 BX450093 BQ056381 BG105073 AA988694 BE795839 BQ644475 
    BG822924 CR594716 BP378007 CB134180 CB122939 BQ427532 BM842712 BQ276391 
    BM771163 AI201555 BM844073 CA395677 BE889253 C05220 BP356322 CB116075 
    BE887678 BM978852 BE888198 BM827330 BG777524 BM853435 BP359335 BM834626 
    BQ653704 BM474358 BM770087 BE017983 AV709818 CB148778 CA431938 BU535587 
    AI268569 CD366438 BQ936560 AU126747 BM798215 CB132574 CB132694 BP363688 
    AW302254 BM508981 BQ718338 BQ653287 AI341414 AW151383 BP363032 BQ648560 
    CB158144 BP356104 BQ723338 BP354211 BM787836 CB120885 BQ648064 BU735941 
    AU123681 BE385413 CB133876 BQ882638 AA583125 Z19686 CB136302 BQ931644 
    BG575115 BX646208 BP341978 BM771816 AA865484 BP359526 BU169711 AL043938 
    BQ923652 BQ926539 CB158361 BM771323 BP429471 AA457613 CB134610 BG169410 
    BQ351606 BM756802 BE901945 AI611715 BP349705 BP354342 AL045528 CB143168 
    CD367392 BP353141 BP365313 BQ643276 AA070581 AI143846 BP346832 BI462032 
    AI042136 BE673447 AA312098 BM755572 BP365062 BQ637733 CB131957 BG286938 
    BP364892 CB147496 BM697262 BP353302 BP341404 BU543215 AA478385 AA513695 
    BQ670756 BP354798 BP348501 BM915436 BI670275 BM740919 BG397158 BX464218 
    CB126733 BF724655 AA076019 BM463891 BQ644545 CB134795 AA300826 BE348238 
    BX442082 BP355452 BX421404 BM771415 BQ637596 BQ070476 BP343914 BM460053 
    BQ650162 AI401488 AA662904 BM978802 BM852892 AA740971 BE935721 BX429763 
    BQ932268 N72134 BM794320 BQ056810 BE898989 AI355450 CB112476 BC001695 
    BP363669 AI288092 AA991757 AW117847 CR613014 BP338915 BM050381 BQ646998 
    BM822173 CR596117 BQ717200 BP349341 BQ637106 BM771472 AA026247 CD370291 
    BP350022 BU191161 BP360612 BP357865 BQ679110 BX450559 T16196 AV728233 
    BX408694 CB147677 BQ215456 CD519067 AA666356 BP365517 BM564809 BE747071 
    BM801932 BP352108 AL709992 BQ722786 AA405380 AA375568 BX449722 BQ651961 
    W02709 BQ278939 BX437631 AI587534 BP348155 BM468465 AA353916 BU956268 
    AA488124 AA829914 BG675969 AA397370 BQ685380 BP350083 BF204760 BE787782 
    BU181630 BE549867 AA629423 BG474613 BM770204 CD369784 AA773063 BF793825 
    CB125430 BM770054 BU167848 BP357063 AU076823 CD358934 AW341770 BM827355 
    AW085674 BP349366 BU179452 BG202376 BP355457 BP337047 CB134656 BM844731 
    BP356585 CB133855 BU687394 BP362207 BX410474 AI335809 BM833702 CA748788 
    BM771947 CB106878 BM475205 BI253585 BQ646790 CD243399 BM760149 AA301216 
    AA301285 BU175493 BQ423532 BF448028 CB132703 AI056091 BE896513 BQ720448 
    BM789803 BM557327 BQ686689 BP364217 BM787784 BP365810 BE797314 CB143277 
    BU195258 BQ686070 BM827085 AI015385 BP363421 BQ716766 BQ651041 BI856817 
    BU688393 AW572506 BP353188 D57328 BP356116 AA496907 BG575099 BP351143 
    BP363467 AA903458 BE252341 CD300585 BU185701 BQ670638 BM697255 AI984720 
    BQ918848 BU631732 BU857171 BM981119 BU929327 BX247955 AA364478 CB120517 
    AU122898 CB112532 BP342547 CB122471 BM761115 BM741834 BP349697 BM832717 
    CD557163 BM799387 BE274256 CB132719 BX345539 CB123508 BP373289 BM833582 
    BE300873 BU509076 CB134106 BM553831 CR621835 BE793879 AA968767 BX462517 
