Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HSD17B2 Gene

protein-coding GIFtS: 64
GCID: GC16P082068

hydroxysteroid (17-beta) dehydrogenase 2

Explore 18 diseases affiliated with
HSD17B2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 2¹ ²		20 Alpha-Hydroxysteroid Dehydrogenase² ³
EDH17B2² ³ ⁵		20-Alpha-HSD¹
HSD17¹ ²		E2DH² ³
SDR9C2¹ ²		Estradiol 17-Beta-Dehydrogenase 2²
Microsomal 17-Beta-Hydroxysteroid Dehydrogenase² ³		Short Chain Dehydrogenase/Reductase Family 9C, Member 2²
Testosterone 17-Beta-Dehydrogenase² ³		EC 1.1.1.239³
17-Beta-HSD 2² ³		EC 1.1.1.62³
17-Beta-Hydroxysteroid Dehydrogenase Type 2² ³

External Ids:	HGNC: 5211¹	Entrez Gene: 3294²	Ensembl: ENSG00000086696⁷	OMIM: 109685⁵	UniProtKB: P37059³

Export aliases for HSD17B2 gene to outside databases

Previous GC identifers: GC16P072910 GC16P083029 GC16P081807 GC16P081848 GC16P080626 GC16P067822

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DHB2_HUMAN, P37059

Function: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and

estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

Gene Wiki entry for HSD17B2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HSD17B2 gene promoter:
STAT5B HOXA9 HOXA9B MyoD HNF-3beta SRY PPAR-gamma1 PPAR-gamma2 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HSD17B2 promoter sequence

Search SABiosciences Chromatin IP Primers for HSD17B2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.1-q24.2 Ensembl cytogenetic band: 16q23.3 HGNC cytogenetic band: 16q24.1-q24.2

HSD17B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P082068: view genomic region (about GC identifiers)

Start:	82,068,609 bp from pter	End:	82,132,139 bp from pter
Size:	63,531 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHB2_HUMAN, P37059 (See protein sequence)

Recommended Name: Estradiol 17-beta-dehydrogenase 2

Size: 387 amino acids; 42785 Da

Subcellular location: Membrane; Single-pass type II membrane protein (Potential)

Secondary accessions: B2R7T4

Explore the universe of human proteins at neXtProt for HSD17B2: NX_P37059

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P37059

HSD17B2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002144.1

ENSEMBL proteins:

ENSP00000455992 ENSP00000199936 ENSP00000457943 ENSP00000454931 ENSP00000456529

ENSP00000456471

Human Recombinant Protein Products for HSD17B2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HSD17B2 OriGene Protein Over-expression Lysate: HSD17B2 OriGene Custom Protein Services for HSD17B2
	GenScript Custom Purified and Recombinant Proteins Services for HSD17B2
	Novus Biologicals HSD17B2 Proteins Novus Biologicals HSD17B2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	8099587
GO:0005792	microsome	--	--
GO:0016021	integral to membrane	IEA	--

HSD17B2 for ontologies About GeneDecksing

HSD17B2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): HSD17B2 OriGene Custom Antibody Services for HSD17B2
	GenScript Custom Superior Antibodies Services for HSD17B2
	Novus Biologicals HSD17B2 Antibodies
	Abcam antibodies for HSD17B2
	Browse Antibodies at Uscn
	ThermoFisher Antibody for HSD17B2

Assay Products for HSD17B2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HSD17B2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HSD17B2 for domains About GeneDecksing

