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Aliases for HSD17B8 Gene

Aliases for HSD17B8 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 8 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 30C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase 8 3 4
  • Really Interesting New Gene 2 Protein 3 4
  • Testosterone 17-Beta-Dehydrogenase 8 3 4
  • 17-Beta-HSD 8 3 4
  • Protein Ke6 3 4
  • SDR30C1 3 4
  • FABGL 3 4
  • RING2 3 4
  • Ke-6 3 4
  • HKE6 3 4
  • FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E. Coli) 2
  • Short Chain Dehydrogenase/Reductase Family 30C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 30C 2
  • Estrogen 17-Oxidoreductase 3
  • EC 1.1.1.239 4
  • DJ1033B10.9 3
  • EC 1.1.1.62 4
  • EC 1.1.1.- 4
  • Member 1 2
  • D6S2245E 3
  • H2-KE6 3
  • FABG 3
  • KE6 3

External Ids for HSD17B8 Gene

Previous HGNC Symbols for HSD17B8 Gene

  • FABGL

Previous GeneCards Identifiers for HSD17B8 Gene

  • GC06P033175
  • GC06P033165
  • GC06P033219
  • GC06P033280
  • GC06P033173
  • GC06P032914
  • GC06P033182
  • GC06P033194

Summaries for HSD17B8 Gene

Entrez Gene Summary for HSD17B8 Gene

  • In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSD17B8 Gene

HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8) is a Protein Coding gene. Among its related pathways are Metabolism and Steroid hormone biosynthesis. GO annotations related to this gene include oxidoreductase activity and 3-hydroxyacyl-CoA dehydrogenase activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for HSD17B8 Gene

  • NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

Gene Wiki entry for HSD17B8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B8 Gene

Genomics for HSD17B8 Gene

Regulatory Elements for HSD17B8 Gene

Promoters for HSD17B8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSD17B8 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HSD17B8 gene promoter:

Genomic Location for HSD17B8 Gene

Chromosome:
6
Start:
33,204,637 bp from pter
End:
33,206,831 bp from pter
Size:
2,195 bases
Orientation:
Plus strand

Genomic View for HSD17B8 Gene

Genes around HSD17B8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD17B8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD17B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HSD17B8 Gene

  • Protein details for HSD17B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92506-DHB8_HUMAN
    Recommended name:
    Estradiol 17-beta-dehydrogenase 8
    Protein Accession:
    Q92506
    Secondary Accessions:
    • A6NLX7
    • Q5STP7
    • Q9UIQ1

    Protein attributes for HSD17B8 Gene

    Size:
    261 amino acids
    Molecular mass:
    26974 Da
    Quaternary structure:
    • Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for HSD17B8 Gene

neXtProt entry for HSD17B8 Gene

Proteomics data for HSD17B8 Gene at MOPED

Post-translational modifications for HSD17B8 Gene

  • Ubiquitination at Lys 173
  • Modification sites at PhosphoSitePlus

Other Protein References for HSD17B8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSD17B8 Gene

Domains & Families for HSD17B8 Gene

Gene Families for HSD17B8 Gene

Suggested Antigen Peptide Sequences for HSD17B8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92506

UniProtKB/Swiss-Prot:

DHB8_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B8: view

Function for HSD17B8 Gene

Molecular function for HSD17B8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot CatalyticActivity:
Testosterone + NAD(+) = androstenedione + NADH.
UniProtKB/Swiss-Prot Function:
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.
UniProtKB/Swiss-Prot Induction:
Up-regulated by estradiol.

Enzyme Numbers (IUBMB) for HSD17B8 Gene

Gene Ontology (GO) - Molecular Function for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSD17B8: view
genes like me logo Genes that share phenotypes with HSD17B8: view

Animal Model Products

CRISPR Products

miRNA for HSD17B8 Gene

miRTarBase miRNAs that target HSD17B8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSD17B8 Gene

Localization for HSD17B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B8 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSD17B8 Gene COMPARTMENTS Subcellular localization image for HSD17B8 gene
Compartment Confidence
mitochondrion 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

Pathways & Interactions for HSD17B8 Gene

genes like me logo Genes that share pathways with HSD17B8: view

Pathways by source for HSD17B8 Gene

UniProtKB/Swiss-Prot Q92506-DHB8_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.
  • Pathway: Steroid biosynthesis; estrogen biosynthesis.

Interacting Proteins for HSD17B8 Gene

Gene Ontology (GO) - Biological Process for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006703 estrogen biosynthetic process IEA --
GO:0008152 metabolic process IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

No data available for SIGNOR curated interactions for HSD17B8 Gene

Drugs & Compounds for HSD17B8 Gene

(8) Drugs for HSD17B8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Sex hormone 1094
Estriol Approved Pharma Agonist 0
Estrone Approved Pharma Agonist Estrogenic hormone 19
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 474
2'-Monophosphoadenosine 5'-Diphosphoribose Experimental Pharma Target 0

