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Aliases for HSD11B1 Gene

Aliases for HSD11B1 Gene

  • Hydroxysteroid 11-Beta Dehydrogenase 1 2 3 5
  • Short Chain Dehydrogenase/Reductase Family 26C Member 1 3 4
  • 11-Beta-HSD1 3 4
  • EC 1.1.1.146 4 58
  • SDR26C1 3 4
  • HSD11L 3 4
  • HSD11 3 4
  • 11-DH 3 4
  • Short Chain Dehydrogenase/Reductase Family 26C, Member 1 2
  • Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 3
  • Hydroxysteroid (11-Beta) Dehydrogenase 1 2
  • 11-Beta-Hydroxysteroid Dehydrogenase 1 4
  • EC 1.1.1 58
  • CORTRD2 3
  • HSD11B 3
  • HDL 3

External Ids for HSD11B1 Gene

Previous HGNC Symbols for HSD11B1 Gene

  • HSD11B
  • HSD11

Previous GeneCards Identifiers for HSD11B1 Gene

  • GC01P208517
  • GC01P205584
  • GC01P206517
  • GC01P206938
  • GC01P206247
  • GC01P207926
  • GC01P209859
  • GC01P180534

Summaries for HSD11B1 Gene

Entrez Gene Summary for HSD11B1 Gene

  • The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

GeneCards Summary for HSD11B1 Gene

HSD11B1 (Hydroxysteroid 11-Beta Dehydrogenase 1) is a Protein Coding gene. Diseases associated with HSD11B1 include Cortisone Reductase Deficiency 2 and Hyperandrogenism Due To Cortisone Reductase Deficiency. Among its related pathways are Metabolism and Prostaglandin Synthesis and Regulation. GO annotations related to this gene include oxidoreductase activity and 11-beta-hydroxysteroid dehydrogenase (NADP+) activity. An important paralog of this gene is HSD11B1L.

UniProtKB/Swiss-Prot for HSD11B1 Gene

  • Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

Tocris Summary for HSD11B1 Gene

  • 11beta-Hydroxysteroid Dehydrogenases (11beta-HSD) isozymes 11beta-HSD1 and 11beta-HSD2 catalyze the interconversion of cortisol and cortisone. 11beta-HSD1 converts cortisone to cortisol, the active hormone; and 11beta-HSD2 converts cortisol to cortisone, the inactive form.

Gene Wiki entry for HSD11B1 Gene

Additional gene information for HSD11B1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSD11B1 Gene

Genomics for HSD11B1 Gene

Regulatory Elements for HSD11B1 Gene

Enhancers for HSD11B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H209644 2 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -33.2 -33184 16 HDGF FOXA2 PKNOX1 FEZF1 YY1 ZNF766 FOS SP3 JUNB REST G0S2 LAMB3 HSD11B1 LOC101930114 CAMK1G ENSG00000224260 MIR205 MIR205HG IRF6 TRAF3IP3
GH01H209641 1.3 Ensembl ENCODE dbSUPER 11.1 -43.3 -43348 3 BCOR CTCF MAX ZMYM3 ZBTB40 RAD21 YY1 FOSL1 ZNF316 POLR2A G0S2 LAMB3 HSD11B1 LOC101930114 CAMK1G ENSG00000224260 MIR4260
GH01H209627 1.3 Ensembl ENCODE dbSUPER 11 -58.5 -58458 1 RB1 KLF17 BATF ZNF2 RAD21 GLIS2 CBX5 ZNF143 FOS CREM ENSG00000224260 G0S2 LOC101930114 HSD11B1 LAMB3 MIR4260
GH01H209607 1.2 Ensembl ENCODE dbSUPER 10.8 -78.2 -78206 1 HDGF BACH1 JUNB EBF1 DPF2 BATF RELA FOSL1 JUND TARDBP ENSG00000224260 CAMK1G HSD11B1 G0S2 LOC101930114 MIR4260
GH01H209587 1 ENCODE dbSUPER 10.3 -98.2 -98228 0 TBP MXI1 JUN RFX5 CTBP1 GATA3 FOSL2 FOS SMARCE1 DPF2 HSD11B1 CAMK1G MIR4260
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HSD11B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HSD11B1 Gene

Chromosome:
1
Start:
209,686,178 bp from pter
End:
209,734,950 bp from pter
Size:
48,773 bases
Orientation:
Plus strand

Genomic View for HSD11B1 Gene

Genes around HSD11B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSD11B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSD11B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSD11B1 Gene

Proteins for HSD11B1 Gene

  • Protein details for HSD11B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28845-DHI1_HUMAN
    Recommended name:
    Corticosteroid 11-beta-dehydrogenase isozyme 1
    Protein Accession:
    P28845
    Secondary Accessions:
    • B2R9Z1
    • D3DT89

