Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HSP90AA1 Gene

protein-coding   GIFtS: 70
GCID: GC14M102547

Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)
  See HSP90AA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 11 2     LAP22 5
HSPC11 2 3 5     EL522
HSPCA1 2 3 5     HSP90N2
HSP90A2 3 5     HSPCAL12
Heat Shock 90kD Protein 1, Alpha1 2     HSPN2
Heat Shock 90kDa Protein 1, Alpha1 2     Hsp892
Heat Shock 86 KDa2 3     Hsp902
Renal Carcinoma Antigen NY-REN-382 3     Epididymis Luminal Secretory Protein 522
HSP862 3     Heat Shock 90kD Protein 1, Alpha-Like 42
HSP 862 3     Heat Shock 90kD Protein, Alpha-Like 42
HSP89A2 5     Heat Shock Protein HSP 90-Alpha2
HSPCAL42 5     

External Ids:    HGNC: 52531   Entrez Gene: 33202   Ensembl: ENSG000000808247   OMIM: 1405715   UniProtKB: P079003   

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HSP90AA1 Gene:
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded
protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by
co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Jan 2012)

GeneCards Summary for HSP90AA1 Gene:
HSP90AA1 (heat shock protein 90kDa alpha (cytosolic), class A member 1) is a protein-coding gene. Diseases associated with HSP90AA1 include hand-foot-genital syndrome, and lobular neoplasia. GO annotations related to this gene include GTP binding and protein homodimerization activity. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
its substrate recognition, ATPase cycle and chaperone function

summary for HSP90AA1 Gene:
Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for
a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The
Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of
co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and
some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),
transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the
Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress
conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic
proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
         STAT1   p53   MyoD   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence
   Search Chromatin IP Primers for HSP90AA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.31   HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M102547:  view genomic region     (about GC identifiers)

Start:
102,547,075 bp from pter      End:
102,606,086 bp from pter
Size:
59,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)
Recommended Name: Heat shock protein HSP 90-alpha  
Size: 732 amino acids; 84660 Da
Subunit: Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1,
HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with
AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for
correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts
with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding
motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity
Selected PDB 3D structures from and Proteopedia for HSP90AA1 (see all 166):
1BYQ (3D)        1OSF (3D)        1UY6 (3D)        1UY7 (3D)        1UY8 (3D)        1UY9 (3D)    
Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5
Alternative splicing: 2 isoforms:  P07900-1   P07900-2   (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Explore proteomics data for HSP90AA1 at MOPED

Post-translational modifications: 

  • ISGylated1
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA11
  • Ubiquitination2 at Lys58, Lys74, Lys84, Lys112, Lys153, Lys185, Lys191, Lys209, Lys224, Lys283,
                                 Lys292, Lys294, Lys314, Lys327, Lys362, Lys407, Lys419, Lys436, Lys443, Lys446 (see all 27)
  • Modification sites at PhosphoSitePlus

  • See HSP90AA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001017963.2  NP_005339.3  

    ENSEMBL proteins: 
     ENSP00000216281   ENSP00000335153   ENSP00000451400   ENSP00000450712   ENSP00000452241  
     ENSP00000396189  
    Reactome Protein details: P07900

    HSP90AA1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HSP90AA1 (HSP90 alpha)
    Enzo Life Sciences proteins for HSP90AA1
    OriGene Purified Proteins for HSP90AA1
    OriGene Protein Over-expression Lysate for HSP90AA1
    OriGene MassSpec for HSP90AA1
    OriGene Custom Protein Services for HSP90AA1
    GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1
    Novus Biologicals HSP90AA1 Proteins
    Novus Biologicals HSP90AA1 Lysates
    Sino Biological Recombinant Protein for HSP90AA1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSP90AA1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HSP90AA1 

    HSP90AA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
    R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
    Cell Signaling Technology (CST) Antibodies for HSP90AA1  (HSP90A)
    OriGene Antibodies for HSP90AA1
    OriGene Custom Antibody Services for HSP90AA1
    Novus Biologicals HSP90AA1 Antibodies
    Abcam antibodies for HSP90AA1 (P08238, P07900)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HSP90AA1
    LSBio Antibodies in human, mouse, rat for HSP90AA1

