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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSD17B8 Gene

protein-coding   GIFtS: 56
GCID: GC06P033182

hydroxysteroid (17-beta) dehydrogenase 8

(Previous names: FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E...)
(Previous symbol: FABGL)
 Explore 10 diseases affiliated with
HSD17B8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HSD17B8    

Aliases
for HSD17B8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 81 2     3-Oxoacyl-[Acyl-Carrier-Protein] Reductase2 3
FABGL1 2 3 5     FabG (Beta-Ketoacyl-[Acyl-Carrier-Protein] Reductase, E Coli) Like (E. Coli)1
HKE61 2 3 5     FABG2
RING21 2 3     DJ1033B10.91
D6S2245E1 2 5     Estradiol 17-Beta-Dehydrogenase 82
H2-KE61 2     Estrogen 17-Oxidoreductase2
KE61 2     Ke-63
SDR30C11 2     Short Chain Dehydrogenase/Reductase Family 30C, Member 12
Protein Ke62 3     EC 1.1.1.-3
Really Interesting New Gene 2 Protein2 3     EC 1.1.1.2393
Testosterone 17-Beta-Dehydrogenase 82 3     EC 1.1.1.623
17-Beta-HSD 82 3     Ke-63
17-Beta-Hydroxysteroid Dehydrogenase 82 3     

External Ids:    HGNC: 35541   Entrez Gene: 79232   Ensembl: ENSG000002042287   OMIM: 6014175   UniProtKB: Q925063   

Export aliases for HSD17B8 gene to outside databases

Previous GC identifers: GC06P033175 GC06P033165 GC06P033219 GC06P033280 GC06P033173 GC06P032914


Summaries
for HSD17B8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HSD17B8:
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically
active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and
dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The
protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An
alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not
been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low
activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein
reductase activity. May play a role in biosynthesis of fatty acids in mitochondria

Gene Wiki entry for HSD17B8


Genomic Views
for HSD17B8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSD17B8 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSD17B8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSD17B8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HSD17B8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033182:  view genomic region     (about GC identifiers)

Start:
 33,172,419 bp from pter      End:
 33,174,608 bp from pter
Size:
 2,190 bases      Orientation:
 plus strand

5 alternative locations:
Chr6+,ALT_REF_LOCI_2 33,094,049-33,135,421      Chr6+,ALT_REF_LOCI_5 33,257,603-33,259,791      Chr6+,ALT_REF_LOCI_4 33,249,394-33,251,586     
Chr6+,ALT_REF_LOCI_3 33,150,329-33,163,555      Chr6+,ALT_REF_LOCI_6 33,101,245-33,139,018     

Proteins
for HSD17B8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506 (See protein sequence)
Recommended Name: Estradiol 17-beta-dehydrogenase 8  
Size: 261 amino acids; 26974 Da
Subunit: Heterotetramer with CBR4; contains two molecules of HSD17B8 and CBR4
Subcellular location: Mitochondrion matrix
1 PDB 3D structure from and Proteopedia for HSD17B8:
2PD6 (3D)    
Secondary accessions: A6NLX7 Q5STP7 Q9UIQ1

Explore the universe of human proteins at neXtProt for HSD17B8: NX_Q92506

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92506

    • HSD17B8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055049.1  
    ENSEMBL proteins: 
     ENSP00000363794  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005739mitochondrion ----
    GO:0005740mitochondrial envelope IEA--
    GO:0005759mitochondrial matrix IDA19571038
    GO:0005886plasma membrane IEA--


    HSD17B8 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for HSD17B8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HSD17B8 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q92506

    ProtoNet protein and cluster: Q92506

    2 Blocks protein families:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    Function
    for HSD17B8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Function: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low
    activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein
    reductase activity. May play a role in biosynthesis of fatty acids in mitochondria
    Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
    Catalytic activity: Testosterone + NAD(+) = androstenedione + NADH
    Induction: Up-regulated by estradiol

    Enzyme Numbers (IUBMB): EC 1.1.1.621 EC 1.1.1.2391 EC 1.1.1.-1

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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:00038573-hydroxyacyl-CoA dehydrogenase activity IDA19571038
    GO:0004303estradiol 17-beta-dehydrogenase activity IDA17978863
    GO:0005515protein binding IPI19571038
    GO:0047035testosterone dehydrogenase (NAD+) activity IEA--


