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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSF2 Gene

protein-coding   GIFtS: 60
GCID: GC06P122762

heat shock transcription factor 2

 Explore 10 diseases affiliated with
HSF2 via our new
 Human Malady Compendium 
Biological research products
for HSF2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Heat Shock Transcription Factor 21 2 3
HSF 22 3
HSTF 22 3
Heat Shock Factor Protein 22
HSTF23

External Ids:    HGNC: 52251   Entrez Gene: 32982   Ensembl: ENSG000000251567   OMIM: 1405815   UniProtKB: Q039333   

Export aliases for HSF2 gene to outside databases

Previous GC identifers: GC06P122491 GC06P122678 GC06P122702 GC06P122703 GC06P120297


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSF2:
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the
heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response
genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Wiki entry for HSF2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSF2 gene promoter:
         Sp1   C/EBPalpha   FOXL1   RORalpha1   CHOP-10   PPAR-gamma1   HFH-1   FOXO1a   PPAR-gamma2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.31   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22

HSF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P122762:  view genomic region     (about GC identifiers)

Start:
122,720,691 bp from pter      End:
122,754,264 bp from pter
Size:
33,574 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933 (See protein sequence)
Recommended Name: Heat shock factor protein 2  
Size: 536 amino acids; 60348 Da
Subunit: DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth and moves to the nucleus upon
activation
Secondary accessions: B4DGJ4 Q0VAH9 Q2M1K4 Q9H445
Alternative splicing: 2 isoforms:  Q03933-1   Q03933-2   

Explore the universe of human proteins at neXtProt for HSF2: NX_Q03933

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q03933

  • HSF2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129036.1  NP_001230023.1  NP_004497.1  

    ENSEMBL proteins: 
     ENSP00000357440   ENSP00000400380  

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    Novus Biologicals HSF2 Protein
    Novus Biologicals HSF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HSF2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--


    HSF2 for ontologies           About GeneDecksing



    HSF2 Antibody Products: 
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    Uscn ELISAs and CLIAs for HSF2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HSF2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR000232 HSF_DNA-bd
     IPR010542 Vert_HS_TF

    Graphical View of Domain Structure for InterPro Entry Q03933

    ProtoNet protein and cluster: Q03933

    2 Blocks protein families:
    IPB000232 Heat shock factor (HSF)-type DNA-binding domain
    IPB010542 Vertebrate heat shock transcription factor


    UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933
    Similarity: Belongs to the HSF family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HSF2_HUMAN, Q03933
    Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.
    In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

    10/498 SABiosciences Target genes for HSF2 (see all 498):
    ABCA4 ABCD2 ACSBG2 AGAP11 AHCTF1 AICDA ANKRD34B ANO5 ANP32C AQP12A

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSF2
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSF2 (see all 16):
    hsa-miR-4328 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-548k hsa-miR-624* hsa-miR-3692 hsa-miR-144 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHSF2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF2 (see all 7)
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA10561509
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003713transcription coactivator activity TAS1871106
    GO:0042803protein homodimerization activity IEA--


    HSF2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hsf2tm1Ijb for HSF2
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hsf2):
     cardiovascular system  cellular  endocrine/exocrine gland  growth/size  mortality/aging 
     nervous system  normal  other  reproductive system 

    HSF2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Proteolysis Putative SUMO-1 pathway
    Proteolysis Putative SUMO-1 pathway1.00
    Proteolysis_Putative SUMO-1 pathway0.97

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HSF2
        Proteolysis Putative SUMO-1 pathway


    1 GeneGo (Thomson Reuters) Pathway for HSF2
        Proteolysis Putative SUMO-1 pathway



    HSF2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for HSF2 (Q039333 ENSP000003574404) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    NCAPGQ9BPX33, ENSP000002514964I2D: score=2 STRING: ENSP00000251496
    CUL3Q136183, ENSP000002644144I2D: score=1 STRING: ENSP00000264414
    FZR1Q9UM113, ENSP000003785294I2D: score=1 STRING: ENSP00000378529
    HSF2BPO750313, ENSP000002915604I2D: score=1 STRING: ENSP00000291560
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS1871106
    GO:0006950response to stress IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA10561509


