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Aliases for HSD17B8 Gene

Aliases for HSD17B8 Gene

  • Hydroxysteroid 17-Beta Dehydrogenase 8 2 3 5
  • 3-Ketoacyl-[Acyl-Carrier-Protein] Reductase Alpha Subunit 3 4
  • Short Chain Dehydrogenase/Reductase Family 30C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase 8 3 4
  • Really Interesting New Gene 2 Protein 3 4
  • Testosterone 17-Beta-Dehydrogenase 8 3 4
  • KAR Alpha Subunit 3 4
  • 17-Beta-HSD 8 3 4
  • Protein Ke6 3 4
  • SDR30C1 3 4
  • FABGL 3 4
  • RING2 3 4
  • Ke-6 3 4
  • HKE6 3 4
  • FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E. Coli) 2
  • Short Chain Dehydrogenase/Reductase Family 30C, Member 1 2
  • Hydroxysteroid (17-Beta) Dehydrogenase 8 2
  • Estradiol 17-Beta-Dehydrogenase 8 3
  • Estrogen 17-Oxidoreductase 3
  • EC 4
  • DJ1033B10.9 3
  • EC 4
  • EC 1.1.1.- 4
  • D6S2245E 3
  • H2-KE6 3
  • FABG 3
  • KE6 3

External Ids for HSD17B8 Gene

Previous HGNC Symbols for HSD17B8 Gene


Previous GeneCards Identifiers for HSD17B8 Gene

  • GC06P033175
  • GC06P033165
  • GC06P033219
  • GC06P033280
  • GC06P033173
  • GC06P032914
  • GC06P033182
  • GC06P033194

Summaries for HSD17B8 Gene

Entrez Gene Summary for HSD17B8 Gene

  • In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSD17B8 Gene

HSD17B8 (Hydroxysteroid 17-Beta Dehydrogenase 8) is a Protein Coding gene. Among its related pathways are Metabolism and Androstenedione and testosterone biosynthesis and metabolism p.1. GO annotations related to this gene include oxidoreductase activity and 3-hydroxyacyl-CoA dehydrogenase activity. An important paralog of this gene is HSD17B10.

UniProtKB/Swiss-Prot for HSD17B8 Gene

  • NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).

Gene Wiki entry for HSD17B8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B8 Gene

Genomics for HSD17B8 Gene

Regulatory Elements for HSD17B8 Gene

Enhancers for HSD17B8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F033016 1.7 FANTOM5 Ensembl ENCODE 15.4 -185.8 -185770 5.0 PKNOX1 ZNF493 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 HCG25 BRD2 VPS52 LEMD2 ATF6B RXRB RING1 PPT2 MIR6873 DAXX
GH06F033160 1.6 FANTOM5 Ensembl ENCODE 15.3 -43.0 -43043 2.0 PKNOX1 CREB3L1 ZFP64 ARID4B DMAP1 ZNF48 ZNF2 GLIS2 ZNF143 SP3 HSD17B8 HCG24 RPS18 HLA-DPB1 HLA-DPB2 COL11A2
GH06F033197 1.3 Ensembl ENCODE 14.7 -6.8 -6770 1.6 HDGF ATF1 MLX ARID4B DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 HSD17B8 COL11A2 GC06P033199
GH06F033061 1.5 FANTOM5 Ensembl ENCODE 11.1 -142.5 -142463 0.7 HDGF TBP ATF1 CBX5 ELK1 ZNF143 ZNF207 CREM SMAD5 CBFB HLA-DPA1 HLA-DQB1 TAP1 PSMB9 RNY4P10 RXRB SLC39A7 HSD17B8 MIR219A1 HLA-DPB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSD17B8 on UCSC Golden Path with GeneCards custom track

Promoters for HSD17B8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001879917 163 801 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the HSD17B8 gene promoter:

Genomic Location for HSD17B8 Gene

33,204,637 bp from pter
33,206,831 bp from pter
2,195 bases
Plus strand

Genomic View for HSD17B8 Gene

Genes around HSD17B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD17B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD17B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSD17B8 Gene

  • Protein details for HSD17B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Estradiol 17-beta-dehydrogenase 8
    Protein Accession:
    Secondary Accessions:
    • A6NLX7
    • Q5STP7
    • Q9UIQ1

    Protein attributes for HSD17B8 Gene

    261 amino acids
    Molecular mass:
    26974 Da
    Quaternary structure:
    • Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for HSD17B8 Gene

neXtProt entry for HSD17B8 Gene

Post-translational modifications for HSD17B8 Gene

  • Ubiquitination at Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for HSD17B8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSD17B8 Gene

Domains & Families for HSD17B8 Gene

Gene Families for HSD17B8 Gene

Suggested Antigen Peptide Sequences for HSD17B8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B8: view

Function for HSD17B8 Gene

Molecular function for HSD17B8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot CatalyticActivity:
Testosterone + NAD(+) = androstenedione + NADH.
UniProtKB/Swiss-Prot Function:
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).
UniProtKB/Swiss-Prot Induction:
Up-regulated by estradiol.

