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Aliases for HSFX2 Gene

Aliases for HSFX2 Gene

  • Heat Shock Transcription Factor Family, X Linked 2 2 3
  • HSFX1 HSFX2 4
  • LW-1 4

External Ids for HSFX2 Gene

Summaries for HSFX2 Gene

GeneCards Summary for HSFX2 Gene

HSFX2 (Heat Shock Transcription Factor Family, X Linked 2) is a Protein Coding gene. An important paralog of this gene is HSFX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFX2 Gene

Genomics for HSFX2 Gene

Genomic Location for HSFX2 Gene

Start:
149,592,512 bp from pter
End:
149,595,310 bp from pter
Size:
2,799 bases
Orientation:
Minus strand

Genomic View for HSFX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSFX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX2 Gene

Regulatory Elements for HSFX2 Gene

Proteins for HSFX2 Gene

  • Protein details for HSFX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBD0-HSFX1_HUMAN
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:
    Q9UBD0
    Secondary Accessions:

    Protein attributes for HSFX2 Gene

    Size:
    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX2 Gene

Proteomics data for HSFX2 Gene at MOPED

Post-translational modifications for HSFX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX2 Gene

Domains for HSFX2 Gene

Protein Domains for HSFX2 Gene

Suggested Antigen Peptide Sequences for HSFX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UBD0

UniProtKB/Swiss-Prot:

HSFX1_HUMAN
Family:
  • Belongs to the HSF family.:
    • Q9UBD0
genes like me logo Genes that share domains with HSFX2: view

No data available for Gene Families for HSFX2 Gene

Function for HSFX2 Gene

Gene Ontology (GO) - Molecular Function for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16713569
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSFX2 Gene

Localization for HSFX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSFX2 Gene COMPARTMENTS Subcellular localization image for HSFX2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFX2: view

Pathways for HSFX2 Gene

SuperPathways for HSFX2 Gene

No Data Available

Interacting Proteins for HSFX2 Gene

Gene Ontology (GO) - Biological Process for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFX2: view

No data available for Pathways by source for HSFX2 Gene

Transcripts for HSFX2 Gene

mRNA/cDNA for HSFX2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX2 Gene

No ASD Table

Relevant External Links for HSFX2 Gene

GeneLoc Exon Structure for
HSFX2
ECgene alternative splicing isoforms for
HSFX2

Expression for HSFX2 Gene

mRNA expression in normal human tissues for HSFX2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HSFX2 Gene

mRNA Expression by UniProt/SwissProt for HSFX2 Gene

Q9UBD0-HSFX1_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with HSFX2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSFX2 Gene

Orthologs for HSFX2 Gene

Evolution for HSFX2 Gene

ENSEMBL:
Gene Tree for HSFX2 (if available)
TreeFam:
Gene Tree for HSFX2 (if available)

No data available for Orthologs for HSFX2 Gene

Paralogs for HSFX2 Gene

Paralogs for HSFX2 Gene

Selected SIMAP similar genes for HSFX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSFX2: view

Variants for HSFX2 Gene

Sequence variations from dbSNP and Humsavar for HSFX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs445334 -- 149,592,232(-) TCCTG(A/G)CTAAC downstream-variant-500B
rs2071188 -- 149,594,255(-) AACTT(C/T)GATAA reference, missense
rs200049366 -- 149,593,104(+) TTGCG(A/G)TGTGA reference, missense
rs200199452 -- 149,594,647(+) TGTCC(C/T)CTCGA synonymous-codon, reference
rs201414118 -- 149,592,181(+) GCCAC(G/T)CCCGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSFX2 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489
nsv818041 CNV Gain 17921354

Relevant External Links for HSFX2 Gene

HapMap Linkage Disequilibrium report
HSFX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSFX2 Gene

Disorders for HSFX2 Gene

No disorders were found for HSFX2 Gene.

No data available for UniProtKB/Swiss-Prot for HSFX2 Gene

Publications for HSFX2 Gene

  1. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T. … Nakahori Y. (Biol. Reprod. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  4. No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes. (PMID: 23094017) Katsura Y. … Satta Y. (PLoS ONE 2012) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for HSFX2 Gene

Sources for HSFX2 Gene

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