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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSP90AA1 Gene

protein-coding GIFtS: 69
GCID: GC14M102547

heat shock protein 90kDa alpha (cytosolic), class A member...

(Previous names: heat shock 90kD protein 1, alpha, heat shock 90kDa protein...)
(Previous symbols: HSPC1, HSPCA)

Explore 139 diseases affiliated with
HSP90AA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1¹ ²		HSP 86² ³
HSPC1¹ ² ³ ⁵		HSP89A² ⁵
HSPCA¹ ² ³ ⁵		HSPCAL4² ⁵
HSP90A² ³ ⁵		LAP2² ⁵
HSP90N¹ ²		FLJ31884¹
Hsp89¹ ²		EL52²
Hsp90¹ ²		HSPCAL1²
Heat Shock 90kD Protein 1, Alpha¹ ²		HSPN²
Heat Shock 90kDa Protein 1, Alpha¹ ²		Epididymis Luminal Secretory Protein 52²
Heat Shock 86 KDa² ³		Heat Shock 90kD Protein 1, Alpha-Like 4²
Renal Carcinoma Antigen NY-REN-38² ³		Heat Shock 90kD Protein, Alpha-Like 4²
HSP86² ³		Heat Shock Protein HSP 90-Alpha²

External Ids:	HGNC: 5253¹	Entrez Gene: 3320²	Ensembl: ENSG00000080824⁷	OMIM: 140571⁵	UniProtKB: P07900³

Export aliases for HSP90AA1 gene to outside databases

Previous GC identifer: GC14M101619

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSP90AA1:

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein

aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by

co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,

Jan 2012)

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific

target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that

is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby

causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,

ATPase cycle and chaperone function

summary for HSP90AA1:

Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for

a large number of client proteins. Functional Hsp90 operates as dimer and has intrinsic ATPase activity. The

Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70) and is regulated by a number of

co-chaperones/accessory proteins (e.g. Hop, cdc37). Hsp90 has been shown to interact with >100 proteins and

some notable clients include kinases (e.g. Raf-1), nuclear hormone receptors (e.g. estrogen receptors),

transcription factors (e.g. p53), GPCRs (e.g. CB2 receptors) and ion channels (e.g. CFTR). In humans, the

Hsp90beta isoform is constitutively expressed whereas the Hsp90alpha isoforms is expressed under stress

conditions. Hsp90 plays an important role in some tumor cell types by stabilising mutated oncogenic

proteins.

Gene Wiki entry for HSP90AA1 (Heat shock protein 90kDa alpha, member A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSP90AA1 gene promoter:
STAT1 p53 MyoD LCR-F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSP90AA1 promoter sequence

Search SABiosciences Chromatin IP Primers for HSP90AA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.33

HSP90AA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSP90AA1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M102547: view genomic region (about GC identifiers)

Start:	102,547,075 bp from pter	End:	102,606,086 bp from pter
Size:	59,012 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900 (See protein sequence)

Recommended Name: Heat shock protein HSP 90-alpha

Size: 732 amino acids; 84660 Da

Subunit: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together

with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1

and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems

Subcellular location: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I

to stage IV

6/159 PDB 3D structures from and Proteopedia for HSP90AA1 (see all 159):

1BYQ (3D)

1OSF (3D)

1UY6 (3D)

1UY7 (3D)

1UY8 (3D)

1UY9 (3D)

Secondary accessions: A8K500 B3KPJ9 Q2PP14 Q5CAQ6 Q5CAQ7 Q9BVQ5

Alternative splicing: 2 isoforms: P07900-1 P07900-2 (Variant in position: 71:M->L (in dbSNP:rs8005905))

Explore the universe of human proteins at neXtProt for HSP90AA1: NX_P07900

Post-translational modifications:

ISGylated¹

S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07900

HSP90AA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001017963.2 NP_005339.3

ENSEMBL proteins:

ENSP00000216281 ENSP00000335153 ENSP00000451400 ENSP00000450712 ENSP00000452241

ENSP00000396189

Reactome Protein details: P07900
Human Recombinant Protein Products:

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	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for HSP90AA1
	OriGene Purified Proteins (see all 2): HSP90AA1 OriGene Protein Over-expression Lysate (see all 2): HSP90AA1 OriGene Custom Protein Services for HSP90AA1
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	Novus Biologicals HSP90AA1 Proteins Novus Biologicals HSP90AA1 Lysates
	Sino Biological Recombinant Protein for HSP90AA1
	ProSpec Recombinant Protein for HSP90AA1
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0042470	melanosome	IEA	--

