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Aliases for HSF1 Gene

Aliases for HSF1 Gene

  • Heat Shock Transcription Factor 1 2 3 4 5
  • HSTF1 3 4
  • Heat Shock Factor Protein 1 3
  • HSTF 1 4
  • HSF 1 4

External Ids for HSF1 Gene

Previous GeneCards Identifiers for HSF1 Gene

  • GC08P143129
  • GC08U900025
  • GC08P145120
  • GC08P145520
  • GC08P145486
  • GC08P145515
  • GC08P140629

Summaries for HSF1 Gene

Entrez Gene Summary for HSF1 Gene

  • The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

GeneCards Summary for HSF1 Gene

HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Synucleinopathy and Amyotrophic Lateral Sclerosis 1. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cellular Senescence (REACTOME). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HSF4.

UniProtKB/Swiss-Prot for HSF1 Gene

  • Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5-NGAAN-3 pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).

  • (Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300.

Gene Wiki entry for HSF1 Gene

Additional gene information for HSF1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF1 Gene

Genomics for HSF1 Gene

Regulatory Elements for HSF1 Gene

Enhancers for HSF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H144101 1.2 ENCODE 21.7 -187.7 -187677 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF623 ZNF7 ZNF16 ZNF251 ZNF250 ZNF517 CPSF1 VPS28 ZNF696 LRRC14
GH08H144899 1.5 FANTOM5 ENCODE 13.5 +610.0 610032 3 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF7 CPSF1 ZNF16 ZNF251 VPS28 SHARPIN RPL8 ZNF250 SLC52A2 LRRC14
GH08H144322 1.4 ENCODE dbSUPER 13.8 +33.4 33448 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 SHARPIN BOP1 CPSF1 HSF1 ZNF7 ZNF707 ZNF16 DGAT1 KIFC2 MIR6848
GH08H144506 1.4 ENCODE dbSUPER 13.6 +217.4 217382 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 ZNF7 ZNF250 CPSF1 ZNF251 VPS28 LRRC14 ZNF623 ENSG00000254533 ZNF517 ZNF34
GH08H144353 1.3 Ensembl ENCODE 13.7 +64.9 64925 6 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ETS1 GLIS2 ELK1 ZNF143 ZNF207 CPSF1 VPS28 ZNF7 ZNF250 SHARPIN ZNF623 ZNF251 HSF1 ZNF34 ZNF707
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSF1 on UCSC Golden Path with GeneCards custom track

Promoters for HSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000232226 112 2201 PKNOX1 ATF1 ARNT ARID4B SIN3A YY1 GATA2 ELK1 ZNF143 ATF7

Genomic Location for HSF1 Gene

Chromosome:
8
Start:
144,291,588 bp from pter
End:
144,314,722 bp from pter
Size:
23,135 bases
Orientation:
Plus strand

Genomic View for HSF1 Gene

Genes around HSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF1 Gene

Proteins for HSF1 Gene

  • Protein details for HSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00613-HSF1_HUMAN
    Recommended name:
    Heat shock factor protein 1
    Protein Accession:
    Q00613
    Secondary Accessions:
    • A8K4L0
    • A8MW26
    • Q53XT4

