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HSP90AA1 Gene

protein-coding   GIFtS: 70
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
  See HSP90AA1-related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifier: GC14M101619

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene:
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and neuronal intranuclear inclusion disease. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search Chromatin IP Primers for HSP90AA1

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

102,547,075 bp from pter      End:
102,606,086 bp from pter
59,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1,
HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with
AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for
correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts
with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding
motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
Selected PDB 3D structures from and Proteopedia for HSP90AA1 (see all 166):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • Ubiquitination2 at Lys58, Lys74, Lys84, Lys112, Lys153, Lys185, Lys191, Lys209, Lys224, Lys283,
                                 Lys292, Lys294, Lys314, Lys327, Lys362, Lys407, Lys419, Lys436, Lys443, Lys446 (see all 27)
  • Modification sites at PhosphoSitePlus

  • See HSP90AA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
    Reactome Protein details: P07900

    HSP90AA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HSP90AA1 (HSP90 alpha)
    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins for HSP90AA1
    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1
    OriGene Custom Protein Services for HSP90AA1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp.

    Search eBioscience for Proteins for HSP90AA1 

    antibodies-online proteins for HSP90AA1 (11 products) 

    antibodies-online peptides for HSP90AA1

    GeneTex Proteins for HSP90AA1:  
                        Heat Shock Protein 90 recombinant protein (GTX65117)

    HSP90AA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies for HSP90AA1
    OriGene Custom Antibody Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 (P08238, P07900)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HSP90AA1
    antibodies-online antibodies for HSP90AA1 (168 products) 

    GeneTex Antibodies for HSP90AA1:  
                        HSP90AA1 Antibodies

    HSP90AA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90AA1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for HSP90AA1 (HSP90 alpha)
    GenScript Custom Assay Services for HSP90AA1
    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSP90AA1 
    antibodies-online kits for HSP90AA1 (29 products) 

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region

    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family

    Find genes that share domains with HSP90AA1           About GenesLikeMe

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding ----
    GO:0002135CTP binding ----
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI12526792
    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with HSP90AA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       genOway: Develop your customized and physiologically relevant rodent model for HSP90AA1

        Taconic Biosicences: Generate A Custom CRISPR Mouse Model For Your Study 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for HSP90AA1

    miRTarBase miRNAs that target HSP90AA1:
    hsa-mir-25-3p (MIRT050304), hsa-mir-30c-5p (MIRT047953), hsa-mir-30e-5p (MIRT044155), hsa-mir-186-5p (MIRT045178), hsa-mir-183-5p (MIRT047124), hsa-mir-421 (MIRT039416), hsa-mir-501-5p (MIRT041140), hsa-mir-378a-3p (MIRT043944), hsa-mir-3943 (MIRT052896), hsa-let-7b-5p (MIRT052238), hsa-mir-324-3p (MIRT042829), hsa-mir-425-5p (MIRT039331), hsa-mir-484 (MIRT041642), hsa-mir-204-5p (MIRT047015), hsa-mir-222-3p (MIRT046648), hsa-mir-1226-3p (MIRT036428), hsa-mir-16-5p (MIRT031959), hsa-mir-375 (MIRT020063), hsa-mir-760 (MIRT036729), hsa-mir-185-5p (MIRT045325), hsa-mir-17-5p (MIRT050979), hsa-mir-10a-5p (MIRT047507)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1

    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for HSP90AA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA1 
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    Subcellular locations from UniProtKB/Swiss-Prot
    HS90A_HUMAN, P07900: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    plasma membrane4
    endoplasmic reticulum3
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section

    SuperPaths for HSP90AA1 About   (see all 58)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    3Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82
    vRNP Assembly0.00
    4Metabolism of nitric oxide
    eNOS activation0.00
    eNOS activation and regulation0.00
    Metabolism of nitric oxide
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.00
    5Signaling by FGFR
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR in Cancer0.82

    Find genes that share SuperPaths with HSP90AA1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    Selected BioSystems Pathways for HSP90AA1 (see all 20)
        NOD pathway
    EBV LMP1 signaling
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway

    Selected Reactome Pathways for HSP90AA1 (see all 15)
        vRNP Assembly
    HSF1-dependent transactivation
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Scavenging by Class F Receptors
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat


        GeneGlobe Interaction Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration ----
    GO:0003009skeletal muscle contraction ----
    GO:0006200ATP catabolic process IDA15937123

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AA1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    Selected DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

    Find genes that share compounds with HSP90AA1           About GenesLikeMe

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1
    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    Selected DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    Selected AceView cDNA sequences (see all 2627):

    BP354234 BM839745 BG393826 BQ685380 BX438647 BP357786 CR623660 CD358934 
    BM833745 BU581404 BM771323 BM770685 BP429471 BM771415 BM745750 BM792103 
    BM557327 BP363023 BM770054 BP365062 BU145598 BM818131 AI015385 BP363421 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         

    ExUns: 16a · 16b

    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    HSP90AA1 Expression
    About this image

    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     Liver (Hepatobiliary System)
             Liver Lobule
     Tooth (Integumentary System)
             Dental Enamel
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525600
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.12(n)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.01(n)
      423463  NM_001109785.1  NP_001103255.1 
    (Anolis carolinensis)
    Reptilia HSP90AA16
    heat shock protein 90kDa alpha (cytosolic), class ...
    1 ↔ 1
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsp90aa1.11 heat shock protein 90kDa alpha (cytosolic), class A more 79.83(n)
      549036  NM_001016282.2  NP_001016282.1 
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    1 → many
    (Caenorhabditis elegans)
    Secernentea daf-216
    Protein DAF-21 (daf-21) mRNA, complete cds
    1 → many
    V(14684918-14688543) WBGene00000915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4 Cytoplasmic chaperone of the Hsp90 family, redundant more   --   13(632355-634472) 855224  NP_013911.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP81-21 HSP81-2 67.96(n)
      835701  NM_124985.4  NP_200414.1 
    (Oryza sativa)
    Liliopsida Os09g04821001 Os09g0482100 66.43(n)
      4347402  NM_001070035.1  NP_001063500.1 

    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for HSP90AA1 gene
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    Find genes that share paralogs with HSP90AA1           About GenesLikeMe

    Selected Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    Selected SNPs for HSP90AA1 (see all 1394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 14 posSequence#AA
    C--82751808(+) TTTTT-/TT/TTT
    1 -- int11NA 2
    C--83556227(+) TTTTT-/TTT/TT
    1 -- int11NA 2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSP90AA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670326CNV Deletion23128226
    nsv1428CNV Insertion18451855
    esv25342CNV Loss19812545
    nsv832879CNV Loss17160897
    dgv25n68CNV Loss17160897

    Human Gene Mutation Database (HGMD): HSP90AA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90AA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 140571    OMIM disorders: --

    5 diseases for HSP90AA1:    
    About MalaCards
    hand-foot-genital syndrome    neuronal intranuclear inclusion disease    lobular neoplasia    primary hyperoxaluria
    gastrointestinal stromal tumor

    3 inferred disease relationships from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    Find genes that share disorders with HSP90AA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Genetic Association Database (GAD): HSP90AA1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSP90AA1 gene, integrated from 10 sources (see all 1998) (see top 10):
    (articles sorted by number of sources associating them with HSP90AA1)

