Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSD17B11 Gene

protein-coding   GIFtS: 58
GCID: GC04M088257

Hydroxysteroid (17-Beta) Dehydrogenase 11

(Previous name: dehydrogenase/reductase (SDR family) member 8)
(Previous symbol: DHRS8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hydroxysteroid (17-Beta) Dehydrogenase 111 2     Short Chain Dehydrogenase/Reductase Family 16C1
DHRS81 2 3     17-BETA-HSD112
Retinal Short-Chain Dehydrogenase/Reductase 21 2 3     17-BETA-HSDXI2
PAN1B2 3 5     17-Beta-Hydroxysteroid Dehydrogenase Type XI2
Dehydrogenase/Reductase (SDR Family) Member 81 2     17BHSD112
Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-032 3     SDR16C22
Dehydrogenase/Reductase SDR Family Member 82 3     CTCL Tumor Antigen HD-CL-032
17-Beta-HSD 112 3     Estradiol 17-Beta-Dehydrogenase 112
17-Beta-HSD XI2 3     Short Chain Dehydrogenase/Reductase Family 16C, Member 22
17-Beta-Hydroxysteroid Dehydrogenase 112 3     T-Cell Lymphoma-Associated Antigen HD-CL-032
17-Beta-Hydroxysteroid Dehydrogenase XI2 3     17bHSD113
CTCL-Associated Antigen HD-CL-032 3     17betaHSD113
EC 1.1.1.623 8     17betaHSDXI3
RETSDR22 5     retSDR23
Member 21     EC 1.1.18

External Ids:    HGNC: 229601   Entrez Gene: 511702   Ensembl: ENSG000001981897   OMIM: 6128315   UniProtKB: Q8NBQ53   

Export aliases for HSD17B11 gene to outside databases

Previous GC identifers: GC04M088477 GC04M084003


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSD17B11 Gene:
Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al.,
2001 (PubMed 11165019)).(supplied by OMIM, Jun 2009)

GeneCards Summary for HSD17B11 Gene: 
HSD17B11 (hydroxysteroid (17-beta) dehydrogenase 11) is a protein-coding gene. Diseases associated with HSD17B11 include cutaneous t cell lymphoma, and alcoholism. GO annotations related to this gene include steroid dehydrogenase activity and nucleotide binding. An important paralog of this gene is HSD17B13.

UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it
may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate
steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA
(dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to
A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma

Gene Wiki entry for HSD17B11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSD17B11 gene promoter:
         SRF   ISGF-3   AML1a   SRF (504 AA)   CREB   PPAR-alpha   SRY   deltaCREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD17B11 promoter sequence
   Search SABiosciences Chromatin IP Primers for HSD17B11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

HSD17B11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD17B11 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M088257:  view genomic region     (about GC identifiers)

Start:
88,257,691 bp from pter      End:
88,312,538 bp from pter
Size:
54,848 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5 (See protein sequence)
Recommended Name: Estradiol 17-beta-dehydrogenase 11 precursor  
Size: 300 amino acids; 32936 Da
Subcellular location: Secreted (Potential)
1 PDB 3D structure from and Proteopedia for HSD17B11:
1YB1 (3D)    
Secondary accessions: Q96HF6 Q9UKU4

Explore the universe of human proteins at neXtProt for HSD17B11: NX_Q8NBQ5

Explore proteomics data for HSD17B11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NBQ5

  • 4/6 DME Specific Peptides for HSD17B11 (Q8NBQ5) (see all 6)
     VLITGAG  TTKAFLP  VTVASAAGH  NTGFIKNPST 

    HSD17B11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HSD17B11 Protein Expression
    REFSEQ proteins: NP_057329.2  
    ENSEMBL proteins: 
     ENSP00000351035   ENSP00000423775  

    Human Recombinant Protein Products for HSD17B11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HSD17B11
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for HSD17B11 
    OriGene Custom Protein Services for HSD17B11
    GenScript Custom Purified and Recombinant Proteins Services for HSD17B11
    Novus Biologicals HSD17B11 Proteins
    Novus Biologicals HSD17B11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HSD17B11
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IDA12697717
    GO:0005811lipid particle IDA14741744