    HSP90AA1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSP90AA1
    R&D Systems Ubiquitin Proteasome Pathway (UPP) Assay Kits & Reagents for HSP90AA1 (HSP90 alpha)
    GenScript Custom Assay Services for HSP90AA1
    Enzo Life Sciences assays for HSP90AA1
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HSP90AA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HSPC: Heat shock proteins / HSPC

    5 InterPro protein domains:
     IPR001404 Hsp90_fam
     IPR020575 Hsp90_N
     IPR020568 Ribosomal_S5_D2-typ_fold
     IPR003594 HATPase_ATP-bd
     IPR019805 Heat_shock_protein_90_CS

    Graphical View of Domain Structure for InterPro Entry P07900

    ProtoNet protein and cluster: P07900

    2 Blocks protein domains:
    IPB001404 Heat shock protein Hsp90
    IPB003594 ATP-binding region


    UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900
    Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the
    co-chaperone STUB1
    Similarity: Belongs to the heat shock protein 90 family


    Find genes that share domains with HSP90AA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HS90A_HUMAN, P07900
    Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of
    specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a
    functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the
    client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate
    its substrate recognition, ATPase cycle and chaperone function

         Gene Ontology (GO): 20 molecular function terms (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS11470816
    GO:0002134UTP binding ----
    GO:0002135CTP binding ----
    GO:0003729mRNA binding ----
    GO:0005515protein binding IPI12526792
    GO:0005524ATP binding TAS11470816
    GO:0005525GTP binding ----
    GO:0016887ATPase activity IDA15937123
    GO:0017098sulfonylurea receptor binding ----
    GO:0019901protein kinase binding ----
    GO:0019903protein phosphatase binding ----
    GO:0023026MHC class II protein complex binding IDA--
    GO:0030235nitric-oxide synthase regulator activity IDA15937123
    GO:0030911TPR domain binding TAS12526792
    GO:0032564dATP binding ----
    GO:0042802identical protein binding IPI16169070
    GO:0042803protein homodimerization activity TAS11470816
    GO:0044325ion channel binding ----
    GO:0044822poly(A) RNA binding IDA--
    GO:0051082unfolded protein binding IEA--
         
    Find genes that share ontologies with HSP90AA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HSP90AA1:
     Wnt reporter upregulated 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsp90aa1):
     cellular  endocrine/exocrine gland  immune system  mortality/aging  reproductive system 

    Find genes that share phenotypes with HSP90AA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSP90AA1: Hsp90aa1tm1(KOMP)Wtsi Hsp90aa1tm1.1Udon

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSP90AA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSP90AA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSP90AA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSP90AA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSP90AA1:
    hsa-mir-25-3p (MIRT050304), hsa-mir-30c-5p (MIRT047953), hsa-mir-30e-5p (MIRT044155), hsa-mir-186-5p (MIRT045178), hsa-mir-183-5p (MIRT047124), hsa-mir-421 (MIRT039416), hsa-mir-501-5p (MIRT041140), hsa-mir-378a-3p (MIRT043944), hsa-mir-3943 (MIRT052896), hsa-let-7b-5p (MIRT052238), hsa-mir-324-3p (MIRT042829), hsa-mir-425-5p (MIRT039331), hsa-mir-484 (MIRT041642), hsa-mir-204-5p (MIRT047015), hsa-mir-222-3p (MIRT046648), hsa-mir-1226-3p (MIRT036428), hsa-mir-16-5p (MIRT031959), hsa-mir-375 (MIRT020063), hsa-mir-760 (MIRT036729), hsa-mir-185-5p (MIRT045325), hsa-mir-17-5p (MIRT050979), hsa-mir-10a-5p (MIRT047507)