    HSD17B8 for ontologies           About GeneDecksing



    Pathways & Interactions
    for HSD17B8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Estrone metabolism
    		Estrone metabolism1.00
    		Androstenedione and testosterone biosynthesis and metabolism p.10.57
    		Estrone metabolism1.00
    		Estrogen biosynthesis0.47
    		Androstenedione and testosterone biosynthesis and metabolism p.10.57
    		Estrogen biosynthesis0.47
    2Steroid hormone biosynthesis
    		Steroid hormone biosynthesis1.00
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HSD17B8
        Androstenedione and testosterone biosynthesis and metabolism p.1
    Estrone metabolism
    Estrogen biosynthesis


    3 GeneGo (Thomson Reuters) Pathways for HSD17B8
        Estrogen biosynthesis
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1


    2         Kegg Pathways  (Kegg details for HSD17B8):
        Steroid hormone biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Pathway: Steroid biosynthesis; estrogen biosynthesis
    Pathway: Lipid metabolism; fatty acid biosynthesis


    HSD17B8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSD17B8

    1 Interacting protein for HSD17B8 (Q925063) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A4P146723I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006703estrogen biosynthetic process IEA--
    GO:0008209androgen metabolic process IEA--
    GO:0008210estrogen metabolic process ----


    HSD17B8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HSD17B8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HSD17B8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HSD17B8

    9 HMDB Compounds for HSD17B8    About this table
    CompoundSynonyms CAS #PubMed Ids
    16a-Hydroxyestrone16a-Hydroxyestrone (see all 5)566-76-7--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estriol13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol (see all 50)50-27-1--
    Estrone(+)-Estrone (see all 7)53-16-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    2 DrugBank Compounds for HSD17B8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423
    2'-Monophosphoadenosine 5'-Diphosphoribose-- --target--10592235

    1 Novoseek chemical compound relationship for HSD17B8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    steroid 23.5 2 8812499 (1), 9205114 (1)

    Search CenterWatch for drugs/clinical trials and news about HSD17B8 / DHB8 

    Transcripts
    for HSD17B8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HSD17B8 gene: 
    NM_014234.4  

    Unigene Cluster for HSD17B8:

    Hydroxysteroid (17-beta) dehydrogenase 8
    Hs.415058  [show with all ESTs]
    Unigene Representative Sequence: BQ651523
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374662(uc003odi.1) ENST00000469186

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    Inhib. RNA
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    Additional cDNA sequence: 

    BC008185.1 BT007239.1 D82061.1 

    4 DOTS entries:

    DT.100699398  DT.86841171  DT.211216  DT.95255443 

    24/365 AceView cDNA sequences (see all 365):

    CA454113 CB135931 BU688905 BP372590 AA319058 BE275203 AI888354 BP341645 
    BM792720 AI369736 BF991560 F31664 BP365155 AL555459 BC000645 BM825612 
    AA889452 BM831059 CR597948 AA918575 BQ068163 AW134912 BM460286 BQ958318 

    GeneLoc Exon Structure


    Expression
    for HSD17B8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSD17B8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAACTGCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HSD17B8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSD17B8

    SOURCE GeneReport for Unigene cluster: Hs.415058

    UniProtKB/Swiss-Prot: DHB8_HUMAN, Q92506
    Tissue specificity: Highly expressed in placenta, liver and pancreas, lower in the skeletal muscle and kidney. Widely
    expressed

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    In Situ
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    Orthologs
    for HSD17B8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HSD17B8 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NYK6_CHICK6
    		 Uncharacterized protein
    		 38(a)
    		 possible ortholog
    		 4(26632480-26636771)
    lizard
    (Anolis carolinensis)    		 Reptilia CBR46
    		 --
    		 38(a)
    		 possible ortholog
    		 GL343216.1(508833-517627)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.103162 Xenopus laevis transcribed sequence with weak similarity more 72.91(n)    BX844609.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fabgl2 FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, more 71.15(n)   64815  AF137536.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG36031 , 3 oxidoreductase, acting on CH-OH group of
    donors3
    CG36031    		 50(a)3
    55.23(n)1
    52.48(a)1    		   3C33
    312891  NM_130690.21  NP_570046.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea dhs-111 Protein DHS-11 54.32(n)
    51.85(a)    		   176485  NM_066945.1  NP_499346.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G243606
    		 3-oxoacyl-[acyl-carrier-protein] reductase
    		 31(a)
    		 possible ortholog
    		 1(8640582-8643478)
    rice
    (Oryza sativa)    		 Liliopsida Os04g03763001 hypothetical protein 51.23(n)
    48.77(a)    		   4335609  NM_001059115.1  NP_001052580.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria fabG6
    		 3-oxoacyl-[acyl-carrier-protein] reductase
    		 39(a)
    		 possible ortholog
    		 Chromosome(1149893-1150627)