    HSF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSF2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSF2
    6 Novoseek chemical compound relationships for HSF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 59.7 3 15023536 (1), 9710593 (1), 11585899 (1)
    leucine 24.7 2 17688198 (1), 9651507 (1)
    adriamycin 16.4 1 14761432 (1)
    threonine 1.25 2 17688198 (1)
    estrogen 0 4 7748806 (2), 17395694 (1)
    serine 0 2 17688198 (1)

    Search CenterWatch for drugs/clinical trials and news about HSF2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSF2 gene (3 alternative transcripts): 
    NM_001135564.1  NM_001243094.1  NM_004506.3  

    Unigene Cluster for HSF2:

    Heat shock transcription factor 2
    Hs.158195  [show with all ESTs]
    Unigene Representative Sequence: NM_004506
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368455(uc003pyt.4) ENST00000465214 ENST00000452194(uc003pyu.2 uc003pyv.2)


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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate HSF2 (see all 16):
    hsa-miR-4328 hsa-miR-520d-5p hsa-miR-218-2* hsa-miR-548k hsa-miR-624* hsa-miR-3692 hsa-miR-144 hsa-miR-3613-3p
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF2
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    Additional cDNA sequence: 

    AK225593.1 AK225594.1 AK294624.1 AK316377.1 BC005329.1 BC064622.1 BC112323.1 BC121050.1 
    BC121051.1 BC128420.1 M65217.1 

    11 DOTS entries:

    DT.97842613  DT.95376152  DT.97782494  DT.455204  DT.121365417  DT.92431480  DT.95376155  DT.95130525 
    DT.100833409  DT.92036683  DT.100833411 

    24/164 AceView cDNA sequences (see all 164):

    BQ924303 AI270358 BM142207 BM353998 AL534186 CR623759 AI923911 BC064622 
    BQ011613 AI480249 CR597278 BG055070 CK819999 CR626481 BP378257 BM833569 
    CR604546 BM474677 M65217 BM680190 AI056677 BE645851 AL044736 BM724977 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for HSF2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:              -     -                                                     -     -                                         -                     
    SP2:              -     -                                                                                                                           
    SP3:                                                                                                                                                
    SP4:                                                                                -                                                               
    SP5:                                                                          -     -                                   -     -                     


    ECgene alternative splicing isoforms for HSF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAACAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HSF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSF2

    SOURCE GeneReport for Unigene cluster: Hs.158195
        SABiosciences Expression via Pathway-Focused PCR Arrays including HSF2: 
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSF2 gene from 8/28 species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HSF21 heat shock transcription factor 2 76.2(n)
    81.25(a)
      421724  NM_001167764.1  NP_001161236.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSF26
    --
    72(a)
    1 ↔ 1
    1(182418768-182444916)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA985111.12   -- 69.58(n)    CA985111.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsf22 heat shock factor 2 76.49(n)   140427  BC064280.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsf3 response to heat DNA binding 47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C10A.123 HSF-type DNA-binding domain 28(a)   I(11961851-11970016)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSFA7A1 heat stress transcription factor A-7a 50.09(n)
    36.16(a)
      824354  NM_115050.1  NP_190759.1 
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 25)
    HSF-type DNA-binding domain containing protein, ex...
    CPuORF39 - conserved peptide uORF-containing trans...
    (see all 25)
    23(a)
    20(a)
    (see all 25)
    many ↔ many
    many ↔ many
    (see all 25)
    1(30581441-30582699)
    9(17220425-17227960)


    ENSEMBL Gene Tree for HSF2 (if available)
    TreeFam Gene Tree for HSF2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSF2 gene
    HSF42  HSF12  
    2 SIMAP similar genes for HSF2 using alignment to 3 protein entries:     HSF2_HUMAN (see all proteins):
    HSF1    HSF4