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (Genomics 2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (Mol. Cell. Biol. 1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (J. Cell Biol. 1998)
    4. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (J. Biol. Chem. 1998)
    6. Hsp90 is regulated by a switch point in the C-terminal domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (EMBO Rep. 2009)
    7. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. (PubMed id 11274138)1, 2, 9 Forsythe H.L.... Holt S.E. (J. Biol. Chem. 2001)
    8. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A.... Lamas S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (EMBO J. 2003)
    10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)
    11. Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. (PubMed id 15383005)1, 2, 9 Zeke T....Cohen P.T. (Biochem. J. 2005)
    12. Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2, 9 Zhang M....Pearl L.H. (Mol. Cell 2005)
    13. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. (PubMed id 9195923)1, 2, 9 Silverstein A.M....Pratt W.B. (J. Biol. Chem. 1997)
    14. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    15. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    16. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    17. Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. (PubMed id 16531226)1, 2 Cliff M.J....Williams M.A. (Structure 2006)
    18. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    19. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. (PubMed id 17028174)1, 2 Baba M.... Zbar B. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    20. Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)1, 2 Beranova-Giorgianni S.... Giorgianni F. (Pituitary 2006)
    21. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    22. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    23. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    24. SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells. (PubMed id 15235609)1, 2 Hamamoto R.... Nakamura Y. (Nat. Cell Biol. 2004)
    25. Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone. (PubMed id 12604615)1, 2 Lotz G.P.... Obermann W.M.J. (J. Biol. Chem. 2003)
    26. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. (PubMed id 11583998)1, 2 Guo Y.... Voellmy R. (J. Biol. Chem. 2001)
    27. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    28. Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent. (PubMed id 9108479)1, 2 Stebbins C.E....Pavletich N.P. (Cell 1997)
    29. Mechanism of dimer formation of the 90-kDa heat-shock protein. (PubMed id 7588731)1, 2 Nemoto T.... Yokoyama K. (Eur. J. Biochem. 1995)
    30. The carboxy-terminal region of mammalian HSP90 is required for its dimerization and function in vivo. (PubMed id 8289821)1, 2 Minami Y.... Yahara I. (Mol. Cell. Biol. 1994)
    31. Molecular cloning of cDNA encoding a human heat-shock protein whose expression is induced by adenovirus type 12 E1A in HeLa cells. (PubMed id 1368637)1, 2 Yamazaki M.... Soeda E. (Agric. Biol. Chem. 1990)
    32. Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II. (PubMed id 2492519)1, 2 Lees-Miller S.P. and Anderson C.W. (J. Biol. Chem. 1989)
    33. Cloning and analysis of a human 86-kDa heat-shock-protein-encoding gene. (PubMed id 2591742)1, 2 Walter T.... Benecke B.J.J. (Gene 1989)
    34. Nucleotide sequence of a full-length cDNA for 90 kDa heat-shock protein from human peripheral blood lymphocytes. (PubMed id 2780322)1, 2 Soeda E.... Imai T. (Nucleic Acids Res. 1989)
    35. The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues. (PubMed id 2507541)1, 2 Lees-Miller S.P. and Anderson C.W. (J. Biol. Chem. 1989)
    36. Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly identified tumour-specific transplantation antigens. (PubMed id 2469626)1, 2 Hoffmann T. and Hovemann B. (Gene 1988)
    37. Structural studies on the co-chaperone Hop and its complexes with Hsp90. (PubMed id 18485364)1, 9 Onuoha S.C....Jackson S.E. (J. Mol. Biol. 2008)
    38. Identification of residues on Hsp70 and Hsp90 ubiquitinated by the cochaperone CHIP. (PubMed id 19913553)1, 9 Kundrat L. and Regan L. (J. Mol. Biol. 2010)
    39. Localization of sites of interaction between p23 and Hsp90 in solution. (PubMed id 16565516)1, 9 Martinez-Yamout M.A....Dyson H.J. (J. Biol. Chem. 2006)
    40. Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. (PubMed id 11779851)1, 9 Fujita N....Tsuruo T. (J. Biol. Chem. 2002)
    41. A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages. (PubMed id 19758187)1, 9 De Paepe B....De Bleecker J.L. (Ann. N. Y. Acad. Sci. 2009)
    42. Molecular characterization of hsp90 isoforms in colorectal cancer cells and its association with tumour progression. (PubMed id 18497978)1, 9 Milicevic Z....Krivokapic Z. (Int. J. Oncol. 2008)
    43. Heat shock protein90 in lobular neoplasia of the breast. (PubMed id 18957107)1, 9 Zagouri F....Zografos G.C. (BMC Cancer 2008)
    44. ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. (PubMed id 15972449)1, 9 Castro J.E....Kipps T.J. (Blood 2005)
    45. HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells. (PubMed id 18591380)1, 9 Rao R....Bhalla K. (Blood 2008)
    46. Stimulation of the weak ATPase activity of human hsp90 by a client protein. (PubMed id 11812147)1, 9 McLaughlin S.H....Jackson S.E. (J. Mol. Biol. 2002)
    47. Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. (PubMed id 19682504)1, 9 Banz V.M....Stroka D. (Biochim. Biophys. Acta 2009)
    48. HSP90 as a marker of progression in melanoma. (PubMed id 18037622)1, 9 McCarthy M.M....Kluger H.M. (Ann. Oncol. 2008)
    49. Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway. (PubMed id 16741950)1, 9 Pines A....Tell G. (J. Cell. Physiol. 2006)
    50. Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization. (PubMed id 15319539)1, 9 Katschinski D.M....Wenger R.H. (Cell. Physiol. Biochem. 2004)
    51. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. (PubMed id 12803546)7, 9 Okada M....Kobayashi R. (Biochem. J. 2003)
    52. Interactions of p60, a mediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70. (PubMed id 8776728)1, 9 Chen S....Smith D.F. (Mol. Endocrinol. 1996)
    53. Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. (PubMed id 20159553)1, 9 Mollapour M....Neckers L. (Mol. Cell 2010)
    54. Hsp90 and a tyrosine embedded in the Hsp90 recognition loop are required for the Fer tyrosine kinase activity. (PubMed id 19159681)1, 9 Hikri E.... Nir U. (Cell. Signal. 2009)
    55. Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin. (PubMed id 19142186)1, 9 Wu X....Ekman S. (Br. J. Cancer 2009)
    56. Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. (PubMed id 17698952)1, 9 He F....Song Z.H. (Mol. Pharmacol. 2007)
    57. Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma. (PubMed id 16923571)1, 9 Duus J....Alkan S. (amp 2006)
    58. Hsp90 chaperones wild-type p53 tumor suppressor protein. (PubMed id 15358769)1, 9 Walerych D....Zylicz M. (J. Biol. Chem. 2004)
    59. Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90. (PubMed id 15062560)1, 9 Tago K....Takano K. (Mol. Cell. Endocrinol. 2004)
    60. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. (PubMed id 12176997)1, 9 Basso A.D....Rosen N. (J. Biol. Chem. 2002)
    61. Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cells. (PubMed id 17977914)1, 9 McClung J.P....Singh I.S. (Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008)
    62. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. (PubMed id 18320023)1, 9 Gallegos Ruiz M.I....Giaccone G. (PLoS ONE 2008)
    63. Delimitation of two regions in the 90-kDa heat shock protein (Hsp90) able to interact with the glucocorticosteroid receptor (GR). (PubMed id 10066374)1, 9 Jibard N....Cadepond F. (Exp. Cell Res. 1999)
    64. Folding of the glucocorticoid receptor by the reconstituted Hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. (PubMed id 9148915)1, 9 Dittmar K.D. and Pratt W.B. (J. Biol. Chem. 1997)
    65. Conserved conformational changes in the ATPase cycle of human Hsp90. (PubMed id 18400751)1, 9 Richter K....Buchner J. (J. Biol. Chem. 2008)
    66. Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. (PubMed id 15009113)1, 9 Becker B....Vogt T. (Exp. Dermatol. 2004)
    67. Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. (PubMed id 12559950)1, 9 Sato N....Matsuda T. (Biochem. Biophys. Res. Commun. 2003)
    68. Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha. (PubMed id 12446770)1, 9 Marcu M.G....Neckers L. (Mol. Cell. Biol. 2002)
    69. Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly. (PubMed id 12093808)1, 9 Kanelakis K.C....Pratt W.B. (J. Biol. Chem. 2002)
    70. Functional requirement of p23 and Hsp90 in telomerase complexes. (PubMed id 10197982)1, 9 Holt S.E....White M.A. (amp 1999)
    71. Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes. (PubMed id 20146531)1, 9 Graf C....Mayer M.P. (Biochemistry 2010)
    72. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. (PubMed id 19855434)1, 9 Chandarlapaty S....Rosen N. (Oncogene 2010)
    73. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. (PubMed id 20039095)1, 9 Giommarelli C....Zunino F. (Cell. Mol. Life Sci. 2010)
    74. 90-kDa heat shock protein inhibition abrogates the topoisomerase I poison-induced G2/M checkpoint in p53-null tumor cells by depleting Chk1 and Wee1. (PubMed id 18820127)1, 9 Tse A.N....Schwartz G.K. (Mol. Pharmacol. 2009)
    75. [Association between expressions of HSP70, HSP90 and efficacy of chemotherapy in colorectal cancer patients with unresectable liver metastasis]. (PubMed id 19598015)1, 9 Chen C.W....Tan L.X. (Zhonghua Wei Chang Wai Ke Za Zhi 2009)
    76. Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. (PubMed id 18922470)1, 9 Vaughan C.K....Pearl L.H. (Mol. Cell 2008)
    77. Heat shock protein 90 overexpression independently predicts inferior disease-free survival with differential expression of the alpha and beta isoforms in gastrointestinal stromal tumors. (PubMed id 19047110)1, 9 Li C.F....Huang H.Y. (Clin. Cancer Res. 2008)
    78. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. (PubMed id 19061638)1, 9 Southworth D.R. and Agard D.A. (Mol. Cell 2008)
    79. Basal and infection-induced levels of heat shock proteins in human aging. (PubMed id 17211576)1, 9 Njemini R....Mets T. (Biogerontology 2007)
    80. Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. (PubMed id 17466273)1, 9 Spiechowicz M....Filipek A. (Biochem. Biophys. Res. Commun. 2007)
    81. Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network. (PubMed id 17956728)1, 9 Kang B.H....Altieri D.C. (Cell 2007)
    82. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. (PubMed id 16403413)1, 9 McLaughlin S.H....Jackson S.E. (J. Mol. Biol. 2006)
    83. Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. (PubMed id 16723087)1, 9 Wu L.X....Chen Y.Z. (Acta Pharmacol. Sin. 2006)
    84. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. (PubMed id 16501598)1, 9 Niikura Y....Kitagawa K. (Oncogene 2006)
    85. Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37. (PubMed id 15850399)1, 9 Roiniotis J.... Scholz G.M. (Biochemistry 2005)
    86. Phosphorylation and hsp90 binding mediate heat shock stabilization of p53. (PubMed id 12427754)1, 9 Wang C. and Chen J. (J. Biol. Chem. 2003)
    87. Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. (PubMed id 14668798)1, 9 Nony P....Billaud M. (Oncogene 2003)
    88. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. (PubMed id 11864612)1, 9 Chen G....Goeddel D.V. (Mol. Cell 2002)
    89. A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. (PubMed id 11751878)1, 9 SAPti C....Csermely P. (J. Biol. Chem. 2002)
    90. Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. (PubMed id 11071886)1, 9 Xu W....Neckers L. (J. Biol. Chem. 2001)
    91. Dynamic activation of endothelial nitric oxide synthase by Hsp90. (PubMed id 9580552)1, 9 GarcA-a-CardeA+a G....Sessa W.C. (Nature 1998)
    92. Differential requirements of Hsp90 and DNA for the formation of estrogen receptor homodimers and heterodimers. (PubMed id 20353944)1, 9 Powell E....Xu W. (J. Biol. Chem. 2010)
    93. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. (PubMed id 19751963)1, 9 Lee J.H. and Chung I.K. (Cancer Lett. 2010)
    94. Heat shock protein 90 is important for Sp1 stability during mitosis. (PubMed id 19245816)1, 9 Wang S.A....Hung J.J. (J. Mol. Biol. 2009)
    95. A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas. (PubMed id 19966776)1, 9 Cerchietti L.C....Melnick A. (Nat. Med. 2009)
    96. Expression of heat shock protein 90 at the cell surface in human neuroblastoma cells. (PubMed id 18800240)1, 9 Cid C....Alcazar A. (amp 2009)
    97. Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase. (PubMed id 19933325)1, 9 Ehrlich E.S....Yu X.F. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    98. Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity. (PubMed id 19147678)1, 9 Nguyen N....Boulay G. (Endocrinology 2009)
    99. Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling. (PubMed id 18950863)1, 9 Shi L....Yin Z. (Mol. Immunol. 2009)
    100. Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy. (PubMed id 18635949)1, 9 Kabuta T. and Wada K. (Autophagy 2008)
    101. HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway. (PubMed id 19026643)1, 9 Liu X.Y....Cheung P.C. (FEBS Lett. 2008)
    102. Immune expression and inhibition of heat shock protein 90 in uveal melanoma. (PubMed id 18245548)1, 9 Faingold D....Burnier M.N. (Clin. Cancer Res. 2008)
    103. Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin. (PubMed id 17409432)1, 9 Maloney A....Workman P. (Cancer Res. 2007)
    104. Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90. (PubMed id 17728246)1, 9 Hinz M....Scheidereit C. (J. Biol. Chem. 2007)
    105. Hsp90 regulates the Fanconi anemia DNA damage response pathway. (PubMed id 17327415)1, 9 Oda T....Yamashita T. (Blood 2007)
    106. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. (PubMed id 17299090)1, 9 Spisek R....Dhodapkar M.V. (Blood 2007)
    107. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. (PubMed id 17975158)1, 9 Lang S.A....Stoeltzing O. (Clin. Cancer Res. 2007)
    108. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. (PubMed id 16774932)1, 9 Park K.A....Hur G.M. (Carcinogenesis 2007)
    109. HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression. (PubMed id 17915561)1, 9 Wilkerson D.C....Sarge K.D. (amp 2007)
    110. beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. (PubMed id 17502619)1, 9 Ji Y....Ferro A. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    111. Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation. (PubMed id 17563756)1, 9 Qing G....Xiao G. (Cell Res. 2007)
    112. Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell. (PubMed id 17548610)1, 9 Bae J....Munshi N.C. (J. Immunol. 2007)
    113. The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. (PubMed id 16280321)1, 9 Shang L. and Tomasi T.B. (J. Biol. Chem. 2006)
    114. Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases. (PubMed id 16611982)1, 9 Terasawa K....Minami Y. (Mol. Cell. Biol. 2006)
    115. Molecular basis for TPR domain-mediated regulation of protein phosphatase 5. (PubMed id 15577939)2, 9 Yang J....Barford D. (EMBO J. 2005)
    116. Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure. (PubMed id 15777846)1, 9 Elo M.A....Lammi M.J. (Biochim. Biophys. Acta 2005)
    117. A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. (PubMed id 15647277)1, 9 De Nardo D....Scholz G.M. (J. Biol. Chem. 2005)
    118. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. (PubMed id 16024644)1, 9 Shimamura T....Shapiro G.I. (Cancer Res. 2005)
    119. Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90. (PubMed id 15344906)1, 9 Mikolajczyk M. and Nelson M.A. (Biochem. J. 2004)
    120. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. (PubMed id 12962497)1, 9 Sumanasekera W.K....Vanden Heuvel J.P. (Biochemistry 2003)
    121. G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. (PubMed id 14557268)1, 9 Luo J. and Benovic J.L. (J. Biol. Chem. 2003)
    122. Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. (PubMed id 12775586)1, 9 Ficker E....Brown A.M. (Circ. Res. 2003)
    123. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. (PubMed id 12489981)1, 9 Boudeau J....Alessi D.R. (Biochem. J. 2003)
    124. Two distinct regions of the immunophilin-like protein XAP2 regulate dioxin receptor function and interaction with hsp90. (PubMed id 11805120)1, 9 Kazlauskas A....Pongratz I. (J. Biol. Chem. 2002)
    125. Regulation of heat shock protein 90 ATPase activity by sequences in the carboxyl terminus. (PubMed id 11751892)1, 9 Owen B.A....Toft D.O. (J. Biol. Chem. 2002)
    126. Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK(+) CD30(+) lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin. (PubMed id 11888936)1, 9 Bonvini P....Rosolen A. (Cancer Res. 2002)
    127. Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase. (PubMed id 11036079)1, 9 Shao J.... Matts R.L. (J. Biol. Chem. 2001)
    128. Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70. (PubMed id 11333259)1, 9 Gusarova V....Fisher E.A. (J. Biol. Chem. 2001)
    129. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. (PubMed id 11306472)7, 9 MA1nster P.N....Rosen N. (Cancer Res. 2001)
    130. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. (PubMed id 10786835)1, 9 Scheufler C.... Moarefi I. (Cell 2000)
    131. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90. (PubMed id 10400612)1, 9 Russell L.C....Chinkers M. (J. Biol. Chem. 1999)
    132. Characterization of the Ah receptor-associated protein, ARA9. (PubMed id 9837941)1, 9 Carver L.A....Bradfield C.A. (J. Biol. Chem. 1998)
    133. The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52. (PubMed id 9392437)1, 9 Bruner K.L.... Litwack G. (Recept. Signal Transduct. 1997)
    134. Platelet adhesion to collagen under flow causes dissociation of a phosphoprotein complex of heat-shock proteins and protein phosphatase 1. (PubMed id 9269769)1, 9 Polanowska-Grabowska R....Gear A.R. (Blood 1997)
    135. Interaction between casein kinase II and the 90-kDa stress protein, HSP90. (PubMed id 7794926)1, 9 Miyata Y. and Yahara I. (Biochemistry 1995)
    136. A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90. (PubMed id 7813446)1, 9 Aligue R....Russell P. (EMBO J. 1994)
    137. Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. (PubMed id 19996089)1, 9 Tiedemann R.E....Stewart A.K. (Blood 2010)
    138. Differential heat shock protein localization in chronic lymphocytic leukemia. (PubMed id 20007907)1, 9 Dempsey N.C....Williams J.H. (J. Leukoc. Biol. 2010)
    139. Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancers. (PubMed id 20226014)1, 9 Song C.H....Kim I.A. (Breast Cancer Res. 2010)
    140. [Correlation of HSP90 mRNA expression with migration ability of human multiple myeloma cells]. (PubMed id 20416171)1, 9 Huang L.J....Yang L.H. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    141. S100 proteins regulate the interaction of Hsp90 with cyclophilin 40 and FKBP52 through their tetratricopeptide repeats. (PubMed id 20188096)1, 9 Shimamoto S.... Kobayashi R. (FEBS Lett. 2010)
    142. HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. (PubMed id 19158084)1, 9 Kekatpure V.D....Subbaramaiah K. (J. Biol. Chem. 2009)
    143. The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo. (PubMed id 19952119)1, 9 Douglas M....Normant E. (Mol. Cancer Ther. 2009)
    144. Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer. (PubMed id 19952121)1, 9 Bao R....Qian C. (Mol. Cancer Ther. 2009)
    145. Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. (PubMed id 19805354)1, 9 Gibbs A....Alumkal J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    146. Extracellular heat shock protein 90 induces interleukin-8 in vascular smooth muscle cells. (PubMed id 19028451)1, 9 Chung S.W....Kim K. (Biochem. Biophys. Res. Commun. 2009)
    147. FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor. (PubMed id 19001379)1, 9 Jarczowski F....Edlich F. (J. Biol. Chem. 2009)
    148. Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. (PubMed id 19560753)1, 9 Fang S....Yin Z. (Cell. Immunol. 2009)
    149. Expression of Hsp90 chaperone [corrected] proteins in human tumor tissue. (PubMed id 19576239)1, 9 McDowell C.L....Obermann W.M. (Int. J. Biol. Macromol. 2009)
    150. Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle. (PubMed id 19293389)1, 9 Han G....White R.E. (J. Pharmacol. Exp. Ther. 2009)
    151. A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. (PubMed id 19740745)1, 9 Woo S.H....Park I.C. (J. Biol. Chem. 2009)
    152. Elevated expression of nuclear Hsp90 in invasive breast tumors. (PubMed id 19738418)1, 9 Diehl M.C....Holt S.E. (amp 2009)
    153. Heat shock protein 90: translation from cancer to Alzheimer's disease treatment? (PubMed id 19090995)1, 9 Luo W....Chiosis G. (BMC Neurosci 2008)
    154. Substitution of only two residues of human Hsp90alpha causes impeded dimerization of Hsp90beta. (PubMed id 18347946)1, 9 Kobayakawa T....Nemoto T.K. (amp 2008)
    155. Quercetin-induced ubiquitination and down-regulation of Her-2/neu. (PubMed id 18655187)1, 9 Jeong J.H....Lee Y.J. (J. Cell. Biochem. 2008)
    156. GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. (PubMed id 18285346)1, 9 Chadli A....Toft D.O. (J. Biol. Chem. 2008)
    157. Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. (PubMed id 18343820)1, 9 He D.Y. and Ron D. (J. Biol. Chem. 2008)
    158. Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum. (PubMed id 18988734)1, 9 Spooner R.A....Lord J.M. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    159. Significance of heat-shock protein (HSP) 90 expression in acute myeloid leukemia cells. (PubMed id 18386162)1, 9 Flandrin P....Campos L. (amp 2008)
    160. Chaperone ligand-discrimination by the TPR-domain protein Tah1. (PubMed id 18412542)1, 9 Millson S.H....Prodromou C. (Biochem. J. 2008)
    161. Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome. (PubMed id 18638579)1, 9 Zurawska A....Bieganowski P. (Biochim. Biophys. Acta 2008)
    162. L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. (PubMed id 18359116)1, 9 Moriwaki Y....Takahashi R. (Neurosci. Res. 2008)
    163. Critical regulation of TGFbeta signaling by Hsp90. (PubMed id 18591668)1, 9 Wrighton K.H....Feng X.H. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    164. Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation. (PubMed id 17178836)1, 9 Kamynina E....Manor D. (Mol. Cell. Biol. 2007)
    165. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. (PubMed id 17239458)1, 9 Jung Y....Neckers L. (Biochim. Biophys. Acta 2007)
    166. Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. (PubMed id 17324930)1, 9 Zhang L....Gallagher P.J. (J. Biol. Chem. 2007)
    167. Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR). (PubMed id 18229454)1, 9 Felts S.J....Toft D.O. (amp 2007)
    168. Co-chaperone FKBP38 promotes HERG trafficking. (PubMed id 17569659)1, 9 Walker V.E....Shrier A. (J. Biol. Chem. 2007)
    169. Cystein cathepsin and Hsp90 activities determine the balance between apoptotic and necrotic cell death pathways in caspase-compromised U937 cells. (PubMed id 17707089)1, 9 Imre G....Mihalik R. (Biochim. Biophys. Acta 2007)
