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HSP90AA1 Gene

protein-coding   GIFtS: 70
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
  See HSP90AA1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifier: GC14M101619

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene:
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and neuronal intranuclear inclusion disease. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search Chromatin IP Primers for HSP90AA1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

102,547,075 bp from pter      End:
102,606,086 bp from pter
59,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1,
HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with
AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for
correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts
with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding
motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
Selected PDB 3D structures from and Proteopedia for HSP90AA1 (see all 166):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • Ubiquitination2 at Lys58, Lys74, Lys84, Lys112, Lys153, Lys185, Lys191, Lys209, Lys224, Lys283,
                                 Lys292, Lys294, Lys314, Lys327, Lys362, Lys407, Lys419, Lys436, Lys443, Lys446 (see all 27)
  • Modification sites at PhosphoSitePlus

  • See HSP90AA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
    Reactome Protein details: P07900

    HSP90AA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HSP90AA1 (HSP90 alpha)
    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins for HSP90AA1
    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1
    OriGene Custom Protein Services for HSP90AA1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for HSP90AA1 

    antibodies-online proteins for HSP90AA1 (11 products) 

    antibodies-online peptides for HSP90AA1

    GeneTex Proteins for HSP90AA1:  
                        Heat Shock Protein 90 recombinant protein (GTX65117)

    HSP90AA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies for HSP90AA1
    OriGene Custom Antibody Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 (P08238, P07900)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HSP90AA1
    antibodies-online antibodies for HSP90AA1 (168 products) 

    GeneTex Antibodies for HSP90AA1:  
                        HSP90AA1 Antibodies

    HSP90AA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90AA1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for HSP90AA1 (HSP90 alpha)
    GenScript Custom Assay Services for HSP90AA1
    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSP90AA1 
    antibodies-online kits for HSP90AA1 (29 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family

    Find genes that share domains with HSP90AA1           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding ----
    GO:0002135CTP binding ----
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI12526792
    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with HSP90AA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       genOway: Develop your customized and physiologically relevant rodent model for HSP90AA1

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for HSP90AA1

    miRTarBase miRNAs that target HSP90AA1:
    hsa-mir-25-3p (MIRT050304), hsa-mir-30c-5p (MIRT047953), hsa-mir-30e-5p (MIRT044155), hsa-mir-186-5p (MIRT045178), hsa-mir-183-5p (MIRT047124), hsa-mir-421 (MIRT039416), hsa-mir-501-5p (MIRT041140), hsa-mir-378a-3p (MIRT043944), hsa-mir-3943 (MIRT052896), hsa-let-7b-5p (MIRT052238), hsa-mir-324-3p (MIRT042829), hsa-mir-425-5p (MIRT039331), hsa-mir-484 (MIRT041642), hsa-mir-204-5p (MIRT047015), hsa-mir-222-3p (MIRT046648), hsa-mir-1226-3p (MIRT036428), hsa-mir-16-5p (MIRT031959), hsa-mir-375 (MIRT020063), hsa-mir-760 (MIRT036729), hsa-mir-185-5p (MIRT045325), hsa-mir-17-5p (MIRT050979), hsa-mir-10a-5p (MIRT047507)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1

    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for HSP90AA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA1 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    HS90A_HUMAN, P07900: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    plasma membrane4
    endoplasmic reticulum3
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for HSP90AA1 About   (see all 58)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    3Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82
    vRNP Assembly0.00
    4Metabolism of nitric oxide
    eNOS activation0.00
    eNOS activation and regulation0.00
    Metabolism of nitric oxide
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.00
    5Signaling by FGFR
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR in Cancer0.82

    Find genes that share SuperPaths with HSP90AA1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    Selected BioSystems Pathways for HSP90AA1 (see all 20)
        NOD pathway
    EBV LMP1 signaling
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway

    Selected Reactome Pathways for HSP90AA1 (see all 15)
        vRNP Assembly
    HSF1-dependent transactivation
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Scavenging by Class F Receptors
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat


        GeneGlobe Interaction Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration ----
    GO:0003009skeletal muscle contraction ----
    GO:0006200ATP catabolic process IDA15937123

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AA1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    Selected DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Find genes that share compounds with HSP90AA1           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1
    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    Selected DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    2627 AceView cDNA sequences (see top 24):

