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HSF2 Gene

protein-coding   GIFtS: 62
GCID: GC06P122762

Heat Shock Transcription Factor 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Transcription Factor 21 2 3
HSF 22 3
HSTF 22 3
Heat Shock Factor Protein 22
HSTF23

External Ids:    HGNC: 52251   Entrez Gene: 32982   Ensembl: ENSG000000251567   OMIM: 1405815   UniProtKB: Q039333   

Export aliases for HSF2 gene to outside databases

Previous GC identifers: GC06P122491 GC06P122678 GC06P122702 GC06P122703 GC06P120297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSF2 Gene:
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the
heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock
response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for HSF2 Gene:
HSF2 (heat shock transcription factor 2) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HSF4.

UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates
transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Wiki entry for HSF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSF2 gene promoter:
         Sp1   C/EBPalpha   FOXL1   RORalpha1   CHOP-10   PPAR-gamma1   HFH-1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF2 promoter sequence
   Search Chromatin IP Primers for HSF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22

HSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P122762:  view genomic region     (about GC identifiers)

Start:
122,720,691 bp from pter      End:
122,754,264 bp from pter
Size:
33,574 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933 (See protein sequence)
Recommended Name: Heat shock factor protein 2  
Size: 536 amino acids; 60348 Da
Subunit: DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer
Secondary accessions: B4DGJ4 Q0VAH9 Q2M1K4 Q9H445
Alternative splicing: 2 isoforms:  Q03933-1   Q03933-2   

Explore the universe of human proteins at neXtProt for HSF2: NX_Q03933

Explore proteomics data for HSF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys51, Lys54
  • Modification sites at PhosphoSitePlus

  • See HSF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129036.1  NP_001230023.1  NP_004497.1  

    ENSEMBL proteins: 
     ENSP00000357440   ENSP00000477405   ENSP00000400380  

    HSF2 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for HSF2
    Novus Biologicals HSF2 Protein
    Novus Biologicals HSF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HSF2

     
    Search eBioscience for Proteins for HSF2 

     
    antibodies-online proteins for HSF2 (8 products) 

     
    antibodies-online peptides for HSF2

    HSF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSF2
    R&D Systems Antibodies for HSF2
    OriGene Antibodies for HSF2
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    Novus Biologicals HSF2 Antibodies
    Abcam antibodies for HSF2
    Cloud-Clone Corp. Antibodies for HSF2
    ThermoFisher Antibodies for HSF2
    antibodies-online antibodies for HSF2 (84 products) 

    HSF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSF2
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    GenScript Custom Assay Services for HSF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSF2
    Cloud-Clone Corp. CLIAs for HSF2
    Search eBioscience for ELISAs for HSF2 
    antibodies-online kits for HSF2 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR027725 HSF_fam
     IPR011991 WHTH_DNA-bd_dom
     IPR000232 HSF_DNA-bd
     IPR027712 HSF2
     IPR010542 Vert_HSTF_C

    Graphical View of Domain Structure for InterPro Entry Q03933

    ProtoNet protein and cluster: Q03933

    2 Blocks protein domains:
    IPB000232 Heat shock factor (HSF)-type DNA-binding domain
    IPB010542 Vertebrate heat shock transcription factor


    UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933
    Similarity: Belongs to the HSF family


    Find genes that share domains with HSF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSF2_HUMAN, Q03933
    Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates
    transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA10561509
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS1871106
    GO:0042803protein homodimerization activity IEA--
         
    Find genes that share ontologies with HSF2           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hsf2):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body  mortality/aging 
     nervous system  normal  other  reproductive system 

    Find genes that share phenotypes with HSF2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hsf2tm1Ijb for HSF2

       genOway: Develop your customized and physiologically relevant rodent model for HSF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSF2:
    hsa-mir-24-3p (MIRT030504), hsa-mir-26b-5p (MIRT029326), hsa-let-7a-5p (MIRT052530), hsa-let-7b-5p (MIRT052083), hsa-mir-18a-5p (MIRT005361)

    Block miRNA regulation of human, mouse, rat HSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSF2 (see all 16):
    hsa-miR-4328 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-548k hsa-miR-624* hsa-miR-3692 hsa-miR-144 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHSF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSF2
    Predesigned siRNA for gene silencing in human, mouse, rat HSF2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for HSF2

