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HSF2BP Gene

protein-coding   GIFtS: 49
GCID: GC21M044949

Heat Shock Transcription Factor 2 Binding Protein

  Search for HSF2BP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Heat Shock Transcription Factor 2 Binding Protein2 11
Heat Shock Factor 2 Binding Protein1
Heat Shock Factor 2-Binding Protein2

External Ids:    HGNC: 52261   Entrez Gene: 110772   Ensembl: ENSG000001602077   OMIM: 6045545   UniProtKB: O750313   

Export aliases for HSF2BP gene to outside databases

Previous GC identifers: GC21M041458 GC21M041541 GC21M043805 GC21M043775 GC21M030317


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSF2BP Gene:
HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of
HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may
therefore be involved in modulating HSF2 activation. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSF2BP Gene:
HSF2BP (heat shock transcription factor 2 binding protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031
Function: May be involved in modulating HSF2 activation in testis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSF2BP gene promoter:
         NF-1   NF-1/L   AML1a   AP-4   Nkx5-1   HEN1   Ik-1   ATF   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF2BP promoter sequence

   Search Chromatin IP Primers for HSF2BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSF2BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
HSF2BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF2BP gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M044949:   GeneLoc Nature:405,311-319
Start:
44,949,072 bp from pter       30,249,766 bp from centromere
End:
45,079,374 bp from pter 30,458,464 bp from centromere
Size:
130,303 bases 208,699 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AB007131
genomic clones: KB953G8


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031 (See protein sequence)
Recommended Name: Heat shock factor 2-binding protein  
Size: 334 amino acids; 37645 Da
Subunit: Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the
N-terminal hydrophilic region of HSF2BP

Explore the universe of human proteins at neXtProt for HSF2BP: NX_O75031

Explore proteomics data for HSF2BP at MOPED

Post-translational modifications: 

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSF2BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008962.1  
    ENSEMBL proteins: 
     ENSP00000291560   ENSP00000409585   ENSP00000443367  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011989 ARM-like
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry O75031

    ProtoNet protein and cluster: O75031


    HSF2BP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSF2B_HUMAN, O75031
    Function: May be involved in modulating HSF2 activation in testis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
         
    HSF2BP for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Hsf2bp (no phenotypes)

    HSF2BP for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSF2BP
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    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate HSF2BP:
    hsa-miR-4272 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHSF2BP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IDA16780588

    HSF2BP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSF2BP
    Interactions:

        GeneGlobe Interaction Network for HSF2BP

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HSF2BP (O750312, 3 ENSP000002915604) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC73Q6P1J92, 3, ENSP000003564054MINT-8251120 I2D: score=2 STRING: ENSP00000356405
    HSF2Q039333, ENSP000003574404I2D: score=1 STRING: ENSP00000357440
    UBE2IENSP000003248974STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS9651507
    GO:0006950response to stress ----
    GO:0007283spermatogenesis TAS9651507

    HSF2BP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSF2BP (HSF2B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSF2BP gene: 
    NM_007031.1  

    Unigene Cluster for HSF2BP:

    Heat shock transcription factor 2 binding protein
    Hs.406157  [show with all ESTs]
    Unigene Representative Sequence: AB007131
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291560(uc011aey.2 uc002zdi.3) ENST00000443485 ENST00000542962

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate HSF2BP:
    hsa-miR-4272 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHSF2BP 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HSF2BP
      QuantiFast Probe-based Assays in human, mouse, rat HSF2BP

    Additional mRNA sequence: 

    AB007131.1 AK301795.1 AK314121.1 BC000153.2 CR457067.1 

    2 DOTS entries:

    DT.40119092  DT.40200876 

    23 AceView cDNA sequences:

    AI990620 AI379165 BE905674 BC000153 BU621120 NM_007031 AB007131 AI656567 
    BE018056 BI459559 BU608336 BI916735 CR457067 BG772229 BI829063 BE301463 
    BE904566 AA398410 BX094612 AI074717 BG772303 AA403061 AI074727 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSF2BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGTAGGT
    HSF2BP Expression
    About this image


    HSF2BP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Testis (Reproductive System)
    HSF2BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSF2BP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406157

