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HSD17B11 Gene

protein-coding   GIFtS: 59
GCID: GC04M088257

Hydroxysteroid (17-Beta) Dehydrogenase 11

(Previous name: dehydrogenase/reductase (SDR family) member 8)
(Previous symbol: DHRS8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 111 2     Short Chain Dehydrogenase/Reductase Family 16C1
DHRS81 2 3     17-BETA-HSD112
Retinal Short-Chain Dehydrogenase/Reductase 21 2 3     17-BETA-HSDXI2
PAN1B2 3 5     17-Beta-Hydroxysteroid Dehydrogenase Type XI2
Dehydrogenase/Reductase (SDR Family) Member 81 2     17BHSD112
Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-032 3     SDR16C22
Dehydrogenase/Reductase SDR Family Member 82 3     CTCL Tumor Antigen HD-CL-032
17-Beta-HSD 112 3     Estradiol 17-Beta-Dehydrogenase 112
17-Beta-HSD XI2 3     Short Chain Dehydrogenase/Reductase Family 16C, Member 22
17-Beta-Hydroxysteroid Dehydrogenase 112 3     T-Cell Lymphoma-Associated Antigen HD-CL-032
17-Beta-Hydroxysteroid Dehydrogenase XI2 3     17bHSD113
CTCL-Associated Antigen HD-CL-032 3     17betaHSD113
EC 1.1.1.623 8     17betaHSDXI3
RETSDR22 5     retSDR23
Member 21     EC 1.1.18

External Ids:    HGNC: 229601   Entrez Gene: 511702   Ensembl: ENSG000001981897   OMIM: 6128315   UniProtKB: Q8NBQ53   

Export aliases for HSD17B11 gene to outside databases

Previous GC identifers: GC04M088477 GC04M084003


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HSD17B11 Gene:
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al.,
2001 (PubMed 11165019)).(supplied by OMIM, Jun 2009)

GeneCards Summary for HSD17B11 Gene:
HSD17B11 (hydroxysteroid (17-beta) dehydrogenase 11) is a protein-coding gene. Diseases associated with HSD17B11 include cutaneous t cell lymphoma, and retinitis. GO annotations related to this gene include steroid dehydrogenase activity and estradiol 17-beta-dehydrogenase activity. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it
may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate
steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA
(dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to
A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma

Gene Wiki entry for HSD17B11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSD17B11 gene promoter:
         SRF   ISGF-3   AML1a   SRF (504 AA)   CREB   PPAR-alpha   SRY   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD17B11 promoter sequence
   Search Chromatin IP Primers for HSD17B11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSD17B11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

HSD17B11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M088257:  view genomic region     (about GC identifiers)

Start:
88,257,691 bp from pter      End:
88,312,538 bp from pter
Size:
54,848 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5 (See protein sequence)
Recommended Name: Estradiol 17-beta-dehydrogenase 11 precursor  
Size: 300 amino acids; 32936 Da
1 PDB 3D structure from and Proteopedia for HSD17B11:
1YB1 (3D)    
Secondary accessions: Q96HF6 Q9UKU4

Explore the universe of human proteins at neXtProt for HSD17B11: NX_Q8NBQ5

Explore proteomics data for HSD17B11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HSD17B11 (Q8NBQ5) (see all 6)
     VLITGAG  TTKAFLP  VTVASAAGH  NTGFIKNPST 


    See HSD17B11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057329.2  
    ENSEMBL proteins: 
     ENSP00000351035   ENSP00000423775  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8NBQ5

    ProtoNet protein and cluster: Q8NBQ5

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily


    HSD17B11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHB11_HUMAN, Q8NBQ5
    Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it
    may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate
    steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA
    (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to
    A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma
    Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H

         Enzyme Numbers (IUBMB): EC 1.1.1.621 2 EC 1.1.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004303estradiol 17-beta-dehydrogenase activity IEA--
    GO:0016229steroid dehydrogenase activity IDA12697717
    GO:0016491oxidoreductase activity ----
         
