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Aliases for HSF1 Gene

Aliases for HSF1 Gene

  • Heat Shock Transcription Factor 1 2 3 4
  • HSTF 1 3 4
  • HSTF1 3 4
  • HSF 1 3 4
  • Heat Shock Factor Protein 1 3

External Ids for HSF1 Gene

Summaries for HSF1 Gene

Entrez Gene Summary for HSF1 Gene

  • The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSF1 Gene

HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and TGF-Beta Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is HSF2.

UniProtKB/Swiss-Prot for HSF1 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF1 Gene

Genomics for HSF1 Gene

Genomic Location for HSF1 Gene

Start:
144,291,588 bp from pter
End:
144,314,722 bp from pter
Size:
23,135 bases
Orientation:
Plus strand

Genomic View for HSF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF1 Gene

Proteins for HSF1 Gene

  • Protein details for HSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00613-HSF1_HUMAN
    Recommended name:
    Heat shock factor protein 1
    Protein Accession:
    Q00613
    Secondary Accessions:
    • A8K4L0
    • A8MW26
    • Q53XT4

    Protein attributes for HSF1 Gene

    Size:
    529 amino acids
    Molecular mass:
    57260 Da
    Quaternary structure:
    • Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the interaction prevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such as metal ions, HSF1 is released from the complex, homotrimerizes, is hyperphosphorylated and translocated to the nucleus where, subsequently, it can activate transcription. Binds the complex through the regulatory domain. Interacts with SYMPK and CSTF2 in heat-stressed cells. Interacts with FKBP4 in the HSP90 multichaperone complex; the interaction is independent of the phosphorylation state of HSF1. Interacts with MAPKAPK2. Interacts with EEF1D at heat shock promoter elements (HSE).

    Three dimensional structures from OCA and Proteopedia for HSF1 Gene

    Alternative splice isoforms for HSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF1 Gene

Proteomics data for HSF1 Gene at MOPED

Post-translational modifications for HSF1 Gene

  • Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation of transcription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures. Levels increase on specific residues heat-shock and enhance HSF1 transactivation activity. Phosphorylation on Ser-307 derepresses activation on heat-stress and in combination with Ser-303 phosphorylation appears to be involved in recovery after heat-stress. Phosphorylated on Ser-230 by CAMK2, in vitro. Cadmium also enhances phosphorylation at this site. Phosphorylation on Ser-303 is a prerequisite for HSF1 sumoylation. Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding. Phosphorylation on Thr-142 also mediates transcriptional activity induced by heat. Phosphorylation on Ser-326 plays an important role in heat activation of HSF1 transcriptional activity.
  • Sumoylated with SUMO1 and SUMO2 on heat-shock. Heat-inducible sumoylation occurs after 15 min of heat-shock, after which levels decrease and at 4 hours, levels return to control levels. Sumoylation has no effect on HSE binding nor on transcriptional activity. Phosphorylation on Ser-303 is a prerequisite for sumoylation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys62

Other Protein References for HSF1 Gene

No data available for DME Specific Peptides for HSF1 Gene

Domains for HSF1 Gene

UniProtKB/Swiss-Prot:

HSF1_HUMAN
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.:
    • Q00613
Family:
  • Belongs to the HSF family.:
    • Q00613
genes like me logo Genes that share domains with HSF1: view

No data available for Gene Families for HSF1 Gene

Function for HSF1 Gene

Molecular function for HSF1 Gene

GENATLAS Biochemistry: heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited through complex with HSP90
UniProtKB/Swiss-Prot Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Ontology (GO) - Molecular Function for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8926278
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 8926278
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with HSF1: view
genes like me logo Genes that share phenotypes with HSF1: view

Animal Models for HSF1 Gene

MGI Knock Outs for HSF1:

miRNA for HSF1 Gene

miRTarBase miRNAs that target HSF1
Targeting motifs for HSF1 Gene
HOMER Transcription Factor Regulatory Elements motif HSF1
  • Consensus sequence: NNTTCTGGAANNTTCTAGAA Submotif: canonical Cell Type: HepG2 GeoId: GSE31477

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for HSF1 Gene

Localization for HSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF1 Gene COMPARTMENTS Subcellular localization image for HSF1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with HSF1: view

Pathways for HSF1 Gene

genes like me logo Genes that share pathways with HSF1: view

Pathways by source for HSF1 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for HSF1 Gene
3 Qiagen pathways for HSF1 Gene
1 Cell Signaling Technology pathway for HSF1 Gene
1 KEGG pathway for HSF1 Gene

Gene Ontology (GO) - Biological Process for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8926278
GO:0001701 in utero embryonic development --
GO:0001892 embryonic placenta development IEA --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with HSF1: view

