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Aliases for HSD17B13 Gene

Aliases for HSD17B13 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 13 2 3
  • SCDR9 3 4 6
  • Short Chain Dehydrogenase/Reductase Family 16C Member 3 3 4
  • Short-Chain Dehydrogenase/Reductase 9 3 4
  • 17-Beta-HSD 13 3 4
  • SDR16C3 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 3 3
  • Short Chain Dehydrogenase/Reductase Family 16C 2
  • 17-Beta-Hydroxysteroid Dehydrogenase 13 3
  • 17-Beta Hydroxysteroid Dehydrogenase 3
  • EC 1.1.-.- 4
  • Member 3 2
  • HMFN0376 3
  • NIIL497 3

External Ids for HSD17B13 Gene

Previous GeneCards Identifiers for HSD17B13 Gene

  • GC00U991221
  • GC04M088583
  • GC04M088443
  • GC04M088224
  • GC04M083970

Summaries for HSD17B13 Gene

GeneCards Summary for HSD17B13 Gene

HSD17B13 (Hydroxysteroid (17-Beta) Dehydrogenase 13) is a Protein Coding gene. Diseases associated with HSD17B13 include mucopolysaccharidosis iii and endometrial cancer. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is RDH10.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B13 Gene

Genomics for HSD17B13 Gene

Regulatory Elements for HSD17B13 Gene

Genomic Location for HSD17B13 Gene

Start:
87,303,789 bp from pter
End:
87,322,906 bp from pter
Size:
19,118 bases
Orientation:
Minus strand

Genomic View for HSD17B13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD17B13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD17B13 Gene

Proteins for HSD17B13 Gene

  • Protein details for HSD17B13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5P4-DHB13_HUMAN
    Recommended name:
    17-beta-hydroxysteroid dehydrogenase 13
    Protein Accession:
    Q7Z5P4
    Secondary Accessions:
    • A8K9R9
    • Q2M1L5
    • Q86W22
    • Q86W23

    Protein attributes for HSD17B13 Gene

    Size:
    300 amino acids
    Molecular mass:
    33655 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSD17B13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HSD17B13 Gene

Proteomics data for HSD17B13 Gene at MOPED

Post-translational modifications for HSD17B13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSD17B13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HSD17B13 Gene

Domains for HSD17B13 Gene

Gene Families for HSD17B13 Gene

HGNC:
  • SDRC3 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

Protein Domains for HSD17B13 Gene

Suggested Antigen Peptide Sequences for HSD17B13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5P4

UniProtKB/Swiss-Prot:

DHB13_HUMAN :
  • Q7Z5P4
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD17B13: view

Function for HSD17B13 Gene

Enzyme Numbers (IUBMB) for HSD17B13 Gene

Gene Ontology (GO) - Molecular Function for HSD17B13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSD17B13: view

Phenotypes for HSD17B13 Gene

GenomeRNAi human phenotypes for HSD17B13:
genes like me logo Genes that share phenotypes with HSD17B13: view

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSD17B13 Gene

Localization for HSD17B13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSD17B13 Gene COMPARTMENTS Subcellular localization image for HSD17B13 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSD17B13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0005811 lipid particle IDA 25028495
genes like me logo Genes that share ontologies with HSD17B13: view

Pathways for HSD17B13 Gene

SuperPathways for HSD17B13 Gene

No Data Available

Interacting Proteins for HSD17B13 Gene

Gene Ontology (GO) - Biological Process for HSD17B13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0046889 positive regulation of lipid biosynthetic process IDA 25028495
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD17B13: view

No data available for Pathways by source for HSD17B13 Gene

Compounds for HSD17B13 Gene

(44) Novoseek inferred chemical compound relationships for HSD17B13 Gene

Compound -log(P) Hits PubMed IDs
17beta-hydroxysteroid 98.6 167
estrone 88.2 26
3beta-hydroxysteroid 83.3 22
androstenedione 82.8 16
promegestone 80.7 2
genes like me logo Genes that share compounds with HSD17B13: view

