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Aliases for HSD17B8 Gene

Aliases for HSD17B8 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 8 2 3
  • FABGL 3 4 6
  • HKE6 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 30C Member 1 3 4
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Reductase 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase 8 3 4
  • Really Interesting New Gene 2 Protein 3 4
  • Testosterone 17-Beta-Dehydrogenase 8 3 4
  • 17-Beta-HSD 8 3 4
  • Protein Ke6 3 4
  • D6S2245E 3 6
  • SDR30C1 3 4
  • RING2 3 4
  • Ke-6 3 4
  • FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E. Coli) 2
  • Short Chain Dehydrogenase/Reductase Family 30C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 30C 2
  • Estradiol 17-Beta-Dehydrogenase 8 3
  • Estrogen 17-Oxidoreductase 3
  • EC 1.1.1.239 4
  • DJ1033B10.9 3
  • EC 1.1.1.62 4
  • EC 1.1.1.- 4
  • Member 1 2
  • H2-KE6 3
  • FABG 3
  • KE6 3

External Ids for HSD17B8 Gene

Previous Symbols for HSD17B8 Gene

  • FABGL

Summaries for HSD17B8 Gene

Entrez Gene Summary for HSD17B8 Gene

  • In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HSD17B8 Gene

HSD17B8 (Hydroxysteroid (17-Beta) Dehydrogenase 8) is a Protein Coding gene. Diseases associated with HSD17B8 include colorectal cancer. Among its related pathways are Metabolism and Steroid hormone biosynthesis. GO annotations related to this gene include estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for HSD17B8 Gene

  • NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.

Gene Wiki entry for HSD17B8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B8 Gene

Genomics for HSD17B8 Gene

Genomic Location for HSD17B8 Gene

Start:
33,204,637 bp from pter
End:
33,206,831 bp from pter
Size:
2,195 bases
Orientation:
Plus strand

Genomic View for HSD17B8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD17B8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HSD17B8 Gene

Transcription factor binding sites by QIAGEN in the HSD17B8 gene promoter:

Proteins for HSD17B8 Gene

  • Protein details for HSD17B8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92506-DHB8_HUMAN
    Recommended name:
    Estradiol 17-beta-dehydrogenase 8
    Protein Accession:
    Q92506
    Secondary Accessions:
    • A6NLX7
    • Q5STP7
    • Q9UIQ1

    Protein attributes for HSD17B8 Gene

    Size:
    261 amino acids
    Molecular mass:
    26974 Da
    Quaternary structure:
    • Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4.

    Three dimensional structures from OCA and Proteopedia for HSD17B8 Gene

neXtProt entry for HSD17B8 Gene

Proteomics data for HSD17B8 Gene at MOPED

Post-translational modifications for HSD17B8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys173

Other Protein References for HSD17B8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSD17B8 Gene

Domains for HSD17B8 Gene

Gene Families for HSD17B8 Gene

HGNC:
  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

UniProtKB/Swiss-Prot:

DHB8_HUMAN
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.:
    • Q92506
genes like me logo Genes that share domains with HSD17B8: view

Function for HSD17B8 Gene

Molecular function for HSD17B8 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
UniProtKB/Swiss-Prot CatalyticActivity: Testosterone + NAD(+) = androstenedione + NADH
UniProtKB/Swiss-Prot Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.
UniProtKB/Swiss-Prot Induction: Up-regulated by estradiol.

Enzyme Numbers (IUBMB) for HSD17B8 Gene

Gene Ontology (GO) - Molecular Function for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity IDA 19571038
GO:0004303 estradiol 17-beta-dehydrogenase activity IDA 17978863
GO:0005515 protein binding IPI 19571038
GO:0016491 oxidoreductase activity --
GO:0047035 testosterone dehydrogenase (NAD+) activity IEA --
genes like me logo Genes that share ontologies with HSD17B8: view

miRNA for HSD17B8 Gene

miRTarBase miRNAs that target HSD17B8

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSD17B8 Gene

Localization for HSD17B8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B8 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSD17B8 Gene COMPARTMENTS Subcellular localization image for HSD17B8 gene
Compartment Confidence
mitochondrion 5
cytosol 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005740 mitochondrial envelope IEA --
GO:0005759 mitochondrial matrix IDA 19571038
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HSD17B8: view

Pathways for HSD17B8 Gene

genes like me logo Genes that share pathways with HSD17B8: view

Pathways by source for HSD17B8 Gene

3 GeneGo (Thomson Reuters Life Sciences Research) pathways for HSD17B8 Gene
2 KEGG pathways for HSD17B8 Gene

UniProtKB/Swiss-Prot Q92506-DHB8_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis
  • Pathway: Steroid biosynthesis; estrogen biosynthesis

Interacting Proteins for HSD17B8 Gene

Gene Ontology (GO) - Biological Process for HSD17B8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006703 estrogen biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0008209 androgen metabolic process IEA --
GO:0008210 estrogen metabolic process --
genes like me logo Genes that share ontologies with HSD17B8: view

