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HSF4 Gene

protein-coding   GIFtS: 62
GCID: GC16P067197

Heat Shock Transcription Factor 4

(Previous names: cataract, Marner)
(Previous symbol: CTM)
  See HSF4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Transcription Factor 41 2 3     HSTF 42 3
CTM1 2 5     CTRCT52 5
hHSF42 3     Cataract, Marner1
HSF 42 3     Heat Shock Factor Protein 42

External Ids:    HGNC: 52271   Entrez Gene: 32992   Ensembl: ENSG000001028787   OMIM: 6024385   UniProtKB: Q9ULV53   

Export aliases for HSF4 gene to outside databases

Previous GC identifers: GC16P057891 GC16P067576 GC16P066932 GC16P066974 GC16P065756 GC16P053070


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSF4 Gene:
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other
stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has
been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced
transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HSF4 Gene:
HSF4 (heat shock transcription factor 4) is a protein-coding gene. Diseases associated with HSF4 include lymphadenitis, and cervical adenitis. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HSF1.

UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses
transcription while the isoform HSF4B activates transcription

Gene Wiki entry for HSF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSF4 gene promoter:
         E2F-1   E2F   p53   ATF-2   c-Jun   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF4 promoter sequence
   Search Chromatin IP Primers for HSF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q21

HSF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P067197:  view genomic region     (about GC identifiers)

Start:
67,197,288 bp from pter      End:
67,203,848 bp from pter
Size:
6,561 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5 (See protein sequence)
Recommended Name: Heat shock factor protein 4  
Size: 492 amino acids; 53011 Da
Subunit: Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts
with ALKBH4, DUSP26, MAPK1, MAPK2 and MAP kinase p38
Secondary accessions: Q99472 Q9ULV6
Alternative splicing: 2 isoforms:  Q9ULV5-1   Q9ULV5-2   

Explore the universe of human proteins at neXtProt for HSF4: NX_Q9ULV5

Explore proteomics data for HSF4 at MOPED

Post-translational modifications: 

  • Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-2931
  • Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by
    phosphorylation on Ser-298. HSFA is not sumoylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035757.1  NP_001529.2  

    ENSEMBL proteins: 
     ENSP00000427832   ENSP00000403219   ENSP00000429580   ENSP00000428161   ENSP00000430631  
     ENSP00000428978   ENSP00000430947   ENSP00000463706   ENSP00000430299   ENSP00000430724  
     ENSP00000430211   ENSP00000428077   ENSP00000427963   ENSP00000430840   ENSP00000429486  
     ENSP00000264009   ENSP00000408815  

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    Cloud-Clone Corp. Proteins for HSF4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR027725 HSF_fam
     IPR011991 WHTH_DNA-bd_dom
     IPR000232 HSF_DNA-bd
     IPR027723 HSF4

    Graphical View of Domain Structure for InterPro Entry Q9ULV5

    ProtoNet protein and cluster: Q9ULV5

    1 Blocks protein domain: IPB000232 Heat shock factor (HSF)-type DNA-binding domain

    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
    Similarity: Belongs to the HSF family


    Find genes that share domains with HSF4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSF4_HUMAN, Q9ULV5
    Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses
    transcription while the isoform HSF4B activates transcription

         Genatlas biochemistry entry for HSF4:
    heat shock transcription factor 4,preferentially expressed in heart,brain,skeletal muscle,pancreas,potential
    repressor of genes for HS proteins and molecular chaperones with two alternatively spliced isoform
    HSF4a,HSF4b,the former acting as an inhibitor,the latter as an activator of tissue specific heat shock gene
    expression

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8972228
    GO:0019903protein phosphatase binding IPI16581800
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HSF4           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HSF4:
     Decreased influenza A H1N1 (A/  Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

         1 MGI mutant phenotype (inferred from 5 alleles(MGI details for Hsf4):
     vision/eye 

    Find genes that share phenotypes with HSF4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSF4: Hsf4tm1Xyk Hsf4tm1Anak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSF4

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    hsa-mir-26b-5p (MIRT029359)

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    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSF4_HUMAN, Q9ULV5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with HSF4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HSF4: 
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSF4 (Q9ULV52, 3 ENSP000002640094) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK2AP2O759562, 3MINT-8251208 I2D: score=2 
    NUDT21O438092, 3MINT-8264369 I2D: score=2 
    C5orf54Q8IZ132, 3, ENSP000003861844MINT-8259318 I2D: score=2 STRING: ENSP00000386184
    MAPK1P284823, ENSP000002158324I2D: score=3 STRING: ENSP00000215832
    DUSP26Q9BV473, ENSP000002562614I2D: score=2 STRING: ENSP00000256261
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001654eye development ----
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS8972228
    GO:0006357regulation of transcription from RNA polymerase II promoter ----

