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HSF5 Gene

protein-coding   GIFtS: 42
GCID: GC17M056497

Heat Shock Transcription Factor Family Member 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Transcription Factor Family Member 51 2
Heat Shock Transcription Factor 52 3
HSF 52 3
HSTF 52 3
Heat Shock Factor Protein 52
HSTF53

External Ids:    HGNC: 268621   Entrez Gene: 1245352   Ensembl: ENSG000001761607   UniProtKB: Q4G1123   

Export aliases for HSF5 gene to outside databases

Previous GC identifers: GC17M053853 GC17M051858


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSF5 Gene:
HSF5 (heat shock transcription factor family member 5) is a protein-coding gene. Diseases associated with HSF5 include prediabetes syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112
Function: May act as a transcriptional factor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSF5 gene promoter:
         FOXF2   RREB-1   CUTL1   Evi-1   GATA-2   S8   CP2   FOXO4   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HSF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q23.2

HSF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M056497:  view genomic region     (about GC identifiers)

Start:
56,497,528 bp from pter      End:
56,565,759 bp from pter
Size:
68,232 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112 (See protein sequence)
Recommended Name: Heat shock factor protein 5  
Size: 596 amino acids; 65278 Da
Secondary accessions: Q08EH7 Q8N7V2
Alternative splicing: 2 isoforms:  Q4G112-1   Q4G112-2   

Explore the universe of human proteins at neXtProt for HSF5: NX_Q4G112

Explore proteomics data for HSF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073908.1  
    ENSEMBL proteins: 
     ENSP00000313243  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027725 HSF_fam
     IPR027736 HSF5
     IPR011991 WHTH_DNA-bd_dom
     IPR000232 HSF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q4G112

    ProtoNet protein and cluster: Q4G112

    1 Blocks protein domain: IPB000232 Heat shock factor (HSF)-type DNA-binding domain

    UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112
    Similarity: Belongs to the HSF family


    HSF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSF5_HUMAN, Q4G112
    Function: May act as a transcriptional factor (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HSF5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSF5:
     Decreased number of cells in m 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSF5_HUMAN, Q4G112: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HSF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSF5
    Interactions:

        Search GeneGlobe Interaction Network for HSF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for HSF5 (ENSP000003132434) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUPL2ENSP000002587424STRING: ENSP00000258742
    PDCD11ENSP000003588124STRING: ENSP00000358812
    RAD52ENSP000003512844STRING: ENSP00000351284
    BCKDKENSP000002197944STRING: ENSP00000219794
    PDK1ENSP000002820774STRING: ENSP00000282077
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    HSF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSF5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSF5 gene: 
    NM_001080439.1  

    Unigene Cluster for HSF5:

    Heat shock transcription factor family member 5
    Hs.380061  [show with all ESTs]
    Unigene Representative Sequence: BC033020
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000323777(uc002iwi.1)
    miRNA
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    hsa-miR-3164 hsa-miR-429 hsa-miR-605 hsa-miR-342-3p hsa-miR-766 hsa-miR-4267 hsa-miR-124 hsa-miR-506
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      QuantiFast Probe-based Assays in human, mouse, rat HSF5

    Additional mRNA sequence: 

    AL137385.1 BC033017.1 BC033020.1 BC115385.1 BC115386.1 

    3 DOTS entries:

    DT.91649680  DT.40118936  DT.409641 

    Selected AceView cDNA sequences (see all 31):

    AA382290 BC033020 AA399313 AA383289 BX091293 BC033017 AL137385 T18969 
    AI916926 AA994657 BF057790 AA429653 AA994365 AL044302 BI832030 BG722338 
    BI461281 CD359981 CD244004 BF966627 AI208574 AI806241 BG723204 AA382291 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSF5 Expression
    About this image

    HSF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380061
        Custom PCR Arrays for HSF5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HSF5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf51 , 5 heat shock transcription factor family member 51, 5 88.78(n)1
    87.71(a)1
      11 (52.16 cM)5
    3279921  NM_001045527.11  NP_001038992.11 
     876171645 
    chicken
    (Gallus gallus)
    Aves LOC1008580641 heat shock factor protein 5-like 70.78(n)
    61.52(a)
      100858064  XM_003642383.2  XP_003642431.2 
    lizard
    (Anolis carolinensis)
    Reptilia HSF56
    heat shock transcription factor family member 5
    62(a)
    1 ↔ 1
    GL344014.1(94633-103865)
    zebrafish
    (Danio rerio)
    Actinopterygii CF348370.12   -- 81.69(n)    CF348370.1 


    ENSEMBL Gene Tree for HSF5 (if available)
    TreeFam Gene Tree for HSF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSF5 (see all 1166)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906475171,2
    C--56497240(+) TGAGAC/TAGATC 1 -- ds50010--------
    rs1442685841,2
    --56497362(+) CTAACA/GGCATT 1 -- ds50010--------
    rs1487199831,2
    --56497386(+) TGCTAC/TTCAAG 1 -- ds50010--------
    rs1829943631,2
    --56497738(+) GTAAGA/GATAGC 1 -- ut310--------
    rs1886917281,2
    --56497740(+) AAGGAG/TAGCAG 1 -- ut310--------
    rs1911929291,2
    --56497910(+) AAGCTA/GAGAAA 1 -- ut310--------
    rs1422973841,2
    --56497998(+) AAATTA/GGGTCT 1 -- ut310--------
    rs1478738701,2
    C--56498388(+) TTTCTA/GCAGTG 1 -- ut310--------
    rs1418937521,2
    --56498479(+) TCACTA/GGATAA 1 -- ut310--------
    rs1833975091,2
    --56498905(+) AAACTG/TTAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HSF5 (56497528 - 56565759 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSF5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666333CNV Deletion23128226
    nsv908641CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for HSF5:    About MalaCards
    prediabetes syndrome

    1 disease from the University of Copenhagen DISEASES database for HSF5:
    Prediabetes syndrome

    HSF5 for disorders           About GeneDecksing


    Export disorders for HSF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSF5 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HSF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124535 HGNC: 26862 AceView: FLJ40311 Ensembl:ENSG00000176160 euGenes: HUgn124535
    ECgene: HSF5 H-InvDB: HSF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSF5 gene:
    Search GeneIP for patents involving HSF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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