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Aliases for HSD17B2 Gene

Aliases for HSD17B2 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 2 2 3
  • EDH17B2 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 9C Member 2 3 4
  • Microsomal 17-Beta-Hydroxysteroid Dehydrogenase 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase Type 2 3 4
  • 20 Alpha-Hydroxysteroid Dehydrogenase 3 4
  • Testosterone 17-Beta-Dehydrogenase 3 4
  • 17-Beta-HSD 2 3 4
  • 20-ALPHA-HSD 3 4
  • SDR9C2 3 4
  • E2DH 3 4
  • Short Chain Dehydrogenase/Reductase Family 9C, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 9C 2
  • Estradiol 17-Beta-Dehydrogenase 2 3
  • EC 4
  • EC 4
  • Member 2 2
  • HSD17 3

External Ids for HSD17B2 Gene

Previous GeneCards Identifiers for HSD17B2 Gene

  • GC16P072910
  • GC16P083029
  • GC16P081807
  • GC16P081848
  • GC16P080626
  • GC16P067822

Summaries for HSD17B2 Gene

GeneCards Summary for HSD17B2 Gene

HSD17B2 (Hydroxysteroid (17-Beta) Dehydrogenase 2) is a Protein Coding gene. Diseases associated with HSD17B2 include progesterone resistance and hereditary breast ovarian cancer. Among its related pathways are Metabolism and Prostate Cancer. GO annotations related to this gene include estradiol 17-beta-dehydrogenase activity and 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. An important paralog of this gene is HSD11B2.

UniProtKB/Swiss-Prot for HSD17B2 Gene

  • Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

Gene Wiki entry for HSD17B2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B2 Gene

Genomics for HSD17B2 Gene

Regulatory Elements for HSD17B2 Gene

Genomic Location for HSD17B2 Gene

82,035,004 bp from pter
82,098,534 bp from pter
63,531 bases
Plus strand

Genomic View for HSD17B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD17B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD17B2 Gene

Proteins for HSD17B2 Gene

  • Protein details for HSD17B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Estradiol 17-beta-dehydrogenase 2
    Protein Accession:
    Secondary Accessions:
    • B2R7T4

    Protein attributes for HSD17B2 Gene

    387 amino acids
    Molecular mass:
    42785 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HSD17B2 Gene

Proteomics data for HSD17B2 Gene at MOPED

Post-translational modifications for HSD17B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSD17B2 Gene

No data available for DME Specific Peptides for HSD17B2 Gene

Domains for HSD17B2 Gene

Gene Families for HSD17B2 Gene

  • SDRC2 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 2

Suggested Antigen Peptide Sequences for HSD17B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P37059
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B2: view

Function for HSD17B2 Gene

Molecular function for HSD17B2 Gene

GENATLAS Biochemistry: 17-beta-hydroxysteroid dehydrogenase,type II,microsomal,NAD dependent,converting estrogens and androgens,playing an essential role in the formation of active intracellular sex steroids
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.21 uM for estradiol {ECO:0000269 PubMed:8099587}; KM=0.39 uM for testosterone {ECO:0000269 PubMed:8099587}; KM=0.31 uM for dihydrotestosterone {ECO:0000269 PubMed:8099587}; KM=0.71 uM for 20-alpha-dihydroprogesterone {ECO:0000269 PubMed:8099587}; KM=0.78 uM for estrone {ECO:0000269 PubMed:8099587}; KM=2.63 uM for androstenedione {ECO:0000269 PubMed:8099587}; Vmax=38 nmol/min/mg enzyme with estradiol as substrate {ECO:0000269 PubMed:8099587}; Vmax=45 nmol/min/mg enzyme with testosterone as substrate {ECO:0000269 PubMed:8099587}; Vmax=38 nmol/min/mg enzyme with dihydrotestosterone as substrate {ECO:0000269 PubMed:8099587}; Vmax=5.6 nmol/min/mg enzyme with 20-alpha-dihydroprogesterone as substrate {ECO:0000269 PubMed:8099587}; Vmax=6.6 nmol/min/mg enzyme with estrone as substrate {ECO:0000269 PubMed:8099587}; Vmax=11.5 nmol/min/mg enzyme with androstenedione as substrate {ECO:0000269 PubMed:8099587};
UniProtKB/Swiss-Prot CatalyticActivity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
UniProtKB/Swiss-Prot CatalyticActivity: Testosterone + NAD(+) = androstenedione + NADH
UniProtKB/Swiss-Prot Function: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

Enzyme Numbers (IUBMB) for HSD17B2 Gene

Gene Ontology (GO) - Molecular Function for HSD17B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004303 estradiol 17-beta-dehydrogenase activity IDA 17538076
GO:0016491 oxidoreductase activity --
GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity TAS 17538076
GO:0047035 testosterone dehydrogenase (NAD+) activity IDA 8099587
genes like me logo Genes that share ontologies with HSD17B2: view
genes like me logo Genes that share phenotypes with HSD17B2: view

Animal Models for HSD17B2 Gene

MGI Knock Outs for HSD17B2:

miRNA for HSD17B2 Gene

miRTarBase miRNAs that target HSD17B2

No data available for Transcription Factor Targeting and HOMER Transcription for HSD17B2 Gene

Localization for HSD17B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B2 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for HSD17B2 Gene COMPARTMENTS Subcellular localization image for HSD17B2 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 2
lysosome 2
plasma membrane 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HSD17B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS 8099587
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HSD17B2: view

