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HSCB Gene

protein-coding   GIFtS: 58
GCID: GC22P029138

HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone

(Previous name: HscB iron-sulfur cluster co-chaperone homolog (E. coli))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone1 2     Subfamily C1
HSC202 3 5     dJ366L4.22
DnaJ Homolog Subfamily C Member 202 3     DnaJ (Hsp40) Homolog, Subfamily C, Member 202
DNAJC202 3     HscB Iron-Sulfur Cluster Co-Chaperone Homolog2
JAC12 5     Iron-Sulfur Cluster Co-Chaperone Protein HscB, Mitochondrial2
DnaJ (Hsp40) Homolog1     J-Type Co-Chaperone HSC202
HscB Iron-Sulfur Cluster Co-Chaperone Homolog (E. Coli)1     Hsc203
Member 201     

External Ids:    HGNC: 289131   Entrez Gene: 1502742   Ensembl: ENSG000001002097   OMIM: 6081425   UniProtKB: Q8IWL33   
ORGUL members:         

Export aliases for HSCB gene to outside databases

Previous GC identifers: GC22P027468 GC22P012103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HSCB Gene:
HSCB (HscB mitochondrial iron-sulfur cluster co-chaperone) is a protein-coding gene. Diseases associated with HSCB include x-linked sideroblastic anemia with ataxia, and x-linked sideroblastic anemia. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3
Function: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HSCB gene promoter:
         SREBP-1a   p300   IRF-7A   STAT3   CUTL1   Pax-4a   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HSCB promoter sequence
   Search Chromatin IP Primers for HSCB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HSCB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

HSCB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HSCB gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P029138:  view genomic region     (about GC identifiers)

Start:
29,138,019 bp from pter      End:
29,153,503 bp from pter
Size:
15,485 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3 (See protein sequence)
Recommended Name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial precursor  
Size: 235 amino acids; 27422 Da
Subunit: Interacts with ISCU and HSPA9
1 PDB 3D structure from and Proteopedia for HSCB:
3BVO (3D)    
Secondary accessions: Q9BWS7

Explore the universe of human proteins at neXtProt for HSCB: NX_Q8IWL3

Explore proteomics data for HSCB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HSCB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_741999.3  
    ENSEMBL proteins: 
     ENSP00000216027   ENSP00000406284   ENSP00000381914   ENSP00000416679  
    Reactome Protein details: Q8IWL3

    HSCB Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for HSCB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DNAJ: Heat shock proteins / DNAJ (HSP40)

    3 InterPro protein domains:
     IPR009073 HscB_oligo_C
     IPR001623 DnaJ_domain
     IPR004640 HscB

    Graphical View of Domain Structure for InterPro Entry Q8IWL3

    ProtoNet protein and cluster: Q8IWL3

    1 Blocks protein domain: IPB012895 HSCB oligomerisation

    UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3
    Similarity: Belongs to the HscB family
    Similarity: Contains 1 J domain


    HSCB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HSC20_HUMAN, Q8IWL3
    Function: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
    GO:0051087chaperone binding IEA--
         
    HSCB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HSCB:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HSCB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HSCB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HSCB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HSCB

    miRNA
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    miRTarBase miRNAs that target HSCB:
    hsa-mir-1303 (MIRT035893)

    Block miRNA regulation of human, mouse, rat HSCB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSCB
    SwitchGear 3'UTR luciferase reporter plasmidHSCB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HSCB

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HSC20_HUMAN, Q8IWL3: Cytoplasm. Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    cytoskeleton1
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS12938016
    GO:0005813centrosome IDA--
    GO:0005886plasma membrane IDA--

    HSCB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HSCB About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HSCB
        Mitochondrial protein import


    UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3
    Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis


    HSCB for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HSCB
    Interactions:

        Search GeneGlobe Interaction Network for HSCB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HSCB (Q8IWL33 ENSP000002160274) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BBS2Q9BXC93, ENSP000002451574I2D: score=1 STRING: ENSP00000245157
    BBS4Q96RK43, ENSP000002680574I2D: score=1 STRING: ENSP00000268057
    BBS1Q8NFJ93I2D: score=1 
    ISCUENSP000003106234STRING: ENSP00000310623
    SOD1ENSP000002701424STRING: ENSP00000270142
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding IEA--
    GO:0016226iron-sulfur cluster assembly IMP--
    GO:0051259protein oligomerization IEA--

    HSCB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HSCB (HSC20)

    1 HMDB Compound for HSCB    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HSCB gene: 
    NM_172002.3  

    Unigene Cluster for HSCB:

    HscB iron-sulfur cluster co-chaperone homolog (E. coli)
    Hs.632780  [show with all ESTs]
    Unigene Representative Sequence: BF686324
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216027(uc003aea.3) ENST00000450178 ENST00000398941 ENST00000420442
    ENST00000485599 ENST00000483861 ENST00000495977
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HSCB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HSCB
    SwitchGear 3'UTR luciferase reporter plasmidHSCB 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: HSCB (NM_172002)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HSCB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HSCB
      QuantiTect SYBR Green Assays in human, mouse, rat HSCB
      QuantiFast Probe-based Assays in human, mouse, rat HSCB

    Additional mRNA sequence: 

    AY191719.1 BC065569.1 CR456462.1 

    6 DOTS entries:

    DT.100881586  DT.92419123  DT.106300  DT.100881578  DT.120637807  DT.40302327 

    Selected AceView cDNA sequences (see all 54):

