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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSD17B8 Gene

protein-coding   GIFtS: 61
GCID: GC06P033194

Hydroxysteroid (17-Beta) Dehydrogenase 8

(Previous names: FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E...)
(Previous symbol: FABGL)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 81 2     FABG2
FABGL1 2 3 5     H2-KE62
HKE62 3 5     KE62
Protein Ke62 3     SDR30C12
Really Interesting New Gene 2 Protein2 3     dJ1033B10.92
Testosterone 17-Beta-Dehydrogenase 82 3     Estradiol 17-Beta-Dehydrogenase 82
17-Beta-HSD 82 3     Estrogen 17-Oxidoreductase2
17-Beta-Hydroxysteroid Dehydrogenase 82 3     ke-62
3-Oxoacyl-[Acyl-Carrier-Protein] Reductase2 3     Short Chain Dehydrogenase/Reductase Family 30C, Member 12
RING22 3     EC 1.1.1.-3
D6S2245E2 5     EC 1.1.1.2393
FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E.
Coli)1
     EC 1.1.1.623
Member 11     Ke-63
Short Chain Dehydrogenase/Reductase Family 30C1     

External Ids:    HGNC: 35541   Entrez Gene: 79232   Ensembl: ENSG000002042287   OMIM: 6014175   UniProtKB: Q925063   

Export aliases for HSD17B8 gene to outside databases

Previous GC identifers: GC06P033175 GC06P033165 GC06P033219 GC06P033280 GC06P033173 GC06P032914 GC06P033182


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSD17B8 Gene:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of
biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol,
testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize
estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain
dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the
full-length nature of this variant has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HSD17B8 Gene: 
HSD17B8 (hydroxysteroid (17-beta) dehydrogenase 8) is a protein-coding gene. Diseases associated with HSD17B8 include polycystic kidney disease, and kidney disease, and among its related super-pathways are Androstenedione and testosterone biosynthesis and metabolism p.1 and Metabolism. GO annotations related to this gene include 3-hydroxyacyl-CoA dehydrogenase activity and nucleotide binding. An important paralog of this gene is HPGD.

UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low
activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein
reductase activity. May play a role in biosynthesis of fatty acids in mitochondria

Gene Wiki entry for HSD17B8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSD17B8 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD17B8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSD17B8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HSD17B8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033194:  view genomic region     (about GC identifiers)

Start:
33,172,419 bp from pter      End:
33,174,608 bp from pter
Size:
2,190 bases      Orientation:
plus strand

5 alternative locations:
Chr6+,NT_167246 4,629,735-4,631,927      Chr6+,NT_113891.2 4,616,253-4,618,437      Chr6+,NT_167245 4,453,726-4,455,914     
Chr6+,NT_167247 4,646,180-4,648,368      Chr6+,NT_167248 4,404,642-4,406,834     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506 (See protein sequence)
Recommended Name: Estradiol 17-beta-dehydrogenase 8  
Size: 261 amino acids; 26974 Da
Subunit: Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4
Subcellular location: Mitochondrion matrix
1 PDB 3D structure from and Proteopedia for HSD17B8:
2PD6 (3D)    
Secondary accessions: A6NLX7 Q5STP7 Q9UIQ1

Explore the universe of human proteins at neXtProt for HSD17B8: NX_Q92506

Explore proteomics data for HSD17B8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92506

  • HSD17B8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSD17B8 Protein Expression
    REFSEQ proteins: NP_055049.1  
    ENSEMBL proteins: 
     ENSP00000363794  

    Human Recombinant Protein Products for HSD17B8: 
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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005740mitochondrial envelope IEA--
    GO:0005759mitochondrial matrix IDA19571038
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    HSD17B8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC1: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

    4 InterPro protein domains:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q92506

    ProtoNet protein and cluster: Q92506

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    HSD17B8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHB8_HUMAN, Q92506
    Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low
    activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein
    reductase activity. May play a role in biosynthesis of fatty acids in mitochondria
    Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
    Catalytic activity: Testosterone + NAD(+) = androstenedione + NADH
    Induction: Up-regulated by estradiol

         Enzyme Numbers (IUBMB): EC 1.1.1.621 EC 1.1.1.2391 EC 1.1.1.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00038573-hydroxyacyl-CoA dehydrogenase activity IDA19571038
    GO:0004303estradiol 17-beta-dehydrogenase activity IDA17978863
    GO:0005515protein binding IPI19571038
    GO:0016491oxidoreductase activity ----
    GO:0047035testosterone dehydrogenase (NAD+) activity IEA--
         
    HSD17B8 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSD17B8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Estrone metabolism
    Estrone metabolism0.57
    Estrogen biosynthesis0.47
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    2Metabolism
    Metabolic pathways0.40
    3Glucuronidation
    Steroid hormone biosynthesis0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HSD17B8
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estrone metabolism
    Estrogen biosynthesis


    3 GeneGo (Thomson Reuters) Pathways for HSD17B8
        Estrogen biosynthesis
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1



    2         Kegg Pathways  (Kegg details for HSD17B8):
        Steroid hormone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Pathway: Steroid biosynthesis; estrogen biosynthesis
    Pathway: Lipid metabolism; fatty acid biosynthesis


    HSD17B8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSD17B8

    1 Interacting protein for HSD17B8 (Q925063) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006703estrogen biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0008209androgen metabolic process IEA--
    GO:0008210estrogen metabolic process ----

    HSD17B8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSD17B8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HSD17B8 (DHB8)

    9 HMDB Compounds for HSD17B8    About this table
    CompoundSynonyms CAS #PubMed Ids
    16a-Hydroxyestrone16a-Hydroxyestrone (see all 5)566-76-7--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estriol13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol (see all 50)50-27-1--
    Estrone(+)-Estrone (see all 7)53-16-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    2 DrugBank Compounds for HSD17B8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235