    HSF2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HSF2
    PGOHUM00000239466


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/573 NCBI SNPs in HSF2 are shown (see all 573    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs454964011,2
    C,--120296105(+) CCTTAC/TCACCT 3 -- us2k15Minor allele frequency- T:0.00NS 190
    rs454965931,2
    C,--120296405(+) CCTAGT/GTCATT 3 -- us2k15Minor allele frequency- G:0.00NS 188
    rs455116921,2
    C,--120297202(+) TTTTGA/TTAAAC 3 -- us2k15Minor allele frequency- T:0.01NS 152
    rs455711351,2
    C,F,--120297601(+) CTCTGT/CCGTGC 3 -- us2k16Minor allele frequency- C:0.02NS WA 306
    rs454611931,2
    C,--120297628(+) TGGCCA/TGGGAC 3 -- us2k15Minor allele frequency- T:0.01NS 190
    rs455085921,2
    F--120297677(+) CGGAGA/TCTTGT 3 -- ut515Minor allele frequency- T:0.01NS 190
    rs1137991041,2
    --120298414(+) GAGGCA/GATCTT 3 -- int11Minor allele frequency- G:0.00CSA 1
    rs769157681,2
    --120298878(+) ACAGTG/ACATGT 3 -- int11Minor allele frequency- A:0.01NA 120
    rs729564151,2
    C,--120298885(+) ATGTGC/GATTAG 3 -- int11Minor allele frequency- G:0.01NA 120
    rs759022811,2
    C,--120299213(+) TTTCCA/GACTTC 3 -- int10--------

    HapMap Linkage Disequilibrium report for HSF2 (122720691 - 122754264 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HSF2
         1 CNV: 3636

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HSF2 for disorders           About GeneDecksing

    OMIM gene information: 140581    OMIM disorders: --

    10 diseases for HSF2:    About MalaCards
    cleft lip/palate    cleft lip    paget's disease of bone    neurodegenerative disease
    varicocele    breast carcinoma    hypoxia    carcinoma
    leukemia    neuronitis

    4 Novoseek disease relationships for HSF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 78.6 133 11585899 (6), 17213196 (4), 12813038 (4), 8114740 (3) (see all 45)
    erythroleukemia 71.6 17 8114740 (1), 9738016 (1), 11557063 (1), 17213196 (1) (see all 10)
    neurodegenerative diseases 10.3 1 16048840 (1)
    breast cancer 0 1 9367858 (1)

    Human Genome Epidemiology (HuGE) Navigator: HSF2 (4 documents)

    Export disorders for HSF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSF2 gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with HSF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. (PubMed id 1871106)1, 2, 3, 9 Schuetz T.J.... Kingston R.E. (1991)
    2. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. (PubMed id 8339932)1, 2, 9 Sheldon L. and Kingston R.E. (1993)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. (PubMed id 19129477)1, 9 Sandqvist A....Sistonen L. (2009)
    6. MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation. (PubMed id 18211895)1, 9 Zhang J....Sarge K.D. (2008)
    7. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. (PubMed id 17213196)1, 9 Ostling P....Sistonen L. (2007)
    8. Identification of the PP2A-interacting region of heat shock transcription factor 2. (PubMed id 17688198)1, 9 Xing H....Sarge K.D. (2007)
    9. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. (PubMed id 12813038)1, 9 He H....Calderwood S.K. (2003)
    10. Novel testis-specific protein that interacts with heat shock factor 2. (PubMed id 9651507)1, 9 Yoshima T.... Yanagi H. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3298 HGNC: 5225 AceView: HSF2 Ensembl:ENSG00000025156 euGenes: HUgn3298
    ECgene: HSF2 H-InvDB: HSF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSF2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hsf2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSF2 gene:
    Search GeneIP for patents involving HSF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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