HSFX1 Gene
protein-coding GIFtS: 45
GCID: GC0XP148855
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heat shock transcription factor family, X linked 1
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Aliases
for HSFX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heat Shock Transcription Factor Family, X Linked 11 2 | | LW-11 2 3 | | Heat Shock Transcription Factor, X-Linked2 |
Export aliases for HSFX1 gene to outside databasesPrevious GC identifers: GC0XM148481 GC0XP148665 |
Summaries
for HSFX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HSFX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NT_011681.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSFX1 gene promoter:
Nkx3-1 GR Pbx1a SREBP-1c GR-beta LCR-F1 HNF-3beta SREBP-1b SREBP-1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSFX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSFX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28HSFX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP148855: view genomic region
(about GC identifiers)
Start:
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148,855,726 bp from pter |
End:
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148,858,525 bp from pter |
Size:
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2,800 bases |
Orientation:
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plus strand |
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Proteins
for HSFX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSFX1_HUMAN, Q9UBD0 (See
protein sequence)Recommended Name: Heat shock transcription factor, X-linked Size: 423 amino acids; 46742 Da
Subcellular location: Nucleus (Potential). CytoplasmExplore the universe of human proteins at neXtProt for HSFX1: NX_Q9UBD0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UBD0
HSFX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057237.1
ENSEMBL proteins: ENSP00000359444
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HSFX1 for ontologies About GeneDecksing
HSFX1 Antibody Products:
Assay Products for HSFX1: |
Protein
Domains /
Families
for HSFX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSFX1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UBD0ProtoNet protein and cluster: Q9UBD0 1 Blocks protein family: IPB000232 Heat shock factor (HSF)-type DNA-binding domain
UniProtKB/Swiss-Prot: HSFX1_HUMAN, Q9UBD0Similarity: Belongs to the HSF family |
Function
for HSFX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFX1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | 16713569 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
HSFX1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HSFX1:
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Pathways & Interactions
for HSFX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSFX1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for HSFX1 (Q9UBD01, 2, 3 ENSP000003594444) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
HSFX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSFX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSFX1
Search CenterWatch for drugs/clinical trials and news about HSFX1 
|
Transcripts
for HSFX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSFX1 gene: NM_016153.2 Unigene Clusters for HSFX1: Heat shock transcription factor family, X linked 1 Hs.656936 [show with all ESTs], Hs.709146 Unigene Representative Sequences: BC021706, AF1399801 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370416(uc022cgm.1 uc010ntb.3)
Additional cDNA sequence: AF139980.1 AK310305.1 3 DOTS entries: DT.305963 DT.97823211 DT.91710577
GeneLoc Exon Structure
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Expression
for HSFX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSFX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAGCTAGCG
About this image
See HSFX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSFX1
SOURCE GeneReport for Unigene clusters: Hs.656936 Hs.709146
UniProtKB/Swiss-Prot: HSFX1_HUMAN, Q9UBD0Tissue specificity: Testis-specific
SABiosciences Custom PCR Arrays for HSFX1
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HSFX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSFX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSFX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFX1 |
Orthologs
for HSFX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
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ENSEMBL Gene Tree for HSFX1 (if available)
TreeFam Gene Tree for HSFX1 (if available) |
Paralogs
for HSFX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HSFX1 gene
- HSFX21 2 HSFY12 HSFY22
1 SIMAP similar gene for HSFX1 using alignment to 1 protein entry: HSFX1_HUMAN:HSFX2
HSFX1 for paralogs About GeneDecksing
|
Genomic Variants
for HSFX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSFX1 (148855726 - 148858525 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HSFX1
2 CNVs: 4177 9355 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSFX1 |
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Disorders
/ Diseases
for HSFX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSFX1 for disorders About GeneDecksing
4  diseases for HSFX1: About MalaCardsmale infertility oligospermia infertility ataxia
1 disease from the University of Copenhagen DISEASES database for HSFX1:Oligospermia Export disorders for HSFX1 gene to outside databases
|
Publications
for HSFX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSFX1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSFX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PubMed id 15044259)1, 2, 3 Shinka T.... Nakahori Y. (2004)
- In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PubMed id 20388717)1, 2 Blomster H.A.... Sistonen L. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
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External Searches for HSFX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSFX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSFX1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSFX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSFX1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSFX1 gene:
Search GeneIP for patents involving HSFX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSFX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSFX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSFX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSFX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSFX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSFX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSFX1 |
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 |  |  |  | |
| | | | Search Tocris compounds for HSFX1 |
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 | | | HSFX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSFX1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HSFX1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HSFX1 |
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