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Aliases for HSF1 Gene

Aliases for HSF1 Gene

  • Heat Shock Transcription Factor 1 2 3 4 5
  • HSTF1 3 4
  • Heat Shock Factor Protein 1 3
  • HSTF 1 4
  • HSF 1 4

External Ids for HSF1 Gene

Previous GeneCards Identifiers for HSF1 Gene

  • GC08P143129
  • GC08U900025
  • GC08P145120
  • GC08P145520
  • GC08P145486
  • GC08P145515
  • GC08P140629

Summaries for HSF1 Gene

Entrez Gene Summary for HSF1 Gene

  • The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phsphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Aug 2016]

GeneCards Summary for HSF1 Gene

HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Synucleinopathy and Amyotrophic Lateral Sclerosis 1. Among its related pathways are HSF1-dependent transactivation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HSF4.

UniProtKB/Swiss-Prot for HSF1 Gene

  • DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Wiki entry for HSF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSF1 Gene

Genomics for HSF1 Gene

Regulatory Elements for HSF1 Gene

Enhancers for HSF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144455 0.8 Ensembl ENCODE 13.7 +164.9 164859 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F144313 0.2 ENCODE 12.1 +23.7 23674 2.9 ARID4B SIN3A ZNF48 GLIS2 GATA2 KLF13 REST SSRP1 SMARCA4 GLIS1 MAF1 BOP1 HSF1 VPS28 ENSG00000254690 MIR6848
GH08F144184 1.3 Ensembl ENCODE 11.9 -106.3 -106277 1.4 HDGF PKNOX1 BHLHE40 RELA ARID3A IKZF1 CTBP2 NBN SPI1 ZC3H3 BOP1 HSF1 ENSG00000254690 DGAT1 MIR6848 WDR97 ZNF251 ENSG00000255224 PIR45617
GH08F144180 1.2 VISTA ENCODE 11.9 -110.1 -110128 1.7 ZBTB33 KDM1A NR3C1 ZBTB7A BOP1 HSF1 ENSG00000254690 DGAT1 MIR6848 ZNF251 WDR97 PIR45617 SCX
GH08F144178 0.5 ENCODE 11.9 -112.5 -112532 0.5 BOP1 HSF1 ENSG00000254690 DGAT1 MIR6848 WDR97 PIR45617 SCX
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HSF1 on UCSC Golden Path with GeneCards custom track

Promoters for HSF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001446429 -88 2601 ATF1 PKNOX1 ARID4B SIN3A YY1 ELK1 GATA2 ZNF143 NFYC ZHX2

Genomic Location for HSF1 Gene

Chromosome:
8
Start:
144,291,588 bp from pter
End:
144,314,722 bp from pter
Size:
23,135 bases
Orientation:
Plus strand

Genomic View for HSF1 Gene

Genes around HSF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSF1 Gene

Proteins for HSF1 Gene

  • Protein details for HSF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00613-HSF1_HUMAN
    Recommended name:
    Heat shock factor protein 1
    Protein Accession:
    Q00613
    Secondary Accessions:
    • A8K4L0
    • A8MW26
    • Q53XT4

    Protein attributes for HSF1 Gene

    Size:
    529 amino acids
    Molecular mass:
    57260 Da
    Quaternary structure:
    • Monomer. Under normal conditions, interacts with HSP90AA1 in the HSP90 multichaperone complex; the interaction prevents trimerization and activation of HSF1. On activation by heat-stress or by other factors such as metal ions, HSF1 is released from the complex, homotrimerizes, is hyperphosphorylated and translocated to the nucleus where, subsequently, it can activate transcription. Binds the complex through the regulatory domain. Interacts with SYMPK and CSTF2 in heat-stressed cells. Interacts with FKBP4 in the HSP90 multichaperone complex; the interaction is independent of the phosphorylation state of HSF1. Interacts with MAPKAPK2. Interacts with EEF1D at heat shock promoter elements (HSE).