    170. Heat Shock Protein 90 regulates the stability of c-Jun in HEK293 Cells. (PubMed id 17978573)1, 9 Lu C....Yin Z. (Mol. Cells 2007)
    171. Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90. (PubMed id 17699868)1, 9 Fiskus W....Bhalla K. (Clin. Cancer Res. 2007)
    172. FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. (PubMed id 16495214)1, 9 Wesche J....Olsnes S. (J. Biol. Chem. 2006)
    173. Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones. (PubMed id 16330544)1, 9 Arlander S.J....Karnitz L.M. (J. Biol. Chem. 2006)
    174. Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. (PubMed id 17024179)1, 9 Okamoto T....Matsuura Y. (EMBO J. 2006)
    175. F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes. (PubMed id 16682002)1, 9 Papathanassiu A.E....Vu H.A. (Biochem. Biophys. Res. Commun. 2006)
    176. Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. (PubMed id 16740632)1, 9 Germano S....Gaudino G. (J. Biol. Chem. 2006)
    177. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. (PubMed id 16478993)1, 9 Chadli A.... Toft D. (Mol. Cell. Biol. 2006)
    178. Mechanisms of disease: the role of heat-shock protein 90 in genitourinary malignancy. (PubMed id 17088927)1, 9 Lattouf J.B....Neckers L. (Nat Clin Pract Urol 2006)
    179. Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. (PubMed id 17083915)1, 9 Noguchi M....Okayasu R. (Biochem. Biophys. Res. Commun. 2006)
    180. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. (PubMed id 16322212)1, 9 da Rocha Dias S....Marais R. (Cancer Res. 2005)
    181. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. (PubMed id 15782121)1, 9 Zhang R....Min W. (Oncogene 2005)
    182. A yeast-based assay reveals a functional defect of the Q488H polymorphism in human Hsp90alpha. (PubMed id 16171778)1, 9 MacLean M.J....Picard D. (Biochem. Biophys. Res. Commun. 2005)
    183. Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells. (PubMed id 15526284)1, 9 Lin L.Y....Liau C.S. (J. Cell. Biochem. 2005)
    184. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. (PubMed id 15916966)1, 9 Kovacs J.J....Yao T.P. (Mol. Cell 2005)
    185. Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion. (PubMed id 15782129)1, 9 Xie Q....Vande Woude G.F. (Oncogene 2005)
    186. Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone. (PubMed id 16087666)1, 9 Murphy P.J....Pratt W.B. (J. Biol. Chem. 2005)
    187. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. (PubMed id 15937340)1, 9 Bali P....Bhalla K. (J. Biol. Chem. 2005)
    188. Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. (PubMed id 15951401)1, 9 Carbone D.L....Petersen D.R. (J. Pharmacol. Exp. Ther. 2005)
    189. IL-2 increases human telomerase reverse transcriptase activity transcriptionally and posttranslationally through phosphatidylinositol 3'-kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells. (PubMed id 15843522)1, 9 Kawauchi K....Yamada O. (J. Immunol. 2005)
    190. Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. (PubMed id 16118214)1, 9 Hung J.J....Chang W.C. (J. Biol. Chem. 2005)
    191. Direct activation of HSP90A transcription by c-Myc contributes to c-Myc-induced transformation. (PubMed id 14724288)1, 9 Teng S.C....Wu K.J. (J. Biol. Chem. 2004)
    192. Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. (PubMed id 15247219)1, 9 Le Boeuf F....Huot J. (J. Biol. Chem. 2004)
    193. Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. (PubMed id 14761955)1, 9 Lee Y.-T....Chazin W.J. (J. Biol. Chem. 2004)
    194. Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling. (PubMed id 15001580)1, 9 Zhang H....Gallo K.A. (J. Biol. Chem. 2004)
    195. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. (PubMed id 15146192)1, 9 Eustace B.K....Jay D.G. (Nat. Cell Biol. 2004)
    196. ErbB2 degradation mediated by the co-chaperone protein CHIP. (PubMed id 12574167)1, 9 Zhou P....Band H. (J. Biol. Chem. 2003)
    197. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. (PubMed id 12586360)1, 9 Haendeler J....Dimmeler S. (FEBS Lett. 2003)
    198. Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII. (PubMed id 12471035)1, 9 Lavictoire S.J....Lorimer I.A. (J. Biol. Chem. 2003)
    199. Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. (PubMed id 12538866)1, 9 Sinars C.R.... Clardy J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    200. Hsp90 inhibition depletes Chk1 and sensitizes tumor cells to replication stress. (PubMed id 14570880)1, 9 Arlander S.J....Karnitz L.M. (J. Biol. Chem. 2003)
    201. Heat-shock protein 90 complexes in resting and thrombin-activated platelets. (PubMed id 12220519)1, 9 Suttitanamongkol S....Gear A.R. (Biochem. Biophys. Res. Commun. 2002)
    202. HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor. (PubMed id 11809754)1, 9 HernA!ndez M.P....Toft D.O. (J. Biol. Chem. 2002)
    203. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. (PubMed id 11751894)1, 9 Davies T.H....SA!nchez E.R. (J. Biol. Chem. 2002)
    204. Identification of Hsp90 as a stimulatory host factor involved in influenza virus RNA synthesis. (PubMed id 12226087)1, 9 Momose F....Nagata K. (J. Biol. Chem. 2002)
    205. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. (PubMed id 11146632)1, 9 Connell P.... Patterson C. (Nat. Cell Biol. 2001)
    206. Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells. (PubMed id 11425855)1, 9 Brouet A....Feron O. (J. Biol. Chem. 2001)
    207. Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. (PubMed id 11358819)7, 9 Yang J....Hait W.N. (Cancer Res. 2001)
    208. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. (PubMed id 10919672)7, 9 Srethapakdi M....Rosen N. (Cancer Res. 2000)
    209. Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. (PubMed id 10811660)1, 9 Weaver A.J.... Toft D.O. (J. Biol. Chem. 2000)
    210. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. (PubMed id 10913161)1, 9 Kang J....Kim S. (J. Biol. Chem. 2000)
    211. Dynamic association of proteasomal machinery with the centrosome. (PubMed id 10225950)1, 9 Wigley W.C....Thomas P.J. (J. Cell Biol. 1999)
    212. Expression of hsp90 and cyclin D1 in human breast cancer. (PubMed id 10376793)1, 9 Yano M....Asano G. (Cancer Lett. 1999)
    213. Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo. (PubMed id 9880522)1, 9 Bender A.T....Osawa Y. (J. Biol. Chem. 1999)
    214. The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review. (PubMed id 9749880)1, 9 Csermely P....Nardai G. (amp 1998)
    215. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. (PubMed id 9001212)1, 9 Nair S.C.... Smith D.F. (Mol. Cell. Biol. 1997)
    216. Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor. (PubMed id 9334248)1, 9 Hecht K....WikstrAPm A.C. (J. Biol. Chem. 1997)
    217. A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor. (PubMed id 9222609)1, 9 Nair S.C....Smith D.F. (amp 1996)
    218. The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. (PubMed id 8898375)1, 9 de Castro M....Chrousos G.P. (Mol. Med. 1996)
    219. Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90. (PubMed id 8962087)1, 9 Schneider C....Hartl F.U. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    220. Use of the thiol-specific derivatizing agent N-iodoacetyl-3-[125I]iodotyrosine to demonstrate conformational differences between the unbound and hsp90-bound glucocorticoid receptor hormone binding domain. (PubMed id 8621522)1, 9 Stancato L.F....Pratt W.B. (J. Biol. Chem. 1996)
    221. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. (PubMed id 7961671)1, 9 Chen H.S. and Perdew G.H. (J. Biol. Chem. 1994)
    222. A tyrosine kinase-dependent pathway regulates ligand-dependent activation of the dioxin receptor in human keratinocytes. (PubMed id 8089152)1, 9 Gradin K....Berghard A. (J. Biol. Chem. 1994)
    223. Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system. (PubMed id 8408024)1, 9 Stancato L.F....Pratt W.B. (J. Biol. Chem. 1993)
    224. Anti-androgens and the mutated androgen receptor of LNCaP cells: differential effects on binding affinity, heat-shock protein interaction, and transcription activation. (PubMed id 1540595)1, 9 Veldscholte J....Mulder E. (Biochemistry 1992)
    225. The regulatory mechanism of a client kinase controlling its own release from Hsp90 chaperone machinery through phosphorylation. (PubMed id 24117238)1 Lu X.A....Luo Y. (Biochem. J. 2014)
    226. The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer. (PubMed id 24511009)1 Coskunpinar E....Yaylim I. (Anticancer Res. 2014)
    227. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    228. Extracellular Hsp90 mediates an NF-I_B dependent inflammatory stromal program: implications for the prostate tumor microenvironment. (PubMed id 24338924)1 Bohonowych J.E....Isaacs J.S. (Prostate 2014)
    229. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor. (PubMed id 24224465)1 Chen T....Omiecinski C.J. (Biochem. J. 2014)
    230. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. (PubMed id 23428871)1 Erazo T....Lizcano J.M. (Mol. Cell. Biol. 2013)
    231. Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation. (PubMed id 23698466)1 Chen C.Y....Yang P.C. (Cancer Res. 2013)
    232. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    233. Aldehyde dehydrogenase and HSP90 co-localize in human glioblastoma biopsy cells. (PubMed id 23201460)1 Rappa F....Kast R.E. (Biochimie 2013)
    234. High expression of heat shock protein 90 is associated with tumor aggressiveness and poor prognosis in patients with advanced gastric cancer. (PubMed id 23638161)1 Wang J....Tang H. (PLoS ONE 2013)
    235. Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites. (PubMed id 23569206)1 Eckl J.M....Richter K. (J. Biol. Chem. 2013)
    236. Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells. (PubMed id 23228483)1 Giordano C....AndA^ S. (Mol Oncol 2013)
    237. Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo. (PubMed id 22729780)1 Sarkar S....Mandal C. (Int. J. Cancer 2013)
    238. Activity of the heat shock protein 90 inhibitor ganetespib in melanoma. (PubMed id 23418523)1 Wu X....Hodi F.S. (PLoS ONE 2013)
    239. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. (PubMed id 23904609)1 Yang S.W....Chung C.H. (J. Neurosci. 2013)
    240. Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. (PubMed id 23963841)1 Iwai C....Hisatome I. (Cardiovasc. Res. 2013)
    241. Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen. (PubMed id 23912458)1 Donley C....Robson T. (Oncogene 2013)
    242. Secreted heat shock protein 90I+ (HSP90I+) induces nuclear factor-I_B-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion. (PubMed id 23386606)1 Chen W.S....Huang T.S. (J. Biol. Chem. 2013)
    243. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    244. Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome. (PubMed id 23359685)1 French J.B....Benkovic S.J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    245. Molecular mechanism of 17-allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL receptor tyrosine kinase degradation. (PubMed id 23629654)1 Krishnamoorthy G.P....Melillo R.M. (J. Biol. Chem. 2013)
    246. Oncogene PKCI/ controls INrf2-Nrf2 interaction in normal and cancer cells through phosphorylation of INrf2. (PubMed id 24127568)1 Niture S.K....Jaiswal A.K. (J. Cell. Sci. 2013)
    247. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
    248. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    249. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    250. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. (PubMed id 22898980)1 Bukong T.N....Szabo G. (Hepatology 2013)
    251. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    252. SUMO-1 is associated with a subset of lysosomes in glial protein aggregate diseases. (PubMed id 23229893)1 Wong M.B....Pountney D.L. (Neurotox Res 2013)
    253. Ca2+/S100 proteins act as upstream regulators of the chaperone-associated ubiquitin ligase CHIP (C terminus of Hsc70-interacting protein). (PubMed id 23344957)1 Shimamoto S....Kobayashi R. (J. Biol. Chem. 2013)
    254. Distinct roles of molecular chaperones HSP90I+ and HSP90I^ in the biogenesis of KCNQ4 channels. (PubMed id 23431407)1 Gao Y....Nie L. (PLoS ONE 2013)
    255. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)1 New M....La Thangue N.B. (Cell Death Differ. 2013)
    256. Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease. (PubMed id 23114515)1 Sinadinos C....Wyttenbach A. (J. Alzheimers Dis. 2013)
    257. C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances. (PubMed id 22824801)1 Muller P....Vojtesek B. (Oncogene 2013)
    258. Hsp90 - a potential prognostic marker in CML. (PubMed id 23190580)1 ZA!A8kovA! M....MoravcovA! J. (amp 2013)
    259. Effect of HSP90 inhibitor in pheochromocytoma PC12 cells: an experimental investigation. (PubMed id 23873112)1 Zhang C....Zhu Y. (Tumour Biol. 2013)
    260. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    261. Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. (PubMed id 23569248)1 Yang Y....Bhalla K.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    262. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. (PubMed id 23482560)1 Donnelly B.F....Subramanya A.R. (J. Biol. Chem. 2013)
    263. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    264. Regulation of survival and chemoresistance by HSP90AA1 in ovarian cancer SKOV3 cells. (PubMed id 23135731)1 Chu S.H....Li L. (Mol. Biol. Rep. 2013)
    265. The effects of Hsp90 expression alteration on spinal metastases of breast carcinoma. (PubMed id 23456764)1 Yan W....Qian M. (Tumour Biol. 2013)
    266. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    267. Analysis of conformational determinants underlying HSP90-kinase interaction. (PubMed id 23844194)1 Kancha R.K....Duyster J. (PLoS ONE 2013)
    268. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    269. Heat shock protein 90 (Hsp90) selectively regulates the stability of KDM4B/JMJD2B histone demethylase. (PubMed id 23589305)1 Ipenberg I....Ayoub N. (J. Biol. Chem. 2013)
    270. Inhibition of histone deacetylase activity suppresses IFN-I^ induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. (PubMed id 23729439)1 Gao B....Xiong S. (J. Immunol. 2013)
    271. HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-I_B activation and HTLV-1 replication. (PubMed id 24109220)1 Gao L. and Harhaj E.W. (J. Virol. 2013)
    272. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. (PubMed id 24126057)1 Tsen F....Li W. (Mol. Cell. Biol. 2013)
    273. Nuclear transport of Epstein-Barr virus DNA polymerase is dependent on the BMRF1 polymerase processivity factor and molecular chaperone Hsp90. (PubMed id 23552409)1 Kawashima D....Tsurumi T. (J. Virol. 2013)
    274. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
    275. Recruitment of a cytoplasmic chaperone relay by the A2A adenosine receptor. (PubMed id 23965991)1 Bergmayr C....Gruber C.W. (J. Biol. Chem. 2013)
    276. TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function. (PubMed id 23362263)1 Zhang J....Chen X. (J. Biol. Chem. 2013)
    277. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells. (PubMed id 22849407)1 Kang S.A....Lee S.T. (Biochem. J. 2012)
    278. Hemin, an iron-binding porphyrin, inhibits HIF-1I+ induction through its binding with heat shock protein 90. (PubMed id 21413014)1 Lee J.M....Kim S.G. (Int. J. Cancer 2012)
    279. Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. (PubMed id 22367781)1 Rao R....Bhalla K.N. (Mol. Cancer Ther. 2012)
    280. Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy. (PubMed id 22144665)1 Ying W....Koya K. (Mol. Cancer Ther. 2012)
    281. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. (PubMed id 22542455)1 Lin Z....Fang D. (Mol. Cell 2012)
    282. Cdc37/Hsp90 protein-mediated regulation of IRE1I+ protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. (PubMed id 22199355)1 Ota A. and Wang Y. (J. Biol. Chem. 2012)
    283. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    284. Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif. (PubMed id 22848402)1 Beck R....Verrax J. (PLoS ONE 2012)
    285. Down-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cells. (PubMed id 23256568)1 Wang Q....Liu X. (Cancer Cell Int. 2012)
    286. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    287. Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells. (PubMed id 22480737)1 Weng S.H....Lin Y.W. (Biochem. Pharmacol. 2012)
    288. Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (PLoS ONE 2012)
    289. Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. (PubMed id 22869522)1 Liu X.S....Liu X. (Mol. Cell. Biol. 2012)
    290. HILI inhibits TGF-I^ signaling by interacting with Hsp90 and promoting TI^R degradation. (PubMed id 22848678)1 Zhang K....Ma Y. (PLoS ONE 2012)
    291. Heat shock protein 90I+ (Hsp90I+) is phosphorylated in response to DNA damage and accumulates in repair foci. (PubMed id 22270370)1 Quanz M....Dutreix M. (J. Biol. Chem. 2012)
    292. Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90. (PubMed id 23272037)1 Prota L.F....Guggino W.B. (PLoS ONE 2012)
    293. HSP90, HSPA8, HIF-1 alpha and HSP70-2 polymorphisms in breast cancer: a case-control study. (PubMed id 23065205)1 Zagouri F....Papadimitriou C.A. (Mol. Biol. Rep. 2012)
    294. Identification of HSP90 as a new GABARAPL1 (GEC1)-interacting protein. (PubMed id 22120110)1 Seguin-Py S....Delage-Mourroux R. (Biochimie 2012)
    295. Regulation of endothelial barrier function by TGF-I^ type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90. (PubMed id 21465483)1 Antonov A.S....Verin A.D. (J. Cell. Physiol. 2012)
    296. Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90. (PubMed id 22318716)1 Li J....He J. (Acta Biochim. Biophys. Sin. (Shanghai) 2012)
    297. Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer. (PubMed id 22510516)1 Cheng Q....Lyerly H.K. (Breast Cancer Res. 2012)
    298. Shotgun proteomics and network analysis of ubiquitin-related proteins from human breast carcinoma epithelial cells. (PubMed id 21853274)1 Zhou J....Liang S. (Mol. Cell. Biochem. 2012)
    299. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    300. Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1. (PubMed id 21860411)1 Gaude H....Forcet C. (Oncogene 2012)
    301. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    302. Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation. (PubMed id 22490666)1 Kim M.G....Oh J.W. (Biochem. Biophys. Res. Commun. 2012)
    303. Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s. (PubMed id 22975376)1 Chae Y.C....Altieri D.C. (Cancer Cell 2012)
    304. The hERG channel is dependent upon the Hsp90I+ isoform for maturation and trafficking. (PubMed id 22554505)1 Peterson L.B....Blagg B.S. (Mol. Pharm. 2012)
    305. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    306. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. (PubMed id 22128174)1 Peng H.M....Osawa Y. (J. Biol. Chem. 2012)
    307. The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. (PubMed id 22612223)1 Rudenko I.N....Cookson M.R. (Biochem. J. 2012)
    308. Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. (PubMed id 22384180)1 Qu X....Hou J. (PLoS ONE 2012)
    309. Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: balancing muscle protection and destruction. (PubMed id 21855341)1 Paepe B.D....Bleecker J.L. (Neuromuscul. Disord. 2012)
    310. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)
    311. Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. (PubMed id 22843495)1 Giessrigl B....Krupitza G. (Hum. Mol. Genet. 2012)
    312. Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis. (PubMed id 22592212)1 Koizumi H....Yano S. (J Thorac Oncol 2012)
    313. Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors. (PubMed id 22194440)1 Mayer P....Bergmann F. (Endocr. Relat. Cancer 2012)
    314. Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. (PubMed id 22952420)1 Ahsan A....Nyati M.K. (Neoplasia 2012)
    315. Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion. (PubMed id 22912728)1 El Hamidieh A....Patsavoudi E. (PLoS ONE 2012)
    316. Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells. (PubMed id 22935698)1 Iwai A....Neckers L. (Cell Cycle 2012)
    317. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (J. Clin. Invest. 2012)
    318. Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence. (PubMed id 23285036)1 Magen S....Parvari R. (PLoS ONE 2012)
    319. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    320. Thr90 phosphorylation of Hsp90I+ by protein kinase A regulates its chaperone machinery. (PubMed id 21919888)1 Wang X....Luo Y. (Biochem. J. 2012)
    321. Synergistic effect of heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin and X-rays, but not carbon-ion beams, on lethality in human oral squamous cell carcinoma cells. (PubMed id 22843619)1 Musha A....Nakano T. (J. Radiat. Res. 2012)
    322. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. (PubMed id 22674575)1 Jinwal U.K....Dickey C.A. (J. Biol. Chem. 2012)
    323. Expression pattern of PRM2, HSP90 and WNT5A in male partners of couples experiencing idiopathic recurrent miscarriages. (PubMed id 23271023)1 Kumar K....Dada R. (J. Genet. 2012)
    324. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)
    325. Role of FAP48 in HIV-associated lipodystrophy. (PubMed id 22678819)1 Esposito V....Chirianni A. (J. Cell. Biochem. 2012)
    326. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    327. Characterization of the Cullin7 E3 ubiquitin ligase--heterodimerization of cullin substrate receptors as a novel mechanism to regulate cullin E3 ligase activity. (PubMed id 21946088)1 Ponyeam W. and Hagen T. (Cell. Signal. 2012)
    328. Effect of HSP70 and 90 in modulation of JNK, ERK expression in preeclamptic placental endothelial cell. (PubMed id 22689214)1 Padmini E....Lavanya S. (Cell Biochem. Biophys. 2012)
    329. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. (PubMed id 22989880)1 Hance M.W....Isaacs J.S. (J. Biol. Chem. 2012)
    330. Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. (PubMed id 22837396)1 Ghosh A. and Stuehr D.J. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    331. Hyperthermia stimulates HIV-1 replication. (PubMed id 22807676)1 Roesch F....Schwartz O. (PLoS Pathog. 2012)
    332. Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. (PubMed id 22451720)1 Azoitei N....Scholl C. (J. Exp. Med. 2012)
    333. Targeting I^-tubulin:CCT-I^ complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca(2+) entry, mitochondrial perturbation and caspase overactivation. (PubMed id 23190606)1 Lin Y.F....Liang P.H. (amp 2012)
    334. Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-I^ type II receptor. (PubMed id 22964853)1 Noh H....Ziyadeh F. ( a journal of technical methods and pathology 2012)
    335. BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation. (PubMed id 22869732)1 Stecklein S.R....Jensen R.A. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    336. Opposing actions of heat shock protein 90 and 70 regulate nicotinamide adenine dinucleotide phosphate oxidase stability and reactive oxygen species production. (PubMed id 23023377)1 Chen F....Fulton D.J. (Arterioscler. Thromb. Vasc. Biol. 2012)
