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Aliases for HSD17B14 Gene

Aliases for HSD17B14 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 14 2 3
  • DHRS10 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 47C Member 1 3 4
  • Retinal Short-Chain Dehydrogenase/Reductase RetSDR3 3 4
  • Dehydrogenase/Reductase (SDR Family) Member 10 2 3
  • Retinal Short-Chain Dehydrogenase/Reductase 3 2 3
  • Dehydrogenase/Reductase SDR Family Member 10 3 4
  • 17-Beta-Hydroxysteroid Dehydrogenase DHRS10 3 4
  • 17-Beta-HSD 14 3 4
  • RetSDR3 3 6
  • SDR47C1 3 4
  • Short Chain Dehydrogenase/Reductase Family 47C, Member 1 3
  • Short Chain Dehydrogenase/Reductase Family 47C 2
  • 17-Beta-Hydroxysteroid Dehydrogenase 14 3
  • EC 1.1.1.- 4
  • Member 1 2
  • SDR3 4

External Ids for HSD17B14 Gene

Previous HGNC Symbols for HSD17B14 Gene

  • DHRS10

Previous GeneCards Identifiers for HSD17B14 Gene

  • GC19M054009
  • GC19M049316
  • GC19M045695

Summaries for HSD17B14 Gene

Entrez Gene Summary for HSD17B14 Gene

  • 17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

GeneCards Summary for HSD17B14 Gene

HSD17B14 (Hydroxysteroid (17-Beta) Dehydrogenase 14) is a Protein Coding gene. Diseases associated with HSD17B14 include estrogen-receptor positive breast cancer. GO annotations related to this gene include estradiol 17-beta-dehydrogenase activity and testosterone 17-beta-dehydrogenase (NADP+) activity. An important paralog of this gene is DECR2.

UniProtKB/Swiss-Prot for HSD17B14 Gene

  • Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B14 Gene

Genomics for HSD17B14 Gene

Regulatory Elements for HSD17B14 Gene

Genomic Location for HSD17B14 Gene

48,813,017 bp from pter
48,836,678 bp from pter
23,662 bases
Minus strand

Genomic View for HSD17B14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD17B14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD17B14 Gene

Proteins for HSD17B14 Gene

  • Protein details for HSD17B14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    17-beta-hydroxysteroid dehydrogenase 14
    Protein Accession:
    Secondary Accessions:
    • Q9UKU3

    Protein attributes for HSD17B14 Gene

    270 amino acids
    Molecular mass:
    28317 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for HSD17B14 Gene

neXtProt entry for HSD17B14 Gene

Proteomics data for HSD17B14 Gene at MOPED

Post-translational modifications for HSD17B14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSD17B14 Gene

No data available for DME Specific Peptides for HSD17B14 Gene

Domains for HSD17B14 Gene

Gene Families for HSD17B14 Gene

  • SDRC1 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 1

Suggested Antigen Peptide Sequences for HSD17B14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BPX1
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B14: view

Function for HSD17B14 Gene

Molecular function for HSD17B14 Gene

UniProtKB/Swiss-Prot Function: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).

Enzyme Numbers (IUBMB) for HSD17B14 Gene

Gene Ontology (GO) - Molecular Function for HSD17B14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004303 estradiol 17-beta-dehydrogenase activity IDA 17067289
GO:0005515 protein binding IPI 16189514
GO:0016491 oxidoreductase activity --
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity IDA 17067289
genes like me logo Genes that share ontologies with HSD17B14: view

Phenotypes for HSD17B14 Gene

GenomeRNAi human phenotypes for HSD17B14:
genes like me logo Genes that share phenotypes with HSD17B14: view

miRNA for HSD17B14 Gene

miRTarBase miRNAs that target HSD17B14

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HSD17B14 Gene

Localization for HSD17B14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B14 Gene


Subcellular locations from

Jensen Localization Image for HSD17B14 Gene COMPARTMENTS Subcellular localization image for HSD17B14 gene
Compartment Confidence
cytoskeleton 4
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HSD17B14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 17067289
genes like me logo Genes that share ontologies with HSD17B14: view