4 InterPro domains/families:

IPR020904 Sc_DH/Rdtase_CS

IPR002347 Glc/ribitol_DH

IPR002198 DH_sc/Rdtase_SDR

IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry P37059

ProtoNet protein and cluster: P37059

1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR

UniProtKB/Swiss-Prot: DHB2_HUMAN, P37059

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DHB2_HUMAN, P37059

Function: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and

estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH

Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H

Catalytic activity: Testosterone + NAD(+) = androstenedione + NADH

Biophysicochemical properties: Kinetic parameters: KM=0.21 uM for estradiol; KM=0.39 uM for testosterone; KM=0.31 uM

for dihydrotestosterone; KM=0.71 uM for 20-alpha-dihydroprogesterone; KM=0.78 uM for estrone; KM=2.63 uM for

androstenedione; Vmax=38 nmol/min/mg enzyme with estradiol as substrate; Vmax=45 nmol/min/mg enzyme with testosterone

as substrate; Vmax=38 nmol/min/mg enzyme with dihydrotestosterone as substrate; Vmax=5.6 nmol/min/mg enzyme with

20-alpha-dihydroprogesterone as substrate; Vmax=6.6 nmol/min/mg enzyme with estrone as substrate; Vmax=11.5

nmol/min/mg enzyme with androstenedione as substrate;

Genatlas biochemistry entry for HSD17B2:

17-beta-hydroxysteroid dehydrogenase,type II,microsomal,NAD dependent,converting estrogens and androgens,playing an

essential role in the formation of active intracellular sex steroids

Enzyme Numbers (IUBMB): EC 1.1.1.62¹ EC 1.1.1.239¹

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004303	estradiol 17-beta-dehydrogenase activity	IDA	17538076
GO:0016491	oxidoreductase activity	--	--
GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	TAS	17538076
GO:0047035	testosterone dehydrogenase (NAD+) activity	IEA	--

HSD17B2 for ontologies About GeneDecksing

Phenotypes:
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hsd17b2):

behavior/neurological	craniofacial	embryogenesis	growth/size	mortality/aging
nervous system	renal/urinary system

HSD17B2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Hsd17b2^tm1Mpo for HSD17B2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HSD17B2

miRNA Products:		OriGene 3'-UTR Clone: HSD17B2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD17B2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HSD17B2:
		hsa-miR-204 hsa-miR-211
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD17B2 (see all 7) OriGene shRNA RFP: HSD17B2 OriGene siRNA: HSD17B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B2
		Sirion Biotech Custom design and validation of potent shRNA sequences against HSD17B2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HSD17B2
			Sirion Biotech Customized adenovirus for overexpression of HSD17B2 Sirion Biotech Customized adenovirus for potent knockdown of HSD17B2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSD17B2 (NM_002153)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSD17B2
		Search LifeMap BioReagents cell lines for HSD17B2
		Sirion Biotech Customized stable knockdown cell line services for HSD17B2 Sirion Biotech Customized inducible knockdown cell line services for HSD17B2 Sirion Biotech Customized stable overexpressing cell line services for HSD17B2 Sirion Biotech Customized inducible overexpressing cell line services for HSD17B2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Estrone metabolism

Estrone metabolism	1.00	Estrogen biosynthesis	0.47
Estrone metabolism	1.00	Estrogen biosynthesis	0.47
Androstenedione and testosterone biosynthesis and metabolism p.1	0.57	Steroid Biosynthesis	0.21
Androstenedione and testosterone biosynthesis and metabolism p.1	0.57

Steroid hormone biosynthesis

Steroid hormone biosynthesis

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HSD17B2

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estrone metabolism
	Estrogen biosynthesis

3 GeneGo (Thomson Reuters) Pathways for HSD17B2

	Estrogen biosynthesis
	Estrone metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

1 BioSystems Pathway for HSD17B2

Steroid Biosynthesis

2 Kegg Pathways (Kegg details for HSD17B2):

	Steroid hormone biosynthesis
	Metabolic pathways

HSD17B2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HSD17B2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for HSD17B2 (ENSP00000199936⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AKR1D1	ENSP00000242375⁴	STRING: ENSP00000242375
CYP11B1	ENSP00000292427⁴	STRING: ENSP00000292427
CYP19A1	ENSP00000260433⁴	STRING: ENSP00000260433
CYP1A1	ENSP00000369050⁴	STRING: ENSP00000369050
CYP1B1	ENSP00000260630⁴	STRING: ENSP00000260630

