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Aliases for HSDL1 Gene

Aliases for HSDL1 Gene

  • Hydroxysteroid Dehydrogenase Like 1 2 3
  • Short Chain Dehydrogenase/Reductase Family 12C Member 3 3 4
  • SDR12C3 3 4
  • Short Chain Dehydrogenase/Reductase Family 12C, Member 3 3
  • Inactive Hydroxysteroid Dehydrogenase-Like Protein 1 3
  • Short Chain Dehydrogenase/Reductase Family 12C 2
  • Steroid Dehydrogenase-Like Protein 3
  • Member 3 2

External Ids for HSDL1 Gene

Previous GeneCards Identifiers for HSDL1 Gene

  • GC16M082714
  • GC16M069909

Summaries for HSDL1 Gene

GeneCards Summary for HSDL1 Gene

HSDL1 (Hydroxysteroid Dehydrogenase Like 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD17B3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSDL1 Gene

Genomics for HSDL1 Gene

Regulatory Elements for HSDL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSDL1 Gene

84,122,139 bp from pter
84,145,195 bp from pter
23,057 bases
Minus strand

Genomic View for HSDL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSDL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSDL1 Gene

Proteins for HSDL1 Gene

  • Protein details for HSDL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Inactive hydroxysteroid dehydrogenase-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DSL2
    • D3DUL4
    • Q3SXM4
    • Q8NC98
    • Q9BY22

    Protein attributes for HSDL1 Gene

    330 amino acids
    Molecular mass:
    37002 Da
    Quaternary structure:
    • Interacts with STYXL1.
    • Sequence=AAK15047.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAK16927.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for HSDL1 Gene


neXtProt entry for HSDL1 Gene

Proteomics data for HSDL1 Gene at MOPED

Post-translational modifications for HSDL1 Gene

  • Ubiquitination at Lys81 and Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for HSDL1 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for HSDL1

No data available for DME Specific Peptides for HSDL1 Gene

Domains for HSDL1 Gene

Gene Families for HSDL1 Gene

  • SDRC3 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

Protein Domains for HSDL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q3SXM5
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
genes like me logo Genes that share domains with HSDL1: view

Function for HSDL1 Gene

Gene Ontology (GO) - Molecular Function for HSDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSDL1: view

Animal Model Products

miRNA for HSDL1 Gene

miRTarBase miRNAs that target HSDL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSDL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSDL1 Gene

Localization for HSDL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSDL1 Gene


Subcellular locations from

Jensen Localization Image for HSDL1 Gene COMPARTMENTS Subcellular localization image for HSDL1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HSDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with HSDL1: view

Pathways for HSDL1 Gene

SuperPathways for HSDL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSDL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSDL1: view

No data available for Pathways by source for HSDL1 Gene

Transcripts for HSDL1 Gene

Unigene Clusters for HSDL1 Gene

Hydroxysteroid dehydrogenase like 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSDL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSDL1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: - - - - -

Relevant External Links for HSDL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSDL1 Gene

mRNA expression in normal human tissues for HSDL1 Gene

Protein differential expression in normal tissues for HSDL1 Gene

This gene is overexpressed in Breast (35.7) and Fetal Brain (12.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSDL1 Gene

SOURCE GeneReport for Unigene cluster for HSDL1 Gene Hs.555992

mRNA Expression by UniProt/SwissProt for HSDL1 Gene

Tissue specificity: Highly expressed in testis and ovary. Also detected in thyroid, spinal cord, adrenal gland, heart, placenta, skeletal muscle, small intestine, colon, spleen, prostate and pancreas.
genes like me logo Genes that share expressions with HSDL1: view

Expression partners for HSDL1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSDL1 Gene

Orthologs for HSDL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSDL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSDL1 35
  • 85.05 (n)
  • 92.12 (a)
HSDL1 36
  • 92 (a)
(Canis familiaris)
Mammalia HSDL1 35
  • 88.48 (n)
  • 93.03 (a)
HSDL1 36
  • 93 (a)
(Mus musculus)
Mammalia Hsdl1 35
  • 81.21 (n)
  • 87.88 (a)
Hsdl1 16
Hsdl1 36
  • 88 (a)
(Pan troglodytes)
Mammalia HSDL1 35
  • 99.29 (n)
  • 99.39 (a)
HSDL1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hsdl1 35
  • 81.41 (n)
  • 86.97 (a)
(Monodelphis domestica)
Mammalia HSDL1 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia HSDL1 36
  • 81 (a)
(Gallus gallus)
Aves HSDL1 35
  • 67.98 (n)
  • 65.15 (a)
HSDL1 36
  • 65 (a)
(Anolis carolinensis)
Reptilia HSDL1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489686 35
  • 58.04 (n)
  • 51.78 (a)
(Danio rerio)
Actinopterygii Dr.18436 35
hsdl1 35
  • 58.02 (n)
  • 53.48 (a)
hsdl1 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4813 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008570 35
  • 49.6 (n)
  • 43.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31810 35
  • 48.61 (n)
  • 41.47 (a)
CG13284 36
  • 37 (a)
CG31809 36
  • 38 (a)
CG31810 36
  • 38 (a)
CG6012 36
  • 34 (a)
(Caenorhabditis elegans)
Secernentea let-767 36
  • 29 (a)
stdh-1 36
  • 31 (a)
stdh-2 36
  • 31 (a)
stdh-3 36
  • 30 (a)
stdh-4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IFA38 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons KCR2 35
  • 48.57 (n)
  • 41.79 (a)
(Oryza sativa)
Liliopsida Os11g0432600 35
  • 52.04 (n)
  • 43.08 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for HSDL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSDL1 Gene

Gene Tree for HSDL1 (if available)
Gene Tree for HSDL1 (if available)

Paralogs for HSDL1 Gene

Paralogs for HSDL1 Gene

Selected SIMAP similar genes for HSDL1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HSDL1: view

Variants for HSDL1 Gene

Sequence variations from dbSNP and Humsavar for HSDL1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1058437 -- 84,123,588(-) GTCAA(A/T)ATAAG utr-variant-3-prime
rs1058438 -- 84,123,454(-) CTTAG(G/T)TTGGG utr-variant-3-prime
rs1058444 -- 84,122,675(-) GGGGT(C/G)TCATT utr-variant-3-prime
rs1364255 -- 84,142,268(-) AAGCA(A/G)AAAGA intron-variant
rs1364256 -- 84,142,165(-) GAATG(A/G)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSDL1 Gene

Variant ID Type Subtype PubMed ID
nsv907059 CNV Gain 21882294
nsv833309 CNV Loss 17160897

Relevant External Links for HSDL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSDL1 Gene

Disorders for HSDL1 Gene

Relevant External Links for HSDL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HSDL1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HSDL1 Gene

Publications for HSDL1 Gene

  1. A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues. (PMID: 12153137) Huang Y. … Mao Y. (Mol. Biol. Rep. 2001) 2 3 4 23
  2. Human and zebrafish hydroxysteroid dehydrogenase like 1 (HSDL1) proteins are inactive enzymes but conserved among species. (PMID: 19026618) Meier M. … Adamski J. (Chem. Biol. Interact. 2009) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for HSDL1 Gene

Sources for HSDL1 Gene

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