Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HSD17B7 Gene

protein-coding   GIFtS: 63
GCID: GC01P162760

Hydroxysteroid (17-Beta) Dehydrogenase 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 71 2     17beta Hydroxysteroid Dehydrogenase2
Estradiol 17-Beta-Dehydrogenase 72 3     3-Keto-Steroid Reductase2
17-Beta-HSD 72 3     PRAP2
17-Beta-Hydroxysteroid Dehydrogenase 72 3     SDR37C12
Member 11     Short Chain Dehydrogenase/Reductase Family 37C, Member 12
Short Chain Dehydrogenase/Reductase Family 37C1     EC 1.1.1.2703
17 Beta-Hydroxysteroid Dehydrogenase Type VII2     EC 1.1.1.623

External Ids:    HGNC: 52151   Entrez Gene: 514782   Ensembl: ENSG000001321967   OMIM: 6067565   UniProtKB: P569373   

Export aliases for HSD17B7 gene to outside databases

Previous GC identifers: GC01P160395 GC01P158411 GC01P159456 GC01P159947 GC01P159492 GC01P161027 GC01P134005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HSD17B7 Gene:
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the
biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol
(Marijanovic et al., 2003 (PubMed 12829805)).(supplied by OMIM, May 2010)

GeneCards Summary for HSD17B7 Gene:
HSD17B7 (hydroxysteroid (17-beta) dehydrogenase 7) is a protein-coding gene. Diseases associated with HSD17B7 include ovarian endometriosis, and endometrial adenocarcinoma. GO annotations related to this gene include 3-keto sterol reductase activity and estradiol 17-beta-dehydrogenase activity.

UniProtKB/Swiss-Prot: DHB7_HUMAN, P56937
Function: Responsible for the reduction of the keto group on the C-3 of sterols

Gene Wiki entry for HSD17B7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSD17B7 gene promoter:
         ER-alpha   AREB6   GATA-3   POU2F1   Sp1   POU2F1a   Nkx2-5   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD17B7 promoter sequence
   Search Chromatin IP Primers for HSD17B7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSD17B7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q23

HSD17B7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162760:  view genomic region     (about GC identifiers)

Start:
162,760,492 bp from pter      End:
162,782,608 bp from pter
Size:
22,117 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DHB7_HUMAN, P56937 (See protein sequence)
Recommended Name: 3-keto-steroid reductase  
Size: 341 amino acids; 38206 Da
Secondary accessions: Q5T246 Q7Z4V9 Q8WWS2 Q9UF00
Alternative splicing: 3 isoforms:  P56937-1   P56937-2   P56937-3   

Explore the universe of human proteins at neXtProt for HSD17B7: NX_P56937

Explore proteomics data for HSD17B7 at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Ubiquitination2 at Lys20, Lys315
  • Glycosylation2 at Asn37, Asn178, Asn229
  • Modification sites at PhosphoSitePlus

  • See HSD17B7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057455.1  
    ENSEMBL proteins: 
     ENSP00000356892   ENSP00000436334   ENSP00000254521   ENSP00000356889   ENSP00000476930  
     ENSP00000356894  
    Reactome Protein details: P56937

    HSD17B7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HSD17B7
    OriGene Protein Over-expression Lysate for HSD17B7
    OriGene MassSpec for HSD17B7
    OriGene Custom Protein Services for HSD17B7
    GenScript Custom Purified and Recombinant Proteins Services for HSD17B7
    Novus Biologicals HSD17B7 Proteins
    Novus Biologicals HSD17B7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HSD17B7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSD17B7
    Novus Biologicals HSD17B7 Antibodies
    Abcam antibodies for HSD17B7
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for HSD17B7
    LSBio Antibodies in human, mouse, rat for HSD17B7

    HSD17B7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSD17B7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSD17B7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SDRC2: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry P56937

    ProtoNet protein and cluster: P56937

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHB7_HUMAN, P56937
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily


    HSD17B7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHB7_HUMAN, P56937
    Function: Responsible for the reduction of the keto group on the C-3 of sterols
    Catalytic activity: A 3-beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH
    Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H

         Genatlas biochemistry entry for HSD17B7:
    17 beta hydroxysteroid dehydrogenase type 7,expressed in the corpus luteum during pregnancy,responsible for
    extradive biosynthesis

         Enzyme Numbers (IUBMB): EC 1.1.1.621 EC 1.1.1.2701

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00002533-keto sterol reductase activity IEA--
    GO:0003824catalytic activity ----
    GO:0004303estradiol 17-beta-dehydrogenase activity IEA--
    GO:0005148prolactin receptor binding IEA--
    GO:0016491oxidoreductase activity ----
         
    HSD17B7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSD17B7:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hsd17b7):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  muscle  nervous system  skeleton 