    HSD17B11 for ontologies           About GeneDecksing



    HSD17B11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSD17B11
    GenScript Custom Superior Antibodies Services for HSD17B11
    Novus Biologicals HSD17B11 Antibodies
    Abcam antibodies for HSD17B11
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for HSD17B11
    LSBio Antibodies in human, mouse, rat for HSD17B11 

    Assay Products for HSD17B11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HSD17B11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSD17B11
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SDRC3: Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

    3 InterPro protein domains:
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q8NBQ5

    ProtoNet protein and cluster: Q8NBQ5

    2 Blocks protein domains:
    IPB002198 Short-chain dehydrogenase/reductase SDR
    IPB002347 Glucose/ribitol dehydrogenase family signature


    UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily


    HSD17B11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHB11_HUMAN, Q8NBQ5
    Function: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it
    may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate
    steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA
    (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to
    A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma
    Catalytic activity: 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H

         Enzyme Numbers (IUBMB): EC 1.1.1.621 2 EC 1.1.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004303estradiol 17-beta-dehydrogenase activity IEA--
    GO:0016229steroid dehydrogenase activity IDA12697717
    GO:0016491oxidoreductase activity ----
         
    HSD17B11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HSD17B11:
     Decreased number of cells in m  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hsd17b11):
     cellular  hematopoietic system  immune system 

    HSD17B11 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HSD17B11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSD17B11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSD17B11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSD17B11 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD17B11
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HSD17B11:
    hsa-miR-4261 hsa-miR-4289 hsa-miR-205 hsa-miR-1303 hsa-miR-202 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B11 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSD17B11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSD17B11
    Sirion Biotech Customized adenovirus for overexpression of HSD17B11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HSD17B11 (see all 8)
    OriGene ORF clones in mouse, rat for HSD17B11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSD17B11 (NM_016245)
    Sino Biological Human cDNA Clone for HSD17B11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B11
    Sirion Biotech Customized lentivirus for stable overexpression of HSD17B11 
                         Customized lentivirus expression plasmids for stable overexpression of HSD17B11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSD17B11
    Search LifeMap BioReagents cell lines for HSD17B11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HSD17B11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1estrogen biosynthesis
    estrogen biosynthesis


    1 BioSystems Pathway for HSD17B11
        estrogen biosynthesis



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSD17B11

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for HSD17B11 (Q8NBQ53 ENSP000003510354) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRF2Q9HAW03, ENSP000002206594I2D: score=1 STRING: ENSP00000220659
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    GSTK1Q9Y2Q33I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006694steroid biosynthetic process IEA--
    GO:0006710androgen catabolic process IDA12697717
    GO:0008152metabolic process ----

    HSD17B11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSD17B11 (DHB11)

    4 HMDB Compounds for HSD17B11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Estradiol(+)-3,17b-Estradiol (see all 83)50-28-2--
    Estrone(+)-Estrone (see all 7)53-16-7--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    1 DrugBank Compound for HSD17B11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Aetiocholanolone-- 53-42-9target--10592235

    Search CenterWatch for drugs/clinical trials and news about HSD17B11 / DHB11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSD17B11 gene: 
    NM_016245.3  

    Unigene Cluster for HSD17B11:

    Hydroxysteroid (17-beta) dehydrogenase 11
    Hs.594923  [show with all ESTs]
    Unigene Representative Sequence: NM_016245
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358290(uc003hqp.2) ENST00000507518 ENST00000512344 ENST00000502576
    ENST00000507286 ENST00000513854 ENST00000508413
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD17B11
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HSD17B11:
    hsa-miR-4261 hsa-miR-4289 hsa-miR-205 hsa-miR-1303 hsa-miR-202 hsa-miR-518a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHSD17B11 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HSD17B11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B11
    Clone
    Products:
         
    OriGene clones in human, mouse for HSD17B11 (see all 8)
    OriGene ORF clones in mouse, rat for HSD17B11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HSD17B11 (NM_016245)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B11
    Sirion Biotech Customized lentivirus for stable overexpression of HSD17B11 
                         Customized lentivirus expression plasmids for stable overexpression of HSD17B11 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HSD17B11
    OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSD17B11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B11