Pathways for HSD17B2 Gene

genes like me logo Genes that share pathways with HSD17B2: view

Pathways by source for HSD17B2 Gene

Interacting Proteins for HSD17B2 Gene

Gene Ontology (GO) - Biological Process for HSD17B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001890 placenta development IEA --
GO:0006694 steroid biosynthetic process IEA --
GO:0008152 metabolic process --
GO:0032526 response to retinoic acid IDA 17538076
genes like me logo Genes that share ontologies with HSD17B2: view

Compounds for HSD17B2 Gene

(10) HMDB Compounds for HSD17B2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 16a-Hydroxyestrone
  • (4)-Androsten-3,17-dione
  • (+)-3,17b-Estradiol
  • 13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol
  • (+)-Estrone

(1) Drugbank Compounds for HSD17B2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • beta-DPNH
606-68-8 target

(12) Novoseek inferred chemical compound relationships for HSD17B2 Gene

Compound -log(P) Hits PubMed IDs
17beta-hydroxysteroid 89.8 9
hydroxysteroid 77.8 2
estrone 76.7 5
dihydroprogesterone 73.5 3
estradiol 60.6 9
genes like me logo Genes that share compounds with HSD17B2: view

Transcripts for HSD17B2 Gene

mRNA/cDNA for HSD17B2 Gene

Unigene Clusters for HSD17B2 Gene

Hydroxysteroid (17-beta) dehydrogenase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP3: - -
SP4: - -

Relevant External Links for HSD17B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSD17B2 Gene

mRNA expression in normal human tissues for HSD17B2 Gene

mRNA differential expression in normal tissues according to GTEx for HSD17B2 Gene

This gene is overexpressed in Liver (20.6), Colon - Transverse (7.7), Bladder (6.8), and Small Intestine - Terminal Ileum (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSD17B2 Gene

SOURCE GeneReport for Unigene cluster for HSD17B2 Gene Hs.162795

genes like me logo Genes that share expressions with HSD17B2: view

No data available for mRNA Expression by UniProt/SwissProt for HSD17B2 Gene

Orthologs for HSD17B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD17B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSD17B2 35
  • 99.14 (n)
  • 99.48 (a)
HSD17B2 36
  • 99 (a)
(Bos Taurus)
Mammalia HSD17B2 35
  • 75.39 (n)
  • 65.54 (a)
HSD17B2 36
  • 65 (a)
(Canis familiaris)
Mammalia HSD17B2 35
  • 75.91 (n)
  • 68.53 (a)
HSD17B2 36
  • 58 (a)
(Mus musculus)
Mammalia Hsd17b2 35
  • 71.72 (n)
  • 61.17 (a)
Hsd17b2 16
Hsd17b2 36
  • 60 (a)
(Monodelphis domestica)
Mammalia HSD17B2 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia HSD17B2 36
  • 54 (a)
(Rattus norvegicus)
Mammalia Hsd17b2 35
  • 72.43 (n)
  • 62.77 (a)
(Gallus gallus)
Aves HSD17B2 35
  • 61.33 (n)
  • 55.47 (a)
HSD17B2 36
  • 53 (a)
(Anolis carolinensis)
Reptilia HSD17B2 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b2 35
  • 55.19 (n)
  • 46.88 (a)
(Danio rerio)
Actinopterygii hsd17b2 35
  • 54.69 (n)
  • 45.93 (a)
hsd17b2 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta e 36
  • 7 (a)
(Caenorhabditis elegans)
Secernentea dhs-20 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AYR1 38
LYS2 36
  • 5 (a)
Species with no ortholog for HSD17B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B2 Gene

Gene Tree for HSD17B2 (if available)
Gene Tree for HSD17B2 (if available)

Paralogs for HSD17B2 Gene

Selected SIMAP similar genes for HSD17B2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HSD17B2: view

Variants for HSD17B2 Gene

Sequence variations from dbSNP and Humsavar for HSD17B2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs723012 -- 82,085,167(+) CATTC(C/T)TGGAC intron-variant
rs723013 -- 82,085,599(+) CTCTG(G/T)TCTGT intron-variant
rs1017242 -- 82,092,179(-) TGGCA(A/G)CAAAA intron-variant
rs1017243 -- 82,091,945(-) TGTCC(C/T)AGAAA intron-variant
rs1034475 -- 82,086,638(-) TATCC(A/T)TACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B2 Gene

Variant ID Type Subtype PubMed ID
nsv907012 CNV Gain 21882294
esv2029415 CNV Deletion 18987734
esv2671131 CNV Deletion 23128226

Relevant External Links for HSD17B2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B2 Gene

Disorders for HSD17B2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for HSD17B2 Gene including...

Search for HSD17B2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for HSD17B2 Gene

(3) Novoseek inferred disease relationships for HSD17B2 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 38.8 9
tumors 0 3
cancer 0 2

Relevant External Links for HSD17B2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSD17B2: view

No data available for UniProtKB/Swiss-Prot for HSD17B2 Gene

Publications for HSD17B2 Gene

  1. Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. (PMID: 7759109) Durocher F. … Simard J. (Genomics 1995) 2 3 23
  2. Polymorphisms associated with circulating sex hormone levels in postmenopausal women. (PMID: 15199113) Dunning A.M. … Ponder B.A. (J. Natl. Cancer Inst. 2004) 3 23 48
  3. A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer. (PMID: 17260097) Jansson A. … StAYl O. (Breast Cancer Res. Treat. 2007) 3 23 48
  4. Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. (PMID: 20148360) Lin J. … Cook N.R. (Cancer Causes Control 2010) 3 23 48
  5. Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells. (PMID: 17538076) Su E.J. … Bulun S.E. (Biol. Reprod. 2007) 3 23 26

Products for HSD17B2 Gene

Sources for HSD17B2 Gene

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