Aliases for HSF1 Gene
External Ids for HSF1 Gene
Previous GeneCards Identifiers for HSF1 Gene
The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phsphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Aug 2016]
GeneCards Summary for HSF1 Gene
HSF1 (Heat Shock Transcription Factor 1) is a Protein Coding gene. Diseases associated with HSF1 include Synucleinopathy and Amyotrophic Lateral Sclerosis 1. Among its related pathways are HSF1-dependent transactivation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HSF4.
UniProtKB/Swiss-Prot for HSF1 Gene
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.