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Aliases for HSP90AA1 Gene

Aliases for HSP90AA1 Gene

  • Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1 2 3
  • Lipopolysaccharide-Associated Protein 2 3 4
  • Heat Shock 90kDa Protein 1, Alpha 2 3
  • Renal Carcinoma Antigen NY-REN-38 3 4
  • Heat Shock 90kD Protein 1, Alpha 2 3
  • LPS-Associated Protein 2 3 4
  • Heat Shock 86 KDa 3 4
  • HSP 86 3 4
  • HSP90A 3 4
  • HSPCA 3 4
  • HSPC1 3 4
  • HSP86 3 4
  • LAP-2 3 4
  • Epididymis Luminal Secretory Protein 52 3
  • Heat Shock 90kD Protein 1, Alpha-Like 4 3
  • Heat Shock 90kD Protein, Alpha-Like 4 3
  • HSPCAL1 3
  • HSPCAL4 3
  • HSP89A 3
  • HSP90N 3
  • Hsp89 3
  • Hsp90 3
  • LAP2 3
  • EL52 3
  • HSPN 3

External Ids for HSP90AA1 Gene

Previous HGNC Symbols for HSP90AA1 Gene

  • HSPC1
  • HSPCA

Previous GeneCards Identifiers for HSP90AA1 Gene

  • GC14M101619
  • GC14M102547

Summaries for HSP90AA1 Gene

Entrez Gene Summary for HSP90AA1 Gene

  • The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for HSP90AA1 Gene

HSP90AA1 (Heat Shock Protein 90kDa Alpha (Cytosolic), Class A Member 1) is a Protein Coding gene. Diseases associated with HSP90AA1 include small cell sarcoma and lobular neoplasia. Among its related pathways are PI3K-Akt signaling pathway and Immune System. GO annotations related to this gene include poly(A) RNA binding and identical protein binding. An important paralog of this gene is HSP90AB1.

UniProtKB/Swiss-Prot for HSP90AA1 Gene

  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Tocris Summary for HSP90AA1 Gene

  • Hsp90 (90 kDa heat shock protein) is a molecular chaperone that aids protein folding and quality control for a large number of 'client' proteins. Hsp90 operates as dimer and has intrinsic ATPase activity. The Hsp90 dimer acts in concert with other chaperones (e.g. Hsp70).

Gene Wiki entry for HSP90AA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSP90AA1 Gene

Genomics for HSP90AA1 Gene

Regulatory Elements for HSP90AA1 Gene

Transcription factor binding sites by QIAGEN in the HSP90AA1 gene promoter:

Genomic Location for HSP90AA1 Gene

Chromosome:
14
Start:
102,080,738 bp from pter
End:
102,139,759 bp from pter
Size:
59,022 bases
Orientation:
Minus strand

Genomic View for HSP90AA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSP90AA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSP90AA1 Gene

Proteins for HSP90AA1 Gene

  • Protein details for HSP90AA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07900-HS90A_HUMAN
    Recommended name:
    Heat shock protein HSP 90-alpha
    Protein Accession:
    P07900
    Secondary Accessions:
    • A8K500
    • B3KPJ9
    • Q2PP14
    • Q5CAQ6
    • Q5CAQ7
    • Q9BVQ5

    Protein attributes for HSP90AA1 Gene

    Size:
    732 amino acids
    Molecular mass:
    84660 Da
    Quaternary structure:
    • Homodimer. Identified in NR3C1/GCR steroid receptor-chaperone complexes formed at least by NR3C1, HSP90AA1 and a variety of proteins containing TPR repeats such as FKBP4, FKBP5, PPID, PPP5C STIP1. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems. Interacts (via TPR repeat-binding motif) with PPP5C (via TPR repeats); the interaction is direct and activates PPP5C phosphatase activity. Following LPS binding, may form a complex with CXCR4, GDF5 and HSPA8. May interact with NWD1 (PubMed:24681825).

