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Aliases for HSF2BP Gene

Aliases for HSF2BP Gene

  • Heat Shock Transcription Factor 2 Binding Protein 2 3
  • Heat Shock Factor 2 Binding Protein 2

External Ids for HSF2BP Gene

Summaries for HSF2BP Gene

Entrez Gene Summary for HSF2BP Gene

  • HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSF2BP Gene

HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HSF2BP Gene

  • May be involved in modulating HSF2 activation in testis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF2BP Gene

Genomics for HSF2BP Gene

Genomic Location for HSF2BP Gene

Start:
43,529,186 bp from pter
End:
43,659,493 bp from pter
Size:
130,308 bases
Orientation:
Minus strand

Genomic View for HSF2BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF2BP Gene

Regulatory Elements for HSF2BP Gene

Proteins for HSF2BP Gene

  • Protein details for HSF2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75031-HSF2B_HUMAN
    Recommended name:
    Heat shock factor 2-binding protein
    Protein Accession:
    O75031
    Secondary Accessions:
    • B4DX36

    Protein attributes for HSF2BP Gene

    Size:
    334 amino acids
    Molecular mass:
    37645 Da
    Quaternary structure:
    • Associates with HSF2. The interaction seems to occur between the trimerization domain of HSF2 and the N-terminal hydrophilic region of HSF2BP

    Alternative splice isoforms for HSF2BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF2BP Gene

Proteomics data for HSF2BP Gene at MOPED

Post-translational modifications for HSF2BP Gene

  • Sumoylated by UBE2I in response to MEKK1-mediated stimuli.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF2BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSF2BP Gene

Domains for HSF2BP Gene

Protein Domains for HSF2BP Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with HSF2BP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HSF2BP Gene

Function for HSF2BP Gene

Molecular function for HSF2BP Gene

UniProtKB/Swiss-Prot Function: May be involved in modulating HSF2 activation in testis

Gene Ontology (GO) - Molecular Function for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HSF2BP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSF2BP Gene

Localization for HSF2BP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF2BP Gene COMPARTMENTS Subcellular localization image for HSF2BP gene
Compartment Confidence
cytosol 5
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16780588
genes like me logo Genes that share ontologies with HSF2BP: view

Pathways for HSF2BP Gene

SuperPathways for HSF2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSF2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS 9651507
GO:0007283 spermatogenesis TAS 9651507
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with HSF2BP: view

No data available for Pathways by source for HSF2BP Gene

Transcripts for HSF2BP Gene

Unigene Clusters for HSF2BP Gene

Heat shock transcription factor 2 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF2BP Gene

No ASD Table

Relevant External Links for HSF2BP Gene

GeneLoc Exon Structure for
HSF2BP
ECgene alternative splicing isoforms for
HSF2BP

Expression for HSF2BP Gene

mRNA expression in normal human tissues for HSF2BP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSF2BP Gene

This gene is overexpressed in Testis (25.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSF2BP Gene

SOURCE GeneReport for Unigene cluster for HSF2BP Gene Hs.406157

mRNA Expression by UniProt/SwissProt for HSF2BP Gene

O75031-HSF2B_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with HSF2BP: view

Orthologs for HSF2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for HSF2BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSF2BP 36
  • 99.4 (n)
  • 99.4 (a)
HSF2BP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSF2BP 36
  • 86.63 (n)
  • 93.11 (a)
HSF2BP 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSF2BP 36
  • 88.82 (n)
  • 93.11 (a)
HSF2BP 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsf2bp 36
  • 85.43 (n)
  • 88.32 (a)
Hsf2bp 16
Hsf2bp 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSF2BP 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF2BP 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf2bp 36
  • 85.23 (n)
  • 88.02 (a)
chicken
(Gallus gallus)
Aves HSF2BP 36
  • 75.05 (n)
  • 74.23 (a)
HSF2BP 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF2BP 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsf2bp 36
  • 59.54 (n)
  • 54.93 (a)
zebrafish
(Danio rerio)
Actinopterygii hsf2bp 36
  • 60.64 (n)
  • 50 (a)
hsf2bp 37
  • 41 (a)
OneToOne
Species with no ortholog for HSF2BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSF2BP Gene

ENSEMBL:
Gene Tree for HSF2BP (if available)
TreeFam:
Gene Tree for HSF2BP (if available)

Paralogs for HSF2BP Gene

No data available for Paralogs for HSF2BP Gene

Variants for HSF2BP Gene

Sequence variations from dbSNP and Humsavar for HSF2BP Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs141521 -- 43,543,806(-) TCCTC(C/T)TGGTC intron-variant
rs162343 -- 43,537,192(+) AAGCT(A/G)TATCA intron-variant
rs162344 -- 43,534,642(-) tctgt(C/T)gctct intron-variant
rs162345 -- 43,534,275(-) gtttc(A/C)tgttt intron-variant
rs162346 -- 43,532,360(-) ggggg(A/C/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF2BP Gene

Variant ID Type Subtype PubMed ID
dgv4758n71 CNV Loss 21882294
nsv913873 CNV Loss 21882294
nsv521700 CNV Loss 19592680
nsv470903 CNV Loss 18288195
nsv459289 CNV Loss 19166990
nsv511632 CNV Loss 21212237
nsv3537 CNV Loss 18451855
nsv436338 CNV Deletion 17901297
esv2474541 CNV Loss 19546169
esv2627317 CNV Deletion 19546169
nsv820925 CNV Deletion 20802225
nsv828905 CNV Gain+Loss 20364138
esv2108372 CNV Deletion 18987734
esv1010827 CNV Gain 20482838
esv29530 CNV Gain 19812545
nsv512641 CNV Loss 21212237
esv2723610 CNV Deletion 23290073
nsv828906 CNV Loss 20364138
esv2421821 CNV Deletion 20811451
nsv442789 CNV CNV 18776908
esv2807 CNV Deletion 18987735
esv7883 CNV Loss 19470904
nsv514957 CNV Loss 21397061
nsv834106 CNV Loss 17160897
esv27911 CNV Loss 19812545
dgv109n6 CNV Loss 16902084
esv1180297 CNV Deletion 17803354
nsv187429 CNV Loss 16902084
nsv913874 CNV Loss 21882294
esv2723611 CNV Deletion 23290073
esv2659710 CNV Deletion 23128226
esv2723612 CNV Deletion 23290073
esv2723613 CNV Deletion 23290073

Relevant External Links for HSF2BP Gene

HapMap Linkage Disequilibrium report
HSF2BP

Disorders for HSF2BP Gene

Relevant External Links for HSF2BP

Genetic Association Database (GAD)
HSF2BP
Human Genome Epidemiology (HuGE) Navigator
HSF2BP
genes like me logo Genes that share disorders with HSF2BP: view

No data available for UniProtKB/Swiss-Prot for HSF2BP Gene

Publications for HSF2BP Gene

  1. Novel testis-specific protein that interacts with heat shock factor 2. (PMID: 9651507) Yoshima T. … Yanagi H. (Gene 1998) 2 3 4 23
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation. (PMID: 17709345) Jakobs A. … Niedenthal R. (Nucleic Acids Res. 2007) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HSF2BP Gene

Sources for HSF2BP Gene

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