    1 Novoseek inferred chemical compound relationship for HSD17B8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 23.5 2 8812499 (1), 9205114 (1)

    Search CenterWatch for drugs/clinical trials and news about HSD17B8 / DHB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSD17B8 gene: 
    NM_014234.4  

    Unigene Cluster for HSD17B8:

    Hydroxysteroid (17-beta) dehydrogenase 8
    Hs.415058  [show with all ESTs]
    Unigene Representative Sequence: BQ651523
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374662(uc003odi.1) ENST00000469186
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    BC008185.1 BT007239.1 D82061.1 

    4 DOTS entries:

    DT.100699398  DT.86841171  DT.211216  DT.95255443 

    24/365 AceView cDNA sequences (see all 365):

    BP341645 AW134912 W69711 BM930709 BU688905 AW950194 CR597948 CA454113 
    BM460286 AA301545 AA918575 CB135931 CR622526 H84574 BX095962 BM757480 
    BM761424 AA319058 BM707640 BM717786 BP365155 BI763892 BE275203 BM843446 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSD17B8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTGCCTC
    HSD17B8 Expression
    About this image


    See HSD17B8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSD17B8

    SOURCE GeneReport for Unigene cluster: Hs.415058

    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney.
    Widely expressed

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSD17B8 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Ke61 , 5 H2-K region expressed gene 61, 5 87.13(n)1
    87.64(a)1
      17 (17.98 cM)5
    149791  NM_013543.21  NP_038571.21 
     340260335 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.103162 Xenopus laevis transcribed sequence with weak similarity more 72.91(n)    BX844609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fabgl2 FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, more 71.15(n)   64815  AF137536.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36031 , 3 oxidoreductase, acting on CH-OH group
    of donors3
    CG36031
    50(a)3
    55.23(n)1
    52.48(a)1
      3C33
    312891  NM_130690.21  NP_570046.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-111 Protein DHS-11 54.32(n)
    51.85(a)
      176485  NM_066945.1  NP_499346.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YMR226C6
    NADP(+)-dependent dehydrogenase; acts on serine, L...
    19(a)
    1 → many
    XIII(721593-722396)
    rice
    (Oryza sativa)
    Liliopsida Os04g03763001 hypothetical protein 51.23(n)
    48.77(a)
      4335609  NM_001059115.1  NP_001052580.1 


    ENSEMBL Gene Tree for HSD17B8 (if available)
    TreeFam Gene Tree for HSD17B8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSD17B8 gene
    HPGD2  DCXR2  DECR22  CBR42  PECR2  HSD17B142  DHRS22  HSD17B102  
    DHRS42  BDH22  DHRS4L22  DECR12  
    7 SIMAP similar genes for HSD17B8 using alignment to 1 protein entry:     DHB8_HUMAN:
    CBR4    HADH2    HSD17B10    DCXR    DHRS4    BDH2
    HSD17B4

    HSD17B8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/35 SNPs in HSD17B8 are shown (see all 35)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358444
    A breast cancer sample4--see VAR_0358442 V L mis40--------
    rs1114933531,2
    C--33172755(+) GACCTG/AGACCG 2 /L syn11Minor allele frequency- A:0.50CSA 2
    rs3653391,2
    C,F,A,H--33172905(-) GGCCTG/AGCGTT 1 -- int121Minor allele frequency- A:0.17EA NA NS WA CSA EU 2071
    rs3765906831,2
    C,F--33172905(+) AACGC-/C/TAGGCC 1 -- int13NA EA 362
    rs1106621,2
    C,F,A,H--33172932(-) AATATT/CAGAGC 1 -- int125Minor allele frequency- C:0.15NA EA MN NS WA CSA 2767
    rs1919651951,2
    C--33172995(+) TCCCAC/TAGGCC 1 -- int10--------
    rs1383524491,2
    C--33173025(+) CTGTC-/GTTGTGTC 1 -- cds10--------
    rs1444572041,2
    F--33173038(+) CTGTGC/TGGGCA 2 A V mis11Minor allele frequency- T:0.00NA 4542
    rs1837284881,2
    --33173110(+) CAACCA/TCAAGG 2 H L mis10--------
    rs1451221171,2
    C--33173119(+) GGTGGC/TGATCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSD17B8 (33172419 - 33174608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HSD17B8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885768CNV Loss21882294
    nsv830634CNV Loss17160897
    nsv522719CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601417    OMIM disorders: --

    8 diseases for HSD17B8:    About MalaCards
    polycystic kidney disease    kidney disease    pneumonia    systemic lupus erythematosus
    tuberculosis    lupus erythematosus    colorectal cancer    breast cancer


    HSD17B8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSD17B8
    Human Genome Epidemiology (HuGE) Navigator: HSD17B8 (9 documents)

    Export disorders for HSD17B8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSD17B8 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HSD17B8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PubMed id 8812499)1, 2, 3, 9 Ando A.... Inoko H. (1996)
    2. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PubMed id 18852215)1, 2, 9 Rotinen M.... Villar J. (2009)
    3. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PubMed id 17978863)1, 2, 9 Ohno S.... Nakajin S. (2008)
    4. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. Genetic variation in the estrogen metabolic pathway a nd mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1, 4 Li J....Hall P. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. (PubMed id 19571038)1, 2 Chen Z.... Hiltunen J.K. (2009)
    9. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    10. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7923 HGNC: 3554 AceView: SLC39A7andHSD17B8 Ensembl:ENSG00000204228 euGenes: HUgn7923
    ECgene: HSD17B8 Kegg: 7923 H-InvDB: HSD17B8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSD17B8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSD17B8 gene:
    Search GeneIP for patents involving HSD17B8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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