    HSD17B7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hsd17b7tm1Gibo for HSD17B7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSD17B7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSD17B7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSD17B7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSD17B7

    miRNA
    Products:
        
    miRTarBase miRNAs that target HSD17B7:
    hsa-mir-155-5p (MIRT020937), hsa-mir-335-5p (MIRT018884)

    Block miRNA regulation of human, mouse, rat HSD17B7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSD17B7
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HSD17B7
    Predesigned siRNA for gene silencing in human, mouse, rat HSD17B7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSD17B7

    Clone
    Products:
         
    OriGene clones in human, mouse for HSD17B7 (see all 9)
    OriGene ORF clones in mouse, rat for HSD17B7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSD17B7 (NM_016371)
    Sino Biological Human cDNA Clone for HSD17B7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSD17B7
    Browse ESI BIO Cell Lines and PureStem Progenitors for HSD17B7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DHB7_HUMAN, P56937: Cell membrane; Single-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    cytosol2
    mitochondrion2
    extracellular1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    HSD17B7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HSD17B7 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1superpathway of cholesterol biosynthesis
    superpathway of cholesterol biosynthesis0.85
    zymosterol biosynthesis0.00
    Cholesterol biosynthesis0.85
    cholesterol biosynthesis I0.00
    cholesterol biosynthesis II (via 24,25-dihydrolanosterol)0.59
    cholesterol biosynthesis III (via desmosterol)0.00
    Steroid biosynthesis0.57
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Estrone metabolism
    Estrone metabolism0.57
    Estrogen biosynthesis0.47
    Androstenedione and testosterone biosynthesis and metabolism p.10.57
    4Prostate Cancer
    Prostate Cancer0.32
    Steroid Biosynthesis0.00
    5superpathway of steroid hormone biosynthesis
    superpathway of steroid hormone biosynthesis
    estradiol biosynthesis I0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for HSD17B7
        Estrogen biosynthesis
    Estrone metabolism
    Androstenedione and testosterone biosynthesis and metabolism p.1

    Selected BioSystems Pathways for HSD17B7 (see all 9)
        zymosterol biosynthesis
    Prostate Cancer
    superpathway of steroid hormone biosynthesis
    cholesterol biosynthesis I
    superpathway of cholesterol biosynthesis


    1 Reactome Pathway for HSD17B7
        Cholesterol biosynthesis


    4 Kegg Pathways  (Kegg details for HSD17B7):
        Steroid biosynthesis
    Steroid hormone biosynthesis
    Metabolic pathways
    Ovarian steroidogenesis

    UniProtKB/Swiss-Prot: DHB7_HUMAN, P56937
    Pathway: Steroid biosynthesis; estrogen biosynthesis
    Pathway: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6


    HSD17B7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSD17B7
    Interactions:

        Search GeneGlobe Interaction Network for HSD17B7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSD17B7 (ENSP000002545214) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSSENSP000003487624STRING: ENSP00000348762
    MSMO1ENSP000002615074STRING: ENSP00000261507
    C14orf1ENSP000002563194STRING: ENSP00000256319
    FDFT1ENSP000002205844STRING: ENSP00000220584
    SIGMAR1ENSP000002770104STRING: ENSP00000277010
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006695cholesterol biosynthetic process TAS--
    GO:0006703estrogen biosynthetic process IEA--
    GO:0008152metabolic process ----
    GO:0044237cellular metabolic process ----
    GO:0044281small molecule metabolic process TAS--

    HSD17B7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSD17B7 (DHB7)

    Selected HMDB Compounds for HSD17B7 (see all 19)    About this table
    CompoundSynonyms CAS #PubMed Ids
    16a-Hydroxyestrone16a-Hydroxyestrone (see all 5)566-76-7--
    3-Keto-4-methylzymosterol4-methyl-5a-cholesta-8,24-dien-3-one (see all 6)----
    4-alpha-Methyl-5-alpha-cholest-7-en-3-beta-ol4-a-Methyl-5-a-cholest-7-en-3-b-ol (see all 5)481-25-4--
    4-alpha-Methyl-5-alpha-cholest-7-en-3-one4alpha-Methyl-5alpha-cholest-7-en-3-one 2789-43-7--
    4a-Methyl-5a-cholesta-8,24-dien-3-one4alpha-methyl-5alpha-cholesta-8,24-dien-3-one 7377-73-3--
    4a-Methylzymosterol4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol (see all 7)7448-03-5--
    4a-Methylzymosterol-4-carboxylic acid4alpha-Carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol (see all 2)----
    5a-Cholesta-8,24-dien-3-one5alpha-cholesta-8,24-dien-3-one ----
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--