    Protein attributes for HSF1 Gene

    Size:
    529 amino acids
    Molecular mass:
    57260 Da
    Quaternary structure:
    • Monomer; cytoplasmic latent and transcriptionally inactive monomeric form in unstressed cells (PubMed:8455624, PubMed:7935376, PubMed:7935471, PubMed:7623826, PubMed:9222587, PubMed:9727490, PubMed:11583998). Homotrimer; in response to stress, such as heat shock, homotrimerizes and translocates into the nucleus, binds to heat shock element (HSE) sequences in promoter of heat shock protein (HSP) genes and acquires transcriptional ability (PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:9222587, PubMed:9727490, PubMed:11583998, PubMed:26754925, PubMed:26727489). Interacts (via monomeric form) with FKBP4; this interaction occurs in unstressed cells (PubMed:11583998). Associates (via monomeric form) with HSP90 proteins in a multichaperone complex in unnstressed cell; this association maintains HSF1 in a non-DNA-binding and transcriptional inactive form by preventing HSF1 homotrimerization (PubMed:9727490, PubMed:11583998, PubMed:15661742, PubMed:16278218). Homotrimeric transactivation activity is modulated by protein-protein interactions and post-translational modifications (PubMed:11583998, PubMed:15016915, PubMed:16554823, PubMed:26754925). Interacts with HSP90AA1; this interaction is decreased in a IER5-dependent manner, promoting HSF1 accumulation in the nucleus, homotrimerization and DNA-binding activities (PubMed:26754925). Part (via regulatory domain in the homotrimeric form) of a large heat shock-induced HSP90-dependent multichaperone complex at least composed of FKBP4, FKBP5, HSP90 proteins, PPID, PPP5C and PTGES3; this association maintains the HSF1 homotrimeric DNA-bound form in a transcriptionally inactive form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Interacts with BAG3 (via BAG domain); this interaction occurs in normal and heat-shocked cells promoting nuclear shuttling of HSF1 in a BAG3-dependent manner (PubMed:26159920). Interacts (via homotrimeric and hyperphosphorylated form) with FKBP4; this interaction occurs upon heat shock in a HSP90-dependent multichaperone complex (PubMed:11583998). Interacts (via homotrimeric form preferentially) with EEF1A proteins (PubMed:15016915). In heat shocked cells, stress-denatured proteins compete with HSF1 homotrimeric DNA-bound form for association of the HSP90-dependent multichaperone complex, and hence alleviating repression of HSF1-mediated transcriptional activity (PubMed:11583998). Interacts (via homotrimeric form preferentially) with DAXX; this interaction relieves homotrimeric HSF1 from repression of its transcriptional activity by HSP90-dependent multichaperone complex upon heat shock (PubMed:15016915). Interacts (via D domain and preferentially with hyperphosphorylated form) with JNK1; this interaction occurs under both normal growth conditions and immediately upon heat shock (PubMed:10747973). Interacts (via D domain and preferentially with hyperphosphorylated form) with MAPK3; this interaction occurs upon heat shock (PubMed:10747973). Interacts with IER5 (via central region); this interaction promotes PPP2CA-induced dephosphorylation on Ser-121, Ser-307, Ser-314, Thr-323 and Thr-367 and HSF1 transactivation activity (PubMed:25816751, PubMed:26496226, PubMed:26754925). Found in a ribonucleoprotein complex composed of the HSF1 homotrimeric form, translation elongation factor eEF1A proteins and non-coding RNA heat shock RNA-1 (HSR1); this complex occurs upon heat shock and stimulates HSF1 DNA-binding activity (PubMed:16554823). Interacts (via transactivation domain) with HSPA1A/HSP70 and DNAJB1; these interactions result in the inhibition of heat shock- and HSF1-induced transcriptional activity during the attenuation and recovery phase from heat shock (PubMed:7935376, PubMed:9222587, PubMed:9499401). Interacts (via Ser-303 and Ser-307 phosphorylated form) with YWHAE; this interaction promotes HSF1 sequestration in the cytoplasm in an ERK-dependent manner (PubMed:12917326). Found in a complex with IER5 and PPP2CA (PubMed:26754925). Interacts with TPR; this interaction increases upon heat shock and stimulates export of HSP70 mRNA (PubMed:17897941). Interacts with SYMPK (via N-terminus) and CSTF2; these interactions occur upon heat shock (PubMed:14707147). Interacts (via transactivation domain) with HSPA8 (PubMed:9499401). Interacts with EEF1D; this interaction occurs at heat shock promoter element (HSE) sequences (PubMed:21597468). Interacts with MAPKAPK2 (PubMed:16278218). Interacts with PRKACA/PKA (PubMed:21085490). Interacts (via transactivation domain) with GTF2A2 (PubMed:11005381). Interacts (via transactivation domain) with GTF2B (PubMed:11005381). Interacts (via transactivation domain) with TBP (PubMed:11005381). Interacts with CDK9, CCNT1 and EP300 (PubMed:27189267). Interacts (via N-terminus) with XRCC5 (via N-terminus) and XRCC6 (via N-terminus); these interactions are direct and prevent XRCC5/XRCC6 heterodimeric binding and non-homologous end joining (NHEJ) repair activities induced by ionizing radiation (IR) (PubMed:26359349). Interacts with PLK1; this interaction occurs during the early mitotic period, increases upon heat shock but does not modulate neither HSF1 homotrimerization and DNA-binding activities (PubMed:15661742, PubMed:18794143). Interacts (via Ser-216 phosphorylated form) with CDC20; this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (PubMed:18794143). Interacts with MAD2L1; this interaction occurs in mitosis (PubMed:18794143). Interacts with BTRC; this interaction occurs during mitosis, induces its ubiquitin-dependent degradation following stimulus-dependent phosphorylation at Ser-216, a process inhibited by CDC20 (PubMed:18794143). Interacts with HSP90AA1 and HSP90AB1 (PubMed:26517842).

