External Ids for HSF1 Gene
Previous GeneCards Identifiers for HSF1 Gene
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSF1 Gene
HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include amyotrophic lateral sclerosis 1. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HSF2.
UniProtKB/Swiss-Prot for HSF1 Gene
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.