Enzyme Numbers (IUBMB) for HSD17B8 Gene

Gene Ontology (GO) - Molecular Function for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IDA 19571038
GO:0004303 estradiol 17-beta-dehydrogenase activity IEA,IDA 17978863
GO:0005515 protein binding IPI 19571038
GO:0016491 oxidoreductase activity IEA --
GO:0047025 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity IMP 25203508
genes like me logo Genes that share ontologies with HSD17B8: view
genes like me logo Genes that share phenotypes with HSD17B8: view

Animal Model Products

miRNA for HSD17B8 Gene

miRTarBase miRNAs that target HSD17B8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSD17B8 Gene

Localization for HSD17B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B8 Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD17B8 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005740 mitochondrial envelope IEA --
GO:0005759 mitochondrial matrix IEA,IDA 19571038
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

Pathways & Interactions for HSD17B8 Gene

genes like me logo Genes that share pathways with HSD17B8: view

Pathways by source for HSD17B8 Gene

UniProtKB/Swiss-Prot Q92506-DHB8_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.
  • Pathway: Steroid biosynthesis; estrogen biosynthesis.

Gene Ontology (GO) - Biological Process for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IMP 25203508
GO:0006694 steroid biosynthetic process IEA --
GO:0006703 estrogen biosynthetic process IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

No data available for SIGNOR curated interactions for HSD17B8 Gene

Drugs & Compounds for HSD17B8 Gene

(8) Drugs for HSD17B8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational, Vet_approved Pharma Sex hormone 1283
Estriol Approved, Vet_approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 21
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 546
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(8) Additional Compounds for HSD17B8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 11beta-Hydroxyandrost-4-ene-3,17-dione
  • 4-Androsten-11beta-ol-3,17-dione
  • Androst-4-ene-3,17-dione-11beta-ol
  • 16 alpha-Hydroxyestrone
  • 16a-Hydroxyestrone
  • 3,16a-Dihydroxy-1,3,5(10)-estratrien-17-one
  • 3,16a-Dihydroxy-Estra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(10)-triene-3,16a-diol-17-one
  • 16-Hydroxyestrone
  • 16alpha-Hydroxyestrone
  • 16beta-Hydroxyestrone
  • 3,16-Dihydroxy-Estra-1,3,5(10)-trien-17-one
  • 3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with HSD17B8: view

Transcripts for HSD17B8 Gene

mRNA/cDNA for HSD17B8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSD17B8 Gene

Hydroxysteroid (17-beta) dehydrogenase 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B8 Gene

No ASD Table

Relevant External Links for HSD17B8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSD17B8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HSD17B8 Gene

mRNA differential expression in normal tissues according to GTEx for HSD17B8 Gene

This gene is overexpressed in Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HSD17B8 Gene

This gene is overexpressed in Liver (10.1) and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HSD17B8 Gene

Protein tissue co-expression partners for HSD17B8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HSD17B8 Gene:


SOURCE GeneReport for Unigene cluster for HSD17B8 Gene:


mRNA Expression by UniProt/SwissProt for HSD17B8 Gene:

Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.
genes like me logo Genes that share expression patterns with HSD17B8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HSD17B8 Gene

Orthologs for HSD17B8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD17B8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSD17B8 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia HSD17B8 34 35
  • 89.7 (n)
(Bos Taurus)
Mammalia HSD17B8 34 35
  • 88.93 (n)
(Mus musculus)
Mammalia H2-Ke6 34 16 35
  • 87.13 (n)
(Rattus norvegicus)
Mammalia Hsd17b8 34
  • 86.49 (n)
(Monodelphis domestica)
Mammalia HSD17B8 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b8 34
  • 60.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10316 34
(Danio rerio)
Actinopterygii hsd17b8 34 35
  • 60 (n)
fabgl 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14027 34
fruit fly
(Drosophila melanogaster)
Insecta CG3603 36 34 35
  • 55.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009633 34
  • 54.91 (n)
(Caenorhabditis elegans)
Secernentea dhs-25 34 35
  • 53.28 (n)
dhs-11 35
  • 43 (a)
(Oryza sativa)
Liliopsida Os04g0376300 34
  • 51.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
-- 35
  • 36 (a)
Species where no ortholog for HSD17B8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B8 Gene

Gene Tree for HSD17B8 (if available)
Gene Tree for HSD17B8 (if available)

Paralogs for HSD17B8 Gene

Paralogs for HSD17B8 Gene

(6) SIMAP similar genes for HSD17B8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD17B8: view

Variants for HSD17B8 Gene

Sequence variations from dbSNP and Humsavar for HSD17B8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_035844 A breast cancer sample
rs1048780 -- 33,203,064(+) GTCGG(A/G)GACTT upstream-variant-2KB, reference, synonymous-codon
rs1048781 -- 33,203,623(+) AGTGG(A/G)CAGTG upstream-variant-2KB, reference, missense
rs1048782 -- 33,204,325(+) GGTTA(A/G)TTGGT upstream-variant-2KB, utr-variant-3-prime
rs110662 -- 33,205,155(-) AATAT(C/T)AGAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B8 Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV loss 17160897
nsv522719 CNV loss 19592680
nsv1119076 CNV deletion 24896259
nsv1112900 CNV deletion 24896259
nsv1073969 CNV deletion 25765185
dgv10609n54 CNV loss 21841781

Variation tolerance for HSD17B8 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSD17B8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B8 Gene

Disorders for HSD17B8 Gene

Relevant External Links for HSD17B8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HSD17B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSD17B8 Gene

Publications for HSD17B8 Gene

  1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 4 22 64
  2. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PMID: 18852215) Rotinen M. … Villar J. (J. Endocrinol. 2009) 3 4 22 64
  3. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PMID: 17978863) Ohno S. … Nakajin S. (Mol. Cell. Biochem. 2008) 3 4 22 64
  4. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. (PMID: 25203508) Venkatesan R. … Chen Z. (Nat. Commun. 2014) 3 4 64
  5. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PMID: 20214802) Li J. … Hall P. (Breast Cancer Res. 2010) 3 46 64

Products for HSD17B8 Gene

Sources for HSD17B8 Gene

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