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Aliases for HSH2D Gene

Aliases for HSH2D Gene

  • Hematopoietic SH2 Domain Containing 2 3
  • Adaptor In Lymphocytes Of Unknown Function X 3 4
  • ALX 3 4
  • Hematopoietic SH2 Domain-Containing Protein 3
  • Hematopoietic SH2 Protein 4
  • HSH2 3

External Ids for HSH2D Gene

Previous GeneCards Identifiers for HSH2D Gene

  • GC19P016106
  • GC19P016107
  • GC19P015938
  • GC19P016244
  • GC19P015815

Summaries for HSH2D Gene

Entrez Gene Summary for HSH2D Gene

  • T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HSH2D Gene

HSH2D (Hematopoietic SH2 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HSH2D Gene

  • May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSH2D Gene

Genomics for HSH2D Gene

Regulatory Elements for HSH2D Gene

Genomic Location for HSH2D Gene

Start:
16,134,028 bp from pter
End:
16,158,575 bp from pter
Size:
24,548 bases
Orientation:
Plus strand

Genomic View for HSH2D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSH2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSH2D Gene

Proteins for HSH2D Gene

  • Protein details for HSH2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JZ2-HSH2D_HUMAN
    Recommended name:
    Hematopoietic SH2 domain-containing protein
    Protein Accession:
    Q96JZ2
    Secondary Accessions:
    • B5ME72
    • Q6ZNG7

    Protein attributes for HSH2D Gene

    Size:
    352 amino acids
    Molecular mass:
    39002 Da
    Quaternary structure:
    • Interacts with FES and TNK2.

    Three dimensional structures from OCA and Proteopedia for HSH2D Gene

    Alternative splice isoforms for HSH2D Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSH2D Gene

Proteomics data for HSH2D Gene at MOPED

Post-translational modifications for HSH2D Gene

Antibody Products

No data available for DME Specific Peptides for HSH2D Gene

Domains for HSH2D Gene

Gene Families for HSH2D Gene

HGNC:
  • SH2D :SH2 domain containing

Protein Domains for HSH2D Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HSH2D Gene

Graphical View of Domain Structure for InterPro Entry

Q96JZ2

UniProtKB/Swiss-Prot:

HSH2D_HUMAN :
  • Q96JZ2
Domain:
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with HSH2D: view

Function for HSH2D Gene

Molecular function for HSH2D Gene

UniProtKB/Swiss-Prot Function:
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.

Gene Ontology (GO) - Molecular Function for HSH2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity IEA --
GO:0005515 protein binding IPI 24728074
genes like me logo Genes that share ontologies with HSH2D: view

Phenotypes for HSH2D Gene

genes like me logo Genes that share phenotypes with HSH2D: view

Animal Models for HSH2D Gene

MGI Knock Outs for HSH2D:

Animal Model Products

CRISPR Products

miRNA for HSH2D Gene

miRTarBase miRNAs that target HSH2D

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSH2D

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSH2D Gene

Localization for HSH2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSH2D Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSH2D Gene COMPARTMENTS Subcellular localization image for HSH2D gene
Compartment Confidence
nucleus 5
cytosol 3
endosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSH2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with HSH2D: view

Pathways for HSH2D Gene

SuperPathways for HSH2D Gene

No Data Available

Interacting Proteins for HSH2D Gene

Selected Interacting proteins: Q96JZ2-HSH2D_HUMAN for HSH2D Gene via UniProtKB I2D

Gene Ontology (GO) - Biological Process for HSH2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002903 negative regulation of B cell apoptotic process IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0042110 T cell activation IEA --
GO:0051902 negative regulation of mitochondrial depolarization IEA --
genes like me logo Genes that share ontologies with HSH2D: view

No data available for Pathways by source for HSH2D Gene

Transcripts for HSH2D Gene

Unigene Clusters for HSH2D Gene

Hematopoietic SH2 domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSH2D

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSH2D Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b
SP1:
SP2: - - - -
SP3: - - -
SP4: - - - -
SP5: -
SP6: - -

Relevant External Links for HSH2D Gene

GeneLoc Exon Structure for
HSH2D
ECgene alternative splicing isoforms for
HSH2D

Expression for HSH2D Gene

mRNA expression in normal human tissues for HSH2D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSH2D Gene

This gene is overexpressed in Whole Blood (17.8) and Spleen (6.4).

Protein differential expression in normal tissues for HSH2D Gene

This gene is overexpressed in NK cells (30.2), Blymphocyte (30.1), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HSH2D Gene

SOURCE GeneReport for Unigene cluster for HSH2D Gene Hs.631617

mRNA Expression by UniProt/SwissProt for HSH2D Gene

Q96JZ2-HSH2D_HUMAN
Tissue specificity: Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.
genes like me logo Genes that share expressions with HSH2D: view

Expression partners for HSH2D Gene

In Situ Assay Products

Orthologs for HSH2D Gene

This gene was present in the common ancestor of mammals.

Orthologs for HSH2D Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSH2D 35
  • 74.09 (n)
  • 64.63 (a)
dog
(Canis familiaris)
Mammalia HSH2D 35
  • 74.37 (n)
  • 64.74 (a)
mouse
(Mus musculus)
Mammalia Hsh2d 35
  • 69.87 (n)
  • 61.26 (a)
Hsh2d 16
chimpanzee
(Pan troglodytes)
Mammalia HSH2D 35
  • 99.53 (n)
  • 99.15 (a)
rat
(Rattus norvegicus)
Mammalia Hsh2d 35
  • 66.77 (n)
  • 56.36 (a)
Species with no ortholog for HSH2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSH2D Gene

ENSEMBL:
Gene Tree for HSH2D (if available)
TreeFam:
Gene Tree for HSH2D (if available)

Paralogs for HSH2D Gene

Selected SIMAP similar genes for HSH2D Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with HSH2D: view

No data available for Paralogs for HSH2D Gene

Variants for HSH2D Gene

Sequence variations from dbSNP and Humsavar for HSH2D Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs106048 -- 16,153,961(-) ACACC(A/G)AGCCC intron-variant
rs111524 -- 16,154,684(-) ggtga(C/T)aggca intron-variant
rs166948 -- 16,150,641(-) tggca(C/T)gatct intron-variant
rs285286 -- 16,152,392(-) ccccc(A/C)ggctg intron-variant
rs285287 -- 16,150,871(-) TGAAT(C/T)Gtttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSH2D Gene

Variant ID Type Subtype PubMed ID
nsv911158 CNV Loss 21882294
nsv833767 CNV Loss 17160897
esv2718260 CNV Deletion 23290073
esv2718261 CNV Deletion 23290073
esv2672837 CNV Deletion 23128226

Relevant External Links for HSH2D Gene

HapMap Linkage Disequilibrium report
HSH2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSH2D Gene

Disorders for HSH2D Gene

Relevant External Links for HSH2D

Genetic Association Database (GAD)
HSH2D
Human Genome Epidemiology (HuGE) Navigator
HSH2D

No disorders were found for HSH2D Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HSH2D Gene

Publications for HSH2D Gene

  1. HSH2: a novel SH2 domain-containing adapter protein involved in tyrosine kinase signaling in hematopoietic cells. (PMID: 11700021) Oda T. … Yamashita T. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Cloning and characterization of ALX, an adaptor downstream of CD28. (PMID: 12960172) Greene T.A. … Shapiro V.S. (J. Biol. Chem. 2003) 3 4 23
  3. The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP. (PMID: 15284240) Shapiro M.J. … Shapiro V.S. (J. Biol. Chem. 2004) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HSH2D Gene

Sources for HSH2D Gene

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