    Three dimensional structures from OCA and Proteopedia for HSF1 Gene

    Alternative splice isoforms for HSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF1 Gene

Post-translational modifications for HSF1 Gene

  • Acetylated on Lys-118; this acetylation is decreased in a IER5-dependent manner (PubMed:26754925). Acetylated on Lys-118, Lys-208 and Lys-298; these acetylations occur in a EP300-dependent manner (PubMed:24581496, PubMed:27189267). Acetylated on Lys-80; this acetylation inhibits DNA-binding activity upon heat shock (PubMed:19229036). Deacetylated on Lys-80 by SIRT1; this deacetylation increases DNA-binding activity (PubMed:19229036).
  • Phosphorylated (PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:26159920). Phosphorylated in unstressed cells; this phosphorylation is constitutive and implicated in the repression of HSF1 transcriptional activity (PubMed:8946918, PubMed:8940068, PubMed:9121459, PubMed:16278218). Phosphorylated on Ser-121 by MAPKAPK2; this phosphorylation promotes interaction with HSP90 proteins and inhibits HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Phosphorylation on Ser-303 by GSK3B/GSK3-beta and on Ser-307 by MAPK3 within the regulatory domain is involved in the repression of HSF1 transcriptional activity and occurs in a RAF1-dependent manner (PubMed:8946918, PubMed:8940068, PubMed:9121459, PubMed:9535852, PubMed:10747973, PubMed:12646186). Phosphorylation on Ser-303 and Ser-307 increases HSF1 nuclear export in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Phosphorylation on Ser-307 is a prerequisite for phosphorylation on Ser-303 (PubMed:8940068). According to PubMed:9535852, Ser-303 is not phosphorylated in unstressed cells. Phosphorylated on Ser-419 by PLK1; phosphorylation promotes nuclear translocation upon heat shock (PubMed:15661742). Hyperphosphorylated upon heat shock and during the attenuation and recovery phase period of the heat shock response (PubMed:11447121, PubMed:12659875, PubMed:24581496). Phosphorylated on Thr-142; this phosphorylation increases HSF1 transactivation activity upon heat shock (PubMed:12659875). Phosphorylation on Ser-230 by CAMK2A; this phosphorylation enhances HSF1 transactivation activity upon heat shock (PubMed:11447121). Phosphorylation on Ser-326 by MAPK12; this phosphorylation enhances HSF1 nuclear translocation, homotrimerization and transactivation activities upon heat shock (PubMed:15760475, PubMed:27354066). Phosphorylated on Ser-320 by PRKACA/PKA; this phosphorylation promotes nuclear localization and transcriptional activity upon heat shock (PubMed:21085490). Phosphorylated on Ser-363 by MAPK8; this phosphorylation occurs upon heat shock, induces HSF1 translocation into nuclear stress bodies and negatively regulates transactivation activity (PubMed:10747973). Neither basal nor stress-inducible phosphorylation on Ser-230, Ser-292, Ser-303, Ser-307, Ser-314, Ser-319, Ser-320, Thr-323, Ser-326, Ser-338, Ser-344, Ser-363, Thr-367, Ser-368 and Thr-369 within the regulatory domain is involved in the regulation of HSF1 subcellular localization or DNA-binding activity; however, it negatively regulates HSF1 transactivation activity (PubMed:25963659). Phosphorylated on Ser-216 by PLK1 in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex inducing HSF1 degradation, and hence mitotic progression (PubMed:18794143). Dephosphorylated on Ser-121, Ser-307, Ser-314, Thr-323 and Thr-367 by phosphatase PPP2CA in an IER5-dependent manner, leading to HSF1-mediated transactivation activity (PubMed:26754925).
  • Sumoylated with SUMO1 and SUMO2 upon heat shock in a ERK2-dependent manner (PubMed:12646186, PubMed:12665592). Sumoylated by SUMO1 on Lys-298; sumoylation occurs upon heat shock and promotes its localization to nuclear stress bodies and DNA-binding activity (PubMed:11514557). Phosphorylation on Ser-303 and Ser-307 is probably a prerequisite for sumoylation (PubMed:12646186, PubMed:12665592).
  • Ubiquitinated by SCF(BTRC) and degraded following stimulus-dependent phosphorylation at Ser-216 by PLK1 in mitosis (PubMed:18794143). Polyubiquitinated (PubMed:24581496). Undergoes proteasomal degradation upon heat shock and during the attenuation and recovery phase period of the heat shock response (PubMed:24581496).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSF1 Gene

