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HSF1 Gene

protein-coding   GIFtS: 68
GCID: GC08P145515

Heat Shock Transcription Factor 1

  See HSF1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Heat Shock Transcription Factor 11 2 3
HSTF12 3
HSF 12 3
HSTF 12 3
Heat Shock Factor Protein 12

External Ids:    HGNC: 52241   Entrez Gene: 32972   Ensembl: ENSG000001851227   OMIM: 1405805   UniProtKB: Q006133   

Export aliases for HSF1 gene to outside databases

Previous GC identifers: GC08P143129 GC08U900025 GC08P145120 GC08P145520 GC08P145486 GC08P140629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSF1 Gene:
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly
induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major
repressor of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSF1 Gene:
HSF1 (heat shock transcription factor 1) is a protein-coding gene. Diseases associated with HSF1 include spinocerebellar ataxia type 6, and amyotrophic lateral sclerosis. GO annotations related to this gene include RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HSF4.

UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613
Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates
transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

Gene Wiki entry for HSF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSF1 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSF1 promoter sequence
   Search Chromatin IP Primers for HSF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

HSF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSF1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145515:  view genomic region     (about GC identifiers)

Start:
145,515,270 bp from pter      End:
145,538,385 bp from pter
Size:
23,116 bases      Orientation:
plus strand

1 alternative location:
Chr8+,NW_003315924 60,847-83,981     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613 (See protein sequence)
Recommended Name: Heat shock factor protein 1  
Size: 529 amino acids; 57260 Da
Subunit: Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the
interaction prevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such
as metal ions, HSF1 is released from the complex, homotrimerizes, is hyperphosphorylated and translocated to the
nucleus where, subsequently, it can activate transcription. Binds the complex through the regulatory domain.
Interacts with SYMPK and CSTF2 in heat-stressed cells. Interacts with FKBP4 in the HSP90 multichaperone complex;
the interaction is independent of the phosphorylation state of HSF1. Interacts with MAPKAPK2. Interacts with
EEF1D at heat shock promoter elements (HSE)
1 PDB 3D structure from and Proteopedia for HSF1:
2LDU (3D)    
Secondary accessions: A8K4L0 A8MW26 Q53XT4
Alternative splicing: 2 isoforms:  Q00613-1   Q00613-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HSF1: NX_Q00613

Explore proteomics data for HSF1 at MOPED

Post-translational modifications: 

  • Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation of
    transcription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures.
    Levels increase on specific residues heat-shock and enhance HSF1 transactivation activity. Phosphorylation on
    Ser-307 derepresses activation on heat-stress and in combination with Ser-303 phosphorylation appears to be
    involved in recovery after heat-stress. Phosphorylated on Ser-230 by CAMK2, in vitro. Cadmium also enhances
    phosphorylation at this site. Phosphorylation on Ser-303 is a prerequisite for HSF1 sumoylation. Phosphorylation
    on Ser-121 inhibits transactivation and promotes HSP90 binding. Phosphorylation on Thr-142 also mediates
    transcriptional activity induced by heat1
  • Sumoylated with SUMO1 and SUMO2 on heat-shock. Heat-inducible sumoylation occurs after 15 min of heat-shock, after
    which levels decrease and at 4 hours, levels return to control levels. Sumoylation has no effect on HSE binding
    nor on transcriptional activity. Phosphorylation on Ser-303 is a prerequisite for sumoylation1
  • Ubiquitination2 at Lys62
  • Modification sites at PhosphoSitePlus

  • See HSF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005517.1  
    ENSEMBL proteins: 
     ENSP00000431512   ENSP00000436616   ENSP00000383590  
    Reactome Protein details: Q00613

    HSF1 Human Recombinant Protein Products:

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    Novus Biologicals HSF1 Proteins
    Novus Biologicals HSF1 Lysate
    Sino Biological Recombinant Protein for HSF1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HSF1
    Cloud-Clone Corp. Proteins for HSF1

     
    Search eBioscience for Proteins for HSF1 

     
    antibodies-online proteins for HSF1 (16 products) 

     
    antibodies-online peptides for HSF1

    HSF1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HSF1
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    antibodies-online antibodies for HSF1 (332 products) 