    BG761824 AA340224 BP365769 BM762552 BP356997 BP366065 CR604052 AA362041 
    BX421248 AA357095 AA629744 CB147640 BM770089 BX449873 CB125295 BP363052 
    F08576 BI547743 BM792103 CB124367 AA629775 AW589959 CR623660 BI855905 
    BP357786 BP359238 BM835674 AA806023 AI167737 BQ775553 BQ066643 BU169696 
    BM787584 BQ233026 BM710634 AW839201 CB215890 BM818131 BX439584 BQ438187 
    AA605055 CB138182 BX248761 BE501582 AU123455 BG110413 AA318966 N56874 
    BQ773951 BM771898 BP334337 BP360734 CB134959 BM556606 BG393826 AI650434 
    AA059021 BI492909 BM479754 AA381317 BM771405 CB126322 BQ434401 AA937732 
    CB121606 CB134176 BP348522 BU676936 AL044323 AW732111 CD677111 CB215018 
    AA748157 AI707926 BM787542 CR589993 CB154325 AA653657 CB145935 BF984401 
    BQ946011 AA314167 BM193359 BU431687 BP368514 AJ715028 CB999080 CF147283 
    BP366989 BM819130 BE383723 BM838322 BM763379 AW273526 CA393189 BI870587 
    BP365038 BX381060 BP356752 BM740981 AA171758 BI596578 AA402284 AA679253 
    BX646864 BQ221228 BM751858 BQ020503 BP343950 BI117278 CA420189 BM833047 
    BU165439 BG291324 BG756408 BX407775 BG035664 BM745738 BE267266 BG502440 
    BE799410 BU958911 BM016093 F36751 BP365671 BX408175 AI468968 AA320116 
    BP363937 BM796525 BG288987 BP365335 BE740859 BU626011 BQ351736 BP358805 
    BG614604 BP365326 BQ048993 BU860914 BM835712 BI258801 BF337005 BM704177 
    BP341144 BU171689 BU678266 BE868465 BQ718134 BP348787 BQ772555 AA708498 
    BU145858 BQ953366 BP360469 BP339139 BM834363 BM045296 BM471509 BP357449 
    BM835423 BP349643 BX404657 BG428808 BC007989 BP347238 BX407458 BP361334 
    BP360795 BP359102 CB120653 AA357253 BQ319043 BP370170 BX406667 AA303631 
    AW673676 BQ436727 BX387984 BU192493 AW071112 BE895466 BE741577 BM835692 
    AA381564 CA422230 CB135332 AA132704 AA351665 AA630369 AU126227 BM449943 
    T27391 BP363788 BE785041 AI808104 BP357213 AA679491 BP354778 BU172200 
    CF122122 BQ938167 BM976663 BE540478 BP365449 AL045961 BG289859 AA361608 
    BP360074 BU782867 BP352753 BM472864 BP355246 BE794630 BE535845 AI859281 
    CA446986 BP349252 BM009912 AA316195 BM754653 CF126651 BP363934 AI003330 
    BM741947 BF688223 BG620390 CA441408 BU674727 BP364859 BM827598 BM770680 
    BP351305 BX450764 BG615754 BQ232433 CB998808 BG027434 BP363463 BM842950 
    BF684109 BP359120 BQ878293 CD364858 AW057643 BG214461 BG200735 AI969532 
    BG341494 BM047388 AA773161 BI860660 CD642508 BX411091 BQ894635 BQ685091 
    BG180963 CB152257 BU630012 BP342280 BP364310 AI630519 BG284408 BM828617 
    BQ676204 CB148113 BE899252 X07270 BU687472 BQ360396 BP366283 BP364692 
    BG215547 AA214035 BU521703 BF205554 BX326017 BQ314685 BE280814 BM679591 
    BG427434 BE265118 AW023404 BE315127 AI571459 BQ276361 BU538672 BP356175 
    BP353109 AA383729 BM832464 BU174037 BG541817 N47762 BF026023 BM909923 
    BG491269 BQ351893 BP363598 BE793037 AA644346 BE391279 BG186462 BP355575 
    AA306976 BM353379 BQ683437 BQ340541 BP375807 AA778423 BE315545 AA312400 
    CB133779 F09961 BE780376 BM090832 BP354278 CD300733 BQ214952 CA395053 
    CB124533 BP364194 BX408060 BU856916 BM755674 BM462689 BG198125 CB123974 
    BQ717290 BE561569 BM835481 BQ879999 AW272310 AA308606 AI000357 BG472704 