    Additional mRNA sequence: 

    AF126780.1 AF273056.1 AK075348.1 AY358553.1 BC008650.1 BC011995.1 BC014327.1 BC016367.1 
    BC021673.1 BC036001.1 

    13 DOTS entries:

    DT.115882  DT.99986563  DT.100810454  DT.97845250  DT.121266831  DT.121266861  DT.121266867  DT.121266876 
    DT.95327715  DT.100029823  DT.40215765  DT.65285290  DT.75102880 

    24/289 AceView cDNA sequences (see all 289):

    AW337877 CA842996 BM843043 CR602713 AI678575 AA576473 AI685119 AA292418 
    NM_178135 AI193508 AA577610 AL558393 BQ025864 BU633600 CA775960 AY358575 
    CR590939 AA481674 BM664111 CR603100 AB073347 BE465545 AA485827 CR607201 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSD17B11 expression in normal human tissues (normalized intensities)      HSD17B11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCTCAAT
    HSD17B11 Expression
    About this image


    HSD17B11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle

    See HSD17B11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSD17B11

    SOURCE GeneReport for Unigene cluster: Hs.594923

    UniProtKB/Swiss-Prot: DHB11_HUMAN, Q8NBQ5
    Tissue specificity: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland,
    Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the
    ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected
    in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina
    (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small
    intestine, ovary and heart

        SABiosciences Custom PCR Arrays for HSD17B11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HSD17B11
    OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSD17B11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HSD17B11 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hsd17b111 , 5 hydroxysteroid (17-beta) dehydrogenase 111, 5 78.97(n)1
    83.22(a)1
      5 (50.52 cM)5
    1146641  NM_053262.31  NP_444492.11 
     1039897625 
    chicken
    (Gallus gallus)
    Aves HSD17B111 hydroxysteroid (17-beta) dehydrogenase 11 64.83(n)
    64.95(a)
      422588  XM_420547.2  XP_420547.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSD17B116
    hydroxysteroid (17-beta) dehydrogenase 11
    56(a)
    1 ↔ 1
    5(45282097-45293148)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG156296
    CG149466
    (see all 6)
    --
    32(a)
    31(a)
    (see all 6)
    many ↔ many
    possible ortholog
    (see all 6)
    2L(4813009-4815891)
    2L(12063523-12066772)
    worm
    (Caenorhabditis elegans)
    Secernentea dhs-296
    Protein DHS-29
    22(a)
    possible ortholog
    X(7661902-7664914)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YDL114W)4 Putative protein of unknown function with similarity more   --   4(255604-256530) 851444  NP_010169.1 


    ENSEMBL Gene Tree for HSD17B11 (if available)
    TreeFam Gene Tree for HSD17B11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSD17B11 gene
    HSD17B132  RDH102  DHRS32  SDR16C52  
    4 SIMAP similar genes for HSD17B11 using alignment to 2 protein entries:     DHB11_HUMAN (see all proteins):
    HSD17B13    DHRS3    RDH10    SDR16C5

    HSD17B11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1359 SNPs in HSD17B11 are shown (see all 1359)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1116499221,2
    C,F--88257233(+) CCACAC/ACCAGC 1 -- ds50011Minor allele frequency- A:0.12NA 120
    rs1132890331,2
    C,F--88257248(+) GTTTGT/GGGATT 1 -- ds50012Minor allele frequency- G:0.28CSA WA 120
    rs1117801791,2
    C,F--88257341(+) AATCAT/GCCGCC 1 -- ds50012Minor allele frequency- G:0.30CSA WA 120
    rs1402217571,2
    C--88257347(+) CCGCCC/TGCCTT 1 -- ds50010--------
    rs1127761531,2
    C,F--88257436(+) GAGATG/AGAGTT 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1884503111,2
    --88257440(+) TGGAGC/TTTCAC 1 -- ds50010--------
    rs1449028491,2
    --88257525(+) CAGGCA/GTGAGC 1 -- ds50010--------
    rs1134280081,2
    C,F--88257597(+) AACAAG/ACCTAC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs576009151,2
    C--88257720(+) AGGTTAA/-GTCAT 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs1461692581,2
    C--88257772(+) GTGTGA/GTCCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HSD17B11 (88257691 - 88312538 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for HSD17B11 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2559237CNV Deletion19546169
    nsv436424CNV Deletion17901297
    esv2665467CNV Deletion23128226
    esv2727938CNV Deletion23290073
    esv2000200CNV Deletion18987734
    esv2057903CNV Deletion18987734
    esv1410990CNV Deletion17803354
    esv2727939CNV Deletion23290073
    nsv499051CNV Loss21111241
    nsv4412CNV Loss18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HSD17B11
    DNA2.0 Custom Variant and Variant Library Synthesis for HSD17B11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612831    OMIM disorders: --

