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Aliases for HSFX2 Gene

Aliases for HSFX2 Gene

  • Heat Shock Transcription Factor Family, X-Linked 2 2 3 5
  • HSFX1 HSFX2 4
  • LW-1 4

External Ids for HSFX2 Gene

Previous GeneCards Identifiers for HSFX2 Gene

  • GC0XU900657
  • GC0XP148663
  • GC0XM148483
  • GC0XM148674

Summaries for HSFX2 Gene

GeneCards Summary for HSFX2 Gene

HSFX2 (Heat Shock Transcription Factor Family, X-Linked 2) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HSFX1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFX2 Gene

Genomics for HSFX2 Gene

Regulatory Elements for HSFX2 Gene

Enhancers for HSFX2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSFX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSFX2 Gene

149,592,512 bp from pter
149,595,310 bp from pter
2,799 bases
Minus strand

Genomic View for HSFX2 Gene

Genes around HSFX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSFX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSFX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX2 Gene

Proteins for HSFX2 Gene

  • Protein details for HSFX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:

    Protein attributes for HSFX2 Gene

    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX2 Gene

Proteomics data for HSFX2 Gene at MOPED

Post-translational modifications for HSFX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX2 Gene

Domains & Families for HSFX2 Gene

Protein Domains for HSFX2 Gene

Suggested Antigen Peptide Sequences for HSFX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFX2: view

No data available for Gene Families for HSFX2 Gene

Function for HSFX2 Gene

Gene Ontology (GO) - Molecular Function for HSFX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16713569
genes like me logo Genes that share ontologies with HSFX2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HSFX2 Gene

Localization for HSFX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX2 Gene

Subcellular locations from

Jensen Localization Image for HSFX2 Gene COMPARTMENTS Subcellular localization image for HSFX2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HSFX2 Gene

Pathways & Interactions for HSFX2 Gene

SuperPathways for HSFX2 Gene

No Data Available

Interacting Proteins for HSFX2 Gene

Gene Ontology (GO) - Biological Process for HSFX2 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSFX2 Gene

Drugs & Compounds for HSFX2 Gene

No Compound Related Data Available

Transcripts for HSFX2 Gene

mRNA/cDNA for HSFX2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX2 Gene

No ASD Table

Relevant External Links for HSFX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFX2 Gene

mRNA expression in normal human tissues for HSFX2 Gene

Protein differential expression in normal tissues from HIPED for HSFX2 Gene

This gene is overexpressed in Plasma (37.3) and Monocytes (31.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HSFX2 Gene

mRNA Expression by UniProt/SwissProt for HSFX2 Gene

Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with HSFX2: view

Protein tissue co-expression partners for HSFX2 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSFX2 Gene

Orthologs for HSFX2 Gene

Evolution for HSFX2 Gene

Gene Tree for HSFX2 (if available)
Gene Tree for HSFX2 (if available)

No data available for Orthologs for HSFX2 Gene

Paralogs for HSFX2 Gene

Paralogs for HSFX2 Gene

(1) SIMAP similar genes for HSFX2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSFX2: view

Variants for HSFX2 Gene

Sequence variations from dbSNP and Humsavar for HSFX2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs445334 -- 149,592,232(-) TCCTG(A/G)CTAAC downstream-variant-500B
rs2071187 -- 149,594,647(-) TCGAG(A/G)GGACA reference, synonymous-codon
rs2071188 -- 149,594,255(-) AACTT(C/T)GATAA reference, missense
rs5980489 -- 149,592,348(-) GAGTA(A/C/G/T)AGGCG downstream-variant-500B
rs200049366 -- 149,593,104(+) TTGCG(A/G)TGTGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HSFX2 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489
nsv818041 CNV Gain 17921354

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for HSFX2 Gene

Disorders for HSFX2 Gene

Relevant External Links for HSFX2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HSFX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSFX2 Gene

Publications for HSFX2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  3. No evidence for a second evolutionary stratum during the early evolution of mammalian sex chromosomes. (PMID: 23094017) Katsura Y. … Satta Y. (PLoS ONE 2012) 3
  4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3
  5. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T. … Nakahori Y. (Biol. Reprod. 2004) 3

Products for HSFX2 Gene

Sources for HSFX2 Gene