HSFY1 Gene
protein-coding GIFtS: 43
GCID: GC0YP020708
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heat shock transcription factor, Y-linked 1(Previous names: heat shock transcription factor, Y-linked )
(Previous symbol: HSFY)
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Aliases
for HSFY1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Heat Shock Transcription Factor, Y-Linked 11 2 | | HSFY1 2 3 5 | | HSF2L1 2 3 | | Heat Shock Transcription Factor, Y-Linked1 2 | | Heat Shock Transcription Factor 2-Like Protein2 3 | | HSF2-Like1 |
| External Ids: | HGNC: 185681 | Entrez Gene: 866142 | Ensembl: ENSG000001724687 | OMIM: 4000295 | UniProtKB: Q96LI63 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n406119 | |
Export aliases for HSFY1 gene to outside databasesPrevious GC identifers: GC0YP019604 GC0YP019096 GC0YP019167 GC0YM014604
Summaries
for HSFY1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HSFY1:
This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins.This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimesdeleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this recordrepresents the more centromeric copy. Alternative splicing results in multiple transcript variants encoding distinctisoforms. (provided by RefSeq, Jul 2008)
|
Genomic Views
for HSFY1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011875.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSFY1 gene promoter:
POU2F1 HOXA5 POU2F1a Sox9 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSFY1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSFY1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11.222 Ensembl cytogenetic band: Yq11.222 HGNC cytogenetic band: Yq11.221HSFY1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP020708: view genomic region
(about GC identifiers)
Start:
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20,708,557 bp from pter |
End:
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20,750,849 bp from pter |
Size:
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42,293 bases |
Orientation:
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plus strand |
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Proteins
for HSFY1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSFY1_HUMAN, Q96LI6 (See
protein sequence)Recommended Name: Heat shock transcription factor, Y-linked Size: 401 amino acids; 45107 Da
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: Q17RC0 Q7Z4L8 Q9BZA2 Q9BZA3Alternative splicing: 3 isoforms: Q96LI6-1 Q96LI6-2 Q96LI6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HSFY1: NX_Q96LI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96LI6
HSFY1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_149099.2 NP_689797.1
ENSEMBL proteins: ENSP00000303599 ENSP00000311166 ENSP00000342302 ENSP00000372307
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HSFY1 for ontologies About GeneDecksing
HSFY1 Antibody Products:
Assay Products for HSFY1: |
Protein
Domains /
Families
for HSFY1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSFY1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96LI6ProtoNet protein and cluster: Q96LI6 1 Blocks protein family: IPB000232 Heat shock factor (HSF)-type DNA-binding domain
UniProtKB/Swiss-Prot: HSFY1_HUMAN, Q96LI6Similarity: Belongs to the HSF family |
Function
for HSFY1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for HSFY1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSFY1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSFY1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFY1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
-- | -- | | GO:0043565 | sequence-specific DNA binding |
-- | -- |
HSFY1 for ontologies About GeneDecksing
|
Pathways & Interactions
for HSFY1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSFY1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
-- | -- |
HSFY1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSFY1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSFY1
Search CenterWatch for drugs/clinical trials and news about HSFY1
|
Transcripts
for HSFY1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSFY1 gene (3 alternative transcripts): NM_033108.2 NM_152584.1 NM_001001871.1 Unigene Cluster for HSFY1: Heat shock transcription factor, Y-linked 1 Hs.662281 [show with all ESTs]Unigene Representative Sequence: AJ5664044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307393(uc004ftp.3) ENST00000309834(uc004ftr.3) ENST00000338876(uc004ftq.3)
ENST00000382856
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for HSFY1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSFY1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSFY1 |
Additional cDNA sequence: AF332226.1 AF332227.1 AJ566404.1 BC036567.2 BC055414.1 BC117380.1 BC117382.1 NR_003510.1 10 DOTS entries: DT.120654312 DT.305740 DT.65287443 DT.120651887 DT.101977328 DT.92417462 DT.101964401 DT.120651844 DT.100664120 DT.120654306 24/32 AceView cDNA sequences (see all 32): BC036567 BC062752 NM_001001871 AJ566404 NM_153716 BG182068 AK058182 AI469188 NM_001001878 NM_152584 AF332226 NM_001001877 NM_033108 AF332227 BC055414 BG718772 AI221709 BG202229 BU569236 AI798750 AA394010 BG772904 BF980144 BF672674
GeneLoc Exon Structure
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Expression
for HSFY1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSFY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTACCAGCAG
About this image
See HSFY1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSFY1
SOURCE GeneReport for Unigene cluster: Hs.662281
UniProtKB/Swiss-Prot: HSFY1_HUMAN, Q96LI6Tissue specificity: Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level)
SABiosciences Custom PCR Arrays for HSFY1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSFY1
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HSFY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSFY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSFY1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFY1 |
Orthologs
for HSFY1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HSFY1 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BS00_CHICK6F1NP01_CHICK6 |
Uncharacterized protein |
38(a)28(a) |
many ↔ manymany ↔ many |
1(70500859-70502326) 1(71995193-71996683) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
40(a) |
possible ortholog |
GL343310.1(1056810-1061875) |
ENSEMBL Gene Tree for HSFY1 (if available)
TreeFam Gene Tree for HSFY1 (if available) |
Paralogs
for HSFY1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HSFY1 gene
- HSFY21 2 HSFX22 HSFX12
HSFY1 for paralogs About GeneDecksing
5/8 Pseudogenes.org Pseudogenes for HSFY1 (see all 8)
PGOHUM00000246384 PGOHUM00000233662 PGOHUM00000233785 PGOHUM00000233790 PGOHUM00000233808
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Genomic Variants
for HSFY1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSFY1
1 CNV: 4183
Human Gene Mutation Database (HGMD): HSFY1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HSFY1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSFY1 for disorders About GeneDecksing
OMIM gene information: 400029
OMIM disorders: --
4  diseases for HSFY1: About MalaCardsinfertility azoospermia y chromosome infertility male infertility
2 diseases from the University of Copenhagen DISEASES database for HSFY1:Azoospermia Sertoli cell-only syndrome GeneTests: HSFY1
Y Chromosome Infertility
Export disorders for HSFY1 gene to outside databases
|
Publications
for HSFY1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSFY1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSFY1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PubMed id 15044259)1, 2 Shinka T.... Nakahori Y. (2004)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- HSFY genes and the P4 palindrome in the AZFb interval of the human Y chromosome are not required for spermatocyte maturation. (PubMed id 22158087)1 Kichine E....Mitchell M.J. (2012)
- Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstr uctive azoospermia. (PubMed id 22820855)1 Stahl P.J....Paduch D.A. (2012)
- Characterization of HSFY, a novel AZFb gene on the Y chromosome with a possible role in human spermatogenesis. (PubMed id 14985478)1 Tessari A....Foresta C. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Y Chromosome Infertility (PubMed id 20301513)1 Disteche C.M. (1993)
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External Searches for HSFY1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSFY1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSFY1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSFY1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSFY1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/HSFY1 |
|
| | |
About This Section
| Patent Information for HSFY1 gene:
Search GeneIP for patents involving HSFY1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSFY1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HSFY1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSFY1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSFY1 | | | OriGene Protein Over-expression Lysate for HSFY1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSFY1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSFY1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSFY1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSFY1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSFY1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSFY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSFY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSFY1 |
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 |  |  |  | |
| | | | Search Tocris compounds for HSFY1 |
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 | | | HSFY1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFY1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HSFY1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSFY1 |
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