    9 diseases for HSD17B11:    About MalaCards
    cutaneous t cell lymphoma    alcoholism    retinitis    bronchiolitis
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    tuberculosis    prostate cancer
    prostatitis


    HSD17B11 for disorders           About GeneDecksing


    Export disorders for HSD17B11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSD17B11 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with HSD17B11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells. (PubMed id 12697717)1, 2, 3, 9 Chai Z....Krozowski Z. (2003)
    2. Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. (PubMed id 11165019)1, 2, 3 Brereton P.... Krozowski Z. (2001)
    3. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095)1, 2 Hartmann T.B.... Eichmueller S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Short-chain dehydrogenases/reductases in retina. (PubMed id 10800688)1, 2 Haeseleer F. and Palczewski K. (2000)
    9. Cloning and expression of a novel tissue specific 17beta- hydroxysteroid dehydrogenase. (PubMed id 9888557)1, 2 Li K.X.Z.... Krozowski Z.S. (1998)
    10. 17beta-hydroxysteroid dehydrogenase type 11 (Pan1b) expression in human prostate cancer. (PubMed id 19469652)1, 9 Nakamura Y....Sasano H. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51170 HGNC: 22960 AceView: DHRS8andSCDR9 Ensembl:ENSG00000198189 euGenes: HUgn51170
    ECgene: HSD17B11 H-InvDB: HSD17B11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSD17B11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSD17B11 gene:
    Search GeneIP for patents involving HSD17B11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HSD17B11  
     OriGene qPCR primer pairs and template standards for HSD17B11   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for HSD17B11   OriGene clones in human, mouse for HSD17B11  
     OriGene qSTAR qPCR primer pairs in human, mouse for HSD17B11   OriGene Purified Protein for HSD17B11  
     OriGene ORF clones in mouse, rat for HSD17B11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSD17B11   OriGene Custom Protein Services for HSD17B11  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSD17B11
     QIAGEN SeqTarget long-range PCR primers for resequencing HSD17B11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD17B11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B11
     GenScript Custom Purified and Recombinant Proteins Services for HSD17B11 GenScript cDNA clones with any tag delivered in your preferred vector for HSD17B11
     GenScript Custom Assay Services for HSD17B11 GenScript Custom Superior Antibodies Services for HSD17B11
     GenScript Custom overexpressing Cell Line Services for HSD17B11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSD17B11 promoter
     Search Chromatin IP Primers for HSD17B11
     RT2 qPCR Primer Assay in human, mouse, rat HSD17B11
     Search GNC Networks for HSD17B11
     SABiosciences Custom PCR Arrays for HSD17B11
     Search Tocris compounds for HSD17B11 (DHB11)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for HSD17B11
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSD17B11 antibodies
     HSD17B11 proteins
     HSD17B11 lysates
     Antibodies for HSD17B11
     See all of Abcam's Antibodies, Kits and Proteins for HSD17B11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HSD17B11




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HSD17B11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B11
     SwitchGear 3'UTR luciferase reporter plasmids for HSD17B11
     SwitchGear Promoter luciferase reporter plasmids for HSD17B11
     ThermoFisher Antibodies for HSD17B11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HSD17B11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HSD17B11
    Customized:
     lentivirus for stable overexpression of HSD17B11
     lentivirus expression plasmids for stable overexpression of HSD17B11
     adenovirus for overexpression of HSD17B11
     LSBio Antibodies in human, mouse, rat for HSD17B11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSD17B11 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4