    BP354234 BM839745 BG393826 BQ685380 BX438647 BP357786 CR623660 CD358934 
    BM833745 BU581404 BM771323 BM770685 BP429471 BM771415 BM745750 BM792103 
    BM557327 BP363023 BM770054 BP365062 BU145598 BM818131 AI015385 BP363421 
    BU735941 BU687394 BP375623 BU175493 R29466 AW839201 CB152326 BP359335 
    BP363338 CR593964 BI601314 BQ688439 AI251771 BQ648886 R17724 BP365680 
    CD243586 BQ787082 AI271539 BQ212247 BM472848 BP361918 CB243663 AA312717 
    BQ431360 BP371203 BQ639882 CA417925 BM827359 BQ937203 BQ028824 BE328211 
    BG701657 BE905318 BM741952 AW768462 AA307837 BU628969 BE882146 BE391169 
    BQ694748 BM841644 BP343000 AI298053 BP353471 CD300351 BF726493 AI049773 
    BQ228807 BQ687650 BM557588 BM752011 BE465714 BU956838 BU552755 BG104196 
    AA381831 BQ424787 BE264421 AA313331 BQ049844 BQ709040 BE895456 BM770727 
    AW078546 BQ672714 CD676554 AI798283 CA419282 BE796387 CR611827 CB140037 
    BX506426 BM799267 BM770690 BM766773 BM806422 CB107094 BE502005 BG191666 
    BQ069879 BP360563 BU178506 AA634683 AI709156 AI459635 BM770113 BP365858 
    AL705044 AA719731 AI640913 BF445828 BM749100 BE901290 BM827045 BM561334 
    BP355451 BG289548 BQ651916 BQ640110 CR599002 BM748494 AA653472 CR610614 
    BX442082 CB131957 BM827355 BP346832 BM852892 BQ689339 BM771152 BQ423532 
    BM827330 BU169711 AA593911 AL043938 CR596117 AA397370 BP364063 BQ637733 
    BP373289 AI056091 BU686197 BQ720223 BQ936560 CD366438 BG474613 BP378007 
    BX421248 BM801990 CB148778 BP364217 AI288092 BP363669 BX449722 W02709 
    BM741834 BM710634 BM479754 BI464355 BE747071 BM562561 BE884453 BE018557 
    BQ651041 N72134 BX429503 BI669430 BM787584 AW117847 BP365758 BQ424759 
    AI082335 Z19686 AL044323 CB124900 BM835503 CR613014 BE882812 BP365810 
    BM787784 BM833702 BM564793 CB129659 BP348522 AA026247 D57328 BM833582 
    BQ066643 CD557163 BM508981 AW302254 CB138182 AA605055 BQ923652 BE732032 
    AA381950 AA300826 CB132703 BM788422 BE783147 AI564565 BX248761 T16337 
    BM798215 AA583125 AA234219 AI143846 CB147640 BX449873 BQ647746 CA748788 
    BG575099 BQ650483 BQ653704 BM905289 BQ883302 BX408694 AV728233 AA362041 
    BE834094 BM697262 AA740971 AA488124 BQ278816 BM853435 CB143168 BP365313 
    BM771472 BP354211 BM771547 BM553281 CN482865 BE889713 BP362207 AA806023 
    BC000987 AI167737 BM564809 BP365517 BM789803 BI856817 BP356997 BX450093 
    CR589993 BM787542 BI547743 BP348501 BQ646998 AI583541 BM771898 AA777985 
    BM787836 BM974105 BX423174 BM771947 BP356104 BE151642 BP341404 BX646208 
    BU153102 CB125658 BX429662 AA773063 BQ643276 CA422056 BP348155 AI611715 
    BQ686689 AV660283 BQ648656 CA946401 BI559745 BQ651520 BX461517 BG221143 
    BM770164 AI984720 BM697255 BX439584 BG482623 BM770087 BM474358 BQ773951 
    BE501582 BF982793 BM772069 BP357865 AA662904 BP353302 BX462964 BP349697 
    AA318966 F08468 BE898989 BQ648560 BI460668 BP356131 AA629775 CB124367 
    BF448028 BM756802 BX410474 BF724655 AA629744 BP364931 BQ890155 AI473900 
    CR594716 AI268569 CR615580 BX429763 BQ716766 BM832717 BM835674 BM761115 
    BQ446823 AA375568 BU526778 AA301285 F08576 BM770089 CB145935 BQ644475 
    AA586919 CB112532 BU857171 BX345539 BI670275 AA570011 CB122471 BQ438187 
    BE302141 BX462517 BG761824 BX418326 CR619460 BF984401 BQ946011 AA314167 
    BM193359 BU431687 BP368514 AJ715028 CB999080 CF147283 BP366989 BM819130 
    BE383723 BM838322 BM763379 AW273526 CA393189 BI870587 BP365038 BX381060 
    BQ064596 AA457519 CB125743 BU169854 BP354180 BM763718 BG741137 H85344 
    AI468222 BU151252 BP357254 AW498638 AA374728 BM740970 BM770697 BP354103 
    CA419919 BG216655 BM802308 CB132798 BF725727 AW470589 BQ277871 AA984886 
    CB132687 AA323898 CB111454 BX420453 BG339154 AA300666 AA629563 BM548872 
    AI355163 CB161318 BU192039 BM771258 AI630318 BM847345 CD171888 CB126787 
    CB134095 AA371096 AA911271 CB124639 BM998981 BM784370 BM834007 BU521144 
    AU122899 BP341237 AI312946 CB126215 CB122614 BM771150 BG682208 BU166257 
    BE301021 BQ650387 CR605488 AL041434 BP349485 AA846481 BM799197 CB126230 
    BP365739 BP349381 BG706742 BM754651 BG209237 AI434367 BM787588 BM746188 
    CB216345 AA381247 AI889101 BX425177 BG114540 AA586565 BQ879835 CB136299 
