Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HSD11B1L Gene

protein-coding   GIFtS: 41
GCID: GC19P005680

hydroxysteroid (11-beta) dehydrogenase 1-like

 Explore 3 diseases affiliated with
HSD11B1L via our new
 Human Malady Compendium 
Biological research products
for HSD11B1L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Hydroxysteroid (11-Beta) Dehydrogenase 1-Like1 2     SCDR10B2
SCDR101 2 3     Hydroxysteroid 11-Beta-Dehydrogenase 1-Like Protein2
SDR26C21 2     Short Chain Dehydrogenase/Reductase 102
11-DH32 3     Short Chain Dehydrogenase/Reductase Family 26C, Member 22
11-Beta-HSD31     EC 1.1.1.-3
11-Beta-Hydroxysteroid Dehydrogenase Type 32 3     Short-Chain Dehydrogenase/Reductase 103
HSD32 3     EC 1.1.18

External Ids:    HGNC: 304191   Entrez Gene: 3748752   Ensembl: ENSG000001677337   UniProtKB: Q7Z5J13   

Export aliases for HSD11B1L gene to outside databases

Previous GC identifers: GC19P005633 GC19P005441


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HSD11B1L:
This gene is a member of the hydroxysteroid dehydrogenase family. The encoded protein is similar to an enzyme that
catalyzes the interconversion of inactive to active glucocorticoids (e.g. cortisone). Alternatively spliced transcript
variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jun 2012)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HSD11B1L gene promoter:
         USF1   p300   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHSD11B1L promoter sequence
   Search SABiosciences Chromatin IP Primers for HSD11B1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD11B1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

HSD11B1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSD11B1L gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P005680:  view genomic region     (about GC identifiers)

Start:
5,680,615 bp from pter      End:
5,688,533 bp from pter
Size:
7,919 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DHI1L_HUMAN, Q7Z5J1 (See protein sequence)
Recommended Name: Hydroxysteroid 11-beta-dehydrogenase 1-like protein precursor  
Size: 315 amino acids; 34288 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q05D45 Q52LF4 Q7Z5I9 Q7Z5J0 Q7Z5P5 Q7Z5P6 Q7Z5P7 Q7Z5P8
Alternative splicing: 8 isoforms:  Q7Z5J1-1   Q7Z5J1-2   Q7Z5J1-3   Q7Z5J1-4   Q7Z5J1-5   Q7Z5J1-6   Q7Z5J1-7   Q7Z5J1-8   

Explore the universe of human proteins at neXtProt for HSD11B1L: NX_Q7Z5J1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z5J1

  • 2 DME Specific Peptides for HSD11B1L (Q7Z5J1)
     GARVLLTG  LAYHYARLG 

    HSD11B1L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (10 alternative transcripts): 
    NP_001254797.1  NP_001254798.1  NP_001254799.1  NP_001254800.1  NP_940935.1  NP_941993.1  NP_941994.1  NP_941995.1  
    NP_941996.1  NP_941997.1  

    ENSEMBL proteins: 
     ENSP00000464652   ENSP00000463073   ENSP00000464454   ENSP00000463274   ENSP00000398955  
     ENSP00000301382   ENSP00000462975   ENSP00000407154   ENSP00000462058   ENSP00000462586  
     ENSP00000462113   ENSP00000343451   ENSP00000409592   ENSP00000463794   ENSP00000340436  
     ENSP00000464563   ENSP00000463187   ENSP00000462921  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): HSD11B1L
    OriGene Custom Protein Services for HSD11B1L 
    GenScript Custom Purified and Recombinant Proteins Services for HSD11B1L
    Novus Biologicals HSD11B1L Protein
    Novus Biologicals HSD11B1L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    HSD11B1L for ontologies           About GeneDecksing



    HSD11B1L Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HSD11B1L 
    GenScript Custom Superior Antibodies Services for HSD11B1L
    Search for Antibodies for HSD11B1L at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for HSD11B1L

    Assay Products for HSD11B1L: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HSD11B1L
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HSD11B1L for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020904 Sc_DH/Rdtase_CS
     IPR002347 Glc/ribitol_DH
     IPR002198 DH_sc/Rdtase_SDR
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q7Z5J1

    ProtoNet protein and cluster: Q7Z5J1

    1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR

    UniProtKB/Swiss-Prot: DHI1L_HUMAN, Q7Z5J1
    Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Enzyme Numbers (IUBMB): EC 1.1.12 EC 1.1.1.-1

