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Aliases for HSFX1 Gene

Aliases for HSFX1 Gene

  • Heat Shock Transcription Factor Family, X Linked 1 2 3
  • LW-1 3 4
  • Heat Shock Transcription Factor, X-Linked 3
  • HSFX1 HSFX2 4

External Ids for HSFX1 Gene

Previous GeneCards Identifiers for HSFX1 Gene

  • GC0XM148481
  • GC0XP148665
  • GC0XP148855

Summaries for HSFX1 Gene

GeneCards Summary for HSFX1 Gene

HSFX1 (Heat Shock Transcription Factor Family, X Linked 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HSFY1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSFX1 Gene

Genomics for HSFX1 Gene

Regulatory Elements for HSFX1 Gene

Genomic Location for HSFX1 Gene

149,774,068 bp from pter
149,776,867 bp from pter
2,800 bases
Plus strand

Genomic View for HSFX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSFX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSFX1 Gene

Proteins for HSFX1 Gene

  • Protein details for HSFX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock transcription factor, X-linked
    Protein Accession:
    Secondary Accessions:

    Protein attributes for HSFX1 Gene

    423 amino acids
    Molecular mass:
    46742 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSFX1 Gene

Proteomics data for HSFX1 Gene at MOPED

Post-translational modifications for HSFX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSFX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSFX1 Gene

Domains for HSFX1 Gene

Protein Domains for HSFX1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UBD0
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSFX1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for HSFX1 Gene

Function for HSFX1 Gene

Gene Ontology (GO) - Molecular Function for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16713569
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSFX1: view

Phenotypes for HSFX1 Gene

GenomeRNAi human phenotypes for HSFX1:
genes like me logo Genes that share phenotypes with HSFX1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSFX1 Gene

Localization for HSFX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSFX1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for HSFX1 Gene COMPARTMENTS Subcellular localization image for HSFX1 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HSFX1: view

Pathways for HSFX1 Gene

SuperPathways for HSFX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSFX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSFX1: view

No data available for Pathways by source for HSFX1 Gene

Transcripts for HSFX1 Gene

mRNA/cDNA for HSFX1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSFX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSFX1 Gene

No ASD Table

Relevant External Links for HSFX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSFX1 Gene

mRNA expression in normal human tissues for HSFX1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSFX1 Gene

SOURCE GeneReport for Unigene cluster for HSFX1 Gene Hs.656936

mRNA Expression by UniProt/SwissProt for HSFX1 Gene

Tissue specificity: Testis-specific.
genes like me logo Genes that share expressions with HSFX1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSFX1 Gene

Orthologs for HSFX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSFX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
-- 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 19 (a)
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
-- 36
  • 35 (a)
-- 36
  • 32 (a)
(Mus musculus)
Mammalia Hsfy2 36
  • 23 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 20 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
-- 36
  • 35 (a)
(Gallus gallus)
Aves -- 36
  • 32 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
Species with no ortholog for HSFX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSFX1 Gene

Gene Tree for HSFX1 (if available)
Gene Tree for HSFX1 (if available)

Paralogs for HSFX1 Gene

Paralogs for HSFX1 Gene

Selected SIMAP similar genes for HSFX1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSFX1: view

Variants for HSFX1 Gene

Sequence variations from dbSNP and Humsavar for HSFX1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs372442 -- 149,772,240(+) TGCCA(C/G)AACGG upstream-variant-2KB
rs381508 -- 149,772,828(+) TTTAC(A/C)CGTGC upstream-variant-2KB
rs403539 -- 149,775,271(+) GGAGG(C/G)GTTAA intron-variant
rs420505 -- 149,776,915(+) ACCCC(C/G)CTCCG downstream-variant-500B
rs445433 -- 149,777,204(+) GGCGT(A/G)GTGGC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HSFX1 Gene

Variant ID Type Subtype PubMed ID
nsv525908 CNV Gain 19592680
nsv518742 CNV Gain 19592680
nsv508809 CNV Insertion 20534489
nsv818041 CNV Gain 17921354

Relevant External Links for HSFX1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSFX1 Gene

Disorders for HSFX1 Gene

No disorders were found for HSFX1 Gene.

No data available for UniProtKB/Swiss-Prot for HSFX1 Gene

Publications for HSFX1 Gene

  1. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (PMID: 15044259) Shinka T. … Nakahori Y. (Biol. Reprod. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. (PMID: 20388717) Blomster H.A. … Sistonen L. (J. Biol. Chem. 2010) 3 4
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PMID: 16713569) Lim J. … Zoghbi H.Y. (Cell 2006) 3

Products for HSFX1 Gene

Sources for HSFX1 Gene

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