Domains & Families for HSF1 Gene

Gene Families for HSF1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HSF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00613

UniProtKB/Swiss-Prot:

HSF1_HUMAN :
  • In unstressed cells, spontaneous homotrimerization is inhibited (PubMed:7935471, PubMed:7760831). Intramolecular interactions between the hydrophobic repeat HR-A/B and HR-C regions are necessary to maintain HSF1 in the inactive, monomeric conformation (PubMed:7935471, PubMed:7623826). Furthermore, intramolecular interactions between the regulatory domain and the nonadjacent transactivation domain prevents transcriptional activation, a process that is relieved upon heat shock (PubMed:7760831). The regulatory domain is necessary for full repression of the transcriptional activation domain in unstressed cells through its phosphorylation on Ser-303 and Ser-307 (PubMed:8946918, PubMed:9121459). In heat stressed cells, HSF1 homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity (PubMed:7935471). The D domain is necessary for translocation to the nucleus, interaction with JNK1 and MAPK3 and efficient JNK1- and MAPK3-dependent phosphorylation (PubMed:10747973). The regulatory domain confers heat shock inducibility on the transcriptional transactivation domain (PubMed:7760831). The regulatory domain is necessary for transcriptional activation through its phosphorylation on Ser-230 upon heat shock (PubMed:11447121). 9aaTAD is a transactivation motif present in a large number of yeast and animal transcription factors (PubMed:17467953).
  • Belongs to the HSF family.
Domain:
  • In unstressed cells, spontaneous homotrimerization is inhibited (PubMed:7935471, PubMed:7760831). Intramolecular interactions between the hydrophobic repeat HR-A/B and HR-C regions are necessary to maintain HSF1 in the inactive, monomeric conformation (PubMed:7935471, PubMed:7623826). Furthermore, intramolecular interactions between the regulatory domain and the nonadjacent transactivation domain prevents transcriptional activation, a process that is relieved upon heat shock (PubMed:7760831). The regulatory domain is necessary for full repression of the transcriptional activation domain in unstressed cells through its phosphorylation on Ser-303 and Ser-307 (PubMed:8946918, PubMed:9121459). In heat stressed cells, HSF1 homotrimerization occurs through formation of a three-stranded coiled-coil structure generated by intermolecular interactions between HR-A/B regions allowing DNA-binding activity (PubMed:7935471). The D domain is necessary for translocation to the nucleus, interaction with JNK1 and MAPK3 and efficient JNK1- and MAPK3-dependent phosphorylation (PubMed:10747973). The regulatory domain confers heat shock inducibility on the transcriptional transactivation domain (PubMed:7760831). The regulatory domain is necessary for transcriptional activation through its phosphorylation on Ser-230 upon heat shock (PubMed:11447121). 9aaTAD is a transactivation motif present in a large number of yeast and animal transcription factors (PubMed:17467953).
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF1: view

Function for HSF1 Gene

Molecular function for HSF1 Gene

GENATLAS Biochemistry:
heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited through complex with HSP90
UniProtKB/Swiss-Prot Function:
Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults damage (PubMed:1871105, PubMed:11447121, PubMed:1986252, PubMed:7760831, PubMed:7623826, PubMed:8946918, PubMed:8940068, PubMed:9341107, PubMed:9121459, PubMed:9727490, PubMed:9499401, PubMed:9535852, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:25963659, PubMed:26754925). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490, PubMed:11583998, PubMed:16278218). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105, PubMed:1986252, PubMed:8455624, PubMed:7935471, PubMed:7623826, PubMed:8940068, PubMed:9727490, PubMed:9499401, PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:25963659, PubMed:26754925). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5-NGAAN-3 pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300.