HSP90AA1 for ontologies About GeneDecksing

HSP90AA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HSP90AA1
	R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
	Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)
	OriGene Antibodies (see all 5): HSP90AA1 OriGene Custom Antibody Services for HSP90AA1
	GenScript Custom Superior Antibodies Services for HSP90AA1
	Novus Biologicals HSP90AA1 Antibodies
	Abcam antibodies for HSP90AA1
	Browse Antibodies at Uscn
	ThermoFisher Antibody for HSP90AA1

Assay Products for HSP90AA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSP90AA1
	Enzo Life Sciences assays for HSP90AA1
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSP90AA1 for domains About GeneDecksing

5 InterPro domains/families:

IPR001404 Hsp90

IPR020575 Hsp90_N

IPR020568 Ribosomal_S5_D2-typ_fold

IPR003594 ATPase-like_ATP-bd

IPR019805 Heat_shock_protein_90_CS

Graphical View of Domain Structure for InterPro Entry P07900

ProtoNet protein and cluster: P07900

2 Blocks protein families:

IPB001404 Heat shock protein Hsp90

IPB003594 ATP-binding region

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Domain: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone

STUB1

Similarity: Belongs to the heat shock protein 90 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HS90A_HUMAN, P07900

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific

target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that

is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby

causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition,

ATPase cycle and chaperone function

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HSP90AA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
		hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HSP90AA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSP90AA1
		Search LifeMap BioReagents cell lines for HSP90AA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	TAS	11470816
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	TAS	11470816
GO:0016887	ATPase activity	IDA	15937123
GO:0030235	nitric-oxide synthase regulator activity	IDA	15937123

HSP90AA1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for HSP90AA1:

Wnt reporter upregulated

Animal Models:
Mouse knock-outs for HSP90AA1: Hsp90aa1^{tm1(KOMP)Wtsi} Hsp90aa1^tm1.1Udon
5 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hsp90aa1):

cellular

endocrine/exocrine gland

immune system

mortality/aging

reproductive system

HSP90AA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/57 super-pathways (see all 57) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Recruitment of mitotic centrosome proteins and complexes

Recruitment of mitotic centrosome proteins and complexes	1.00	Mitotic G2-G2/M phases	0.81
Centrosome maturation	1.00	Loss of proteins required for interphase microtubule organizationÂ from the centrosome	0.78
G2/M Transition	0.83	Loss of Nlp from mitotic centrosomes	0.78

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	1.00			Development_Glucocorticoid receptor signaling	0.27
	CFTR folding and maturation (norm and CF)	0.37			Development Glucocorticoid receptor signaling	0.27

Metabolism of nitric oxide

	Metabolism of nitric oxide	1.00			Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	0.59
	eNOS activation and regulation	1.00			eNOS activation	0.41

Immune System

Immune System

1.00

Innate Immune System

0.46

Regulation of actin dynamics for phagocytic cup formation

Regulation of actin dynamics for phagocytic cup formation

1.00

Fcgamma receptor (FCGR) dependent phagocytosis

0.80

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for HSP90AA1

	Immune response Antigen presentation by MHC class I
	Development Glucocorticoid receptor signaling
	Selected targets of GCR-alpha
	Signal transduction AKT signaling

1 R&D Systems Pathway for HSP90AA1

Apoptosis Signaling Pathways

5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSP90AA1 (see all 11)

	Telomerase Components in Cell Signaling
	Androgen Signaling
	Glucocorticoid Receptor Signaling
	HIF1Alpha Pathway
	Aldosterone Signaling in Epithelial Cells

1 Cell Signaling Technology (CST) Pathway for HSP90AA1

Protein Stability

1 Tocris Bioscience Pathway for HSP90AA1

MAPK Pathway

5/6 GeneGo (Thomson Reuters) Pathways for HSP90AA1 (see all 6)

	Development VEGF signaling via VEGFR2 - generic cascades
	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
	Signal transduction AKT signaling
	Immune response Antigen presentation by MHC class I
	CFTR folding and maturation (norm and CF)

5/19 BioSystems Pathways for HSP90AA1 (see all 19)

	EBV LMP1 signaling
	NOD pathway
	TNF-alpha/NF-kB Signaling Pathway
	IL-6 Signaling Pathway
	IL-2 Signaling Pathway