    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSP90AA1

    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    Sino Biological Human cDNA Clone for HSP90AA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSP90AA1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HS90A_HUMAN, P07900: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from
    stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    endoplasmic reticulum3
    nucleus3
    chloroplast2
    cytoskeleton2
    endosome2
    extracellular2
    mitochondrion2
    vacuole2
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HSP90AA1 About   (see all 58)  
    See pathways by source

    SuperPathContained pathways About
    1Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    NOD-like receptor signaling pathway0.37
    NOD pathway0.33
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    3Influenza Viral RNA Transcription and Replication
    Influenza Viral RNA Transcription and Replication0.90
    Influenza Infection0.80
    Influenza Life Cycle0.82
    vRNP Assembly0.00
    4Metabolism of nitric oxide
    eNOS activation0.00
    eNOS activation and regulation0.00
    Metabolism of nitric oxide
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation0.00
    5Signaling by FGFR
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with HSP90AA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HSP90AA1
        Apoptosis Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSP90AA1 (see all 11)
        Telomerase Components in Cell Signaling
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    HIF1Alpha Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for HSP90AA1
        Protein Stability

    1 Tocris Bioscience Pathway for HSP90AA1
        MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)
        Development VEGF signaling via VEGFR2 - generic cascades
    Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    Signal transduction AKT signaling
    Immune response Antigen presentation by MHC class I
    CFTR folding and maturation (norm and CF)

    Selected BioSystems Pathways for HSP90AA1 (see all 20)
        NOD pathway
    EBV LMP1 signaling
    IL-6 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    AhR pathway


    Selected Reactome Pathways for HSP90AA1 (see all 15)
        vRNP Assembly
    HSF1-dependent transactivation
    Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
    Scavenging by Class F Receptors
    Recruitment of mitotic centrosome proteins and complexes

    1 PharmGKB Pathway for HSP90AA1
        Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for HSP90AA1) (see all 8):
        Protein processing in endoplasmic reticulum
    PI3K-Akt signaling pathway
    Antigen processing and presentation
    NOD-like receptor signaling pathway
    Progesterone-mediated oocyte maturation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSP90AA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSP90AA1 (P079001, 2, 3 ENSP000003351534) via UniProtKB, MINT, STRING, and/or I2D (see all 1755)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    HSPA1AP081073, ENSP000003648024I2D: score=2 STRING: ENSP00000364802
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0001764neuron migration ----
    GO:0003009skeletal muscle contraction ----
    GO:0006200ATP catabolic process IDA15937123

    Find genes that share ontologies with HSP90AA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for HSP90AA1 (see all 19)     About this table
    CompoundAction CAS #
    17-AAG (KOS953)ansamycin antibiotic which acts as an anti-tumor agent[75747-14-7]
    17-AAG Hydrochloridebinds to Hsp90 and alters its function[911710-03-7]
    17-DMAG (Alvespimycin) HClpotent HSP90 inhibitor[467214-21-7]
    Alvespimycinselective Hsp90 inhibitor[467214-20-6]
    AT13387non-geldanamycin HPS90[912999-49-6]
    AUY922 (NVP-AUY922)potent, novel synthetic resorcinylic isoxazole amide inhibitor of HSP90[747412-49-3]
    BIIB021oral fully synthetic Hsp90 inhibitor[848695-25-0]
    Ganetespib (STA-9090)potent small-molecule inhibitor of Hsp90[888216-25-9]
    IPI-504 (Retaspimycin hydrochloride)selective inhibitor of Hsp90[857402-63-2]
    KW-2478novel and potent nonansamycin inhibitor of Hsp90[819812-04-9]

    Compounds for HSP90AA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    17-AAGSelective Hsp90 inhibitor[75747-14-7]
    PU H71Potent Hsp90 inhibitor[873436-91-0]
    GeduninHsp90 inhibitor; exhibits anticancer and antimalarial activity[2753-30-2]
    GeldanamycinSelective Hsp90 inhibitor[30562-34-6]
    RadicicolHsp90 inhibitor. Antifungal antibiotic[12772-57-5]