    Three dimensional structures from OCA and Proteopedia for HSP90AA1 Gene

    Alternative splice isoforms for HSP90AA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSP90AA1 Gene

Proteomics data for HSP90AA1 Gene at MOPED

Post-translational modifications for HSP90AA1 Gene

  • ISGylated.
  • S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.
  • Ubiquitination at Lys 84, Lys 294, Lys 314, Lys 419, Lys 436, Lys 446, Lys 478, and Lys 513
  • Modification sites at PhosphoSitePlus

Other Protein References for HSP90AA1 Gene

Antibody Products

  • R&D Systems Antibodies for HSP90AA1 (HSP90 alpha)
  • Cell Signaling Technology (CST) Antibodies for HSP90AA1 (HSP90A)

No data available for DME Specific Peptides for HSP90AA1 Gene

Domains & Families for HSP90AA1 Gene

Gene Families for HSP90AA1 Gene

Suggested Antigen Peptide Sequences for HSP90AA1 Gene

Graphical View of Domain Structure for InterPro Entry

P07900

UniProtKB/Swiss-Prot:

HS90A_HUMAN :
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1
  • Belongs to the heat shock protein 90 family.
Domain:
  • The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with HSP90AA1: view

Function for HSP90AA1 Gene

Molecular function for HSP90AA1 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Gene Ontology (GO) - Molecular Function for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 11470816
GO:0005515 protein binding IPI 9660753
GO:0005524 ATP binding TAS 11470816
GO:0016887 ATPase activity IDA 15937123
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with HSP90AA1: view
genes like me logo Genes that share phenotypes with HSP90AA1: view

Animal Models for HSP90AA1 Gene

MGI Knock Outs for HSP90AA1:

miRNA for HSP90AA1 Gene

miRTarBase miRNAs that target HSP90AA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HSP90AA1 Gene

Localization for HSP90AA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Cytoplasm. Melanosome. Cell membrane. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSP90AA1 Gene COMPARTMENTS Subcellular localization image for HSP90AA1 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
plasma membrane 5
chloroplast 2
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
mitochondrion 2
vacuole 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular --
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with HSP90AA1: view

Pathways & Interactions for HSP90AA1 Gene

genes like me logo Genes that share pathways with HSP90AA1: view

PCR Array Products

SIGNOR curated interactions for HSP90AA1 Gene

Activates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for HSP90AA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006457 protein folding --
GO:0006839 mitochondrial transport TAS 12526792
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with HSP90AA1: view

Drugs & Compounds for HSP90AA1 Gene

(136) Drugs for HSP90AA1 Gene - From: NovoSeek, DGIdb, DrugBank, ApexBio, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rifabutin Approved Pharma Target, other/unknown 52
Nedocromil Approved Pharma Target 5
Amphotericin B Approved, Investigational Pharma 114
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Bortezomib Approved, Experimental, Investigational Pharma Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758

(52) Additional Compounds for HSP90AA1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
17-AAG
75747-14-7
17-DMAG hydrochloride
467214-21-7
Macbecin I
73341-72-7
17-(allylamino)-17-demethoxygeldanamycin
17-amino-17-demethoxygeldanamycin
genes like me logo Genes that share compounds with HSP90AA1: view

Transcripts for HSP90AA1 Gene

Unigene Clusters for HSP90AA1 Gene

Heat shock protein 90kDa alpha (cytosolic), class A member 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSP90AA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:
SP6: - -
SP7: - - - - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HSP90AA1 Gene

GeneLoc Exon Structure for
HSP90AA1
ECgene alternative splicing isoforms for
HSP90AA1

Expression for HSP90AA1 Gene

mRNA expression in normal human tissues for HSP90AA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HSP90AA1 Gene

This gene is overexpressed in Lymph node (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSP90AA1 Gene



SOURCE GeneReport for Unigene cluster for HSP90AA1 Gene Hs.525600

genes like me logo Genes that share expression patterns with HSP90AA1: view

Protein tissue co-expression partners for HSP90AA1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSP90AA1 Gene