5/27 Reactome Pathways for HSP90AA1 (see all 27)

	Developmental Biology
	Metabolism
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Cell Cycle
	Recruitment of mitotic centrosome proteins and complexes

1 PharmGKB Pathway for HSP90AA1

Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics

5/6 Kegg Pathways (Kegg details for HSP90AA1) (see all 6):

	Protein processing in endoplasmic reticulum
	Antigen processing and presentation
	NOD-like receptor signaling pathway
	Progesterone-mediated oocyte maturation
	Pathways in cancer

HSP90AA1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSP90AA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/1596 Interacting proteins for HSP90AA1 (P07900^{1, 2, 3} ENSP00000335153⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 1596)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP5C	P53041¹^,²^,³, ENSP00000012443⁴	EBI-2211817,EBI-716663 MINT-8204116 MINT-8204092 I2D: score=12 STRING: ENSP00000012443
RPS3A	P61247¹^,²^,³, ENSP00000346050⁴	EBI-2211817,EBI-3440915 MINT-63931 I2D: score=5 STRING: ENSP00000346050
MAP3K7	O43318²^,³, ENSP00000358335⁴	MINT-6797194 MINT-6797182 MINT-48032 MINT-6797216 MINT-6797232 MINT-49246 I2D: score=1 STRING: ENSP00000358335
CDC37	Q16543²^,³, ENSP00000222005⁴	MINT-6797194 MINT-6797182 MINT-6797216 MINT-6797232 I2D: score=10 STRING: ENSP00000222005
TAB1	Q15750²^,³, ENSP00000216160⁴	MINT-49177 MINT-6797194 MINT-6797216 I2D: score=2 STRING: ENSP00000216160

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006200	ATP catabolic process	IDA	15937123
GO:0006457	protein folding	--	--
GO:0006839	mitochondrial transport	TAS	12526792

HSP90AA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSP90AA1 for compounds About GeneDecksing

EMD Millipore small molecules for HSP90AA1:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for HSP90AA1 available from Tocris Bioscience About this table

Compound	Action	CAS #
CCT 018159	Hsp90 inhibitor	[171009-07-7]
17-AAG	Selective Hsp90 inhibitor	[75747-14-7]
Macbecin I	Hsp90 inhibitor	[73341-72-7]
Gedunin	Hsp90 inhibitor; anticancer and antimalarial activity	[2753-30-2]
Radicicol	Hsp90 inhibitor. Antifungal antibiotic	[12772-57-5]

10/45 DrugBank Compounds for HSP90AA1 (see all 45) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Rifabutin	Ansatipin (see all 7)	72559-06-9	target	other/unknown	10701840 10919672 11306472 10759403 11358819
17-Dmag	--	--	target	--	17139284 17016423 10592235
4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid	--	--	target	--	17139284 17016423 10592235
4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole	--	--	target	--	17139284 17016423 10592235
Adenosine-5'-Diphosphate	--	20398-34-9	target	--	17139284 17016423
Geldanamycin	--	30562-34-6	target	--	17139284 17016423
Nedocromil	--	69049-73-6	target	--	12803546 17980980
(3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one	--	--	target	--	10592235
(5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime	--	--	target	--	10592235
2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol	--	--	target	--	10592235

10/113 Novoseek chemical compound relationships for HSP90AA1 gene (see all 113) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
geldanamycin	97.9	855	12820659 (8), 16684877 (6), 15271357 (6), 19734938 (5) (see all 99)
17-(allylamino)-17-demethoxygeldanamycin	96.8	351	15841378 (5), 16634649 (4), 19082595 (4), 15057143 (3) (see all 99)
radicicol	95.8	209	9672245 (4), 10383157 (3), 15155759 (3), 15884943 (3) (see all 99)
17-amino-17-demethoxygeldanamycin	85.5	4	14571691 (1), 16854066 (1), 9890555 (1)
17-dmag	83.4	6	15338192 (4), 17088927 (1), 12725864 (1)
lbh-589	76	13	15514006 (2), 17876048 (2), 18070720 (1), 17699868 (1) (see all 7)
novobiocin	75.3	91	15209518 (8), 16421106 (5), 19935870 (4), 10945979 (4) (see all 36)
molybdate	70.4	37	10090774 (4), 9738900 (3), 16285732 (2), 15258137 (2) (see all 21)
steroid	67	202	8625242 (5), 9183567 (5), 9148915 (5), 10689618 (4) (see all 99)
herbimycin a	66.9	27	12145695 (3), 14698045 (1), 11007781 (1), 11360191 (1) (see all 21)