Transcripts for HSD17B13 Gene

mRNA/cDNA for HSD17B13 Gene

Unigene Clusters for HSD17B13 Gene

Hydroxysteroid (17-beta) dehydrogenase 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B13 Gene

No ASD Table

Relevant External Links for HSD17B13 Gene

GeneLoc Exon Structure for
HSD17B13
ECgene alternative splicing isoforms for
HSD17B13

Expression for HSD17B13 Gene

mRNA expression in normal human tissues for HSD17B13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSD17B13 Gene

This gene is overexpressed in Liver (31.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSD17B13 Gene

SOURCE GeneReport for Unigene cluster for HSD17B13 Gene Hs.284414

mRNA Expression by UniProt/SwissProt for HSD17B13 Gene

Q7Z5P4-DHB13_HUMAN
Tissue specificity: Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.
genes like me logo Genes that share expressions with HSD17B13: view

Orthologs for HSD17B13 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD17B13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSD17B13 35
  • 99.11 (n)
  • 98.33 (a)
HSD17B13 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSD17B13 35
  • 86.9 (n)
  • 87.37 (a)
HSD17B13 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSD17B13 35
  • 86.08 (n)
  • 84.21 (a)
HSD17B13 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsd17b13 35
  • 80 (n)
  • 82.11 (a)
Hsd17b13 16
Hsd17b13 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hsd17b13 35
  • 81.05 (n)
  • 82.11 (a)
chicken
(Gallus gallus)
Aves SDR16C5 36
  • 44 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b13 35
  • 63.75 (n)
  • 63.87 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-7k24.6 36
  • 35 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15629 36
  • 32 (a)
ManyToMany
CG9265 36
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-29 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 20 (a)
ManyToMany
TDA5 36
  • 19 (a)
ManyToMany
TDA5 38
Species with no ortholog for HSD17B13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B13 Gene

ENSEMBL:
Gene Tree for HSD17B13 (if available)
TreeFam:
Gene Tree for HSD17B13 (if available)

Paralogs for HSD17B13 Gene

Paralogs for HSD17B13 Gene

Selected SIMAP similar genes for HSD17B13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD17B13: view

Variants for HSD17B13 Gene

Sequence variations from dbSNP and Humsavar for HSD17B13 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4305486 -- 87,303,325(+) ATGTA(C/T)GGTAT downstream-variant-500B
rs4693814 -- 87,308,430(+) ggatc(A/C)ccagg intron-variant
rs4693815 -- 87,315,947(+) ATATA(A/G)TTTTT intron-variant
rs6531970 -- 87,309,234(+) aaaaa(A/G)ttagt intron-variant
rs6531971 -- 87,309,340(+) gatca(C/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD17B13 Gene

Variant ID Type Subtype PubMed ID
nsv516203 CNV Loss 19592680
esv2667644 CNV Deletion 23128226
nsv470050 CNV Loss 18288195
nsv879527 CNV Loss 21882294
nsv525583 CNV Loss 19592680
nsv4412 CNV Loss 18451855
nsv293508 CNV Loss 16902084

Relevant External Links for HSD17B13 Gene

HapMap Linkage Disequilibrium report
HSD17B13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD17B13 Gene

Disorders for HSD17B13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for HSD17B13 Gene including...

Search for HSD17B13 Gene in MalaCards »

(16) Novoseek inferred disease relationships for HSD17B13 Gene

Disease -log(P) Hits PubMed IDs
pseudohermaphroditism male 64.1 5
virilization 57.5 5
benign meningioma 48.4 2
breast cancer 44.2 12
choriocarcinoma 38.1 4
genes like me logo Genes that share disorders with HSD17B13: view

No data available for UniProtKB/Swiss-Prot for HSD17B13 Gene

Publications for HSD17B13 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular cloning and expression analysis of a new gene for short- chain dehydrogenase/reductase 9. (PMID: 17311113) Liu S. … Yu L. (Acta Biochim. Pol. 2007) 3 4
  5. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 3

Products for HSD17B13 Gene

Sources for HSD17B13 Gene

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