Pathways for HSD17B14 Gene

SuperPathways for HSD17B14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSD17B14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006706 steroid catabolic process IDA 17067289
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD17B14: view

No data available for Pathways by source for HSD17B14 Gene

Compounds for HSD17B14 Gene

(1) HMDB Compounds for HSD17B14 Gene

Compound Synonyms Cas Number PubMed IDs
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
genes like me logo Genes that share compounds with HSD17B14: view

Transcripts for HSD17B14 Gene

Unigene Clusters for HSD17B14 Gene

Hydroxysteroid (17-beta) dehydrogenase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - -

Relevant External Links for HSD17B14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSD17B14 Gene

mRNA expression in normal human tissues for HSD17B14 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSD17B14 Gene

SOURCE GeneReport for Unigene cluster for HSD17B14 Gene Hs.18788

mRNA Expression by UniProt/SwissProt for HSD17B14 Gene

Tissue specificity: Highly expressed in brain, placenta, liver and kidney.
genes like me logo Genes that share expressions with HSD17B14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSD17B14 Gene

Orthologs for HSD17B14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD17B14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HSD17B14 35
  • 98.25 (n)
  • 96.49 (a)
HSD17B14 36
  • 97 (a)
(Bos Taurus)
Mammalia HSD17B14 35
  • 85.56 (n)
  • 86.67 (a)
HSD17B14 36
  • 87 (a)
(Canis familiaris)
Mammalia HSD17B14 35
  • 86.42 (n)
  • 85.19 (a)
HSD17B14 36
  • 85 (a)
(Mus musculus)
Mammalia Hsd17b14 35
  • 82.9 (n)
  • 81.78 (a)
Hsd17b14 16
Hsd17b14 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia HSD17B14 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Hsd17b14 35
  • 82.28 (n)
  • 80.67 (a)
(Gallus gallus)
Aves HSD17B14 36
  • 13 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
-- 36
  • 55 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32139 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498205 35
  • 60.23 (n)
  • 58.8 (a)
(Danio rerio)
Actinopterygii hsd17b14 35
  • 58.76 (n)
  • 58.19 (a)
hsd17b14 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011852 35
  • 48.78 (n)
  • 37.5 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51680 35
  • 43.48 (n)
  • 34.35 (a)
(Oryza sativa)
Liliopsida Os07g0691600 35
  • 51.17 (n)
  • 40.79 (a)
Species with no ortholog for HSD17B14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSD17B14 Gene

Gene Tree for HSD17B14 (if available)
Gene Tree for HSD17B14 (if available)

Paralogs for HSD17B14 Gene

Paralogs for HSD17B14 Gene

Selected SIMAP similar genes for HSD17B14 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HSD17B14: view

Variants for HSD17B14 Gene

Sequence variations from dbSNP and Humsavar for HSD17B14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs473464 -- 48,830,991(+) accac(C/T)acgcc intron-variant
rs482226 -- 48,818,719(-) cctgg(A/C)CCCCA intron-variant
rs485953 -- 48,818,318(-) ttttt(C/T)ttttt intron-variant
rs496961 -- 48,828,368(+) TTGGA(C/T)GGGTG intron-variant
rs507618 -- 48,832,362(+) CGACA(A/G)AGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B14 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv912245 CNV Loss 21882294
esv1431206 CNV Insertion 17803354
esv2431202 CNV Deletion 19546169
esv2718691 CNV Deletion 23290073
esv6750 CNV Loss 19470904
esv2718692 CNV Deletion 23290073

Relevant External Links for HSD17B14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B14 Gene

Disorders for HSD17B14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HSD17B14 Gene including...

Search for HSD17B14 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HSD17B14 Gene

Relevant External Links for HSD17B14

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with HSD17B14: view

No data available for UniProtKB/Swiss-Prot for HSD17B14 Gene

Publications for HSD17B14 Gene

  1. Short-chain dehydrogenases/reductases in retina. (PMID: 10800688) Haeseleer F. … Palczewski K. (Methods Enzymol. 2000) 2 3 4
  2. Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. (PMID: 17067289) Lukacik P. … Oppermann U. (Biochem. J. 2007) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3

Products for HSD17B14 Gene

Sources for HSD17B14 Gene

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