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Aliases for HSD11B1L Gene

Aliases for HSD11B1L Gene

  • Hydroxysteroid 11-Beta Dehydrogenase 1 Like 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 26C Member 2 3 4
  • 11-Beta-Hydroxysteroid Dehydrogenase Type 3 3 4
  • Short Chain Dehydrogenase/Reductase 10 2 3
  • 11-Beta-HSD3 3 4
  • SDR26C2 3 4
  • 11-DH3 3 4
  • SCDR10 3 4
  • HSD3 3 4
  • Short Chain Dehydrogenase/Reductase Family 26C, Member 2 2
  • Hydroxysteroid 11-Beta-Dehydrogenase 1-Like Protein 3
  • Hydroxysteroid (11-Beta) Dehydrogenase 1-Like 2
  • Short-Chain Dehydrogenase/Reductase 10 4
  • EC 1.1.1.- 4
  • EC 1.1.1 58
  • SCDR10B 3

External Ids for HSD11B1L Gene

Previous GeneCards Identifiers for HSD11B1L Gene

  • GC19P005633
  • GC19P005441

Summaries for HSD11B1L Gene

Entrez Gene Summary for HSD11B1L Gene

  • This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for HSD11B1L Gene

HSD11B1L (Hydroxysteroid 11-Beta Dehydrogenase 1 Like) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is HSD11B1.

Additional gene information for HSD11B1L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD11B1L Gene

Genomics for HSD11B1L Gene

Regulatory Elements for HSD11B1L Gene

Enhancers for HSD11B1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H005620 1.7 FANTOM5 ENCODE dbSUPER 11.8 -57.2 -57216 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 RPL36 C19orf70 HSD11B1L LONP1 SAFB2 SAFB DUS3L VMAC RFX2
GH19H005626 1.5 Ensembl ENCODE dbSUPER 11.5 -52.2 -52229 3 HDGF PKNOX1 ATF1 ZNF766 ELK1 ATF7 CAVIN1 ZNF592 MEF2D MYNN RPL36 SNRPEP4 KHSRP C19orf70 HSD11B1L ENSG00000267571 DUS3L SAFB2
GH19H006527 1.4 ENCODE dbSUPER 9.7 +850.0 850040 6 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 ZNF766 ZNF143 ZNF207 ZNF557 KHSRP DUS3L SAFB SAFB2 SNRPEP4 ENSG00000267571 GTF2F1 RANBP3 VMAC
GH19H005679 1.1 ENCODE 10.4 -0.2 -165 2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 DUS3L SAFB KHSRP ENSG00000267571 KDM4B RANBP3 SAFB2 GTF2F1 RPL36 ACSBG2
GH19H005351 0.8 ENCODE 9.7 -328.4 -328390 1 BCOR GTF2F1 TBP DRAP1 PKNOX1 ARNT GTF2E2 NFRKB ZNF76 KLF17 SH3GL1 ENSG00000267255 ZNRF4 VMAC RPL36 ENSG00000267571 SAFB2 DUS3L HSD11B1L PTPRS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSD11B1L on UCSC Golden Path with GeneCards custom track

Promoters for HSD11B1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106404 -4 1601 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766

Transcription factor binding sites by QIAGEN in the HSD11B1L gene promoter:

Genomic Location for HSD11B1L Gene

Chromosome:
19
Start:
5,680,604 bp from pter
End:
5,688,523 bp from pter
Size:
7,920 bases
Orientation:
Plus strand

Genomic View for HSD11B1L Gene

Genes around HSD11B1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD11B1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD11B1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD11B1L Gene

Proteins for HSD11B1L Gene

  • Protein details for HSD11B1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5J1-DHI1L_HUMAN
    Recommended name:
    Hydroxysteroid 11-beta-dehydrogenase 1-like protein
    Protein Accession:
    Q7Z5J1
    Secondary Accessions:
    • Q05D45
    • Q52LF4
    • Q7Z5I9
    • Q7Z5J0
    • Q7Z5P5
    • Q7Z5P6
    • Q7Z5P7
    • Q7Z5P8

    Protein attributes for HSD11B1L Gene

    Size:
    315 amino acids
    Molecular mass:
    34288 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HSD11B1L Gene

neXtProt entry for HSD11B1L Gene

Selected DME Specific Peptides for HSD11B1L Gene

Q7Z5J1:
  • GARVLLTG
  • LAYHYARLG

Post-translational modifications for HSD11B1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for HSD11B1L

Domains & Families for HSD11B1L Gene

Gene Families for HSD11B1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for HSD11B1L Gene

Suggested Antigen Peptide Sequences for HSD11B1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z5J1

UniProtKB/Swiss-Prot:

DHI1L_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD11B1L: view

Function for HSD11B1L Gene

Enzyme Numbers (IUBMB) for HSD11B1L Gene

Phenotypes From GWAS Catalog for HSD11B1L Gene

Gene Ontology (GO) - Molecular Function for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with HSD11B1L: view
genes like me logo Genes that share phenotypes with HSD11B1L: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for HSD11B1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSD11B1L Gene

Localization for HSD11B1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD11B1L Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD11B1L gene
Compartment Confidence
nucleus 5
extracellular 4
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with HSD11B1L: view

Pathways & Interactions for HSD11B1L Gene

SuperPathways for HSD11B1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for HSD11B1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD11B1L: view

No data available for Pathways by source and SIGNOR curated interactions for HSD11B1L Gene

Drugs & Compounds for HSD11B1L Gene

No Compound Related Data Available

Transcripts for HSD11B1L Gene

Unigene Clusters for HSD11B1L Gene

Hydroxysteroid (11-beta) dehydrogenase 1-like:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for HSD11B1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HSD11B1L Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: - - - - - - - -
SP14: - - -
SP15: -
SP16: - - - - - - - - -
SP17: - - -
SP18: - - - - -
SP19:

Relevant External Links for HSD11B1L Gene

GeneLoc Exon Structure for
HSD11B1L
ECgene alternative splicing isoforms for
HSD11B1L

Expression for HSD11B1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSD11B1L Gene

mRNA differential expression in normal tissues according to GTEx for HSD11B1L Gene

This gene is overexpressed in Brain - Amygdala (x5.1), Brain - Cortex (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Frontal Cortex (BA9) (x4.2), and Brain - Hippocampus (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSD11B1L Gene



NURSA nuclear receptor signaling pathways regulating expression of HSD11B1L Gene:

HSD11B1L

SOURCE GeneReport for Unigene cluster for HSD11B1L Gene:

Hs.631840

Evidence on tissue expression from TISSUES for HSD11B1L Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with HSD11B1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HSD11B1L Gene

Orthologs for HSD11B1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSD11B1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSD11B1L 33 34
  • 93.31 (n)
dog
(Canis familiaris)
Mammalia HSD11B1L 33 34
  • 90.31 (n)
cow
(Bos Taurus)
Mammalia HSD11B1L 33 34
  • 85.55 (n)
chicken
(Gallus gallus)
Aves HSD11B1L 33 34
  • 64.3 (n)
lizard
(Anolis carolinensis)
Reptilia HSD11B1L 34
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd11b1l 33
  • 52.72 (n)
zebrafish
(Danio rerio)
Actinopterygii hsd11b1la 33 34
  • 55.82 (n)
HSD11B1L (1 of 2) 34
  • 40 (a)
OneToMany
-- 33
thale cress
(Arabidopsis thaliana)
eudicotyledons HSD1 33
  • 45.32 (n)
rice
(Oryza sativa)
Liliopsida Os12g0464400 33
  • 47.46 (n)
Species where no ortholog for HSD11B1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HSD11B1L Gene

ENSEMBL:
Gene Tree for HSD11B1L (if available)
TreeFam:
Gene Tree for HSD11B1L (if available)

Paralogs for HSD11B1L Gene

Paralogs for HSD11B1L Gene

(1) SIMAP similar genes for HSD11B1L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with HSD11B1L: view

Variants for HSD11B1L Gene

Sequence variations from dbSNP and Humsavar for HSD11B1L Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000284436 -- 5,682,605(+) GGTAT(A/G)GGGTG intron-variant, upstream-variant-2KB
rs1000335820 -- 5,687,964(+) CCCCT(A/C)CAGTC reference, synonymous-codon, missense, utr-variant-3-prime
rs1000668176 -- 5,686,698(+) GAGCT(A/C)TGAAC intron-variant
rs1000919098 -- 5,682,248(+) CACAG(A/G)CGCCT intron-variant, upstream-variant-2KB
rs1001067229 -- 5,687,819(+) GGCGC(C/T)ACGCG intron-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for HSD11B1L Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv953952 CNV deletion 24416366

Variation tolerance for HSD11B1L Gene

Gene Damage Index Score: 1.82; 34.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSD11B1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSD11B1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD11B1L Gene

Disorders for HSD11B1L Gene

Relevant External Links for HSD11B1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSD11B1L

No disorders were found for HSD11B1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSD11B1L Gene

Publications for HSD11B1L Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3. (PMID: 20350543) Baker ME (FEBS letters 2010) 3 60
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 60
  4. Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase. (PMID: 19436836) Huang C … Yu L (Acta biochimica Polonica 2009) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for HSD11B1L Gene

Sources for HSD11B1L Gene

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