Phenotypes From GWAS Catalog for HSF1 Gene

Gene Ontology (GO) - Molecular Function for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8926278
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8926278
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0003677 DNA binding IDA,IEA 7760831
genes like me logo Genes that share ontologies with HSF1: view
genes like me logo Genes that share phenotypes with HSF1: view

Animal Models for HSF1 Gene

MGI Knock Outs for HSF1:

Animal Model Products

CRISPR Products

miRNA for HSF1 Gene

miRTarBase miRNAs that target HSF1
Targeted motifs for HSF1 Gene
HOMER Transcription Factor Regulatory Elements motif HSF1
  • Consensus sequence: NNTTCTGGAANNTTCTAGAA Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSF1
  • Applied Biological Materials Clones for HSF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HSF1 Gene

Localization for HSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF1 Gene

Nucleus. Cytoplasm. Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Note=The monomeric form is cytoplasmic in unstressed cells (PubMed:8455624, PubMed:26159920). Predominantly nuclear protein in both unstressed and heat shocked cells (PubMed:10413683, PubMed:10359787). Translocates in the nucleus upon heat shock (PubMed:8455624). Nucleocytoplasmic shuttling protein (PubMed:26159920). Colocalizes with IER5 in the nucleus (PubMed:27354066). Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:8455624, PubMed:26159920). Localizes in subnuclear granules called nuclear stress bodies (nSBs) upon heat shock (PubMed:11447121, PubMed:11514557, PubMed:10359787, PubMed:25963659, PubMed:10747973, PubMed:24581496, PubMed:19229036). Colocalizes with SYMPK and SUMO1 in nSBs upon heat shock (PubMed:11447121, PubMed:12665592, PubMed:11514557, PubMed:14707147, PubMed:10359787). Colocalizes with PRKACA/PKA in the nucleus and nSBs upon heat shock (PubMed:21085490). Relocalizes from the nucleus to the cytoplasm during the attenuation and recovery phase period of the heat shock response (PubMed:26159920). Translocates in the cytoplasm in a YWHAE- and XPO1/CRM1-dependent manner (PubMed:12917326). Together with histone H2AX, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) (PubMed:26359349). Colocalizes with calcium-responsive transactivator SS18L1 at kinetochore region on the mitotic chromosomes (PubMed:18794143). Colocalizes with gamma tubulin at centrosome (PubMed:18794143). Localizes at spindle pole in metaphase (PubMed:18794143). Colocalizes with PLK1 at spindle poles during prometaphase (PubMed:18794143). {ECO:0000269 PubMed:10359787, ECO:0000269 PubMed:10413683, ECO:0000269 PubMed:10747973, ECO:0000269 PubMed:11447121, ECO:0000269 PubMed:11514557, ECO:0000269 PubMed:12665592, ECO:0000269 PubMed:12917326, ECO:0000269 PubMed:14707147, ECO:0000269 PubMed:18794143, ECO:0000269 PubMed:21085490, ECO:0000269 PubMed:24581496, ECO:0000269 PubMed:25963659, ECO:0000269 PubMed:26159920, ECO:0000269 PubMed:26359349, ECO:0000269 PubMed:27354066, ECO:0000269 PubMed:8455624}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSF1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IDA,IEA 18794143
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000791 euchromatin IEA --
GO:0000792 heterochromatin IEA --
genes like me logo Genes that share ontologies with HSF1: view

Pathways & Interactions for HSF1 Gene

genes like me logo Genes that share pathways with HSF1: view

Pathways by source for HSF1 Gene

1 Cell Signaling Technology pathway for HSF1 Gene
1 KEGG pathway for HSF1 Gene

SIGNOR curated interactions for HSF1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8926278
GO:0000165 MAPK cascade IDA 12917326
GO:0001701 in utero embryonic development IEA --
GO:0001892 embryonic placenta development IEA --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with HSF1: view