    AI718522 BP355481 BM741217 BP340180 AA577378 BM773296 AA599081 AV725137 
    BX439268 BP362990 CB129018 AA335286 CB142582 BQ877032 CB269249 BG188540 
    AI922511 BM825854 BG335218 BM459163 BU620802 BX404036 BM794341 BP364747 
    BG714640 BE792378 BP356728 CB124358 BQ215919 BU929327 AI376570 BP354342 
    BP355452 CB134610 BP354356 AI444927 CA422318 BG575115 CR621835 BG397158 
    CB136175 BE385413 CB133876 BM794320 BM740919 BU196611 BE879319 BU735935 
    BE263688 BM771320 BP372585 BM771876 C05220 BX421404 BG395330 BI253585 
    BP353188 BP356585 CB126733 BQ918848 CB215890 BX447525 BP352108 BQ230238 
    AA309988 BP357174 BF173150 BM801487 BP360061 BQ083109 BE887678 BG286938 
    CB147496 AI401488 BE017983 AA478385 BU543215 BM722754 AI683529 AL045528 
    N56874 AW498642 BE090288 CB112476 BM834502 CB112685 AI042136 BI462032 
    BG202376 BP355457 BM888106 CR607053 BP338915 BQ722786 BE772654 CB122939 
    BQ427532 BM771211 BP353141 CD367392 AA829914 BQ926539 BQ070476 CD513222 
    BP353451 BQ437226 AA984403 AV708446 CD106194 BF793825 AL043533 BM799387 
    BU688393 AU076823 BM834011 AA937732 CB134556 AL709992 BM460053 BQ679110 
    BQ432259 BM787498 BM745779 BM556606 BM771351 BP358984 BM822173 AA513695 
    BX464218 AU123455 CD300585 BG110413 BG292008 BM553831 BQ689317 BM463891 
    CB134176 AA748157 CB215018 CB116075 BE274256 CR611873 CB106878 T16196 
    BP356116 BM771405 CB126322 BP364892 CA395677 BQ717200 BQ686070 BE889253 
    AA405380 BQ670756 AI061261 AA779056 AA773988 AA340224 AU123681 BC023006 
    CD243399 BQ650162 BU179452 BE252341 AA808379 BU631732 BM751979 CF541408 
    BM834626 CB120517 AU122898 CA431938 BU535587 AW613680 BI492909 AA059021 
    BM475205 BU167848 BU185701 AA320280 AA968767 CD677111 AI878849 BM661484 
    BM844731 BU195258 BQ653287 BP354798 BP356322 BM978802 BP359238 BE796186 
    BG391002 BM770968 AW085674 CD369784 BP341978 BP350134 CB120885 BE793051 
    BP349341 BI855905 BP348618 BU957557 AI355450 BP354457 BM851100 BE744769 
    CB113042 BG169410 BQ233026 BP342547 BP351143 BP363467 BQ276391 CB134180 
    BP341074 BM770204 BQ225225 AA301216 AA457613 AI201555 BE747401 BE896513 
    CB125430 AA013209 BQ648360 BM746030 BQ882638 BM771816 AA865484 BX437631 
    AI587534 BE273428 BM827807 BQ646790 BU191161 BM456889 CB132719 BP363527 
    BG198289 CA389410 BP360612 BU169696 BQ058567 BI088872 BU956268 BX432784 
    AI915706 BP350022 AI707926 CB158361 BM823282 BG675969 BP337047 BQ931644 
    AA076019 BF204760 AA357095 BU676936 AI335809 BQ056381 AW572506 BE935721 
    BX458987 BM915436 AA666356 CD519067 CB134106 CB158144 BQ775553 BQ431434 
    BM468465 CB143277 BX443750 AI580019 BQ637106 BQ932268 BG722028 CA308472 
    BQ050923 BP365769 BG822924 AA991757 BM475970 BQ637596 AA369744 BP349366 
    AA249241 AA312098 BF983468 BE888198 BM978852 BP351634 BQ434401 BM050381 
    CB134795 BM766516 AI341414 BP363032 AW151383 AA381317 BQ644545 BF794523 
    BU688452 BP357063 BM981119 AA370644 CD675581 CB125295 BQ648064 BP363688 
    BE797314 BQ652761 CB123140 AA496907 BQ056810 BM802957 BQ670638 CB132694 
    BE790272 BM762552 AA552636 BP357636 AA364478 BP364960 CB134959 BU181630 
    BE549867 AA629423 BE744069 BQ638075 CB123508 BX444743 BM453507 CB147677 
    BG105073 AI801059 CB121606 BQ723338 AA353916 BP363052 CD370291 AW341770 
    BQ421675 BC001695 BX247955 BQ215456 BM505616 CB154325 BE787782 BP350083 
    BQ651961 AA903458 BQ278939 AV709818 AA070581 BX450559 CB134656 AW732111 
    AA314010 AU126747 AA988694 AA640476 BM770103 BM801932 BE673447 AI299100 
    BM842712 BM771890 AI650434 AI334832 BM835505 BI861290 BM771163 CR604052 
    BM907693 AI798322 CB133855 BM827085 BQ720448 BQ718338 BP360734 AA653657 
    BP354510 BE793879 BE300873 CB132574 BG777524 BU158844 AA319049 BP349705 
    BE795839 CB136302 CN483876 BM844073 BE901945 BU509076 BM760149 BP359526 
    AA617738 BP366065 AW589959 AA071048 BE348238 BQ774741 BM755572 BP334337 
    BQ351606 BP343914 BM771162 BE549418 BF979822 BM821862 BQ351736 BP381953 
    AL047200 BP370170 AA357253 BM745590 AA130815 CF122122 BU172200 BI546871 
    BP337342 BM741947 BP355317 BG913640 BP349332 BM789129 BU507450 BE677551 
    AL710682 BM745597 BG334594 BU162735 BP360469 BP339139 BU539215 BF026296 
