Aliases for HSF4 Gene
External Ids for HSF4 Gene
Previous HGNC Symbols for HSF4 Gene
Previous GeneCards Identifiers for HSF4 Gene
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSF4 Gene
HSF4 (Heat Shock Transcription Factor 4) is a Protein Coding gene. Diseases associated with HSF4 include cataract 5, multiple types and total early-onset cataract. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is HSF1.
UniProtKB/Swiss-Prot for HSF4 Gene
DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.