    Selected DrugBank Compounds for HSP90AA1 (see all 45)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    RifabutinAnsatipin (see all 7)72559-06-9targetother/unknown10701840 10919672 11306472 10759403 11358819
    17-Dmag-- --target--17139284 17016423 10592235
    4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid-- --target--17139284 17016423 10592235
    4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole-- --target--17139284 17016423 10592235
    Adenosine-5'-Diphosphate-- 20398-34-9target--17139284 17016423
    Geldanamycin-- 30562-34-6target--17139284 17016423
    Nedocromil-- 69049-73-6target--12803546 17980980
    (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one-- --target--10592235
    (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime-- --target--10592235
    2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HSP90AA1 gene (see all 113)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 97.9 855 12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
    17-(allylamino)-17-demethoxygeldanamycin 96.8 351 15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
    radicicol 95.8 209 9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
    17-amino-17-demethoxygeldanamycin 85.5 4 14571691 (1), 16854066 (1), 9890555 (1)
    17-dmag 83.4 6 15338192 (4), 17088927 (1), 12725864 (1)
    lbh-589 76 13 15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
    novobiocin 75.3 91 15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
    molybdate 70.4 37 10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
    steroid 67 202 8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
    herbimycin a 66.9 27 12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)



    Find genes that share compounds with HSP90AA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts): 
    NM_001017963.2  NM_005348.3  

    Unigene Cluster for HSP90AA1:

    Heat shock protein 90kDa alpha (cytosolic), class A member 1
    Hs.525600  [show with all ESTs]
    Unigene Representative Sequence: NM_001017963
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)
    ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662
    ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSP90AA1 (see all 16):
    hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHSP90AA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSP90AA1
    Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1
    Clone
    Products:
         
    OriGene clones in human, mouse for HSP90AA1 (see all 13)
    OriGene ORF clones in mouse, rat for HSP90AA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSP90AA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
      QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
      QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

    Additional mRNA sequence: 

    AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1 
    AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2 
    BX247955.1 BX248761.1 GQ149083.1 X07270.1 X15183.1 

    Selected DOTS entries (see all 224):

    DT.100849252  DT.91781494  DT.100658316  DT.100730414  DT.91845523  DT.95129185  DT.100730410  DT.100801571 
    DT.100730420  DT.98131982  DT.100680135  DT.100860129  DT.100730476  DT.92061474  DT.100730481  DT.100857433 
    DT.100730448  DT.100662911  DT.120782168  DT.97848044  DT.95378226  DT.100846879  DT.100730426  DT.100730485 

    Selected AceView cDNA sequences (see all 2627):

    BP354234 BM839745 BG393826 BQ685380 BX438647 BP357786 CR623660 CD358934 
    BM833745 BU581404 BM771323 BM770685 BP429471 BM771415 BM745750 BM792103 
    BM557327 BP363023 BM770054 BP365062 BU145598 BM818131 AI015385 BP363421 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
    SP1:                          -                 -     -                                                                                                         
    SP2:                                                  -                                                                                                         
    SP3:                                                  -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16a · 16b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for HSP90AA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HSP90AA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACTAGTCCT
    HSP90AA1 Expression
    About this image


    HSP90AA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Tooth (Integumentary System)
             Dental Enamel
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
    HSP90AA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSP90AA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525600
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSP90AA1 (see all 18): 
              Antiviral Response in human mouse rat
              Lymphoma in human mouse rat
              Inflammasomes in human mouse rat
              Autophagy in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1
    QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
    QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSP90AA1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsp90aa11 , 5 heat shock protein 90, alpha (cytosolic), class A member more1, 5 90.12(n)1
    98.77(a)1
      12 (60.75 cM)5
    155191  NM_010480.51  NP_034610.11 
     1106906055 
    chicken
    (Gallus gallus)
    Aves HSP90AA11 heat shock protein 90kDa alpha (cytosolic), class A more 82.01(n)
    95.6(a)
      423463  NM_001109785.1  NP_001103255.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSP90AA16
    heat shock protein 90kDa alpha (cytosolic), class ...
    82(a)
    1 ↔ 1
    GL343742.1(74458-74844)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsp90aa1.11 heat shock protein 90kDa alpha (cytosolic), class A more 79.83(n)
    93.26(a)
      549036  NM_001016282.2  NP_001016282.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF068773.12   -- 77.42(n)   30591  AF068773.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsp836
    Heat shock protein 83
    78(a)
    1 → many
    3L(3192969-3197059)
    worm
    (Caenorhabditis elegans)
    Secernentea daf-216
    Protein DAF-21 (daf-21) mRNA, complete cds
    77(a)
    1 → many
    V(14684918-14688543) WBGene00000915
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSC82(YMR186W)4 Cytoplasmic chaperone of the Hsp90 family, redundant more   --   13(632355-634472) 855224  NP_013911.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSP81-21 HSP81-2 67.96(n)
    71.47(a)
      835701  NM_124985.4  NP_200414.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04821001 Os09g0482100 66.43(n)
    71.65(a)
      4347402  NM_001070035.1  NP_001063500.1 


