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Aliases for HSFY2 Gene

Aliases for HSFY2 Gene

  • Heat Shock Transcription Factor, Y-Linked 2 2 3 5
  • Heat Shock Transcription Factor 2-Like Protein 3 4
  • HSF2L 3 4
  • HSFY 3 4
  • HSFY1 HSFY2 4
  • HSF2-Like 4

External Ids for HSFY2 Gene

Previous GeneCards Identifiers for HSFY2 Gene

  • GC0YP019605
  • GC0YM019281
  • GC0YM020893

Summaries for HSFY2 Gene

Entrez Gene Summary for HSFY2 Gene

  • This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSFY2 Gene

HSFY2 (Heat Shock Transcription Factor, Y-Linked 2) is a Protein Coding gene. Diseases associated with HSFY2 include Male Reproductive System Disease. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HSFX1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFY2 Gene

Genomics for HSFY2 Gene

Regulatory Elements for HSFY2 Gene


Genomic Location for HSFY2 Gene

Chromosome:
Y
Start:
18,731,440 bp from pter
End:
18,828,662 bp from pter
Size:
97,223 bases
Orientation:
Minus strand

Genomic View for HSFY2 Gene

Genes around HSFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFY2 Gene

Proteins for HSFY2 Gene

  • Protein details for HSFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LI6-HSFY1_HUMAN
    Recommended name:
    Heat shock transcription factor, Y-linked
    Protein Accession:
    Q96LI6
    Secondary Accessions:
    • Q17RC0
    • Q7Z4L8
    • Q9BZA2
    • Q9BZA3

    Protein attributes for HSFY2 Gene

    Size:
    401 amino acids
    Molecular mass:
    45107 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSFY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSFY2 Gene

Proteomics data for HSFY2 Gene at MOPED

Post-translational modifications for HSFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFY2 Gene

No data available for DME Specific Peptides for HSFY2 Gene

Domains & Families for HSFY2 Gene

Protein Domains for HSFY2 Gene

Suggested Antigen Peptide Sequences for HSFY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96LI6

UniProtKB/Swiss-Prot:

HSFY1_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFY2: view

No data available for Gene Families for HSFY2 Gene

Function for HSFY2 Gene

Gene Ontology (GO) - Molecular Function for HSFY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSFY2: view

Phenotypes for HSFY2 Gene

GenomeRNAi human phenotypes for HSFY2:
genes like me logo Genes that share phenotypes with HSFY2: view

Animal Model Products

miRNA for HSFY2 Gene

miRTarBase miRNAs that target HSFY2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSFY2 Gene

Localization for HSFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSFY2 Gene COMPARTMENTS Subcellular localization image for HSFY2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HSFY2 Gene

Pathways & Interactions for HSFY2 Gene

SuperPathways for HSFY2 Gene

No Data Available

Interacting Proteins for HSFY2 Gene

Gene Ontology (GO) - Biological Process for HSFY2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HSFY2 Gene

Drugs & Compounds for HSFY2 Gene

No Compound Related Data Available

Transcripts for HSFY2 Gene

Unigene Clusters for HSFY2 Gene

Heat shock transcription factor, Y linked 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSFY2 Gene

No ASD Table

Relevant External Links for HSFY2 Gene

GeneLoc Exon Structure for
HSFY2
ECgene alternative splicing isoforms for
HSFY2

Expression for HSFY2 Gene

mRNA expression in normal human tissues for HSFY2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSFY2 Gene



SOURCE GeneReport for Unigene cluster for HSFY2 Gene Hs.592255

mRNA Expression by UniProt/SwissProt for HSFY2 Gene

Q96LI6-HSFY1_HUMAN
Tissue specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).
genes like me logo Genes that share expression patterns with HSFY2: view

Protein tissue co-expression partners for HSFY2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HSFY2 Gene

Orthologs for HSFY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSFY2 35
  • 70.56 (n)
  • 54.91 (a)
-- 36
  • 45 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 44 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
HSFY2 36
  • 51 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hsfy2 35
  • 65.87 (n)
  • 47.75 (a)
Hsfy2 16
Hsfy2 36
  • 42 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hsfy2 35
  • 65.34 (n)
  • 47.75 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 22 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100859862 35
  • 56.21 (n)
  • 42.65 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
Species with no ortholog for HSFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFY2 Gene

ENSEMBL:
Gene Tree for HSFY2 (if available)
TreeFam:
Gene Tree for HSFY2 (if available)

Paralogs for HSFY2 Gene

Paralogs for HSFY2 Gene

genes like me logo Genes that share paralogs with HSFY2: view

Variants for HSFY2 Gene

Sequence variations from dbSNP and Humsavar for HSFY2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs233742 -- 18,746,142(+) TTACC(A/G)AGGCC intron-variant
rs233743 -- 18,747,358(+) tctcc(C/T)aaggc intron-variant
rs369081915 -- 18,769,967(+) ATACA(-/TG)TGTGT intron-variant
rs374664752 -- 18,759,046(+) ACACT(A/G)AAATA intron-variant
rs377416015 -- 18,770,005(+) TGTGT(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSFY2 Gene

Variant ID Type Subtype PubMed ID
esv1670141 OTHER Inversion 17803354
dgv2500e1 CNV Complex 17122850
nsv10022 CNV Gain 18304495

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for HSFY2 Gene

Disorders for HSFY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSFY2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search HSFY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSFY2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSFY2
genes like me logo Genes that share disorders with HSFY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSFY2 Gene

Publications for HSFY2 Gene

  1. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 2 3 4 67
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis. (PMID: 14985478) Tessari A. … Foresta C. (Mol. Hum. Reprod. 2004) 3

Products for HSFY2 Gene

Sources for HSFY2 Gene

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