    HSF1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HSF1
    Cloud-Clone Corp. CLIAs for HSF1
    Search eBioscience for ELISAs for HSF1 
    antibodies-online kits for HSF1 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR027725 HSF_fam
     IPR027072 HSF1
     IPR011991 WHTH_DNA-bd_dom
     IPR000232 HSF_DNA-bd
     IPR010542 Vert_HSTF_C

    Graphical View of Domain Structure for InterPro Entry Q00613

    ProtoNet protein and cluster: Q00613

    2 Blocks protein domains:
    IPB000232 Heat shock factor (HSF)-type DNA-binding domain
    IPB010542 Vertebrate heat shock transcription factor


    UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the HSF family


    Find genes that share domains with HSF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSF1_HUMAN, Q00613
    Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates
    transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked

         Genatlas biochemistry entry for HSF1:
    heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited through
    complex with HSP90

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA10561509
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11005381
         
    Find genes that share ontologies with HSF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HSF1:
     Decreased Hepatitis C virus re 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hsf1):
     cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     immune system  integument  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system  vision/eye 

    Find genes that share phenotypes with HSF1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HSF1: Hsf1tm1Anak Hsf1tm1Ijb Hsf1tm1Miv

       genOway: Develop your customized and physiologically relevant rodent model for HSF1

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  NNTTCTGGAANNTTCTAGAA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSF1:
    hsa-mir-26b-5p (MIRT029982)

    Block miRNA regulation of human, mouse, rat HSF1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate HSF1:
    hsa-miR-214* hsa-miR-548c-3p hsa-miR-455-3p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidHSF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSF1
    Predesigned siRNA for gene silencing in human, mouse, rat HSF1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSF1

    Clone
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    OriGene ORF clones in mouse, rat for HSF1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSF1 (NM_005526)
    Sino Biological Human cDNA Clone for HSF1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSF1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF1
    Addgene plasmids for HSF1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSF1_HUMAN, Q00613: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to
    nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043234protein complex IEA--
    GO:0045120pronucleus IEA--

    Find genes that share ontologies with HSF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSF1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1ERK Signaling
    MAPK Signaling0.58
    2TGF-Beta Pathway
    JNK Pathway0.51
    3Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions0.36
    4Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33
    5MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31


    Find genes that share SuperPaths with HSF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HSF1
        MAPK Signaling
    Epithelial Tight Junctions
    JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for HSF1
        MAP Kinase Signaling

    2 GeneGo (Thomson Reuters) Pathways for HSF1
        Proteolysis Putative SUMO-1 pathway
    Cytoskeleton remodeling RalA regulation pathway


    4 Reactome Pathways for HSF1
        Regulation of HSF1-mediated heat shock response
    HSF1-dependent transactivation
    HSF1 activation
    Attenuation phase


    1 Kegg Pathway  (Kegg details for HSF1):
        Legionellosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSF1: 
              Transcription Factors in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HSF1

    Selected Interacting proteins for HSF1 (Q006131, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 74)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    ENSG00000232804P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ----
    GO:0001892embryonic placenta development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006468protein phosphorylation IEA--

    Find genes that share ontologies with HSF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSF1

    Selected Novoseek inferred chemical compound relationships for HSF1 gene (see all 70)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    geldanamycin 68.2 21 10632574 (5), 19935870 (4), 9727490 (2), 18852129 (2) (see all 10)
    l-azetidine 2-carboxylic acid 66.9 2 8441385 (1)
    mg 132 62.4 29 19006120 (4), 10529368 (3), 9920768 (3), 11426935 (2) (see all 8)
    sodium arsenite 61.3 6 10600494 (2), 7930803 (1), 14673132 (1), 19358893 (1)
    radicicol 49.2 1 16173045 (1)
    cyclopentenone 49.1 4 8943275 (1), 12815164 (1), 12707336 (1)
    ukrain 45.4 5 14703944 (4)
    arsenite 43.9 10 15618017 (2), 9551088 (2), 16447264 (2), 15978632 (1)
    geranylgeranylacetone 42.5 2 17182004 (2)
    diamide 40.6 10 11851405 (4), 12796815 (1)



    Find genes that share compounds with HSF1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSF1 gene: 
    NM_005526.2  

