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Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor Family Member 5 2 3
  • Heat Shock Transcription Factor 5 4
  • HSTF 5 4
  • HSTF5 4
  • HSF 5 4

External Ids for HSF5 Gene

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor Family Member 5) is a Protein Coding gene. Diseases associated with HSF5 include prediabetes syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HSF5 Gene

  • May act as a transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

Genomic Location for HSF5 Gene

Start:
58,420,167 bp from pter
End:
58,488,398 bp from pter
Size:
68,232 bases
Orientation:
Minus strand

Genomic View for HSF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Regulatory Elements for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G112-HSF5_HUMAN
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Q4G112
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    Size:
    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF5 Gene

Proteomics data for HSF5 Gene at MOPED

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains for HSF5 Gene

Protein Domains for HSF5 Gene

UniProtKB/Swiss-Prot:

HSF5_HUMAN
Family:
  • Belongs to the HSF family.:
    • Q4G112
genes like me logo Genes that share domains with HSF5: view

No data available for Gene Families for HSF5 Gene

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function: May act as a transcriptional factor.

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSF5: view

Phenotypes for HSF5 Gene

genes like me logo Genes that share phenotypes with HSF5: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF5 Gene COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HSF5: view

Pathways for HSF5 Gene

SuperPathways for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source for HSF5 Gene

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

Unigene Clusters for HSF5 Gene

Heat shock transcription factor family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
HSF5
ECgene alternative splicing isoforms for
HSF5

Expression for HSF5 Gene

mRNA expression in normal human tissues for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (47.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSF5 Gene

SOURCE GeneReport for Unigene cluster for HSF5 Gene Hs.380061

genes like me logo Genes that share expressions with HSF5: view

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF5 36
  • 99.5 (n)
  • 99.16 (a)
HSF5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSF5 36
  • 89.19 (n)
  • 87.73 (a)
HSF5 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSF5 36
  • 91.32 (n)
  • 90.25 (a)
HSF5 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsf5 36
  • 88.78 (n)
  • 87.71 (a)
Hsf5 16
Hsf5 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSF5 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF5 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf5 36
  • 88.52 (n)
  • 87.14 (a)
chicken
(Gallus gallus)
Aves HSF5 37
  • 57 (a)
OneToOne
LOC100858064 36
  • 70.78 (n)
  • 61.52 (a)
lizard
(Anolis carolinensis)
Reptilia HSF5 37
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hsf5 37
  • 32 (a)
OneToOne
Species with no ortholog for HSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

ENSEMBL:
Gene Tree for HSF5 (if available)
TreeFam:
Gene Tree for HSF5 (if available)

Paralogs for HSF5 Gene

No data available for Paralogs for HSF5 Gene

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs717828 -- 58,458,571(+) TATTA(A/G)GAAAA intron-variant
rs917482 -- 58,463,219(+) TACTT(C/T)TGTCT missense, reference
rs1017089 - 58,466,919(+) AGGCA(G/T)TGGGA missense, reference
rs1468540 -- 58,484,581(+) CCAGA(C/T)ATGCA intron-variant
rs2333333 -- 58,486,191(-) agacg(A/G)ggttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
nsv908641 CNV Loss 21882294
esv2666333 CNV Deletion 23128226

Relevant External Links for HSF5 Gene

HapMap Linkage Disequilibrium report
HSF5

Disorders for HSF5 Gene

(1) MalaCards Diseases for HSF5 Gene

Search for HSF5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HSF5 Gene

genes like me logo Genes that share disorders with HSF5: view

No data available for UniProtKB/Swiss-Prot for HSF5 Gene

Publications for HSF5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for HSF5 Gene

Sources for HSF5 Gene

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