    1 DrugBank Compound for HSD17B7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    3 Novoseek inferred chemical compound relationships for HSD17B7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    17beta-hydroxysteroid 86.7 5 16356630 (1), 15731358 (1), 17498944 (1), 10544267 (1)
    steroid 32 2 17498944 (1)
    cholesterol 22.2 3 16356630 (1), 17498944 (1)



    HSD17B7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HSD17B7 gene: 
    NM_016371.2  

    Unigene Cluster for HSD17B7:

    Hydroxysteroid (17-beta) dehydrogenase 7
    Hs.492925  [show with all ESTs]
    Unigene Representative Sequence: AK022929
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000485405(uc001gci.3 uc009wuv.3) ENST00000463037 ENST00000367915
    ENST00000466176 ENST00000254521 ENST00000367913 ENST00000484251 ENST00000494450
    ENST00000470195 ENST00000488656 ENST00000367917
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSD17B7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSD17B7
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HSD17B7
    Predesigned siRNA for gene silencing in human, mouse, rat HSD17B7
    Clone
    Products:
         
    OriGene clones in human, mouse for HSD17B7 (see all 9)
    OriGene ORF clones in mouse, rat for HSD17B7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSD17B7 (NM_016371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSD17B7
    OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSD17B7
      QuantiTect SYBR Green Assays in human, mouse, rat HSD17B7
      QuantiFast Probe-based Assays in human, mouse, rat HSD17B7

    Additional mRNA sequence: 

    AF098786.2 AF145023.1 AJ249179.1 AK022929.1 AK290741.1 AY358962.1 BC007068.1 BC065246.1 
    BT007075.1 

    12 DOTS entries:

    DT.212132  DT.95356397  DT.40229952  DT.95373297  DT.100819443  DT.121355368  DT.40256072  DT.100819439 
    DT.121355374  DT.102827107  DT.121355367  DT.121355377 

    Selected AceView cDNA sequences (see all 95):

    NM_016371 CR625699 AW243862 AF098786 AJ249179 BT007075 BM825021 BQ440565 
    AI783561 BU674056 AI245405 BX101987 BF792897 AK022929 BU943150 CK905142 
    N77671 BC065246 CD511853 AV660397 BF982204 BG821616 AF145023 BM671219 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HSD17B7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCTACT
    HSD17B7 Expression
    About this image


    HSD17B7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Spleen (Hematopoietic System)
             Spleen
    HSD17B7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSD17B7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.492925

    UniProtKB/Swiss-Prot: DHB7_HUMAN, P56937
    Tissue specificity: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries,
    pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly
    expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine
    cells

        Custom PCR Arrays for HSD17B7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSD17B7
    OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSD17B7
    QuantiTect SYBR Green Assays in human, mouse, rat HSD17B7
    QuantiFast Probe-based Assays in human, mouse, rat HSD17B7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSD17B7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsd17b71 , 5 hydroxysteroid (17-beta) dehydrogenase 71, 5 80.42(n)1
    78.92(a)1
      1 (76.84 cM)5
    154901  NM_010476.31  NP_034606.31 
     1699495355 
    chicken
    (Gallus gallus)
    Aves HSD17B71 hydroxysteroid (17-beta) dehydrogenase 7 65.53(n)
    63.35(a)
      424367  NM_001277506.1  NP_001264435.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSD17B76
    hydroxysteroid (17-beta) dehydrogenase 7
    55(a)
    1 ↔ 1
    GL343300.1(1050153-1072291)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsd17b71 hydroxysteroid (17-beta) dehydrogenase 7 67.7(n)
    66.25(a)
      548963  NM_001016209.1  NP_001016209.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hsd17b71 hydroxysteroid (17-beta) dehydrogenase 7 64.2(n)
    61.11(a)
      768185  NM_001077328.1  NP_001070796.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG27(YLR100W)4
    ERG271
    3-keto sterol reductase, catalyzes the last of three more4
    ERG271
    42.98(n)1
    25.47(a)1
      12(341810-342853)4
    8507901, 4  NP_013201.11, 4 


    ENSEMBL Gene Tree for HSD17B7 (if available)
    TreeFam Gene Tree for HSD17B7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HSD17B7 gene
    1 SIMAP similar gene for HSD17B7 using alignment to 5 protein entries:     DHB7_HUMAN (see all proteins):
    RDH13

    HSD17B7 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for HSD17B7
    PGOHUM00000257786 PGOHUM00000257787 PGOHUM00000245051 PGOHUM00000245301