    CN485036 BQ775547 BG261316 AA339411 F36820 BP353402 BQ691270 AI744717 
    BP363254 BU674816 BG754077 BE535845 BG472184 AA206075 BP352753 BE744862 
    CB135862 BG497557 CK003809 AI814212 BE395967 AI902943 AA331252 BX407775 
    BG180963 CB143989 BQ943392 AA568731 BX328801 BP356752 BM833040 BP351167 
    BP359443 BP363937 AI719356 BP358805 BX450175 BP356519 BP372190 BP365872 
    BP364350 AA319883 BG291324 H84679 BP364692 BP364996 AA214035 AI880522 
    BX411092 BG170970 BU165439 BP360074 BQ775119 BE890715 BU508632 CB134090 
    BX416351 CD364858 CD102650 BQ005716 AI081361 BF686286 BP348084 AW161068 
    BI562341 BU782867 BQ772555 BE268081 BM742799 BM549980 BG942842 CD642974 
    CB147635 BU845052 BM838778 BG324799 CB998913 BE264030 BP363719 BM014443 
    CF541173 AA626744 BP348963 BE301149 BP353773 BI117307 BG421056 BP355864 
    BM741434 AW769841 BP355647 BE874493 AI630175 BP372812 BG285004 BQ348771 
    BQ232742 BG547406 BM787678 CA315060 BQ351756 BP356764 BF979284 BU950192 
    BQ719635 BE882463 BP357436 BX414082 BU942049 BX408544 BG281933 AW498915 
    BG397826 BP355908 BM788626 BX458092 CK001974 BI860505 BP359166 AA093560 
    BG104287 AA353064 BQ688036 T08937 BM835566 BP355186 BE388737 BM852436 
    AW162634 AA134010 BE789184 BP371075 AA339747 BE892001 BG257351 AI474479 
    BP335136 CA446614 BX408809 CB132707 BX408743 CB134344 BQ958515 BM542657 
    AI623359 AI003357 AI680181 BI858531 BU857701 AA314095 BQ427554 CB135693 
    AI952706 BM832992 CD640012 BF034530 BP354125 CB134187 BG723122 BU858503 
    BF972338 BQ311720 CF993948 AA497069 BU160494 CB106340 BI117010 BU945555 
    CB119871 BQ680893 AW513639 AA356714 BQ940560 BP355760 AW469463 BI458380 
    AA306826 BM904495 BM468469 BP361839 BP355540 BQ217159 BX429893 BM784893 
    BG340227 BM835662 BP365520 BM750748 BI461007 BU630061 BM792563 BQ959832 
    BE782936 CA417640 BG570579 H99923 CD103125 BU146752 BX429146 CB134356 
    BG772363 BQ433859 BE276298 BP356709 BQ880307 CB163921 CA419296 BE276535 
    CB134332 AI422887 BF128634 BQ440818 BU195296 BM792191 BM781865 BE901228 
    CB152057 BG336997 BQ691587 BE885743 BU179681 BQ429507 BM758521 BP358742 
    BX429400 BG338310 BM751251 BG284104 BG759642 BP350794 BP358050 BG283102 
    BG283935 BM755216 BP347736 BX407806 BF308231 BF973255 BM827984 AA301229 
    BF685851 BP363586 BF686544 AA668543 BE743429 BP363204 CB114441 BG424330 
    BF204764 BG171332 CD243970 CB305999 BM852900 BM827964 BE795929 BU167259 
    AJ707187 CB131968 BX325777 BI857054 AA502598 BM465777 CB118720 AV756334 
    BP354689 AI962866 BQ876420 BM794800 AI375668 BP365712 BG325387 BP350963 
    BM833880 BM457327 BG708051 BM754653 BE787174 AA316195 BM009954 BQ436727 
    BQ691908 BI553926 BX478917 BU154145 BF025862 BG772226 BM045296 BG753150 
    BM832526 BM833513 BP346189 BX429748 BG530606 BG248669 BQ049305 BX408167 
    BM833049 BF032941 AA235842 BQ646505 BP362618 CB132365 CF140337 BU597108 
    BU508375 BM751868 BQ775724 BG338786 BQ921749 BP362570 BU732620 AA371459 
    AA708235 CB998808 BP356255 F12340 BM833537 AW672867 BE384808 BI597751 
    BQ775989 BI551942 BM819186 AA827522 BM796525 BG194253 BX450534 BP366984 
    BG112522 CB961329 CD522337 BQ689868 BP347407 CA446986 CA417103 BP349081 
    BI088137 BF038736 AI630519 AI859951 CK024097 BU194668 BP364405 AA086423 
    BX952212 BU190844 BM829208 BG429782 BF034628 BQ918361 BG718990 BP363248 
    AA310695 BG719543 AA171758 AI266215 X07270 BU933081 BP369342 BG195778 
    BQ221228 BQ690319 BX406667 BP365055 BP358744 BE266762 BP349428 BG167405 
    BE278240 AW249642 BM745738 BP345936 CD109731 BM781449 BG291915 BI465070 
    BM745761 BM789447 CB114672 BM974607 BP345814 BX340856 BQ896636 BG740127 
    BM787270 BP363394 AL038130 BE874820 BX408557 BM558376 BM542703 BP363788 
    BG326343 CD513906 BQ351716 BP355744 BM449943 T27391 AA356840 BG024612 
    BP366046 BU192493 BU943935 BQ005714 BQ894635 BE292794 AW161279 BG205395 
    BE501669 BG772644 BG104205 BQ719459 BP355107 BM837058 BP342280 BU630012 
    BE272716 AW518825 BM006618 BM843569 BI600423 CD106877 BG751168 CA448560 
    BE207495 BG180070 D56121 BM835692 BF448035 BE741577 F04787 BP377994 
    BQ926636 BX450764 F28496 BU623165 CB132857 BE075923 CK004221 BG215547 
