Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSF4 Gene

protein-coding   GIFtS: 61
GCID: GC16P067197

heat shock transcription factor 4

(Previous names: cataract, Marner )
(Previous symbol: CTM)
 Explore 25 diseases affiliated with
HSF4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSF4    

Aliases
for HSF4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Heat Shock Transcription Factor 41 2 3     HSTF 42 3
CTM1 2 5     Cataract, Marner1
HHSF41     Heat Shock Factor Protein 42
HSF 42 3     

External Ids:    HGNC: 52271   Entrez Gene: 32992   Ensembl: ENSG000001028787   OMIM: 6024385   UniProtKB: Q9ULV53   
ORGUL members:         
NONCODE:n339251    

Export aliases for HSF4 gene to outside databases

Previous GC identifers: GC16P057891 GC16P067576 GC16P066932 GC16P066974 GC16P065756 GC16P053070


Summaries
for HSF4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSF4:
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses.
HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested
to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding
distinct isoforms and possessing different transcriptional activity have been described. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses
transcription while the isoform HSF4B activates transcription

Gene Wiki entry for HSF4


Genomic Views
for HSF4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSF4 gene promoter:
         E2F-1   E2F   p53   ATF-2   c-Jun   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q21

HSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067197:  view genomic region     (about GC identifiers)

Start:
 67,197,288 bp from pter      End:
 67,203,848 bp from pter
Size:
 6,561 bases      Orientation:
 plus strand

Proteins
for HSF4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5 (See protein sequence)
Recommended Name: Heat shock factor protein 4  
Size: 492 amino acids; 53011 Da
Subunit: Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with
DUSP26, MAPK1, MAPK2 and MAP kinase p38
Subcellular location: Nucleus
Secondary accessions: Q99472 Q9ULV6
Alternative splicing: 2 isoforms:  Q9ULV5-1   Q9ULV5-2   

Explore the universe of human proteins at neXtProt for HSF4: NX_Q9ULV5

Post-translational modifications:

  • Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-2931
  • Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by
    • phosphorylation on Ser-298. HSFA is not sumoylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9ULV5

    • HSF4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035757.1  NP_001529.2  

    ENSEMBL proteins: 
     ENSP00000427832   ENSP00000403219   ENSP00000429580   ENSP00000428161   ENSP00000430631  
     ENSP00000428978   ENSP00000430947   ENSP00000463706   ENSP00000430299   ENSP00000430724  
     ENSP00000430211   ENSP00000428077   ENSP00000427963   ENSP00000430840   ENSP00000429486  
     ENSP00000264009   ENSP00000408815  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HSF4
    OriGene Custom Protein Services for HSF4 
    GenScript Custom Purified and Recombinant Proteins Services for HSF4
    Novus Biologicals HSF4 Protein
    Novus Biologicals HSF4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HSF4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    HSF4 for ontologies           About GeneDecksing



    HSF4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HSF4
    OriGene Antibodies: HSF4
    OriGene Custom Antibody Services for HSF4 
    GenScript Custom Superior Antibodies Services for HSF4
    Novus Biologicals HSF4 Antibodies
    Abcam antibodies for HSF4 
    Uscn Antibodies for HSF4
    Search ThermoFisher Antibodies for HSF4

    Assay Products for HSF4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSF4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HSF4

    Protein Domains /
    Families
    for HSF4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSF4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR000232 HSF_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q9ULV5

    ProtoNet protein and cluster: Q9ULV5

    1 Blocks protein family: IPB000232 Heat shock factor (HSF)-type DNA-binding domain

    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
    Similarity: Belongs to the HSF family


    Function
    for HSF4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
    Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses
    transcription while the isoform HSF4B activates transcription

         Genatlas biochemistry entry for HSF4:
    heat shock transcription factor 4,preferentially expressed in heart,brain,skeletal muscle,pancreas,potential repressor
    of genes for HS proteins and molecular chaperones with two alternatively spliced isoform HSF4a,HSF4b,the former acting
    as an inhibitor,the latter as an activator of tissue specific heat shock gene expression

