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Aliases for HSD17B11 Gene

Aliases for HSD17B11 Gene

  • Hydroxysteroid (17-Beta) Dehydrogenase 11 2 3
  • Retinal Short-Chain Dehydrogenase/Reductase 2 2 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C Member 2 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-03 3 4
  • Dehydrogenase/Reductase SDR Family Member 8 3 4
  • CTCL-Associated Antigen HD-CL-03 3 4
  • EC 1.1.1.62 4 63
  • 17BHSD11 3 4
  • RETSDR2 3 4
  • SDR16C2 3 4
  • DHRS8 3 4
  • PAN1B 3 4
  • Short Chain Dehydrogenase/Reductase Family 16C, Member 2 3
  • Short Chain Dehydrogenase/Reductase Family 16C 2
  • Dehydrogenase/Reductase (SDR Family) Member 8 2
  • 17-Beta-Hydroxysteroid Dehydrogenase Type XI 3
  • 17-Beta-Hydroxysteroid Dehydrogenase 11 4
  • 17-Beta-Hydroxysteroid Dehydrogenase XI 4
  • CTCL Tumor Antigen HD-CL-03 3
  • 17-Beta-HSD 11 4
  • 17-Beta-HSD XI 4
  • 17-BETA-HSD11 3
  • 17-BETA-HSDXI 3
  • 17betaHSD11 4
  • 17betaHSDXI 4
  • Member 2 2
  • EC 1.1.1 63

External Ids for HSD17B11 Gene

Previous HGNC Symbols for HSD17B11 Gene

  • DHRS8

Previous GeneCards Identifiers for HSD17B11 Gene

  • GC04M088477
  • GC04M088257
  • GC04M084003

Summaries for HSD17B11 Gene

Entrez Gene Summary for HSD17B11 Gene

  • Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009]

GeneCards Summary for HSD17B11 Gene

HSD17B11 (Hydroxysteroid (17-Beta) Dehydrogenase 11) is a Protein Coding gene. Diseases associated with HSD17B11 include cutaneous t cell lymphoma. Among its related pathways are Metabolism and Metabolism of steroid hormones and vitamin D. GO annotations related to this gene include oxidoreductase activity and steroid dehydrogenase activity. An important paralog of this gene is RDH10.

UniProtKB/Swiss-Prot for HSD17B11 Gene

  • Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma

Gene Wiki entry for HSD17B11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD17B11 Gene

Genomics for HSD17B11 Gene

Regulatory Elements for HSD17B11 Gene

Genomic Location for HSD17B11 Gene

Chromosome:
4
Start:
87,336,522 bp from pter
End:
87,391,386 bp from pter
Size:
54,865 bases
Orientation:
Minus strand

Genomic View for HSD17B11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD17B11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD17B11 Gene

Proteins for HSD17B11 Gene

  • Protein details for HSD17B11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBQ5-DHB11_HUMAN
    Recommended name:
    Estradiol 17-beta-dehydrogenase 11
    Protein Accession:
    Q8NBQ5
    Secondary Accessions:
    • Q96HF6
    • Q9UKU4

    Protein attributes for HSD17B11 Gene

    Size:
    300 amino acids
    Molecular mass:
    32936 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HSD17B11 Gene

neXtProt entry for HSD17B11 Gene

Proteomics data for HSD17B11 Gene at MOPED

Selected DME Specific Peptides for HSD17B11 Gene

Post-translational modifications for HSD17B11 Gene

  • Ubiquitination at Lys 62
  • Modification sites at PhosphoSitePlus

Other Protein References for HSD17B11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HSD17B11 Gene

Gene Families for HSD17B11 Gene

Suggested Antigen Peptide Sequences for HSD17B11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NBQ5

UniProtKB/Swiss-Prot:

DHB11_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
genes like me logo Genes that share domains with HSD17B11: view

Function for HSD17B11 Gene

Molecular function for HSD17B11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma

Enzyme Numbers (IUBMB) for HSD17B11 Gene

Gene Ontology (GO) - Molecular Function for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004303 estradiol 17-beta-dehydrogenase activity IEA --
GO:0016229 steroid dehydrogenase activity IDA 12697717
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with HSD17B11: view
genes like me logo Genes that share phenotypes with HSD17B11: view

Animal Model Products

miRNA for HSD17B11 Gene

miRTarBase miRNAs that target HSD17B11

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSD17B11

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HSD17B11 Gene

Localization for HSD17B11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD17B11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSD17B11 Gene COMPARTMENTS Subcellular localization image for HSD17B11 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA 12697717
GO:0005811 lipid particle IDA 14741744
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HSD17B11: view

Pathways & Interactions for HSD17B11 Gene

genes like me logo Genes that share pathways with HSD17B11: view

Pathways by source for HSD17B11 Gene

Gene Ontology (GO) - Biological Process for HSD17B11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process --
GO:0006703 estrogen biosynthetic process TAS --
GO:0006710 androgen catabolic process IDA 12697717
GO:0008152 metabolic process --
GO:0008202 steroid metabolic process TAS --
genes like me logo Genes that share ontologies with HSD17B11: view