    HSD17B11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSD17B11:
     Decreased number of cells in m  Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hsd17b11):
     hematopoietic system  immune system 

    HSD17B11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSD17B11
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    6 qRT-PCR Assays for microRNAs that regulate HSD17B11:
    hsa-miR-4261 hsa-miR-4289 hsa-miR-205 hsa-miR-1303 hsa-miR-202 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DHB11_HUMAN, Q8NBQ5: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    endoplasmic reticulum2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA12697717
    GO:0005811lipid particle IDA14741744

    HSD17B11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSD17B11 About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of steroid hormone biosynthesis
    superpathway of steroid hormone biosynthesis
    estradiol biosynthesis I0.00


    2 BioSystems Pathways for HSD17B11
        superpathway of steroid hormone biosynthesis
    estradiol biosynthesis I



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSD17B11
    Interactions:

        Search GeneGlobe Interaction Network for HSD17B11

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for HSD17B11 (Q8NBQ53 ENSP000003510354) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    GSTK1Q9Y2Q33I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process IEA--
    GO:0006710androgen catabolic process IDA12697717
    GO:0008152metabolic process ----

    HSD17B11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSD17B11 (DHB11)

    4 HMDB Compounds for HSD17B11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    1 DrugBank Compound for HSD17B11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aetiocholanolone-- 53-42-9target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSD17B11 gene: 
    NM_016245.3  

    Unigene Cluster for HSD17B11:

    Hydroxysteroid (17-beta) dehydrogenase 11
    Hs.594923  [show with all ESTs]
    Unigene Representative Sequence: NM_016245
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358290(uc003hqp.2) ENST00000507518 ENST00000512344 ENST00000502576
    ENST00000507286 ENST00000513854 ENST00000508413
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate HSD17B11:
    hsa-miR-4261 hsa-miR-4289 hsa-miR-205 hsa-miR-1303 hsa-miR-202 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B11 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat HSD17B11
      QuantiFast Probe-based Assays in human, mouse, rat HSD17B11

    Additional mRNA sequence: 

    AF126780.1 AF273056.1 AK075348.1 AY358553.1 BC008650.1 BC011995.1 BC014327.1 BC016367.1 
    BC021673.1 BC036001.1 

    13 DOTS entries:

    DT.115882  DT.99986563  DT.100810454  DT.97845250  DT.121266831  DT.121266861  DT.121266867  DT.121266876 
    DT.95327715  DT.100029823  DT.40215765  DT.65285290  DT.75102880 

    Selected AceView cDNA sequences (see all 289):

    BQ025864 CA775960 AW339053 AA292418 AB073347 AL558393 BE465545 AI193508 
    CR590939 CA842996 AW193089 AA481674 BQ270992 BM843043 AI685119 CR598640 
    AA902413 AW051074 AA481670 CR607201 NM_178135 BM664111 BQ773411 AW273624 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSD17B11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCTCAAT
    HSD17B11 Expression
    About this image


    HSD17B11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    HSD17B11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSD17B11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.594923

    UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
    Tissue specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland,
    Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the
    ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected
    in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina
    (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small
    intestine, ovary and heart

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSD17B11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsd17b111 , 5 hydroxysteroid (17-beta) dehydrogenase 111, 5 78.97(n)1
    83.22(a)1
      5 (50.52 cM)5
    1146641  NM_053262.31  NP_444492.11 
     1039897625 
    chicken
    (Gallus gallus)
    Aves HSD17B111 hydroxysteroid (17-beta) dehydrogenase 11 65.82(n)
    67.03(a)
      422588  XM_420547.3  XP_420547.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    many ↔ many
    4(146455902-146466690)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hsd17b111 hydroxysteroid (17-beta) dehydrogenase 11 66.3(n)
    63(a)
      496757  NM_001011304.1  NP_001011304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sdr16c5a6
    short chain dehydrogenase/reductase family 16C, me...
    47(a)
    many ↔ many
    2(11274377-11295652) ENSDARG00000016233
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156296
    CG92656
    --
    32(a)
    29(a)
    many ↔ many
    many ↔ many
    2L(4813009-4815891)
    2L(21057706-21071502)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-296
    Protein DHS-29 (dhs-29) mRNA, complete cds
    21(a)
    many ↔ many
    X(7661902-7664914) WBGene00000992
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YDL114W)4 Putative protein of unknown function with similarity more   --   4(255604-256530) 851444  NP_010169.1 