    Clone
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    OriGene clones in human, mouse for HSF2 (see all 12)
    OriGene ORF clones in mouse, rat for HSF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSF2 (NM_004506)
    Sino Biological Human cDNA Clone for HSF2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HSF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSF2_HUMAN, Q03933: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon
    activation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with HSF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HSF2
        Proteolysis Putative SUMO-1 pathway



        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSF2: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSF2 (Q039333 ENSP000003574404) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    NCAPGQ9BPX33, ENSP000002514964I2D: score=2 STRING: ENSP00000251496
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    FZR1Q9UM113, ENSP000003785294I2D: score=1 STRING: ENSP00000378529
    HSF2BPO750313, ENSP000002915604I2D: score=1 STRING: ENSP00000291560
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS1871106
    GO:0006950response to stress IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA10561509

    Find genes that share ontologies with HSF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSF2

    6 Novoseek inferred chemical compound relationships for HSF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 59.7 3 15023536 (1), 9710593 (1), 11585899 (1)
    leucine 24.7 2 17688198 (1), 9651507 (1)
    adriamycin 16.4 1 14761432 (1)
    threonine 1.25 2 17688198 (1)
    estrogen 0 4 7748806 (2), 17395694 (1)
    serine 0 2 17688198 (1)



    Find genes that share compounds with HSF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSF2 gene (3 alternative transcripts): 
    NM_001135564.1  NM_001243094.1  NM_004506.3  

    Unigene Cluster for HSF2:

    Heat shock transcription factor 2
    Hs.158195  [show with all ESTs]
    Unigene Representative Sequence: NM_004506
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368455(uc003pyt.4) ENST00000465214 ENST00000452194(uc003pyu.2 uc003pyv.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat HSF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSF2 (see all 16):
    hsa-miR-4328 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-548k hsa-miR-624* hsa-miR-3692 hsa-miR-144 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHSF2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HSF2
    Predesigned siRNA for gene silencing in human, mouse, rat HSF2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HSF2 (NM_004506)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF2
    Primer
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    OriGene qPCR primer pairs and template standards for HSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for HSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSF2
      QuantiTect SYBR Green Assays in human, mouse, rat HSF2
      QuantiFast Probe-based Assays in human, mouse, rat HSF2

    Additional mRNA sequence: 

    AK225593.1 AK225594.1 AK294624.1 AK316377.1 BC005329.1 BC064622.1 BC112323.1 BC121050.1 
    BC121051.1 BC128420.1 M65217.1 

    11 DOTS entries:

    DT.97842613  DT.95376152  DT.97782494  DT.455204  DT.121365417  DT.92431480  DT.95376155  DT.95130525 
    DT.100833409  DT.92036683  DT.100833411 

    Selected AceView cDNA sequences (see all 164):

    CR626481 M65217 BM724977 AI056677 AW949779 BM833569 CR623759 BM142207 
    BQ011613 AI480249 AI270358 BM353998 N46665 AL044736 AU129397 BC064622 
    BM474677 BG055070 CK819999 AI923911 CR597278 BP378257 BE645851 BM680190 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -                                                     -     -                                         -                     
    SP2:              -     -                                                                                                                           
    SP3:                                                                                                                                                
    SP4:                                                                                -                                                               
    SP5:                                                                          -     -                                   -     -                     


    ECgene alternative splicing isoforms for HSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAACAGGA
    HSF2 Expression
    About this image

    HSF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158195
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSF2: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSF2
    OriGene qSTAR qPCR primer pairs in human, mouse for HSF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSF2
    QuantiTect SYBR Green Assays in human, mouse, rat HSF2
    QuantiFast Probe-based Assays in human, mouse, rat HSF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf21 , 5 heat shock factor 21, 5 90.57(n)1
    94.57(a)1
      10 (29.19 cM)5
    155001  NM_008297.31  NP_032323.31 
     574863855 
    chicken
    (Gallus gallus)
    Aves HSF21 heat shock transcription factor 2 76.2(n)
    81.25(a)
      421724  NM_001167764.1  NP_001161236.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSF26
    heat shock transcription factor 2
    73(a)
    1 ↔ 1
    1(182418768-182444958)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985111.12   -- 69.58(n)    CA985111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsf22 heat shock factor 2 76.49(n)   140427  BC064280.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsf3 response to heat DNA binding 47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C10A.123 HSF-type DNA-binding domain 28(a)   I(11961851-11970016)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKN7(YHR206W)4 Nuclear response regulator and transcription factor; more   --   8(512732-514600) 856613  NP_012076.1 


