HSF1 Gene
protein-coding GIFtS: 63
GCID: GC08P145515
|
|
heat shock transcription factor 1
| |
Aliases
for HSF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Heat Shock Transcription Factor 11 2 3 | | HSTF11 2 3 | | HSF 12 3 | | HSTF 12 3 | | Heat Shock Factor Protein 12 |
Export aliases for HSF1 gene to outside databasesPrevious GC identifers: GC08P143129 GC08U900025 GC08P145120 GC08P145520 GC08P145486 GC08P140629 |
Summaries
for HSF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HSF1:
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly inducedafter temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor ofthis gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked
Gene Wiki entry for HSF1
|
Genomic Views
for HSF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HSF1 gene promoter:
AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for HSF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3HSF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145515: view genomic region
(about GC identifiers)
Start:
|
145,515,270 bp from pter |
End:
|
145,538,385 bp from pter |
Size:
|
23,116 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr8+,PATCHES 145,431,731-145,454,865 |
|
Proteins
for HSF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613 (See
protein sequence)Recommended Name: Heat shock factor protein 1 Size: 529 amino acids; 57260 Da
Subunit: Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the interactionprevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such as metal ions,HSF1 is released from the complex, homotrimerizes, is hyperphosphorylated and translocated to the nucleus where,subsequently, it can activate transcription. Binds the complex through the regulatory domain. Interacts with SYMPK andCSTF2 in heat-stressed cells. Interacts with FKBP4 in the HSP90 multichaperone complex; the interaction is independentof the phosphorylation state of HSF1. Interacts with MAPKAPK2. Interacts with EEF1D at heat shock promoter elements(HSE)
Subcellular location: Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclearstress granules. Colocalizes with SUMO1 in nuclear stress granules
1 PDB 3D structure from  and Proteopedia  for HSF1:2LDU (3D)
Secondary accessions: A8K4L0 A8MW26 Q53XT4Alternative splicing: 2 isoforms: Q00613-1 Q00613-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HSF1: NX_Q00613
Post-translational modifications:
Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation oftranscription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures.Levels increase on specific residues heat-shock and enhance HSF1 transactivation activity. Phosphorylation on Ser-307derepresses activation on heat-stress and in combination with Ser-303 phosphorylation appears to be involved inrecovery after heat-stress. Phosphorylated on Ser-230 by CAMK2, in vitro. Cadmium also enhances phosphorylation atthis site. Phosphorylation on Ser-303 is a prerequisite for HSF1 sumoylation. Phosphorylation on Ser-121 inhibitstransactivation and promotes HSP90 binding. Phosphorylation on Thr-142 also mediates transcriptional activity inducedby heat1
Sumoylated with SUMO1 and SUMO2 on heat-shock. Heat-inducible sumoylation occurs after 15 min of heat-shock, afterwhich levels decrease and at 4 hours, levels return to control levels. Sumoylation has no effect on HSE binding nor ontranscriptional activity. Phosphorylation on Ser-303 is a prerequisite for sumoylation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q00613
HSF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005517.1
ENSEMBL proteins: ENSP00000431512 ENSP00000436616 ENSP00000383590
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
HSF1 for ontologies About GeneDecksing
HSF1 Antibody Products:
Assay Products for HSF1: |
Protein
Domains /
Families
for HSF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSF1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q00613ProtoNet protein and cluster: Q00613 2 Blocks protein families: IPB000232 Heat shock factor (HSF)-type DNA-binding domain IPB010542 Vertebrate heat shock transcription factor
UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcriptionfactorsSimilarity: Belongs to the HSF family |
Function
for HSF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HSF1_HUMAN, Q00613Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription.In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked Genatlas biochemistry entry for HSF1:heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited throughcomplex with HSP90
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSF1 (NM_005526) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
HSF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HSF1:
Animal Models:
Mouse knock-outs for HSF1: Hsf1tm1Miv Hsf1tm1Anak Hsf1tm1Ijb
12 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Hsf1):