    BP361312 BE897273 BI599852 BP352144 BG220675 BG117726 BM047388 AA563811 
    BI600054 BX450351 BG681395 BQ426004 BU687745 BQ351607 BM755541 BF343519 
    AV728908 BX450714 BX429329 BE882990 BG424774 BE895803 BE541056 BM771143 
    AA380967 BM770979 CF128086 F27287 CB135332 CD642508 BE385779 BG180775 
    BE901220 AA192385 BM464756 AA365777 BP364338 BE777964 CD251848 BP355336 
    BE901924 BP337493 BG686714 BX429367 BF036446 BC017233 AA666249 BU509561 
    AA370165 BI869557 BE741489 BF797661 BF026863 BM721168 AI924799 BP363936 
    BG875921 CF139933 BQ689485 BG290965 BU521703 BP353968 BP355454 BE889602 
    BG615754 BQ232433 AI816457 BM845769 BX408319 AA357506 BM787724 BP364267 
    BU674727 CA441408 BP364859 AI468968 BM973982 BE709875 CB216341 BE540478 
    BM976663 BP349633 BM090880 AW339156 CB120653 BU958911 BP362353 N41314 
    BQ026788 BM835449 CF785936 AW291073 BM982326 BP364693 CK000235 BE790647 
    F04690 BI559881 AW769840 BP372802 BP366309 CA443465 BQ947778 BE264128 
    AW084778 BU158742 BG565941 BU542097 BP365906 BP383256 T49737 BU556882 
    BI089071 AI032857 BP363383 BG675007 BP354149 BP354772 AI016543 BX487201 
    BG031692 BI597709 AA306270 BG179584 BG163650 BQ071421 BP382651 BP364565 
    BM504273 BX367632 BU681406 BG616242 AW149862 BI816693 BX423094 BU595042 
    BX443003 AL044324 BP355554 BG545698 AA708498 BP348787 BM793683 BQ718134 
    AW675456 BX428767 BM770961 BX408659 BE269673 BX424913 AW615324 BP340789 
    CD356101 BU942308 BF103833 AI065000 BP347975 AA315439 BE542334 BG748114 
    BG574690 BM749614 AW571632 BM829499 BG393123 BX450050 BX428746 BQ006474 
    BQ008757 AA703772 T08862 AI090489 AW403943 W76644 BI546603 BM762068 
    CD512397 BP343950 BX641634 CF139473 BI596578 BX429937 BQ681826 BM796037 
    BU538137 BM472864 BP355246 AA132704 BM704177 BP363718 BG479257 AW157708 
    BQ343701 BM046400 BM839422 CF126448 BU177028 BU188596 BX410473 BX449761 
    CB136178 BP353723 BP366094 BG204984 BQ639029 BX449987 BM745923 BP355353 
    BG207603 CB148676 BE728427 BG480206 BQ694825 BP360072 CB160280 BM471694 
    BM794250 BE888053 BE887364 AW150199 BG717081 BP356847 BM750399 AK129557 
    BG944658 AA552549 AI979099 BM749151 BP361425 BX387983 CA417837 BE744684 
    CB136126 BF205554 BX326017 BQ314685 BE280814 BM679591 BG427434 BE265118 
    AW023404 BE315127 AI571459 BQ276361 BU538672 BP356175 BP353109 AA383729 
    BM832464 BU174037 BG541817 N47762 BF026023 BM909923 BG491269 BQ351893 
    BP363598 BE793037 AA644346 BE391279 BG186462 BP355575 AA306976 BM353379 
    BQ683437 BQ340541 BP375807 AA778423 BE315545 AA312400 CB133779 F09961 
    BE780376 BM090832 BP354278 CD300733 BQ214952 CA395053 CB124533 BP364194 
    BX408060 BU856916 BM755674 BM462689 BG198125 CB123974 BQ717290 BE561569 
    BM835481 BQ879999 AW272310 AA308606 AI000357 BG472704 BF221833 BG024230 
    CA439337 AI272184 BP364521 BP381918 BE744252 AA099074 BE741417 BQ775638 
    BF035067 AA356486 CA395866 CB853790 BQ682726 AA320302 BG403704 BX953123 
    BP354481 AI539592 AW264114 CB134075 BP356281 CD105385 BG291970 BQ230557 
    BF036642 BP364718 BP357373 CB139283 BP363589 BU166480 BI597025 AA120908 
    BQ071906 AW571560 BU685827 AA191282 BP354860 BX452882 AU123157 BU676981 
    BP360936 BQ440415 BM504491 BX450399 BF038655 BG290828 BP356890 BM836527 
    BG723783 BG756323 BP353937 AI089281 BM834226 BX450544 BU682388 BP354730 
    BI548244 BG289676 BF438506 BG574789 CA418368 BP355935 BE266356 BG185911 
    BX449730 BG714859 BM005757 BP361930 BG745446 BQ638414 AA360913 AI207707 
    BU689173 BM090654 AA307671 CK002723 BG388282 BG612887 BE276457 BE891315 
    BP353400 BE538745 BP354204 AA630652 BX400070 BE536707 BG473460 BX408742 
    BE253510 AA307057 BE888254 BF025820 BQ231715 CD244499 BF975201 BU194091 
    BE903080 CF146559 BG292357 AI094164 BX494275 BG827229 BF026049 BP364697 
    BP380620 BQ774768 BE272063 BP360900 CB112801 BE878706 BQ056805 BM771234 
    BP375297 BM796404 AI803387 AW245186 BP341192 BM556629 BG774144 CB136142 
    AA706279 BP356124 CB124187 BM999305 BM014625 BM787583 AA482327 AA216434 
    AW902632 BQ222889 BG282141 BG547132 AJ714902 BP349361 BU157539 BQ722147 