    Unigene Cluster for HSF1:

    Heat shock transcription factor 1
    Hs.530227  [show with all ESTs]
    Unigene Representative Sequence: BC014638
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528838(uc003zbt.4 uc003zbu.4) ENST00000528988 ENST00000533240
    ENST00000400780 ENST00000532338 ENST00000528199 ENST00000529630 ENST00000534314
    ENST00000527328 ENST00000531447 ENST00000533130 ENST00000530661 ENST00000528842

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    hsa-miR-214* hsa-miR-548c-3p hsa-miR-455-3p hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidHSF1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HSF1 (NM_005526)
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      QuantiTect SYBR Green Assays in human, mouse, rat HSF1
      QuantiFast Probe-based Assays in human, mouse, rat HSF1

    Additional mRNA sequence: 

    AF299094.1 AK222497.1 AK290975.1 AK300205.1 BC014638.1 BT007351.1 M64673.1 

    Selected DOTS entries (see all 28):

    DT.102822038  DT.454101  DT.100804997  DT.100804984  DT.100743927  DT.40291106  DT.100804993  DT.102826547 
    DT.100804983  DT.121492231  DT.411156  DT.92326525  DT.121492097  DT.100804985  DT.121492223  DT.95352123 
    DT.100804986  DT.100804989  DT.100804995  DT.100804998  DT.121492132  DT.121492140  DT.121492168  DT.92451076 

    Selected AceView cDNA sequences (see all 378):

    BF591334 BM450284 CR623211 AW673647 AK125467 CR613149 BM837139 BF726102 
    BM913488 BM682048 AI439026 AI651222 BC014638 CK904568 CA426438 BM915611 
    AU125983 BM844354 T28942 BF448927 BU174079 AK126580 AU076486 BM982366 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 (see all 15)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a ·
    SP1:              -     -     -                 -     -                             -     -                                   -                             -   
    SP2:                                                                                                                          -                             -   
    SP3:                                                                                                                          -                             -   
    SP4:                                                                                                                                                        -   
    SP5:                                                                                                                                                        -   

    ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c · 19d
    SP1:  -                 -                                 
    SP2:  -                 -                                 
    SP3:  -                                                   
    SP4:                    -                                 
    SP5:  -                 -           -                     


    ECgene alternative splicing isoforms for HSF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HSF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTGCCTG
    HSF1 Expression
    About this image

    HSF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530227
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HSF1: 
              Transcription Factors in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Heat Shock Proteins & Chaperones in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSF1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsf11 , 5 heat shock factor 11, 5 87.52(n)1
    90.44(a)1
      15 (35.95 cM)5
    154991  NM_008296.21  NP_032322.11 
     764774455 
    chicken
    (Gallus gallus)
    Aves HSF16
    heat shock transcription factor 1
    87(a)
    1 ↔ 1
    AADN03017958.1(2586-5968)
    lizard
    (Anolis carolinensis)
    Reptilia HSF16
    heat shock transcription factor 1
    70(a)
    1 ↔ 1
    GL343752.1(38867-107395)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10512 Xenopus laevis heat shock factor 1 (XHSF1) mRNA, complete more 77.68(n)    L36924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsf12 heat shock transcription factor 1 79.04(n)   58123  AB062117.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hsf3 response to heat DNA binding 56(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C10A.123 HSF-type DNA-binding domain 32(a)   I(11961851-11970016)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HSF16
    Trimeric heat shock transcription factor, activate...
    14(a)
    1 → many
    VII(368753-371254) YGL073W
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.99982 Vitis vinifera transcribed sequence with weak similarity more 77.72(n)    CD009302.1 
    rice
    (Oryza sativa)
    Liliopsida AK109856.12   -- 76.67(n)    AK109856.1 


    ENSEMBL Gene Tree for HSF1 (if available)
    TreeFam Gene Tree for HSF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSF1 gene
    HSF42  HSF22  
    2 SIMAP similar genes for HSF1 using alignment to 3 protein entries:     HSF1_HUMAN (see all proteins):
    HSF2    HSF4

