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HSDL1 Gene

protein-coding   GIFtS: 50
GCID: GC16M084155

Hydroxysteroid Dehydrogenase Like 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Hydroxysteroid Dehydrogenase Like 11 2     Inactive Hydroxysteroid Dehydrogenase-Like Protein 12
Member 31     Short Chain Dehydrogenase/Reductase Family 12C, Member 32
Short Chain Dehydrogenase/Reductase Family 12C1     Steroid Dehydrogenase-Like Protein2
SDR12C32     

External Ids:    HGNC: 164751   Entrez Gene: 836932   Ensembl: ENSG000001031607   UniProtKB: Q3SXM53   
ORGUL members:         

Export aliases for HSDL1 gene to outside databases

Previous GC identifers: GC16M082714 GC16M069909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSDL1 Gene:
HSDL1 (hydroxysteroid dehydrogenase like 1) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD17B3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSDL1 gene promoter:
         CREB   AP-1   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSDL1 promoter sequence
   Search Chromatin IP Primers for HSDL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSDL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q24

HSDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSDL1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084155:  view genomic region     (about GC identifiers)

Start:
84,155,744 bp from pter      End:
84,178,800 bp from pter
Size:
23,057 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HSDL1_HUMAN, Q3SXM5 (See protein sequence)
Recommended Name: Inactive hydroxysteroid dehydrogenase-like protein 1  
Size: 330 amino acids; 37002 Da
Subunit: Interacts with STYXL1
Caution: Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active
site residue. It is therefore expected that this protein lacks oxidoreductase activity
Sequence caution: Sequence=AAK15047.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAK16927.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DSL2 D3DUL4 Q3SXM4 Q8NC98 Q9BY22
Alternative splicing: 2 isoforms:  Q3SXM5-1   Q3SXM5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HSDL1: NX_Q3SXM5

Explore proteomics data for HSDL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys81, Lys109
  • Modification sites at PhosphoSitePlus

  • See HSDL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139523.1  NP_113651.4  

    ENSEMBL proteins: 
     ENSP00000219439   ENSP00000407437   ENSP00000457026   ENSP00000455797   ENSP00000454856  

    HSDL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HSDL1

     
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    antibodies-online proteins for HSDL1 (6 products) 

     
    antibodies-online peptides for HSDL1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q3SXM5

    ProtoNet protein and cluster: Q3SXM5

    1 Blocks protein domain: IPB002198 Short-chain dehydrogenase/reductase SDR

    UniProtKB/Swiss-Prot: HSDL1_HUMAN, Q3SXM5
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily


    Find genes that share domains with HSDL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016491oxidoreductase activity IEA--
         
    Find genes that share ontologies with HSDL1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HSDL1

    miRNA
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    miRTarBase miRNAs that target HSDL1:
    hsa-mir-455-3p (MIRT037824), hsa-mir-155-5p (MIRT001544), hsa-mir-340-5p (MIRT019573)

    Block miRNA regulation of human, mouse, rat HSDL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSDL1 (see all 23):
    hsa-miR-142-5p hsa-miR-3673 hsa-miR-4251 hsa-miR-539 hsa-miR-340 hsa-miR-103a hsa-miR-155 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidHSDL1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSDL1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSDL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSDL1_HUMAN, Q3SXM5: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with HSDL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSDL1
    Interactions:

        Search GeneGlobe Interaction Network for HSDL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for HSDL1 (Q3SXM53 ENSP000002194394) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PITPNAQ001693, ENSP000003168094I2D: score=1 STRING: ENSP00000316809
    SLC2A4P146723I2D: score=1 
    EIF2B4ENSP000003948694STRING: ENSP00000394869
    EIF2B5ENSP000002737834STRING: ENSP00000273783
    EIF2B2ENSP000002661264STRING: ENSP00000266126
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    Find genes that share ontologies with HSDL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSDL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HSDL1 gene (2 alternative transcripts): 
    NM_001146051.1  NM_031463.4  

    Unigene Cluster for HSDL1:

    Hydroxysteroid dehydrogenase like 1
    Hs.555992  [show with all ESTs]
    Unigene Representative Sequence: NM_031463
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219439(uc010vnv.1 uc002fhk.2) ENST00000565275 ENST00000434463
    ENST00000568857 ENST00000562224 ENST00000567294 ENST00000564998
    miRNA
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    Block miRNA regulation of human, mouse, rat HSDL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HSDL1 (see all 23):
    hsa-miR-142-5p hsa-miR-3673 hsa-miR-4251 hsa-miR-539 hsa-miR-340 hsa-miR-103a hsa-miR-155 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidHSDL1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSDL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSDL1
    Primer
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    OriGene qPCR primer pairs and template standards for HSDL1
    OriGene qSTAR qPCR primer pairs in human, mouse for HSDL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSDL1
      QuantiTect SYBR Green Assays in human, mouse, rat HSDL1
      QuantiFast Probe-based Assays in human, mouse, rat HSDL1

    Additional mRNA sequence: 

    AF237684.1 AK025626.1 AK074878.1 AK299798.1 AY028377.1 BC018084.1 BC104218.1 BC104219.1 
    BC106917.2 

    7 DOTS entries:

    DT.446053  DT.97816995  DT.100750171  DT.86842139  DT.75102092  DT.120706078  DT.120706082 

    Selected AceView cDNA sequences (see all 138):