    ENSEMBL Gene Tree for HSD17B8 (if available)
    TreeFam Gene Tree for HSD17B8 (if available) 

    Paralogs
    for HSD17B8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSD17B8 gene
    HPGD2  CBR42  DHRS112  HSD17B102  
    7 SIMAP similar genes for HSD17B8 using alignment to 1 protein entry:     DHB8_HUMAN:
    CBR4    HADH2    HSD17B10    DCXR    DHRS4    BDH2
    HSD17B4

    HSD17B8 for paralogs           About GeneDecksing



    Genomic Variants
    for HSD17B8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/43 NCBI SNPs in HSD17B8 are shown (see all 43)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1114933531,2
    		--33172755(+) GACCTG/AGACCG 2 /L syn11Minor allele frequency- A:0.50CSA 2
    rs751117011,2
    		C,F,--33172905(+) AACGCC/TAGGCC 1 -- int110Minor allele frequency- T:0.21NA WA CSA EA EU 1223
    rs1106621,2
    		C,F,A,H,--33172932(-) AATATT/CAGAGC 1 -- int125Minor allele frequency- C:0.15NA EA MN NS WA CSA 2767
    rs1919651951,2
    		--33172995(+) TCCCAC/TAGGCC 1 -- int10--------
    rs1383524491,2
    		--33173025(+) CTGTC-/GTTGTGTC 1 -- cds10--------
    rs1444572041,2
    		F--33173038(+) CTGTGC/TGGGCA 2 A V mis11Minor allele frequency- T:0.00NA 4542
    rs1837284881,2
    		--33173110(+) CAACCA/TCAAGG 2 H L mis10--------
    rs1451221171,2
    		--33173119(+) GGTGGC/TGATCT 1 -- int10--------
    rs1379200021,2
    		C,F,--33173138(+) GCGACG/CTTTGG 1 -- int11Minor allele frequency- C:0.01EU 1323
    rs1886080721,2
    		--33173142(+) CGTTTC/GGCCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for HSD17B8 (33172419 - 33174608 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSD17B8: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HSD17B8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HSD17B8 for disorders           About GeneDecksing

    OMIM gene information: 601417    OMIM disorders: --

    10 diseases for HSD17B8:    About MalaCards
    systemic lupus erythematosus    polycystic kidney disease    lupus erythematosus    kidney disease
    colorectal cancer    breast cancer    pneumonia    tuberculosis
    malaria    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: HSD17B8 (9 documents)

    Export disorders for HSD17B8 gene to outside databases

    Publications
    for HSD17B8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSD17B8 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HSD17B8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. (PubMed id 8812499)1, 2, 3, 9 Ando A.... Inoko H. (1996)
    2. Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. (PubMed id 18852215)1, 2, 9 Rotinen M.... Villar J. (2009)
    3. Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. (PubMed id 17978863)1, 2, 9 Ohno S.... Nakajin S. (2008)
    4. 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS. (PubMed id 19571038)1, 2 Chen Z.... Hiltunen J.K. (2009)
    5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. (PubMed id 9205114)1, 9 Kikuti Y.Y....Inoko H. (1997)
    9. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for HSD17B8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HSD17B8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7923 HGNC: 3554 AceView: SLC39A7andHSD17B8 Ensembl:ENSG00000204228 euGenes: HUgn7923
    ECgene: HSD17B8 Kegg: 7923 H-InvDB: HSD17B8

    Other Databases showing HSD17B8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HSD17B8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSD17B8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HSD17B8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HSD17B8 gene:
    Search GeneIP for patents involving HSD17B8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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