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Aliases for HSD11B1L Gene

Aliases for HSD11B1L Gene

  • Hydroxysteroid (11-Beta) Dehydrogenase 1-Like 2 3
  • Short Chain Dehydrogenase/Reductase Family 26C Member 2 3 4
  • 11-Beta-Hydroxysteroid Dehydrogenase Type 3 3 4
  • Short Chain Dehydrogenase/Reductase 10 2 3
  • 11-Beta-HSD3 3 4
  • SDR26C2 3 4
  • 11-DH3 3 4
  • SCDR10 3 4
  • HSD3 3 4
  • Short Chain Dehydrogenase/Reductase Family 26C, Member 2 3
  • Hydroxysteroid 11-Beta-Dehydrogenase 1-Like Protein 3
  • Short Chain Dehydrogenase/Reductase Family 26C 2
  • Short-Chain Dehydrogenase/Reductase 10 4
  • EC 1.1.1.- 4
  • Member 2 2
  • EC 1.1.1 63
  • SCDR10B 3

External Ids for HSD11B1L Gene

Previous GeneCards Identifiers for HSD11B1L Gene

  • GC19P005633
  • GC19P005441

Summaries for HSD11B1L Gene

Entrez Gene Summary for HSD11B1L Gene

  • This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for HSD11B1L Gene

HSD11B1L (Hydroxysteroid (11-Beta) Dehydrogenase 1-Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD11B1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD11B1L Gene

Genomics for HSD11B1L Gene

Regulatory Elements for HSD11B1L Gene

Transcription factor binding sites by QIAGEN in the HSD11B1L gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSD11B1L Gene

Start:
5,680,604 bp from pter
End:
5,688,523 bp from pter
Size:
7,920 bases
Orientation:
Plus strand

Genomic View for HSD11B1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSD11B1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD11B1L Gene

Proteins for HSD11B1L Gene

  • Protein details for HSD11B1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5J1-DHI1L_HUMAN
    Recommended name:
    Hydroxysteroid 11-beta-dehydrogenase 1-like protein
    Protein Accession:
    Q7Z5J1
    Secondary Accessions:
    • Q05D45
    • Q52LF4
    • Q7Z5I9
    • Q7Z5J0
    • Q7Z5P5
    • Q7Z5P6
    • Q7Z5P7
    • Q7Z5P8

    Protein attributes for HSD11B1L Gene

    Size:
    315 amino acids
    Molecular mass:
    34288 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSD11B1L Gene

neXtProt entry for HSD11B1L Gene

Proteomics data for HSD11B1L Gene at MOPED

Selected DME Specific Peptides for HSD11B1L Gene

Post-translational modifications for HSD11B1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for HSD11B1L Gene

Gene Families for HSD11B1L Gene

HGNC:
  • SDRC3 :Short chain dehydrogenase/reductase superfamily / Classical SDR fold cluster 3

Protein Domains for HSD11B1L Gene

Suggested Antigen Peptide Sequences for HSD11B1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5J1

UniProtKB/Swiss-Prot:

DHI1L_HUMAN :
  • Q7Z5J1
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD11B1L: view

Function for HSD11B1L Gene

Enzyme Numbers (IUBMB) for HSD11B1L Gene

Gene Ontology (GO) - Molecular Function for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSD11B1L: view

Phenotypes for HSD11B1L Gene

genes like me logo Genes that share phenotypes with HSD11B1L: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSD11B1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HSD11B1L Gene

Localization for HSD11B1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD11B1L Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HSD11B1L Gene COMPARTMENTS Subcellular localization image for HSD11B1L gene
Compartment Confidence
extracellular 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HSD11B1L: view

Pathways for HSD11B1L Gene

SuperPathways for HSD11B1L Gene

No Data Available

Interacting Proteins for HSD11B1L Gene

Gene Ontology (GO) - Biological Process for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD11B1L: view

No data available for Pathways by source for HSD11B1L Gene

Transcripts for HSD11B1L Gene

Unigene Clusters for HSD11B1L Gene

Hydroxysteroid (11-beta) dehydrogenase 1-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSD11B1L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSD11B1L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - -
SP14: - - -
SP15: -
SP16: - - - - - - - - -
SP17: - - -
SP18: - - - - -
SP19:

Relevant External Links for HSD11B1L Gene

GeneLoc Exon Structure for
HSD11B1L
ECgene alternative splicing isoforms for
HSD11B1L

Expression for HSD11B1L Gene

mRNA expression in normal human tissues for HSD11B1L Gene

mRNA differential expression in normal tissues according to GTEx for HSD11B1L Gene

This gene is overexpressed in Brain - Amygdala (5.1), Brain - Cortex (4.9), Brain - Anterior cingulate cortex (BA24) (4.6), Brain - Frontal Cortex (BA9) (4.2), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HSD11B1L Gene

SOURCE GeneReport for Unigene cluster for HSD11B1L Gene Hs.631840

genes like me logo Genes that share expressions with HSD11B1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for HSD11B1L Gene

Orthologs for HSD11B1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD11B1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HSD11B1L 35
  • 85.55 (n)
  • 88.81 (a)
HSD11B1L 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSD11B1L 35
  • 90.31 (n)
  • 91.13 (a)
HSD11B1L 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HSD11B1L 35
  • 93.31 (n)
  • 92.61 (a)
HSD11B1L 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSD11B1L 35
  • 64.3 (n)
  • 58.66 (a)
HSD11B1L 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSD11B1L 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd11b1l 35
  • 52.72 (n)
  • 52.85 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
hsd11b1la 35
  • 55.82 (n)
  • 53.17 (a)
HSD11B1L (1 of 2) 36
  • 40 (a)
OneToMany
hsd11b1la 36
  • 42 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons HSD1 35
  • 45.32 (n)
  • 37.08 (a)
rice
(Oryza sativa)
Liliopsida Os12g0464400 35
  • 47.46 (n)
  • 44.02 (a)
Species with no ortholog for HSD11B1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSD11B1L Gene

ENSEMBL:
Gene Tree for HSD11B1L (if available)
TreeFam:
Gene Tree for HSD11B1L (if available)

Paralogs for HSD11B1L Gene

Paralogs for HSD11B1L Gene

Selected SIMAP similar genes for HSD11B1L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with HSD11B1L: view

Variants for HSD11B1L Gene

Sequence variations from dbSNP and Humsavar for HSD11B1L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2275243 -- 5,686,317(-) AAACC(A/C/G)CCCCC intron-variant
rs3097895 -- 5,682,904(+) tctcc(A/G)ccccg intron-variant
rs3215972 -- 5,686,312(-) CCCCC(-/C)TACTC intron-variant
rs3760768 -- 5,688,177(-) AACAG(A/G)TGAGG utr-variant-3-prime, reference, synonymous-codon
rs8102068 -- 5,683,502(+) cctga(A/G)gaccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD11B1L Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910894 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294
dgv3695n71 CNV Loss 21882294

Relevant External Links for HSD11B1L Gene

HapMap Linkage Disequilibrium report
HSD11B1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD11B1L Gene

Disorders for HSD11B1L Gene

No disorders were found for HSD11B1L Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HSD11B1L Gene

Publications for HSD11B1L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics. (PMID: 15342248) Kissinger C.R. … Villafranca J.E. (J. Mol. Biol. 2004) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase. (PMID: 19436836) Huang C. … Yu L. (Acta Biochim. Pol. 2009) 3
  5. Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3. (PMID: 20350543) Baker M.E. (FEBS Lett. 2010) 3

Products for HSD11B1L Gene

Sources for HSD11B1L Gene

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