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Aliases for HSF5 Gene

Aliases for HSF5 Gene

  • Heat Shock Transcription Factor 5 2 3 4 5
  • Heat Shock Transcription Factor Family Member 5 2
  • HSTF 5 4
  • HSTF5 4
  • HSF 5 4

External Ids for HSF5 Gene

Previous GeneCards Identifiers for HSF5 Gene

  • GC17M053853
  • GC17M056497
  • GC17M051858

Summaries for HSF5 Gene

GeneCards Summary for HSF5 Gene

HSF5 (Heat Shock Transcription Factor 5) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HSF5 Gene

  • May act as a transcriptional factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF5 Gene

Genomics for HSF5 Gene

Regulatory Elements for HSF5 Gene

Enhancers for HSF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F058510 0.6 FANTOM5 11.7 -21.9 -21931 0.1 HDGF ZFHX2 BHLHE40 GLI4 ZNF785 EGR2 SEPT4 HSF5 C17orf47 SUPT4H1 MTMR4 DYNLL2 PPM1E MKS1 PIR59993
GH17F058511 0.2 ENCODE 11.6 -27.8 -27816 8.9 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 TRIM37 RAD51C SRSF1 SETP3 OR4D1 ENSG00000264914 SPDYE22P LOC101927557 HSF5 VEZF1
GH17F058409 0.2 Ensembl 11.1 +79.3 79301 0.2 SUPT4H1 HSF5 TSPOAP1 LPO MTMR4 RNF43
GH17F058400 0.9 Ensembl ENCODE 11.1 +85.6 85635 3.8 HDAC1 PKNOX1 ZNF133 INSM2 RAD21 ELK1 SCRT2 RCOR1 ZNF654 CEBPB TRIM37 RAD51C SUPT4H1 HSF5 TSPOAP1 LPO MTMR4 RNF43
GH17F058390 0.2 Ensembl 11 +99.3 99301 0.2 SIX4 KLF6 ZHX2 DPF2 RAD21 ZNF843 OSR2 GATA3 ZNF366 GATA2 RNF43 SUPT4H1 HSF5 LPO
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSF5 on UCSC Golden Path with GeneCards custom track

Promoters for HSF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001808448 501 601 CTCF ZNF157 POLR2A MAX

Genomic Location for HSF5 Gene

Chromosome:
17
Start:
58,420,167 bp from pter
End:
58,488,401 bp from pter
Size:
68,235 bases
Orientation:
Minus strand

Genomic View for HSF5 Gene

Genes around HSF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF5 Gene

Proteins for HSF5 Gene

  • Protein details for HSF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4G112-HSF5_HUMAN
    Recommended name:
    Heat shock factor protein 5
    Protein Accession:
    Q4G112
    Secondary Accessions:
    • Q08EH7
    • Q8N7V2

    Protein attributes for HSF5 Gene

    Size:
    596 amino acids
    Molecular mass:
    65278 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF5 Gene

Post-translational modifications for HSF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF5 Gene

Domains & Families for HSF5 Gene

Suggested Antigen Peptide Sequences for HSF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q4G112

UniProtKB/Swiss-Prot:

HSF5_HUMAN :
  • Belongs to the HSF family.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF5: view

No data available for Gene Families for HSF5 Gene

Function for HSF5 Gene

Molecular function for HSF5 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional factor.

Gene Ontology (GO) - Molecular Function for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSF5: view
genes like me logo Genes that share phenotypes with HSF5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSF5 Gene

Localization for HSF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF5 Gene COMPARTMENTS Subcellular localization image for HSF5 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HSF5: view

Pathways & Interactions for HSF5 Gene

SuperPathways for HSF5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSF5: view

No data available for Pathways by source and SIGNOR curated interactions for HSF5 Gene

Transcripts for HSF5 Gene

mRNA/cDNA for HSF5 Gene

Unigene Clusters for HSF5 Gene

Heat shock transcription factor family member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF5 Gene

No ASD Table

Relevant External Links for HSF5 Gene

GeneLoc Exon Structure for
HSF5
ECgene alternative splicing isoforms for
HSF5

Expression for HSF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSF5 Gene

mRNA differential expression in normal tissues according to GTEx for HSF5 Gene

This gene is overexpressed in Testis (x47.9).

Protein differential expression in normal tissues from HIPED for HSF5 Gene

This gene is overexpressed in Testis (53.4) and Synovial fluid (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSF5 Gene



Protein tissue co-expression partners for HSF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF5 Gene:

HSF5

SOURCE GeneReport for Unigene cluster for HSF5 Gene:

Hs.380061
genes like me logo Genes that share expression patterns with HSF5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HSF5 Gene

Orthologs for HSF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF5 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia HSF5 34 35
  • 91.32 (n)
cow
(Bos Taurus)
Mammalia HSF5 34 35
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Hsf5 34 16 35
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia Hsf5 34
  • 88.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF5 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF5 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858064 34
  • 70.78 (n)
HSF5 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF5 35
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hsf5 35
  • 32 (a)
OneToOne
Species where no ortholog for HSF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF5 Gene

ENSEMBL:
Gene Tree for HSF5 (if available)
TreeFam:
Gene Tree for HSF5 (if available)

Paralogs for HSF5 Gene

No data available for Paralogs for HSF5 Gene

Variants for HSF5 Gene

Sequence variations from dbSNP and Humsavar for HSF5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1017089 -- 58,466,919(+) AGGCA(G/T)TGGGA reference, missense
rs10611975 -- 58,480,403(+) AAAAA(-/CAA)GTTCA intron-variant
rs11079351 -- 58,460,510(+) acaca(C/T)atact intron-variant
rs111392167 -- 58,472,432(+) ATCAT(G/T)CCACT intron-variant
rs111455302 -- 58,477,115(+) TATAT(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF5 Gene

Variant ID Type Subtype PubMed ID
esv2666333 CNV deletion 23128226
nsv575800 CNV gain 21841781
nsv960509 CNV duplication 23825009

Variation tolerance for HSF5 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.05; 80.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF5 Gene

Disorders for HSF5 Gene

Relevant External Links for HSF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF5

No disorders were found for HSF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSF5 Gene

Publications for HSF5 Gene

  1. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64
  2. Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study. (PMID: 25208829) Anderson D. … Blackwell J.M. (Genes Immun. 2014) 3 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for HSF5 Gene

Sources for HSF5 Gene

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