HSD17B1 Gene

Aliases
for HSD17B1 gene

Previous GC identifers: GC17P040268 GC17P042872 GC17P040612 GC17P041077 GC17P041074 GC17P037954 GC17P036468

Summaries
for HSD17B1 gene

Genomic Views
for HSD17B1 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmid: HSD17B1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD17B1

HSD17B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040701:  view genomic region     (about GC identifiers)

Proteins
for HSD17B1 gene

6/22 PDB 3D structures from and Proteopedia for HSD17B1 (see all 22):

1A27 (3D)        1BHS (3D)        1DHT (3D)        1EQU (3D)        1FDS (3D)        1FDT (3D)    

Explore the universe of human proteins at neXtProt for HSD17B1: NX_P14061

HSD17B1 Protein expression data from MOPED and PaxDb:    About this image 

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals HSD17B1 Protein
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for HSD17B1 (17 beta-HSD1/HSD17B1)
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	GenScript Custom Superior Antibodies Services for HSD17B1
	Novus Biologicals HSD17B1 Antibodies
	Abcam antibodies for HSD17B1
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for HSD17B1

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for HSD17B1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for HSD17B1 gene

ProtoNet protein and cluster: P14061

Function
for HSD17B1 gene

miRNA Products:		OriGene 3'-UTR Clone: HSD17B1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD17B1
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		SwitchGear 3'UTR luciferase reporter plasmid: HSD17B1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD17B1 (see all 7) OriGene shRNA RFP: HSD17B1 OriGene siRNA: HSD17B1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD17B1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HSD17B1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD17B1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HSD17B1 (NM_004493)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD17B1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD17B1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HSD17B1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for HSD17B1 gene

	Super-pathway	contained gene-specific pathways
1	Estrone metabolism	Estrone metabolism 1.00 Estrogen biosynthesis 0.47 Estrone metabolism 1.00 Estrogen biosynthesis 0.47 Androstenedione and testosterone biosynthesis and metabolism p.1 0.57 Steroid Biosynthesis 0.21 Androstenedione and testosterone biosynthesis and metabolism p.1 0.57
2	Metabolism	Metabolism 1.00 Metabolism of lipids and lipoproteins 0.34 Metabolic pathways 0.38
3	Estrogen biosynthesis	Estrogen biosynthesis 1.00 Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics 0.40 Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 0.50
4	Vitamin D (calciferol) metabolism	Metabolism of steroid hormones and vitamin D 0.27 Steroid hormones 0.27
5	Valproic Acid Pathway, Pharmacokinetics	Valproic Acid Pathway, Pharmacokinetics 1.00

3 EMD Millipore Pathways for HSD17B1

	Androstenedione and testosterone biosynthesis and metabolism p.1
	Estrone metabolism
	Estrogen biosynthesis

3 GeneGo (Thomson Reuters) Pathways for HSD17B1

	Estrogen biosynthesis
	Estrone metabolism
	Androstenedione and testosterone biosynthesis and metabolism p.1

2 BioSystems Pathways for HSD17B1

	Steroid Biosynthesis
	estrogen biosynthesis

5        Reactome Pathways for HSD17B1

	Metabolism of steroid hormones and vitamin D
	Metabolism
	Steroid hormones
	Estrogen biosynthesis
	Metabolism of lipids and lipoproteins

4 PharmGKB Pathways for HSD17B1

	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics
	Aromatase Inhibitor Pathway (Multiple Tissues), Pharmacodynamics
	Estrogen Metabolism Pathway
	Valproic Acid Pathway, Pharmacokinetics

2         Kegg Pathways  (Kegg details for HSD17B1)

	Steroid hormone biosynthesis
	Metabolic pathways

HSD17B1 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HSD17B1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/26 Interacting proteins for HSD17B1 (ENSP00000225929⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for HSD17B1 gene

Transcripts
for HSD17B1 gene

Expression
for HSD17B1 gene

HSD17B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACCGGGAAG

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	OvaryPrimary FollicleGranulosa Cells			Ovary
	BoneMaxillary Process			Bone
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)			Bone, Cartilage, Limb
	Syncytiotrophoblast-like cells (Generation of syncyt...)
	Mature follicles (In-vitro growth and ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD17B1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSD17B1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD17B1
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD17B1

