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Aliases for HSFY1 Gene

Aliases for HSFY1 Gene

  • Heat Shock Transcription Factor, Y-Linked 1 2 3 5
  • Heat Shock Transcription Factor 2-Like Protein 3 4
  • HSF2L 3 4
  • HSFY 3 4
  • Heat Shock Transcription Factor, Y-Linked 2
  • Heat Shock Transcription Factor 2
  • HSFY1 HSFY2 4
  • Y-Linked 1 2
  • HSF2-Like 4

External Ids for HSFY1 Gene

Previous HGNC Symbols for HSFY1 Gene

  • HSFY

Previous GeneCards Identifiers for HSFY1 Gene

  • GC0YP019604
  • GC0YP019096
  • GC0YP019167
  • GC0YP020708
  • GC0YM014604

Summaries for HSFY1 Gene

Entrez Gene Summary for HSFY1 Gene

  • This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSFY1 Gene

HSFY1 (Heat Shock Transcription Factor, Y-Linked 1) is a Protein Coding gene. Diseases associated with HSFY1 include Azoospermia and Pelvic Varices. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HSFX1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFY1 Gene

Genomics for HSFY1 Gene

Regulatory Elements for HSFY1 Gene

Genomic Location for HSFY1 Gene

18,546,671 bp from pter
18,588,963 bp from pter
42,293 bases
Plus strand

Genomic View for HSFY1 Gene

Genes around HSFY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFY1 Gene

Proteins for HSFY1 Gene

  • Protein details for HSFY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, Y-linked
    Protein Accession:
    Secondary Accessions:
    • Q17RC0
    • Q7Z4L8
    • Q9BZA2
    • Q9BZA3

    Protein attributes for HSFY1 Gene

    401 amino acids
    Molecular mass:
    45107 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSFY1 Gene


neXtProt entry for HSFY1 Gene

Proteomics data for HSFY1 Gene at MOPED

Post-translational modifications for HSFY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFY1 Gene

No data available for DME Specific Peptides for HSFY1 Gene

Domains & Families for HSFY1 Gene

Protein Domains for HSFY1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFY1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for HSFY1 Gene

Function for HSFY1 Gene

Gene Ontology (GO) - Molecular Function for HSFY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HSFY1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFY1 Gene

Localization for HSFY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFY1 Gene

Subcellular locations from

Jensen Localization Image for HSFY1 Gene COMPARTMENTS Subcellular localization image for HSFY1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HSFY1 Gene

Pathways & Interactions for HSFY1 Gene

SuperPathways for HSFY1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFY1 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSFY1 Gene

Drugs & Compounds for HSFY1 Gene

No Compound Related Data Available

Transcripts for HSFY1 Gene

Unigene Clusters for HSFY1 Gene

Heat shock transcription factor, Y-linked 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSFY1 Gene

No ASD Table

Relevant External Links for HSFY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFY1 Gene

mRNA expression in normal human tissues for HSFY1 Gene

mRNA differential expression in normal tissues according to GTEx for HSFY1 Gene

This gene is overexpressed in Brain - Cortex (x6.9), Brain - Hippocampus (x5.8), Testis (x5.3), Brain - Hypothalamus (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSFY1 Gene

SOURCE GeneReport for Unigene cluster for HSFY1 Gene Hs.662281

mRNA Expression by UniProt/SwissProt for HSFY1 Gene

Tissue specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).
genes like me logo Genes that share expression patterns with HSFY1: view

Protein tissue co-expression partners for HSFY1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for HSFY1 Gene

Orthologs for HSFY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSFY2 35
  • 70.56 (n)
  • 54.91 (a)
-- 36
  • 45 (a)
-- 36
  • 42 (a)
-- 36
  • 44 (a)
-- 36
  • 45 (a)
HSFY2 36
  • 51 (a)
(Mus musculus)
Mammalia Hsfy2 35
  • 65.87 (n)
  • 47.75 (a)
Hsfy2 36
  • 42 (a)
(Rattus norvegicus)
Mammalia Hsfy2 35
  • 65.34 (n)
  • 47.75 (a)
(Canis familiaris)
Mammalia -- 36
  • 22 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
-- 36
  • 53 (a)
(Pan troglodytes)
Mammalia -- 36
  • 71 (a)
-- 36
  • 59 (a)
(Gallus gallus)
Aves LOC100859862 35
  • 56.21 (n)
  • 42.65 (a)
-- 36
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
Species with no ortholog for HSFY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFY1 Gene

Gene Tree for HSFY1 (if available)
Gene Tree for HSFY1 (if available)

Paralogs for HSFY1 Gene

Paralogs for HSFY1 Gene

genes like me logo Genes that share paralogs with HSFY1: view

Variants for HSFY1 Gene

Sequence variations from dbSNP and Humsavar for HSFY1 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs233741 -- 18,578,081(-) CCTCC(A/G)GTGTA intron-variant
rs113127496 -- 18,562,483(+) TCTAA(A/C)AGTTA intron-variant
rs113411234 -- 18,554,971(+) GAAAC(A/C)CCATC intron-variant
rs377142238 -- 18,561,357(+) TATTT(C/T)AGTGT intron-variant
rs550039266 -- 18,557,549(+) GTGTT(A/G)TGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSFY1 Gene

Variant ID Type Subtype PubMed ID
esv1670141 OTHER Inversion 17803354
dgv2500e1 CNV Complex 17122850
nsv10022 CNV Gain 18304495

Relevant External Links for HSFY1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSFY1 Gene

Disorders for HSFY1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HSFY1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • spermatogenic failure
pelvic varices
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search HSFY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSFY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSFY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSFY1 Gene

Publications for HSFY1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. (PMID: 22158087) Kichine E. … Mitchell M.J. (Hum. Reprod. 2012) 3

Products for HSFY1 Gene

Sources for HSFY1 Gene