    AA364389 CF780809 BX439717 BQ775921 CA420816 BI551485 AI983238 AA223171 
    BU932356 BP359543 BE780700 BE894631 BP354624 BE780815 BE294066 AV725438 
    BU629329 CD356450 BP354074 BE876023 AI092228 AA857523 BP357051 BM835671 
    BG397902 BE741698 AA129370 BP355462 AA333236 BE048702 BX416309 BM754083 
    BG705954 BU171768 AI886733 BX450190 BE256139 BI562093 BG214461 CD557527 
    BU950480 AJ714083 F03806 BP358136 BX438139 BU195567 BP363565 BQ217096 
    CF126651 BI224350 BP364605 BP339770 BI438939 BG532378 AI890897 BG191034 
    BG477845 CD643121 AA374231 BG681060 AA704189 BQ351610 BP364725 BM811462 
    BQ048993 BQ437648 BP380622 BU543868 AJ713652 BF314704 BE298818 CB409511 
    BG761047 AA683206 BG326918 AI954471 BP359706 BG615180 AA383060 BX445552 
    BM827660 BG035664 CA418209 BQ278328 AI742363 AA351203 BQ230351 BX646864 
    BG341494 BG184335 BG480678 BP355010 BM017471 AU279662 BG614604 BP365326 
    BE272291 BQ348772 AA703828 BQ935401 BG029407 CF594107 CD300374 BE893889 
    BM835710 BI600585 AA120909 BF038555 BE744275 AA371200 BU145858 BG027434 
    BG696742 CB128594 F29908 BF975974 AW149906 AA306893 BE899252 AI581146 
    BX420477 CA417560 BE727316 BP383463 BE275314 AA364614 CB152885 AI799397 
    BM765395 BE784768 BX429886 BE889051 BF309384 CD110324 BG502440 BE267266 
    BU155756 AI922501 BU729713 R29731 CF995684 W73056 BP349252 CB158569 
    AU123790 BP365535 AA679491 BP354778 BM827838 AA320835 AI090696 AW902549 
    BP361190 CB135370 BF037018 BG291922 BP357213 AI808104 BU163401 CB114936 
    BP350266 BE734269 BU171509 BU542070 BI159911 BF674008 BQ685997 BQ438105 
    BU169266 AI580322 BG284836 BE386388 BQ951837 AA334804 CA424392 AA626817 
    AI174952 BG255545 BP374826 BM833525 AI201790 BE742334 BU189393 BP353116 
    CB962103 AI685234 BM470436 BP348628 CA418135 BG325276 BP364031 BU160618 
    AA375987 BG193239 BP364310 BM799253 BQ688846 BP365267 BM740981 AW572409 
    BP357711 BU951773 CB988207 AA351665 BM787451 BX451852 AA361608 BP364843 
    BX440283 BX462405 AA305037 BI547467 BM759085 BG778350 BP357862 BE707294 
    BQ439853 AW780228 BQ360171 BI869349 BG339697 BX347362 BM006074 BQ694576 
    AI925796 BM009912 AJ713393 BF025892 BF026846 BX460056 BP365377 BE886493 
    BQ432799 BP356345 BP337701 BQ310971 AA132815 BM834412 BM743378 BM835656 
    BP363463 BM842950 BF684109 BE792969 AU129848 BE744566 BQ642828 BM046393 
    BX429016 BM460711 BU600536 BM750040 AA513807 AK056446 BX500541 BX408485 
    BM090605 BX438704 BP355969 BE897016 N34251 BM845485 BU958743 BM787476 
    BX429873 BX408175 BP365671 BU185532 CB122800 BQ268388 BE894580 BX406883 
    BM770755 BP344055 BE780007 CB409232 BE266239 CA420189 BG828134 BI857860 
    BQ774002 BQ222901 BM771431 BG776818 BU687472 BP380713 AA076020 BQ646742 
    BP371119 BU177948 AW168775 BP361901 BU553466 BP346936 BM827598 BP375817 
    BP363377 BE501656 BM853647 CB961585 BG339431 BP347759 AI338430 BQ706145 
    BX449814 BP354339 AV652506 BF686119 BC007989 BF972290 BQ924340 AA419412 
    BP364434 BU508282 BM014389 BX450684 BM511980 BQ424753 R52323 BX478367 
    BG260362 BE893586 BX419794 BX429290 BP354469 BP354532 BQ045432 BG434834 
    BM787879 BP354681 AA599238 W56527 AI687004 AA725103 BX429017 BM751997 
    BM817439 BG740397 CD102005 BP363216 AI371186 BG424451 BI561300 BQ676204 
    CK024012 CB140669 BM749102 AI347442 BM835155 BQ351934 BM046384 BF037183 
    BU594684 BP365857 AA229107 CB988109 BM836062 AI816296 BE879242 BE786120 
    BP351305 BM770680 BM564713 BP363934 AV707039 BQ677380 BE386278 BP349380 
    BM353224 BG699496 BG419926 BP364069 BU615165 BG547687 BF980555 BF698935 
    BQ351892 BX446993 BX408660 AA587981 BQ684434 CB156030 BX438531 BF174989 
    BP355109 BP368276 BX408795 BE744444 BQ679117 BE868465 AA402284 BQ420439 
    BE393310 BG395366 BP364078 BQ638645 BM469186 BI089367 BG178464 BU933549 
    BP349807 BE891640 BM829007 N50947 BM827702 BG771608 BF688223 BG620390 
    BX407458 BM745285 BX434560 BG620186 AI818880 BU838705 BG761594 BM751858 
    CA417967 BI560266 BE793288 BI088544 AW503031 BQ064487 BI258801 AA133890 
    BU678266 BQ878293 BP365335 BE716035 BG699612 BM790221 AI089273 BQ776250 
    BU158444 AA679253 AA629891 BQ227711 CB961584 BX425456 AI380044 BP361334 