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 6): HSD11B1L
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD11B1L
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HSD11B1L:
    hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidHSD11B1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD11B1L
    OriGene shRNA RFP: HSD11B1L
    OriGene siRNA: HSD11B1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD11B1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HSD11B1L

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): HSD11B1L (NM_198706)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD11B1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD11B1L 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HSD11B1L
    Search LifeMap BioReagents cell lines for HSD11B1L

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD11B1L

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0016491oxidoreductase activity IEA--


    HSD11B1L for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HSD11B1L:
     Decreased viability of wild-ty 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSD11B1L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HSD11B1L
    Search CenterWatch for drugs/clinical trials and news about HSD11B1L / DHI1L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HSD11B1L gene (10 alternative transcripts): 
    NM_001267868.1  NM_001267869.1  NM_001267870.1  NM_001267871.1  NM_198533.2  NM_198704.2  NM_198705.2  NM_198706.2  
    NM_198707.2  NM_198708.2  

    Unigene Clusters for HSD11B1L:

    Hydroxysteroid (11-beta) dehydrogenase 1-like
    Hs.631840  [show with all ESTs], Hs.739286  [show with all ESTs]
    Unigene Representative Sequences: NM_001267868, BM807358
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000577257 ENST00000577917(uc002mcl.3) ENST00000581893(uc002mcu.3)
    ENST00000582346 ENST00000411793(uc002mcq.3) ENST00000301382(uc002mcr.3)
    ENST00000581773 ENST00000423665(uc002mck.3) ENST00000584904 ENST00000583928
    ENST00000579562(uc002mcp.3) ENST00000342970(uc002mco.3) ENST00000422535(uc002mcj.3)
    ENST00000578167(uc002mct.3) ENST00000577701 ENST00000581521(uc010dug.3)
    ENST00000339423(uc002mcn.3) ENST00000578832

    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 6): HSD11B1L
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HSD11B1L
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HSD11B1L:
    hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidHSD11B1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD11B1L
    OriGene shRNA RFP: HSD11B1L
    OriGene siRNA: HSD11B1L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD11B1L
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L (see all 6)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): HSD11B1L (NM_198706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HSD11B1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD11B1L 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD11B1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HSD11B1L
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD11B1L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD11B1L

    Additional cDNA sequence: 

    BC018336.1 BC062777.1 

    24/37 DOTS entries (see all 37):

    DT.100801923  DT.121494836  DT.87017359  DT.99948831  DT.92450758  DT.92450757  DT.446569  DT.100795852 
    DT.305319  DT.101962926  DT.121494754  DT.100890867  DT.101962898  DT.121494687  DT.121494705  DT.100022648 
    DT.100767003  DT.121494806  DT.92036786  DT.100801918  DT.100890826  DT.121104866  DT.92450764  DT.100769294 

    24/786 AceView cDNA sequences (see all 786):

    BQ950113 BU538486 AJ713612 BU174273 AI815607 AV763969 AI735002 BU849726 
    BP430077 BU189190 AI761851 F20887 BU156941 BG752946 AA328203 BG337381 
    AY313895 BU956561 BU162409 F22482 CB105662 AJ572588 BG491231 BM740105 

    GeneLoc Exon Structure

    5/19 Alternative Splicing Database (ASD) splice patterns (SP) for HSD11B1L (see all 19)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c
    SP1:                                            -     -                 -                 -                                               -                     
    SP2:                                            -     -                 -                 -                                                                     
    SP3:                                            -     -     -     -                       -                                                                     
    SP4:                                            -     -                 -                 -     -                                                               
    SP5:                                            -     -     -     -                       -     -                                                               


    ECgene alternative splicing isoforms for HSD11B1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HSD11B1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HSD11B1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HSD11B1L

    SOURCE GeneReport for Unigene clusters: Hs.631840 Hs.739286
        SABiosciences Custom PCR Arrays for HSD11B1L
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD11B1L
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HSD11B1L
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD11B1L
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD11B1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD11B1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSD11B1L gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HSD11B1L1 hydroxysteroid (11-beta) dehydrogenase 1-like 63.09(n)
    57.04(a)
      408034  NM_001001201.1  NP_001001201.1 
    lizard
    (Anolis carolinensis)
    Reptilia HSD11B1L6
    --
    58(a)
    1 ↔ 1
    GL343717.1(95093-100045)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC061652.12   -- 71.09(n)    BC061652.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC052103.12   -- 75.74(n)   393293  BC052103.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HSD11 hydroxysteroid dehydrogenase 1 45.32(n)
    37.08(a)
      835129  NM_124448.4  NP_568742.1 
    rice
    (Oryza sativa)
    Liliopsida Os12g04644001 hypothetical protein 47.46(n)
    44.02(a)
      4352184  NM_001073272.1  NP_001066740.1 
            Species with no ortholog for HSD11B1L

