HSF5 Gene
protein-coding GIFtS: 40
GCID: GC17M056497
|
|
heat shock transcription factor family member 5
| |
Aliases
for HSF5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heat Shock Transcription Factor Family Member 51 2 | | FLJ403111 | | Heat Shock Transcription Factor 52 3 | | Heat Shock Factor Protein 52 | | HSF 52 3 | | HSTF53 | | HSTF 52 3 | | |
Export aliases for HSF5 gene to outside databasesPrevious GC identifers: GC17M053853 GC17M051858 |
Summaries
for HSF5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112Function: May act as a transcriptional factor (By similarity)
|
Genomic Views
for HSF5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSF5 gene promoter:
FOXF2 RREB-1 CUTL1 Evi-1 GATA-2 S8 CP2 FOXO4 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSF5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q22 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q23.2HSF5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M056497: view genomic region
(about GC identifiers)
Start:
|
56,497,528 bp from pter |
End:
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56,565,759 bp from pter |
Size:
|
68,232 bases |
Orientation:
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minus strand |
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Proteins
for HSF5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112 (See
protein sequence)Recommended Name: Heat shock factor protein 5 Size: 596 amino acids; 65278 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q08EH7 Q8N7V2Alternative splicing: 2 isoforms: Q4G112-1 Q4G112-2 Explore the universe of human proteins at neXtProt for HSF5: NX_Q4G112
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q4G112
HSF5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073908.1
ENSEMBL proteins: ENSP00000313243
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
HSF5 for ontologies About GeneDecksing
HSF5 Antibody Products:
Assay Products for HSF5: |
Protein
Domains /
Families
for HSF5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSF5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q4G112ProtoNet protein and cluster: Q4G112 1 Blocks protein family: IPB000232 Heat shock factor (HSF)-type DNA-binding domain
UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112Similarity: Belongs to the HSF family |
Function
for HSF5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HSF5_HUMAN, Q4G112Function: May act as a transcriptional factor (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: HSF5 (NM_001080439) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSF5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
HSF5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HSF5:
|
Pathways & Interactions
for HSF5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSF5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
HSF5 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSF5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HSF5
Search CenterWatch for drugs/clinical trials and news about HSF5
|
Transcripts
for HSF5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSF5 gene: NM_001080439.1 Unigene Cluster for HSF5: Heat shock transcription factor family member 5 Hs.380061 [show with all ESTs]Unigene Representative Sequence: BC0330201 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000323777(uc002iwi.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HSF5 (NM_001080439) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSF5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF5 |
Additional cDNA sequence: AL137385.1 BC033017.1 BC033020.1 BC115385.1 BC115386.1 3 DOTS entries: DT.91649680 DT.40118936 DT.409641 24/31 AceView cDNA sequences (see all 31): AL137385 AA399313 T18969 AI916926 BX091293 BC033017 BC033020 AA383289 AA382290 BF057790 CD359981 AA994657 AL044302 BG722338 AA429653 CD244004 AA994365 BI461281 BI832030 BG723204 AI806241 AI208574 BF966627 AA382291
GeneLoc Exon Structure
|
Expression
for HSF5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HSF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSF5
SOURCE GeneReport for Unigene cluster: Hs.380061
SABiosciences Custom PCR Arrays for HSF5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSF5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF5 |
Orthologs
for HSF5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HSF5 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC1008580641 |
heat shock factor protein 5-like |
71.46(n)
61.81(a) |
|
100858064 XM_003642383.1 XP_003642431.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HSF56 |
-- |
57(a) |
1 ↔ 1 |
GL344014.1(94633-103865) |
zebrafish
(Danio rerio) |
Actinopterygii |
CF348370.12 |
-- |
81.69(n) |
|
CF348370.1 |
ENSEMBL Gene Tree for HSF5 (if available)
TreeFam Gene Tree for HSF5 (if available) |
Paralogs
for HSF5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HSF5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSF5 (56497528 - 56565759 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSF5
1 CNV: 4410 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSF5 |
|
Disorders
/ Diseases
for HSF5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSF5 for disorders About GeneDecksing
1  disease for HSF5: About MalaCardsprediabetes syndrome
1 disease from the University of Copenhagen DISEASES database for HSF5:Prediabetes syndrome Export disorders for HSF5 gene to outside databases
|
Publications
for HSF5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSF5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HSF5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HSF5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HSF5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSF5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSF5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HSF5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSF5 gene:
Search GeneIP for patents involving HSF5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSF5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HSF5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSF5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSF5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSF5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSF5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF5 |
| |
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| | | | Search Tocris compounds for HSF5 |
| |  |  |  |  | | | | |
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 |
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 | | | HSF5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF5 |
|  |  |  | | | | Search ThermoFisher Antibodies for HSF5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF5 |
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