    UniProtKB/Swiss-Prot: HSF2B_HUMAN, O75031
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HSF2BP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf2bp1 , 5 heat shock transcription factor 2 binding protein1, 5 85.43(n)1
    88.32(a)1
      17 (17.25 cM)5
    743771  NM_028902.11  NP_083178.11 
     319447695 
    chicken
    (Gallus gallus)
    Aves HSF2BP1 heat shock transcription factor 2 binding protein 75.05(n)
    74.23(a)
      418548  XM_416754.4  XP_416754.4 
    lizard
    (Anolis carolinensis)
    Reptilia HSF2BP6
    heat shock transcription factor 2 binding protein
    73(a)
    1 ↔ 1
    3(136772009-136799621)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsf2bp1 heat shock transcription factor 2 binding protein 59.54(n)
    54.93(a)
      100495665  XM_002942725.2  XP_002942771.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hsf2bp1 heat shock transcription factor 2 binding protein 60.64(n)
    50(a)
      565831  XM_689091.3  XP_694183.3 


    ENSEMBL Gene Tree for HSF2BP (if available)
    TreeFam Gene Tree for HSF2BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSF2BP (see all 2506)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs758362291,2
    C,F--44948684(+) GCAACT/GCTCAC 1 -- ds50012Minor allele frequency- G:0.10WA EA 238
    rs1623971,2
    C,F,O,H--44948764(+) TGGATG/TGCAAC 1 -- ds500120Minor allele frequency- T:0.04NS EA NA 2114
    rs1818233671,2
    --44948921(+) TTGTTA/GTAAGA 1 -- ds50010--------
    rs614750941,2
    C,F--44949042(+) TATCAG/AGTTTA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs119107471,2
    C,F,H--44949116(+) GCACAA/CAAAAT 1 -- ut3111Minor allele frequency- C:0.07NA NS EA WA CSA 684
    rs1847904701,2
    --44949148(+) TCATCC/TGAAAT 1 -- ut310--------
    rs170045751,2
    C,F--44949234(+) AATTGC/GTTTTC 1 -- ut31 ese34Minor allele frequency- G:0.02NA WA 260
    rs779002241,2
    C--44949248(+) GAAATC/GTATCT 1 -- ut310--------
    rs1893972301,2
    --44949281(+) GTAGAC/TGGTTA 1 -- ut310--------
    rs1623981,2
    C,F,A,H--44949285(+) ATGGTC/TATTCA 1 -- ut31 ese330Minor allele frequency- T:0.34EA NA MN NS WA CSA 3974

    HapMap Linkage Disequilibrium report for HSF2BP (44949072 - 45079374 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HSF2BP (see all 33):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723613CNV Deletion23290073
    esv2659710CNV Deletion23128226
    esv2723612CNV Deletion23290073
    esv2108372CNV Deletion18987734
    esv2421821CNV Deletion20811451
    esv2723611CNV Deletion23290073
    nsv436338CNV Deletion17901297
    esv1180297CNV Deletion17803354
    esv2723610CNV Deletion23290073
    esv2807CNV Deletion18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604554    OMIM disorders: --


    HSF2BP for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSF2BP
    Human Genome Epidemiology (HuGE) Navigator: HSF2BP (1 document)

    Export disorders for HSF2BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSF2BP gene integrated from 10 sources:
    (articles sorted by number of sources associating them with HSF2BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel testis-specific protein that interacts with heat shock factor 2. (PubMed id 9651507)1, 2, 3, 9 Yoshima T.... Yanagi H. (Gene 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PubMed id 17709345)1, 2 Jakobs A.... Niedenthal R. (Nucleic Acids Res. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    6. Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. (PubMed id 21675959)1 Srivastav R.K....Niedenthal R. (Biochem. J. 2011)
    7. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    8. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PubMed id 16780588)1 Hu Y.H....Janitz M. (BMC Genomics 2006)
    9. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1 Lehner B. and Sanderson C.M. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11077 HGNC: 5226 AceView: HSF2BP Ensembl:ENSG00000160207 euGenes: HUgn11077
    ECgene: HSF2BP H-InvDB: HSF2BP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSF2BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSF2BP gene:
    Search GeneIP for patents involving HSF2BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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