    BF221833 BG024230 CA439337 AI272184 BP364521 BP381918 BE744252 AA099074 
    BE741417 BQ775638 BF035067 AA356486 CA395866 CB853790 BQ682726 AA320302 
    BG403704 BX953123 BP354481 AI539592 AW264114 CB134075 BP356281 CD105385 
    BG291970 BQ230557 BF036642 BP364718 BP357373 CB139283 BP363589 BU166480 
    BI597025 AA120908 BQ071906 AW571560 BU685827 AA191282 BP354860 BX452882 
    AU123157 BU676981 BP360936 BQ440415 BM504491 BX450399 BF038655 BG290828 
    BP356890 BM836527 BG723783 BG756323 BP353937 AI089281 BM834226 BX450544 
    BU682388 BP354730 BI548244 BG289676 BF438506 BG574789 CA418368 BP355935 
    BE266356 BG185911 BX449730 BG714859 BM005757 BP361930 BG745446 BQ638414 
    AA360913 AI207707 BU689173 BM090654 AA307671 CK002723 BG388282 BG612887 
    BE276457 BE891315 BP353400 BE538745 BP354204 AA630652 BX400070 BE536707 
    BG473460 BX408742 BE253510 AA307057 BE888254 BF025820 BQ231715 CD244499 
    BF975201 BU194091 BE903080 CF146559 BG292357 AI094164 BX494275 BG827229 
    BF026049 BP364697 BP380620 BQ774768 BE272063 BP360900 CB112801 BE878706 
    BQ056805 BM771234 BP375297 BM796404 AI803387 AW245186 BP341192 BM556629 
    BG774144 CB136142 AA706279 BP356124 CB124187 BM999305 BM014625 BM787583 
    AA482327 AA216434 AW902632 BQ222889 BG282141 BG547132 AJ714902 BP349361 
    BU157539 BQ722147 AA364389 CF780809 BX439717 BQ775921 CA420816 BI551485 
    AI983238 AA223171 BU932356 BP359543 BE780700 BE894631 BP354624 BE780815 
    BE294066 AV725438 BU629329 CD356450 BP354074 BE876023 AI092228 AA857523 
    BP357051 BM835671 BG397902 BE741698 BE268081 BM742799 BM549980 BG942842 
    CD642974 CB147635 BU845052 BM838778 BG324799 CB998913 BE264030 BP363719 
    BM014443 CF541173 AA626744 BP348963 BE301149 BP353773 BI117307 BG421056 
    BP355864 BM741434 AW769841 BP355647 BE874493 AI630175 BP372812 BG285004 
    BQ348771 BQ232742 BG547406 BM787678 CA315060 BQ351756 BP356764 BF979284 
    BU950192 BQ719635 BE882463 BP357436 BX414082 BU942049 BX408544 BG281933 
    AW498915 BG397826 BP355908 BM788626 BX458092 CK001974 BI860505 BP359166 
    AA093560 BG104287 AA353064 BQ688036 T08937 BM835566 BP355186 BE388737 
    BM852436 AW162634 AA134010 BE789184 BP371075 AA339747 BE892001 BG257351 
    AI474479 BP335136 CA446614 BX408809 CB132707 BX408743 CB134344 BQ958515 
    BM542657 AI623359 AI003357 AI680181 BI858531 BU857701 AA314095 BQ427554 
    CB135693 AI952706 BM832992 CD640012 BF034530 BP354125 CB134187 BG723122 
    BU858503 BF972338 BQ311720 CF993948 AA497069 BU160494 CB106340 BI117010 
    BU945555 CB119871 BQ680893 AW513639 AA356714 BQ940560 BP355760 AW469463 
    BI458380 AA306826 BM904495 BM468469 BP361839 BP355540 BQ217159 BX429893 
    BM784893 BG340227 BM835662 BP365520 BM750748 BI461007 BU630061 BM792563 
    BQ959832 BE782936 CA417640 BG570579 H99923 CD103125 BU146752 BX429146 
    CB134356 BG772363 BQ433859 BE276298 BP356709 BQ880307 CB163921 CA419296 
    BE276535 CB134332 AI422887 BF128634 BQ440818 BU195296 BM792191 BM781865 
    BE901228 CB152057 BG336997 BQ691587 BE885743 BU179681 BQ429507 BM758521 
    BP358742 BX429400 BG338310 BM751251 BG284104 BG759642 BP350794 BP358050 