    Find genes that share ontologies with HSF4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSF4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSF4 gene (2 alternative transcripts): 
    NM_001040667.2  NM_001538.3  

    Unigene Cluster for HSF4:

    Heat shock transcription factor 4
    Hs.512156  [show with all ESTs]
    Unigene Representative Sequence: NM_001040667
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000518603 ENST00000522870 ENST00000522295 ENST00000434833 ENST00000522023
    ENST00000521314 ENST00000521624 ENST00000523562 ENST00000517685 ENST00000521374
    ENST00000584272 ENST00000523077 ENST00000517729 ENST00000519224 ENST00000517750
    ENST00000517680 ENST00000522027 ENST00000522459
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSF4
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    GenScript: all cDNA clones in your preferred vector (see all 2): HSF4 (NM_001040667)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HSF4
      QuantiFast Probe-based Assays in human, mouse, rat HSF4

    Additional mRNA sequence: 

    AB029348.1 AK225152.1 AK293631.1 AK296210.1 AK307211.1 AK308638.1 BC130383.1 D87673.1 

    13 DOTS entries:

    DT.100776610  DT.86852810  DT.95162422  DT.100776611  DT.95340077  DT.75102472  DT.95126720  DT.92021386 
    DT.91715687  DT.75102473  DT.95072645  DT.95162423  DT.70105481 

    Selected AceView cDNA sequences (see all 76):

    AI675519 BU783076 BF435646 BM768246 CR611910 AI695801 BM710035 AI684125 
    AI765859 BX102546 BX379491 AW295973 CA412687 AI564638 BQ771634 BC014414 
    AW510427 BG164451 BQ773906 CR598009 BQ673948 AI632815 AW269998 BQ014576 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSF4 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c
    SP1:                          -                       -     -                                               -                     
    SP2:                          -                       -                 -                                   -                     
    SP3:                                                                                            -     -     -                     
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for HSF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGTCCT
    HSF4 Expression
    About this image

    HSF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512156

    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
    Tissue specificity: Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other
    tissues

        Pathway & Disease-focused RT2 Profiler PCR Array including HSF4: 
              Heat Shock Proteins & Chaperones in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat HSF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSF4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf41 , 5 heat shock transcription factor 41, 5 86.19(n)1
    86.94(a)1
      8 (53.04 cM)5
    263861  NM_001256042.11  NP_001242971.11 
     1052698015 
    chicken
    (Gallus gallus)
    Aves HSF46
    Gallus gallus heat shock transcription factor 4 (H...
    44(a)
    1 ↔ 1
    11(2451762-2466446)
    lizard
    (Anolis carolinensis)
    Reptilia HSF46
    heat shock transcription factor 4
    55(a)
    1 ↔ 1
    5(108447303-108465268)
    zebrafish
    (Danio rerio)
    Actinopterygii hsf46
    heat shock transcription factor 4
    46(a)
    1 ↔ 1
    18(22523979-22534348) ENSDARG00000013251
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsf3 response to heat DNA binding 47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C10A.123 HSF-type DNA-binding domain 40(a)   I(11961851-11970016)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSF1(YGL073W)4 Trimeric heat shock transcription factor, activates more   --   7(368753-371254) 852806  NP_011442.1 
    corn
    (Zea mays)
    Liliopsida X82943.12   -- 73.33(n)    X82943.1 


    ENSEMBL Gene Tree for HSF4 (if available)
    TreeFam Gene Tree for HSF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSF4 gene
    HSF12  HSF22  
    2 SIMAP similar genes for HSF4 using alignment to 13 protein entries:     HSF4_HUMAN (see all proteins):
    HSF2    HSF1