Search CenterWatch for drugs/clinical trials and news about HSP90AA1 / HS90A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSP90AA1 gene (2 alternative transcripts):

NM_001017963.2 NM_005348.3

Unigene Cluster for HSP90AA1:

Heat shock protein 90kDa alpha (cytosolic), class A member 1

Hs.525600 [show with all ESTs]

Unigene Representative Sequence: NM_001017963

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216281(uc001ykx.1 uc001yku.4) ENST00000334701(uc001ykv.4)

ENST00000554401 ENST00000557089 ENST00000560130 ENST00000553585 ENST00000555662

ENST00000556554 ENST00000557234 ENST00000558600 ENST00000441629(uc001ykw.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HSP90AA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSP90AA1
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSP90AA1 (see all 16):
		hsa-miR-495 hsa-miR-361-5p hsa-miR-7-2* hsa-miR-589* hsa-miR-519e hsa-miR-3647-3p hsa-miR-570 hsa-miR-374a*

		SwitchGear 3'UTR luciferase reporter plasmid: HSP90AA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1 (see all 7) OriGene shRNA RFP: HSP90AA1 OriGene siRNA: HSP90AA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HSP90AA1 (NM_001017963)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSP90AA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

Additional cDNA sequence:

AF028832.1 AJ890082.1 AJ890083.1 AK056446.1 AK129557.1 AK291115.1 AK291607.1 AK300126.1

AK310595.1 BC000987.2 BC001695.2 BC007989.2 BC017233.2 BC023006.1 BC108695.1 BC121062.2

BX247955.1 BX248761.1 X07270.1 X15183.1

24/211 DOTS entries (see all 211):

DT.100849252 DT.91781494 DT.100658316 DT.91845523 DT.100730414 DT.100730410 DT.100801571 DT.100730420

DT.95129185 DT.98131982 DT.100680135 DT.100730476 DT.100860129 DT.92061474 DT.100730481 DT.100857433

DT.100730448 DT.120782168 DT.100846879 DT.97848044 DT.100662911 DT.95378226 DT.100730426 DT.97848122

24/2627 AceView cDNA sequences (see all 2627):

CB124900 BM761115 BX438647 CB243663 BQ651916 BQ639882 BM472848 CA417925

BP361918 BM827359 BQ709040 BQ028824 BQ431360 BE328211 AA381831 AA313331

BP371203 BQ687650 CR593964 BI856817 AA234219 AA779056 BE501582 BE783147

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 (see all 14) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	^
SP1:									-						-		-
SP2:																	-
SP3:																	-
SP4:
SP5:

ExUns:	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HSP90AA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSP90AA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACTAGTCCT

About this image

HSP90AA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Liver

Liver Lobule

Liver

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

See HSP90AA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSP90AA1

SOURCE GeneReport for Unigene cluster: Hs.525600

SABiosciences Expression via Pathway-Focused PCR Arrays including HSP90AA1 (see all 18):

Antiviral Response in human mouse rat

Lymphoma in human mouse rat

Inflammasomes in human mouse rat

Autophagy in human mouse rat

T-cell & B-cell Activation in human mouse rat

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for HSP90AA1 gene from 10/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hsp90aa1^{1 , 5}	heat shock protein 90, alpha (cytosolic), class A member more^{1, 5}	90.3(n)¹ 99.18(a)¹		12 (60.75 cM)⁵ 15519¹ NM_010480.5¹ NP_034610.1¹ 110690605⁵
chicken (Gallus gallus)	Aves	HSP90AA1¹	heat shock protein 90kDa alpha (cytosolic), class A more	82.37(n) 96.43(a)		423463 NM_001109785.1 NP_001103255.1
lizard (Anolis carolinensis)	Reptilia	HSP90AA1⁶	--	97(a)	1 ↔ 1	GL343232.1(1912641-1917038)
zebrafish (Danio rerio)	Actinopterygii	AF068773.1²	--	77.42(n)		30591 AF068773.1
fruit fly (Drosophila melanogaster)	Insecta	Hsp83⁶	Heat shock protein 83	79(a)	possible ortholog	3L(3192969-3197059)
worm (Caenorhabditis elegans)	Secernentea	daf-21⁶	Heat shock protein 90	77(a)	possible ortholog	V(14684903-14688528)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HSC82(YMR186W)⁴ HSP82¹	Cytoplasmic chaperone of the Hsp90 family, redundant more⁴ Hsp82p¹	62.96(n)¹ 64.05(a)¹		13(632355-634472)⁴ 855836¹ NP_015084.1¹ 855224⁴ NP_013911.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	HSP90.1¹	heat shock protein 81-1	66.81(n) 73.81(a)		835341 NM_124642.3 NP_200076.1
rice (Oryza sativa)	Liliopsida	-- -- (see all 9)	heat shock protein, putative, expressed (see all 9)	72(a) 71(a) (see all 9)	possible ortholog possible ortholog (see all 9)	9(18513571-18517315) 8(24716372-24720839)
E. coli (Escherichia coli)	Gamma proteobacteria	htpG⁶	protein refolding molecular co-chaperone Hsp90, Hs...	39(a)	possible ortholog	Chromosome(494344-496218)

