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Aliases for HSF4 Gene

Aliases for HSF4 Gene

  • Heat Shock Transcription Factor 4 2 3 4
  • HSTF 4 3 4
  • CTRCT5 3 6
  • HSF 4 3 4
  • HHSF4 3 4
  • CTM 3 6
  • Heat Shock Factor Protein 4 3
  • Cataract, Marner 2

External Ids for HSF4 Gene

Previous HGNC Symbols for HSF4 Gene

  • CTM

Previous GeneCards Identifiers for HSF4 Gene

  • GC16P057891
  • GC16P067576
  • GC16P066932
  • GC16P066974
  • GC16P065756
  • GC16P053070

Summaries for HSF4 Gene

Entrez Gene Summary for HSF4 Gene

  • Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSF4 Gene

HSF4 (Heat Shock Transcription Factor 4) is a Protein Coding gene. Diseases associated with HSF4 include cataract 5, multiple types and acute tympanitis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is HSF2.

UniProtKB/Swiss-Prot for HSF4 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.

Gene Wiki entry for HSF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF4 Gene

Genomics for HSF4 Gene

Regulatory Elements for HSF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSF4 Gene

67,163,385 bp from pter
67,169,945 bp from pter
6,561 bases
Plus strand

Genomic View for HSF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF4 Gene

Proteins for HSF4 Gene

  • Protein details for HSF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor protein 4
    Protein Accession:
    Secondary Accessions:
    • Q99472
    • Q9ULV6

    Protein attributes for HSF4 Gene

    492 amino acids
    Molecular mass:
    53011 Da
    Quaternary structure:
    • Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with ALKBH4, DUSP26, MAPK1, MAPK2 and MAP kinase p38.

    Alternative splice isoforms for HSF4 Gene


neXtProt entry for HSF4 Gene

Proteomics data for HSF4 Gene at MOPED

Post-translational modifications for HSF4 Gene

  • Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated.
  • Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for HSF4 Gene

Domains for HSF4 Gene

Protein Domains for HSF4 Gene

Suggested Antigen Peptide Sequences for HSF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9ULV5
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF4: view

No data available for Gene Families for HSF4 Gene

Function for HSF4 Gene

Molecular function for HSF4 Gene

GENATLAS Biochemistry: heat shock transcription factor 4,preferentially expressed in heart,brain,skeletal muscle,pancreas,potential repressor of genes for HS proteins and molecular chaperones with two alternatively spliced isoform HSF4a,HSF4b,the former acting as an inhibitor,the latter as an activator of tissue specific heat shock gene expression
UniProtKB/Swiss-Prot Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.

Gene Ontology (GO) - Molecular Function for HSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003714 transcription corepressor activity TAS 8972228
GO:0019903 protein phosphatase binding IPI 16581800
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HSF4: view
genes like me logo Genes that share phenotypes with HSF4: view

Animal Models for HSF4 Gene

MGI Knock Outs for HSF4:

Animal Model Products

CRISPR Products

miRNA for HSF4 Gene

miRTarBase miRNAs that target HSF4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSF4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HSF4 Gene

Localization for HSF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF4 Gene

Subcellular locations from

Jensen Localization Image for HSF4 Gene COMPARTMENTS Subcellular localization image for HSF4 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with HSF4: view

Pathways for HSF4 Gene

SuperPathways for HSF4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HSF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001654 eye development --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 8972228
GO:0006357 regulation of transcription from RNA polymerase II promoter --
genes like me logo Genes that share ontologies with HSF4: view

No data available for Pathways by source for HSF4 Gene

Transcripts for HSF4 Gene

Unigene Clusters for HSF4 Gene

Heat shock transcription factor 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSF4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c
SP1: - - - -
SP2: - - - -
SP3: - - -
SP7: -

Relevant External Links for HSF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSF4 Gene

mRNA expression in normal human tissues for HSF4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSF4 Gene