    337. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    338. The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis. (PubMed id 22653663)1 Cunningham C.N....Agard D.A. (Protein Sci. 2012)
    339. Heat Shock Protein 90 is overexpressed in high-risk myelodysplastic syndromes and associated with higher expression and activation of Focal Adhesion Kinase. (PubMed id 23047954)1 Flandrin-Gresta P....Campos L. (Oncotarget 2012)
    340. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    341. Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins. (PubMed id 22504172)1 Sun L....Matts R.L. (Biochim. Biophys. Acta 2012)
    342. The interaction between human initiation factor eIF3 subunit c and heat-shock protein 90: a necessary factor for translation mediated by the hepatitis C virus internal ribosome entry site. (PubMed id 22016036)1 Ujino S....Takaku H. (Virus Res. 2012)
    343. Mechanism of JNK signal regulation by placental HSP70 and HSP90 in endothelial cell during preeclampsia. (PubMed id 22409343)1 Padmini E....Srinivasan L. (Toxicol. Mech. Methods 2012)
    344. PKCI/ promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PubMed id 22304920)1 Lau E....Ronai Z.A. (Cell 2012)
    345. Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response. (PubMed id 22351691)1 Manni S....Piazza F. (Clin. Cancer Res. 2012)
    346. Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus. (PubMed id 22543833)1 Shimp S.K....Reilly C.M. (amp 2012)
    347. A catalogue of putative HIV-1 protease host cell substrates. (PubMed id 22944692)1 Impens F....Gevaert K. (Biol. Chem. 2012)
    348. Mitochondrial heat shock protein-90 modulates vascular smooth muscle cell survival and the vascular injury response in vivo. (PubMed id 22841823)1 Hoel A.W....Conte M.S. (Am. J. Pathol. 2012)
    349. The novel oral Hsp90 inhibitor NVP-HSP990 exhibits potent and broad-spectrum antitumor activities in vitro and in vivo. (PubMed id 22246440)1 Menezes D.L....Gao Z. (Mol. Cancer Ther. 2012)
    350. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression. (PubMed id 22271573)1 Schulz R....Moll U.M. (J. Exp. Med. 2012)
    351. Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity. (PubMed id 22315411)1 Tsutsumi S....Neckers L.M. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    352. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    353. A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair. (PubMed id 23139789)1 Bruns A.F....Ponnambalam S. (PLoS ONE 2012)
    354. The p23 molecular chaperone and GCN5 acetylase jointly modulate protein-DNA dynamics and open chromatin status. (PubMed id 23022381)1 Zelin E....Freeman B.C. (Mol. Cell 2012)
    355. Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP. (PubMed id 21268072)1 Wang J....Guo Q.L. (J. Cell. Biochem. 2011)
    356. Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. (PubMed id 20585984)1 Redlak M.J. and Miller T.A. (Dig. Dis. Sci. 2011)
    357. Stoichiometry and thermodynamics of the interaction between the C-terminus of human 90kDa heat shock protein Hsp90 and the mitochondrial translocase of outer membrane Tom70. (PubMed id 21781956)1 Gava L.M....Ramos C.H. (Arch. Biochem. Biophys. 2011)
    358. Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40. (PubMed id 21146485)1 Park M.S.... Chan W.K. (Anal. Biochem. 2011)
    359. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    360. Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-I^1/focal adhesion kinase/c-Src signaling pathway. (PubMed id 21369706)1 Liu X....Guo C. (Oncol. Rep. 2011)
    361. Effective targeting of triple-negative breast cancer cells by PF-4942847, a novel oral inhibitor of Hsp 90. (PubMed id 21715568)1 Mehta P.P....Yin M.J. (Clin. Cancer Res. 2011)
    362. Serum levels of HSP90 in the continuum of breast ductal and lobular lesions. (PubMed id 21709012)1 Zagouri F....Gounaris A. (In Vivo 2011)
    363. The role of heat shock protein 90 in the regulation of tumor cell apoptosis. (PubMed id 22268041)1 Kaigorodova E.V....Maroshkina A.N. (Bull. Exp. Biol. Med. 2011)
    364. Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2. (PubMed id 22028380)1 Abu-Farha M....Couture J.F. (J Mol Cell Biol 2011)
    365. Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). (PubMed id 21454478)1 Wang L....Wu J.W. (J. Biol. Chem. 2011)
    366. Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90. (PubMed id 21330372)1 Jung G....Albanesi J.P. (J. Biol. Chem. 2011)
    367. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    368. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    369. The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. (PubMed id 21157430)1 Chymkowitch P....Egly J.M. (EMBO J. 2011)
    370. Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. (PubMed id 21543763)1 Xu C....Chuang T.H. (FASEB J. 2011)
    371. [FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability]. (PubMed id 21875461)1 Liu X.G....Guo C.A. (Zhonghua Zhong Liu Za Zhi 2011)
    372. Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. (PubMed id 20966961)1 Tinel A....Tschopp J. (Cell Death Differ. 2011)
    373. Clathrin facilitates the morphogenesis of retrovirus particles. (PubMed id 21738476)1 Zhang F....Bieniasz P.D. (PLoS Pathog. 2011)
    374. Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. (PubMed id 20981255)1 RyhAonen T....Kaarniranta K. (amp 2011)
    375. Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. (PubMed id 21372220)1 Breinig M....Rieker R.J. (Clin. Cancer Res. 2011)
    376. Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle. (PubMed id 21170051)1 Li J....Buchner J. (amp 2011)
    377. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. (PubMed id 21183720)1 KaragAPz G.E....RA1diger S.G. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    378. An interaction network predicted from public data as a discovery tool: application to the Hsp90 molecular chaperone machine. (PubMed id 22022502)1 EcheverrA-a P.C....Picard D. (PLoS ONE 2011)
    379. Phosphorylation of a heme-regulated eukaryotic initiation factor 2I+ kinase enhances the interaction with heat-shock protein 90 and substantially upregulates kinase activity. (PubMed id 21787283)1 Mukai K....Igarashi J. (Protein Pept. Lett. 2011)
    380. Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. (PubMed id 22079093)1 Fedorova O.A....Barlev N.A. (Biochem. Biophys. Res. Commun. 2011)
    381. Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. (PubMed id 21875325)1 Li Y....Sun D. (Nutr Cancer 2011)
    382. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    383. Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase. (PubMed id 21767636)1 Su C.H....Lee W.P. (Cell. Signal. 2011)
    384. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    385. Dynamic Interaction of Hsp90 with Its Client Protein p53. (PubMed id 21658391)1 Park S.J....Dyson H.J. (J. Mol. Biol. 2011)
    386. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    387. Molecular chaperone Hsp90 regulates REV1-mediated mutagenesis. (PubMed id 21690293)1 Pozo F.M....Yamashita T. (Mol. Cell. Biol. 2011)
    388. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. (PubMed id 21360678)1 Skarra D.V....Honkanen R.E. (Proteomics 2011)
    389. Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage. (PubMed id 21566061)1 Ha K....Bhalla K.N. (Mol. Cancer Ther. 2011)
    390. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    391. The C-terminus of Hsp70-interacting protein promotes Met receptor degradation. (PubMed id 21325980)1 Jang K.W....Lim S.P. (J Thorac Oncol 2011)
    392. Inhibition of RPE cell sterile inflammatory responses and endotoxin-induced uveitis by a cell-impermeable HSP90 inhibitor. (PubMed id 22019372)1 Qin S....Rodrigues G.A. (Exp. Eye Res. 2011)
    393. Heat shock protein 90 facilitates formation of the HBV capsid via interacting with the HBV core protein dimers. (PubMed id 21126747)1 Shim H.Y....Jung G. (Virology 2011)
    394. A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion. (PubMed id 21408136)1 Gopal U....Isaacs J.S. (PLoS ONE 2011)
    395. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (amp 2011)
    396. A bead-based approach for large-scale identification of in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (Proteomics 2011)
    397. Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90. (PubMed id 21871133)1 Zhao M....Yu X.D. (Mol. Cancer 2011)
    398. Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. (PubMed id 21248063)1 Sun H....Donato N.J. (Blood 2011)
    399. Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. (PubMed id 21235734)1 Horibe T....Kawakami K. (J Transl Med 2011)
    400. HSP90 is crucial for regulation of LAT expression in activated T cells. (PubMed id 21251717)1 Hayashi K. and Kamikawa Y. (Mol. Immunol. 2011)
    401. Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis. (PubMed id 21571784)1 Bijlmakers M.J....Capon F. (Hum. Mol. Genet. 2011)
    402. Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. (PubMed id 21700222)1 Southworth D.R. and Agard D.A. (Mol. Cell 2011)
    403. Ubiquitination and downregulation of ErbB2 and estrogen receptor-alpha by kinase inhibitor MP-412 in human breast cancer cells. (PubMed id 21503962)1 Suzuki T....Nakamura H. (J. Cell. Biochem. 2011)
    404. Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B. (PubMed id 21177334)1 Hashiramoto A....Shiozawa S. (Rheumatology (Oxford) 2011)
    405. Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease. (PubMed id 22160715)1 Lu J....Zhuang Z. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    406. TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription. (PubMed id 21984809)1 Sato T....Hatakeyama S. (J. Cell. Sci. 2011)
    407. Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation. (PubMed id 21487019)1 Laederich M.B....Horton W.A. (J. Biol. Chem. 2011)
    408. IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. (PubMed id 21642987)1 Pichlmair A....Superti-Furga G. (Nat. Immunol. 2011)
    409. Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis. (PubMed id 21998300)1 Wang S.A....Hung J.J. (J. Biol. Chem. 2011)
    410. Role of low native state kinetic stability and interaction of partially unfolded states with molecular chaperones in the mitochondrial protein mistargeting associated with primary hyperoxaluria. (PubMed id 21103899)1 Pey A.L....Sanchez-Ruiz J.M. (Amino Acids 2011)
    411. Hsp90 is involved in the formation of P-bodies and stress granules. (PubMed id 21439943)1 Matsumoto K....Minami Y. (Biochem. Biophys. Res. Commun. 2011)
    412. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (Stem Cells 2011)
    413. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    414. Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. (PubMed id 21478269)1 Li D....Moll U.M. (Mol. Cancer Res. 2011)
    415. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    416. The NS1 protein of influenza A virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: implication for virus-induced apoptosis. (PubMed id 21501532)1 Zhang C....Huang P. (Virol. J. 2011)
    417. Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. (PubMed id 20628368)1 Liu X.Y....Wang C. (Cell Res. 2010)
    418. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    419. Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP. (PubMed id 20704274)1 Kundrat L. and Regan L. (Biochemistry 2010)
    420. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. (PubMed id 20924358)1 Yan S....Yi J. (EMBO J. 2010)
    421. CHIP promotes human telomerase reverse transcriptase degradation and negatively regulates telomerase activity. (PubMed id 20959453)1 Lee J.H....Chung I.K. (J. Biol. Chem. 2010)
    422. Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias. (PubMed id 20651072)1 Bansal H....Padmanabhan S. (Blood 2010)
    423. Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (J. Proteome Res. 2010)
    424. CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates. (PubMed id 20618441)1 Stankiewicz M....Mayer M.P. (FEBS J. 2010)
    425. The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. (PubMed id 21151955)1 Imai Y....Takahashi R. (PLoS Genet. 2010)
    426. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. (PubMed id 20801936)1 Takai H.... Pavletich N.P. (Genes Dev. 2010)
    427. The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells. (PubMed id 20129057)1 Sekimoto T....Yamashita T. (Mol. Cell 2010)
    428. The program for processing newly synthesized histones H3.1 and H4. (PubMed id 20953179)1 Campos E.I.... Reinberg D. (Nat. Struct. Mol. Biol. 2010)
    429. Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. (PubMed id 20663926)1 Rao R....Bhalla K.N. (Mol. Cancer Ther. 2010)
    430. Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. (PubMed id 20353823)1 Cheng M.B....Shen Y.F. (Cell. Signal. 2010)
    431. Hsp90 modulates CAG repeat instability in human cells. (PubMed id 20373063)1 Mittelman D....Wilson J.H. (amp 2010)
    432. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. (PubMed id 19786027)1 Xue J....Fang J. (Gastroenterology 2010)
    433. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. (PubMed id 20642453)1 Nichols R.J....Alessi D.R. (Biochem. J. 2010)
    434. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. (PubMed id 20305087)1 Mak A.B....Moffat J. (amp 2010)
    435. Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation. (PubMed id 20553606)1 McCready J....Jay D.G. (BMC Cancer 2010)
    436. Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo. (PubMed id 20226818)1 Zurawska A....Bieganowski P. (Biochim. Biophys. Acta 2010)
    437. Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. (PubMed id 20661446)1 SchA1lke J.P....Rein T. (PLoS ONE 2010)
    438. Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. (PubMed id 20949042)1 Zach S.... Gillardon F. (PLoS ONE 2010)
    439. Secreted heat shock protein 90alpha induces colorectal cancer cell invasion through CD91/LRP-1 and NF-kappaB-mediated integrin alphaV expression. (PubMed id 20558745)1 Chen J.S....Huang T.S. (J. Biol. Chem. 2010)
    440. Novel interactors and a role for supervillin in early cytokinesis. (PubMed id 20309963)1 Smith T.C....Luna E.J. (Cytoskeleton (Hoboken) 2010)
    441. AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay. (PubMed id 20371770)1 Izumi N.... Ohno S. (Sci. Signal. 2010)
    442. A screen for deubiquitinating enzymes involved in the Ga88/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. (PubMed id 20930503)1 Aressy B....Ducommun B. (Cell Cycle 2010)
    443. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    444. FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells. (PubMed id 20048054)1 Ni L....Paschal B.M. (Mol. Cell. Biol. 2010)
    445. Proteomic analysis reveals novel binding partners of MIP-T3 in human cells. (PubMed id 20391533)1 Guo C.W....Kitazato K. (Proteomics 2010)
    446. HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells. (PubMed id 20237157)1 Johnston M....Hutvagner G. (Mol. Biol. Cell 2010)
    447. Bcl-2 regulates HIF-1alpha protein stabilization in hypoxic melanoma cells via the molecular chaperone HSP90. (PubMed id 20668552)1 Trisciuoglio D....Del Bufalo D. (PLoS ONE 2010)
    448. Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions. (PubMed id 20602789)1 Zagouri F....Zografos G.C. (BMC Cancer 2010)
    449. Can hsp90alpha-targeted siRNA combined with TMZ be a future therapy for glioma? (PubMed id 20210521)1 Cruickshanks N....Shervington A. (Cancer Invest. 2010)
    450. CKS proteins protect mitochondrial genome integrity by interacting with mitochondrial single-stranded DNA-binding protein. (PubMed id 19786724)1 Radulovic M....Yu V.P. (amp 2010)
    451. Expression of HSP90 in gastrointestinal stromal tumours and mesenchymal tumours. (PubMed id 20546334)1 Kang G.H....Kim S. (Histopathology 2010)
    452. Decreased Hsp90 expression in infiltrative lobular carcinoma: an immunohistochemical study. (PubMed id 20691061)1 Zagouri F....Zografos G. (BMC Cancer 2010)
    453. Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy. (PubMed id 20540933)1 Lu T.L....Lu T.J. (Biochem. Biophys. Res. Commun. 2010)
    454. Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV. (PubMed id 20451233)1 Qin Z....Parsons C. (Virology 2010)
    455. Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein. (PubMed id 20937817)1 Vozzolo L....Fassati A. (J. Biol. Chem. 2010)
    456. NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90. (PubMed id 20133715)1 Yang Y.... Zhou T. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    457. The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability. (PubMed id 20675372)1 Zhu X.J....Zhou T. (J. Biol. Chem. 2010)
    458. ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein. (PubMed id 20688913)1 Walerych D....Zylicz A. (J. Biol. Chem. 2010)
    459. Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition. (PubMed id 21129190)1 Hackl C....Stoeltzing O. (BMC Cancer 2010)
    460. Heat shock proteins: cell protection through protein triage. (PubMed id 20694452)1 Lanneau D....Garrido C. (ScientificWorldJournal 2010)
    461. Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments. (PubMed id 20804554)1 Zhang Y.J....Petrucelli L. (Mol Neurodegener 2010)
    462. Heat shock protein 90 interacts with vitamin D receptor in human leukemia cells. (PubMed id 20138989)1 Marcinkowska E. and Gocek E. (J. Steroid Biochem. Mol. Biol. 2010)
    463. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PubMed id 20458337)1 Buschow S.I....Stoorvogel W. (Immunol. Cell Biol. 2010)
    464. HSP90 and its R2TP/Prefoldin-like cochaperone are involved in the cytoplasmic assembly of RNA polymerase II. (PubMed id 20864038)1 Boulon S....Bertrand E. (Mol. Cell 2010)
    465. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    466. Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein. (PubMed id 20724477)1 Choi Y.K....Kim Y.M. (J. Biol. Chem. 2010)
    467. Methylglyoxal alters the function and stability of critical components of the protein quality control. (PubMed id 20885985)1 Bento C.F....Pereira P. (PLoS ONE 2010)
    468. Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-I+ and IL-8/CXCL8 mRNA: new insights into the involvement of 'alarmins'. (PubMed id 20731692)1 Dickel H....Skrygan M. (Contact Derm. 2010)
    469. Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation. (PubMed id 20864537)1 Niture S.K. and Jaiswal A.K. (J. Biol. Chem. 2010)
    470. Assessment of heat shock protein (HSP60, HSP72, HSP90, and HSC70) expression in cultured limbal stem cells following air lifting. (PubMed id 20806039)1 Ebrahimi M....Baharvand H. (Mol. Vis. 2010)
    471. Bag1 directly routes immature BCR-ABL for proteasomal degradation. (PubMed id 20675402)1 Tsukahara F. and Maru Y. (Blood 2010)
    472. Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis. (PubMed id 20089831)1 Koulov A.V....Balch W.E. (Mol. Biol. Cell 2010)
    473. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PubMed id 20195357)1 Miyamoto-Sato E....Yanagawa H. (PLoS ONE 2010)
    474. Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. (PubMed id 20404110)1 Davies A.E. and Kaplan K.B. (J. Cell Biol. 2010)
    475. Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. (PubMed id 19716405)1 Lee J.Y....Chung K.C. (Biochim. Biophys. Acta 2009)
    476. Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates. (PubMed id 19329795)1 Bhattacharyya S....Groden J. (J. Biol. Chem. 2009)
    477. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. (PubMed id 19167051)1 Weinmann L.... Meister G. (Cell 2009)
    478. The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy. (PubMed id 19965370)1 Wang X....Luo Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    479. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)
    480. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. (PubMed id 19196961)1 Ko H.S....Dawson V.L. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    481. Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex. (PubMed id 19338310)1 Du Y....Chen X. (J. Proteome Res. 2009)
    482. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    483. Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies. (PubMed id 19458189)1 Pare J.M....Hobman T.C. (Mol. Biol. Cell 2009)
    484. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    485. Identification of novel hub genes associated with liver metastasis of gastric cancer. (PubMed id 19569046)1 Chang W....Cao G. (Int. J. Cancer 2009)
    486. Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. (PubMed id 19596686)1 Matafora V....Bachi A. (amp 2009)
    487. Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53. (PubMed id 19136058)1 Giustiniani J....Baillet A. (Cell. Signal. 2009)
    488. Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. (PubMed id 19826009)1 Sen S....West A.B. (J. Biol. Chem. 2009)
    489. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. (PubMed id 19356729)1 Kim Y....Jeoung D. (Eur. J. Pharmacol. 2009)
    490. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    491. Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. (PubMed id 19536328)1 Ding X. and Goldberg M.S. (PLoS ONE 2009)
    492. [In vitro study of expression and effects of HSP70/HSP90 in nasopharyngeal carcinoma cells after thermotherapy]. (PubMed id 19764559)1 Cui X.B....Guo L.L. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009)
    493. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    494. The levels of retinoic acid-inducible gene I are regulated by heat shock protein 90-alpha. (PubMed id 19234166)1 Matsumiya T....Stafforini D.M. (J. Immunol. 2009)
    495. Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. (PubMed id 19193894)1 Liu J....Zhang J. (J. Neurosci. 2009)
    496. Cochaperone activity of human butyrate-induced transcript 1 facilitates hepatitis C virus replication through an Hsp90-dependent pathway. (PubMed id 19656872)1 Taguwa S....Matsuura Y. (J. Virol. 2009)
    497. The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. (PubMed id 19706771)1 DaSilva J....Parsons S.J. (Cancer Res. 2009)
    498. CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation. (PubMed id 19237536)1 Xie P....Li H. (Mol. Cell. Biol. 2009)
    499. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. (PubMed id 19350847)1 Hacker S....Ankersmit H.J. (Clin. Lab. 2009)
    500. The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein. (PubMed id 19759002)1 Falsone S.F....Zangger K. (J. Biol. Chem. 2009)
    501. [Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics]. (PubMed id 19635199)1 Zhang W.L....Yue L.T. (Ai Zheng 2009)
    502. Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. (PubMed id 19110265)1 Martins-de-Souza D....Dias-Neto E. (J Psychiatr Res 2009)
    503. [Mechanism of C-reactive protein on proliferation of multiple myeloma U266 cells]. (PubMed id 19840459)1 Yang Y.R....Zhou Y.A. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    504. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PubMed id 19287380)1 Maddika S. and Chen J. (Nat. Cell Biol. 2009)
    505. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    506. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. (PubMed id 19716330)1 Fabian M.R.... Sonenberg N. (Mol. Cell 2009)
    507. Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. (PubMed id 18485875)1 Martinvalet D....Lieberman J. (Cell 2008)
    508. Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. (PubMed id 18457437)1 Forsman A....Rymo L. (J. Proteome Res. 2008)