    Find genes that share paralogs with HSF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSF1 (see all 526)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134919941,2
    F--145517130(+) TTCTTC/TTTTTT 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1480053041,2
    --145517222(+) GGTTCA/CAGCAA 1 -- int10--------
    rs1898504581,2
    --145517367(+) CACCCA/GCCTTG 1 -- int10--------
    rs1832332431,2
    --145517483(+) TGGGGA/GAGGGG 1 -- int10--------
    rs45702031,2
    C,F,A--145517495(+) ATCCGC/AGATTA 1 -- int15Minor allele frequency- A:0.50NA WA CSA 128
    rs1864766351,2
    --145517603(+) GGCCCA/GGTGTA 1 -- int10--------
    rs1905160011,2
    --145517624(+) GGACCA/GAGGCA 1 -- int10--------
    rs1837777661,2
    --145517787(+) CAGTAA/TGAAGT 1 -- int10--------
    rs49772041,2
    C,F,A--145517883(+) CTCCAA/GGCCGC 1 -- int15Minor allele frequency- G:0.49NA WA CSA 128
    rs1417071781,2
    --145518095(+) TCTCTA/GCTGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSF1 (145515270 - 145538385 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HSF1 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658902CNV Deletion23128226
    esv1341308CNV Deletion17803354
    dgv7962n71CNV Loss21882294
    nsv891841CNV Loss21882294
    dgv7960n71CNV Loss21882294
    nsv891846CNV Loss21882294
    dgv7955n71CNV Loss21882294
    nsv891817CNV Loss21882294
    dgv7957n71CNV Loss21882294
    nsv891807CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSF1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 140580    OMIM disorders: --

    2 diseases for HSF1:    
    About MalaCards
    spinocerebellar ataxia type 6    amyotrophic lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for HSF1:
    Huntington's disease

    Find genes that share disorders with HSF1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HSF1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 90.6 828 8904320 (12), 15364926 (6), 9501096 (5), 10632574 (5) (see all 99)
    erythroleukemia 48.7 3 8114740 (1), 17213196 (1), 9374530 (1)
    neurodegenerative diseases 41.7 7 10407188 (1), 16048840 (1), 18257221 (1), 20166962 (1) (see all 6)
    cancer 22.7 41 17884799 (5), 16885369 (3), 19820069 (3), 17889646 (2) (see all 20)
    amyotrophic lateral sclerosis 19.4 3 16950627 (1), 17688194 (1)
    glioblastoma 12.9 2 11747550 (1), 12740661 (1)
    prostate carcinoma 7.17 2 10702402 (1), 15152009 (1)
    inflammation 4.8 9 12815164 (2), 15649840 (1), 16061216 (1), 8759754 (1) (see all 6)
    colon cancer 1.6 7 19179333 (2), 15457556 (2), 17884799 (1), 18546582 (1)
    cardiovascular diseases 0 2 18257221 (1), 16678833 (1)

    Genetic Association Database (GAD): HSF1

    Export disorders for HSF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSF1 gene, integrated from 10 sources (see all 478):
    (articles sorted by number of sources associating them with HSF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a human heat shock factor, HSF1. (PubMed id 1871105)1, 2, 3, 9 Rabindran S.K.... Wu C. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    2. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. (PubMed id 12659875)1, 2, 9 Soncin F.... Calderwood S.K. (Biochem. Biophys. Res. Commun. 2003)
    3. Phosphorylation of serine 303 is a prerequisite for the stress- inducible SUMO modification of heat shock factor 1. (PubMed id 12665592)1, 2, 9 Hietakangas V....Sistonen L. (Mol. Cell. Biol. 2003)
    4. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. (PubMed id 11447121)1, 2, 9 Holmberg C.I.... Sistonen L. (EMBO J. 2001)
    5. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PubMed id 14707147)1, 2, 9 Xing H.... Sarge K.D. (J. Biol. Chem. 2004)
    6. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. (PubMed id 16278218)1, 2 Wang X....Calderwood S.K. (J. Biol. Chem. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. (PubMed id 11583998)1, 2 Guo Y.... Voellmy R. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3297 HGNC: 5224 AceView: HSF1 Ensembl:ENSG00000185122 euGenes: HUgn3297
    ECgene: HSF1 Kegg: 3297 H-InvDB: HSF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSF1 gene:
    Search GeneIP for patents involving HSF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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