    BG283102 BG283935 BM755216 BP347736 BX407806 BF308231 BP349602 CD300070 
    BP345936 AW249642 AA310695 BE207495 BG545698 AW675456 BF174989 AU122886 
    BE892481 AW518825 BM006618 BE727316 BP365055 BE266762 AL044324 BP355554 
    BX443003 BX450190 BP354441 BP348628 AA323607 BE268044 AA703828 AI735365 
    BP361312 BP355454 AI818880 AI816296 BM799253 BE386388 BF025892 CA417967 
    BE882990 AA921967 BM511980 BQ775724 BM751868 CA417103 BX478917 AI005344 
    AI065000 BQ646505 BM771143 AA703772 D56121 BI462467 BX429017 BI857860 
    AI266215 BM460711 AA319883 BE384187 BE889602 BM845769 BI599852 BG025312 
    BU542097 BG565941 BM046393 BX429016 BP363565 CF139473 AA666249 AA370165 
    AA370504 BX408659 AA587981 CB135370 N50947 BG751168 CD106877 CD251848 
    BE777964 BU674816 AW503031 BP374826 BX462405 BG255545 BP361295 BG421722 
    CK003809 BG497557 AA548565 BM460113 CB112960 BM450631 BP355109 BF980555 
    BG395366 BE221359 CD105178 BE266239 AA371492 BM552623 CA412078 AA171998 
    BG180775 BG189060 BX506465 BP363586 BG681060 F27287 AA374231 BF314704 
    CB164057 BX434560 BG171332 BI159911 BU542070 AA644668 BU167557 BU838705 
    BP364605 BI224350 BP366204 AI016543 AA357454 AV756334 BG828134 BE901519 
    BQ351716 BP366046 BG184335 AI377472 CB132857 H84679 CB144577 BM833040 
    BM817677 BG699612 BP353402 BP355677 BQ351725 BU674027 BP360473 BX408321 
    AA370456 AK056446 BM828361 BQ653966 BM843569 BI600423 BF974362 BP364434 
    BM014389 BU508282 BI464350 CA415013 CD643121 BU615165 BG566910 BX429865 
    BM845485 BG748114 BG574690 BM833049 BM835449 BI464443 BQ350320 BG756223 
    BP377994 BQ926636 BE707294 BQ439853 BM974607 BE889051 CD110324 BG255340 
    BI117018 BQ645817 BU943935 BP369342 BQ230351 BG030941 BP350266 BG574952 
    BF686109 BM982326 BP357862 BP337734 BG104825 CB989811 BF674008 BQ278199 
    BF038736 BE272716 BM833525 AI201790 BG772644 BU941176 F28496 BQ268388 
    BG200356 BU631792 BX406883 AA306270 BE256139 BU189219 BU155644 BM837058 
    BP380713 BM721168 AI581146 BE393310 BQ639161 BI551942 BG477845 BF025862 
    BG772226 AA353752 BM470403 CD557527 BE893586 BE384808 BQ897317 CB115080 
    AA984694 BE744275 BM852900 CD105800 CB305999 BU164481 BE744566 BM310052 
    AA513807 BM750040 BG191034 AI890897 AI719356 BP365872 BG547687 BQ310971 
    AA132815 AA026444 BG424774 BX429329 BX419794 BE730766 BM453635 CB122800 
    NM_005348 BP364565 BP366309 BU686526 BP365071 BQ351934 AL038129 BP354681 
    BP339770 BM787879 CK004221 BQ222901 BP372818 AW161068 BG478839 BQ026788 
    N41314 BG719543 CD557018 BP365312 BP365906 AW514752 BE382772 AI081361 
    CK024097 BQ688846 CB134090 BM789194 AW291073 BP355906 AV705885 BP364405 
    BU194668 BI438939 BG424451 BM009954 BQ691908 AW780228 BQ360171 AW902548 
    BX496316 BI596554 BG286966 BM759527 BP346192 BE386278 BP355462 BU950480 
    BF038555 CA443465 BI559881 BI850721 BM046384 BE744862 BG167405 BP349428 
    BI465070 BM789447 BM745761 BP363718 CA418071 BM046400 BQ343701 BX367632 
    BQ420439 BX420477 AA356840 BQ424753 BP352144 BM821862 BM787553 BU538137 
    BE901924 BX429293 CK024012 BQ351610 BP354532 BG424330 BE742334 CD359890 
