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HSDL2 Gene

protein-coding   GIFtS: 53
GCID: GC09P115142

Hydroxysteroid Dehydrogenase Like 2

(Previous name: chromosome 9 open reading frame 99)
(Previous symbol: C9orf99)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hydroxysteroid Dehydrogenase Like 21 2     Hydroxysteroid Dehydrogenase-Like Protein 22
C9orf991 2 3     Short Chain Dehydrogenase/Reductase Family 13C, Member 12
Chromosome 9 Open Reading Frame 991     EC 1.-.-.-3
Member 11     EC 1.1.18
Short Chain Dehydrogenase/Reductase Family 13C1     EC 1.1.1.1008
SDR13C12     

External Ids:    HGNC: 185721   Entrez Gene: 842632   Ensembl: ENSG000001194717   UniProtKB: Q6YN163   

Export aliases for HSDL2 gene to outside databases

Previous GC identifers: GC09P112222 GC09P114182 GC09P084741


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSDL2 Gene:
HSDL2 (hydroxysteroid dehydrogenase like 2) is a protein-coding gene. Diseases associated with HSDL2 include cleft lip, and atherosclerosis. GO annotations related to this gene include oxidoreductase activity and sterol binding.

UniProtKB/Swiss-Prot: HSDL2_HUMAN, Q6YN16
Function: Has apparently no steroid dehydrogenase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSDL2 gene promoter:
         ER-alpha   COUP-TF1   HSF1 (long)   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSDL2 promoter sequence
   Search Chromatin IP Primers for HSDL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSDL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

HSDL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSDL2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P115142:  view genomic region     (about GC identifiers)

Start:
115,142,189 bp from pter      End:
115,234,690 bp from pter
Size:
92,502 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HSDL2_HUMAN, Q6YN16 (See protein sequence)
Recommended Name: Hydroxysteroid dehydrogenase-like protein 2  
Size: 418 amino acids; 45395 Da
1 PDB 3D structure from and Proteopedia for HSDL2:
3KVO (3D)    
Secondary accessions: A8K1L4 A8K8X1 A8MSV3 Q658M8 Q9BT58
Alternative splicing: 2 isoforms:  Q6YN16-1   Q6YN16-2   

Explore the universe of human proteins at neXtProt for HSDL2: NX_Q6YN16

Explore proteomics data for HSDL2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys49
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for HSDL2 (Q6YN16)
     SRGIGKA  TGASRGIG 


    See HSDL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182751.1  NP_115679.2  

    ENSEMBL proteins: 
     ENSP00000381785   ENSP00000381783   ENSP00000262542   ENSP00000442278  

    HSDL2 Human Recombinant Protein Products:

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    Novus Biologicals HSDL2 Protein
    Novus Biologicals HSDL2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for HSDL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    5 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom
     IPR003033 SCP2_sterol-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q6YN16

    ProtoNet protein and cluster: Q6YN16

    3 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature
    IPB003033 Sterol-binding


    UniProtKB/Swiss-Prot: HSDL2_HUMAN, Q6YN16
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family
    Similarity: Contains 1 SCP2 domain


    HSDL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSDL2_HUMAN, Q6YN16
    Function: Has apparently no steroid dehydrogenase activity

         Enzyme Numbers (IUBMB): EC 1.1.1.1002 EC 1.1.12 EC 1.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016491oxidoreductase activity IEA--
    GO:0032934sterol binding IEA--
         
    HSDL2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HSDL2:
     Decreased Wnt reporter activit  Decreased viability  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSDL2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSDL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSDL2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSDL2:
    hsa-mir-328-3p (MIRT043745), hsa-mir-16-5p (MIRT000864), hsa-mir-15a-5p (MIRT000865)

    Block miRNA regulation of human, mouse, rat HSDL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSDL2 (see all 31):
    hsa-miR-323-3p hsa-miR-498 hsa-miR-607 hsa-miR-875-3p hsa-miR-448 hsa-miR-495 hsa-miR-300 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidHSDL2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSDL2

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    GenScript: all cDNA clones in your preferred vector (see all 2): HSDL2 (NM_032303)
    Sino Biological Human cDNA Clone for HSDL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSDL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSDL2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HSDL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSDL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSDL2_HUMAN, Q6YN16: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    mitochondrion3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005777peroxisome IDA19703561

    HSDL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSDL2
    Interactions:

        Search GeneGlobe Interaction Network for HSDL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HSDL2 (Q6YN163 ENSP000003817854) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    ATG10Q9H0Y03I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    CLN3Q132863I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0008152metabolic process ----

    HSDL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSDL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSDL2 gene (2 alternative transcripts): 
    NM_001195822.1  NM_032303.4  

    Unigene Cluster for HSDL2:

    Hydroxysteroid dehydrogenase like 2
    Hs.59486  [show with all ESTs]
    Unigene Representative Sequence: NM_032303
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398805(uc004bga.2 uc011lwv.2 uc004bgc.2 uc004bgb.2 uc011lww.2)
    ENST00000398803 ENST00000488101 ENST00000467434 ENST00000480881 ENST00000262542
    ENST00000539114
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSDL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSDL2 (see all 31):
    hsa-miR-323-3p hsa-miR-498 hsa-miR-607 hsa-miR-875-3p hsa-miR-448 hsa-miR-495 hsa-miR-300 hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidHSDL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSDL2
    Predesigned siRNA for gene silencing in human, mouse, rat HSDL2
    Clone
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    OriGene clones in human, mouse for HSDL2 (see all 9)
    OriGene ORF clones in mouse, rat for HSDL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HSDL2 (NM_032303)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSDL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSDL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSDL2
    OriGene qSTAR qPCR primer pairs in human, mouse for HSDL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSDL2
      QuantiTect SYBR Green Assays in human, mouse, rat HSDL2
      QuantiFast Probe-based Assays in human, mouse, rat HSDL2