    509. HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. (PubMed id 18195352)1 Chakraborty A....Snyder S.H. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    510. The tale of two domains: proteomics and genomics analysis of SMYD2, a new histone methyltransferase. (PubMed id 18065756)1 Abu-Farha M....Figeys D. (Mol. Cell. Proteomics 2008)
    511. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. (PubMed id 18556464)1 Sun F....Frizzell R.A. (FASEB J. 2008)
    512. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. (PubMed id 18003639)1 Weihofen A....Selkoe D.J. (Hum. Mol. Genet. 2008)
    513. Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors. (PubMed id 18211808)1 Park J.H....Kim T.Y. (Biochem. Biophys. Res. Commun. 2008)
    514. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)
    515. Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution. (PubMed id 18511558)1 Colombo G....Verkhivker G. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    516. Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment. (PubMed id 19367720)2 Carrascal M.... Abian J. (J. Proteome Res. 2008)
    517. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. (PubMed id 18256191)2 Hawkins T.A.... Wilson S.W. (Development 2008)
    518. Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. (PubMed id 18318008)2 Han G.... Gu J. (Proteomics 2008)
    519. Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells. (PubMed id 18820283)1 Kim R.H....Kang M.K. (Carcinogenesis 2008)
    520. Overexpression of telomerase-associated chaperone proteins in prostatic intraepithelial neoplasia and carcinomas. (PubMed id 18695913)1 Elmore L.W....Holt S.E. (Oncol. Rep. 2008)
    521. Heat shock protein derivatives for delivery of antigens to antigen presenting cells. (PubMed id 17980980)7 Nishikawa M....Takakura Y. (Int J Pharm 2008)
    522. MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells. (PubMed id 18394702)1 Nishioka C....Yokoyama A. (Leuk. Res. 2008)
    523. Phosphoproteome of resting human platelets. (PubMed id 18088087)2 Zahedi R.P.... Sickmann A. (J. Proteome Res. 2008)
    524. The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex. (PubMed id 18408180)1 Hidalgo-de-Quintana J....van der Spuy J. (amp 2008)
    525. NSF, Unc-18-1, dynamin-1 and HSP90 are inclusion body components in neuronal intranuclear inclusion disease identified by anti-SUMO-1-immunocapture. (PubMed id 18836734)1 Pountney D.L....Gai W.P. (Acta Neuropathol. 2008)
    526. The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. (PubMed id 18367605)1 Wang L....Cai H. (J. Neurosci. 2008)
    527. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)1 Windheim M.... Cohen P. (Biochem. J. 2008)
    528. Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation. (PubMed id 19138996)1 Hughes D....Dannenberg A.J. (Cancer Prev Res (Phila) 2008)
    529. HES1 is a novel interactor of the Fanconi anemia core complex. (PubMed id 18550849)1 Tremblay C.S....Carreau M. (Blood 2008)
    530. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PubMed id 18332089)4 Goodarzi M.O....Azziz R. (Hum. Reprod. 2008)
    531. MafG controls the hypoxic response of cells by accumulating HIF-1alpha in the nuclei. (PubMed id 18538669)1 Ueda K....Imaoka S. (FEBS Lett. 2008)
    532. A novel HSP90 chaperone complex regulates intracellular vesicle transport. (PubMed id 18270269)1 Lotz G.P....Obermann W.M. (J. Cell. Sci. 2008)
    533. MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. (PubMed id 18094050)1 Hirayama S.... Nagata K. (Mol. Biol. Cell 2008)
    534. Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. (PubMed id 18388150)1 Berry N.B....Nephew K.P. (Mol. Endocrinol. 2008)
    535. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. (PubMed id 18550537)1 Kabuta T....Wada K. (J. Biol. Chem. 2008)
    536. X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility. (PubMed id 19011619)1 Dogan T....Rajalingam K. (Nat. Cell Biol. 2008)
    537. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    538. ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. (PubMed id 18617639)4 Litonjua A.A....Weiss S.T. (Am. J. Respir. Crit. Care Med. 2008)
    539. CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. (PubMed id 18784277)1 Morishima Y....Lieberman A.P. (Hum. Mol. Genet. 2008)
    540. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1 Meierhofer D.... Kaiser P. (J. Proteome Res. 2008)
    541. Structural models and binding site prediction of the C-terminal domain of human Hsp90: a new target for anticancer drugs. (PubMed id 18373550)1 Sgobba M....Rastelli G. (amp 2008)
    542. The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. (PubMed id 18172692)1 Aranda-OrgillAcs B....Schweiger S. (Hum. Genet. 2008)
    543. Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. (PubMed id 18818696)1 Zhang M....Pearl L.H. (EMBO J. 2008)
    544. A novel variant of the putative demethylase gene, s-JMJD1C, is a coactivator of the AR. (PubMed id 17353003)1 Wolf S.S.... Obendorf M. (Arch. Biochem. Biophys. 2007)
    545. VCP/p97 AAA-ATPase does not interact with the endogenous wild-type cystic fibrosis transmembrane conductance regulator. (PubMed id 17272822)1 Goldstein R.F....Collawn J.F. (Am. J. Respir. Cell Mol. Biol. 2007)
    546. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. (PubMed id 17220478)1 Tu L.C....Lin B. (amp 2007)
    547. Diverse effects of Stat1 on the regulation of hsp90alpha gene under heat shock. (PubMed id 17427945)1 Chen X.S....Shen Y.F. (J. Cell. Biochem. 2007)
    548. Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. (PubMed id 17974989)1 Zoubeidi A....Gleave M. (Cancer Res. 2007)
    549. Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase. (PubMed id 17873020)1 Xia T....Catravas J.D. (Am. J. Physiol. Heart Circ. Physiol. 2007)
    550. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)1 Xiao K....Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    551. SGT1 is essential for Nod1 activation. (PubMed id 17420470)1 da Silva Correia J....Ulevitch R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    552. Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1. (PubMed id 17148781)1 Chen Y....Ferraris J.D. (Am. J. Physiol. Renal Physiol. 2007)
    553. Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473)1 Souza-RodrA-gues E....Jaumot M. (Proteomics 2007)
    554. Hsp90 selectively modulates phenotype in vertebrate development. (PubMed id 17397257)1 Yeyati P.L....van Heyningen V. (PLoS Genet. 2007)
    555. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF- 1alpha. (PubMed id 17244529)1 Liu Y.V.... Semenza G.L. (Mol. Cell 2007)
    556. Uncoupling of hormone-dependence from chaperone-dependence in the L701H mutation of the androgen receptor. (PubMed id 17336451)1 Robzyk K....Caplan A.J. (Mol. Cell. Endocrinol. 2007)
    557. Identification of potential protein interactors of Lrrk2. (PubMed id 17400507)1 DAochsel J.C....Farrer M.J. (amp 2007)
    558. CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism. (PubMed id 17317785)1 Kumar P....Querfurth H.W. (Hum. Mol. Genet. 2007)
    559. An acetylation site in the middle domain of Hsp90 regulates chaperone function. (PubMed id 17218278)1 Scroggins B.T....Neckers L. (Mol. Cell 2007)
    560. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. (PubMed id 17435760)1 Mayor A....Tschopp J. (Nat. Immunol. 2007)
    561. Loss of Hsp90 association up-regulates Src-dependent ErbB2 activity. (PubMed id 17030621)1 Xu W....Neckers L. (Mol. Cell. Biol. 2007)
    562. Hsp90 inhibition decreases mitochondrial protein turnover. (PubMed id 17957250)1 Margineantu D.H....Hockenbery D.M. (PLoS ONE 2007)
    563. Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis. (PubMed id 17237281)1 Fu B....Fang J. (Mol. Cancer Ther. 2007)
    564. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    565. Dimerization of Hsp90 is required for in vivo function. Design and analysis of monomers and dimers. (PubMed id 17908693)1 Wayne N. and Bolon D.N. (J. Biol. Chem. 2007)
    566. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. (PubMed id 17304350)1 Dickey C.A....Petrucelli L. (J. Clin. Invest. 2007)
    567. Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. (PubMed id 17210713)1 Farhana L....Fontana J.A. (Cancer Res. 2007)
    568. Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. (PubMed id 17947705)1 Arthur J.C....Ting J.P. (J. Immunol. 2007)
    569. The Bcl-2 regulator FKBP38-calmodulin-Ca2+ is inhibited by Hsp90. (PubMed id 17379601)1 Edlich F....Fischer G. (J. Biol. Chem. 2007)
    570. Hsp90--from signal transduction to cell transformation. (PubMed id 17826744)1 Brown M.A....Tucker P.W. (Biochem. Biophys. Res. Commun. 2007)
    571. Intermolecular relations between the glucocorticoid receptor, ZAP-70 kinase, and Hsp-90. (PubMed id 17222799)1 Bartis D....Berki T. (Biochem. Biophys. Res. Commun. 2007)
    572. Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. (PubMed id 16275660)1 Grelle G.... Wanker E.E. (Mol. Cell. Proteomics 2006)
    573. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    574. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PubMed id 17110338)1 Wang X....Balch W.E. (Cell 2006)
    575. Methylglyoxal downregulates Raf-1 protein through a ubiquitination-mediated mechanism. (PubMed id 16504566)1 Du J....Cai S. (amp 2006)
    576. Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels. (PubMed id 17054904)1 Kise Y....Miki H. (Biochem. Biophys. Res. Commun. 2006)
    577. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha. (PubMed id 16507982)1 Kong X....Caro J. (Mol. Cell. Biol. 2006)
    578. Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors. (PubMed id 16849543)1 Yang S....Arteaga C.L. (Cancer Res. 2006)
    579. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. (PubMed id 16462731)1 Petretti C....Giet R. (EMBO Rep. 2006)
    580. Structure of an Hsp90-Cdc37-Cdk4 complex. (PubMed id 16949366)1 Vaughan C.K....Pearl L.H. (Mol. Cell 2006)
    581. Glucocorticoids cause rapid dissociation of a T-cell-receptor-associated protein complex containing LCK and FYN. (PubMed id 16888650)1 LAPwenberg M....Hommes D.W. (EMBO Rep. 2006)
    582. Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. (PubMed id 16968706)1 Fearns C....Chuang T.H. (J. Biol. Chem. 2006)
    583. Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. (PubMed id 16621797)1 Vij N....Zeitlin P.L. (J. Biol. Chem. 2006)
    584. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone. (PubMed id 16919237)1 Hurst D.R....Samant R.S. (Biochem. Biophys. Res. Commun. 2006)
    585. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. (PubMed id 16278218)1 Wang X....Calderwood S.K. (J. Biol. Chem. 2006)
    586. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. (PubMed id 16698020)1 Kim J.Y.... Park J.H. (FEBS Lett. 2006)
    587. Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation. (PubMed id 16314389)1 Kim T.S....Kim J. (Mol. Biol. Cell 2006)
    588. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    589. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    590. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. (PubMed id 16321986)1 Gloeckner C.J.... Ueffing M. (Hum. Mol. Genet. 2006)
    591. Association between Hsp90 and the ClC-2 chloride channel upregulates channel function. (PubMed id 16049054)1 Hinzpeter A....Fritsch J. (Am. J. Physiol., Cell Physiol. 2006)
    592. Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. (PubMed id 16644868)1 Thomas M....Lieberman A.P. (Hum. Mol. Genet. 2006)
    593. Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. (PubMed id 16394098)1 Yang K....Wang C. (Mol. Biol. Cell 2006)
    594. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. (PubMed id 16951198)1 Qian D.Z....Pili R. (Cancer Res. 2006)
    595. Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. (PubMed id 16809764)1 Lee H.... Seto E. (Mol. Cell. Biol. 2006)
    596. Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). (PubMed id 16396496)1 Foster L.J....Klip A. (J. Proteome Res. 2006)
    597. Theileria-induced constitutive IKK activation is independent of functional Hsp90. (PubMed id 16938294)1 Hermann P. and Dobbelaere D.A. (FEBS Lett. 2006)
    598. Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. (PubMed id 16844778)1 Koga F....Neckers L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    599. [Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]. (PubMed id 16583711)1 Maksimov V.V....Tarantul V.Z. (Genetika 2006)
    600. Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes expressing the HIV protein tat. (PubMed id 15710247)1 Pocernich C.B....Butterfield D.A. (Brain Res. Mol. Brain Res. 2005)
    601. Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. (PubMed id 15791211)1 Park S.J....Takenawa T. (EMBO J. 2005)
    602. Hsp90 is essential for restoring cellular functions of temperature-sensitive p53 mutant protein but not for stabilization and activation of wild-type p53: implications for cancer therapy. (PubMed id 15613472)1 MA1ller P....Vojtesek B. (J. Biol. Chem. 2005)
    603. CHIP interacts with heat shock factor 1 during heat stress. (PubMed id 16293251)1 Kim S.A....Ahn S.G. (FEBS Lett. 2005)
    604. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. (PubMed id 16306228)1 Al-Hakim A.K.... Alessi D.R. (J. Cell Sci. 2005)
    605. Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox. (PubMed id 16288044)1 Mahajan N.P.... Earp H.S. (Cancer Res. 2005)
    606. Phosphoproteomic analysis of synaptosomes from human cerebral cortex. (PubMed id 15822905)1 DeGiorgis J.A.... Dosemeci A. (J. Proteome Res. 2005)
    607. Large-scale analysis of the human ubiquitin-related proteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (Proteomics 2005)
    608. Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia. (PubMed id 16300468)1 Hamblin A.D. and Hamblin T.J. (Expert Opin. Ther. Targets 2005)
    609. Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein. (PubMed id 15664193)1 Jascur T.... Fotedar A. (Mol. Cell 2005)
    610. Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. (PubMed id 16027165)1 Klein J.B....Rane M.J. (J. Biol. Chem. 2005)
    611. CAND1 enhances deneddylation of CUL1 by COP9 signalosome. (PubMed id 16036220)1 Min K.W....Yoon J.B. (Biochem. Biophys. Res. Commun. 2005)
    612. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. (PubMed id 16093354)1 Zhu J.... Tzivion G. (Mol. Biol. Cell 2005)
    613. Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes. (PubMed id 16212417)1 Catimel B....Nice E. (J. Proteome Res. 2005)
    614. Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry. (PubMed id 16335966)1 Vasilescu J....Figeys D. (J. Proteome Res. 2005)
    615. 1H, 13C and 15N backbone resonance assignment of the Hsp90 binding domain of human Cdc37. (PubMed id 16132836)1 Sreeramulu S....Schwalbe H. (J. Biomol. NMR 2005)
    616. Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. (PubMed id 15643424)1 Xu W....Neckers L. (amp 2005)
    617. Dissection of the mitochondrial import and assembly pathway for human Tom40. (PubMed id 15644312)1 Humphries A.D.... Ryan M.T. (J. Biol. Chem. 2005)
    618. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. (PubMed id 16037132)1 Fan M....Nephew K.P. (Mol. Endocrinol. 2005)
    619. Rational design of shepherdin, a novel anticancer agent. (PubMed id 15894266)1 Plescia J....Altieri D.C. (Cancer Cell 2005)
    620. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (amp 2005)
    621. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. (PubMed id 16207813)1 Arndt V....HAPhfeld J. (Mol. Biol. Cell 2005)
    622. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    623. DNA sequence determinants of nuclear protein binding to the c-Ha-ras antioxidant/electrophile response element in vascular smooth muscle cells: identification of Nrf2 and heat shock protein 90 beta as heterocomplex components. (PubMed id 16038408)1 Miller K.P. and Ramos K.S. (amp 2005)
    624. The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. (PubMed id 16004603)1 Katoh K....Maki M. (Biochem. J. 2005)
    625. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. (PubMed id 15870294)1 Spiridonov N.A.... Johnson G.R. (Mol. Cell. Biol. 2005)
    626. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. (PubMed id 16139798)2 Giannakopoulos N.V.... Zhang D.E. (Biochem. Biophys. Res. Commun. 2005)
    627. A human, ATP-independent, RISC assembly machine fueled by pre- miRNA. (PubMed id 16357216)1 Maniataki E. and Mourelatos Z. (Genes Dev. 2005)
    628. Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry. (PubMed id 16226712)1 Niture S.K....Srivenugopal K.S. (Biochem. Biophys. Res. Commun. 2005)
    629. Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. (PubMed id 15798097)1 Shay K.P.... Magnuson N.S. (Mol. Cancer Res. 2005)
    630. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. (PubMed id 16009940)1 Zhao C.... Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    631. A proteomic snapshot of the human heat shock protein 90 interactome. (PubMed id 16263121)1 Falsone S.F....Kungl A.J. (FEBS Lett. 2005)
    632. Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor. (PubMed id 15538384)1 Tateishi Y....Yanagisawa J. (EMBO J. 2004)
    633. Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. (PubMed id 14739935)1 Meyer P....Pearl L.H. (EMBO J. 2004)
    634. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)1 Nagaraja G.M. and Kandpal R.P. (Biochem. Biophys. Res. Commun. 2004)
    635. Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods. (PubMed id 15047060)1 Bernhard O.K....Sheil M.M. (J. Am. Soc. Mass Spectrom. 2004)
    636. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. (PubMed id 14676191)1 Brajenovic M.... Drewes G. (J. Biol. Chem. 2004)
    637. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    638. Hsp90 regulates the activity of wild type p53 under physiological and elevated temperatures. (PubMed id 15358771)1 MA1ller L....Buchner J. (J. Biol. Chem. 2004)
    639. Bisphenol A, an environmental endocrine-disrupting chemical, inhibits hypoxic response via degradation of hypoxia-inducible factor 1alpha (HIF-1alpha): structural requirement of bisphenol A for degradation of HIF-1alpha. (PubMed id 15147973)1 Kubo T....Imaoka S. (Biochem. Biophys. Res. Commun. 2004)
    640. Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein. (PubMed id 15529360)1 Quintana F.J....Cohen I.R. (Arthritis Rheum. 2004)
    641. Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. (PubMed id 15046863)1 Galigniana M.D....Pratt W.B. (Brain Res. Mol. Brain Res. 2004)
    642. PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. (PubMed id 14726529)1 Zhou J....BrA1ne B. (J. Biol. Chem. 2004)
    643. The region adjacent to the highly immunogenic site and shielded by the middle domain is responsible for self-oligomerization/client binding of the HSP90 molecular chaperone. (PubMed id 15182205)1 Nemoto T.K....Ohara-Nemoto Y. (Biochemistry 2004)
    644. The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). (PubMed id 14718169)1 Roe S.M....Pearl L.H. (Cell 2004)
    645. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. (PubMed id 15189447)1 Hatakeyama S....Nakayama K.I. (amp 2004)
    646. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PubMed id 14743216)1 Bouwmeester T....Superti-Furga G. (Nat. Cell Biol. 2004)
    647. Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. (PubMed id 15001357)1 Burch L....Hupp T.R. (J. Mol. Biol. 2004)
    648. Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. (PubMed id 15001356)1 Burch L.R....Hupp T. (J. Mol. Biol. 2004)
    649. HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. (PubMed id 15020715)1 Vendeville A....Beaumelle B. (Mol. Biol. Cell 2004)
    650. Role of the kinase MST2 in suppression of apoptosis by the proto- oncogene product Raf-1. (PubMed id 15618521)1 O'Neill E.... Kolch W. (Science 2004)
    651. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. (PubMed id 12871950)1 Suetsugu S. and Takenawa T. (J. Biol. Chem. 2003)
    652. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. (PubMed id 12526792)1 Young J.C....Hartl F.U. (Cell 2003)
    653. Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. (PubMed id 12676772)1 Venema R.C....Catravas J.D. (Am. J. Physiol. Heart Circ. Physiol. 2003)
    654. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. (PubMed id 12855682)1 Yoshida M. and Xia Y. (J. Biol. Chem. 2003)
    655. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. (PubMed id 12482853)1 Sumanasekera W.K....Perdew G.H. (J. Biol. Chem. 2003)
    656. Regulation of survivin function by Hsp90. (PubMed id 14614132)1 Fortugno P....Altieri D.C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    657. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. (PubMed id 14559896)1 Lau P.P. and Chan L. (J. Biol. Chem. 2003)
    658. Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequence. (PubMed id 12644583)1 Carystinos G.D....Batist G. (Mol. Pharmacol. 2003)
    659. Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells. (PubMed id 12821935)1 Morelli C....Surmacz E. (Oncogene 2003)
    660. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PubMed id 12852856)1 Casenghi M....Nigg E.A. (Dev. Cell 2003)
    661. Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. (PubMed id 14499622)1 Reuter T.Y....Huber P.A. (Exp. Cell Res. 2003)
    662. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. (PubMed id 12930902)1 Bermudez V.P....Hurwitz J. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    663. Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell- proliferation factor HCF-1. (PubMed id 12670868)1 Wysocka J.... Herr W. (Genes Dev. 2003)
    664. A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1 Imai Y.... Takahashi R. (J. Biol. Chem. 2003)
    665. HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo. (PubMed id 12621024)1 Hu Y. and Mivechi N.F. (J. Biol. Chem. 2003)
    666. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    667. JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells. (PubMed id 12614460)1 Jin S....Chan V.L. (Cell. Microbiol. 2003)
    668. Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. (PubMed id 11877417)1 Brinker A....Hartl F.U. (J. Biol. Chem. 2002)
    669. Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity. (PubMed id 12482202)1 Angeletti P.C....Panganiban A.T. (amp 2002)
    670. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    671. Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones. (PubMed id 12167617)1 Huang T....Stockert R.J. (J. Biol. Chem. 2002)
    672. Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. (PubMed id 12006493)1 Citri A....Yarden Y. (EMBO J. 2002)
    673. Disassembly of transcriptional regulatory complexes by molecular chaperones. (PubMed id 12077419)1 Freeman B.C. and Yamamoto K.R. (Science 2002)
    674. Insulin receptor substrate 4 associates with the protein IRAS. (PubMed id 11912194)1 Sano H.... Lienhard G.E. (J. Biol. Chem. 2002)
    675. Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. (PubMed id 12504007)1 Panaretou B....Prodromou C. (Mol. Cell 2002)
    676. Radicicol represses the transcriptional function of the estrogen receptor by suppressing the stabilization of the receptor by heat shock protein 90. (PubMed id 11911945)1 Lee M.O....Lee J.E. (Mol. Cell. Endocrinol. 2002)