    BP353116 BX450050 AI816457 BM973982 BP353246 BG104205 BE501669 BE735758 
    CF140337 BE897016 CB132365 BX451852 BM749614 AW571632 BM743378 BG472184 
    BE744444 BP361901 BF686544 BM006074 BQ694576 BM465777 CB851315 BX408017 
    BQ217096 BE298818 BG718990 BQ918361 BP349380 BE780007 BP363744 BX421977 
    BM750463 BM833880 BM835155 BQ351616 BX462356 BX325777 BG677512 CB961584 
    BX425456 BE275314 AI032857 BU556882 BP353968 AL710682 BP349633 BX429873 
    BG255991 BI089071 F04787 BE787174 AI580322 BQ947778 BU155756 BU732620 
    AA599238 AI962866 BM794800 AA666061 BU944640 BP357711 CB988207 CF455720 
    BE292794 AI338430 BX449814 BQ706145 CD109731 BG291915 BM781449 AW168775 
    BU177948 CB134593 CA417821 BQ064487 BQ005716 BQ776250 BF685851 AA120909 
    BI816693 AW149862 BE622572 BM475063 BX434332 AV649676 BX429367 BP355310 
    BP364338 BG179584 CB961248 AI401635 BM827702 BG771608 BU933219 BG339431 
    BE797111 CD102650 BQ351892 BF698935 BE541056 CB135862 BP349807 BF797661 
    BU933549 BP349332 BG913640 H94609 AJ714083 BQ694564 AA133890 BQ924340 
    BG205395 AW161279 BX952212 BU190844 AI880522 BI093337 BI562093 BP364267 
    BM787724 BM833537 BX450262 BQ351751 AU123790 BP365535 BG753150 BG289647 
    BG620186 BI547467 BP350509 BE621978 BP349364 BX440283 AA301229 BG420237 
    AV756792 BM955671 BF979822 BM819186 AA827522 AA669137 CB123132 BI089367 
    BE793288 BF026846 BX460056 BP365377 BM754083 BG705954 BM790221 CB152885 
    BG031692 BI597709 BG479257 AA339411 BG261316 BM765395 AA320835 BM827838 
    BP356437 AA699607 BP356519 BP377964 BU195567 BM827964 BU167259 BE795929 
    BQ689485 BE895803 BQ223489 CA440454 CB988109 AA229107 BP355107 BG761594 
    BG530549 BQ231785 BP347975 F29908 CB128594 BP382651 F27516 BX423094 
    BP337493 BE549418 AW157708 BE784768 BX429886 BQ646742 AW615324 BX424913 
    BU509561 CA417560 BP383463 BE780823 BP363216 BG740397 BU687745 BQ351607 
    AA371459 BX408319 BI869349 BG339697 BX347362 AI922501 AV707039 BQ677380 
    BX450351 BG681395 BQ426004 BF026863 BG336589 BU171509 BP340789 BU193760 
    W76644 BE177723 BP363387 BQ348772 AI859951 BE894580 BU154145 AA076020 
    BI115963 BP365267 AW572409 N34251 CB143989 BX403839 BX408167 BF032941 
    BM015978 AA300804 BQ441067 BM469186 BF973255 BE264128 BU542725 BX641634 
    AA683206 BG326918 BG761047 BM006640 BP364693 BF309384 BX407811 BI561300 
    AI371186 AI174842 BQ943392 BM558627 AI886733 AI926828 W73056 BU171768 
    BX450714 BQ231349 AV728908 BP362570 BQ921749 BM017471 BP355010 BP339584 
    BM834150 AA306893 AA383060 AW902549 BE395967 BE709875 AI924799 AW769840 
    F04690 BQ351705 BM834412 BG291922 BM770755 CB409232 BQ437648 BP347759 
    BP355317 CA418135 AJ713393 BI603518 BG117726 BG195778 BP363383 BP346903 
    BU600536 BG196262 BP381953 BF343519 BQ690319 BU623165 BP356345 BP347407 
    BM090880 AL705103 BX413706 BP372802 BX446993 BX408660 BE734269 BU543868 
    CD522337 CB961329 AA334804 AA626817 CA424392 BM793683 BI546603 BM762068 
    CD512377 BI088137 BG419926 BU176685 BX428746 BG180070 BP349360 CB216341 
    BP349081 BG675007 BE898524 BM827984 BG284836 BG024612 BU681406 AJ707187 
