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Aliases for HSF1 Gene

Aliases for HSF1 Gene

  • Heat Shock Transcription Factor 1 2 3 4 5
  • HSTF 1 3 4
  • HSTF1 3 4
  • HSF 1 3 4

External Ids for HSF1 Gene

Previous GeneCards Identifiers for HSF1 Gene

  • GC08P143129
  • GC08U900025
  • GC08P145120
  • GC08P145520
  • GC08P145486
  • GC08P145515
  • GC08P140629

Summaries for HSF1 Gene

Entrez Gene Summary for HSF1 Gene

  • The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSF1 Gene

HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Amyotrophic Lateral Sclerosis 1. Among its related pathways are Cellular response to heat stress and HSF1-dependent transactivation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HSF2.

UniProtKB/Swiss-Prot for HSF1 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF1 Gene

Genomics for HSF1 Gene

Regulatory Elements for HSF1 Gene

Enhancers for HSF1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSF1 on UCSC Golden Path with GeneCards custom track

Promoters for HSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSF1 Gene

144,291,588 bp from pter
144,314,722 bp from pter
23,135 bases
Plus strand

Genomic View for HSF1 Gene

Genes around HSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF1 Gene

Proteins for HSF1 Gene

  • Protein details for HSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heat shock factor protein 1
    Protein Accession:
    Secondary Accessions:
    • A8K4L0
    • A8MW26
    • Q53XT4

    Protein attributes for HSF1 Gene

    529 amino acids
    Molecular mass:
    57260 Da
    Quaternary structure:
    • Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the interaction prevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such as metal ions, HSF1 is released from the complex, homotrimerizes, is hyperphosphorylated and translocated to the nucleus where, subsequently, it can activate transcription. Binds the complex through the regulatory domain. Interacts with SYMPK and CSTF2 in heat-stressed cells. Interacts with FKBP4 in the HSP90 multichaperone complex; the interaction is independent of the phosphorylation state of HSF1. Interacts with MAPKAPK2. Interacts with EEF1D at heat shock promoter elements (HSE).

    Three dimensional structures from OCA and Proteopedia for HSF1 Gene

    Alternative splice isoforms for HSF1 Gene


neXtProt entry for HSF1 Gene

Proteomics data for HSF1 Gene at MOPED

Post-translational modifications for HSF1 Gene

  • Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation of transcription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures. Levels increase on specific residues heat-shock and enhance HSF1 transactivation activity. Phosphorylation on Ser-307 derepresses activation on heat-stress and in combination with Ser-303 phosphorylation appears to be involved in recovery after heat-stress. Phosphorylated on Ser-230 by CAMK2, in vitro. Cadmium also enhances phosphorylation at this site. Phosphorylation on Ser-303 is a prerequisite for HSF1 sumoylation. Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding. Phosphorylation on Thr-142 also mediates transcriptional activity induced by heat. Phosphorylation on Ser-326 plays an important role in heat activation of HSF1 transcriptional activity.
  • Sumoylated with SUMO1 and SUMO2 on heat-shock. Heat-inducible sumoylation occurs after 15 min of heat-shock, after which levels decrease and at 4 hours, levels return to control levels. Sumoylation has no effect on HSE binding nor on transcriptional activity. Phosphorylation on Ser-303 is a prerequisite for sumoylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSF1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HSF1 (HSF1)
  • Abcam antibodies for HSF1

No data available for DME Specific Peptides for HSF1 Gene

Domains & Families for HSF1 Gene

Suggested Antigen Peptide Sequences for HSF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the HSF family.
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF1: view

No data available for Gene Families for HSF1 Gene

Function for HSF1 Gene

Molecular function for HSF1 Gene

GENATLAS Biochemistry:
heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited through complex with HSP90
UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Ontology (GO) - Molecular Function for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 11005381
genes like me logo Genes that share ontologies with HSF1: view
genes like me logo Genes that share phenotypes with HSF1: view

Animal Models for HSF1 Gene

MGI Knock Outs for HSF1:

Animal Model Products

miRNA for HSF1 Gene

miRTarBase miRNAs that target HSF1
Targeted motifs for HSF1 Gene
HOMER Transcription Factor Regulatory Elements motif HSF1
  • Consensus sequence: NNTTCTGGAANNTTCTAGAA Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HSF1 Gene

Localization for HSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.