HSF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HSF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Proteolysis Putative SUMO-1 pathway | | | 2 | Cytoskeleton remodeling_RalB regulation pathway | | | 3 | MAP Kinase Signaling | | | 4 | Rho Family GTPases | | | 5 | TGF-Beta Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for HSF1
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HSF1
1 
Cell Signaling Technology (CST) Pathway for HSF1
2  GeneGo (Thomson Reuters) Pathways for HSF1
HSF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HSF1
5/64 Interacting proteins for HSF1 (Q006131, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 64)About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001701 | in utero embryonic development |
-- | -- | | GO:0001892 | embryonic placenta development |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006468 | protein phosphorylation |
IEA | -- |
HSF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HSF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HSF1 for compounds About GeneDecksing
 Browse Tocris compounds for HSF1
10/70 Novoseek chemical compound relationships for HSF1 gene (see all 70) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| geldanamycin |
68.2 |
21 |
10632574 (5), 19935870 (4), 9727490 (2), 18852129 (2) (see all 10) |
| l-azetidine 2-carboxylic acid |
66.9 |
2 |
8441385 (1) |
| mg 132 |
62.4 |
29 |
19006120 (4), 10529368 (3), 9920768 (3), 11426935 (2) (see all 8) |
| sodium arsenite |
61.3 |
6 |
10600494 (2), 7930803 (1), 14673132 (1), 19358893 (1) |
| radicicol |
49.2 |
1 |
16173045 (1) |
| cyclopentenone |
49.1 |
4 |
8943275 (1), 12815164 (1), 12707336 (1) |
| ukrain |
45.4 |
5 |
14703944 (4) |
| arsenite |
43.9 |
10 |
15618017 (2), 9551088 (2), 16447264 (2), 15978632 (1) |
| geranylgeranylacetone |
42.5 |
2 |
17182004 (2) |
| diamide |
40.6 |
10 |
11851405 (4), 12796815 (1) |
Search CenterWatch for drugs/clinical trials and news about HSF1
|
Transcripts
for HSF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HSF1 gene: NM_005526.2 Unigene Cluster for HSF1: Heat shock transcription factor 1 Hs.530227 [show with all ESTs]Unigene Representative Sequence: BC01463814 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528838(uc003zbt.4 uc003zbu.4) ENST00000528988 ENST00000533240
ENST00000400780 ENST00000532338 ENST00000528199 ENST00000529630 ENST00000534314
ENST00000527328 ENST00000531447 ENST00000533130 ENST00000530661 ENST00000530770
ENST00000528842
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HSF1 (NM_005526) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF1 |
Additional cDNA sequence: AF299094.1 AK222497.1 AK290975.1 AK300205.1 BC014638.1 BT007351.1 M64673.1 24/28 DOTS entries (see all 28): DT.102822038 DT.454101 DT.100804997 DT.100804984 DT.100743927 DT.40291106 DT.100804993 DT.102826547 DT.100804983 DT.121492231 DT.411156 DT.92326525 DT.121492097 DT.100804985 DT.121492223 DT.95352123 DT.100804986 DT.100804989 DT.100804995 DT.100804998 DT.121492132 DT.121492140 DT.121492168 DT.92451076 24/378 AceView cDNA sequences (see all 378): AI651222 BE791171 AI440385 AI439026 BM913488 CD370653 BM916383 BM699799 BM561170 CD244586 CA306275 CA311824 T08623 NM_005526 CA397549 BM915611 BU517119 BU161300 BM557801 BF591334 BM982366 BF058566 AW007349 AF299094
GeneLoc Exon Structure
5/15 Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 (see all 15) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15a | · |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | - | | - | | | | | | | | | | | | - | | | | | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | |
| ExUns: | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · | 19b | · | 19c | · | 19d |
|---|
|
| SP1: | - | | | | | | - | | | | | | | | | | | | |
| SP2: | - | | | | | | - | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | |
| SP5: | - | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for HSF1
|
Expression
for HSF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCTGCCTG
About this image
See HSF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSF1
SOURCE GeneReport for Unigene cluster: Hs.530227
SABiosciences Expression via Pathway-Focused PCR Arrays including HSF1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSF1 |
Orthologs
for HSF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HSF1 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Hsf11 , 5 |
heat shock factor 11, 5 |
87.52(n)1
90.44(a)1 |
|
15 (35.95 cM)5
154991 NM_008296.21 NP_032322.11
764774455 |
chicken
(Gallus gallus) |
Aves |
HSF16 |
-- |
78(a) |
1 ↔ 1 |
Un(60105089-60108399) |
lizard
(Anolis carolinensis) |
Reptilia |
HSF16 |
-- |
62(a) |
1 ↔ 1 |
GL343752.1(38867-107147) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.10512 |
Xenopus laevis heat shock factor 1 (XHSF1) mRNA, complete more |
77.68(n) |
|