    ENSEMBL Gene Tree for HSD11B1L (if available)
    TreeFam Gene Tree for HSD11B1L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HSD11B1L gene
    HSD11B12  
    1 SIMAP similar gene for HSD11B1L using alignment to 7 protein entries:     DHI1L_HUMAN (see all proteins):
    HSD11B1

    HSD11B1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/67 NCBI SNPs in HSD11B1L are shown (see all 67    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30978951,2
    C,F,--5682915(+) TCTCCA/GCCCCG 10 -- int111Minor allele frequency- G:0.47NA WA CSA EA 373
    rs746881141,2
    C,--5682919(+) CACCCC/TGCTGG 10 -- int12Minor allele frequency- T:0.09WA 120
    rs1888765101,2
    --5683092(+) ACTGGA/GTTTCT 10 -- int10--------
    rs1416807011,2
    C,--5683255(+) CTGTT-/TCTCTCT 10 -- int10--------
    rs1389947621,2
    --5683284(+) ATTAGC/TGAATC 10 -- int10--------
    rs1428987351,2
    --5683304(+) AGCTGA/CAATCA 10 -- int10--------
    rs1924867901,2
    --5683399(+) AGAGCA/GAGCTG 10 -- int10--------
    rs1445874861,2
    --5683436(+) CCCACA/GTGCCT 10 -- int10--------
    rs1844811531,2
    --5683472(+) ACCTAC/TTGAGC 10 -- int10--------
    rs1873162071,2
    --5683503(+) AGTTTG/TGGGCC 10 -- int10--------

    HapMap Linkage Disequilibrium report for HSD11B1L (5680615 - 5688533 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HSD11B1L: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSD11B1L
    DNA2.0 Custom Variant and Variant Library Synthesis for HSD11B1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HSD11B1L for disorders           About GeneDecksing

    3 diseases for HSD11B1L:    About MalaCards
    alzheimer's disease    tuberculosis    mycobacterium tuberculosis


    Export disorders for HSD11B1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HSD11B1L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HSD11B1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3. (PubMed id 20350543)1 Baker M.E. (2010)
    3. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    4. Isolation and characterization of novel human short-c hain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenase. (PubMed id 19436836)1 Huang C....Yu L. (2009)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics. (PubMed id 15342248)1 Kissinger C.R....Villafranca J.E. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 374875 HGNC: 30419 AceView: RPL36andSCDR10 Ensembl:ENSG00000167733 euGenes: HUgn374875
    ECgene: HSD11B1L H-InvDB: HSD11B1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HSD11B1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HSD11B1L gene:
    Search GeneIP for patents involving HSD11B1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HSD11B1L  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSD11B1L   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSD11B1L  
     OriGene Protein Over-expression Lysate for HSD11B1L   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HSD11B1L   OriGene 3'-UTR Clone for HSD11B1L  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSD11B1L  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HSD11B1L   OriGene Custom Protein Services for HSD11B1L  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSD11B1L
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSD11B1L
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSD11B1L
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSD11B1L
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSD11B1L
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSD11B1L
     GenScript Custom Purified and Recombinant Proteins Services for HSD11B1L GenScript cDNA clones with any tag delivered in your preferred vector for HSD11B1L
     GenScript Custom Assay Services for HSD11B1L GenScript Custom Superior Antibodies Services for HSD11B1L
     GenScript Custom overexpressing Cell Line Services for HSD11B1L CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HSD11B1L promoter
     Search Chromatin IP Primers for HSD11B1L
     RT2 qPCR Primer Assay in human, mouse / rat HSD11B1L
     Search GNC Networks for HSD11B1L
     SABiosciences Custom PCR Arrays for HSD11B1L
     Search Tocris compounds for HSD11B1L
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HSD11B1L proteins
     HSD11B1L lysates
     Search for Antibodies for HSD11B1L at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HSD11B1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for HSD11B1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSD11B1L
     SwitchGear 3'UTR luciferase reporter plasmids for HSD11B1L
     SwitchGear Promoter luciferase reporter plasmids for HSD11B1L
     Search ThermoFisher Antibodies for HSD11B1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSD11B1L
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HSD11B1L gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4