Aliases for HSF1 Gene
External Ids for HSF1 Gene
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HSF1 Gene
HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and TGF-Beta Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is HSF2.
UniProtKB/Swiss-Prot for HSF1 Gene
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.