Orthologs
for HSD17B1 gene

Paralogs
for HSD17B1 gene

Paralogs for HSD17B1 gene

SDR9C7²  DHRS9²  HSD11B2²  HSD17B6²  HSD17B2²  BDH1²  RDH8²  RDH16²  

DHRS7B²  DHRS7²  KDSR²  DHRS7C²  RDH5²  

3 SIMAP similar genes for HSD17B1 using alignment to 2 protein entries:     DHB1_HUMAN (see all proteins):

17BHSDI    RDH8    BDH1

HSD17B1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for HSD17B1
PGOHUM00000259231

Genomic Variants
for HSD17B1 gene

10/131 NCBI SNPs in HSD17B1 are shown (see all 131)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1171319901,2	F,	--	40701990(+)	GGCAGA/GAGTCA	1	--	us2k1		1		NA	120
rs1894738391,2		--	40702240(+)	AAACAA/GACAGG	1	--	us2k1		0	--	--	--	--
rs620758361,2	C	--	40702252(+)	GCCTGC/TTGGAG	1	--	us2k1		1		NA	2
rs620758371,2	F,	--	40702283(+)	GCACTA/GGGGGA	1	--	us2k1		1		NA	120
rs556717471,2	C,	--	40702416(+)	TCGCCC/TTGCCC	1	--	us2k1		0	--	--	--	--
rs1172768961,2	F,	--	40702419(+)	CCTTGC/ACCTGC	1	--	us2k1		1		NA	120
rs1930914441,2		--	40702433(+)	CCCAGA/GCAGAT	1	--	us2k1		0	--	--	--	--
rs1844823311,2		--	40702760(+)	CCCCCC/TACCAA	1	--	us2k1		0	--	--	--	--
rs99158241,2	C,A	--	40702841(+)	CTGATG/ACAATG	1	--	us2k1		1		NA	2
rs1397621131,2		--	40702893(+)	CCTACC/TGGCTC	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HSD17B1 (40701232 - 40707232 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HSD17B1
     2 CNVs: 5861 23316
Human Gene Mutation Database (HGMD): HSD17B1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSD17B1

DNA2.0 Custom Variant and Variant Library Synthesis for HSD17B1

Disorders / Diseases
for HSD17B1 gene

20/34 diseases for HSD17B1

6 Novoseek disease relationships for HSD17B1 gene    About this table

Publications
for HSD17B1 gene

PubMed articles for HSD17B1 gene, integrated from 9 sources (see all 148): (articles sorted by number of sources associating them with HSD17B1)

Utopia: connect your pdf to the dynamic world of online information

1. Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes. (PubMed id 2330005)^{1, 2, 3} Luu-The V.... Labrie F. (1990)
2. HSD17B1 gene polymorphisms and risk of endometrial and breast cancer. (PubMed id 14973105)^{1, 4, 9} Setiawan V.W....De Vivo I. (2004)
3. Genetic variation in the HSD17B1 gene and risk of prostate cancer. (PubMed id 16311626)^{1, 4, 9} Kraft P....Wacholder S. (2005)
4. HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore. (PubMed id 12584742)^{1, 4, 9} Wu A.H....Yu M.C. (2003)
5. Association between endometriosis and genetic polymorphisms of the estradiol-synthesizing enzyme genes HSD17B1 and CYP19. (PubMed id 15640252)^{1, 4, 9} Tsuchiya M....Ikenoue T. (2005)
6. Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions. (PubMed id 16260521)^{1, 4, 9} Huber A....Tempfer C.B. (2005)
7. The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)^{1, 3} Persson B.... Oppermann U. (2009)
8. Single-nucleotide polymorphisms in the 17beta-hydroxy steroid dehydrogenase genes might predict the risk of side-effects of estramust ine phosphate sodium in prostate cancer patients. (PubMed id 15733111)^{1, 4} Suzuki M....Kitamura T. (2005)
9. Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women. (PubMed id 15241822)^{1, 4} Hefler L.A....Koelbl H. (2004)
10. Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation. (PubMed id 14966133)^{1, 2} Shi R. and Lin S.X. (2004)

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