    ENSEMBL Gene Tree for HSP90AA1 (if available)
    TreeFam Gene Tree for HSP90AA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HSP90AA1 gene
    HSP90AB12  
    14 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries:     HS90A_HUMAN (see all proteins):
    HSP90Af    EL52    HSP90AA2    HSP90AB1    HSP90Be    HSP90B1
    HSP90AB3P    TRA1    HSP90AB4P    GRP94c    HSP90B2P    TRAP1
    HSP90Bf    HSP90AB2P

    Find genes that share paralogs with HSP90AA1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
    PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HSP90AA1 (see all 1394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs679323211,2
    C--82751808(+) TTTTT-/TT/TTT
            
    GAGAC
    1 -- int11NA 2
    rs556835511,2
    C--83556227(+) TTTTT-/TTT/TT
    TT
    /TTTTT
    GTGAC
    1 -- int11NA 2
    rs22774661,2
    C,F,H--102546600(+) CGAAGG/AGGATT 2 -- int18Minor allele frequency- A:0.04EA NS 1648
    rs80206531,2
    C,F,H--102546637(+) CTAAAC/TGTGAT 2 -- int18Minor allele frequency- T:0.10EA NS NA WA 444
    rs118477091,2
    C,F,H--102546812(+) CTAACC/GAAGTT 2 -- int19Minor allele frequency- G:0.03NS EA NA WA 472
    rs49061771,2
    C,F,H--102546964(+) TGCAGT/CGCAAT 2 -- int114Minor allele frequency- C:0.06NA WA CSA EA 377
    rs1893381421,2
    --102547014(+) TCAAGC/TGATTC 2 -- int10--------
    rs1911791351,2
    C--102547064(+) GAACTA/TTGAGA 2 -- int10--------
    rs1399252321,2
    C--102547085(+) CCAAGA/GAATTA 2 -- ut310--------
    rs1844208051,2
    --102547092(+) ATTAAC/GTGACT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HSP90AA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670326CNV Deletion23128226
    nsv1428CNV Insertion18451855
    esv25342CNV Loss19812545
    nsv832879CNV Loss17160897
    dgv25n68CNV Loss17160897

    Human Gene Mutation Database (HGMD): HSP90AA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSP90AA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 140571    OMIM disorders: --

    5 diseases for HSP90AA1:    
    About MalaCards
    hand-foot-genital syndrome    lobular neoplasia    neuronal intranuclear inclusion disease    primary hyperoxaluria
    gastrointestinal stromal tumor

    3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:
    Cancer     Nephritis     Vascular disease

    Find genes that share disorders with HSP90AA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSP90AA1 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 92.7 1012 16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3) (see all 99)
    cancer 62.7 485 16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5) (see all 99)
    tumors 53.5 338 17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4) (see all 99)
    breast cancer 42.1 80 17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3) (see all 41)
    neurodegenerative diseases 39.5 12 19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1) (see all 7)
    myeloid leukemia chronic 36.8 3 10939589 (2), 15514006 (1)
    leukemia 32.7 40 14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2) (see all 24)
    prostate cancer 30.2 21 14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1) (see all 14)
    colon cancer 26 18 18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1) (see all 12)
    myeloma 25.5 21 16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2) (see all 10)