ENSEMBL Gene Tree for HSP90AA1 (if available)
TreeFam Gene Tree for HSP90AA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSP90AA1 gene

HSP90B1² HSP90AB1² TRAP1²

13 SIMAP similar genes for HSP90AA1 using alignment to 8 protein entries: HS90A_HUMAN (see all proteins):

HSP90Af HSP90AB1 HSP90AA2 HSP90Be HSP90B1 HSP90AB3P

TRA1 HSP90AB4P GRP94c HSP90B2P TRAP1 HSP90Bf

HSP90AB2P

HSP90AA1 for paralogs About GeneDecksing

5/6 Pseudogenes.org Pseudogenes for HSP90AA1 (see all 6)
PGOHUM00000258562 PGOHUM00000245028 PGOHUM00000240280 PGOHUM00000259879 PGOHUM00000245768

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2277466^1,2	C,F,H,	--	102546600(+)	`CGAAGG/AGGATT`	2	--	int¹		8		EA NS	1648
rs8020653^1,2	C,F,H,	--	102546637(+)	`CTAAAC/TGTGAT`	2	--	int¹		8		EA NS NA WA	444
rs11847709^1,2	C,F,H,	--	102546812(+)	`CTAACC/GAAGTT`	2	--	int¹		9		NS EA NA WA	472
rs4906177^1,2	C,F,H,	--	102546964(+)	`TGCAGT/CGCAAT`	2	--	int¹		14		NA WA CSA EA	377
rs189338142^1,2		--	102547014(+)	`TCAAGC/TGATTC`	2	--	int¹		0	--	--	--	--
rs191179135^1,2		--	102547064(+)	`GAACTA/TTGAGA`	2	--	int¹		0	--	--	--	--
rs139925232^1,2		--	102547085(+)	`CCAAGA/GAATTA`	2	--	ut3¹		0	--	--	--	--
rs184420805^1,2		--	102547092(+)	`ATTAAC/GTGACT`	2	--	ut3¹		0	--	--	--	--
rs1059629^1,2	C,F,H,	--	102547105(-)	`CTGTGC/TTAAAT`	2	--	ut3¹		23		NA NS EA WA CSA	1791
rs150605311^1,2		--	102547184(+)	`GGGATC/GCATGT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HSP90AA1 (102547075 - 102606086 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HSP90AA1
3 CNVs: 76736 66711 87364
1 Indel: 87365
Human Gene Mutation Database (HGMD): HSP90AA1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AA1

DNA2.0 Custom Variant and Variant Library Synthesis for HSP90AA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSP90AA1 for disorders           About GeneDecksing

OMIM gene information: 140571    OMIM disorders: --

20/139 diseases for HSP90AA1 (see all 139):    About MalaCards

hand-foot-genital syndrome dopa-responsive dystonia atypical teratoid rhabdoid tumor renal carcinoma

carcinoma anaplastic large cell lymphoma peutz-jeghers syndrome neuronal intranuclear inclusion disease

gastrointestinal stromal tumor lichen planus long qt syndrome oral lichen planus

waldenstrom macroglobulinemia malignant pleural mesothelioma non-hodgkin lymphoma lobular neoplasia

ataxia telangiectasia rhabdoid tumors amyotrophic lateral sclerosis myasthenia gravis

3 diseases from the University of Copenhagen DISEASES database for HSP90AA1:

Cancer Nephritis Vascular disease

10/91 Novoseek disease relationships for HSP90AA1 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	92.7	1012	16452239 (5), 16218955 (4), 19860731 (3), 20142037 (3), 15347681 (3), 14529386 (3), 12427754 (3), 10946285 (3), 17681020 (3), 17977914 (3), 8157642 (3), 9141521 (2), 9693973 (2), 9710578 (2), 12643617 (2), 10632574 (2), 9705856 (2), 15338192 (2), 18442981 (2), 18594209 (2), 15455381 (2), 11771959 (2), 10636845 (2), 10066374 (2), 9066981 (2), 9222590 (2), 20154064 (2), 9295332 (2), 7779083 (2), 1551911 (2), 11969290 (2), 11147836 (2), 9824379 (2), 8804713 (2), 8625242 (2), 19749793 (2), 20373211 (2), 12527207 (2), 12521608 (2), 10983842 (2), 10669794 (2), 9933607 (2), 9461509 (2), 20147598 (2), 19466875 (2), 19372565 (2), 18950863 (2), 17698952 (2), 17177871 (2), 10955818 (2), 8892646 (2), 7714077 (2), 7811761 (2), 20228408 (2), 19488974 (2), 16923571 (2), 12713799 (2), 12460647 (2), 17688194 (2), 12127946 (2), 7856945 (2), 2052560 (2), 19715605 (2), 11399505 (2), 9141440 (2), 7775471 (2), 19552433 (2), 18418733 (2), 2070838 (1), 1313229 (1), 8417966 (1), 8319210 (1), 7961671 (1), 9228040 (1), 11792853 (1), 11463862 (1), 11280726 (1), 10938586 (1), 10851302 (1), 10383157 (1), 10225950 (1), 10689618 (1), 9731032 (1), 16099423 (1), 15977996 (1), 15867239 (1), 15514006 (1), 15174023 (1), 15069952 (1), 14724288 (1), 12972407 (1), 14688203 (1), 18676857 (1), 18343820 (1), 18358234 (1), 18245548 (1), 17878410 (1), 17721082 (1), 17337508 (1) (see top 4)
cancer	62.7	485	16842157 (6), 14624223 (6), 20398291 (5), 17266581 (5), 16610363 (5), 19142186 (5), 18469526 (4), 18347418 (4), 14529382 (4), 17536171 (4), 15013520 (4), 18840695 (4), 16842156 (3), 19179103 (3), 12507224 (3), 15989551 (3), 19414312 (3), 18931700 (3), 12617036 (3), 19689285 (3), 19014912 (3), 16854066 (3), 15106614 (3), 18347186 (3), 15853661 (3), 20148718 (3), 20147598 (3), 18020435 (3), 16842153 (3), 19747088 (3), 19850405 (3), 16452239 (3), 15217612 (2), 15828828 (2), 18497978 (2), 15202892 (2), 16860662 (2), 18807037 (2), 17645779 (2), 17548610 (2), 17163760 (2), 16432176 (2), 15757409 (2), 15661534 (2), 11772336 (2), 20375559 (2), 20005756 (2), 19860732 (2), 16392823 (2), 16004589 (2), 15177193 (2), 19946660 (2), 18504430 (2), 18800240 (2), 18056992 (2), 18220746 (2), 18855578 (2), 19177013 (2), 16555999 (2), 20425593 (2), 20423228 (2), 18089825 (2), 17881891 (2), 16842148 (2), 14657666 (2), 11927289 (2), 20138026 (2), 19601813 (2), 19405528 (2), 19648961 (2), 19528462 (2), 17968312 (2), 17513464 (2), 16784024 (2), 15299085 (2), 14508491 (2), 12213470 (2), 18781898 (2), 17073714 (2), 16441227 (2), 16556029 (2), 12678776 (2), 11251965 (2), 19610616 (2), 19303730 (2), 16475922 (2), 15265741 (2), 19933325 (2), 19860731 (2), 18726985 (2), 16842155 (2), 12727831 (1), 19552433 (1), 20457619 (1), 20159553 (1), 19945858 (1), 19858214 (1), 19956882 (1), 19693369 (1) (see top 4)