Orthologs for HSP90AA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSP90AA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSP90AA1 35
  • 88.62 (n)
  • 98.36 (a)
HSP90AA1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90AA1 35
  • 87.47 (n)
  • 97.77 (a)
HSP90AA1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90aa1 35
  • 90.12 (n)
  • 98.77 (a)
Hsp90aa1 16
Hsp90aa1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSP90AA1 35
  • 99.18 (n)
  • 99.45 (a)
HSP90AA1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsp90aa1 35
  • 90.89 (n)
  • 98.91 (a)
oppossum
(Monodelphis domestica)
Mammalia HSP90AA1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90AA1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSP90AA1 35
  • 82.01 (n)
  • 95.6 (a)
HSP90AA1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90AA1 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsp90aa1.1 35
  • 79.83 (n)
  • 93.26 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
hsp90aa1.2 35
  • 77.44 (n)
  • 90.96 (a)
hsp90aa1.2 36
  • 90 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hsp83 36
  • 78 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-21 36
  • 77 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSP82 36
  • 61 (a)
OneToMany
HSC82 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HSP81-2 35
  • 67.96 (n)
  • 71.47 (a)
rice
(Oryza sativa)
Liliopsida Os09g0482100 35
  • 66.43 (n)
  • 71.65 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3846 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11103 36
  • 79 (a)
OneToMany
Species with no ortholog for HSP90AA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSP90AA1 Gene

ENSEMBL:
Gene Tree for HSP90AA1 (if available)
TreeFam:
Gene Tree for HSP90AA1 (if available)

Paralogs for HSP90AA1 Gene

Paralogs for HSP90AA1 Gene

genes like me logo Genes that share paralogs with HSP90AA1: view

Variants for HSP90AA1 Gene

Sequence variations from dbSNP and Humsavar for HSP90AA1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4947 -- 102,084,466(-) AACAA(C/T)ATCAA reference, synonymous-codon
rs745313 -- 102,116,780(+) caatg(A/G)ggctg intron-variant
rs1058078 -- 102,081,311(-) CTTTT(C/T)GAACT utr-variant-3-prime
rs1059623 -- 102,080,881(-) GCACA(C/T)GTAGG utr-variant-3-prime, downstream-variant-500B
rs1059629 -- 102,080,768(-) CTGTG(C/T)TAAAT utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSP90AA1 Gene

Variant ID Type Subtype PubMed ID
dgv25n68 CNV Loss 17160897
nsv832879 CNV Loss 17160897
nsv1428 CNV Insertion 18451855
esv2670326 CNV Deletion 23128226
esv25342 CNV Loss 19812545

Variation tolerance for HSP90AA1 Gene

Residual Variation Intolerance Score: 3.25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSP90AA1 Gene

HapMap Linkage Disequilibrium report
HSP90AA1
Human Gene Mutation Database (HGMD)
HSP90AA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSP90AA1 Gene

Disorders for HSP90AA1 Gene

MalaCards: The human disease database

(24) MalaCards diseases for HSP90AA1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
small cell sarcoma
  • sarcoma, small cell
lobular neoplasia
  • lobular intraepithelial neoplasia
hypersensitivity vasculitis
  • leukocytoclastic angiitis
hypersensitivity reaction type iii disease
  • immune complex disease
spinal and bulbar muscular atrophy of kennedy
  • kennedy's disease
- elite association

Relevant External Links for HSP90AA1

Genetic Association Database (GAD)
HSP90AA1
Human Genome Epidemiology (HuGE) Navigator
HSP90AA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSP90AA1
genes like me logo Genes that share disorders with HSP90AA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSP90AA1 Gene

Publications for HSP90AA1 Gene

  1. Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanox. (PMID: 12803546) Okada M. … Kobayashi R. (Biochem. J. 2003) 23 25 26 67
  2. Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. (PMID: 11306472) MA1nster P.N. … Rosen N. (Cancer Res. 2001) 23 25 26 67
  3. Inhibition of Hsp90 function by ansamycins causes retinoblastoma gene product-dependent G1 arrest. (PMID: 10919672) Srethapakdi M. … Rosen N. (Cancer Res. 2000) 23 25 26 67
  4. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. (PMID: 19662650) Yin X. … Shores C.G. (Int. J. Cancer 2010) 23 67
  5. Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. (PMID: 19739131) Matthews S.B. … Holzbeierlein J.M. (Prostate 2010) 23 67

Products for HSP90AA1 Gene

Sources for HSP90AA1 Gene

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