    CB131968 BM770979 CF128086 BP375817 BP363377 BX495613 AA991804 BG287252 
    CB409432 BX408889 BQ775147 BX450651 BP368276 BP354772 BX408485 AI687004 
    AI954471 BG220675 BE278240 BX450684 BG615180 BU194003 BQ323764 BM462658 
    AA985112 BP364069 BP354149 CB409511 BP359706 BM835441 BE410080 BF973561 
    BE716035 BM745318 F03806 BP354974 BP353455 BP349769 BE677551 BM745597 
    BG163650 AA419412 BF972290 BP379057 BM839633 BG532378 AW084778 BQ774002 
    BP354689 BX459988 BE897273 CB143565 F22795 AI184461 CB962103 AL121253 
    AW403943 BM759085 BG778350 CB156030 BX470282 BG677196 BP366984 BG112522 
    BU162735 BG334594 BG325387 BF751036 BE795628 BP346936 BM041939 BP363204 
    BI562341 BQ946092 W56527 BU508632 BX411092 AA725103 CA406303 BQ438105 
    CD513906 BQ685997 BG326343 BM090605 BP380622 AJ713652 BQ684434 BX438531 
    AA375987 BG193239 AI394675 AA315439 BG200354 BP350963 CB961585 BU169266 
    AA708235 BE268085 BF315264 BG290197 AA206075 AA235842 BG170970 BE892885 
    BP364725 BM817439 BM836062 BI857054 AL047200 BP345107 AA380967 CA440452 
    AI814212 AA331252 AI902943 BG392631 BM745285 BP363248 BI560266 BG034614 
    BE278498 AA602299 CF139933 CD102005 BE272291 BG290965 BG740127 AA356627 
    R29731 AA316587 BM835656 BQ008757 BQ057059 BE075923 BG194253 BF204764 
    BF686286 BQ227711 AA312386 BP348084 AW339156 BQ689868 BI870095 BG720871 
    BP352291 BI088544 AA351203 AI742363 AA214083 BP359443 BM976869 AI925796 
    BI546871 W56591 BP357405 BM787451 BP364607 AA991208 BG754077 BG875921 
    BP363936 R52323 BF983066 BQ951837 BG696742 BM793259 AA310601 BG184330 
    AA192385 BE901220 AU279662 AA774999 BM464756 AA365777 AA502598 CB118720 
    BP364350 BI600054 AA563811 BU179638 AI311913 CA445435 BQ213099 BG708576 
    BG338786 CA418209 BM822192 BG254833 BF128762 AA305037 BX328801 BU729713 
    CF995684 BE874820 BX408557 BM558376 BQ636100 AA704189 AA383454 BF576079 
    BE302151 BQ317558 BE542334 BC017233 BF036446 BM751997 BQ071421 BU163401 
    CB114936 BF037018 BX408795 BQ679117 AI380044 BE799905 BG616242 BX485754 
    AW149906 BF975974 BX500541 BP362353 BX450534 AA578660 CF144702 BI553926 
    BP348949 BM680263 AA129370 BQ438205 BU933081 BE385779 BG699496 CF594107 
    BE893889 BQ896636 BP355969 BU595042 BX438704 BM504273 CF785936 BM835710 
    BG248669 BF103833 BP355336 BG389458 BM755541 AI799397 BU942308 BX422652 
    AA668543 BP364996 BM771431 BM542703 BE891640 BE877044 BP357675 BM787476 
    AI110792 BG701752 BQ691270 BG699179 BX495971 BM976034 BG029407 BQ935401 
    BE536491 BM835757 AI096990 BG403752 T08862 BE889647 CA423232 BP358744 
    BU539215 CN485036 BF026296 BQ006474 BQ045432 CB158569 AW672867 BP355744 
    BE743429 BE890715 BQ719459 AF074699 BF034628 CB114441 CK000235 F36820 
    AA564649 AA371200 BU789208 BG418985 BG434834 BU951773 BU189393 BU521376 
    BP363254 BQ049305 BP364843 BM829499 AV688833 BM829007 BP351167 BE501656 
    AI090489 BG708051 AI347442 AA364614 BF037183 AA333236 AV714108 AI685234 
    CK003121 BU553466 BE887720 BM751684 CD300374 BQ775119 BM787749 BP336361 
    AA568731 T49737 BM811462 BU594684 BQ877018 AW081635 CD243970 BQ775547 