    ENSEMBL Gene Tree for HSF2 (if available)
    TreeFam Gene Tree for HSF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSF2 gene
    HSF42  HSF12  
    2 SIMAP similar genes for HSF2 using alignment to 4 protein entries:     HSF2_HUMAN (see all proteins):
    HSF1    HSF4

    Find genes that share paralogs with HSF2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HSF2
    PGOHUM00000239466


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSF2 (see all 702)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411771291,2
    C--122720477(+) TAATGA/CCATGA 3 -- us2k10--------
    rs93726951,2
    C,F,A--122720486(+) GAAAGT/CAGGCC 3 -- us2k115Minor allele frequency- C:0.13NA NS WA EA 696
    rs1157406071,2
    C,F--122720493(+) GGCCAC/AATTTC 3 -- us2k11Minor allele frequency- A:0.05WA 118
    rs455412421,2
    C,F--122720498(+) CATTTC/ACTCCT 3 -- us2k15Minor allele frequency- A:0.00NS 188
    rs1508799751,2
    --122720581(+) TGCTCA/GTTCTG 3 -- us2k10--------
    rs454964011,2
    C,F--122720669(+) CCTTAC/TCACCT 3 -- us2k15Minor allele frequency- T:0.00NS 190
    rs1839340911,2
    --122720780(+) TGTTTA/CTTGAG 3 -- us2k10--------
    rs1888281911,2
    --122720861(+) GCTCAA/GTAAAG 3 -- us2k10--------
    rs1500346801,2
    --122720868(+) AAAGCC/TTGGGT 3 -- us2k10--------
    rs1473334141,2
    --122720936(+) CAGAAA/TCTTCT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSF2 (122720691 - 122754264 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HSF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2006e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HSF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSF2
    DNA2.0 Custom Variant and Variant Library Synthesis for HSF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140581    OMIM disorders: --


    Find genes that share disorders with HSF2           About GenesLikeMe

    4 Novoseek inferred disease relationships for HSF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 78.6 133 11585899 (6), 17213196 (4), 12813038 (4), 8114740 (3) (see all 45)
    erythroleukemia 71.6 17 8114740 (1), 9738016 (1), 11557063 (1), 17213196 (1) (see all 10)
    neurodegenerative diseases 10.3 1 16048840 (1)
    breast cancer 0 1 9367858 (1)

    Genetic Association Database (GAD): HSF2
    Human Genome Epidemiology (HuGE) Navigator: HSF2 (4 documents)

    Export disorders for HSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSF2 gene, integrated from 10 sources (see all 107):
    (articles sorted by number of sources associating them with HSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PubMed id 1871106)1, 2, 3, 9 Schuetz T.J.... Kingston R.E. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PubMed id 8339932)1, 2, 9 Sheldon L. and Kingston R.E. (Genes Dev. 1993)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PubMed id 18978678)1, 4 Vieira A.R....Marazita M.L. (Genet. Med. 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. (PubMed id 19129477)1, 9 Sandqvist A....Sistonen L. (Mol. Biol. Cell 2009)
    8. MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation. (PubMed id 18211895)1, 9 Zhang J....Sarge K.D. (J. Biol. Chem. 2008)
    9. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. (PubMed id 17213196)1, 9 Ostling P....Sistonen L. (J. Biol. Chem. 2007)
    10. Identification of the PP2A-interacting region of heat shock transcription factor 2. (PubMed id 17688198)1, 9 Xing H....Sarge K.D. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3298 HGNC: 5225 AceView: HSF2 Ensembl:ENSG00000025156 euGenes: HUgn3298
    ECgene: HSF2 H-InvDB: HSF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSF2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hsf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSF2 gene:
    Search GeneIP for patents involving HSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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