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HSF4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSF4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HSF4
    SwitchGear 3'UTR luciferase reporter plasmid: HSF4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF4 (see all 7)
    OriGene shRNA RFP: HSF4
    OriGene siRNA: HSF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSF4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HSF4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSF4 (NM_001040667)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HSF4
    Search LifeMap BioReagents cell lines for HSF4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8972228
    GO:0043565sequence-specific DNA binding IEA--


    HSF4 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for HSF4:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

    Animal Models:
         Mouse knock-outs for HSF4: Hsf4tm1Xyk Hsf4tm1Anak
         1 MGI mutant phenotype (inferred from 4 alleles) (MGI details for Hsf4):
     vision/eye 

    HSF4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HSF4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/12 Interacting proteins for HSF4 (Q9ULV52, 3 ENSP000002640094) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2AP2O759562, 3MINT-8251208 I2D: score=2 
    NUDT21O438092, 3MINT-8264369 I2D: score=2 
    C5orf54Q8IZ132, 3, ENSP000003861844MINT-8259318 I2D: score=2 STRING: ENSP00000386184
    MAPK1P284823, ENSP000002158324I2D: score=3 STRING: ENSP00000215832
    DUSP26Q9BV473, ENSP000002562614I2D: score=2 STRING: ENSP00000256261
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001654eye development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent TAS8972228
    GO:0006950response to stress IEA--


    HSF4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSF4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSF4
    Search CenterWatch for drugs/clinical trials and news about HSF4 

    Transcripts
    for HSF4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSF4 gene (2 alternative transcripts): 
    NM_001040667.2  NM_001538.3  

    Unigene Cluster for HSF4:

    Heat shock transcription factor 4
    Hs.512156  [show with all ESTs]
    Unigene Representative Sequence: NM_001040667
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000518227 ENST00000518603 ENST00000522870 ENST00000522295 ENST00000434833
    ENST00000522023 ENST00000521314 ENST00000521624 ENST00000523562 ENST00000517685
    ENST00000521374 ENST00000584272 ENST00000523077 ENST00000517729 ENST00000519224
    ENST00000517750 ENST00000517680 ENST00000522027

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): HSF4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSF4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HSF4
    SwitchGear 3'UTR luciferase reporter plasmid: HSF4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF4 (see all 7)
    OriGene shRNA RFP: HSF4
    OriGene siRNA: HSF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSF4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HSF4 (NM_001040667)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSF4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF4

    Additional cDNA sequence: 

    AB029348.1 AK225152.1 AK293631.1 AK296210.1 AK307211.1 AK308638.1 BC130383.1 D87673.1 

    13 DOTS entries:

    DT.100776610  DT.86852810  DT.95162422  DT.100776611  DT.95340077  DT.75102472  DT.95126720  DT.92021386 
    DT.91715687  DT.75102473  DT.95162423  DT.70105481  DT.95072645 

    24/76 AceView cDNA sequences (see all 76):

    BQ771634 CR598009 CA412687 BM710035 AI695801 AW269998 AI632815 BX379491 
    AW510427 NM_018378 BF435646 BU783076 BQ014576 AI564638 BQ673948 AI765859 
    BX102546 CR611910 AI684125 BM768246 AW295973 BI906561 BC014414 BG164451 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HSF4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:                          -                       -     -                                               -                     
    SP2:                          -                       -                 -                                   -                     
    SP3:                                                                                            -     -     -                     
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for HSF4

    Expression
    for HSF4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCTGTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HSF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSF4

    SOURCE GeneReport for Unigene cluster: Hs.512156

    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
    Tissue specificity: Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues

        SABiosciences Expression via Pathway-Focused PCR Array including HSF4: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSF4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF4