SOURCE GeneReport for Unigene cluster for HSF4 Gene Hs.512156

mRNA Expression by UniProt/SwissProt for HSF4 Gene

Tissue specificity: Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
genes like me logo Genes that share expressions with HSF4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSF4 Gene

Orthologs for HSF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSF4 35
  • 99.46 (n)
  • 99.39 (a)
HSF4 36
  • 99 (a)
(Bos Taurus)
Mammalia HSF4 35
  • 89.71 (n)
  • 92.84 (a)
HSF4 36
  • 93 (a)
(Canis familiaris)
Mammalia HSF4 35
  • 91.45 (n)
  • 92.67 (a)
HSF4 36
  • 92 (a)
(Mus musculus)
Mammalia Hsf4 35
  • 86.19 (n)
  • 86.94 (a)
Hsf4 16
Hsf4 36
  • 87 (a)
(Monodelphis domestica)
Mammalia HSF4 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 49 (a)
-- 36
  • 27 (a)
(Gallus gallus)
Aves HSF4 36
  • 44 (a)
(Anolis carolinensis)
Reptilia HSF4 36
  • 55 (a)
(Danio rerio)
Actinopterygii hsf4 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hsf 36
  • 19 (a)
Hsf 37
  • 47 (a)
(Caenorhabditis elegans)
Secernentea hsf-1 36
  • 18 (a)
Y53C10A.12 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 36
  • 12 (a)
HSF1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for HSF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HSF4 Gene

Gene Tree for HSF4 (if available)
Gene Tree for HSF4 (if available)

Paralogs for HSF4 Gene

Paralogs for HSF4 Gene

genes like me logo Genes that share paralogs with HSF4: view

Variants for HSF4 Gene

Sequence variations from dbSNP and Humsavar for HSF4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2272420 -- 67,164,687(-) CGGGG(A/G)CCACG utr-variant-5-prime
rs28937573 Pathogenic, Cataract 5, multiple types (CTRCT5) 67,165,841(+) TGCGG(C/T)GCAAG reference, missense
rs34623497 -- 67,164,901(+) GGGGA(C/T)CCAGG reference, synonymous-codon
rs34657618 -- 67,167,957(+) CAGAG(-/C)CCCCA intron-variant
rs35824613 -- 67,166,662(+) CCAAG(-/T)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF4 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv906794 CNV Loss 21882294
dgv2886n71 CNV Loss 21882294
dgv2887n71 CNV Loss 21882294
dgv2888n71 CNV Loss 21882294
nsv524363 CNV Loss 19592680
nsv827707 CNV Loss 20364138
nsv906803 CNV Loss 21882294
nsv522852 CNV Gain 19592680

Relevant External Links for HSF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF4 Gene

Disorders for HSF4 Gene

(1) OMIM Diseases for HSF4 Gene (602438)


  • Cataract 5, multiple types (CTRCT5) [MIM:116800]: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. CTRCT5 includes infantile, lamellar, zonular, nuclear, anterior polar, stellate, and Marner-type cataracts, among others. Finger malformation is observed in some kindreds. {ECO:0000269 PubMed:12089525, ECO:0000269 PubMed:16876512}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) Novoseek inferred disease relationships for HSF4 Gene

Disease -log(P) Hits PubMed IDs
cataract 58.9 12
shock 57.4 9

Relevant External Links for HSF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSF4: view

Publications for HSF4 Gene

  1. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. (PMID: 8972228) Nakai A. … Nagata K. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. (PMID: 10488131) Tanabe M. … Nakai A. (J. Biol. Chem. 1999) 2 3 4 23
  3. Novel HSF4 mutation causes congenital total white cataract in a Chinese family. (PMID: 16876512) Ke T. … Liu M. (Am. J. Ophthalmol. 2006) 3 4 23
  4. Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. (PMID: 12089525) Bu L. … Kong X. (Nat. Genet. 2002) 2 3 4
  5. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PMID: 16581800) Hu Y. … Mivechi N.F. (Mol. Cell. Biol. 2006) 3 4

Products for HSF4 Gene

Sources for HSF4 Gene

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