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001890	placenta development	IEA	--
GO:0006694	steroid biosynthetic process	IEA	--
GO:0006702	androgen biosynthetic process	--	--
GO:0006703	estrogen biosynthetic process	--	--

HSD17B2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HSD17B2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HSD17B2

10 HMDB Compounds for HSD17B2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Androstenedione	(4)-Androsten-3,17-dione (see all 14)	63-05-8	17538076
16a-Hydroxyestrone	16a-Hydroxyestrone (see all 5)	566-76-7	--
Estradiol	(+)-3,17b-Estradiol (see all 83)	50-28-2	--
Estriol	13b-Methyl-1,3,5(10)-gonatriene-3,16a,17b-triol (see all 50)	50-27-1	--
Estrone	(+)-Estrone (see all 7)	53-16-7	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Testosterone	(+)-testosterone (see all 86)	58-22-0	--

1 DrugBank Compound for HSD17B2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	3463506 17139284 17016423 8529651 2615366

10/12 Novoseek chemical compound relationships for HSD17B2 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
17beta-hydroxysteroid	89.8	8	8125484 (1), 16807381 (1), 17538076 (1), 20108182 (1) (see all 9)
hydroxysteroid	77.8	3	17510238 (1), 18348690 (1)
estrone	76.7	4	1551473 (1), 17538076 (1), 1958511 (1), 16896040 (1) (see all 5)
dihydroprogesterone	73.5	3	17510238 (1), 17538076 (1), 14967895 (1)
estradiol	60.6	8	1958511 (2), 18270252 (2), 1551473 (1), 16807381 (1) (see all 7)
androstenedione	58.9	1	17538076 (1), 16896040 (1)
testosterone	56.3	4	17538076 (1), 12361724 (1), 17085046 (1), 14967895 (1) (see all 5)
17-hydroxyprogesterone	54.4	1	14967895 (1)
progesterone	50.4	15	16807381 (4), 20108182 (3), 11165014 (2), 17510238 (1) (see all 8)
steroid	45.5	2	1551473 (1), 17085046 (1)

Search CenterWatch for drugs/clinical trials and news about HSD17B2 / DHB2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HSD17B2 gene:

NM_002153.2

Unigene Cluster for HSD17B2:

Hydroxysteroid (17-beta) dehydrogenase 2

Hs.162795 [show with all ESTs]

Unigene Representative Sequence: BX648557

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000563491 ENST00000199936(uc002fgv.3) ENST00000566213 ENST00000569351

ENST00000568090 ENST00000566838 ENST00000564265

miRNA Products:		OriGene 3'-UTR Clone: HSD17B2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD17B2
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HSD17B2:
		hsa-miR-204 hsa-miR-211
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD17B2 (see all 7) OriGene shRNA RFP: HSD17B2 OriGene siRNA: HSD17B2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B2
		Sirion Biotech Custom design and validation of potent shRNA sequences against HSD17B2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HSD17B2 (NM_002153)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD17B2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSD17B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B2

Additional cDNA sequence:

AK223001.1 AK313109.1 BC009581.1 BC059170.1 BX648557.1 L11708.1

10 DOTS entries:

DT.211464 DT.100817166 DT.95171576 DT.100817157 DT.100817162 DT.95171579 DT.100029949 DT.120717073

DT.120717082 DT.97865470

24/128 AceView cDNA sequences (see all 128):

CR599647 CR600847 CA311161 BU734725 CR614043 CR590260 CR595758 BG619123

BM821329 BI042465 AI393964 AL546227 CR624530 BM712256 CB240853 CR601534

AL552206 BG618530 BM771692 CR615010 BG572676 NM_002153 CR623916 BC009581

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9
SP1:					-										-		-
SP2:
SP3:			-		-
SP4:					-		-
SP5:

ECgene alternative splicing isoforms for HSD17B2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HSD17B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGAGCTC

About this image

HSD17B2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

See HSD17B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HSD17B2

SOURCE GeneReport for Unigene cluster: Hs.162795

SABiosciences Expression via Pathway-Focused PCR Array including HSD17B2:

Drug Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD17B2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HSD17B2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for HSD17B2 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	HSD17B2¹	hydroxysteroid (17-beta) dehydrogenase 2	61.33(n) 55.73(a)		415807 XM_414168.3 XP_414168.3
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	24(a) 19(a) (see all 4)	possible ortholog possible ortholog (see all 4)	6(68513343-68523966) 4(88258680-88266957)
zebrafish (Danio rerio)	Actinopterygii	hsd17b2¹	hydroxysteroid (17-beta) dehydrogenase 2	54.69(n) 45.93(a)		449537 NM_001040188.1 NP_001035278.1
fruit fly (Drosophila melanogaster)	Insecta	sro⁶ CG8888⁶	--	23(a) 22(a)	1 ↔ many possible ortholog	3R(25620358-25621420) 2R(7952070-7967048)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	AYR1(YIL124W)⁴ AYR1¹	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase more⁴ Ayr1p¹	41.05(n)¹ 31.05(a)¹		9(126204-127097)⁴ 854682^{1, 4} NP_012142.3¹ NP_012142.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G65205⁶ AT5G10050⁶	1-acylglycerone phosphate reductase	21(a) 21(a)	possible ortholog possible ortholog	5(26050810-26052034) 5(3144200-3145730)
rice (Oryza sativa)	Liliopsida	-- --	oxidoreductase, short chain dehydrogenase/reductas... oxidoreductase, short chain dehydrogenase/reductas...	18(a) 18(a)	possible ortholog possible ortholog	12(27135120-27136028) 4(22652738-22655412)
E. coli (Escherichia coli)	Gamma proteobacteria	ybbO⁶	predicted oxidoreductase with NAD(P)-binding Rossm...	23(a)	possible ortholog	Chromosome(517564-518373)

ENSEMBL Gene Tree for HSD17B2 (if available)
TreeFam Gene Tree for HSD17B2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HSD17B2 gene

SDR9C7² DHRS9² HSD11B2² HSD17B6² BDH1² RDH8² RDH16² DHRS7B²

DHRS7² HSD17B1² KDSR² DHRS7C² RDH5²

8 SIMAP similar genes for HSD17B2 using alignment to 6 protein entries: DHB2_HUMAN (see all proteins):

HSD11B2 RDHL BDH1 HSD17B6 SDR9C7 DHRS9

RDH5 RDH16

HSD17B2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78024908^1,2	F	--	82066906(+)	`TTTTTC/TGAACG`	1	--	us2k¹		1		NA	120
rs183232610^1,2		--	82066929(+)	`AGGATA/GCTCTG`	1	--	us2k¹		0	--	--	--	--
rs8061331^1,2	C,F,A,H	--	82066970(+)	`TGCCCT/CGTGGC`	1	--	us2k¹		7		NS WA NA CSA	303
rs8054931^1,2	C,F,A,H	--	82066971(+)	`GCCCTG/ATGGCT`	1	--	us2k¹		8		NS EA WA NA CSA	600
rs187928973^1,2		--	82066991(+)	`CCCAGC/GAAGGA`	1	--	us2k¹		0	--	--	--	--
rs190934708^1,2		--	82067012(+)	`GTTGAA/GGGAGG`	1	--	us2k¹		0	--	--	--	--
rs8191044^1,2	C,F,H	--	82067039(+)	`CCAAAG/CGCAAT`	1	--	us2k¹ tfbs³		14		NS EA WA CSA	1194
rs182642399^1,2		--	82067074(+)	`CTGGCC/TTGGAG`	1	--	us2k¹		0	--	--	--	--
rs8191045^1,2	C,F,H	--	82067083(+)	`AGCTGG/CTAACG`	1	--	us2k¹		6		NS EA WA	716
rs8191046^1,2	H	--	82067204(+)	`GTAATG/CGTTCA`	1	--	us2k¹		5		NS EA	584