Subcellular locations from

Jensen Localization Image for HSF1 Gene COMPARTMENTS Subcellular localization image for HSF1 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for HSF1 Gene

Pathways & Interactions for HSF1 Gene

genes like me logo Genes that share pathways with HSF1: view

Pathways by source for HSF1 Gene

1 Cell Signaling Technology pathway for HSF1 Gene
1 KEGG pathway for HSF1 Gene

SIGNOR curated interactions for HSF1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8926278
GO:0001892 embryonic placenta development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009299 mRNA transcription IDA 21597468
GO:0032496 response to lipopolysaccharide IEA --
genes like me logo Genes that share ontologies with HSF1: view

Drugs & Compounds for HSF1 Gene

(42) Drugs for HSF1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(29) Additional Compounds for HSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF1: view

Transcripts for HSF1 Gene

Unigene Clusters for HSF1 Gene

Heat shock transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP8: -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: - -
SP13: - -
SP15: - - -

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - -
SP8: - - -

Relevant External Links for HSF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSF1 Gene

mRNA expression in normal human tissues for HSF1 Gene

Protein differential expression in normal tissues from HIPED for HSF1 Gene

This gene is overexpressed in Liver (46.5) and Kidney (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSF1 Gene

SOURCE GeneReport for Unigene cluster for HSF1 Gene Hs.530227

genes like me logo Genes that share expression patterns with HSF1: view

Protein tissue co-expression partners for HSF1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSF1 Gene

Orthologs for HSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSF1 35
  • 89.48 (n)
  • 91.59 (a)
HSF1 36
  • 90 (a)
(Canis familiaris)
Mammalia HSF1 35
  • 88.83 (n)
  • 92.19 (a)
HSF1 36
  • 92 (a)
(Mus musculus)
Mammalia Hsf1 35
  • 87.52 (n)
  • 90.44 (a)
Hsf1 16
Hsf1 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Hsf1 35
  • 87.6 (n)
  • 90.65 (a)
(Monodelphis domestica)
Mammalia HSF1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HSF1 36
  • 64 (a)
(Gallus gallus)
Aves HSF1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia HSF1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489822 35
  • 71.56 (n)
  • 70.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1051 35
(Danio rerio)
Actinopterygii hsf1 35
  • 68.05 (n)
  • 64.66 (a)
hsf1 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3625 35
fruit fly
(Drosophila melanogaster)
Insecta Hsf 37
  • 56 (a)
Hsf 36
  • 24 (a)
(Caenorhabditis elegans)
Secernentea Y53C10A.12 37
  • 32 (a)
hsf-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 36
  • 14 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9998 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2885 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for HSF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF1 Gene

Gene Tree for HSF1 (if available)
Gene Tree for HSF1 (if available)

Paralogs for HSF1 Gene

Paralogs for HSF1 Gene

(2) SIMAP similar genes for HSF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSF1: view

Variants for HSF1 Gene

Sequence variations from dbSNP and Humsavar for HSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs7836206 -- 144,294,895(+) ATCCC(A/G)GGGAT intron-variant
rs3757975 -- 144,313,339(-) GGAGG(C/G)TCTGT intron-variant
rs3757976 -- 144,313,067(-) AGCCC(C/T)AGGCC intron-variant, downstream-variant-500B
rs3757977 -- 144,310,288(-) GTGGG(A/G)CAGCG intron-variant, upstream-variant-2KB
rs4256628 -- 144,308,151(+) CAGCC(A/G)CCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSF1 Gene

Variant ID Type Subtype PubMed ID
dgv7940n71 CNV Loss 21882294
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
dgv7955n71 CNV Loss 21882294
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7957n71 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv8396 CNV Gain 18304495
dgv7960n71 CNV Loss 21882294
nsv891832 CNV Gain+Loss 21882294
nsv891838 CNV Gain 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv824804 CNV Gain 20364138
nsv891842 CNV Gain+Loss 21882294
nsv891843 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
esv2658902 CNV Deletion 23128226
dgv7962n71 CNV Loss 21882294
esv25318 CNV Gain 19812545
esv1341308 CNV Deletion 17803354

Variation tolerance for HSF1 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.97; 59.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSF1 Gene

Disorders for HSF1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSF1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HSF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF1 Gene

Publications for HSF1 Gene

  1. Molecular cloning and expression of a human heat shock factor, HSF1. (PMID: 1871105) Rabindran S.K. … Wu C. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 67
  2. Heat shock factor 1 binds to and transcribes satellite II and III sequences at several pericentromeric regions in heat-shocked cells. (PMID: 20152833) Eymery A. … Jolly C. (Exp. Cell Res. 2010) 3 23
  3. AIRAP, a new human heat shock gene regulated by heat shock factor 1. (PMID: 20185824) Rossi A. … Santoro M.G. (J. Biol. Chem. 2010) 3 23
  4. The antitumor effect of PLK1 and HSF1 double knockdown on human oral carcinoma cells. (PMID: 20198330) Kim S.A. … Ahn S.G. (Int. J. Oncol. 2010) 3 23
  5. Aberrant regulation and modification of heat shock factor 1 in senescent human diploid fibroblasts. (PMID: 19097133) Lee Y.K. … Liu A.Y. (J. Cell. Biochem. 2009) 3 23

Products for HSF1 Gene

Sources for HSF1 Gene