    Protein attributes for HSD11B1 Gene

    Size:
    292 amino acids
    Molecular mass:
    32401 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for HSD11B1 Gene

neXtProt entry for HSD11B1 Gene

Selected DME Specific Peptides for HSD11B1 Gene

P28845:
  • NVSITLC
  • IVTGASKG
  • MGAHVVVTARS
  • MEDMTFAE

Post-translational modifications for HSD11B1 Gene

Other Protein References for HSD11B1 Gene

Antibody Products

  • R&D Systems Antibodies for HSD11B1 (11 beta-HSD1)
  • Abcam antibodies for HSD11B1

Domains & Families for HSD11B1 Gene

Gene Families for HSD11B1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for HSD11B1 Gene

Suggested Antigen Peptide Sequences for HSD11B1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P28845

UniProtKB/Swiss-Prot:

DHI1_HUMAN :
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Family:
  • Belongs to the short-chain dehydrogenases/reductases (SDR) family.
genes like me logo Genes that share domains with HSD11B1: view

Function for HSD11B1 Gene

Molecular function for HSD11B1 Gene

GENATLAS Biochemistry:
hydroxysteroid dehydrogenase 11-beta 1,NADP dependent,expressed in liver,lung,testis,catalyzing the interconversion of cortisol and cortisone,glucocorticoid metabolism liver
UniProtKB/Swiss-Prot CatalyticActivity:
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

Enzyme Numbers (IUBMB) for HSD11B1 Gene

Phenotypes From GWAS Catalog for HSD11B1 Gene

Gene Ontology (GO) - Molecular Function for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity TAS --
GO:0016491 oxidoreductase activity IEA --
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA --
genes like me logo Genes that share ontologies with HSD11B1: view
genes like me logo Genes that share phenotypes with HSD11B1: view

Human Phenotype Ontology for HSD11B1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HSD11B1 Gene

MGI Knock Outs for HSD11B1:

Animal Model Products

  • Taconic Biosciences Mouse Models for HSD11B1

CRISPR Products

miRNA for HSD11B1 Gene

miRTarBase miRNAs that target HSD11B1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSD11B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Transcription Factor Targets and HOMER Transcription for HSD11B1 Gene

Localization for HSD11B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSD11B1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HSD11B1 gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 3
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HSD11B1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HSD11B1 Gene

Pathways & Interactions for HSD11B1 Gene

genes like me logo Genes that share pathways with HSD11B1: view

Gene Ontology (GO) - Biological Process for HSD11B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006704 glucocorticoid biosynthetic process TAS --
GO:0008202 steroid metabolic process IEA --
GO:0030324 lung development IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HSD11B1: view

No data available for SIGNOR curated interactions for HSD11B1 Gene

Drugs & Compounds for HSD11B1 Gene

(55) Drugs for HSD11B1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydrocortisone Approved, Vet_approved Pharma Agonist Adrenal glucocorticoid; immunosuppressant 685
Prednisone Approved, Vet_approved Pharma Target, ligand 1436
Tacrolimus Approved, Investigational Pharma 1125
Rayos Approved July of 2012 Pharma 0
Corticosterone Experimental Pharma Target Endogenous glucocorticoid 11

(36) Additional Compounds for HSD11B1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
11-Dehydrocorticosterone
  • 11-Dehydro-Corticosterone
  • 11-Dehydrocorticosteron
  • 11-Dehydrocorticosterone
  • 11-Oxo-11-deoxycorticosterone
  • 11-Oxocorticosterone
72-23-1
7-Ketocholesterol
  • 3b-Hydroxycholest-5-en-7-one
  • 7-Ketocholesterol
  • 7-Oxocholesterol
  • Cholest-5-en-3b-ol-7-one
  • Delta5-Cholesten-3b-ol-7-one
566-28-9
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
11b-Hydroxyandrost-4-ene-3,17-dione
  • 11beta-Hydroxyandrost-4-ene-3,17-dione
  • 4-Androsten-11beta-ol-3,17-dione
  • Androst-4-ene-3,17-dione-11beta-ol
382-44-5
3a,21-Dihydroxy-5b-pregnane-11,20-dione
  • 3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione
  • 5beta-Pregnane-3alpha,21-diol-11,20-dione
566-03-0

(1) Tocris Compounds for HSD11B1 Gene

Compound Action Cas Number
PF 915275 Potent and selective 11beta-hydroxysteroid dehydrogenase inhibitor 857290-04-1

(2) ApexBio Compounds for HSD11B1 Gene

Compound Action Cas Number
Carbenoxolone disodium 7421-40-1
PF 915275 857290-04-1
genes like me logo Genes that share compounds with HSD11B1: view

Drug Products

Transcripts for HSD11B1 Gene

Unigene Clusters for HSD11B1 Gene

Hydroxysteroid (11-beta) dehydrogenase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HSD11B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HSD11B1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1:
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for HSD11B1 Gene

GeneLoc Exon Structure for
HSD11B1
ECgene alternative splicing isoforms for
HSD11B1

Expression for HSD11B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HSD11B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HSD11B1 Gene

This gene is overexpressed in Liver (x23.6).