    Orthologs
    for HSF4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSF4 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HSF41 heat shock transcription factor 4 59.41(n)
    51.57(a)    		   427540  NM_001172374.1  NP_001165845.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HSF46
    		 --
    		 51(a)
    		 1 ↔ 1
    		 5(108449730-108465268)
    zebrafish
    (Danio rerio)    		 Actinopterygii hsf41 heat shock transcription factor 4 63.78(n)
    56.77(a)    		   503739  NM_001013317.1  NP_001013335.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Hsf3 response to heat DNA binding 47(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y53C10A.123 HSF-type DNA-binding domain 40(a)   I(11961851-11970016)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT-HSFA96
    AT-HSFB2A6
    (see all 21)    		 heat stress transcription factor B-2a
    (see all 21)    		 8(a)
    21(a)
    (see all 21)    		 many ↔ many
    many ↔ many
    (see all 21)    		 5(21943983-21945651)
    5(24916089-24917643)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 25)    		 HSF-type DNA-binding domain containing protein, ex...
    CPuORF39 - conserved peptide uORF-containing trans...
    (see all 25)    		 27(a)
    23(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 1(30581441-30582699)
    9(17220425-17227960)


    ENSEMBL Gene Tree for HSF4 (if available)
    TreeFam Gene Tree for HSF4 (if available) 

    Paralogs
    for HSF4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSF4 gene
    HSF12  HSF22  
    2 SIMAP similar genes for HSF4 using alignment to 13 protein entries:     HSF4_HUMAN (see all proteins):
    HSF2    HSF1

    HSF4 for paralogs           About GeneDecksing



    Genomic Variants
    for HSF4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/98 NCBI SNPs in HSF4 are shown (see all 98)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs799110441,2
    		C--67195354(+) AAAAAG/AAAAAA 4 -- us2k1 int11Minor allele frequency- A:0.50WA 2
    rs1827281561,2
    		--67195358(+) AGAAAA/GAAAAA 4 -- us2k1 int10--------
    rs1878022521,2
    		--67195387(+) GTTCTC/GAACGT 4 -- us2k1 int10--------
    rs133127201,2
    		C,F,H,--67195452(-) CTCTCC/TGGAAA 4 -- us2k1 int119Minor allele frequency- T:0.10NS EA NA WA 2156
    rs1466877791,2
    		--67195517(+) ATCTGA/TTGCCC 4 -- us2k1 int10--------
    rs2010619791,2
    		C,--67195639(+) CCAGGC/TCGGAG 4 -- us2k1 ut510--------
    rs1927586501,2
    		C,--67195659(+) GTGGCG/TGATCC 4 -- ut51 us2k10--------
    rs1175751361,2
    		C,F,--67195842(+) TCAGGT/CGAGCC 3 -- us2k1 spd13Minor allele frequency- C:0.00EA NA EU 4891
    rs1833497581,2
    		--67195949(+) AATTGA/CTGGCC 3 -- us2k1 int10--------
    rs1878266841,2
    		--67196093(+) CGGGCA/CTGGTG 3 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for HSF4 (67197288 - 67203848 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSF4: --
    Human Gene Mutation Database (HGMD): HSF4

    Locus Specific Mutation Databases (LSDB): HSF4

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSF4
    DNA2.0 Custom Variant and Variant Library Synthesis for HSF4

    Disorders / Diseases
    for HSF4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSF4 for disorders           About GeneDecksing

    OMIM gene information: 602438   
    OMIM disorders: 116800  
    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
  • Defects in HSF4 are the cause of cataract, zonular (CZ) [MIM:116800]. A form of zonular cataract. Zonular or
    • lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain
    layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render
    the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded.
    Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus.
    Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as
    riders or spokes
  • Defects in HSF4 are the cause of cataract Marner type (CAM) [MIM:116800]. A form of cataract with variable and
    • progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar,
    or stellate cataract. Finger malformation is observed in some kindreds

    20/25 diseases for HSF4 (see all 25):    About MalaCards
    cataract    cataract, marner type    spinal stenosis    chronic purulent otitis media
    cauda equina neoplasm    spinal cord disease    otitis media    cataract, zonular
    cervical adenitis    acute tympanitis    intracranial hypotension    scheuermann's disease
    meningocele    ritter's disease    parotitis    lymphadenitis
    impetigo    radiculopathy    congenital cataracts    bronchitis