    ENSEMBL Gene Tree for HSD17B11 (if available)
    TreeFam Gene Tree for HSD17B11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HSD17B11 gene
    HSD17B132  RDH102  DHRS32  SDR16C52  
    4 SIMAP similar genes for HSD17B11 using alignment to 2 protein entries:     DHB11_HUMAN (see all proteins):
    HSD17B13    DHRS3    RDH10    SDR16C5

    HSD17B11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSD17B11 (see all 1359)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116499221,2
    C,F--88257233(+) CCACAC/ACCAGC 1 -- ds50011Minor allele frequency- A:0.12NA 120
    rs1132890331,2
    C,F--88257248(+) GTTTGT/GGGATT 1 -- ds50012Minor allele frequency- G:0.28CSA WA 120
    rs1117801791,2
    C,F--88257341(+) AATCAT/GCCGCC 1 -- ds50012Minor allele frequency- G:0.30CSA WA 120
    rs1402217571,2
    C--88257347(+) CCGCCC/TGCCTT 1 -- ds50010--------
    rs1127761531,2
    C,F--88257436(+) GAGATG/AGAGTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1884503111,2
    --88257440(+) TGGAGC/TTTCAC 1 -- ds50010--------
    rs1449028491,2
    --88257525(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1134280081,2
    C,F--88257597(+) AACAAG/ACCTAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs576009151,2
    C--88257720(+) AGGTTAA/-GTCAT 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1461692581,2
    C--88257772(+) GTGTGA/GTCCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HSD17B11 (88257691 - 88312538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HSD17B11 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2559237CNV Deletion19546169
    nsv436424CNV Deletion17901297
    esv2665467CNV Deletion23128226
    esv2727938CNV Deletion23290073
    esv2000200CNV Deletion18987734
    esv2057903CNV Deletion18987734
    esv1410990CNV Deletion17803354
    esv2727939CNV Deletion23290073
    nsv499051CNV Loss21111241
    nsv4412CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSD17B11
    DNA2.0 Custom Variant and Variant Library Synthesis for HSD17B11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612831    OMIM disorders: --

    8 diseases for HSD17B11:    
    About MalaCards
    cutaneous t cell lymphoma    retinitis    bronchiolitis    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    tuberculosis    prostate cancer    prostatitis


    HSD17B11 for disorders           About GeneDecksing


    Export disorders for HSD17B11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSD17B11 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with HSD17B11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. (PubMed id 12697717)1, 2, 3, 9 Chai Z.... Krozowski Z. (Endocrinology 2003)
    2. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. (PubMed id 11165019)1, 2, 3 Brereton P.... Krozowski Z. (Mol. Cell. Endocrinol. 2001)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (Chem. Biol. Interact. 2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095)1, 2 Hartmann T.B.... Eichmueller S. (Br. J. Dermatol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Short-chain dehydrogenases/reductases in retina. (PubMed id 10800688)1, 2 Haeseleer F. and Palczewski K. (Methods Enzymol. 2000)
    9. Cloning and expression of a novel tissue specific 17beta- hydroxysteroid dehydrogenase. (PubMed id 9888557)1, 2 Li K.X.Z.... Krozowski Z.S. (Endocr. Res. 1998)
    10. 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. (PubMed id 19469652)1, 9 Nakamura Y....Sasano H. (Neoplasma 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51170 HGNC: 22960 AceView: DHRS8andSCDR9 Ensembl:ENSG00000198189 euGenes: HUgn51170
    ECgene: HSD17B11 H-InvDB: HSD17B11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSD17B11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSD17B11 gene:
    Search GeneIP for patents involving HSD17B11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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