    Additional mRNA sequence: 

    AK023959.1 AK090940.1 AK098721.1 AK225946.1 AK289929.1 AK292486.1 AK313605.1 AL050130.1 
    AL833735.1 AY093428.1 BC004331.1 BC095451.1 NR_036651.1 

    13 DOTS entries:

    DT.451395  DT.97858811  DT.99929521  DT.121195568  DT.121195638  DT.426506  DT.100037080  DT.100796747 
    DT.121611699  DT.95078502  DT.100841014  DT.92433862  DT.97858812 

    Selected AceView cDNA sequences (see all 321):

    AJ707764 BF509823 BF969827 C04804 BQ694534 CB115766 AA345403 AK090940 
    F23449 CA424646 AW044490 AA211903 CR614573 AI077381 BQ086273 BM712046 
    BX280967 AL701930 AA749291 AU142060 AA062584 BX439325 F36769 BM833960 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSDL2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                    -                                 
    SP2:                                            -     -                 -                                 
    SP3:                          -                                         -                                 
    SP4:                                -                 -     -           -                                 
    SP5:                          -                       -                 -                                 


    ECgene alternative splicing isoforms for HSDL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSDL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCGCTAAT
    HSDL2 Expression
    About this image


    HSDL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HSDL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSDL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59486

    UniProtKB/Swiss-Prot: HSDL2_HUMAN, Q6YN16
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for HSDL2
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    QuantiFast Probe-based Assays in human, mouse, rat HSDL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSDL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HSDL2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsdl25 hydroxysteroid dehydrogenase like 2   --   4 (32.69 cM) 59581563 
    chicken
    (Gallus gallus)
    Aves HSDL21 hydroxysteroid dehydrogenase like 2 73.04(n)
    73.12(a)
      100858057  XM_003643092.2  XP_003643140.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSDL26
    hydroxysteroid dehydrogenase like 2
    69(a)
    1 ↔ 1
    2(57671954-57709291)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684982 hypothetical protein MGC68498 75.62(n)    BC059996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb58f082 wufb58f08 74.18(n)   322347  BC062838.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55901 CG5590 57.15(n)
    59.8(a)
      43325  NM_143321.3  NP_651578.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-181 dhs-18 60.48(n)
    65.45(a)
      179529  NM_073411.5  NP_505812.1 


    ENSEMBL Gene Tree for HSDL2 (if available)
    TreeFam Gene Tree for HSDL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSDL2 (see all 2089)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs759304131,2
    C,F--115140208(+) CATTTC/TTACTA 3 -- us2k11Minor allele frequency- T:0.01NA 120
    rs49791091,2
    C,F,A,H--115140276(+) AAATGG/ACTTCT 3 -- us2k126Minor allele frequency- A:0.34NS EA NA WA CSA 2563
    rs39834021,2
    C--115140391(+) CCTTC-/CT    
       T
    /TTC
    ACCCA
    5 -- cds1 us2k10--------
    rs3690765761,2
    --115140392(+) CTCCT-/TCCTCACC 5 -- us2k1 cds10--------
    rs725351321,2
    C--115140393(+) TCCTT-/CTC/  
     CTT
    /TTC
    CACCC
    7 -- us2k1 cds11CSA 2
    rs1431905341,2
    --115140458(+) AAGGTA/CATGGG 3 -- us2k10--------
    rs1854529711,2
    --115140500(+) GTCAAA/CGTACT 3 -- us2k10--------
    rs743995221,2
    C,F--115140527(+) AACTTG/CCTTGG 3 -- us2k12Minor allele frequency- C:0.09CSA WA 120
    rs1906589961,2
    --115140531(+) TGCTTA/GGTAAA 3 -- us2k10--------
    rs1814803131,2
    --115140588(+) TCGCAA/CAGTAT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HSDL2 (115142189 - 115234690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HSDL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678312CNV Deletion23128226
    nsv6668CNV Insertion18451855
    nsv6669CNV Insertion18451855
    nsv466487CNV Loss19166990
    nsv511430CNV Loss21212237
    nsv825046CNV Gain20364138
    nsv893732CNV Gain21882294
    dgv1231n67CNV Gain20364138
    esv32838CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    9 diseases for HSDL2:    
    About MalaCards
    cleft lip    atherosclerosis    tonsillitis    tuberculosis
    thyroiditis    cerebritis    malaria    endotheliitis
    prostatitis


    HSDL2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSDL2
    Human Genome Epidemiology (HuGE) Navigator: HSDL2 (2 documents)

    Export disorders for HSDL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSDL2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with HSDL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human hydroxysteroid dehydrogenase-like 2 (HSDL2) cDNA from fetal brain. (PubMed id 12834046)1, 2, 3, 9 Dai J.... Mao Y. (Biochem. Genet. 2003)
    2. In search for function of two human orphan SDR enzymes: Hydroxysteroid dehydrogenase like 2 (HSDL2) and short-chain dehydrogenase/reductase-orphan (SDR-O). (PubMed id 19703561)1, 2, 9 Kowalik D.... Moeller G. (J. Steroid Biochem. Mol. Biol. 2009)
    3. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PubMed id 20583170)1, 4 Letra A....Vieira A.R. (Am. J. Med. Genet. A 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    10. Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (Mol. Endocrinol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84263 HGNC: 18572 AceView: C9orf99 Ensembl:ENSG00000119471 euGenes: HUgn84263
    ECgene: HSDL2 H-InvDB: HSDL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSDL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSDL2 gene:
    Search GeneIP for patents involving HSDL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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