    BP354339 BE048702 BX416309 BP355412 BP350738 BM452892 BG686714 BP371119 
    BG429782 BE886493 BQ432799 BP354469 BX429290 BP365857 BM771162 BP362618 
    BG480678 BM798416 BU508375 BI460801 BM832731 BM794262 BE741489 BX428767 
    BI869557 BM479916 BP363394 AL038130 CD512397 BX340856 AI089273 BG569320 
    BM770961 AA372480 BM751888 AI174952 BE786120 BE879242 BQ642828 BM827660 
    BX445552 BP365230 AI744717 AA629891 BP364379 BP365712 BU182116 AI375668 
    BM835843 BM984767 AA086423 BQ638645 BP364078 BM353224 BG325276 BM564713 
    BP344055 BE613850 BF208054 BM459146 CD356101 BX478367 BG260362 AL046504 
    BF448035 AA357506 BG178464 BE790647 BP372190 BP337342 BI597751 BQ351666 
    BM834939 BQ876420 BM457327 BI600585 BU160618 BP364031 BE743661 BU781967 
    BX429748 AA985095 BX438139 BP358136 BM853647 BM832526 BM833513 BX429937 
    BM787270 BQ005714 AI954116 X15183 BU158742 BU958743 BE408286 BM828369 
    BX487201 BG528922 BP361190 AI090696 BM470436 BX450175 BU158444 BE269673 
    F12340 BP356255 BE792969 AU129848 AA130815 BM745590 CA448560 BU597108 
    BG530606 BP346189 BX416351 BQ775989 BM829208 AI352264 BG776818 BP337701 
    BE742826 AA565553 BU185532 BM794909 BP383256 BI117290 BU507450 BQ278328 
    BM789129 BF686119 AV652506 BM749102 CB140669 CD244989 AA365619 BG393123 
    CB114672 BP345814 BQ681826 BM796037 BE881191 BM839422 CF126448 BU177028 
    BU188596 BX410473 BX449761 CB136178 BP353723 BP366094 BG204984 BQ639029 
    BX449987 BM745923 BP355353 BG207603 CB148676 BE728427 BG480206 BQ694825 
    BP360072 CB160280 BM471694 BM794250 BE888053 BE887364 AW150199 BG717081 
    BP356847 BM750399 AK129557 BG944658 AA552549 AI979099 BM749151 BP361425 
    BX387983 CA417837 BE744684 CB136126 BQ378484 BE299233 AA223172 AA099565 
    AA013363 BX450468 BX455227 AA356106 BE887391 AW388972 CD642932 H85198 
    BG037050 BU147213 CF139787 AA244154 BX429074 BF688608 BM146435 CN479227 
    BI551637 BE787672 BE614457 BM424217 BG528988 AA112734 BX450871 BU165201 
    BM689490 BG185910 BM042528 BG200355 BE302661 BG187992 AA192634 W00382 
    R54487 BG197250 AW663290 BX408222 BX347352 BF129778 BE966696 BE967085 
    AA214188 AA206255 AI879407 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)      HSP90AA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTAGTCCT
    HSP90AA1 Expression
    About this image


    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Kidney (Urinary System)
             visceral organ/metanephros/renal cortex   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/metanephros/renal cortex   
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal

    See HSP90AA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSP90AA1

    SOURCE GeneReport for Unigene cluster: Hs.525600
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.3(n)1
    99.18(a)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.37(n)
    96.43(a)
      423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    HSP90AA16
    Uncharacterized protein
    96(a)
    82(a)
    possible ortholog
    1 ↔ 1
    GL343232.1(1912641-1921714)
    GL343742.1(74458-74844)
    zebrafish
