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Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 4
  • Heat Shock Transcription Factor Family Member 5 2 3 5
  • HSTF 5 4
  • HSTF5 4
  • HSF 5 4

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. Diseases associated with HSF5 include Prediabetes Syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HSF5 Gene

  • May act as a transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

Regulatory Elements for HSF5 Gene

Enhancers for HSF5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSF5 on UCSC Golden Path with GeneCards custom track

Promoters for HSF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSF5 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSF5 Gene

58,420,167 bp from pter
58,488,401 bp from pter
68,235 bases
Minus strand

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene


neXtProt entry for HSF5 Gene

Proteomics data for HSF5 Gene at MOPED

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Protein Domains for HSF5 Gene

Suggested Antigen Peptide Sequences for HSF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HSF family.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

No data available for Gene Families for HSF5 Gene

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.
genes like me logo Genes that share phenotypes with HSF5: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

Jensen Localization Image for HSF5 Gene COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for HSF5 Gene

Pathways & Interactions for HSF5 Gene

SuperPathways for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene


No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Drugs & Compounds for HSF5 Gene

No Compound Related Data Available

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

Unigene Clusters for HSF5 Gene

Heat shock transcription factor family member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSF5 Gene

mRNA expression in normal human tissues for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF5 Gene

SOURCE GeneReport for Unigene cluster for HSF5 Gene Hs.380061

genes like me logo Genes that share expression patterns with HSF5: view

Protein tissue co-expression partners for HSF5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSF5 35
  • 89.19 (n)
  • 87.73 (a)
HSF5 36
  • 84 (a)
(Canis familiaris)
Mammalia HSF5 35
  • 91.32 (n)
  • 90.25 (a)
HSF5 36
  • 87 (a)
(Mus musculus)
Mammalia Hsf5 35
  • 88.78 (n)
  • 87.71 (a)
Hsf5 16
Hsf5 36
  • 86 (a)
(Pan troglodytes)
Mammalia HSF5 35
  • 99.5 (n)
  • 99.16 (a)
HSF5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hsf5 35
  • 88.52 (n)
  • 87.14 (a)
(Monodelphis domestica)
Mammalia HSF5 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia HSF5 36
  • 69 (a)
(Gallus gallus)
Aves LOC100858064 35
  • 70.78 (n)
  • 61.52 (a)
HSF5 36
  • 57 (a)
(Anolis carolinensis)
Reptilia HSF5 36
  • 62 (a)
(Danio rerio)
Actinopterygii hsf5 36
  • 32 (a)
Species with no ortholog for HSF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

Gene Tree for HSF5 (if available)
Gene Tree for HSF5 (if available)

Paralogs for HSF5 Gene

No data available for Paralogs for HSF5 Gene

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1017089 - 58,466,919(+) AGGCA(A/G/T)TGGGA reference, missense
rs3803752 - 58,462,906(-) AAATA(A/G)CACAA reference, missense
rs717828 -- 58,458,571(+) TATTA(A/G)GAAAA intron-variant
rs917482 -- 58,463,219(+) TACTT(C/T)TGTCT reference, missense
rs1468540 -- 58,484,581(+) CCAGA(C/T)ATGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
nsv908641 CNV Loss 21882294
esv2666333 CNV Deletion 23128226

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSF5 Gene

Disorders for HSF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
prediabetes syndrome
  • prediabetes
- elite association - COSMIC cancer census association via MalaCards
Search HSF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 67
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D. … Blackwell J.M. (Genes Immun. 2014) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HSF5 Gene

Sources for HSF5 Gene