Compounds for HSF1 Gene

(70) Novoseek inferred chemical compound relationships for HSF1 Gene

Compound -log(P) Hits PubMed IDs
geldanamycin 68.2 19
l-azetidine 2-carboxylic acid 66.9 1
mg 132 62.4 16
sodium arsenite 61.3 5
radicicol 49.2 1
genes like me logo Genes that share compounds with HSF1: view

Transcripts for HSF1 Gene

Unigene Clusters for HSF1 Gene

Heat shock transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7:
SP8: -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: - -
SP13: - -
SP14:
SP15: - - -

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for HSF1 Gene

GeneLoc Exon Structure for
HSF1
ECgene alternative splicing isoforms for
HSF1

Expression for HSF1 Gene

mRNA expression in normal human tissues for HSF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSF1 Gene

SOURCE GeneReport for Unigene cluster for HSF1 Gene Hs.530227

genes like me logo Genes that share expressions with HSF1: view

Orthologs for HSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSF1 36
  • 89.48 (n)
  • 91.59 (a)
HSF1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSF1 36
  • 88.83 (n)
  • 92.19 (a)
HSF1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsf1 36
  • 87.52 (n)
  • 90.44 (a)
Hsf1 16
Hsf1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSF1 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF1 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsf1 36
  • 87.6 (n)
  • 90.65 (a)
chicken
(Gallus gallus)
Aves HSF1 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF1 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1051 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489822 36
  • 71.56 (n)
  • 70.67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3625 36
zebrafish
(Danio rerio)
Actinopterygii hsf1 36
  • 68.05 (n)
  • 64.66 (a)
hsf1 37
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hsf 37
  • 24 (a)
OneToMany
Hsf 38
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea hsf-1 37
  • 20 (a)
OneToMany
Y53C10A.12 38
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 37
  • 14 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9998 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2885 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 30 (a)
OneToMany
Species with no ortholog for HSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF1 Gene

ENSEMBL:
Gene Tree for HSF1 (if available)
TreeFam:
Gene Tree for HSF1 (if available)

Paralogs for HSF1 Gene

Paralogs for HSF1 Gene

Selected SIMAP similar genes for HSF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSF1: view

Variants for HSF1 Gene

Sequence variations from dbSNP and Humsavar for HSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3757975 -- 144,313,339(-) GGAGG(C/G)TCTGT intron-variant
rs3757976 -- 144,313,067(-) AGCCC(C/T)AGGCC intron-variant, downstream-variant-500B
rs3757977 -- 144,310,288(-) GTGGG(A/G)CAGCG intron-variant
rs4256628 -- 144,308,151(+) CAGCC(A/G)CCCCT intron-variant
rs4262358 -- 144,306,316(+) tccta(C/G)cttct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSF1 Gene

Variant ID Type Subtype PubMed ID
dgv7940n71 CNV Loss 21882294
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7957n71 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv8396 CNV Gain 18304495
dgv7960n71 CNV Loss 21882294
nsv891832 CNV Gain+Loss 21882294
nsv891838 CNV Gain 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv824804 CNV Gain 20364138
nsv891842 CNV Gain+Loss 21882294
nsv891843 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
esv2658902 CNV Deletion 23128226
dgv7962n71 CNV Loss 21882294
esv25318 CNV Gain 19812545
esv1341308 CNV Deletion 17803354

Relevant External Links for HSF1 Gene

HapMap Linkage Disequilibrium report
HSF1

Disorders for HSF1 Gene

(1) University of Copenhagen DISEASES for HSF1 Gene

(22) Novoseek inferred disease relationships for HSF1 Gene

Disease -log(P) Hits PubMed IDs
shock 90.6 281
erythroleukemia 48.7 3
neurodegenerative diseases 41.7 6
cancer 22.7 33
amyotrophic lateral sclerosis 19.4 2

Relevant External Links for HSF1

Genetic Association Database (GAD)
HSF1
genes like me logo Genes that share disorders with HSF1: view

No data available for UniProtKB/Swiss-Prot for HSF1 Gene

Publications for HSF1 Gene

  1. Molecular cloning and expression of a human heat shock factor, HSF1. (PMID: 1871105) Rabindran S.K. … Wu C. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 23
  2. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. (PMID: 11447121) Holmberg C.I. … Sistonen L. (EMBO J. 2001) 3 4 23
  3. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. (PMID: 12659875) Soncin F. … Calderwood S.K. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  4. Phosphorylation of serine 303 is a prerequisite for the stress- inducible SUMO modification of heat shock factor 1. (PMID: 12665592) Hietakangas V. … Sistonen L. (Mol. Cell. Biol. 2003) 3 4 23
  5. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PMID: 14707147) Xing H. … Sarge K.D. (J. Biol. Chem. 2004) 3 4 23

Products for HSF1 Gene

  • Addgene plasmids for HSF1

Sources for HSF1 Gene

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