HapMap Linkage Disequilibrium report for HSD17B2 (82068609 - 82132139 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HSD17B2
1 Indel: 45471
Human Gene Mutation Database (HGMD): HSD17B2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSD17B2

DNA2.0 Custom Variant and Variant Library Synthesis for HSD17B2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HSD17B2 for disorders           About GeneDecksing

OMIM gene information: 109685    OMIM disorders: --

18 diseases for HSD17B2:    About MalaCards

progesterone resistance breast-ovarian cancer polycystic ovary syndrome hereditary breast ovarian cancer

sporadic breast cancer ovarian cancer familial prostate cancer breast cancer

prostate cancer pulmonary disease endometriosis meningioma

colorectal cancer prostatitis esophagitis tuberculosis

adenocarcinoma mycobacterium tuberculosis

2 diseases from the University of Copenhagen DISEASES database for HSD17B2:

Endometriosis Hereditary breast ovarian cancer

3 Novoseek disease relationships for HSD17B2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	38.8	11	8125484 (2), 8003440 (2), 1958511 (2), 17260097 (2) (see all 5)
tumors	0	3	1551473 (1), 12361724 (1), 1958511 (1)
cancer	0	2	8401501 (2)

Genetic Association Database (GAD): HSD17B2
Human Genome Epidemiology (HuGE) Navigator: HSD17B2 (26 documents)

Export disorders for HSD17B2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HSD17B2 gene, integrated from 9 sources (see all 89):
(articles sorted by number of sources associating them with HSD17B2)

Utopia: connect your pdf to the dynamic
world of online information

Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells. (PubMed id 17538076)^{1, 6, 9} Su E.J....Bulun S.E. (2007)
Mapping of the HSD17B2 gene encoding type II 17 beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. (PubMed id 7759109)^{1, 3, 9} Durocher F....Simard J. (1995)
Polymorphisms associated with circulating sex hormone levels in postmenopausal women. (PubMed id 15199113)^{1, 4, 9} Dunning A.M....Ponder B.A. (2004)
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species. (PubMed id 7546291)^{1, 2} Labrie Y....Labrie F. (1995)
Expression cloning and characterization of human 17 beta- hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. (PubMed id 8099587)^{1, 2} Wu L....Andersson S. (1993)
SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium. (PubMed id 16807381)^{1, 9} Cheng Y.H....Bulun S.E. (2006)
A new polymorphism in the coding region of exon four in HSD17B2 in relation to risk of sporadic and hereditary breast cancer. (PubMed id 17260097)^{1, 9} Jansson A....Stal O. (2007)
Genetic variation in sex-steroid receptors and synthe sizing enzymes and colorectal cancer risk in women. (PubMed id 20148360)^{1, 9} Lin J....Cook N.R. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3294	HGNC: 5211	AceView: HSD17B2	Ensembl:ENSG00000086696	euGenes: HUgn3294
ECgene: HSD17B2	Kegg: 3294	H-InvDB: HSD17B2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HSD17B2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HSD17B2	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/hsd17b2/

Intellectual Property for HSD17B2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HSD17B2 gene:
Search GeneIP for patents involving HSD17B2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for HSD17B2		OriGene shRNA RFP for HSD17B2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD17B2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD17B2
	OriGene Protein Over-expression Lysate for HSD17B2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HSD17B2		OriGene 3'-UTR Clone for HSD17B2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HSD17B2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HSD17B2		OriGene Custom Protein Services for HSD17B2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSD17B2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSD17B2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B2

	GenScript Custom Purified and Recombinant Proteins Services for HSD17B2		GenScript cDNA clones with any tag delivered in your preferred vector for HSD17B2
	GenScript Custom Assay Services for HSD17B2		GenScript Custom Superior Antibodies Services for HSD17B2
	GenScript Custom overexpressing Cell Line Services for HSD17B2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HSD17B2 promoter
	Search Chromatin IP Primers for HSD17B2
	RT² qPCR Primer Assay in human, mouse, rat HSD17B2
	GNC Network for HSD17B2
	SABiosciences PCR Arrays including human, mouse, rat HSD17B2