No data available for SIGNOR curated interactions for HSD17B11 Gene

Drugs & Compounds for HSD17B11 Gene

(5) Drugs for HSD17B11 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estradiol Approved, Investigational Pharma Sex hormone 1057
Estrone Approved Pharma Agonist Estrogenic hormone 18
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Etiocholanolone Experimental Pharma Target 0
NAD Pharma Agonist, Activator 0
genes like me logo Genes that share compounds with HSD17B11: view

Transcripts for HSD17B11 Gene

Unigene Clusters for HSD17B11 Gene

Hydroxysteroid (17-beta) dehydrogenase 11:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSD17B11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD17B11 Gene

No ASD Table

Relevant External Links for HSD17B11 Gene

GeneLoc Exon Structure for
HSD17B11
ECgene alternative splicing isoforms for
HSD17B11

Expression for HSD17B11 Gene

mRNA expression in normal human tissues for HSD17B11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSD17B11 Gene

This gene is overexpressed in Whole Blood (x7.8).

Protein differential expression in normal tissues from HIPED for HSD17B11 Gene

This gene is overexpressed in Fetal Liver (10.3), Nasal epithelium (8.5), and Liver (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSD17B11 Gene



SOURCE GeneReport for Unigene cluster for HSD17B11 Gene Hs.594923

mRNA Expression by UniProt/SwissProt for HSD17B11 Gene

Q8NBQ5-DHB11_HUMAN
Tissue specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.
genes like me logo Genes that share expression patterns with HSD17B11: view

Protein tissue co-expression partners for HSD17B11 Gene

Primer Products

In Situ Assay Products

Orthologs for HSD17B11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD17B11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSD17B11 35
  • 87.44 (n)
  • 83.33 (a)
HSD17B11 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSD17B11 35
  • 88.22 (n)
  • 84.67 (a)
mouse
(Mus musculus)
Mammalia Hsd17b11 35
  • 78.97 (n)
  • 83.22 (a)
Hsd17b11 16
Hsd17b11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSD17B11 35
  • 99.44 (n)
  • 99.67 (a)
HSD17B11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hsd17b11 35
  • 77.96 (n)
  • 81.54 (a)
oppossum
(Monodelphis domestica)
Mammalia HSD17B11 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSD17B11 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSD17B11 35
  • 65.82 (n)
  • 67.03 (a)
-- 36
  • 60 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd17b11 35
  • 66.3 (n)
  • 63 (a)
zebrafish
(Danio rerio)
Actinopterygii sdr16c5a 36
  • 47 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15629 36
  • 32 (a)
ManyToMany
CG9265 36
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dhs-29 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 19 (a)
ManyToMany
TDA5 36
  • 17 (a)
ManyToMany
-- 38
Species with no ortholog for HSD17B11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSD17B11 Gene

ENSEMBL:
Gene Tree for HSD17B11 (if available)
TreeFam:
Gene Tree for HSD17B11 (if available)

Paralogs for HSD17B11 Gene

Paralogs for HSD17B11 Gene

(4) SIMAP similar genes for HSD17B11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HSD17B11: view

Variants for HSD17B11 Gene

Structural Variations from Database of Genomic Variants (DGV) for HSD17B11 Gene

Variant ID Type Subtype PubMed ID
nsv4412 CNV Loss 18451855
esv2559237 CNV Deletion 19546169
nsv436424 CNV Deletion 17901297
nsv513144 CNV Loss 21212237
esv2000200 CNV Deletion 18987734
esv2665467 CNV Deletion 23128226
nsv499051 CNV Loss 21111241
esv2727938 CNV Deletion 23290073
nsv293528 CNV Loss 16902084
esv2057903 CNV Deletion 18987734
esv2727939 CNV Deletion 23290073
esv1410990 CNV Deletion 17803354

Variation tolerance for HSD17B11 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSD17B11 Gene

HapMap Linkage Disequilibrium report
HSD17B11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HSD17B11 Gene

Disorders for HSD17B11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HSD17B11 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
- elite association

Relevant External Links for HSD17B11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSD17B11
genes like me logo Genes that share disorders with HSD17B11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HSD17B11 Gene

Publications for HSD17B11 Gene

  1. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. (PMID: 12697717) Chai Z. … Krozowski Z. (Endocrinology 2003) 2 23 67
  2. 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. (PMID: 19469652) Nakamura Y. … Sasano H. (Neoplasma 2009) 23 67
  3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PMID: 19027726) Persson B. … Oppermann U. (Chem. Biol. Interact. 2009) 2 67
  4. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. (PMID: 11165019) Brereton P. … Krozowski Z. (Mol. Cell. Endocrinol. 2001) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for HSD17B11 Gene

Sources for HSD17B11 Gene

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