    Three dimensional structures from OCA and Proteopedia for HSF1 Gene

    Alternative splice isoforms for HSF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSF1 Gene

Post-translational modifications for HSF1 Gene

  • Phosphorylated on multiple serine residues, a subset of which are involved in stress-related regulation of transcription activation. Constitutive phosphorylation represses transcriptional activity at normal temperatures. Levels increase on specific residues heat-shock and enhance HSF1 transactivation activity. Phosphorylation on Ser-307 derepresses activation on heat-stress and in combination with Ser-303 phosphorylation appears to be involved in recovery after heat-stress. Phosphorylated on Ser-230 by CAMK2, in vitro. Cadmium also enhances phosphorylation at this site. Phosphorylation on Ser-303 is a prerequisite for HSF1 sumoylation. Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding. Phosphorylation on Thr-142 also mediates transcriptional activity induced by heat. Phosphorylation on Ser-326 plays an important role in heat activation of HSF1 transcriptional activity.
  • Sumoylated with SUMO1 and SUMO2 on heat-shock. Heat-inducible sumoylation occurs after 15 min of heat-shock, after which levels decrease and at 4 hours, levels return to control levels. Sumoylation has no effect on HSE binding nor on transcriptional activity. Phosphorylation on Ser-303 is a prerequisite for sumoylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HSF1 Gene

Domains & Families for HSF1 Gene

Suggested Antigen Peptide Sequences for HSF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00613

UniProtKB/Swiss-Prot:

HSF1_HUMAN :
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
  • Belongs to the HSF family.
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Family:
  • Belongs to the HSF family.
genes like me logo Genes that share domains with HSF1: view

No data available for Gene Families for HSF1 Gene

Function for HSF1 Gene

Molecular function for HSF1 Gene

GENATLAS Biochemistry:
heat shock factor 1,interacting with heat shock proteins through their heat shock element (HSE),inhibited through complex with HSP90
UniProtKB/Swiss-Prot Function:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Gene Ontology (GO) - Molecular Function for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8926278
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8926278
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 10561509
GO:0003677 DNA binding IEA,IDA 7760831
genes like me logo Genes that share ontologies with HSF1: view
genes like me logo Genes that share phenotypes with HSF1: view

Animal Models for HSF1 Gene

MGI Knock Outs for HSF1:

Animal Model Products

miRNA for HSF1 Gene

miRTarBase miRNAs that target HSF1
Targeted motifs for HSF1 Gene
HOMER Transcription Factor Regulatory Elements motif HSF1
  • Consensus sequence: NNTTCTGGAANNTTCTAGAA Submotif: canonical Cell Type: HepG2 GEO ID: GSE31477

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSF1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HSF1 Gene

Localization for HSF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSF1 Gene

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSF1 Gene COMPARTMENTS Subcellular localization image for HSF1 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000791 euchromatin IEA --
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA,IDA 8455624
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 8455624
genes like me logo Genes that share ontologies with HSF1: view

Pathways & Interactions for HSF1 Gene

genes like me logo Genes that share pathways with HSF1: view

Pathways by source for HSF1 Gene

1 Cell Signaling Technology pathway for HSF1 Gene
1 KEGG pathway for HSF1 Gene

SIGNOR curated interactions for HSF1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HSF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8926278
GO:0001701 in utero embryonic development IEA --
GO:0001892 embryonic placenta development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HSF1: view

Drugs & Compounds for HSF1 Gene

(44) Drugs for HSF1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BIMOCLOMOL Pharma 0

(27) Additional Compounds for HSF1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HSF1: view

Transcripts for HSF1 Gene

Unigene Clusters for HSF1 Gene

Heat shock transcription factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HSF1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: - - - - - - - - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7:
SP8: -
SP9: -
SP10: - - - - -
SP11: - - - - -
SP12: - -
SP13: - -
SP14:
SP15: - - -

