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HSD17B7P2 Gene

pseudogene   GIFtS: 27
GCID: GC10P038686

Hydroxysteroid (17-Beta) Dehydrogenase 7 Pseudogene 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 7 Pseudogene 21 2
HSD17B72
Hsd17b_22
bA291L22.12

External Ids:    HGNC: 281201   Entrez Gene: 1581602   Ensembl: ENSG000000992517   

Export aliases for HSD17B7P2 gene to outside databases

Previous GC identifers: GC10U900126 GC10P038353


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSD17B7P2 Gene:
HSD17B7P2 (hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSD17B7P2 gene promoter:
         AhR   ER-alpha   Sp1   HOXA3   GATA-3   CUTL1   LCR-F1   Arnt   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD17B7P2 promoter sequence
   Search Chromatin IP Primers for HSD17B7P2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSD17B7P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p11.1   Ensembl cytogenetic band:  10p11.1   HGNC cytogenetic band: 10p11.1

HSD17B7P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B7P2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P038686:  view genomic region     (about GC identifiers)

Start:
38,645,305 bp from pter      End:
38,667,433 bp from pter
Size:
22,129 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for HSD17B7P2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for HSD17B7P2

miRNA
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miRTarBase miRNAs that target HSD17B7P2:
hsa-mir-335-5p (MIRT017216)

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion2
cytosol1
extracellular1
nucleus1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSD17B7P2
Interactions:

    Search GeneGlobe Interaction Network for HSD17B7P2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HSD17B7P2

5 Novoseek inferred chemical compound relationships for HSD17B7P2 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zymosterol 91.9 1 12829805 (1)
17beta-hydroxysteroid 89.7 5 12829805 (1), 15862973 (1), 16901934 (1), 19735314 (1) (see all 5)
estradiol 53.5 1 19460435 (1)
sterol 52.5 3 12829805 (2), 16901934 (1)
cholesterol 40.8 5 12829805 (2), 15862973 (1), 16901934 (1)



Find genes that share compounds with HSD17B7P2           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HSD17B7P2 gene (2 alternative transcripts): 
NM_001031744.1  NM_182829.1  

Unigene Cluster for HSD17B7P2:

Hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
Hs.652484  [show with all ESTs]
Unigene Representative Sequence: BC071987
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000494540(uc001izq.3) ENST00000471365 ENST00000356314 ENST00000374560(uc010qew.1 uc001izp.1)
ENST00000277668(uc010qex.1 uc001izo.1)
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Additional mRNA sequence: 

AK295332.1 AK307174.1 BC071987.1 NR_003086.1 

10 DOTS entries:

DT.102827107  DT.95373297  DT.121292946  DT.100819444  DT.121292940  DT.121292945  DT.121292947  DT.95373298 
DT.121292941  DT.40229952 

Selected AceView cDNA sequences (see all 42):

BC071987 AL532435 AF165517 BU934909 BP346381 BM148133 BX483879 BQ352440 
AV660397 NM_182829 BG199997 AF165514 BG182213 BX484674 CD238202 AI874176 
BG470748 BI596476 AI351558 AA326268 BG426684 CD514563 AV691438 BE140115 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HSD17B7P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HSD17B7P2 Expression
About this image

HSD17B7P2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HSD17B7P2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.652484
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for HSD17B7P2 (if available)
TreeFam Gene Tree for HSD17B7P2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HSD17B7P2 (see all 445)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 10 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs582106461,2
C--38544814(+) TTTTC-/CTCGTG 1 -- int10--------
rs27544951,2
C,F,H--38643549(-) ccaccA/Gtgtct 1 -- us2k118Minor allele frequency- G:0.48NS EA NA WA CSA 1791
rs1122875561,2
C--38643558(+) GGAAGG/TGTGGC 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1924705431,2
--38643563(+) TGTGGC/TAGGCC 1 -- us2k10--------
rs28005521,2
C,F,A,H--38643616(-) gctttT/Caatat 1 -- us2k110Minor allele frequency- C:0.47NA WA CSA EA 371
rs28046391,2
C,F,A--38643663(+) CCCATC/TAAGAA 1 -- us2k13Minor allele frequency- T:0.50NA 6
rs1846892161,2
--38643700(+) TTAAAA/GCATAC 1 -- us2k10--------
rs1875044041,2
--38643757(+) GTTTTA/TTTGTG 1 -- us2k10--------
rs1928076781,2
--38643948(+) TTACAA/GATTAA 1 -- us2k10--------
rs1849270971,2
--38644124(+) CAGCTC/TATCTG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HSD17B7P2 (38645305 - 38667433 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for HSD17B7P2:    About this table    
Variant IDTypeSubtypePubMed ID
esv33710CNV Loss17666407
nsv428230CNV Loss18775914
nsv895030CNV Loss21882294
nsv895034CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HSD17B7P2 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with HSD17B7P2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7. (PubMed id 10544267)1, 3, 9 Krazeisen A.... Adamski J. (FEBS Lett. 1999)
  2. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. (PubMed id 12829805)1, 9 Marijanovic Z....Breitling R. (Mol. Endocrinol. 2003)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. Cloning and characterization of human form 2 type 7 17beta- hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme. (PubMed id 15862963)1 Liu H.... Luu-The V. (J. Steroid Biochem. Mol. Biol. 2005)
  5. Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. (PubMed id 12732193)1 Toern S.... Vihko P. (Biochem. Biophys. Res. Commun. 2003)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Single nucleotide polymorphisms of 17beta-hydroxysteroid dehydrogenase type 7 gene: mechanism of estramustine-related adverse reactions? (PubMed id 19735314)9 Ozeki T....Yamada Y. (Int. J. Urol. 2009)
  8. Transcriptional regulation of human and murine 17beta-hydroxysteroid dehydrogenase type-7 confers its participation in cholesterol biosynthesis. (PubMed id 16901934)9 Ohnesorg T....Adamski J. (J. Mol. Endocrinol. 2006)
  9. Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7. (PubMed id 15862973)9 Ohnesorg T. and Adamski J. (J. Steroid Biochem. Mol. Biol. 2005)
  10. Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer. (PubMed id 19460435)9 Plourde M....Simard J. (J. Steroid Biochem. Mol. Biol. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 158160 HGNC: 28120 AceView: LOC158160 Ensembl:ENSG00000099251 euGenes: HUgn158160
ECgene: HSD17B7P2 H-InvDB: HSD17B7P2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HSD17B7P2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
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Patent Information for HSD17B7P2 gene:
Search GeneIP for patents involving HSD17B7P2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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