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HSD17B7 (see all 485)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131747971,2
    C--162763685(+) TTTTTC/TCCCTA 1 -- int10--------
    rs41466871,2
    C--162767247(+) TTTTTC/TCCCTT 1 -- int1 trp30--------
    rs3711176531,2
    C--162767247(-) AAGGG-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1165439361,2
    F--169308626(+) TTGAGG/ATCCCT 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs17800111,2
    C,A,H--169308637(-) gggtaA/Gcccat 1 -- us2k1 tfbs36Minor allele frequency- G:0.32NA EA 248
    rs1911223561,2
    --169308717(+) ATGGCA/TTGGCC 1 -- us2k10--------
    rs1837111051,2
    --169308764(+) CTTTCC/TCTTTC 1 -- us2k10--------
    rs577170021,2
    C,F--169308790(+) GGAAGT/GGTGGC 1 -- us2k12Minor allele frequency- G:0.09WA NA 238
    rs1889879961,2
    --169308869(+) AAAGGC/TTGGGA 1 -- us2k10--------
    rs1139100561,2
    C--169308874(+) CTGGGG/ATGTAA 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for HSD17B7 (162760492 - 162782608 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSD17B7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1698857CNV Insertion17803354
    nsv516482CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSD17B7
    DNA2.0 Custom Variant and Variant Library Synthesis for HSD17B7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606756    OMIM disorders: --

    10 diseases for HSD17B7:    
    About MalaCards
    ovarian endometriosis    endometrial adenocarcinoma    endometriosis    essential hypertension
    hypertension    ovarian cancer    adenocarcinoma    breast cancer
    prostate cancer    prostatitis


    HSD17B7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSD17B7
    Human Genome Epidemiology (HuGE) Navigator: HSD17B7 (6 documents)

    Export disorders for HSD17B7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HSD17B7 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with HSD17B7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7. (PubMed id 10544267)1, 2, 3, 9 Krazeisen A.... Adamski J. (FEBS Lett. 1999)
    2. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PubMed id 20140262)1, 4 Ryckman K.K....Jacobsson B. (PLoS ONE 2010)
    3. Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer. (PubMed id 20214802)1, 4 Li J....Hall P. (Breast Cancer Res. 2010)
    4. Analysis of 17beta-hydroxysteroid dehydrogenase types 5, 7, and 12 genetic sequence variants in breast cancer cases from French Canadian Families with high risk of breast and ovarian cancer. (PubMed id 19460435)1, 4 Plourde M....Simard J. (J. Steroid Biochem. Mol. Biol. 2009)
    5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    6. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. (PubMed id 19019335)1, 4 Velez D.R....Menon R. (Am. J. Obstet. Gynecol. 2009)
    7. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1, 4 Ehret G.B....Chakravarti A. (Eur. J. Hum. Genet. 2009)
    8. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51478 HGNC: 5215 AceView: HSD17B7 Ensembl:ENSG00000132196 euGenes: HUgn51478
    ECgene: HSD17B7 Kegg: 51478 H-InvDB: HSD17B7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HSD17B7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HSD17B7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HSD17B7 gene:
    Search GeneIP for patents involving HSD17B7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HSD17B7  
     OriGene qPCR primer pairs and template standards for HSD17B7   OriGene Protein Over-expression Lysate for HSD17B7  
     OriGene MassSpec something-or-other for HSD17B7   OriGene clones in human, mouse for HSD17B7  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B7   OriGene Purified Protein for HSD17B7  
     OriGene ORF clones in mouse, rat for HSD17B7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSD17B7   OriGene Custom Protein Services for HSD17B7  

     
     
     Block miRNA regulation of human, mouse, rat HSD17B7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HSD17B7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSD17B7 Predesigned siRNA for gene silencing in human, mouse, rat HSD17B7
     QuantiFast Probe-based Assays in human, mouse, rat HSD17B7 QuantiTect SYBR Green Assays in human, mouse, rat HSD17B7
     Custom PCR Arrays for HSD17B7 Search Chromatin IP Primers for HSD17B7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSD17B7  Search GeneGlobe Interaction Network for HSD17B7
     Regulatory tfbs in HSD17B7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HSD17B7 GenScript cDNA clones with any tag delivered in your preferred vector for HSD17B7
     GenScript Custom Assay Services for HSD17B7 GenScript Custom overexpressing Cell Line Services for HSD17B7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HSD17B7 (DHB7)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HSD17B7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HSD17B7 antibodies
     HSD17B7 proteins
     HSD17B7 lysates
     Antibodies for HSD17B7
     See all of Abcam's Antibodies, Kits and Proteins for HSD17B7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HSD17B7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B7
     SwitchGear 3'UTR luciferase reporter plasmids for HSD17B7
     SwitchGear Promoter luciferase reporter plasmids for HSD17B7
     Search ThermoFisher Antibodies for HSD17B7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSD17B7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSD17B7
     LSBio Antibodies in human, mouse, rat for HSD17B7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSD17B7 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4