Drugs & Compounds for HSF1 Gene

(44) Drugs for HSF1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIMOCLOMOL Pharma 0

(27) Additional Compounds for HSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF1: view

Transcripts for HSF1 Gene

Unigene Clusters for HSF1 Gene

Heat shock transcription factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSF1
  • Applied Biological Materials Clones for HSF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7:
SP8: -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: - -
SP13: - -
SP14:
SP15: - - -

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for HSF1 Gene

GeneLoc Exon Structure for
HSF1
ECgene alternative splicing isoforms for
HSF1

Expression for HSF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSF1 Gene

Protein differential expression in normal tissues from HIPED for HSF1 Gene

This gene is overexpressed in Liver (46.5) and Kidney (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSF1 Gene



Protein tissue co-expression partners for HSF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF1 Gene:

HSF1

SOURCE GeneReport for Unigene cluster for HSF1 Gene:

Hs.530227

Evidence on tissue expression from TISSUES for HSF1 Gene

  • Muscle(4.6)
  • Nervous system(4.5)
  • Liver(4.4)
  • Lung(3.6)
  • Skin(3)
  • Intestine(2.8)
  • Heart(2.7)
  • Kidney(2.3)
genes like me logo Genes that share expression patterns with HSF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSF1 Gene

Orthologs for HSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSF1 33 34
  • 89.48 (n)
dog
(Canis familiaris)
Mammalia HSF1 33 34
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Hsf1 33
  • 87.6 (n)
mouse
(Mus musculus)
Mammalia Hsf1 33 16 34
  • 87.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF1 34
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF1 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489822 33
  • 71.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1051 33
zebrafish
(Danio rerio)
Actinopterygii hsf1 33 34
  • 68.05 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3625 33
fruit fly
(Drosophila melanogaster)
Insecta Hsf 35 34
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 35
  • 32 (a)
hsf-1 34
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 34
  • 14 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9998 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2885 33
Species where no ortholog for HSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF1 Gene

ENSEMBL:
Gene Tree for HSF1 (if available)
TreeFam:
Gene Tree for HSF1 (if available)

Paralogs for HSF1 Gene

Paralogs for HSF1 Gene

(2) SIMAP similar genes for HSF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSF1: view

Variants for HSF1 Gene

Sequence variations from dbSNP and Humsavar for HSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000290335 -- 144,294,665(+) CCCAC(C/T)GCAGC intron-variant
rs1000388583 -- 144,304,148(+) GGGGA(C/G)AAGGG intron-variant
rs1000414615 -- 144,299,250(+) CAGCC(C/T)GGCCA intron-variant
rs1000797555 -- 144,307,878(+) TTCTT(C/T)GGTTA intron-variant, upstream-variant-2KB
rs1000828949 -- 144,308,035(+) CTTCT(A/G)GTGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSF1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
esv25318 CNV gain 19812545
esv2658902 CNV deletion 23128226
esv2759652 CNV gain+loss 17122850
esv3619126 CNV loss 21293372
nsv1025071 CNV gain 25217958
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612919 CNV gain 21841781
nsv824804 CNV gain 20364138

Variation tolerance for HSF1 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.97; 59.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF1 Gene

Disorders for HSF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
synucleinopathy
  • alpha synucleinopathies
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HSF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF1

Genetic Association Database (GAD)
HSF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF1
genes like me logo Genes that share disorders with HSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF1 Gene

Publications for HSF1 Gene

  1. HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression. (PMID: 18794143) Lee YJ … Lee YS (Cancer research 2008) 3 4 22 60
  2. RNA-mediated response to heat shock in mammalian cells. (PMID: 16554823) Shamovsky I … Nudler E (Nature 2006) 3 4 22 60
  3. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. (PMID: 15760475) Guettouche T … Voellmy R (BMC biochemistry 2005) 3 4 22 60
  4. Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress. (PMID: 15661742) Kim SA … Ahn SG (The Journal of biological chemistry 2005) 3 4 22 60
  5. DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. (PMID: 15016915) Boellmann F … Voellmy R (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 22 60

Products for HSF1 Gene

  • Addgene plasmids for HSF1

Sources for HSF1 Gene

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