    AI203804 NM_172002 BC000004 CR456462 BM811398 BQ642442 BI518530 CB046828 
    AA804625 AI141716 AI796137 AI739537 BC065569 BU195420 BU069809 AI826906 
    BQ054405 BQ430738 BE782421 BE327697 AY191719 AI091767 BM852301 BE615999 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HSCB    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:        -                                       
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for HSCB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HSCB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCGCGTG
    HSCB Expression
    About this image

    HSCB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HSCB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632780

    UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3
    Tissue specificity: Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HSCB gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hscb1 , 5 HscB iron-sulfur cluster co-chaperone homolog (E. coli)1, 5 80.48(n)1
    73.5(a)1
      5 (53.72 cM)5
    1009001  NM_153571.21  NP_705799.21 
     1108290705 
    chicken
    (Gallus gallus)
    Aves HSCB1 HscB iron-sulfur cluster co-chaperone homolog (E. coli) 60.21(n)
    54.05(a)
      768938  XM_003642207.2  XP_003642255.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia AW633901.12   -- 68.72(n)    AW633901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-207k7.41 si:ch211-207k7.4 54.53(n)
    46.74(a)
      100150029  NM_001128398.1  NP_001121870.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)72Do1 lethal (3) 72Do 44.17(n)
    32.04(a)
      5740624  NM_001104146.3  NP_001097616.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnj-151 dnj-15 46.35(n)
    32.62(a)
      187149  NM_068105.2  NP_500506.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes JAC1(YGL018C)4 Specialized J-protein that functions with Hsp70 in more   --   7(459664-459110) 852866  NP_011497.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G064101 AT5G06410 49.46(n)
    34.41(a)
      830529  NM_120724.2  NP_196259.2 
    rice
    (Oryza sativa)
    Liliopsida Os12g04562001 Os12g0456200 46.81(n)
    37.16(a)
      4352172  NM_001073261.1  NP_001066729.1 


    ENSEMBL Gene Tree for HSCB (if available)
    TreeFam Gene Tree for HSCB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HSCB (see all 358)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008123341,2
    C--29139875(+) CAACCA/GTTCCT 2 H R mis10--------
    rs2013982091,2
    C--29139876(+) AACCGT/CTCCTT 2 /R syn11Minor allele frequency- C:0.00EU 1323
    rs1875134001,2
    C--29139897(+) ACAGCA/GAAGCT 2 A syn10--------
    rs2008840851,2
    --29139978(+) TATTGA/GCCAAC 1 -- int10--------
    rs1504607941,2
    --29140231(+) GCCTGC/TCCATT 1 -- int10--------
    rs178851091,2
    C,F--29140282(-) GATTAC/TAGGCG 1 -- int11Minor allele frequency- T:0.01NS 168
    rs1495900801,2
    --29140403(+) AGTGCA/CGTGAC 1 -- int10--------
    rs768330051,2
    C,F--29140421(+) TGTAGT/GCCCAG 1 -- int12Minor allele frequency- G:0.10WA 120
    rs178827001,2
    C,F--29140494(-) GGCGCG/AAACTC 1 -- int12Minor allele frequency- A:0.02NS WA 292
    rs96255511,2
    C,F,H--29140529(+) TCAACG/ATCAAA 1 -- int18Minor allele frequency- A:0.06NS EA NA 836

    HapMap Linkage Disequilibrium report for HSCB (29138019 - 29153503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HSCB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834169CNV Loss17160897
    nsv9895CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HSCB
    DNA2.0 Custom Variant and Variant Library Synthesis for HSCB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608142    OMIM disorders: --

    12 diseases for HSCB:    
    About MalaCards
    x-linked sideroblastic anemia with ataxia    x-linked sideroblastic anemia    sideroblastic anemia    friedreich ataxia
    esophageal squamous cell carcinoma    bardet-biedl syndrome    ataxia    gastric adenocarcinoma
    esophagitis    squamous cell carcinoma    malaria    adenocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for HSCB:
    X-linked sideroblastic anemia with ataxia     Friedreich ataxia

    HSCB for disorders           About GeneDecksing

    Genetic Association Database (GAD): HSCB
    Human Genome Epidemiology (HuGE) Navigator: HSCB (1 document)

    Export disorders for HSCB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HSCB gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with HSCB)
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    1. Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J- type co-chaperone. (PubMed id 12938016)1, 2, 3, 9 Sun G.... Vickery L.E. (J. Hum. Genet. 2003)
    2. Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. (PubMed id 20668094)1, 2 Uhrigshardt H.... Rouault T.A. (Hum. Mol. Genet. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. (PubMed id 18713742)1, 2 Bitto E.... Phillips G.N. Jr. (J. Biol. Chem. 2008)
    5. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. (PubMed id 16952052)1, 3 Qiu X.B....Wang L. (Cell. Mol. Life Sci. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    9. Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU). (PubMed id 23940031)1 Cai K....Markley J.L. (J. Biol. Chem. 2013)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 150274 HGNC: 28913 AceView: HSC20 Ensembl:ENSG00000100209 euGenes: HUgn150274
    ECgene: HSCB H-InvDB: HSCB

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HSCB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HSCB gene:
    Search GeneIP for patents involving HSCB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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