    BP359102 BP354441 F36751 AA991804 BP337734 BU155644 BP359120 H94609 
    BM470403 BG569320 BI117290 CB123132 AA669137 BE621978 BP350509 BE268085 
    BP377964 AA323607 BE901519 BF337005 BE889647 BM452892 BU781967 BX495613 
    BE743661 CB164057 BP349602 BX496316 BU164481 BI596554 BX413706 AL046504 
    BX422652 BQ897317 BG284408 BX387984 BF973561 BE410080 CA418071 AA310601 
    BM828369 BE408286 BI464443 BX429865 BG566910 BG528922 BU542725 CA440452 
    BG254833 BP349360 BE268044 AI311913 BX459988 BI460801 AV714108 BM794909 
    CA445435 AA383454 BF576079 BE302151 BE887720 AI394675 BM751684 BQ639161 
    BX429293 BU941176 BG389458 BE536491 BM835757 AI096990 BG196262 BM817677 
    AA548565 BM552623 AA371492 CB989811 BM479916 BG104825 BG708576 BQ213099 
    BE613850 AI174842 BF208054 BF315264 BG336589 BG677196 BM832731 BX408889 
    BG287252 BU933219 BU193760 BG421722 AI377472 BP363387 BM822192 BX408017 
    CB851315 BQ438205 BP349364 BI603518 BP361295 BG701752 AI110792 AU122886 
    BI850721 BU674027 BG286966 BP346192 BM759527 AI005344 BE892481 AV688833 
    BU789208 BG418985 BP365449 BG289859 AL045961 BX434332 BE622572 BQ351725 
    BU944640 BG720871 BI870095 BF128762 BM828617 BP355412 BP350738 CA423232 
    NM_005348 BG200354 BE794630 BQ350320 AI926828 BG756223 BM453635 CA415013 
    BI464350 BG030941 BP357405 AL038129 BP365071 BQ319043 BM839633 BP379057 
    BU189219 BI117278 BI093337 BM834150 BP339584 BX407811 CB961248 BM793259 
    AI401635 BM460113 AI352264 BM006640 BE797111 BE895466 AA316587 BQ636100 
    BX506465 BM834363 BP360795 BI462467 AW071112 BX485754 BP355677 CB112960 
    BP372818 BM450631 BE898524 BM310052 BU182116 CB409432 BM680263 BM471509 
    BM835423 BP357449 BG200356 AV705885 BP355906 BP346903 CF144702 CB115080 
    CD244989 AA984694 BG420237 BU860914 BM828361 CD300070 BQ653966 AI859281 
    BP360473 BX408321 BG699179 BX495971 CF455720 CA417821 BP354974 BP349769 
    BP353455 BX411091 BQ946092 BU631792 BG574952 BF686109 BQ441067 AA300804 
    AF074699 AA699607 BP356437 BU194003 BP366283 CB144577 BM751888 BQ278199 
    BP364379 BU167557 AA644668 BF751036 BM955671 AI003330 AV756792 CK003121 
    BE795628 BQ351616 BQ953366 AW673676 AA303631 BG255991 AA171998 CA412078 
    BX462356 BG677512 AL121253 AA630369 AU126227 BG288987 AW514752 BU626011 
    BE740859 CB143565 AI184461 F22795 BE742826 AA565553 BQ775147 BX450651 
    BQ057059 BP353246 BQ323764 BQ351705 W56591 BG428808 AA370504 BQ231349 
    CD105178 BE221359 AA773161 BP336361 BI860660 CD512377 BF983066 AA991208 
    BP364607 BM976034 BM750463 BP363744 BX421977 AA666061 CA440454 BQ223489 
    BM475063 BQ938167 CD105800 BX470282 BU179638 AA357454 BP366204 BG255340 
    BI117018 AA365619 BP348949 BM835441 BP355310 AV649676 BX403839 BP349643 
    BM835712 BU171689 CD557018 AA370456 BM833047 AA985112 AI954116 BP365312 
    X15183 BI115963 BM787749 AA602299 BM745318 BE278498 BG184330 AW057643 
    AA578660 AA381564 BM984767 BG200735 CD359890 AI969532 BM835843 F27516 
    BU176685 AL705103 BM041939 BE799410 BF974362 BP357675 BE877044 BX450262 
    BQ351751 BG478839 BQ877018 AW081635 BU521376 BG392631 AA774999 BM798416 
    BP345107 CB134593 BQ694564 BG290197 BP365230 BU686526 BE735758 BM459146 
    BP347238 BQ020503 CB152257 BG756408 BG403752 BE177723 BE881191 BM787553 
    BP341144 AA356627 BE785041 CB148113 BM794262 AW902548 BM558627 AA026444 
    BM834939 CA422230 BP352291 AA214083 BG530549 BQ231785 CA406303 BE730766 
    BE892885 AI735365 BE384187 AA985095 BM789194 BX404657 BM015978 BG289647 
    BE382772 BM016093 BE780823 BG025312 AA320116 BQ685091 BM462658 AA921967 
    BG034614 BQ645817 BM976869 AA372480 BQ360396 BQ317558 BE799905 AA312386 
    BG189060 AA353752 BQ351666 AA564649 BE787672 BQ378484 BE887391 BF688608 
    CN479227 H85198 BU147213 BE614457 BX429074 BM424217 BG528988 BE299233 
    AA223172 AA099565 AA013363 BX450468 BX455227 AA356106 AA244154 CD642932 
    BM146435 BI551637 CF139787 AW388972 BG037050 BX450871 AA112734 BM689490 
    BU165201 BE302661 BG187992 AA192634 AW663290 BM042528 BG200355 W00382 
    R54487 BX408222 BG185910 BG197250 BX347352 AA214188 AA206255 BE966696 
    BE967085 BF129778 AI879407 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         