Search Tocris compounds for HSD17B2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HSD17B2 antibodies
	HSD17B2 proteins
	HSD17B2 lysates

	Antibodies for HSD17B2
	See all of Abcam's Antibodies, Kits and Proteins for HSD17B2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for HSD17B2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HSD17B2
	SwitchGear Promoter luciferase reporter plasmids for HSD17B2

ThermoFisher Antibody for HSD17B2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HSD17B2

Sirion Biotech Customized:

	stable knockdown cell line services for HSD17B2
	inducible knockdown cell line services for HSD17B2
	design and validation of potent shRNA sequences against HSD17B2
	adenovirus for potent knockdown of HSD17B2
	adenovirus for overexpression of HSD17B2
	stable overexpressing cell line services for HSD17B2
	inducible overexpressing cell line services for HSD17B2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HSD17B2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

HSD17B2 Gene

hydroxysteroid (17-beta) dehydrogenase 2

Aliases
for HSD17B2 gene

Summaries
for HSD17B2 gene

Genomic Views
for HSD17B2 gene

Proteins
for HSD17B2 gene

Protein Domains /
Families
for HSD17B2 gene

Function
for HSD17B2 gene

Pathways & Interactions
for HSD17B2 gene

Drugs & Compounds
for HSD17B2 gene

Transcripts
for HSD17B2 gene

Expression
for HSD17B2 gene

Orthologs
for HSD17B2 gene

Paralogs
for HSD17B2 gene

Genomic Variants
for HSD17B2 gene

Disorders / Diseases
for HSD17B2 gene

Publications
for HSD17B2 gene

External Searches for HSD17B2 gene

Genome Databases showing HSD17B2 gene

Other Databases showing HSD17B2 gene

Specialized Databases showing HSD17B2 gene

Intellectual Property
for HSD17B2 gene

Products
for HSD17B2 gene

View Random Gene

Advanced Search

Export list of displayed genes

HSD17B2 Gene

hydroxysteroid (17-beta) dehydrogenase 2

Aliasesfor HSD17B2 gene

Summariesfor HSD17B2 gene

Genomic Viewsfor HSD17B2 gene

Proteinsfor HSD17B2 gene

Protein Domains /Familiesfor HSD17B2 gene

Functionfor HSD17B2 gene

Pathways & Interactionsfor HSD17B2 gene

Drugs & Compoundsfor HSD17B2 gene

Transcriptsfor HSD17B2 gene

Expression for HSD17B2 gene

Orthologsfor HSD17B2 gene

Paralogsfor HSD17B2 gene

Genomic Variantsfor HSD17B2 gene

Disorders / Diseasesfor HSD17B2 gene

Publicationsfor HSD17B2 gene

External Searches for HSD17B2 gene

Genome Databases showing HSD17B2 gene

Other Databases showing HSD17B2 gene

Specialized Databases showing HSD17B2 gene

Intellectual Propertyfor HSD17B2 gene

Productsfor HSD17B2 gene

View Random Gene

Aliases
for HSD17B2 gene

Summaries
for HSD17B2 gene

Genomic Views
for HSD17B2 gene

Proteins
for HSD17B2 gene

Protein Domains /
Families
for HSD17B2 gene

Function
for HSD17B2 gene

Pathways & Interactions
for HSD17B2 gene

Drugs & Compounds
for HSD17B2 gene

Transcripts
for HSD17B2 gene

Expression
for HSD17B2 gene

Orthologs
for HSD17B2 gene

Paralogs
for HSD17B2 gene

Genomic Variants
for HSD17B2 gene

Disorders / Diseases
for HSD17B2 gene

Publications
for HSD17B2 gene

Intellectual Property
for HSD17B2 gene

Products
for HSD17B2 gene