ExUns: 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c · 19d
SP1: - -
SP2: - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for HSF1 Gene

GeneLoc Exon Structure for
HSF1
ECgene alternative splicing isoforms for
HSF1

Expression for HSF1 Gene

mRNA expression in normal human tissues for HSF1 Gene

Protein differential expression in normal tissues from HIPED for HSF1 Gene

This gene is overexpressed in Liver (46.5) and Kidney (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSF1 Gene



Protein tissue co-expression partners for HSF1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSF1 Gene:

HSF1

SOURCE GeneReport for Unigene cluster for HSF1 Gene:

Hs.530227
genes like me logo Genes that share expression patterns with HSF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HSF1 Gene

Orthologs for HSF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSF1 34 35
  • 89.48 (n)
dog
(Canis familiaris)
Mammalia HSF1 34 35
  • 88.83 (n)
rat
(Rattus norvegicus)
Mammalia Hsf1 34
  • 87.6 (n)
mouse
(Mus musculus)
Mammalia Hsf1 34 16 35
  • 87.52 (n)
oppossum
(Monodelphis domestica)
Mammalia HSF1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSF1 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSF1 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSF1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489822 34
  • 71.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1051 34
zebrafish
(Danio rerio)
Actinopterygii hsf1 34 35
  • 68.05 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3625 34
fruit fly
(Drosophila melanogaster)
Insecta Hsf 36 35
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.12 36
  • 32 (a)
hsf-1 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSF1 35
  • 14 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9998 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2885 34
Species where no ortholog for HSF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSF1 Gene

ENSEMBL:
Gene Tree for HSF1 (if available)
TreeFam:
Gene Tree for HSF1 (if available)

Paralogs for HSF1 Gene

Paralogs for HSF1 Gene

(2) SIMAP similar genes for HSF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HSF1: view

Variants for HSF1 Gene

Sequence variations from dbSNP and Humsavar for HSF1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10093866 -- 144,290,137(+) gtgga(C/T)cacct intron-variant, upstream-variant-2KB
rs1042568 -- 144,314,666(+) TACAC(A/C)CAGTG nc-transcript-variant, utr-variant-3-prime
rs111232249 -- 144,290,122(+) GGGAG(A/G)CTGAG intron-variant, upstream-variant-2KB
rs111264872 -- 144,306,248(+) TTTTG(A/G)CTTCT intron-variant
rs111439166 -- 144,308,426(+) GAACG(C/T)GACTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HSF1 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
esv25318 CNV gain 19812545
esv2658902 CNV deletion 23128226
esv2759652 CNV gain+loss 17122850
esv3619126 CNV loss 21293372
nsv1025071 CNV gain 25217958
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612919 CNV gain 21841781
nsv824804 CNV gain 20364138

Variation tolerance for HSF1 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.97; 59.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSF1 Gene

Disorders for HSF1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HSF1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
synucleinopathy
  • alpha synucleinopathies
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HSF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HSF1

Genetic Association Database (GAD)
HSF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSF1
genes like me logo Genes that share disorders with HSF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSF1 Gene

Publications for HSF1 Gene

  1. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. (PMID: 15760475) Guettouche T. … Voellmy R. (BMC Biochem. 2005) 3 4 22 64
  2. HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin. (PMID: 14707147) Xing H. … Sarge K.D. (J. Biol. Chem. 2004) 3 4 22 64
  3. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. (PMID: 12659875) Soncin F. … Calderwood S.K. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  4. Phosphorylation of serine 303 is a prerequisite for the stress- inducible SUMO modification of heat shock factor 1. (PMID: 12665592) Hietakangas V. … Sistonen L. (Mol. Cell. Biol. 2003) 3 4 22 64
  5. Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification. (PMID: 11514557) Hong Y. … Sarge K.D. (J. Biol. Chem. 2001) 3 4 22 64

Products for HSF1 Gene

Sources for HSF1 Gene

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