    ExUns: 16a · 16b

    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    HSP90AA1 Expression
    About this image

    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     Liver (Hepatobiliary System)
             Liver Lobule
     Tooth (Integumentary System)
             Dental Enamel
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525600
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.12(n)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.01(n)
      423463  NM_001109785.1  NP_001103255.1 
    (Anolis carolinensis)
    Reptilia HSP90AA16
    heat shock protein 90kDa alpha (cytosolic), class ...
    1 ↔ 1
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsp90aa1.11 heat shock protein 90kDa alpha (cytosolic), class A more 79.83(n)
      549036  NM_001016282.2  NP_001016282.1 
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    1 → many
    (Caenorhabditis elegans)
    Secernentea daf-216
    Protein DAF-21 (daf-21) mRNA, complete cds
    1 → many
    V(14684918-14688543) WBGene00000915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4 Cytoplasmic chaperone of the Hsp90 family, redundant more   --   13(632355-634472) 855224  NP_013911.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP81-21 HSP81-2 67.96(n)
      835701  NM_124985.4  NP_200414.1 
    (Oryza sativa)
    Liliopsida Os09g04821001 Os09g0482100 66.43(n)
      4347402  NM_001070035.1  NP_001063500.1 

    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for HSP90AA1 gene
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    Find genes that share paralogs with HSP90AA1           About GenesLikeMe

    Selected Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSP90AA1 (see all 1394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 14 posSequence#AA
    C--82751808(+) TTTTT-/TT/TTT
    1 -- int11NA 2
    C--83556227(+) TTTTT-/TTT/TT
    1 -- int11NA 2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSP90AA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670326CNV Deletion23128226
    nsv1428CNV Insertion18451855
    esv25342CNV Loss19812545
    nsv832879CNV Loss17160897
    dgv25n68CNV Loss17160897

    Human Gene Mutation Database (HGMD): HSP90AA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90AA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 140571    OMIM disorders: --

    5 diseases for HSP90AA1:    
    About MalaCards
    hand-foot-genital syndrome    neuronal intranuclear inclusion disease    lobular neoplasia    primary hyperoxaluria
    gastrointestinal stromal tumor

    3 inferred disease relationships from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    Find genes that share disorders with HSP90AA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Genetic Association Database (GAD): HSP90AA1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 10 sources (see all 1998):
    (articles sorted by number of sources associating them with HSP90AA1)

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (Genomics 2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (Mol. Cell. Biol. 1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (J. Cell Biol. 1998)
    4. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (J. Biol. Chem. 1998)
    6. Hsp90 is regulated by a switch point in the C-terminal domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (EMBO Rep. 2009)
    7. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. (PubMed id 11274138)1, 2, 9 Forsythe H.L.... Holt S.E. (J. Biol. Chem. 2001)
    8. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A.... Lamas S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (EMBO J. 2003)
    10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    (According to HUGE)
    About This Section

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    CRISPR knockouts from OriGene)
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