    677. Native LDL and minimally oxidized LDL differentially regulate superoxide anion in vascular endothelium in situ. (PubMed id 12124224)1 Stepp D.W....Pritchard K.A. (Am. J. Physiol. Heart Circ. Physiol. 2002)
    678. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. (PubMed id 11988487)1 Fontana J....Sessa W.C. (Circ. Res. 2002)
    679. Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. (PubMed id 12221128)1 Takahashi M....Ono Y. (Mol. Biol. Cell 2002)
    680. CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. (PubMed id 12481031)1 Dias D.C.... Pan Z.Q. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    681. A structure-based mutational analysis of cyclophilin 40 identifies key residues in the core tetratricopeptide repeat domain that mediate binding to Hsp90. (PubMed id 12145316)1 Ward B.K.... Ratajczak T. (J. Biol. Chem. 2002)
    682. Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2. (PubMed id 11748628)1 SActA!lA^ G....Toran-Allerand C.D. (J. Neurobiol. 2002)
    683. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. (PubMed id 11867521)1 Wang H....Timchenko N.A. (EMBO J. 2002)
    684. Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts. (PubMed id 12117999)1 Waheed A.A. and Jones T.L. (J. Biol. Chem. 2002)
    685. Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding. (PubMed id 11284722)1 Song Y....Xia Y. (Biochem. J. 2001)
    686. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. (PubMed id 11557750)1 Jiang J....Patterson C. (J. Biol. Chem. 2001)
    687. A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135). (PubMed id 11297531)1 Akakura S....Horinouchi S. (J. Biol. Chem. 2001)
    688. Hsp90: a specialized but essential protein-folding tool. (PubMed id 11470816)1 Young J.C....Hartl F.U. (J. Cell Biol. 2001)
    689. Regulation of Pim-1 by Hsp90. (PubMed id 11237709)1 Mizuno K....Hirano T. (Biochem. Biophys. Res. Commun. 2001)
    690. Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling. (PubMed id 11598136)1 Vaiskunaite R....Voyno-Yasenetskaya T.A. (J. Biol. Chem. 2001)
    691. Proteomic and functional evidence for a P2X7 receptor signalling complex. (PubMed id 11707406)1 Kim M.... Surprenant A. (EMBO J. 2001)
    692. Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization. (PubMed id 11507088)1 Peng Y....Chen J. (J. Biol. Chem. 2001)
    693. The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. (PubMed id 11447118)1 DonzAc O....Picard D. (EMBO J. 2001)
    694. Intestinal epithelial cells secrete exosome-like vesicles. (PubMed id 11487543)1 van Niel G....Heyman M. (Gastroenterology 2001)
    695. Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. (PubMed id 11099500)1 Gisler S.M....Murer H. (J. Biol. Chem. 2001)
    696. The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. (PubMed id 11013261)1 Kazlauskas A....Pongratz I. (J. Biol. Chem. 2000)
    697. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. (PubMed id 10744744)1 Lewis J....Liu Z.G. (J. Biol. Chem. 2000)
    698. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. (PubMed id 10781589)1 Gratton J.P....Sessa W.C. (J. Biol. Chem. 2000)
    699. Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate. (PubMed id 10982807)1 Fuller W. and Cuthbert A.W. (J. Biol. Chem. 2000)
    700. Role of heat shock protein 90 in bradykinin-stimulated endothelial nitric oxide release. (PubMed id 11744239)1 Harris M.B....Venema R.C. (Gen. Pharmacol. 2000)
    701. Modulation of Akt kinase activity by binding to Hsp90. (PubMed id 10995457)1 Sato S....Tsuruo T. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    702. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    703. The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function. (PubMed id 10903152)1 Hulkko S.M....Zilliacus J. (Biochem. J. 2000)
    704. The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. (PubMed id 11076968)1 Mayor T....Nigg E.A. (J. Cell Biol. 2000)
    705. Negative regulation of the Apaf-1 apoptosome by Hsp70. (PubMed id 10934467)1 Saleh A....Alnemri E.S. (Nat. Cell Biol. 2000)
    706. The Hsp90-specific inhibitor geldanamycin selectively disrupts kinase-mediated signaling events of T-lymphocyte activation. (PubMed id 10701840)7 Schnaider T....Szamel M. (amp 2000)
    707. Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. (PubMed id 10617616)1 O'Keeffe B....Zhou Q. (J. Biol. Chem. 2000)
    708. Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity. (PubMed id 10759403)7 Neckers L....Mimnaugh E. (Invest New Drugs 1999)
    709. Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines. (PubMed id 10076566)1 Komori A....Kozu T. (Jpn. J. Cancer Res. 1999)
    710. The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association. (PubMed id 10557093)1 Nagata Y....Nakao M. (Oncogene 1999)
    711. Identification of heat shock protein 90-associated 84-kDa phosphoprotein. (PubMed id 10578053)1 Kim H.R....Kim H.D. (J. Biochem. 1999)
    712. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. (PubMed id 10409742)1 Stewart S....Guan K.L. (Mol. Cell. Biol. 1999)
    713. Hop modulates Hsp70/Hsp90 interactions in protein folding. (PubMed id 9452498)1 Johnson B.D....Toft D.O. (J. Biol. Chem. 1998)
    714. Cloning and sequence analysis of Hsp89alpha DeltaN, a new member of theHsp90 gene family. (PubMed id 9602032)1 Schweinfest C.W....Watson D.K. (Biochim. Biophys. Acta 1998)
    715. p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site. (PubMed id 9685350)1 Silverstein A.M....Pratt W.B. (J. Biol. Chem. 1998)
    716. A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. (PubMed id 9083006)1 Ma Q. and Whitlock J.P. (J. Biol. Chem. 1997)
    717. Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. (PubMed id 9111057)1 Carver L.A. and Bradfield C.A. (J. Biol. Chem. 1997)
    718. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70. (PubMed id 9261129)1 Dittmar K.D....Pratt W.B. (J. Biol. Chem. 1997)
    719. Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. (PubMed id 9020169)1 Probst M.R....Hankinson O. (J. Biol. Chem. 1997)
    720. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)1 Hogenesch J.B.... Bradfield C.A. (J. Biol. Chem. 1997)
    721. Agonist-free transformation of the glucocorticoid receptor in human B-lymphoma cells. (PubMed id 8645634)1 van den Berg J.D....van Rooij H. (J. Steroid Biochem. Mol. Biol. 1996)
    722. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. (PubMed id 7876093)1 Song H.Y.... Donner D.B. (J. Biol. Chem. 1995)
    723. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. (PubMed id 7790358)1 Golsteyn R.M....Nigg E.A. (J. Cell Biol. 1995)
    724. Evidence for a functional interaction between calmodulin and the glucocorticoid receptor. (PubMed id 7887964)1 Ning Y.M. and SA!nchez E.R. (Biochem. Biophys. Res. Commun. 1995)
    725. The calmodulin-binding domain of the mouse 90-kDa heat shock protein. (PubMed id 8486648)1 Minami Y....Yahara I. (J. Biol. Chem. 1993)
    726. Mapping the intron-containing human hsp90 alpha (HSPCAL4) gene to chromosome band 14q32. (PubMed id 8404044)1 Vamvakopoulos N.C....Jabs E.W. (Cytogenet. Cell Genet. 1993)
    727. Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system. (PubMed id 1310678)1 Hutchison K.A....Pratt W.B. (J. Biol. Chem. 1992)
    728. Association of the 90-kDa heat shock protein does not affect the ligand-binding ability of androgen receptor. (PubMed id 1525041)1 Nemoto T....Ota M. (J. Steroid Biochem. Mol. Biol. 1992)
    729. Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84). (PubMed id 1406681)1 Shaknovich R....Kohtz D.S. (Mol. Cell. Biol. 1992)
    730. Mapping of the gene family for human heat-shock protein 90 alpha to chromosomes 1, 4, 11, and 14. (PubMed id 1740332)1 Ozawa K.... Yokoyama K. (Genomics 1992)
    731. The 90 kDa heat-shock protein (hsp90) modulates the binding of the oestrogen receptor to its cognate DNA. (PubMed id 8660284)9 Sabbah M....Baulieu E.E. (Biochem. J. 1996)
    732. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. (PubMed id 14508491)9 Kamal A....Burrows F.J. (Nature 2003)
    733. Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates sensitivity to the Hsp90 inhibitor radicicol. (PubMed id 17681020)9 Millson S.H....Piper P.W. (FEBS J. 2007)
    734. Identification of antibodies to heat shock proteins 90 kDa and 70 kDa in patients with schizophrenia. (PubMed id 11595400)9 Kim J.J....Paik I.H. (Schizophr. Res. 2001)
    735. Using natural product inhibitors to validate Hsp90 as a molecular target in cancer. (PubMed id 16842153)9 Neckers L. (Curr Top Med Chem 2006)
    736. Calmodulin-dependent and -independent activation of endothelial nitric-oxide synthase by heat shock protein 90. (PubMed id 12519764)9 Takahashi S. and Mendelsohn M.E. (J. Biol. Chem. 2003)
    737. [Molecular chaperone HSP90 as a novel target for cancer chemotherapy]. (PubMed id 12617036)9 Miyata Y. (Nippon Yakurigaku Zasshi 2003)
    738. New developments in Hsp90 inhibitors as anti-cancer therapeutics: mechanisms, clinical perspective and more potential. (PubMed id 19179103)9 Li Y....Sun D. (Drug Resist. Updat. 2009)
    739. Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. (PubMed id 19642705)9 Peng H.M....Osawa Y. (Biochemistry 2009)
    740. Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors. (PubMed id 18931700)9 Smith J.R....Workman P. (Oncogene 2009)
    741. High HSP90 expression is associated with decreased survival in breast cancer. (PubMed id 17409397)9 Pick E....Kluger H.M. (Cancer Res. 2007)
    742. Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1). (PubMed id 16100115)9 Song Y. and Masison D.C. (J. Biol. Chem. 2005)
    743. Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions. (PubMed id 15209518)9 Yun B.G....Matts R.L. (Biochemistry 2004)
    744. Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries. (PubMed id 12780528)9 Elpek G.O....Aksoy N.H. (APMIS 2003)
    745. Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. (PubMed id 12820659)9 David C.L....Whitesell L. (amp 2003)
    746. Coordinated ATP hydrolysis by the Hsp90 dimer. (PubMed id 11441008)9 Richter K....Buchner J. (J. Biol. Chem. 2001)
    747. Role of HSP90 in mediating cross-talk between the estrogen receptor and the Ah receptor signal transduction pathways. (PubMed id 10513983)9 Caruso J.A....Batist G. (Biochem. Pharmacol. 1999)
    748. Steroid receptor interactions with heat shock protein and immunophilin chaperones. (PubMed id 9183567)9 Pratt W.B. and Toft D.O. (Endocr. Rev. 1997)
    749. Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death. (PubMed id 19014912)9 Beck R....Calderon P.B. (Biochem. Pharmacol. 2009)
    750. (-)-Epigallocatechin-3-gallate inhibits Hsp90 function by impairing Hsp90 association with cochaperones in pancreatic cancer cell line Mia Paca-2. (PubMed id 19438225)9 Li Y....Sun D. (Mol. Pharm. 2009)
    751. Expression of heat shock protein 90 (Hsp90) and transcription of its corresponding mRNA in broilers exposed to high temperature. (PubMed id 19735020)9 Lei L....Bao E. (Br. Poult. Sci. 2009)
    752. Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization. (PubMed id 16421106)9 Allan R.K....Ratajczak T. (J. Biol. Chem. 2006)
    753. Hsp90: a novel target for cancer therapy. (PubMed id 16842157)9 Solit D.B. and Rosen N. (Curr Top Med Chem 2006)
    754. Overview: translating Hsp90 biology into Hsp90 drugs. (PubMed id 14529382)9 Workman P. (Curr Cancer Drug Targets 2003)
    755. C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. (PubMed id 12611898)9 Cheung-Flynn J....Smith D.F. (J. Biol. Chem. 2003)
    756. Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. (PubMed id 12842893)9 Sreedhar A.S....Csermely P. (J. Biol. Chem. 2003)
    757. Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. (PubMed id 12678776)9 Neckers L. (Curr. Med. Chem. 2003)
    758. Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. (PubMed id 12527207)9 Piper P.W....Prodromou C. (Gene 2003)
    759. The molecular chaperone Hsp90 can negatively regulate the activity of a glucocorticosteroid-dependent promoter. (PubMed id 9990042)9 Kang K.I....Catelli M.G. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    760. Molybdate inhibits hsp90, induces structural changes in its C-terminal domain, and alters its interactions with substrates. (PubMed id 10090774)9 Hartson S.D....Matts R.L. (Biochemistry 1999)
    761. Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models. (PubMed id 20015528)9 Hackl C....Stoeltzing O. (Surgery 2010)
    762. Structural and computational biology of the molecular chaperone Hsp90: from understanding molecular mechanisms to computer-based inhibitor design. (PubMed id 19860735)9 Verkhivker G.M....Colombo G. (Curr Top Med Chem 2009)
    763. (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor. (PubMed id 19113837)9 Yin Z....Gasiewicz T.A. (Biochemistry 2009)
    764. A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion. (PubMed id 17968312)9 Tsutsumi S....Neckers L. (Oncogene 2008)
    765. A conformational switch in the ligand-binding domain regulates the dependence of the glucocorticoid receptor on Hsp90. (PubMed id 17367809)9 Ricketson D....Darimont B.D. (J. Mol. Biol. 2007)
    766. Nitric oxide and superoxide generation from endothelial NOS: modulation by HSP90. (PubMed id 17827253)9 Sud N....Black S.M. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    767. HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis. (PubMed id 16328963)9 Zhang M.H....Seo J.S. (Mol. Cell. Biochem. 2006)
    768. Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import. (PubMed id 16968702)9 Fan A.C....Young J.C. (J. Biol. Chem. 2006)
    769. A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues. (PubMed id 16684877)9 Gooljarsingh L.T....Tummino P.J. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    770. Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. (PubMed id 16385472)9 Blagg B.S. and Kerr T.D. (Med Res Rev 2006)
    771. Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines. (PubMed id 16283383)9 Senju M....Sueoka E. (J. Cancer Res. Clin. Oncol. 2006)
    772. Effectiveness of hsp90 inhibitors as anti-cancer drugs. (PubMed id 17073714)9 Xiao L....Ruden D.M. (Mini Rev Med Chem 2006)
    773. Control of canalization and evolvability by Hsp90. (PubMed id 17183707)9 Milton C.C....Rutherford S. (PLoS ONE 2006)
    774. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. (PubMed id 15671027)9 Peng X....Sawyer D.B. (J. Biol. Chem. 2005)
    775. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. (PubMed id 15853661)9 Miyata Y. (Curr. Pharm. Des. 2005)
    776. Heat-induced degradation of overexpressed glucocorticoid receptor Separate protective roles of hsp90 and hsp70. (PubMed id 15862954)9 Siriani D....Alexis M.N. (J. Steroid Biochem. Mol. Biol. 2005)
    777. Exposure of protein kinase motifs that trigger binding of Hsp90 and Cdc37. (PubMed id 16269130)9 Prince T. and Matts R.L. (Biochem. Biophys. Res. Commun. 2005)
    778. Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin. (PubMed id 15271357)9 Lee Y.S....Neckers L. (amp 2004)
    779. Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kappaB and AP-1. (PubMed id 14967193)9 Tago K....Takano K. (Life Sci. 2004)
    780. Expression of heat-shock protein Hsp60 correlated with the apoptotic index and patient prognosis in human oesophageal squamous cell carcinoma. (PubMed id 15571964)9 Faried A....Kuwano H. (Eur. J. Cancer 2004)
    781. Structure and functional relationships of Hsp90. (PubMed id 14529383)9 Prodromou C. and Pearl L.H. (Curr Cancer Drug Targets 2003)
    782. Evidence that the novobiocin-sensitive ATP-binding site of the heat shock protein 90 (hsp90) is necessary for its autophosphorylation. (PubMed id 12127946)9 Langer T....Fasold H. (Cell Biol. Int. 2002)
    783. Purification and characterization of porcine testis 90-kDa heat shock protein (HSP90) as a substrate for various protein kinases. (PubMed id 11934275)9 Huang H.C....Lee W.C. (J. Protein Chem. 2002)
    784. Hydrodynamic properties and quaternary structure of the 90 kDa heat-shock protein: effects of divalent cations. (PubMed id 12269819)9 Garnier C....Peyrot V. (Biochemistry 2002)
    785. Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck). (PubMed id 10793137)9 Bijlmakers M.J. and Marsh M. (Mol. Biol. Cell 2000)
    786. C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle. (PubMed id 11054293)9 Weikl T....Buchner J. (J. Mol. Biol. 2000)
    787. p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules. (PubMed id 10858314)9 Hartson S.D....Matts R.L. (Biochemistry 2000)
    788. Heat-induced chaperone activity of HSP90. (PubMed id 8576234)9 Yonehara M....Yahara I. (J. Biol. Chem. 1996)
    789. A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta. (PubMed id 20138026)9 Millson S.H....Piper P.W. (Biochem. Pharmacol. 2010)
    790. Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells. (PubMed id 20398291)9 Cheung C.H....Chang J.Y. (Mol. Cancer 2010)
    791. Hsp90: a drug target? (PubMed id 20425593)9 Holzbeierlein J.M....Vielhauer G. (Curr Oncol Rep 2010)
    792. Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma. (PubMed id 19441108)9 Breinig M....Kern M.A. (Hepatology 2009)
    793. The Hsp90 chaperone machinery: from structure to drug development. (PubMed id 19874705)9 Hahn J.S. (BMB Rep 2009)
    794. HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy. (PubMed id 19689285)9 Hwang M....Lu B. (Curr. Med. Chem. 2009)
    795. Trithorax requires Hsp90 for maintenance of active chromatin at sites of gene expression. (PubMed id 19144915)9 Tariq M....Paro R. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    796. 17 AAG for HSP90 inhibition in cancer--from bench to bedside. (PubMed id 19601813)9 Usmani S.Z....Li Z. (Curr. Mol. Med. 2009)
    797. Dicoumarol down-regulates human PTTG1/Securin mRNA expression through inhibition of Hsp90. (PubMed id 18347135)9 HernA!ndez A....Pintor-Toro J.A. (Mol. Cancer Ther. 2008)
    798. Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. (PubMed id 18347186)9 Cao X....Sun D. (Clin. Cancer Res. 2008)
    799. Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy. (PubMed id 17891170)9 Nieto-Miguel T....Mollinedo F. (Oncogene 2008)
    800. Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs. (PubMed id 17266581)9 Xiao L....Ruden D.M. (Curr. Med. Chem. 2007)
    801. Definition of the minimal fragments of Sti1 required for dimerization, interaction with Hsp70 and Hsp90 and in vivo functions. (PubMed id 17300223)9 Flom G....Johnson J.L. (Biochem. J. 2007)
    802. Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. (PubMed id 17662999)9 Onuoha S.C....Jackson S.E. (J. Mol. Biol. 2007)
    803. Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress. (PubMed id 17513464)9 Workman P....Rosen N. (Ann. N. Y. Acad. Sci. 2007)
    804. Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90. (PubMed id 16289154)9 Picard D. (Exp. Cell Res. 2006)
    805. The expression of molecular chaperone HSP90 and IL-6 in patients with systemic lupus erythematosus. (PubMed id 17357483)9 Hu S....Huang M. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2006)
    806. Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37. (PubMed id 15258137)9 Prince T. and Matts R.L. (J. Biol. Chem. 2004)
    807. Hsp90 enhances degradation of oxidized calmodulin by the 20 S proteasome. (PubMed id 15319444)9 Whittier J.E....Squier T.C. (J. Biol. Chem. 2004)
    808. Targeting multiple signal transduction pathways through inhibition of Hsp90. (PubMed id 15168026)9 Zhang H. and Burrows F. (J. Mol. Med. 2004)
    809. Heat shock protein 90. (PubMed id 14624223)9 Neckers L. and Ivy S.P. (Curr Opin Oncol 2003)
    810. Interaction of neuropeptide Y and Hsp90 through a novel peptide binding region. (PubMed id 14596612)9 Ishiwatari-Hayasaka H....Yahara I. (Biochemistry 2003)
    811. Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy. (PubMed id 11698240)9 Song Y....Xia Y. (Am. J. Physiol., Cell Physiol. 2001)
    812. Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. (PubMed id 11438552)9 Zhao Y.G....Lee P.W. (J. Biol. Chem. 2001)
    813. Heat shock protein 90 in retinal ganglion cells: association with axonally transported proteins. (PubMed id 11497419)9 Bernstein S.L....Smith L.E. (Vis. Neurosci. 2001)
    814. Hsp90 chaperone activity requires the full-length protein and interaction among its multiple domains. (PubMed id 10913439)9 Johnson B.D....Toft D.O. (J. Biol. Chem. 2000)
    815. Heat-induced oligomerization of the molecular chaperone Hsp90. Inhibition by ATP and geldanamycin and activation by transition metal oxyanions. (PubMed id 9933607)9 Chadli A....Catelli M.G. (J. Biol. Chem. 1999)
    816. Hsp90 is required for pheromone signaling in yeast. (PubMed id 9802897)9 Louvion J.F....Picard D. (Mol. Biol. Cell 1998)
    817. Selective interaction of hsp90 with an estrogen receptor ligand-binding domain containing a point mutation. (PubMed id 9115298)9 Aumais J.P....White J.H. (J. Biol. Chem. 1997)
    818. Analysis of the native forms of the 90 kDa heat shock protein (hsp90) in plant cytosolic extracts. (PubMed id 9049266)9 Krishna P....Felsheim R.F. (Plant Mol. Biol. 1997)
    819. Structural organization of procaryotic and eucaryotic Hsp90. Influence of divalent cations on structure and function. (PubMed id 7782303)9 Jakob U....Buchner J. (J. Biol. Chem. 1995)
    820. The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity. (PubMed id 1551911)9 Miyata Y. and Yahara I. (J. Biol. Chem. 1992)
    821. Different immunoelectron microscopic locations of progesterone receptor and HSP90 in chick oviduct epithelial cells. (PubMed id 1856457)9 Pekki A.K. (J. Histochem. Cytochem. 1991)
    822. An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors. (PubMed id 19747088)9 Dakappagari N....Zhang H. (Biomarkers 2010)
    823. Mitochondrial carrier protein biogenesis: role of the chaperones Hsc70 and Hsp90. (PubMed id 19143589)9 Zara V....Young J.C. (Biochem. J. 2009)
    824. Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. (PubMed id 18418733)9 Duncan R.F. (amp 2008)
    825. Role of the cochaperone Tpr2 in Hsp90 chaperoning. (PubMed id 18620420)9 Moffatt N.S.... Toft D. (Biochemistry 2008)
    826. Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis. (PubMed id 17922836)9 Miyata Y. and Nishida E. (FEBS J. 2007)
    827. 2-color photobleaching experiments reveal distinct intracellular dynamics of two components of the Hsp90 complex. (PubMed id 17010336)9 Picard D....Briand P.A. (Exp. Cell Res. 2006)
    828. Chaperoning oncogenes: Hsp90 as a target of geldanamycin. (PubMed id 16610363)9 Neckers L. (Handb Exp Pharmacol 2006)
    829. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. (PubMed id 16452239)9 Zaarur N....Sherman M.Y. (Cancer Res. 2006)
    830. CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone. (PubMed id 16335536)9 Miyata Y. and Nishida E. (Mol. Cell. Biochem. 2005)
    831. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. (PubMed id 15841378)9 Smith V....Burger A.M. (Cancer Chemother. Pharmacol. 2005)
    832. Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein. (PubMed id 12684036)9 Tanioka T....Kudo I. (Biochem. Biophys. Res. Commun. 2003)
    833. Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors. (PubMed id 12869560)9 Adinolfi E....Surprenant A. (J. Biol. Chem. 2003)
    834. Inhibition of heat shock protein 90 (hsp90) in proliferating endothelial cells uncouples endothelial nitric oxide synthase activity. (PubMed id 12521608)9 Ou J....Pritchard K.A. (amp 2003)
