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Aliases for HSDL1 Gene

Aliases for HSDL1 Gene

  • Hydroxysteroid Dehydrogenase Like 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 12C Member 3 3 4
  • SDR12C3 3 4
  • Short Chain Dehydrogenase/Reductase Family 12C, Member 3 3
  • Short Chain Dehydrogenase/Reductase Family 12C 2
  • Steroid Dehydrogenase-Like Protein 3
  • Member 3 2

External Ids for HSDL1 Gene

Previous GeneCards Identifiers for HSDL1 Gene

  • GC16M082714
  • GC16M069909

Summaries for HSDL1 Gene

GeneCards Summary for HSDL1 Gene

HSDL1 (Hydroxysteroid Dehydrogenase Like 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD17B3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSDL1 Gene

Genomics for HSDL1 Gene

Regulatory Elements for HSDL1 Gene

Enhancers for HSDL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSDL1 on UCSC Golden Path with GeneCards custom track

Promoters for HSDL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSDL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSDL1 Gene

Chromosome:
16
Start:
84,122,139 bp from pter
End:
84,145,195 bp from pter
Size:
23,057 bases
Orientation:
Minus strand

Genomic View for HSDL1 Gene

Genes around HSDL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSDL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSDL1 Gene

Proteins for HSDL1 Gene

  • Protein details for HSDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXM5-HSDL1_HUMAN
    Recommended name:
    Inactive hydroxysteroid dehydrogenase-like protein 1
    Protein Accession:
    Q3SXM5
    Secondary Accessions:
    • B4DSL2
    • D3DUL4
    • Q3SXM4
    • Q8NC98
    • Q9BY22

    Protein attributes for HSDL1 Gene

    Size:
    330 amino acids
    Molecular mass:
    37002 Da
    Quaternary structure:
    • Interacts with STYXL1.
    SequenceCaution:
    • Sequence=AAK15047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK16927.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HSDL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSDL1 Gene

Proteomics data for HSDL1 Gene at MOPED

Post-translational modifications for HSDL1 Gene

  • Ubiquitination at Lys 81 and Lys 109
  • Modification sites at PhosphoSitePlus

Other Protein References for HSDL1 Gene

No data available for DME Specific Peptides for HSDL1 Gene

Domains & Families for HSDL1 Gene

Gene Families for HSDL1 Gene

Protein Domains for HSDL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q3SXM5

UniProtKB/Swiss-Prot:

HSDL1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
genes like me logo Genes that share domains with HSDL1: view

Function for HSDL1 Gene

genes like me logo Genes that share phenotypes with HSDL1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSDL1 Gene

Localization for HSDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSDL1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSDL1 Gene COMPARTMENTS Subcellular localization image for HSDL1 gene
Compartment Confidence
mitochondrion 4
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HSDL1 Gene

Pathways & Interactions for HSDL1 Gene

SuperPathways for HSDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSDL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HSDL1 Gene

Drugs & Compounds for HSDL1 Gene

No Compound Related Data Available

Transcripts for HSDL1 Gene

Unigene Clusters for HSDL1 Gene

Hydroxysteroid dehydrogenase like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSDL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - -

Relevant External Links for HSDL1 Gene

GeneLoc Exon Structure for
HSDL1
ECgene alternative splicing isoforms for
HSDL1

Expression for HSDL1 Gene

mRNA expression in normal human tissues for HSDL1 Gene

Protein differential expression in normal tissues from HIPED for HSDL1 Gene

This gene is overexpressed in Breast (35.7) and Fetal Brain (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSDL1 Gene



SOURCE GeneReport for Unigene cluster for HSDL1 Gene Hs.555992

mRNA Expression by UniProt/SwissProt for HSDL1 Gene

Q3SXM5-HSDL1_HUMAN
Tissue specificity: Highly expressed in testis and ovary. Also detected in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas.
genes like me logo Genes that share expression patterns with HSDL1: view

Protein tissue co-expression partners for HSDL1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSDL1 Gene

Orthologs for HSDL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSDL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSDL1 35
  • 85.05 (n)
  • 92.12 (a)
HSDL1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSDL1 35
  • 88.48 (n)
  • 93.03 (a)
HSDL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsdl1 35
  • 81.21 (n)
  • 87.88 (a)
Hsdl1 16
Hsdl1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSDL1 35
  • 99.29 (n)
  • 99.39 (a)
HSDL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsdl1 35
  • 81.41 (n)
  • 86.97 (a)
oppossum
(Monodelphis domestica)
Mammalia HSDL1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSDL1 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSDL1 35
  • 67.98 (n)
  • 65.15 (a)
HSDL1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSDL1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489686 35
  • 58.04 (n)
  • 51.78 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18436 35
hsdl1 35
  • 58.02 (n)
  • 53.48 (a)
hsdl1 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4813 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008570 35
  • 49.6 (n)
  • 43.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31810 35
  • 48.61 (n)
  • 41.47 (a)
CG13284 36
  • 37 (a)
OneToMany
CG31809 36
  • 38 (a)
OneToMany
CG31810 36
  • 38 (a)
OneToMany
CG6012 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-767 36
  • 29 (a)
OneToMany
stdh-1 36
  • 31 (a)
OneToMany
stdh-2 36
  • 31 (a)
OneToMany
stdh-3 36
  • 30 (a)
OneToMany
stdh-4 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IFA38 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons KCR2 35
  • 48.57 (n)
  • 41.79 (a)
rice
(Oryza sativa)
Liliopsida Os11g0432600 35
  • 52.04 (n)
  • 43.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for HSDL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSDL1 Gene

ENSEMBL:
Gene Tree for HSDL1 (if available)
TreeFam:
Gene Tree for HSDL1 (if available)

Paralogs for HSDL1 Gene

Paralogs for HSDL1 Gene

(2) SIMAP similar genes for HSDL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSDL1: view

Variants for HSDL1 Gene

Sequence variations from dbSNP and Humsavar for HSDL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11540436 - 84,129,700(-) TAATC(C/T)CTTTC reference, missense
rs4378600 - 84,124,643(+) TGCAG(C/G)ATAAG reference, missense
rs4082806 -- 84,132,015(-) GCTAC(A/G)GATGT intron-variant
rs4423405 -- 84,142,307(+) CCTTA(G/T)CCTCA intron-variant
rs12935048 -- 84,142,357(+) TTACA(C/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSDL1 Gene

Variant ID Type Subtype PubMed ID
nsv907059 CNV Gain 21882294
nsv833309 CNV Loss 17160897

Variation tolerance for HSDL1 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.52; 82.29% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSDL1 Gene

Disorders for HSDL1 Gene

Relevant External Links for HSDL1

Genetic Association Database (GAD)
HSDL1
Human Genome Epidemiology (HuGE) Navigator
HSDL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSDL1

No disorders were found for HSDL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSDL1 Gene

Publications for HSDL1 Gene

  1. A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues. (PMID: 12153137) Huang Y. … Mao Y. (Mol. Biol. Rep. 2001) 2 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species. (PMID: 19026618) Meier M. … Adamski J. (Chem. Biol. Interact. 2009) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HSDL1 Gene

Sources for HSDL1 Gene

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