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Aliases for HSCB Gene

Aliases for HSCB Gene

  • HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone 2 3 5
  • DNAJC20 3 4
  • HSC20 3 4
  • HscB Iron-Sulfur Cluster Co-Chaperone Homolog (E. Coli) 2
  • HscB Iron-Sulfur Cluster Co-Chaperone Homolog 3
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 20 3
  • DnaJ Homolog Subfamily C Member 20 4
  • J-Type Co-Chaperone HSC20 3
  • DnaJ (Hsp40) Homolog 2
  • Subfamily C 2
  • Member 20 2
  • JAC1 3

External Ids for HSCB Gene

Previous GeneCards Identifiers for HSCB Gene

  • GC22P027468
  • GC22P029138
  • GC22P012103

Summaries for HSCB Gene

Entrez Gene Summary for HSCB Gene

  • This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for HSCB Gene

HSCB (HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Transport to the Golgi and subsequent modification. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for HSCB Gene

  • Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSCB Gene

Genomics for HSCB Gene

Regulatory Elements for HSCB Gene

Enhancers for HSCB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HSCB on UCSC Golden Path with GeneCards custom track

Promoters for HSCB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HSCB on UCSC Golden Path with GeneCards custom track

Genomic Location for HSCB Gene

28,742,001 bp from pter
28,757,518 bp from pter
15,518 bases
Plus strand

Genomic View for HSCB Gene

Genes around HSCB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HSCB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HSCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSCB Gene

Proteins for HSCB Gene

  • Protein details for HSCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BWS7

    Protein attributes for HSCB Gene

    235 amino acids
    Molecular mass:
    27422 Da
    Quaternary structure:
    • Interacts with ISCU and HSPA9.

    Three dimensional structures from OCA and Proteopedia for HSCB Gene

neXtProt entry for HSCB Gene

Proteomics data for HSCB Gene at MOPED

Post-translational modifications for HSCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSCB Gene

No data available for DME Specific Peptides for HSCB Gene

Domains & Families for HSCB Gene

Gene Families for HSCB Gene

Protein Domains for HSCB Gene

Suggested Antigen Peptide Sequences for HSCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Belongs to the HscB family.
  • Contains 1 J domain.
  • Belongs to the HscB family.
genes like me logo Genes that share domains with HSCB: view

Function for HSCB Gene

Molecular function for HSCB Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.

Gene Ontology (GO) - Molecular Function for HSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HSCB: view
genes like me logo Genes that share phenotypes with HSCB: view

Animal Model Products

miRNA for HSCB Gene

miRTarBase miRNAs that target HSCB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HSCB Gene

Localization for HSCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSCB Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for HSCB Gene COMPARTMENTS Subcellular localization image for HSCB gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 3
cytoskeleton 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for HSCB Gene

Pathways & Interactions for HSCB Gene

genes like me logo Genes that share pathways with HSCB: view

Pathways by source for HSCB Gene

2 Reactome pathways for HSCB Gene

UniProtKB/Swiss-Prot Q8IWL3-HSC20_HUMAN

  • Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis.

Gene Ontology (GO) - Biological Process for HSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IMP 20668094
GO:0051259 protein oligomerization IEA --
genes like me logo Genes that share ontologies with HSCB: view

No data available for SIGNOR curated interactions for HSCB Gene

Drugs & Compounds for HSCB Gene

(1) Additional Compounds for HSCB Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
genes like me logo Genes that share compounds with HSCB: view

Transcripts for HSCB Gene

Unigene Clusters for HSCB Gene

HscB iron-sulfur cluster co-chaperone homolog (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HSCB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -

Relevant External Links for HSCB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSCB Gene

mRNA expression in normal human tissues for HSCB Gene

Protein differential expression in normal tissues from HIPED for HSCB Gene

This gene is overexpressed in Heart (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSCB Gene

SOURCE GeneReport for Unigene cluster for HSCB Gene Hs.632780

mRNA Expression by UniProt/SwissProt for HSCB Gene

Tissue specificity: Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
genes like me logo Genes that share expression patterns with HSCB: view

Protein tissue co-expression partners for HSCB Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSCB Gene

Orthologs for HSCB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSCB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSCB 35
  • 87.52 (n)
  • 85.11 (a)
  • 85 (a)
(Canis familiaris)
Mammalia HSCB 35
  • 88.79 (n)
  • 85.53 (a)
  • 86 (a)
(Mus musculus)
Mammalia Hscb 35
  • 80.48 (n)
  • 73.5 (a)
Hscb 16
Hscb 36
  • 74 (a)
(Pan troglodytes)
Mammalia HSCB 35
  • 99.43 (n)
  • 98.3 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Hscb 35
  • 79.91 (n)
  • 73.5 (a)
(Monodelphis domestica)
Mammalia HSCB 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia HSCB 36
  • 71 (a)
(Gallus gallus)
Aves HSCB 35
  • 60.21 (n)
  • 54.05 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hscb 35
  • 56.87 (n)
  • 46.93 (a)
(Danio rerio)
Actinopterygii si:ch211-207k7.4 35
  • 54.53 (n)
  • 46.74 (a)
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004722 35
  • 50.41 (n)
  • 36.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)72Do 35
  • 44.17 (n)
  • 32.04 (a)
l(3)72Do 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea dnj-15 35
  • 46.35 (n)
  • 32.62 (a)
dnj-15 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JAC1 36
  • 24 (a)
JAC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06410 35
  • 49.46 (n)
  • 34.41 (a)
(Oryza sativa)
Liliopsida Os12g0456200 35
  • 46.81 (n)
  • 37.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1107 36
  • 29 (a)
Species with no ortholog for HSCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSCB Gene

Gene Tree for HSCB (if available)
Gene Tree for HSCB (if available)

Paralogs for HSCB Gene

No data available for Paralogs for HSCB Gene

Variants for HSCB Gene

Sequence variations from dbSNP and Humsavar for HSCB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_048916 -
rs17884212 - 28,745,929(-) ATTTC(C/T)ATGAG intron-variant, nc-transcript-variant, reference, missense
rs2347446 -- 28,748,905(+) gaggc(C/T)gaagt intron-variant
rs7511528 -- 28,744,318(+) aggcc(C/G)aggca intron-variant
rs34248463 -- 28,751,584(+) CTACT(-/A)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSCB Gene

Variant ID Type Subtype PubMed ID
nsv9895 CNV Gain+Loss 18304495
nsv834169 CNV Loss 17160897

Variation tolerance for HSCB Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HSCB Gene

Disorders for HSCB Gene

Relevant External Links for HSCB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HSCB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HSCB Gene

Publications for HSCB Gene

  1. Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J- type co-chaperone. (PMID: 12938016) Sun G. … Vickery L.E. (J. Hum. Genet. 2003) 2 3 4 23 67
  2. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. (PMID: 16952052) Qiu X.B. … Wang L. (Cell. Mol. Life Sci. 2006) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. The presence of multiple cellular defects associated with a novel G50E iron-sulfur cluster scaffold protein (ISCU) mutation leads to development of mitochondrial myopathy. (PMID: 24573684) Saha P.P. … D'Silva P. (J. Biol. Chem. 2014) 3
  5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3

Products for HSCB Gene

Sources for HSCB Gene