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    78(a)
    1 → many
    3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-216
    Heat shock protein 90
    77(a)
    1 → many
    V(14684918-14688543)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4
    HSP821
    Cytoplasmic chaperone of the Hsp90 family, redundant more4
    Hsp82p1
    62.96(n)1
    64.05(a)1
      13(632355-634472)4
    8558361  NP_015084.11  8552244 
     NP_013911.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP90.11 heat shock protein 81-1 66.81(n)
    73.81(a)
      835341  NM_124642.3  NP_200076.1 


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSP90AA1 gene
    HSP90B12  TRAP12  HSP90AB12  
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    HSP90AA1 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1394 SNPs in HSP90AA1 are shown (see all 1394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679323211,2
    C--82751808(+) TTTTT-/TT/TTT
            
    GAGAC
    1 -- int11NA 2
    rs556835511,2
    C--83556227(+) TTTTT-/TTT/TT
    TT
    /TTTTT
    GTGAC
    1 -- int11NA 2
    rs22774661,2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSP90AA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670326CNV Deletion23128226
    nsv1428CNV Insertion18451855
    esv25342CNV Loss19812545
    nsv832879CNV Loss17160897
    dgv25n68CNV Loss17160897


    Human Gene Mutation Database (HGMD): HSP90AA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90AA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 140571    OMIM disorders: --

    20/128 diseases for HSP90AA1 (see all 128):    About MalaCards
    hand-foot-genital syndrome    lobular neoplasia    neuronal intranuclear inclusion disease    candidiasis
    atypical teratoid rhabdoid tumor    dopa-responsive dystonia    rhabdoid tumor    primary hyperoxaluria
    gastrointestinal stromal tumor    anaplastic large cell lymphoma    mixed cryoglobulinemia    varicocele
    testicular cancer    macroglobulinemia    cryoglobulinemia    polymyositis
    waldenstrom macroglobulinemia    dermatomyositis    rheumatic disease    peutz-jeghers syndrome

    3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    HSP90AA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/91 Novoseek inferred disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Genetic Association Database (GAD): HSP90AA1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 9 sources (see all 1977):
    (articles sorted by number of sources associating them with HSP90AA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (1998)
    4. A proteomic investigation of ligand-dependent HSP90 c omplexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (1998)
    6. Hsp90 is regulated by a switch point in the C-termina l domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (2009)
    7. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A....Lamas S. (2005)
    8. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (2003)
    9. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (2009)
    10. Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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