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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSF2BP Gene

protein-coding   GIFtS: 49
GCID: GC21M044949

heat shock transcription factor 2 binding protein

  Search for HSF2BP
in our new
 Human Malady Compendium 
Biological research products
for HSF2BP
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Heat Shock Transcription Factor 2 Binding Protein2 11
Heat Shock Factor 2-Binding Protein2

External Ids:    HGNC: 52261   Entrez Gene: 110772   Ensembl: ENSG000001602077   OMIM: 6045545   UniProtKB: O750313   

Export aliases for HSF2BP gene to outside databases

Previous GC identifers: GC21M041458 GC21M041541 GC21M043805 GC21M043775 GC21M030317


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSF2BP:
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and
the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be
involved in modulating HSF2 activation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031
Function: May be involved in modulating HSF2 activation in testis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSF2BP gene promoter:
         NF-1   NF-1/L   AML1a   AP-4   Nkx5-1   HEN1   Ik-1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF2BP promoter sequence

   Search SABiosciences Chromatin IP Primers for HSF2BP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF2BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
HSF2BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF2BP gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M044949:   GeneLoc Nature:405,311-319
Start:
44,949,072 bp from pter       30,249,766 bp from centromere
End:
45,079,374 bp from pter 30,458,464 bp from centromere
Size:
130,303 bases 208,699 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AB007131
genomic clones: KB953G8


(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031 (See protein sequence)
Recommended Name: Heat shock factor 2-binding protein  
Size: 334 amino acids; 37645 Da
Subunit: Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the
N-terminal hydrophilic region of HSF2BP

Explore the universe of human proteins at neXtProt for HSF2BP: NX_O75031

Post-translational modifications:

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75031

  • HSF2BP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008962.1  
    ENSEMBL proteins: 
     ENSP00000291560   ENSP00000409585   ENSP00000443367  

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    Uscn Proteins for HSF2BP

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16780588


    HSF2BP for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HSF2BP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75031

    ProtoNet protein and cluster: O75031


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031
    Function: May be involved in modulating HSF2 activation in testis

    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSF2BP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HSF2BP (O750312, 3 ENSP000002915604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3, ENSP000003564054MINT-8251120 I2D: score=2 STRING: ENSP00000356405
    HSF2Q039333, ENSP000003574404I2D: score=1 STRING: ENSP00000357440
    UBE2IENSP000003248974STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9651507
    GO:0006950response to stress ----
    GO:0007283spermatogenesis TAS9651507


    HSF2BP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSF2BP
    Search CenterWatch for drugs/clinical trials and news about HSF2BP / HSF2B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSF2BP gene: 
    NM_007031.1  

    Unigene Cluster for HSF2BP:

    Heat shock transcription factor 2 binding protein
    Hs.406157  [show with all ESTs]
    Unigene Representative Sequence: AB007131
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291560(uc011aey.2 uc002zdi.3) ENST00000443485 ENST00000542962


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    hsa-miR-4272 hsa-miR-3613-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB007131.1 AK301795.1 AK314121.1 BC000153.2 CR457067.1 

    2 DOTS entries:

    DT.40119092  DT.40200876 

    23 AceView cDNA sequences:

    BC000153 NM_007031 AB007131 AI379165 AI990620 BE905674 BU621120 BG772229 
    BE018056 BI916735 BI459559 BU608336 BE301463 CR457067 AA398410 BE904566 
    AI656567 BX094612 BI829063 BG772303 AI074717 AA403061 AI074727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSF2BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTGTAGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HSF2BP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HSF2BP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSF2BP

    SOURCE GeneReport for Unigene cluster: Hs.406157

    UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF2BP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HSF2BP gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf2bp1 , 5 heat shock transcription factor 2 binding protein1, 5 85.43(n)1
    88.32(a)1
      17 (17.25 cM)5
    743771  NM_028902.11  NP_083178.11 
     319447695 
    chicken
    (Gallus gallus)
    Aves HSF2BP1 heat shock transcription factor 2 binding protein 75.03(n)
    74.01(a)
      418548  XM_416754.3  XP_416754.3 
    lizard
    (Anolis carolinensis)
    Reptilia HSF2BP6
    --
    73(a)
    1 ↔ 1
    3(136772015-136799621)
    zebrafish
    (Danio rerio)
    Actinopterygii hsf2bp1 heat shock transcription factor 2 binding protein 60.64(n)
    50(a)
      565831  XM_689091.2  XP_694183.2 


    ENSEMBL Gene Tree for HSF2BP (if available)
    TreeFam Gene Tree for HSF2BP (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2142 NCBI SNPs in HSF2BP are shown (see all 2142    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758362291,2
    F,--44948684(+) GCAACT/GCTCAC 1 -- ds50012Minor allele frequency- G:0.10WA EA 238
    rs1623971,2
    C,F,O,H,--44948764(+) TGGATG/TGCAAC 1 -- ds500120Minor allele frequency- T:0.04NS EA NA 2114
    rs1818233671,2
    --44948921(+) TTGTTA/GTAAGA 1 -- ds50010--------
    rs614750941,2
    C,--44949042(+) TATCAG/AGTTTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs119107471,2
    C,F,H,--44949116(+) GCACAA/CAAAAT 1 -- ut3111Minor allele frequency- C:0.07NA NS EA WA CSA 684
    rs1847904701,2
    --44949148(+) TCATCC/TGAAAT 1 -- ut310--------
    rs170045751,2
    C,F,--44949234(+) AATTGC/GTTTTC 1 -- ut31 ese34Minor allele frequency- G:0.02NA WA 260
    rs779002241,2
    --44949248(+) GAAATC/GTATCT 1 -- ut310--------
    rs1893972301,2
    --44949281(+) GTAGAC/TGGTTA 1 -- ut310--------
    rs1623981,2
    C,F,A,H,--44949285(+) ATGGTC/TATTCA 1 -- ut31 ese330Minor allele frequency- T:0.34EA NA MN NS WA CSA 3974

    HapMap Linkage Disequilibrium report for HSF2BP (44949072 - 45079374 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 21 variations for HSF2BP
         15/16 CNVs (see all 16): 6140 90814 67800 44058 79375 90813 22579 61980 103106 90812 43516 73646 38804 79376 39305
         5 Indels: 12249 79377 79378 26979 12248

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HSF2BP for disorders           About MalaCards

    HSF2BP for disorders           About GeneDecksing

    OMIM gene information: 604554    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: HSF2BP (1 document)

    Export disorders for HSF2BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSF2BP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HSF2BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel testis-specific protein that interacts with heat shock factor 2. (PubMed id 9651507)1, 2, 3, 9 Yoshima T.... Yanagi H. (1998)
    2. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    5. Monitoring protein-protein interactions in mammalian c ells by trans-SUMOylation. (PubMed id 21675959)1 Srivastav R.K....Niedenthal R. (2011)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11077 HGNC: 5226 AceView: HSF2BP Ensembl:ENSG00000160207 euGenes: HUgn11077
    ECgene: HSF2BP H-InvDB: HSF2BP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSF2BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSF2BP gene:
    Search GeneIP for patents involving HSF2BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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