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Aliases for HSP90AA1 Gene

Aliases for HSP90AA1 Gene

  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
  • HSP90A 3 4 6
  • HSPCA 3 4 6
  • HSPC1 3 4 6
  • Lipopolysaccharide-Associated Protein 2 3 4
  • Heat Shock 90kDa Protein 1, Alpha 2 3
  • Renal Carcinoma Antigen NY-REN-38 3 4
  • Heat Shock 90kD Protein 1, Alpha 2 3
  • LPS-Associated Protein 2 3 4
  • Heat Shock 86 KDa 3 4
  • HSPCAL4 3 6
  • HSP 86 3 4
  • HSP89A 3 6
  • HSP86 3 4
  • LAP-2 3 4
  • LAP2 3 6
  • Epididymis Luminal Secretory Protein 52 3
  • Heat Shock 90kD Protein 1, Alpha-Like 4 3
  • Heat Shock 90kD Protein, Alpha-Like 4 3
  • Heat Shock Protein HSP 90-Alpha 3
  • HSPCAL1 3
  • HSP90N 3
  • Hsp89 3
  • Hsp90 3
  • EL52 3
  • HSPN 3

External Ids for HSP90AA1 Gene

Previous HGNC Symbols for HSP90AA1 Gene

  • HSPC1
  • HSPCA

Previous GeneCards Identifiers for HSP90AA1 Gene

  • GC14M101619
  • GC14M102547

Summaries for HSP90AA1 Gene

Entrez Gene Summary for HSP90AA1 Gene

  • The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSP90AA1 Gene

HSP90AA1 (Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include lobular neoplasia and neuronal intranuclear inclusion disease. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot for HSP90AA1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Tocris Summary for HSP90AA1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors), transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic proteins.

Gene Wiki entry for HSP90AA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene

Genomics for HSP90AA1 Gene

Regulatory Elements for HSP90AA1 Gene

Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:

Genomic Location for HSP90AA1 Gene

Start:
102,080,738 bp from pter
End:
102,139,749 bp from pter
Size:
59,012 bases
Orientation:
Minus strand

Genomic View for HSP90AA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90AA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA1 Gene

Proteins for HSP90AA1 Gene

  • Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07900-HS90A_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha
    Protein Accession:
    P07900
    Secondary Accessions:
    • A8K500
    • B3KPJ9
    • Q2PP14
    • Q5CAQ6
    • Q5CAQ7
    • Q9BVQ5

    Protein attributes for HSP90AA1 Gene

    Size:
    732 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    • Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8. May interact with NWD1 (PubMed:24681825).

    Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene

    Alternative splice isoforms for HSP90AA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSP90AA1 Gene

Proteomics data for HSP90AA1 Gene at MOPED

Post-translational modifications for HSP90AA1 Gene

  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
  • Ubiquitination at Lys58, Lys74, Lys84, Lys112, Lys153, Lys185, Lys191, Lys209, Lys224, Lys283, Lys292, Lys294, Lys314, Lys327, Lys362, Lys407, Lys419, Lys436, Lys443, Lys446, Lys478, Lys489, Lys499, Lys513, Lys539, Lys615, and Lys632
  • Modification sites at PhosphoSitePlus

Other Protein References for HSP90AA1 Gene

Antibody Products

  • R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
  • Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)

Protein Products

  • Enzo Life Sciences proteins for HSP90AA1

No data available for DME Specific Peptides for HSP90AA1 Gene

Domains for HSP90AA1 Gene

Gene Families for HSP90AA1 Gene

HGNC:
  • HSPC :Heat shock proteins / HSPC

Suggested Antigen Peptide Sequences for HSP90AA1 Gene

Graphical View of Domain Structure for InterPro Entry

P07900

UniProtKB/Swiss-Prot:

HS90A_HUMAN :
  • P07900
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA1: view

Function for HSP90AA1 Gene

Molecular function for HSP90AA1 Gene

UniProtKB/Swiss-Prot Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Ontology (GO) - Molecular Function for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 11470816
GO:0002134 UTP binding IEA --
GO:0002135 CTP binding IEA --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 12176997
genes like me logo Genes that share ontologies with HSP90AA1: view