Compounds for HSD17B8 Gene

(9) HMDB Compounds for HSD17B8 Gene

Compound Synonyms Cas Number PubMed IDs
16a-Hydroxyestrone
  • 16a-Hydroxyestrone
566-76-7
Estradiol
  • (+)-3,17b-Estradiol
50-28-2
Estriol
  • 13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol
50-27-1
Estrone
  • (+)-Estrone
53-16-7
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9

(2) Drugbank Compounds for HSD17B8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Monophosphoadenosine 5'-Diphosphoribose
target
NADH
  • beta-DPNH
606-68-8 target

(1) Novoseek inferred chemical compound relationships for HSD17B8 Gene

Compound -log(P) Hits PubMed IDs
steroid 23.5 2
genes like me logo Genes that share compounds with HSD17B8: view

Transcripts for HSD17B8 Gene

mRNA/cDNA for HSD17B8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(365) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HSD17B8 Gene

Hydroxysteroid (17-beta) dehydrogenase 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B8 Gene

No ASD Table

Relevant External Links for HSD17B8 Gene

GeneLoc Exon Structure for
HSD17B8
ECgene alternative splicing isoforms for
HSD17B8

Expression for HSD17B8 Gene

mRNA expression in normal human tissues for HSD17B8 Gene

mRNA differential expression in normal tissues according to GTEx for HSD17B8 Gene

This gene is overexpressed in Pancreas (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSD17B8 Gene

SOURCE GeneReport for Unigene cluster for HSD17B8 Gene Hs.415058

mRNA Expression by UniProt/SwissProt for HSD17B8 Gene

Q92506-DHB8_HUMAN
Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely expressed.
genes like me logo Genes that share expressions with HSD17B8: view

Orthologs for HSD17B8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD17B8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSD17B8 36
  • 99.62 (n)
  • 100 (a)
HSD17B8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSD17B8 36
  • 88.93 (n)
  • 88.42 (a)
HSD17B8 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSD17B8 36
  • 89.7 (n)
  • 88.8 (a)
HSD17B8 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Ke6 36
  • 87.13 (n)
  • 87.64 (a)
H2-Ke6 16
H2-Ke6 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSD17B8 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsd17b8 36
  • 86.49 (n)
  • 87.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10316 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b8 36
  • 60.24 (n)
  • 62.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14027 36
zebrafish
(Danio rerio)
Actinopterygii fabgl 36
hsd17b8 36
  • 60 (n)
  • 62 (a)
hsd17b8 37
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009633 36
  • 54.91 (n)
  • 53.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3603 36
  • 55.23 (n)
  • 52.48 (a)
CG3603 37
  • 51 (a)
OneToOne
CG3603 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea dhs-11 37
  • 43 (a)
OneToMany
dhs-25 36
  • 53.28 (n)
  • 51.88 (a)
dhs-25 37
  • 50 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os04g0376300 36
  • 51.23 (n)
  • 48.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
-- 37
  • 46 (a)
OneToMany
Species with no ortholog for HSD17B8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B8 Gene

ENSEMBL:
Gene Tree for HSD17B8 (if available)
TreeFam:
Gene Tree for HSD17B8 (if available)

Paralogs for HSD17B8 Gene

Paralogs for HSD17B8 Gene

Selected SIMAP similar genes for HSD17B8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD17B8: view

Variants for HSD17B8 Gene

Sequence variations from dbSNP and Humsavar for HSD17B8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs110662 -- 33,205,155(-) AATAT(C/T)AGAGC intron-variant
rs365339 -- 33,205,128(-) GGCCT(A/G)GCGTT intron-variant
rs34491699 - 33,205,830(+) CAGAC(A/G)TGGGA reference, missense
rs111231091 -- 33,205,330(+) TGTCA(A/G)CCTCA reference, missense
rs111493353 -- 33,204,978(+) GACCT(A/G)GACCG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for HSD17B8 Gene

Variant ID Type Subtype PubMed ID
nsv885768 CNV Loss 21882294
nsv830634 CNV Loss 17160897
nsv522719 CNV Loss 19592680

Relevant External Links for HSD17B8 Gene

HapMap Linkage Disequilibrium report
HSD17B8

Disorders for HSD17B8 Gene

(1) MalaCards Diseases for HSD17B8 Gene

Search for HSD17B8 Gene in MalaCards »

Relevant External Links for HSD17B8

Genetic Association Database (GAD)
HSD17B8
Human Genome Epidemiology (HuGE) Navigator
HSD17B8
genes like me logo Genes that share disorders with HSD17B8: view

No data available for UniProtKB/Swiss-Prot for HSD17B8 Gene

Publications for HSD17B8 Gene

  1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PMID: 8812499) Ando A. … Inoko H. (Genomics 1996) 2 3 4 23
  2. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PMID: 17978863) Ohno S. … Nakajin S. (Mol. Cell. Biochem. 2008) 3 4 23
  3. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PMID: 18852215) Rotinen M. … Villar J. (J. Endocrinol. 2009) 3 4 23
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HSD17B8 Gene

Sources for HSD17B8 Gene

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