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Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 3 4 5
  • Heat Shock Transcription Factor Family Member 5 2
  • HSTF 5 4
  • HSTF5 4
  • HSF 5 4

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HSF5 Gene

  • May act as a transcriptional factor.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

Regulatory Elements for HSF5 Gene

Enhancers for HSF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G058389 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +97.3 97312 2.5 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 RNF43 TRIM37 ENSG00000264112 SUPT4H1 HSF5 SRSF1
GH17G058374 1.6 Ensembl ENCODE dbSUPER 11 +108.4 108445 10.4 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 TRIM37 RAD51C RNF43 SUPT4H1 HSF5 LPO EPX MSX2P1 OR4D1 MTMR4
GH17G058511 1.4 ENCODE dbSUPER 11.6 -27.8 -27816 8.9 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 TRIM37 RAD51C HSF5 VEZF1 SEPT4 C17orf47 SRSF1 SUPT4H1 RNF43 MTMR4
GH17G058362 1.5 Ensembl ENCODE dbSUPER 10.8 +123.5 123519 3.9 PKNOX1 ARNT ARID4B DMAP1 ZNF48 TCF12 ZNF766 GATA2 KLF13 SP5 TSPOAP1 RNF43 HSF5 SUPT4H1 TRIM37
GH17G058387 1.3 ENCODE dbSUPER 11 +100.2 100187 1.6 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 ZBTB7B ZNF766 ZNF207 FOS RNF43 SUPT4H1 SKA2 HSF5 PPM1E LPO DYNLL2 TRIM37
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSF5 Gene

Chromosome:
17
Start:
58,420,167 bp from pter
End:
58,488,401 bp from pter
Size:
68,235 bases
Orientation:
Minus strand

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G112-HSF5_HUMAN
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Q4G112
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    Size:
    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF5 Gene

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Suggested Antigen Peptide Sequences for HSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q4G112

UniProtKB/Swiss-Prot:

HSF5_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

No data available for Gene Families for HSF5 Gene

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSF5: view
genes like me logo Genes that share phenotypes with HSF5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HSF5: view

Pathways & Interactions for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Drugs & Compounds for HSF5 Gene

No Compound Related Data Available

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

Unigene Clusters for HSF5 Gene

Heat shock transcription factor family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSF5

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
HSF5
ECgene alternative splicing isoforms for
HSF5

Expression for HSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF5 Gene



Protein tissue co-expression partners for HSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF5 Gene:

HSF5

SOURCE GeneReport for Unigene cluster for HSF5 Gene:

Hs.380061
genes like me logo Genes that share expression patterns with HSF5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF5 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia HSF5 34 35
  • 91.32 (n)
cow
(Bos Taurus)
Mammalia HSF5 34 35
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Hsf5 34 16 35
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia Hsf5 34
  • 88.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF5 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF5 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858064 34
  • 70.78 (n)
HSF5 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF5 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hsf5 35
  • 32 (a)
OneToOne
Species where no ortholog for HSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

ENSEMBL:
Gene Tree for HSF5 (if available)
TreeFam:
Gene Tree for HSF5 (if available)

Paralogs for HSF5 Gene

No data available for Paralogs for HSF5 Gene

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000020417 -- 58,463,544(+) CAATA(A/C)TTCTT intron-variant
rs1000050063 -- 58,463,919(+) TTTGC(A/T)GAGAG intron-variant
rs1000073788 -- 58,459,921(+) GGATA(A/C)TTTAT intron-variant
rs1000077964 -- 58,467,643(+) AAATA(C/T)GGTGG intron-variant
rs1000129261 -- 58,452,671(+) TAGGC(A/G)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
esv2666333 CNV deletion 23128226
nsv575800 CNV gain 21841781
nsv960509 CNV duplication 23825009

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF5 Gene

Disorders for HSF5 Gene

Relevant External Links for HSF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF5

No disorders were found for HSF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D. … Blackwell J.M. (Genes Immun. 2014) 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for HSF5 Gene

Sources for HSF5 Gene

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