    Genetic Association Database (GAD): HSP90AA1
    Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

    Export disorders for HSP90AA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HSP90AA1 gene, integrated from 10 sources (see all 1998):
    (articles sorted by number of sources associating them with HSP90AA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)1, 2, 3, 9 Chen B.... Monteiro A. (Genomics 2005)
    2. Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)1, 2, 3 Hickey E.... Weber L.A. (Mol. Cell. Biol. 1989)
    3. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)1, 2, 9 Obermann W.M.... Hartl F.U. (J. Cell Biol. 1998)
    4. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2, 9 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    5. Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)1, 2, 9 Young J.C.... Hartl F.U. (J. Biol. Chem. 1998)
    6. Hsp90 is regulated by a switch point in the C-terminal domain. (PubMed id 19696785)1, 2, 9 Retzlaff M....Buchner J. (EMBO Rep. 2009)
    7. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. (PubMed id 11274138)1, 2, 9 Forsythe H.L.... Holt S.E. (J. Biol. Chem. 2001)
    8. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)1, 2, 9 Martinez-Ruiz A.... Lamas S. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    9. Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)1, 2, 9 Brychzy A....Obermann W.M. (EMBO J. 2003)
    10. The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroids. (PubMed id 19254810)1, 4, 9 Hawkins G.A....Bleecker E.R. (J. Allergy Clin. Immunol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3320 HGNC: 5253 AceView: HSPCA Ensembl:ENSG00000080824 euGenes: HUgn3320
    ECgene: HSP90AA1 Kegg: 3320 H-InvDB: HSP90AA1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HSP90AA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HSP90AA1 gene:
    Search GeneIP for patents involving HSP90AA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for HSP90AA1 (HSP90 alpha)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents for HSP90AA1 (HSP90 alpha)  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for HSP90AA1 (HSP90 alpha)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HSP90AA1   OriGene RNAi products in human, mouse, rat for HSP90AA1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HSP90AA1  
     OriGene MassSpec something-or-other for HSP90AA1   OriGene clones in human, mouse for HSP90AA1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSP90AA1   OriGene Purified Protein for HSP90AA1  
     OriGene ORF clones in mouse, rat for HSP90AA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSP90AA1   OriGene Custom Protein Services for HSP90AA1  

     
     
     Block miRNA regulation of human, mouse, rat HSP90AA1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HSP90AA1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSP90AA1 Predesigned siRNA for gene silencing in human, mouse, rat HSP90AA1
     QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1 QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
     PCR Arrays including human, mouse, rat HSP90AA1 Search Chromatin IP Primers for HSP90AA1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSP90AA1  GeneGlobe Interaction Network for HSP90AA1
     Regulatory tfbs in HSP90AA1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1 GenScript cDNA clones with any tag delivered in your preferred vector for HSP90AA1
     GenScript Custom Assay Services for HSP90AA1 GenScript Custom overexpressing Cell Line Services for HSP90AA1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HSP90AA1  (HSP90A)

     Tocris compounds for HSP90AA1
     Proteins for HSP90AA1
     Browse Sino Biological Cell Lysates
     cDNA Clones for HSP90AA1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Assays/Proteins for HSP90AA1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HSP90AA1 antibodies
     HSP90AA1 proteins
     HSP90AA1 lysates
     Antibodies for HSP90AA1
     See all of Abcam's Antibodies, Kits and Proteins for HSP90AA1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSP90AA1
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HSP90AA1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1
     SwitchGear 3'UTR luciferase reporter plasmids for HSP90AA1
     SwitchGear Promoter luciferase reporter plasmids for HSP90AA1
     ThermoFisher Antibody for HSP90AA1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSP90AA1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSP90AA1
     LSBio Antibodies in human, mouse, rat for HSP90AA1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     ApexBio compounds for HSP90AA1
     Search Addgene for plasmids for HSP90AA1
      Search eBioscience for proteins for HSP90AA1
      Search eBioscience for elisas for HSP90AA1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSP90AA1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4