    835. Serum IgG to heat shock proteins and Porphyromonas gingivalis antigens in diabetic patients with periodontitis. (PubMed id 12296783)9 Sims T.J....Persson G.R. (J. Clin. Periodontol. 2002)
    836. Heat shock protects HCT116 and H460 cells from TRAIL-induced apoptosis. (PubMed id 12460647)9 OzAPren N. and El-Deiry W. (Exp. Cell Res. 2002)
    837. [The effects of heat shock protein 90 and glucocorticoid receptor on apoptosis in T lymphocytes from asthmatic patients]. (PubMed id 16200774)9 Qian X....Xu W. (Zhonghua Yi Xue Za Zhi 2001)
    838. Glucocorticoid receptor and heat shock protein 90 in peripheral blood mononuclear cells from asthmatics. (PubMed id 11677765)9 Qian X....Lin Y. (Chin. Med. J. 2001)
    839. Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23. (PubMed id 11060043)9 Young J.C. and Hartl F.U. (EMBO J. 2000)
    840. Cdc37 is a molecular chaperone with specific functions in signal transduction. (PubMed id 9242486)9 Kimura Y....Lindquist S. (amp 1997)
    841. Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression. (PubMed id 8625242)9 Nanbu K....Mori T. (Cancer 1996)
    842. Recombinant Leishmania Hsp90 and Hsp70 are recognized by sera from visceral leishmaniasis patients but not Chagas' disease patients. (PubMed id 1537901)9 de Andrade C.R....Otsu K. (J. Clin. Microbiol. 1992)
    843. Death by chaperone: HSP90, HSP70 or both? (PubMed id 19197160)9 Powers M.V....Workman P. (Cell Cycle 2009)
    844. Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. (PubMed id 19194158)9 Amour J....Kersten J.R. (Anesthesiology 2009)
    845. Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G2/M cell cycle arrest and apoptosis. (PubMed id 19082595)9 Watanabe G....Kim R.D. (Cancer Chemother. Pharmacol. 2009)
    846. The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy. (PubMed id 19073599)9 Sreeramulu S....Schwalbe H. (J. Biol. Chem. 2009)
    847. Low concentration of GA activates a preconditioning response in HepG2 cells during oxidative stress-roles of Hsp90 and vimentin. (PubMed id 19137416)9 Chen X....Zou F. (amp 2009)
    848. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. (PubMed id 19229106)9 Kang B.H....Altieri D.C. (J. Clin. Invest. 2009)
    849. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. (PubMed id 19091746)9 Gould C.M....Newton A.C. (J. Biol. Chem. 2009)
    850. Cisplatin differently affects amino terminal and carboxyl terminal domains of HSP90. (PubMed id 18955054)9 Ishida R....Itoh H. (FEBS Lett. 2008)
    851. HIF-1alpha and STAT3 client proteins interacting with the cancer chaperone Hsp90: therapeutic considerations. (PubMed id 18347418)9 Kim H.L....Vogiatzi P. (amp 2008)
    852. NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models. (PubMed id 18430202)9 Jensen M.R....ChA"ne P. (Breast Cancer Res. 2008)
    853. The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. (PubMed id 18440021)9 Guarnieri M.T....Zhao R. (J. Mol. Biol. 2008)
    854. Inhibition of Hsp90: a multitarget approach to radiosensitization. (PubMed id 17671112)9 Camphausen K. and Tofilon P.J. (Clin. Cancer Res. 2007)
    855. Functional coevolutionary networks of the Hsp70-Hop-Hsp90 system revealed through computational analyses. (PubMed id 17267421)9 Travers S.A. and Fares M.A. (Mol. Biol. Evol. 2007)
    856. Importance of the C-terminal domain of harc for binding to hsp70 and hop as well as its response to heat shock. (PubMed id 18052042)9 Cartledge K.... Scholz G.M. (Biochemistry 2007)
    857. Heat shock protein expression in canine malignant mammary tumours. (PubMed id 16803633)9 Romanucci M....Della Salda L. (BMC Cancer 2006)
    858. Domain:domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure. (PubMed id 16452615)9 Carrigan P.E....Ramirez-Alvarado M. (Protein Sci. 2006)
    859. Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives. (PubMed id 16634649)9 Maroney A.C....Johnson D.L. (Biochemistry 2006)
    860. Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts. (PubMed id 15338192)9 Eiseman J.L....Egorin M.J. (Cancer Chemother. Pharmacol. 2005)
    861. Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. (PubMed id 16170022)9 Chen L....Wu J. (Mol. Cancer Ther. 2005)
    862. Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. (PubMed id 15810071)9 Lim S.O....Park C.K. (World J. Gastroenterol. 2005)
    863. Hsp70 and Hsp90--a relay team for protein folding. (PubMed id 14740253)9 Wegele H....Buchner J. (Rev. Physiol. Biochem. Pharmacol. 2004)
    864. Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma. (PubMed id 12942564)9 Lebret T....Botto H. (Cancer 2003)
    865. Antibodies to HSP70 and HSP90 in serum in non-small cell lung cancer patients. (PubMed id 12893076)9 Zhong L....Hirschowitz E.A. (Cancer Detect. Prev. 2003)
    866. Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase. (PubMed id 12022881)9 Shao J....Matts R.L. (Biochemistry 2002)
    867. Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. (PubMed id 10764743)9 Morishima Y....Pratt W.B. (J. Biol. Chem. 2000)
    868. The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes. (PubMed id 10364185)9 Grenert J.P....Toft D.O. (J. Biol. Chem. 1999)
    869. [Functional interaction of HSP90 with steroid receptors]. (PubMed id 10689618)9 Catelli M.G....Cadepond F. (J. Soc. Biol. 1999)
    870. An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function. (PubMed id 10543959)9 Weikl T....Buchner J. (J. Mol. Biol. 1999)
    871. HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes. (PubMed id 9710578)9 Ali A....Ovsenek N. (Mol. Cell. Biol. 1998)
    872. ATP-binding properties of human Hsp90. (PubMed id 9228028)9 Scheibel T....Buchner J. (J. Biol. Chem. 1997)
    873. The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. (PubMed id 8670798)9 Freeman B.C. and Morimoto R.I. (EMBO J. 1996)
    874. Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding. (PubMed id 8621687)9 Ratajczak T. and Carrello A. (J. Biol. Chem. 1996)
    875. ATP induces dissociation of the 90 kDa heat shock protein (hsp90) from F-actin: interference with the binding of heavy meromyosin. (PubMed id 7779083)9 Kellermayer M.S. and Csermely P. (Biochem. Biophys. Res. Commun. 1995)
    876. Heat shock protein expression in human conjunctiva. (PubMed id 8112980)9 Berra A....Foster C.S. (amp 1994)
    877. Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. (PubMed id 8117717)9 Nadeau K....Walsh C.T. (Biochemistry 1994)
    878. Chromatographic separation of eight progesterone receptor isoforms in human breast tumors, and detection by radioligand and monoclonal antibodies. Association with hsp90 and hsp70 heat shock proteins. (PubMed id 7856945)9 Lemoisson E....Goussard J. (Ann. Biol. Clin. (Paris) 1994)
    879. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. (PubMed id 8423808)9 Smith D.F....Toft D.O. (Mol. Cell. Biol. 1993)
    880. Hsp90 as a therapeutic target in patients with oesophageal carcinoma. (PubMed id 20148718)9 Ekman S....Lennartsson J. (Expert Opin. Ther. Targets 2010)
    881. The Hsp90 co-chaperone p23 of Toxoplasma gondii: Identification, functional analysis and dynamic interactome determination. (PubMed id 20403389)9 Echeverria P.C....Angel S.O. (Mol. Biochem. Parasitol. 2010)
    882. Dual role of heat shock proteins as regulators of apoptosis and innate immunity. (PubMed id 20375559)9 Joly A.L....Garrido C. (J Innate Immun 2010)
    883. Tamoxifen enhances the Hsp90 molecular chaperone ATPase activity. (PubMed id 20376192)9 Zhao R....Houry W.A. (PLoS ONE 2010)
    884. Hsp90 inhibitors as promising agents for radiotherapy. (PubMed id 19946660)9 Kabakov A.E....Gabai V.L. (J. Mol. Med. 2010)
    885. Modulation of Hsf1 activity by novobiocin and geldanamycin. (PubMed id 19935870)9 Conde R....Ovsenek N. (Biochem. Cell Biol. 2009)
    886. Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. (PubMed id 19586912)9 Kajander T....Regan L. (J. Biol. Chem. 2009)
    887. Targeting CDC37: an alternative, kinase-directed strategy for disruption of oncogenic chaperoning. (PubMed id 19177013)9 Smith J.R. and Workman P. (Cell Cycle 2009)
    888. Hsp70 molecular chaperones are required to support p53 tumor suppressor activity under stress conditions. (PubMed id 19749793)9 Walerych D....Zylicz A. (Oncogene 2009)
    889. Expression of heat shock proteins and nitrotyrosine in small arteries from patients with coronary heart disease. (PubMed id 19626397)9 Paier A....Kublickiene K. (Heart Vessels 2009)
    890. Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice. (PubMed id 19085954)9 Lang S.A....Stoeltzing O. (Hepatology 2009)
    891. C-terminal sequences of hsp70 and hsp90 as non-specific anchors for tetratricopeptide repeat (TPR) proteins. (PubMed id 19689428)9 Ramsey A.J....Chinkers M. (Biochem. J. 2009)
    892. The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90. (PubMed id 18726985)9 Aalinkeel R....Schwartz S.A. (Prostate 2008)
    893. Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. (PubMed id 18840695)9 Yano A....Neckers L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    894. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. (PubMed id 18772114)9 Powers M.V....Workman P. (Cancer Cell 2008)
    895. 4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. (PubMed id 18020435)9 Brough P.A....Wright L. (J. Med. Chem. 2008)
    896. Chaperone-dependent stabilization and degradation of p53 mutants. (PubMed id 18223694)9 Muller P....Vojtesek B. (Oncogene 2008)
    897. Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei. (PubMed id 18193284)9 Jones C....Chaudhuri M. (Parasitol. Res. 2008)
    898. Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90. (PubMed id 18282612)9 Salminen A....Kaarniranta K. (Immunol. Lett. 2008)
    899. Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. (PubMed id 18089825)9 Gray P.J....Calderwood S.K. (Cancer Res. 2007)
    900. Bcr-Abl-independent imatinib-resistant K562 cells show aberrant protein acetylation and increased sensitivity to histone deacetylase inhibitors. (PubMed id 17569822)9 Lee S.M....Kim S.H. (J. Pharmacol. Exp. Ther. 2007)
    901. Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. (PubMed id 17525289)9 Davenport E.L....Davies F.E. (Blood 2007)
    902. Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. (PubMed id 17804463)9 Stahl M....Beck J. (Nucleic Acids Res. 2007)
    903. Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1. (PubMed id 17688194)9 Taylor D.M....Durham H.D. (amp 2007)
    904. Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines. (PubMed id 17487411)9 HAYvik B. and Bramham C.R. (Oncol. Rep. 2007)
    905. Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. (PubMed id 17382893)9 Dey A. and Cederbaum A.I. (Arch. Biochem. Biophys. 2007)
    906. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. (PubMed id 17363505)9 Lang S.A....Stoeltzing O. (Mol. Cancer Ther. 2007)
    907. Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo. (PubMed id 18025273)9 Moser C....Stoeltzing O. (Mol. Cancer Ther. 2007)
    908. Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade. (PubMed id 16966435)9 Mimnaugh E.G....Neckers L. (Mol. Cancer Res. 2006)
    909. Sperm sorting procedure induces a redistribution of Hsp70 but not Hsp60 and Hsp90 in boar spermatozoa. (PubMed id 16870948)9 Spinaci M....Galeati G. (J. Androl. 2006)
    910. Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. (PubMed id 16551874)9 Srirangam A....Potter D.A. (Clin. Cancer Res. 2006)
    911. Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain. (PubMed id 17130446)9 Fang L....Darimont B. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    912. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. (PubMed id 17090671)9 Sydor J.R....Tong J.K. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    913. Substrate transfer from the chaperone Hsp70 to Hsp90. (PubMed id 16403523)9 Wegele H....Buchner J. (J. Mol. Biol. 2006)
    914. Alleviating neurodegeneration by an anticancer agent: an Hsp90 inhibitor (17-AAG). (PubMed id 17185503)9 Waza M....Sobue G. (Ann. N. Y. Acad. Sci. 2006)
    915. Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers. (PubMed id 15867239)9 Ramanathan R.K....Egorin M.J. (Clin. Cancer Res. 2005)
    916. Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. (PubMed id 15455381)9 Bagatell R....Whitesell L. (Int. J. Cancer 2005)
    917. Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues. (PubMed id 15884943)9 Moulin E....Winssinger N. (J. Am. Chem. Soc. 2005)
    918. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. (PubMed id 15922741)9 Yun B.G. and Matts R.L. (Exp. Cell Res. 2005)
    919. Alpha-synuclein and chaperones in dementia with Lewy bodies. (PubMed id 16319716)9 Cantuti-Castelvetri I....Standaert D.G. (J. Neuropathol. Exp. Neurol. 2005)
    920. Hsp90 and Cdc37 -- a chaperone cancer conspiracy. (PubMed id 15661534)9 Pearl L.H. (amp 2005)
    921. Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway. (PubMed id 14764593)9 Isaacs J.S....Neckers L. (J. Biol. Chem. 2004)
    922. 17-(Allylamino)-17-demethoxygeldanamycin activity in human melanoma models. (PubMed id 15057143)9 Burger A.M....Sausville E.A. (Anticancer Drugs 2004)
    923. Heat-shock protein 70 and heat-shock protein 90 associate with Toll-like receptor 4 in response to bacterial lipopolysaccharide. (PubMed id 15270695)9 Triantafilou M. and Triantafilou K. (Biochem. Soc. Trans. 2004)
    924. Translational regulation of Hsp90 mRNA. AUG-proximal 5'-untranslated region elements essential for preferential heat shock translation. (PubMed id 15347681)9 Ahmed R. and Duncan R.F. (J. Biol. Chem. 2004)
    925. Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90. (PubMed id 15217612)9 Vilenchik M....Chiosis G. (amp 2004)
    926. Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90. (PubMed id 14987994)9 Wochnik G.M....Rein T. (FEBS Lett. 2004)
    927. [Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]. (PubMed id 15132902)9 Bai X.X....Wang W.D. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2003)
    928. Hsp90 as a therapeutic target in prostate cancer. (PubMed id 14571418)9 Solit D.B....Rosen N. (Semin. Oncol. 2003)
    929. Effects of heat stress and mechanical stretch on protein expression in cultured skeletal muscle cells. (PubMed id 14534791)9 Goto K....Yoshioka T. (Pflugers Arch. 2003)
    930. Magnetic resonance spectroscopic pharmacodynamic markers of the heat shock protein 90 inhibitor 17-allylamino,17-demethoxygeldanamycin (17AAG) in human colon cancer models. (PubMed id 14600095)9 Chung Y.L....Ronen S.M. (J. Natl. Cancer Inst. 2003)
    931. Functional dissection of cdc37: characterization of domain structure and amino acid residues critical for protein kinase binding. (PubMed id 14580204)9 Shao J....Matts R.L. (Biochemistry 2003)
    932. Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. (PubMed id 12755697)9 Soti C....Csermely P. (Eur. J. Biochem. 2003)
    933. The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. (PubMed id 12869591)9 Rosenhagen M.C....Rein T. (Mol. Endocrinol. 2003)
    934. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. (PubMed id 12563018)9 Pratt W.B. and Toft D.O. (Exp. Biol. Med. (Maywood) 2003)
    935. Mechanism of simvastatin on induction of heat shock protein in osteoblasts. (PubMed id 12801507)9 Wang X....Kozawa O. (Arch. Biochem. Biophys. 2003)
    936. T cells and autoantibodies to human HSP70 in type 1 diabetes in children. (PubMed id 12791317)9 Abulafia-Lapid R....Cohen I.R. (J. Autoimmun. 2003)
    937. The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin. (PubMed id 14514358)9 Kumar R....Barik S. (Malar. J. 2003)
    938. Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation. (PubMed id 14713575)9 Machida H....Kubota N. (Int. J. Radiat. Biol. 2003)
    939. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. (PubMed id 12213383)9 Petrulis J.R. and Perdew G.H. (Chem. Biol. Interact. 2002)
    940. Characterization of proteins associated with heat shock protein hsp27 in the squamous cell carcinoma cell line A431. (PubMed id 11779227)9 Kindas-MA1gge I....Riedler C. (Cell Biol. Int. 2002)
    941. Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone. (PubMed id 12507224)9 Workman P. (Cancer Detect. Prev. 2002)
    942. HSP70 and HSP90 expression in leucocytes after exercise in moderately trained humans. (PubMed id 12028134)9 Shastry S....Joyner M.J. (Acta Physiol. Scand. 2002)
    943. N-terminal residues regulate the catalytic efficiency of the Hsp90 ATPase cycle. (PubMed id 12235160)9 Richter K....Buchner J. (J. Biol. Chem. 2002)
    944. Heat shock protein 70 and heat shock protein 90 expression in light- and dark-adapted adult octopus retinas. (PubMed id 12815237)9 Ochoa G.H....Robles L.J. (J. Neurocytol. 2002)
    945. The receptor for heat shock protein 60 on macrophages is saturable, specific, and distinct from receptors for other heat shock proteins. (PubMed id 11777948)9 Habich C....Burkart V. (J. Immunol. 2002)
    946. Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors. (PubMed id 12145695)9 Minami Y....Naoe T. (Leukemia 2002)
    947. Fluorescence recovery after photobleaching reveals that LPS rapidly transfers from CD14 to hsp70 and hsp90 on the cell membrane. (PubMed id 11559761)9 Triantafilou K....Cherry R. (J. Cell. Sci. 2001)
    948. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. (PubMed id 11701613)9 Brouet A....Feron O. (Circ. Res. 2001)
    949. Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes. (PubMed id 11170435)9 Morishima Y....Pratt W.B. (Biochemistry 2001)
    950. Expression and functional activity of heat shock proteins in human glioblastoma multiforme. (PubMed id 10746610)9 Hermisson M....Weller M. (Neurology 2000)
    951. [Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases]. (PubMed id 10891711)9 Vanmuylder N....Dourov N. (Ann Pathol 2000)
    952. Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cells. (PubMed id 10946285)9 Binder R.J....Srivastava P.K. (J. Immunol. 2000)
    953. Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. I. Evidence for allosteric regulation of ligand binding. (PubMed id 10816561)9 Rosser M.F. and Nicchitta C.V. (J. Biol. Chem. 2000)
    954. Chaperones in the parotid gland: localization of heat shock proteins in human adult salivary glands. (PubMed id 10971043)9 Vanmuylder N....Dourov N. (Cells Tissues Organs (Print) 2000)
    955. Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90. (PubMed id 11050175)9 Chadli A....Toft D.O. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    956. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. (PubMed id 10702249)9 Morishima Y....Pratt W.B. (J. Biol. Chem. 2000)
    957. A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and trans-activation potential. (PubMed id 11093792)9 Levine S.L....Perdew G.H. (Mol. Pharmacol. 2000)
    958. Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. (PubMed id 10632574)9 Kim H.R....Kim H.D. (IUBMB Life 1999)
    959. Transcriptional regulation of the heat shock protein genes by STAT family transcription factors. (PubMed id 10440232)9 Stephanou A. and Latchman D.S. (Gene Expr. 1999)
    960. Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein. (PubMed id 10601253)9 Silverstein A.M....Pratt W.B. (J. Biol. Chem. 1999)
    961. Heat shock proteins and heat shock protein-antibody complexes in placental tissues. (PubMed id 10449265)9 Ziegert M....HAortig W. (Infect Dis Obstet Gynecol 1999)
    962. Interaction of vanadate oligomers and permolybdate with the 90-kDa heat-shock protein, Hsp90. (PubMed id 9738900)9 SAPti C....Csermely P. (Eur. J. Biochem. 1998)
    963. Geldanamycin, an hsp90/GRP94-binding drug, induces increased transcription of endoplasmic reticulum (ER) chaperones via the ER stress pathway. (PubMed id 9428803)9 Lawson B....Hendershot L.M. (J. Cell. Physiol. 1998)
    964. Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol. (PubMed id 9632140)9 Sharma S.V....Nakano H. (Oncogene 1998)
    965. Luciferase activity and synthesis of Hsp70 and Hsp90 are insensitive to 50Hz electromagnetic fields. (PubMed id 9718073)9 Kang K.I....Catelli M.G. (Life Sci. 1998)
    966. Characterization of human proximal tubular cells after hypoxic preconditioning: constitutive and hypoxia-induced expression of heat shock proteins HSP70 (A, B, and C), HSC70, and HSP90. (PubMed id 9066981)9 Turman M.A....Bates C.M. (Biochem. Mol. Med. 1997)
    967. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover. (PubMed id 9390191)9 Chen H.S....Perdew G.H. (Arch. Biochem. Biophys. 1997)
    968. HSP70 and HSP90 homologs are associated with tubulin in hetero-oligomeric complexes, cilia and the cortex of Tetrahymena. (PubMed id 9247200)9 Williams N.E. and Nelsen E.M. (J. Cell. Sci. 1997)
    969. Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology. (PubMed id 8892646)9 Galea-Lauri J....Katz D.R. (J. Immunol. 1996)
    970. Differential expression and regulation of hsp70 and hsp90 by phorbol esters and heat shock. (PubMed id 7775471)9 Jacquier-Sarlin M.R....Polla B.S. (J. Biol. Chem. 1995)
    971. Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells. (PubMed id 8523429)9 Heads R.J....Latchman D.S. (J. Mol. Cell. Cardiol. 1995)
    972. Multiple p53 protein isoforms and formation of oligomeric complexes with heat shock proteins Hsp70 and Hsp90 in the human mammary tumor, T47D, cell line. (PubMed id 7811761)9 Selkirk J.K....He C. (Appl. Theor. Electrophor. 1994)
    973. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70. (PubMed id 8189059)9 Udono H. and Srivastava P.K. (J. Immunol. 1994)
    974. Hsc70, immunoglobulin heavy chain binding protein, and Hsp90 differ in their ability to stimulate transport of precursor proteins into mammalian microsomes. (PubMed id 8096509)9 Wiech H....Jakob U. (J. Biol. Chem. 1993)
    975. Domain structure of the 90-kDa stress protein: heparin- and antibody-binding domain. (PubMed id 7680324)9 Itoh H. and Tashima Y. (Int. J. Biochem. 1993)
    976. Combined pharmacophore and structure-guided studies to identify diverse HSP90 inhibitors. (PubMed id 20005756)9 Sanam R....Neamati N. (amp 2010)
    977. Biochemical and biophysical characterization of the Mg2+-induced 90-kDa heat shock protein oligomers. (PubMed id 20228408)9 Moullintraffort L....Garnier C. (J. Biol. Chem. 2010)
    978. Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70. (PubMed id 20090934)9 Banerjee Mustafi S....Raha S. (PLoS ONE 2010)
    979. Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. (PubMed id 19996313)9 Chadli A....Mer G. (J. Biol. Chem. 2010)
    980. Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. (PubMed id 20159978)9 Lin J.J. and Hemenway C.S. (J. Biol. Chem. 2010)
    981. The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone. (PubMed id 19932969)9 Mays J.R....Blagg B.S. (amp 2010)
    982. Therapeutic effects of radiolabeled 17-allylamino-17-demethoxygeldanamycin on human H460 nonsmall-cell lung carcinoma xenografts in mice. (PubMed id 20423228)9 Sun J....Huang Y. (amp 2010)
    983. Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. (PubMed id 20007406)9 Pham A.N....Huang Y. (J. Pharmacol. Exp. Ther. 2010)
    984. Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis. (PubMed id 20154064)9 Madrigal-Matute J....MartA-n-Ventura J.L. (Cardiovasc. Res. 2010)
    985. Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. (PubMed id 20147598)9 Rowlands M....Aherne W. (J Biomol Screen 2010)