Protein differential expression in normal tissues from HIPED for HSD11B1 Gene

This gene is overexpressed in Liver (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HSD11B1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HSD11B1 Gene:

HSD11B1

SOURCE GeneReport for Unigene cluster for HSD11B1 Gene:

Hs.195040

mRNA Expression by UniProt/SwissProt for HSD11B1 Gene:

P28845-DHI1_HUMAN
Tissue specificity: Widely expressed. Highest expression in liver.

Evidence on tissue expression from TISSUES for HSD11B1 Gene

  • Liver(4.8)
  • Nervous system(4.5)
  • Adrenal gland(2.7)
  • Kidney(2.4)
  • Blood(2.3)
  • Skin(2.3)
  • Lung(2.2)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HSD11B1 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • reproductive
Organs:
Head and neck:
  • brain
  • face
  • head
  • pituitary gland
Pelvis:
  • ovary
  • testicle
  • uterus
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HSD11B1: view

Primer Products

No data available for Protein tissue co-expression partners for HSD11B1 Gene

Orthologs for HSD11B1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HSD11B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSD11B1 33 34
  • 99.89 (n)
dog
(Canis familiaris)
Mammalia HSD11B1 33 34
  • 86.71 (n)
cow
(Bos Taurus)
Mammalia HSD11B1 33 34
  • 84.54 (n)
rat
(Rattus norvegicus)
Mammalia Hsd11b1 33
  • 79.91 (n)
mouse
(Mus musculus)
Mammalia Hsd11b1 33 16 34
  • 79.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HSD11B1 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC771930 33
  • 63.55 (n)
-- 34
  • 57 (a)
OneToMany
-- 34
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HSD11B1 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hsd11b1 33
  • 59.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC64545 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
-- 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
OneToOne
Species where no ortholog for HSD11B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HSD11B1 Gene

ENSEMBL:
Gene Tree for HSD11B1 (if available)
TreeFam:
Gene Tree for HSD11B1 (if available)

Paralogs for HSD11B1 Gene

Paralogs for HSD11B1 Gene

(1) SIMAP similar genes for HSD11B1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HSD11B1: view

Variants for HSD11B1 Gene

Sequence variations from dbSNP and Humsavar for HSD11B1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035845 A breast cancer sample
rs387907168 Pathogenic 209,707,020(+) ATGTG(C/T)GCAAA intron-variant, reference, missense
rs12086634 Uncertain significance 209,706,914(+) CCAGA(G/T)GATTT intron-variant
rs45487298 Uncertain significance 209,706,873(+) ACCAA(-/A/G)GAGCT intron-variant
rs1000057637 -- 209,716,811(+) GAAAG(A/G)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSD11B1 Gene

Variant ID Type Subtype PubMed ID
nsv1004343 CNV gain 25217958
nsv1006632 CNV gain 25217958
nsv478363 CNV novel sequence insertion 20440878
nsv525445 CNV loss 19592680

Variation tolerance for HSD11B1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HSD11B1 Gene

Human Gene Mutation Database (HGMD)
HSD11B1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HSD11B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSD11B1 Gene

Disorders for HSD11B1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for HSD11B1 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cortisone reductase deficiency 2
  • cortrd2
hyperandrogenism due to cortisone reductase deficiency
  • 11-beta-hydroxysteroid dehydrogenase deficiency type 1
cortisone reductase deficiency
  • cortrd
apparent mineralocorticoid excess
  • 11-beta-hydroxysteroid dehydrogenase deficiency type 2
polycystic ovary syndrome
  • multicystic ovaries
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

DHI1_HUMAN
  • Cortisone reductase deficiency (CRD) [MIM:604931]: In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS). {ECO:0000269 PubMed:12858176}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HSD11B1

Genetic Association Database (GAD)
HSD11B1
Human Genome Epidemiology (HuGE) Navigator
HSD11B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HSD11B1
genes like me logo Genes that share disorders with HSD11B1: view

No data available for Genatlas for HSD11B1 Gene

Publications for HSD11B1 Gene

  1. Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort. (PMID: 19535162) Miyamoto Y … Morisaki T (Diabetes research and clinical practice 2009) 3 22 45 60
  2. Regulatory effect of common promoter polymorphisms on the expression of the 11beta-hydroxysteroid dehydrogenase type 1 gene. (PMID: 19571556) Ku YH … Park KS (Hormone research 2009) 3 22 45 60
  3. [Possible pathogenetic role of 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) gene polymorphisms in arterial hypertension]. (PMID: 18769825) Morales MA … Fardella CE (Revista medica de Chile 2008) 3 22 45 60
  4. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. (PMID: 17467270) Hennebert O … Morfin R (The Journal of steroid biochemistry and molecular biology 2007) 3 22 25 60
  5. Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. (PMID: 17062770) Smit P … Lamberts SW (The Journal of clinical endocrinology and metabolism 2007) 3 22 45 60

Products for HSD11B1 Gene

Sources for HSD11B1 Gene

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