    13 diseases from the University of Copenhagen DISEASES database for HSF4:
    Acute tympanitis     Chronic purulent otitis media     Tonsillitis     Intracranial hypotension
    Bronchitis     Pneumonia     Meningocele     Radiculopathy
    Parotitis     Spinal cord disease     Pharyngitis     Cauda equina neoplasm
    Lymphadenitis

    2 Novoseek disease relationships for HSF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 58.9 31 19224648 (5), 16876512 (4), 15277496 (2), 19874706 (1)
    shock 57.4 15 15308659 (2), 8972228 (2), 17483205 (1), 11585899 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: HSF4 (3 documents)

    Export disorders for HSF4 gene to outside databases

    Publications
    for HSF4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSF4 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HSF4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. (PubMed id 8972228)1, 2, 3, 9 Nakai A.... Nagata K. (1997)
    2. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. (PubMed id 10488131)1, 2, 3, 9 Tanabe M....Nakai A. (1999)
    3. Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. (PubMed id 12089525)1, 2, 3 Bu L.... Kong X. (2002)
    4. Novel HSF4 mutation causes congenital total white cataract in a Chinese family. (PubMed id 16876512)1, 2, 9 Ke T....Liu M. (2006)
    5. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)1, 2 Hu Y. and Mivechi N.F. (2006)
    6. A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract. (PubMed id 15277496)1, 9 Smaoui N....Hejtmancik J.F. (2004)
    7. Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. (PubMed id 15308659)1, 9 Somasundaram T. and Bhat S.P. (2004)
    8. Heat shock factor 4a (HSF4a) represses HSF2 expressio n and HSF2-mediated transcriptional activity. (PubMed id 21792930)1 Kim S.A....Ahn S.G. (2012)
    9. HSF4 is involved in DNA damage repair through regulati on of Rad51. (PubMed id 22587838)1 Cui X....Liu M. (2012)
    10. Absence of mutations in four genes encoding for congen ital cataract and expressed in the human brain in Tunisian families with catarac t and mental retardation. (PubMed id 22103961)1 Chograni M....Chaabouni H.B. (2011)

    External Searches for HSF4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSF4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3299 HGNC: 5227 AceView: HSF4andFBXL8 Ensembl:ENSG00000102878 euGenes: HUgn3299
    ECgene: HSF4 H-InvDB: HSF4

    Other Databases showing HSF4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSF4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSF4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSF4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSF4 gene:
    Search GeneIP for patents involving HSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HSF4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for HSF4 (HSF4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HSF4   OriGene shRNA RFP for HSF4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF4  
     OriGene Protein Over-expression Lysate for HSF4   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HSF4   OriGene 3'-UTR Clone for HSF4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSF4   OriGene Custom Protein Services for HSF4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSF4
     Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSF4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSF4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF4
     GenScript Custom Purified and Recombinant Proteins Services for HSF4 GenScript cDNA clones with any tag delivered in your preferred vector for HSF4
     GenScript Custom Assay Services for HSF4 GenScript Custom Superior Antibodies Services for HSF4
     GenScript Custom overexpressing Cell Line Services for HSF4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSF4 promoter
     Search Chromatin IP Primers for HSF4
     RT2 qPCR Primer Assay in human, mouse, rat HSF4
     GNC Network for HSF4
     SABiosciences PCR Arrays including human, mouse, rat HSF4
     Search Tocris compounds for HSF4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSF4 antibodies
     HSF4 proteins
     HSF4 lysates
     Antibodies for HSF4
     See all of Abcam's Antibodies, Kits and Proteins for HSF4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HSF4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HSF4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF4
     SwitchGear 3'UTR luciferase reporter plasmids for HSF4
     SwitchGear Promoter luciferase reporter plasmids for HSF4
     Search ThermoFisher Antibodies for HSF4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF4
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HSF4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4