    Z39917 AF237684 AA306355 AI656912 BC018084 AA243355 BQ650297 F05781 
    BM695170 AK098199 BQ021881 AI264448 AK025626 AY028377 BQ648751 BP359486 
    BQ003335 BU196035 BM553870 AA148728 AV715850 H25167 H40439 AI218459 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HSDL1 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
    SP1:                          -     -                                                                                             
    SP2:                          -                                                                                                   
    SP3:                          -     -                       -                                                                     
    SP4:                          -     -     -                                                                                       
    SP5:                          -     -                             -     -                                                         


    ECgene alternative splicing isoforms for HSDL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSDL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HSDL1 Expression
    About this image

    HSDL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSDL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555992

    UniProtKB/Swiss-Prot: HSDL1_HUMAN, Q3SXM5
    Tissue specificity: Highly expressed in testis and ovary. Also detected in thyroid, spinal cord, adrenal gland,
    heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSDL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSDL1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsdl11 , 5 hydroxysteroid dehydrogenase like 11, 5 81.21(n)1
    87.88(a)1
      8 (67.95 cM)5
    725521  NM_175185.41  NP_780394.11 
     1195619795 
    chicken
    (Gallus gallus)
    Aves HSDL11 hydroxysteroid dehydrogenase like 1 67.98(n)
    65.15(a)
      415703  NM_001005837.1  NP_001005837.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSDL16
    hydroxysteroid dehydrogenase like 1
    60(a)
    1 ↔ 1
    5(108404485-108415304)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004896861 inactive hydroxysteroid dehydrogenase-like protein more 58.04(n)
    51.78(a)
      100489686  XM_002937319.1  XP_002937365.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.184362 Transcribed sequence with weak similarity to protein more 72.72(n)    BQ284448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG318101 CG31810 48.61(n)
    41.47(a)
      318955  NM_165198.2  NP_724023.1 
    worm
    (Caenorhabditis elegans)
    Secernentea stdh-46
    stdh-26
    (see all 5)
    Protein STDH-2 (stdh-2) mRNA, complete cds
    (see all 5)
    36(a)
    31(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    V(8549289-8551165) WBGene00006435
    V(16224334-16225540) WBGene00008678
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IFA386
    Microsomal beta-keto-reductase; contains oleate re...
    26(a)
    1 → many
    II(558685-559728) YBR159W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons KCR21 KCR2 48.57(n)
    41.79(a)
      839063  NM_102292.2  NP_173856.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g04326001 Os11g0432600 52.04(n)
    43.08(a)
      4350399  NM_001074326.1  NP_001067794.1 


    ENSEMBL Gene Tree for HSDL1 (if available)
    TreeFam Gene Tree for HSDL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSDL1 gene
    HSD17B32  HSD17B122  
    2 SIMAP similar genes for HSDL1 using alignment to 5 protein entries:     HSDL1_HUMAN (see all proteins):
    HSD17B12    HSD17B3

    Find genes that share paralogs with HSDL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSDL1 (see all 633)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465197761,2
    --84155275(+) CACGCA/GGCCAG 2 -- ds50010--------
    rs779234061,2
    C--84155311(+) ATTCAC/AGACTG 2 -- ds50012Minor allele frequency- A:0.09CSA WA 120
    rs1846955991,2
    --84155336(+) TTATAC/TTCATT 2 -- ds50010--------
    rs786364831,2
    F--84155394(+) TGAGAC/ATGAGA 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1409032711,2
    --84155402(+) AGACAA/TAAATT 2 -- ds50010--------
    rs761747311,2
    --84155423(+) GGTTTC/TGAGGA 2 -- ds50010--------
    rs1147074571,2
    F--84155431(+) GGACAT/CAACCA 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1165619451,2
    F--84155478(+) AGTAAT/CTGAGG 2 -- ds50011Minor allele frequency- C:0.01WA 118
    rs1381643691,2
    --84155708(+) CAACCC/TAGTAG 2 -- ds50010--------
    rs1868002361,2
    --84155842(+) TCATTA/CCAAAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HSDL1 (84155744 - 84178800 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSDL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833309CNV Loss17160897
    nsv907059CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSDL1
    DNA2.0 Custom Variant and Variant Library Synthesis for HSDL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HSDL1           About GenesLikeMe

    Genetic Association Database (GAD): HSDL1
    Human Genome Epidemiology (HuGE) Navigator: HSDL1 (1 document)

    Export disorders for HSDL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSDL1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with HSDL1)
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    1. A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues. (PubMed id 12153137)1, 2, 3, 9 Huang Y.... Mao Y. (Mol. Biol. Rep. 2001)
    2. Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species. (PubMed id 19026618)1, 2, 9 Meier M.... Adamski J. (Chem. Biol. Interact. 2009)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83693 HGNC: 16475 AceView: LOC83693 Ensembl:ENSG00000103160 euGenes: HUgn83693
    ECgene: HSDL1 H-InvDB: HSDL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSDL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSDL1 gene:
    Search GeneIP for patents involving HSDL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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