    986. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. (PubMed id 20071522)9 Jinwal U.K....Dickey C.A. (J. Neurosci. 2010)
    987. Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment. (PubMed id 20100459)9 Koshimizu T.A....Fujimura A. (Biochem. Biophys. Res. Commun. 2010)
    988. Molecular modelling and docking studies on heat shock protein 90 (Hsp90) inhibitors. (PubMed id 20373211)9 Saxena A.K....Chaudhaery S.S. (SAR QSAR Environ Res 2010)
    989. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. (PubMed id 19148492)9 Gazitt Y....Freeman J. (Int. J. Oncol. 2009)
    990. Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones. (PubMed id 19648961)9 Kang B.H. and Altieri D.C. (Oncogene 2009)
    991. Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. (PubMed id 19364129)9 Ge F....He Q.Y. (J. Proteome Res. 2009)
    992. Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors. (PubMed id 19502802)9 Wang S....Neckers L. (Cell Cycle 2009)
    993. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. (PubMed id 18682579)9 Sauvageot C.M....Wen P.Y. (Neuro-oncology 2009)
    994. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. (PubMed id 19416831)9 Caldas-Lopes E....Chiosis G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    995. The charged linker region is an important regulator of Hsp90 function. (PubMed id 19553666)9 Hainzl O....Richter K. (J. Biol. Chem. 2009)
    996. C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress response. (PubMed id 19467242)9 Song H.O....Ahnn J. (J. Mol. Biol. 2009)
    997. The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. (PubMed id 19850929)9 Suzuki Y....Minami Y. (J. Biol. Chem. 2009)
    998. Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. (PubMed id 19610616)9 Brough P.A....Wright L. (J. Med. Chem. 2009)
    999. SNX-2112, a selective Hsp90 inhibitor, potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK. (PubMed id 18948577)9 Okawa Y....Anderson K.C. (Blood 2009)
    1000. Heat-shock protein 90: a novel autoantigen in human carotid atherosclerosis. (PubMed id 19481753)9 Businaro R....RiganA^ R. (Atherosclerosis 2009)
    1001. Purification of the 90 kDa heat shock protein (hsp90) and simultaneous purification of hsp70/hsc70, hsp90 and hsp96 from mammalian tissues and cells using thiophilic interaction chromatography. (PubMed id 19488974)9 Skarga Y....Morenkov O. (Biomed. Chromatogr. 2009)
    1002. Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activation. (PubMed id 19715605)9 Luikart S.D....Gupta P. (BMC Cell Biol. 2009)
    1003. Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90. (PubMed id 19234467)9 Hessling M....Buchner J. (amp 2009)
    1004. Transcription inhibition of heat shock proteins: a strategy for combination of 17-allylamino-17-demethoxygeldanamycin and actinomycin d. (PubMed id 19383903)9 Cervantes-Gomez F....Gandhi V. (Cancer Res. 2009)
    1005. Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800. (PubMed id 19686236)9 StA1hmer T....Bargou R.C. (Br. J. Haematol. 2009)
    1006. A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s. (PubMed id 19032597)9 Vaughan C.K....Prodromou C. (FEBS J. 2009)
    1007. High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures. (PubMed id 19162015)9 Alcazar A. and Cid C. (Exp. Neurol. 2009)
    1008. Inhibition of HSP90 with pochoximes: SAR and structure-based insights. (PubMed id 19856365)9 Barluenga S....Winssinger N. (Chembiochem 2009)
    1009. Tanespimycin: the opportunities and challenges of targeting heat shock protein 90. (PubMed id 19466875)9 Erlichman C. (Expert Opin Investig Drugs 2009)
    1010. Ansamycin inhibitors of Hsp90: nature's prototype for anti-chaperone therapy. (PubMed id 19860734)9 Porter J.R....West K. (Curr Top Med Chem 2009)
    1011. Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells. (PubMed id 18726712)9 Xiong L....Fan M. (amp 2009)
    1012. Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chain. (PubMed id 18669640)9 Shimamoto S....Kobayashi R. (J. Biol. Chem. 2008)
    1013. The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome. (PubMed id 18045990)9 Peng Y....Schoenberg D.R. (Mol. Biol. Cell 2008)
    1014. A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. (PubMed id 18927314)9 Tse A.N....Schwartz G.K. (Clin. Cancer Res. 2008)
    1015. Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines. (PubMed id 18723483)9 Zajac M....MartA-nez-Delgado B. (Mol. Cancer Ther. 2008)
    1016. Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. (PubMed id 18060774)9 WisAcn S....Gestwicki J.E. (amp 2008)
    1017. Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. (PubMed id 18504430)9 Moran D.M....Maki C.G. (Oncogene 2008)
    1018. Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex. (PubMed id 18573821)9 Matysiak M....Selmaj K. (Mult. Scler. 2008)
    1019. Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing. (PubMed id 18703510)9 Yamano T....Udono H. (J. Biol. Chem. 2008)
    1020. Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advanced solid tumors. (PubMed id 18927309)9 de Bono J.S....Patnaik A. (Clin. Cancer Res. 2008)
    1021. Alcohol exposure regulates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages: implication for TNF-alpha regulation. (PubMed id 18689673)9 Mandrekar P....Kodys K. (J. Leukoc. Biol. 2008)
    1022. Arsenite-induced mitotic death involves stress response and is independent of tubulin polymerization. (PubMed id 18485433)9 Taylor B.F....States J.C. (Toxicol. Appl. Pharmacol. 2008)
    1023. A novel class of small molecule inhibitors of Hsp90. (PubMed id 18785742)9 Yi F. and Regan L. (ACS Chem. Biol. 2008)
    1024. [Relationship between the expression of heat shock protein and genetic damage in peripheral blood of workers exposed to coke oven emissions]. (PubMed id 18302885)9 Zhang J.H....Niu Q. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2008)
    1025. Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin. (PubMed id 18418407)9 Wu L.X....Chen Y.Z. (Leukemia 2008)
    1026. 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines. (PubMed id 18281615)9 Babchia N....Mascarelli F. (amp 2008)
    1027. Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells. (PubMed id 18242595)9 Makondo K....Kimura K. (Eur. J. Pharmacol. 2008)
    1028. Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. (PubMed id 18852123)9 Basak S....Dahiya R. (Mol. Cancer Ther. 2008)
    1029. Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation. (PubMed id 18239673)9 Didelot C....Garrido C. (Cell Death Differ. 2008)
    1030. Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program. (PubMed id 18260120)9 Smith M.A....Houghton P.J. (amp 2008)
    1031. Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin. (PubMed id 18281495)9 Holmes J.L....Workman P. (Cancer Res. 2008)
    1032. Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity. (PubMed id 18243703)9 Onodera H....Ichimura M. (amp 2008)
    1033. Bioresistive identification of heat shock protein 90. (PubMed id 19693369)9 Chandrasekaran A....Maxwell D. (Biomicrofluidics 2008)
    1034. Combination of rapamycin and 17-allylamino-17-demethoxygeldanamycin abrogates Akt activation and potentiates mTOR blockade in breast cancer cells. (PubMed id 18594209)9 Roforth M.M. and Tan C. (Anticancer Drugs 2008)
    1035. [Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells]. (PubMed id 18630678)9 Li X. and Deng H.Y. (Sichuan Da Xue Xue Bao Yi Xue Ban 2008)
    1036. A pivotal role for heat shock protein 90 in Ewing sarcoma resistance to anti-insulin-like growth factor 1 receptor treatment: in vitro and in vivo study. (PubMed id 18676850)9 Martins Alava E. (Cancer Res. 2008)
    1037. Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. (PubMed id 19000834)9 Huang T.Y....Bokoch G.M. (Dev. Cell 2008)
    1038. Beta-actin: a regulator of NOS-3. (PubMed id 17878410)9 Su Y....Block E.R. (Sci. STKE 2007)
    1039. Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins. (PubMed id 18045130)9 Didelot C....Garrido C. (Curr. Med. Chem. 2007)
    1040. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. (PubMed id 17876048)9 Edwards A....Haura E.B. (Mol. Cancer Ther. 2007)
    1041. Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin. (PubMed id 17252137)9 McErlean C.S....Moody C.J. (amp 2007)
    1042. Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition. (PubMed id 17219417)9 Burkitt M....Greenhalf W. (Mol. Carcinog. 2007)
    1043. Seasonal variation in heat shock proteins Hsp70 and Hsp90 expression in an exposed and a shaded habitat of Iris pumila. (PubMed id 17177871)9 ManitaseviA8 S....TuciA8 B. (amp 2007)
    1044. Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. (PubMed id 17510430)9 Ferrario A....Gomer C.J. (Cancer Res. 2007)
    1045. The Hsp90 inhibitor, 17-AAG, prevents the ligand-independent nuclear localization of androgen receptor in refractory prostate cancer cells. (PubMed id 17221841)9 Saporita A.J....Wang Z. (Prostate 2007)
    1046. [Heat shock protein 90 alpha und beta are overexpressed in multiple myeloma cells and critically contribute to survival]. (PubMed id 18314631)9 Andrulis M....Greiner A. (Verh Dtsch Ges Pathol 2007)
    1047. Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. (PubMed id 17209571)9 Morales J.L. and Perdew G.H. (Biochemistry 2007)
    1048. Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. (PubMed id 18220746)9 Stravopodis D.J....Voutsinas G.E. (Curr. Med. Chem. 2007)
    1049. Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol. (PubMed id 17323946)9 Thepchatri P....Snyder J.P. (J. Am. Chem. Soc. 2007)
    1050. Hsp90 inhibitor geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin. (PubMed id 17319785)9 SolA!r P....Fedorocko P. (Neoplasma 2007)
    1051. Hsp90 and the Fanconi anemia pathway: a molecular link between protein quality control and the DNA damage response. (PubMed id 17881891)9 Yamashita T....Sekimoto T. (Cell Cycle 2007)
    1052. Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. (PubMed id 17293044)9 Shen J.H....Shen Y.F. (Neurosci. Lett. 2007)
    1053. Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. (PubMed id 17525527)9 Koga F....Neckers L.M. (Cell Cycle 2007)
    1054. Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation. (PubMed id 17337508)9 Aschner J.L....Fike C.D. (Am. J. Physiol. Lung Cell Mol. Physiol. 2007)
    1055. Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in retinal pigment epithelium cells in vitro. (PubMed id 17870069)9 Wu W.C....Chen J.H. (Exp. Eye Res. 2007)
    1056. Hip is a pro-survival substrate of granzyme B. (PubMed id 17620340)9 Hostetter D.R....Craik C.S. (J. Biol. Chem. 2007)
    1057. Microwave hyperthermia treatment increases heat shock proteins in human skeletal muscle. (PubMed id 17224440)9 Ogura Y....Katamoto S. (Br J Sports Med 2007)
    1058. Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase. (PubMed id 17855507)9 Duval M....Gratton J.P. (Mol. Biol. Cell 2007)
    1059. Role of 90-kDa heat shock protein (Hsp 90) and protein degradation in regulating neuronal levels of G protein-coupled receptor kinase 3. (PubMed id 17179467)9 Salim S. and Eikenburg D.C. (J. Pharmacol. Exp. Ther. 2007)
    1060. Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. (PubMed id 17114002)9 Proisy N....Moody C.J. (amp 2006)
    1061. Emerging Hsp90 inhibitors: from discovery to clinic. (PubMed id 16475922)9 Chiosis G....Moulick K. (Anticancer Agents Med Chem 2006)
    1062. Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents. (PubMed id 16784024)9 Chiosis G....Solit D. (Curr Opin Investig Drugs 2006)
    1063. Inhibitors of the HSP90 molecular chaperone: current status. (PubMed id 16860662)9 Sharp S. and Workman P. (Adv. Cancer Res. 2006)
    1064. Glioma: what is the role of c-Myc, hsp90 and telomerase? (PubMed id 16444580)9 Shervington A....Shervington L. (Mol. Cell. Biochem. 2006)
    1065. Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. (PubMed id 16432176)9 Ma Y....Kumar M.V. (Mol. Cancer Ther. 2006)
    1066. Heat shock protein 90: a unique chemotherapeutic target. (PubMed id 16890800)9 Cullinan S.B. and Whitesell L. (Semin. Oncol. 2006)
    1067. The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase. (PubMed id 16959221)9 Gadelle D....Forterre P. (Biochem. Pharmacol. 2006)
    1068. Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. (PubMed id 16731965)9 Chu F....Burlingame A.L. (Protein Sci. 2006)
    1069. Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. (PubMed id 16443786)9 Davis B.J....Zou M.H. (Diabetes 2006)
    1070. Discovery and development of purine-scaffold Hsp90 inhibitors. (PubMed id 16842155)9 Chiosis G. (Curr Top Med Chem 2006)
    1071. The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity. (PubMed id 16714764)9 Keppler B.R....Jarstfer M.B. (J. Biol. Chem. 2006)
    1072. The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression. (PubMed id 17157164)9 Georgakis G.V....Younes A. (Exp. Hematol. 2006)
    1073. Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. (PubMed id 16428328)9 Ohji G....Yonezawa K. (J. Biochem. 2006)
    1074. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. (PubMed id 16428504)9 Georgakis G.V....Younes A. (Clin. Cancer Res. 2006)
    1075. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. (PubMed id 16392823)9 He H....Chiosis G. (J. Med. Chem. 2006)
    1076. Radanamycin, a macrocyclic chimera of radicicol and geldanamycin. (PubMed id 16464590)9 Wang M....Blagg B.S. (amp 2006)
    1077. Inhibitors of the HSP90 molecular chaperone: attacking the master regulator in cancer. (PubMed id 16842148)9 McDonald E....Jones K. (Curr Top Med Chem 2006)
    1078. Region-specific regulation of glucocorticoid receptor/HSP90 expression and interaction in brain. (PubMed id 16895583)9 Furay A.R....Herman J.P. (J. Neurochem. 2006)
    1079. Heat shock protein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. (PubMed id 16982758)9 Bauer S....Fletcher J.A. (Cancer Res. 2006)
    1080. [The mechanism of apoptosis of chronic myeloid leukemia cells induced by the novel p210 bcr/abl inhibitor berbamine]. (PubMed id 17064567)9 Sun J.R....Xu R.Z. (Zhonghua Yi Xue Za Zhi 2006)
    1081. Proteasome inhibition induces differential heat shock protein response but not unfolded protein response in HepG2 cells. (PubMed id 16767695)9 Liao W....Chan L. (J. Cell. Biochem. 2006)
    1082. A new approach for enhancing differential selectivity of drugs to cancer cells. (PubMed id 17163760)9 Duvvuri M....Krise J.P. (ACS Chem. Biol. 2006)
    1083. Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin. (PubMed id 16273226)9 Fedier A....Fink D. (Int. J. Oncol. 2005)
    1084. Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. (PubMed id 15611262)9 Pittet J.F....Welch W.J. (J. Immunol. 2005)
    1085. Heat shock protein 90 indirectly regulates ERK activity by affecting Raf protein metabolism. (PubMed id 15999212)9 Dou F....Zhu J.J. (Acta Biochim. Biophys. Sin. (Shanghai) 2005)
    1086. The heat shock protein 90 inhibitor, 17-allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. (PubMed id 15930315)9 Price J.T....Thompson E.W. (Cancer Res. 2005)
    1087. Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition. (PubMed id 16267026)9 Guo W....Ross D. (Cancer Res. 2005)
    1088. 17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types. (PubMed id 15661225)9 Gossett D.R....Lin J. (Gynecol. Oncol. 2005)
    1089. Chaperoning steroid hormone signaling via reversible acetylation. (PubMed id 16604172)9 Kovacs J.J....Yao T.P. (Nucl Recept Signal 2005)
    1090. A client-binding site of Cdc37. (PubMed id 16156789)9 Terasawa K. and Minami Y. (FEBS J. 2005)
    1091. Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. (PubMed id 16285732)9 Prince T....Matts R.L. (Biochemistry 2005)
    1092. Cdc37 maintains cellular viability in Schizosaccharomyces pombe independently of interactions with heat-shock protein 90. (PubMed id 16098195)9 Turnbull E.L....Fantes P.A. (FEBS J. 2005)
    1093. Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3. (PubMed id 15514006)9 George P....Bhalla K. (Blood 2005)
    1094. Geldanamycin, a potent and specific inhibitor of Hsp90, inhibits gene expression and replication of human cytomegalovirus. (PubMed id 15889536)9 Basha W....Tanaka J. (amp 2005)
    1095. Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells. (PubMed id 15795242)9 Reyes-Del Valle J....Del Angel R.M. (J. Virol. 2005)
    1096. Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. (PubMed id 15828828)9 Llauger L....Chiosis G. (J. Med. Chem. 2005)
    1097. Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility. (PubMed id 15992426)9 Hassun Filho P.A....Srougi M. (Int Braz J Urol 2005)
    1098. ErbB3 expression predicts tumor cell radiosensitization induced by Hsp90 inhibition. (PubMed id 16061682)9 Dote H....Tofilon P.J. (Cancer Res. 2005)
    1099. Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update. (PubMed id 15757409)9 Neckers L. and Neckers K. (Expert Opin Emerg Drugs 2005)
    1100. Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond. (PubMed id 16555999)9 Georgakis G.V. and Younes A. (Future Oncol 2005)
    1101. HSP90: a rising star on the horizon of anticancer targets. (PubMed id 16556029)9 Dai C. and Whitesell L. (Future Oncol 2005)
    1102. Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up? (PubMed id 16004589)9 Isaacs J.S. (Expert Opin Investig Drugs 2005)
    1103. Hsp90 activation and cell cycle regulation. (PubMed id 15539946)9 Burrows F....Kamal A. (Cell Cycle 2004)
    1104. Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. (PubMed id 15077173)9 Broemer M....Scheidereit C. (Oncogene 2004)
    1105. Heat-shock treatment-mediated increase in transduction by recombinant adeno-associated virus 2 vectors is independent of the cellular heat-shock protein 90. (PubMed id 14711833)9 Zhong L....Srivastava A. (J. Biol. Chem. 2004)
    1106. Biotinylated geldanamycin. (PubMed id 15202892)9 Clevenger R.C....Blagg B.S. (J. Org. Chem. 2004)
    1107. Radiation inactivation analysis of progesterone receptor in human uterine cytosol. (PubMed id 15635938)9 Wu C.M....Pan R.L. (Protein J. 2004)
    1108. Altered Hsp90 function in cancer: a unique therapeutic opportunity. (PubMed id 15299085)9 Bagatell R. and Whitesell L. (Mol. Cancer Ther. 2004)
    1109. Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. (PubMed id 15466438)9 Siligardi G....Prodromou C. (J. Biol. Chem. 2004)
    1110. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. (PubMed id 15145929)9 Murphy P.J....Pratt W.B. (J. Biol. Chem. 2004)
    1111. The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. (PubMed id 15155759)9 Billecke S.S....Osawa Y. (J. Biol. Chem. 2004)
    1112. A time-resolved fluorescence resonance energy transfer-based HTS assay and a surface plasmon resonance-based binding assay for heat shock protein 90 inhibitors. (PubMed id 15265741)9 Zhou V....Gu X.J. (Anal. Biochem. 2004)
    1113. Changed expression of heat shock proteins in various pathological findings in placentas with intrauterine fetal growth restriction. (PubMed id 15449110)9 Wataba K....Kudo R. (Med Electron Microsc 2004)
    1114. CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. (PubMed id 15082798)9 Miyata Y. and Nishida E. (Mol. Cell. Biol. 2004)
    1115. Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors. (PubMed id 15133471)9 Smith-Jones P.M....Larson S.M. (Nat. Biotechnol. 2004)
    1116. Altered states: selectively drugging the Hsp90 cancer chaperone. (PubMed id 15106614)9 Workman P. (Trends Mol Med 2004)
    1117. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. (PubMed id 15296636)9 Kim J....Chiosis G. (J Biomol Screen 2004)
    1118. A comprehensive study on the immunological reactivity of the Hsp90 molecular chaperone. (PubMed id 15632312)9 Kawano T....Nemoto T.K. (J. Biochem. 2004)
    1119. Chaperone-mediated folding and assembly of myosin in striated muscle. (PubMed id 14709723)9 Srikakulam R. and Winkelmann D.A. (J. Cell. Sci. 2004)
    1120. A proteomic approach to cisplatin resistance in the cervix squamous cell carcinoma cell line A431. (PubMed id 15378690)9 Castagna A....Righetti P.G. (Proteomics 2004)
    1121. Independent ATPase activity of Hsp90 subunits creates a flexible assembly platform. (PubMed id 15533447)9 McLaughlin S.H....Jackson S.E. (J. Mol. Biol. 2004)
    1122. Recombinant antibodies: a natural partner in combinatorial antifungal therapy. (PubMed id 15040939)9 Matthews R.C. and Burnie J.P. (Vaccine 2004)
    1123. 17-Allylamino-17-demethoxygeldanamycin activity against thyroid cancer cell lines correlates with heat shock protein 90 levels. (PubMed id 15181088)9 Braga-Basaria M....Ringel M.D. (J. Clin. Endocrinol. Metab. 2004)
    1124. Syntheses of photolabile novobiocin analogues. (PubMed id 15501066)9 Shen G....Blagg B.S. (amp 2004)
    1125. Therapeutic and diagnostic implications of Hsp90 activation. (PubMed id 15177193)9 Kamal A....Burrows F.J. (Trends Mol Med 2004)
    1126. Changes in Hsp90 expression determine the effects of cyclosporine A on the NO pathway in rat myocardium. (PubMed id 14527673)9 Rezzani R....Feron O. (FEBS Lett. 2003)
    1127. Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. (PubMed id 12807878)9 Murphy P.J....Pratt W.B. (J. Biol. Chem. 2003)
    1128. Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. (PubMed id 12820653)9 Masson-Gadais B....Huot J. (amp 2003)
    1129. Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. (PubMed id 14581371)9 Beliakoff J....Whitesell L. (Clin. Cancer Res. 2003)
    1130. Reciprocal variations of nNOS and HSP90 are associated with fasting in gastrointestinal tract of the piglet. (PubMed id 12643617)9 Grongnet J.F. and David J.C. (Dig. Dis. Sci. 2003)
    1131. Function of HSP90 and p23 in the telomerase complex of thyroid tumors. (PubMed id 14621192)9 Boltze C....Hoang-Vu C. (Pathol. Res. Pract. 2003)
    1132. Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. (PubMed id 14695217)9 Bisht K.S....Gius D. (Cancer Res. 2003)
    1133. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. (PubMed id 14507910)9 Morishima Y....Pratt W.B. (J. Biol. Chem. 2003)
    1134. Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells. (PubMed id 12771028)9 Villa R....Zaffaroni N. (Carcinogenesis 2003)
    1135. Intracellular localization of the 90 kDA heat shock protein (HSP90alpha) determined by expression of a EGFP-HSP90alpha-fusion protein in unstressed and heat stressed 3T3 cells. (PubMed id 12713799)9 Langer T....Fasold H. (Cell Biol. Int. 2003)
    1136. Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. (PubMed id 12441346)9 Vanden Berghe T....Vandenabeele P. (J. Biol. Chem. 2003)
    1137. Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor. (PubMed id 12269826)9 Georget V....Sultan C. (Biochemistry 2002)
    1138. Effect of geldanamycin on androgen receptor function and stability. (PubMed id 11894840)9 Vanaja D.K....Young C.Y. (amp 2002)
    1139. Volatile organic compounds cytotoxicity and expression of HSP72, HSP90 and GRP78 stress proteins in cultured human cells. (PubMed id 12183065)9 Croute F....Soleilhavoup J.P. (Biochim. Biophys. Acta 2002)
    1140. Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. (PubMed id 11823472)9 Piatelli M.J....Chiles T.C. (J. Biol. Chem. 2002)
    1141. Geldanamycin attenuates NO-mediated dilation in human skin. (PubMed id 11748067)9 Shastry S. and Joyner M.J. (Am. J. Physiol. Heart Circ. Physiol. 2002)