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Aliases for HSFX2 Gene

Aliases for HSFX2 Gene

  • Heat Shock Transcription Factor Family, X-Linked 2 2 3 5
  • HSFX1 HSFX2 4
  • LW-1 4

External Ids for HSFX2 Gene

Previous GeneCards Identifiers for HSFX2 Gene

  • GC0XU900657
  • GC0XP148663
  • GC0XM148483
  • GC0XM148674

Summaries for HSFX2 Gene

GeneCards Summary for HSFX2 Gene

HSFX2 (Heat Shock Transcription Factor Family, X-Linked 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFX1.

Additional gene information for HSFX2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFX2 Gene

Genomics for HSFX2 Gene

GeneHancer (GH) Regulatory Elements for HSFX2 Gene

Promoters and enhancers for HSFX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI149594 Promoter 0.5 EPDnew 550.8 +0.6 568 0.1 HSFX2 MAGEA9B
GH0XI149630 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.3 -35.9 -35922 2.3 RB1 SIN3A ZNF335 GLIS2 EGR1 SMARCA5 SP3 ZBTB11 ELF1 GLIS1 TMEM185A CXorf40A IDS HSFX2
GH0XI149627 Enhancer 0.6 ENCODE 0.3 -33.1 -33141 1 FOXA2 RFX1 TEAD1 RARA TEAD3 SKI NR2F6 SMAD4 RXRB TMEM185A HSFX2
GH0XI149603 Enhancer 0.2 FANTOM5 0.4 -7.9 -7946 0.4 HSFX2 TMEM185A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HSFX2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HSFX2 gene promoter:

Genomic Locations for HSFX2 Gene

Genomic Locations for HSFX2 Gene
chrX:149,592,512-149,595,310
(GRCh38/hg38)
Size:
2,799 bases
Orientation:
Minus strand
chrX:148,674,172-148,676,974
(GRCh37/hg19)

Genomic View for HSFX2 Gene

Genes around HSFX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX2 Gene

Proteins for HSFX2 Gene

  • Protein details for HSFX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD0-HSFX1_HUMAN
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:
    Q9UBD0

    Protein attributes for HSFX2 Gene

    Size:
    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX2 Gene

Post-translational modifications for HSFX2 Gene

No Post-translational modifications

Other Protein References for HSFX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX2 Gene

Domains & Families for HSFX2 Gene

Gene Families for HSFX2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSFX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBD0

UniProtKB/Swiss-Prot:

HSFX1_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFX2: view

Function for HSFX2 Gene

Gene Ontology (GO) - Molecular Function for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16713569
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFX2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFX2 Gene

Localization for HSFX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSFX2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSFX2 Gene

Pathways & Interactions for HSFX2 Gene

SuperPathways for HSFX2 Gene

No Data Available

Interacting Proteins for HSFX2 Gene

Gene Ontology (GO) - Biological Process for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Pathways by source and SIGNOR curated interactions for HSFX2 Gene

Drugs & Compounds for HSFX2 Gene

No Compound Related Data Available

Transcripts for HSFX2 Gene

mRNA/cDNA for HSFX2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX2 Gene

No ASD Table

Relevant External Links for HSFX2 Gene

GeneLoc Exon Structure for
HSFX2
ECgene alternative splicing isoforms for
HSFX2

Expression for HSFX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSFX2 Gene

Protein differential expression in normal tissues from HIPED for HSFX2 Gene

This gene is overexpressed in Plasma (37.3) and Monocytes (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSFX2 Gene



Protein tissue co-expression partners for HSFX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HSFX2 Gene:

HSFX2

mRNA Expression by UniProt/SwissProt for HSFX2 Gene:

Q9UBD0-HSFX1_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with HSFX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSFX2 Gene

Orthologs for HSFX2 Gene

Evolution for HSFX2 Gene

ENSEMBL:
Gene Tree for HSFX2 (if available)
TreeFam:
Gene Tree for HSFX2 (if available)

No data available for Orthologs for HSFX2 Gene

Paralogs for HSFX2 Gene

Paralogs for HSFX2 Gene

(1) SIMAP similar genes for HSFX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSFX2: view

Variants for HSFX2 Gene

Sequence variations from dbSNP and Humsavar for HSFX2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs142482822 -- 149,597,147(-) A/G upstream_transcript_variant
rs147716632 -- 149,597,142(-) G/C upstream_transcript_variant
rs186408209 -- 149,596,413(-) T/C upstream_transcript_variant
rs200049366 -- 149,593,104(-) G/A coding_sequence_variant, missense_variant
rs201414118 -- 149,592,181(-) G/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HSFX2 Gene

Variant ID Type Subtype PubMed ID
esv3577504 CNV gain 25503493
esv3577518 CNV gain 25503493
esv3577519 CNV gain 25503493
nsv1149848 CNV duplication 26484159
nsv508809 CNV insertion 20534489
nsv518742 CNV gain 19592680
nsv525908 CNV gain 19592680
nsv7464 OTHER inversion 18451855
nsv818041 CNV gain 17921354

Additional Variant Information for HSFX2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSFX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HSFX2 Gene

Disorders for HSFX2 Gene

Additional Disease Information for HSFX2

No disorders were found for HSFX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSFX2 Gene

Publications for HSFX2 Gene

  1. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T … Nakahori Y (Biology of reproduction 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 58
  4. No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes. (PMID: 23094017) Katsura Y … Satta Y (PloS one 2012) 3 58
  5. In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PMID: 20388717) Blomster HA … Sistonen L (The Journal of biological chemistry 2010) 4 58

Products for HSFX2 Gene

Sources for HSFX2 Gene

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