(8) Additional Compounds for HSD17B8 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11beta,17beta-Dihydroxy-4-androsten-3-one
11b-Hydroxyandrost-4-ene-3,17-dione
  • 11beta-Hydroxyandrost-4-ene-3,17-dione
  • 4-Androsten-11beta-ol-3,17-dione
  • Androst-4-ene-3,17-dione-11beta-ol
382-44-5
16a-Hydroxyestrone
  • 16 alpha-Hydroxyestrone
  • 16a-Hydroxyestrone
  • 3,16a-Dihydroxy-1,3,5(10)-estratrien-17-one
  • 3,16a-Dihydroxy-Estra-1,3,5(10)-trien-17-one
  • Estra-1,3,5(10)-triene-3,16a-diol-17-one
566-76-7
16b-Hydroxyestrone
  • 16-Hydroxyestrone
  • 16alpha-Hydroxyestrone
  • 16beta-Hydroxyestrone
  • 3,16-Dihydroxy-Estra-1,3,5(10)-trien-17-one
  • 3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
966-06-3
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
genes like me logo Genes that share compounds with HSD17B8: view

Transcripts for HSD17B8 Gene

mRNA/cDNA for HSD17B8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSD17B8 Gene

Hydroxysteroid (17-beta) dehydrogenase 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B8 Gene

No ASD Table

Relevant External Links for HSD17B8 Gene

GeneLoc Exon Structure for
HSD17B8
ECgene alternative splicing isoforms for
HSD17B8

Expression for HSD17B8 Gene

mRNA expression in normal human tissues for HSD17B8 Gene

mRNA differential expression in normal tissues according to GTEx for HSD17B8 Gene

This gene is overexpressed in Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HSD17B8 Gene

This gene is overexpressed in Liver (10.1) and Salivary gland (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSD17B8 Gene



SOURCE GeneReport for Unigene cluster for HSD17B8 Gene Hs.415058

mRNA Expression by UniProt/SwissProt for HSD17B8 Gene

Q92506-DHB8_HUMAN
Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.
genes like me logo Genes that share expression patterns with HSD17B8: view

Protein tissue co-expression partners for HSD17B8 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HSD17B8 Gene

Orthologs for HSD17B8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD17B8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSD17B8 35
  • 88.93 (n)
  • 88.42 (a)
HSD17B8 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSD17B8 35
  • 89.7 (n)
  • 88.8 (a)
HSD17B8 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Ke6 35
  • 87.13 (n)
  • 87.64 (a)
H2-Ke6 16
H2-Ke6 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSD17B8 35
  • 99.62 (n)
  • 100 (a)
HSD17B8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsd17b8 35
  • 86.49 (n)
  • 87.64 (a)
oppossum
(Monodelphis domestica)
Mammalia HSD17B8 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b8 35
  • 60.24 (n)
  • 62.65 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10316 35
zebrafish
(Danio rerio)
Actinopterygii fabgl 35
hsd17b8 35
  • 60 (n)
  • 62 (a)
hsd17b8 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14027 35
fruit fly
(Drosophila melanogaster)
Insecta CG3603 37
  • 50 (a)
CG3603 35
  • 55.23 (n)
  • 52.48 (a)
CG3603 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009633 35
  • 54.91 (n)
  • 53.53 (a)
worm
(Caenorhabditis elegans)
Secernentea dhs-25 35
  • 53.28 (n)
  • 51.88 (a)
dhs-11 36
  • 43 (a)
OneToMany
dhs-25 36
  • 50 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os04g0376300 35
  • 51.23 (n)
  • 48.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
Species with no ortholog for HSD17B8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B8 Gene

ENSEMBL:
Gene Tree for HSD17B8 (if available)
TreeFam:
Gene Tree for HSD17B8 (if available)

Paralogs for HSD17B8 Gene

Paralogs for HSD17B8 Gene

(6) SIMAP similar genes for HSD17B8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD17B8: view

Variants for HSD17B8 Gene

Sequence variations from dbSNP and Humsavar for HSD17B8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_035844 A breast cancer sample
rs34491699 - 33,205,830(+) CAGAC(A/G)TGGGA reference, missense
rs110662 -- 33,205,155(-) AATAT(C/T)AGAGC intron-variant
rs365339 -- 33,205,128(-) GGCCT(A/G)GCGTT intron-variant
rs113117452 -- 33,205,738(+) AGATG(C/G)TTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B8 Gene

Variant ID Type Subtype PubMed ID
nsv885768 CNV Loss 21882294
nsv830634 CNV Loss 17160897
nsv522719 CNV Loss 19592680

Variation tolerance for HSD17B8 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSD17B8 Gene

HapMap Linkage Disequilibrium report
HSD17B8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B8 Gene

Disorders for HSD17B8 Gene

Relevant External Links for HSD17B8

Genetic Association Database (GAD)
HSD17B8
Human Genome Epidemiology (HuGE) Navigator
HSD17B8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSD17B8

No disorders were found for HSD17B8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSD17B8 Gene

Publications for HSD17B8 Gene

  1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 4 23 67
  2. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3
  3. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PMID: 18852215) Rotinen M. … Villar J. (J. Endocrinol. 2009) 3 23
  4. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PMID: 17978863) Ohno S. … Nakajin S. (Mol. Cell. Biochem. 2008) 3 23
  5. Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. (PMID: 9205114) Kikuti Y.Y. … Inoko H. (Genomics 1997) 3 23

Products for HSD17B8 Gene

Sources for HSD17B8 Gene

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