    Find genes that share paralogs with HSF4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSF4 (see all 224)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0175594
    Cataract 5, multiple types (CTRCT5)4--see VAR_0175592 I V mis40--------
    VAR_0175604
    Cataract 5, multiple types (CTRCT5)4--see VAR_0175602 L P mis40--------
    VAR_0175584
    Cataract 5, multiple types (CTRCT5)4--see VAR_0175582 A D mis40--------
    VAR_0290184
    Cataract 5, multiple types (CTRCT5)4--see VAR_0290182 R H mis40--------
    rs762870291,2
    C--67197776(+) GGAACG/-GGGGG 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs799110441,2
    C--68201552(+) AAAAAG/AAAAAA 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1827281561,2
    --68201556(+) AGAAAA/GAAAAA 2 -- us2k10--------
    rs1878022521,2
    C--68201585(+) GTTCTC/GAACGT 2 -- us2k10--------
    rs133127201,2
    C,F,H--68201650(-) CTCTCC/TGGAAA 2 -- us2k119Minor allele frequency- T:0.10NS EA NA WA 2156
    rs1466877791,2
    --68201715(+) ATCTGA/TTGCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSF4 (67197288 - 67203848 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HSF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2887n71CNV Loss21882294
    dgv2888n71CNV Loss21882294
    nsv906794CNV Loss21882294
    nsv906803CNV Loss21882294
    dgv2886n71CNV Loss21882294
    nsv827707CNV Loss20364138
    dgv2885n71CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Human Gene Mutation Database (HGMD): HSF4
    Locus Specific Mutation Databases (LSDB): HSF4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602438   
    OMIM disorders: 116800  
    UniProtKB/Swiss-Prot: HSF4_HUMAN, Q9ULV5
  • Cataract 5, multiple types (CTRCT5) [MIM:116800]: An opacification of the crystalline lens of the eye
    that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a
    portion of the lens, and may be static or progressive. CTRCT5 includes infantile, lamellar, zonular, nuclear,
    anterior polar, stellate, and Marner-type cataracts, among others. Finger malformation is observed in some
    kindreds. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 16 diseases for HSF4:    
    About MalaCards
    lymphadenitis    cervical adenitis    intracranial hypotension    chronic purulent otitis media
    acute tympanitis    cataract 5, multiple types    cataract, zonular    suppurative lymphadenitis
    radiculopathy    parotitis    meningocele    spinal cord disease
    pharyngitis    otitis media    cataract 23    cataract

    14 diseases from the University of Copenhagen DISEASES database for HSF4:
    Cervical adenitis     Acute tympanitis     Chronic purulent otitis media     Tonsillitis
    Intracranial hypotension     Bronchitis     Meningocele     Pneumonia
    Radiculopathy     Chronic fatigue syndrome     Parotitis     Spinal cord disease
    Pharyngitis     Suppurative lymphadenitis

    Find genes that share disorders with HSF4           About GenesLikeMe

    2 Novoseek inferred disease relationships for HSF4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cataract 58.9 31 19224648 (5), 16876512 (4), 15277496 (2), 19874706 (1)
    shock 57.4 15 15308659 (2), 8972228 (2), 17483205 (1), 11585899 (1) (see all 7)

    Genetic Association Database (GAD): HSF4
    Human Genome Epidemiology (HuGE) Navigator: HSF4 (3 documents)

    Export disorders for HSF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSF4 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with HSF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. (PubMed id 8972228)1, 2, 3, 9 Nakai A.... Nagata K. (Mol. Cell. Biol. 1997)
    2. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing. (PubMed id 10488131)1, 2, 3, 9 Tanabe M....Nakai A. (J. Biol. Chem. 1999)
    3. Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract. (PubMed id 12089525)1, 2, 3 Bu L.... Kong X. (Nat. Genet. 2002)
    4. Novel HSF4 mutation causes congenital total white cataract in a Chinese family. (PubMed id 16876512)1, 2, 9 Ke T....Liu M. (Am. J. Ophthalmol. 2006)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. (PubMed id 16581800)1, 2 Hu Y. and Mivechi N.F. (Mol. Cell. Biol. 2006)
    7. A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract. (PubMed id 15277496)1, 9 Smaoui N....Hejtmancik J.F. (amp 2004)
    8. Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. (PubMed id 15308659)1, 9 Somasundaram T. and Bhat S.P. (J. Biol. Chem. 2004)
    9. Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study. (PubMed id 23329665)1 Jiang J....Guan H. (amp 2013)
    10. HSF4 regulates DLAD expression and promotes lens de-nucleation. (PubMed id 23507146)1 Cui X....Liu M. (Biochim. Biophys. Acta 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3299 HGNC: 5227 AceView: HSF4andFBXL8 Ensembl:ENSG00000102878 euGenes: HUgn3299
    ECgene: HSF4 H-InvDB: HSF4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HSF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HSF4 gene:
    Search GeneIP for patents involving HSF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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