tumors	53.5	338	17409397 (5), 17968312 (5), 17671112 (4), 16234364 (4), 11800023 (4), 19229106 (4), 15217612 (3), 19458065 (3), 15455381 (3), 16546966 (3), 19372565 (3), 19946660 (3), 19576239 (3), 15009113 (3), 10697551 (3), 17956728 (3), 17219417 (3), 17163756 (3), 19738418 (3), 18199556 (3), 19855434 (3), 14529387 (2), 15828828 (2), 15338192 (2), 14529389 (2), 14695217 (2), 19948822 (2), 19085954 (2), 18413753 (2), 16061682 (2), 15168026 (2), 14570880 (2), 1601523 (2), 17299090 (2), 15897590 (2), 18037622 (2), 18025273 (2), 18948577 (2), 18676850 (2), 17363505 (2), 19662650 (2), 18781898 (2), 17525527 (2), 15177193 (2), 20395337 (2), 16890800 (2), 15358769 (2), 14600095 (2), 19502802 (2), 12942564 (2), 10383157 (1), 15735699 (1), 16371460 (1), 16982765 (1), 17721082 (1), 16377176 (1), 15695121 (1), 15585643 (1), 15107611 (1), 15057143 (1), 12820659 (1), 19387550 (1), 19364129 (1), 18245548 (1), 12970299 (1), 12881371 (1), 12163643 (1), 11919167 (1), 9744771 (1), 18957107 (1), 18927309 (1), 18852131 (1), 18927314 (1), 16989012 (1), 16449656 (1), 16842154 (1), 15911628 (1), 15592361 (1), 15145929 (1), 15081540 (1), 14687661 (1), 12842893 (1), 16385472 (1), 12441346 (1), 11051811 (1), 20226014 (1), 20371713 (1), 19826195 (1), 19303730 (1), 18089825 (1), 17726540 (1), 16869774 (1), 16634649 (1), 14726679 (1), 15239664 (1), 14967193 (1), 14657666 (1), 14529388 (1), 14529386 (1) (see top 4)
breast cancer	42.1	80	17409397 (5), 18430202 (4), 15269596 (4), 19014541 (3), 16551874 (3), 17487411 (2), 15661225 (2), 20226014 (2), 18630678 (2), 19738418 (2), 19416831 (2), 18723483 (2), 10376793 (2), 1617638 (1), 8878452 (1), 11306472 (1), 19632796 (1), 11489788 (1), 18552146 (1), 15930315 (1), 11489796 (1), 10513983 (1), 10697551 (1), 19747088 (1), 19861537 (1), 15548050 (1), 18304811 (1), 16842157 (1), 16144943 (1), 2355020 (1), 18056992 (1), 17979263 (1), 11244940 (1), 18793708 (1), 15687645 (1), 19855434 (1), 14581371 (1), 9761114 (1), 11120605 (1), 11306353 (1), 11448926 (1) (see top 4)
neurodegenerative diseases	39.5	12	19058963 (1), 19138859 (1), 17942784 (1), 14529386 (1), 17185503 (1), 17536171 (1), 18190862 (1) (see top 4)
myeloid leukemia chronic	36.8	3	10939589 (2), 15514006 (1)
leukemia	32.7	40	14555522 (3), 17332306 (3), 12738674 (2), 15972449 (2), 17064567 (2), 19014912 (2), 11895790 (1), 16682002 (1), 17395781 (1), 15937340 (1), 18591380 (1), 19850405 (1), 11587211 (1), 16034464 (1), 16482209 (1), 18418407 (1), 15483679 (1), 12145695 (1), 14679005 (1), 18660379 (1), 17956279 (1), 14624223 (1), 15625278 (1), 17266581 (1) (see top 4)
prostate cancer	30.2	21	14571418 (3), 17221841 (2), 19948822 (2), 18726985 (1), 16449656 (1), 18954528 (1), 18852123 (1), 19747088 (1), 19805354 (1), 18840695 (1), 19147983 (1), 20373861 (1), 19809428 (1), 17088927 (1) (see top 4)
colon cancer	26	18	18025273 (4), 16774932 (2), 18676857 (1), 18977205 (1), 15457556 (1), 18820127 (1), 20394503 (1), 17114002 (1), 10962573 (1), 18931700 (1), 15993848 (1), 12633846 (1) (see top 4)
myeloma	25.5	21	16923571 (3), 17525289 (3), 19686236 (2), 18314631 (2), 17721082 (1), 18449204 (1), 19747088 (1), 17090671 (1), 16452239 (1), 19996089 (1) (see top 4)