Phenotypes for HSP90AA1 Gene

genes like me logo Genes that share phenotypes with HSP90AA1: view

Animal Models for HSP90AA1 Gene

MGI Knock Outs for HSP90AA1:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSP90AA1 Gene

Localization for HSP90AA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90AA1 Gene COMPARTMENTS Subcellular localization image for HSP90AA1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
endoplasmic reticulum 3
nucleus 3
chloroplast 2
cytoskeleton 2
endosome 2
extracellular 2
mitochondrion 2
vacuole 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HSP90AA1: view

Pathways for HSP90AA1 Gene

genes like me logo Genes that share pathways with HSP90AA1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001764 neuron migration IEA --
GO:0003009 skeletal muscle contraction IEA --
GO:0006200 obsolete ATP catabolic process --
genes like me logo Genes that share ontologies with HSP90AA1: view

Compounds for HSP90AA1 Gene

(19) ApexBio Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG (KOS953) ansamycin antibiotic which acts as an anti-tumor agent [75747-14-7]
17-AAG Hydrochloride binds to Hsp90 and alters its function. [911710-03-7]
17-DMAG (Alvespimycin) HCl potent HSP90 inhibitor [467214-21-7]
Alvespimycin selective Hsp90 inhibitor [467214-20-6]
AT13387 non-geldanamycin HPS90 [912999-49-6]
AUY922 (NVP-AUY922) potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90 [747412-49-3]
BIIB021 oral fully synthetic Hsp90 inhibitor. [848695-25-0]
Ganetespib (STA-9090) potent small-molecule inhibitor of Hsp90 [888216-25-9]
IPI-504 (Retaspimycin hydrochloride) selective inhibitor of Hsp90 [857402-63-2]
KW-2478 novel and potent nonansamycin inhibitor of Hsp90 [819812-04-9]
MPC-3100 orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 [958025-66-6]
NVP-BEP800 binds to the NH2-terminal ATP-binding pocket of Hsp90. [847559-80-2]
PF-04929113 (SNX-5422) orally bioavailable Hsp90 inhibitor. [908115-27-5]
PU-H71 potent Hsp90 inhibitor [873436-91-0]
Radicicol potent inhibitor of Hsp90, SRC, and Cox-2 [12772-57-5]
Retaspimycin small-molecule inhibitor of HSP90 [857402-23-4]
SNX-2112 Hsp90 inhibitor [908112-43-6]
VER 155008 potent inhibitor of Hsp70 family of chaperones [1134156-31-2]
XL-888 novel and orally-bioavailable inhibitor of HSP90 [1149705-71-4]

(5) Tocris Compounds for HSP90AA1 Gene

Compound Action Cas Number
17-AAG Selective Hsp90 inhibitor [75747-14-7]
Gedunin Hsp90 inhibitor; exhibits anticancer and antimalarial activity [2753-30-2]
Geldanamycin Selective Hsp90 inhibitor [30562-34-6]
PU H71 Potent Hsp90 inhibitor [873436-91-0]
Radicicol Hsp90 inhibitor. Antifungal antibiotic [12772-57-5]

(113) Novoseek inferred chemical compound relationships for HSP90AA1 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 97.9 261
17-(allylamino)-17-demethoxygeldanamycin 96.8 161
radicicol 95.8 133
17-amino-17-demethoxygeldanamycin 85.5 3
17-dmag 83.4 6
genes like me logo Genes that share compounds with HSP90AA1: view

Transcripts for HSP90AA1 Gene

Unigene Clusters for HSP90AA1 Gene

Heat shock protein 90kDa alpha (cytosolic), class A member 1:
Representative Sequences:

CRISPR Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HSP90AA1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HSP90AA1 Gene

GeneLoc Exon Structure for
HSP90AA1
ECgene alternative splicing isoforms for
HSP90AA1

Expression for HSP90AA1 Gene

mRNA expression in normal human tissues for HSP90AA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90AA1 Gene

SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene Hs.525600

genes like me logo Genes that share expressions with HSP90AA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90AA1 Gene

Orthologs for HSP90AA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSP90AA1 35
  • 99.18 (n)
  • 99.45 (a)
HSP90AA1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSP90AA1 35
  • 88.62 (n)
  • 98.36 (a)
HSP90AA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90AA1 35
  • 87.47 (n)
  • 97.77 (a)
HSP90AA1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90aa1 35
  • 90.12 (n)
  • 98.77 (a)
Hsp90aa1 16
Hsp90aa1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSP90AA1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90AA1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90aa1 35
  • 90.89 (n)
  • 98.91 (a)
chicken
(Gallus gallus)
Aves HSP90AA1 35
  • 82.01 (n)
  • 95.6 (a)
HSP90AA1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90AA1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90aa1.1 35
  • 79.83 (n)
  • 93.26 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
hsp90aa1.2 35
  • 77.44 (n)
  • 90.96 (a)
hsp90aa1.2 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hsp83 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-21 36
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 38
HSP82 36
  • 61 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP81-2 35
  • 67.96 (n)
  • 71.47 (a)
rice
(Oryza sativa)
Liliopsida Os09g0482100 35
  • 66.43 (n)
  • 71.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3846 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11103 36
  • 79 (a)
OneToMany
Species with no ortholog for HSP90AA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSP90AA1 Gene

ENSEMBL:
Gene Tree for HSP90AA1 (if available)
TreeFam:
Gene Tree for HSP90AA1 (if available)

Paralogs for HSP90AA1 Gene

Paralogs for HSP90AA1 Gene

genes like me logo Genes that share paralogs with HSP90AA1: view

Variants for HSP90AA1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4947 -- 102,084,466(-) AACAA(C/T)ATCAA reference, synonymous-codon
rs745313 -- 102,116,780(+) caatg(A/G)ggctg intron-variant
rs1058078 -- 102,081,311(-) CTTTT(C/T)GAACT utr-variant-3-prime
rs1059623 -- 102,080,881(-) GCACA(C/T)GTAGG utr-variant-3-prime
rs1059629 -- 102,080,768(-) CTGTG(C/T)TAAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HSP90AA1 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV Loss 17160897
nsv832879 CNV Loss 17160897
nsv1428 CNV Insertion 18451855
esv2670326 CNV Deletion 23128226
esv25342 CNV Loss 19812545

Relevant External Links for HSP90AA1 Gene

HapMap Linkage Disequilibrium report
HSP90AA1
Human Gene Mutation Database (HGMD)
HSP90AA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Disorders for HSP90AA1 Gene

(3) University of Copenhagen DISEASES for HSP90AA1 Gene

(91) Novoseek inferred disease relationships for HSP90AA1 Gene

Disease -log(P) Hits PubMed IDs
shock 92.7 181
cancer 62.7 242
tumors 53.5 178
breast cancer 42.1 63
neurodegenerative diseases 39.5 7

Relevant External Links for HSP90AA1

Genetic Association Database (GAD)
HSP90AA1
Human Genome Epidemiology (HuGE) Navigator
HSP90AA1
genes like me logo Genes that share disorders with HSP90AA1: view

No data available for UniProtKB/Swiss-Prot for HSP90AA1 Gene

Publications for HSP90AA1 Gene

  1. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PMID: 9660753) Young J.C. … Hartl F.U. (J. Biol. Chem. 1998) 3 4 23
  2. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PMID: 9817749) Obermann W.M. … Hartl F.U. (J. Cell Biol. 1998) 3 4 23
  3. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PMID: 9195923) Silverstein A.M. … Pratt W.B. (J. Biol. Chem. 1997) 3 4 23
  4. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PMID: 12853476) Brychzy A. … Obermann W.M. (EMBO J. 2003) 3 4 23
  5. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. (PMID: 15383005) Zeke T. … Cohen P.T. (Biochem. J. 2005) 3 4 23

Products for HSP90AA1 Gene

Sources for HSP90AA1 Gene

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