L36924.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hsf12 |
heat shock transcription factor 1 |
79.04(n) |
|
58123 AB062117.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Hsf3 |
response to heat DNA binding |
56(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
Y53C10A.123 |
HSF-type DNA-binding domain |
32(a) |
|
I(11961851-11970016) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT-HSFA36AT-HSFA7A6(see all 21) |
heat stress transcription factor A-7a(see all 21) |
9(a)22(a)(see all 21) |
many ↔ manymany ↔ many(see all 21) |
5(971786-973683) 3(19265294-19266619) |
rice
(Oryza sativa) |
Liliopsida |
AK109856.12 |
-- |
76.67(n) |
|
AK109856.1 |
ENSEMBL Gene Tree for HSF1 (if available)
TreeFam Gene Tree for HSF1 (if available) |
Paralogs
for HSF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HSF1 gene
- HSF42 HSF22
2 SIMAP similar genes for HSF1 using alignment to 3 protein entries: HSF1_HUMAN (see all proteins):HSF2 HSF4
HSF1 for paralogs About GeneDecksing
|
Genomic Variants
for HSF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HSF1 (145515270 - 145538385 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HSF1
3 CNVs: 3752 31457 30306
1 Indel: 70488 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSF1 |
|
Disorders
/ Diseases
for HSF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSF1 for disorders About GeneDecksing
OMIM gene information: 140580
OMIM disorders: --
20/38  diseases for HSF1 (see all 38): About MalaCardsspinocerebellar ataxia type 6 amyotrophic lateral sclerosis pre-eclampsia spinocerebellar ataxia
lateral sclerosis oral squamous cell carcinoma squamous cell carcinoma neurodegenerative disease
mumps eclampsia cervical carcinoma carcinoma
alzheimer's disease cervicitis rheumatoid arthritis colon cancer
ataxia huntington's disease prostate carcinoma breast carcinoma
10/22 Novoseek disease relationships for HSF1 gene (see all 22) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| shock |
90.6 |
828 |
8904320 (12), 15364926 (6), 9501096 (5), 10632574 (5) (see all 99) |
| erythroleukemia |
48.7 |
3 |
8114740 (1), 17213196 (1), 9374530 (1) |
| neurodegenerative diseases |
41.7 |
7 |
10407188 (1), 16048840 (1), 18257221 (1), 20166962 (1) (see all 6) |
| cancer |
22.7 |
41 |
17884799 (5), 16885369 (3), 19820069 (3), 17889646 (2) (see all 20) |
| amyotrophic lateral sclerosis |
19.4 |
3 |
16950627 (1), 17688194 (1) |
| glioblastoma |
12.9 |
2 |
11747550 (1), 12740661 (1) |
| prostate carcinoma |
7.17 |
2 |
10702402 (1), 15152009 (1) |
| inflammation |
4.8 |
9 |
12815164 (2), 15649840 (1), 16061216 (1), 8759754 (1) (see all 6) |
| colon cancer |
1.6 |
7 |
19179333 (2), 15457556 (2), 17884799 (1), 18546582 (1) |
| cardiovascular diseases |
0 |
2 |
18257221 (1), 16678833 (1) |
Genetic Association Database (GAD): HSF1
Export disorders for HSF1 gene to outside databases
|
Publications
for HSF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSF1 gene, integrated from 9 sources (see all 445):
(articles sorted by number of sources associating them with HSF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and expression of a human heat shock factor, HSF1. (PubMed id 1871105)1, 2, 3, 9 Rabindran S.K.... Wu C. (1991)
- Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. (PubMed id 12659875)1, 2, 9 Soncin F.... Calderwood S.K. (2003)
- Phosphorylation of serine 303 is a prerequisite for the stress- inducible SUMO modification of heat shock factor 1. (PubMed id 12665592)1, 2, 9 Hietakangas V....Sistonen L. (2003)
- Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. (PubMed id 11447121)1, 2, 9 Holmberg C.I.... Sistonen L. (2001)
- HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PubMed id 14707147)1, 2, 9 Xing H.... Sarge K.D. (2004)
- Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. (PubMed id 16278218)1, 2 Wang X....Calderwood S.K. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. (PubMed id 11583998)1, 2 Guo Y.... Voellmy R. (2001)
|
External Searches for HSF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing HSF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing HSF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for HSF1 gene:
Search GeneIP for patents involving HSF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HSF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for HSF1 | | OriGene shRNA RFP for HSF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSF1 | | | OriGene Protein Over-expression Lysate for HSF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HSF1 | | OriGene 3'-UTR Clone for HSF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HSF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for HSF1 |
| |  |  |  |  | | | | | | Recombinant Protein for HSF1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSF1 |
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