Human Genome Epidemiology (HuGE) Navigator: HSP90AA1 (7 documents)

Export disorders for HSP90AA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSP90AA1 gene, integrated from 9 sources (see all 1901):
(articles sorted by number of sources associating them with HSP90AA1)

Utopia: connect your pdf to the dynamic
world of online information

The HSP90 family of genes in the human genome: insights into their divergence and evolution. (PubMed id 16269234)^{1, 2, 3, 9} Chen B.... Monteiro A. (2005)
Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. (PubMed id 2527334)^{1, 2, 3} Hickey E.... Weber L.A. (1989)
In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis. (PubMed id 9817749)^{1, 2, 9} Obermann W.M.... Hartl F.U. (1998)
A proteomic investigation of ligand-dependent HSP90 c omplexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)^{1, 2, 9} Gano J.J. and Simon J.A. (2010)
Specific binding of tetratricopeptide repeat proteins to the C- terminal 12-kDa domain of hsp90. (PubMed id 9660753)^{1, 2, 9} Young J.C.... Hartl F.U. (1998)
Hsp90 is regulated by a switch point in the C-termina l domain. (PubMed id 19696785)^{1, 2, 9} Retzlaff M....Buchner J. (2009)
S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. (PubMed id 15937123)^{1, 2, 9} Martinez-Ruiz A....Lamas S. (2005)
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. (PubMed id 12853476)^{1, 2, 9} Brychzy A....Obermann W.M. (2003)
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)^{1, 2, 9} Zhang M....Pearl L.H. (2005)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{1, 2} Chi A....Hunt D.F. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3320	HGNC: 5253	AceView: HSPCA	Ensembl:ENSG00000080824	euGenes: HUgn3320
ECgene: HSP90AA1	Kegg: 3320	H-InvDB: HSP90AA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSP90AA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HSP90AA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HSP90AA1 gene:
Search GeneIP for patents involving HSP90AA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSP90AA1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSP90AA1
	OriGene Protein Over-expression Lysate for HSP90AA1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HSP90AA1		OriGene 3'-UTR Clone for HSP90AA1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSP90AA1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HSP90AA1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HSP90AA1		OriGene Custom Protein Services for HSP90AA1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSP90AA1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSP90AA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSP90AA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSP90AA1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSP90AA1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSP90AA1

	GenScript Custom Purified and Recombinant Proteins Services for HSP90AA1		GenScript cDNA clones with any tag delivered in your preferred vector for HSP90AA1
	GenScript Custom Assay Services for HSP90AA1		GenScript Custom Superior Antibodies Services for HSP90AA1
	GenScript Custom overexpressing Cell Line Services for HSP90AA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for HSP90AA1 (HSP90A)

	Regulatory tfbs in HSP90AA1 promoter
	Search Chromatin IP Primers for HSP90AA1
	RT² qPCR Primer Assay in human, mouse, rat HSP90AA1
	GNC Network for HSP90AA1
	SABiosciences PCR Arrays including human, mouse, rat HSP90AA1

Tocris compounds for HSP90AA1

	Proteins and Antibodies for HSP90AA1
	cDNA Clones for HSP90AA1
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays/Proteins for HSP90AA1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HSP90AA1 antibodies
	HSP90AA1 proteins
	HSP90AA1 lysates

	Antibodies for HSP90AA1
	See all of Abcam's Antibodies, Kits and Proteins for HSP90AA1
	Custom Antibody / Protein Production Service
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	Abcam protocols and scientific support

Recombinant Protein for HSP90AA1

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for HSP90AA1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSP90AA1

	SwitchGear 3'UTR luciferase reporter plasmids for HSP90AA1
	SwitchGear Promoter luciferase reporter plasmids for HSP90AA1

ThermoFisher Antibody for HSP90AA1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSP90AA1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

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HSP90AA1 Gene

heat shock protein 90kDa alpha (cytosolic), class A member...

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HSP90AA1 (Gene Symbol)
Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1
HSPC1
HSPCA
HSP90A
HSP90N
Hsp89
Hsp90
Heat Shock 90kD Protein 1, Alpha
Heat Shock 90kDa Protein 1, Alpha
Heat Shock 86 KDa
Renal Carcinoma Antigen NY-REN-38
HSP86
HSP 86
HSP89A
HSPCAL4
LAP2
FLJ31884
EL52
HSPCAL1
HSPN
Epididymis Luminal Secretory Protein 52
Heat Shock 90kD Protein 1, Alpha-Like 4
Heat Shock 90kD Protein, Alpha-Like 4
Heat Shock Protein HSP 90-Alpha

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LEUKAEMIA LYMPHOCYTIC
Lupus Erythematosus Systemic

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HSP90AA1 Gene

heat shock protein 90kDa alpha (cytosolic), class A member...

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