HSCB Gene
protein-coding GIFtS: 54
GCID: GC22P029138
|
|
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
| |
Aliases for HSCB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| HscB Iron-Sulfur Cluster Co-Chaperone Homolog (E. Coli)1 2 | | DJ366L4.21 | | HSC201 2 3 5 | | DnaJ (Hsp40) Homolog, Subfamily C, Member 202 | | DNAJC201 2 3 | | Iron-Sulfur Cluster Co-Chaperone Protein HscB, Mitochondrial2 | | DnaJ Homolog Subfamily C Member 202 3 | | J-Type Co-Chaperone HSC202 | | JAC12 5 | | Hsc203 | | Jac11 | | |
Export aliases for HSCB gene to outside databasesPrevious GC identifers: GC22P027468 GC22P012103 |
Summaries for HSCB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3Function: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria
|
Genomic Views for HSCB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HSCB gene promoter: SREBP-1a p300 IRF-7A STAT3 CUTL1 Pax-4a SREBP-1b Other transcription factors
Search SABiosciences Chromatin IP Primers for HSCB
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSCB |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.1 Ensembl cytogenetic band: 22q12.1 HGNC cytogenetic band: 22q12.1HSCB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P029138: view genomic region
(about GC identifiers)
Start:
|
29,138,019 bp from pter |
End:
|
29,153,503 bp from pter |
Size:
|
15,485 bases |
Orientation:
|
plus strand |
|
Proteins for HSCB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3 (See
protein sequence)Recommended Name: Iron-sulfur cluster co-chaperone protein HscB, mitochondrial precursor Size: 235 amino acids; 27422 Da
Subunit: Interacts with ISCU and HSPA9
Subcellular location: Cytoplasm. Mitochondrion
1 PDB 3D structure from and Proteopedia for HSCB:3BVO (3D)
 
Secondary accessions: Q9BWS7Explore the universe of human proteins at neXtProt for HSCB: NX_Q8IWL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWL3 HSCB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_741999.3 ENSEMBL proteins: ENSP00000216027 ENSP00000406284 ENSP00000381914 ENSP00000416679 Reactome Protein details: Q8IWL3 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HSCB for ontologies About GeneDecksing
HSCB Antibody Products: Assay Products for HSCB: |
Protein
Domains / Families for HSCB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HSCB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWL3ProtoNet protein and cluster: Q8IWL3 1 Blocks protein family: IPB012895 HSCB oligomerisation
UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3Similarity: Belongs to the HscB familySimilarity: Contains 1 J domain |
Function for HSCB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3Function: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSCB (NM_172002) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSCB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSCB  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSCB |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
HSCB for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HSCB:
|
Pathways & Interactions for HSCB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mitochondrial Protein Import | | | 2 | Asparagine N-linked glycosylation | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Reactome Pathways for HSCB
UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis
HSCB for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HSCB
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
 5/11 Interacting proteins for HSCB (Q8IWL33 ENSP000002160274) via UniProtKB, MINT, STRING, and/or I2D (see all 11) About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006457 | protein folding |
IEA | -- | | GO:0016226 | iron-sulfur cluster assembly |
IMP | -- |
HSCB for ontologies About GeneDecksing
|
Drugs & Compounds for HSCB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for HSCB
1 HMDB Compound for HSCB About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Iron | Armco iron (see all 19) | 7439-89-6 | -- | Search CenterWatch for drugs/clinical trials and news about HSCB / HSC20 
|
Transcripts for HSCB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for HSCB gene: NM_172002.3 Unigene Cluster for HSCB: HscB iron-sulfur cluster co-chaperone homolog (E. coli) Hs.632780 [show with all ESTs]Unigene Representative Sequence: BF6863247 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216027(uc003aea.3) ENST00000450178 ENST00000398941 ENST00000420442 ENST00000485599 ENST00000483861 ENST00000495977
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HSCB (NM_172002) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HSCB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSCB  |
Additional cDNA sequence: AY191719.1 BC065569.1 CR456462.1 6 DOTS entries: DT.100881586 DT.92419123 DT.106300 DT.120637807 DT.100881578 DT.40302327 24/54 AceView cDNA sequences (see all 54): CB046828 AI739537 AI203804 NM_172002 BI518530 CR456462 BM811398 BC065569 BC000004 BQ642442 AI141716 BQ054405 BU195420 AA804625 BU069809 AI796137 AI826906 BE856024 BU858060 AY191719 BG696148 BE327697 BM852301 AW250733 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for HSCB About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | |
| SP1: | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for HSCB
|
Expression for HSCB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HSCB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GTGGCGCGTG
About this image See HSCB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HSCB
SOURCE GeneReport for Unigene cluster: Hs.632780 UniProtKB/Swiss-Prot: HSC20_HUMAN, Q8IWL3Tissue specificity: Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart SABiosciences Custom PCR Arrays for HSCB
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSCB Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HSCB | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSCB | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSCB | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSCB |
Orthologs for HSCB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for HSCB gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for HSCB (if available) TreeFam Gene Tree for HSCB (if available)  |
Paralogs for HSCB gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for HSCB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 22 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for HSCB (29138019 - 29153503 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HSCB: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSCB |
|
Disorders
/ Diseases for HSCB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HSCB for disorders About GeneDecksing
OMIM gene information: 608142
OMIM disorders: --
12 diseases for HSCB: About MalaCardsx-linked sideroblastic anemia x-linked sideroblastic anemia with ataxia sideroblastic anemia friedreich ataxia esophageal squamous cell carcinoma squamous cell carcinoma ataxia esophagitis anemia carcinoma adenocarcinoma malaria 2 diseases from the University of Copenhagen DISEASES database for HSCB:X-linked sideroblastic anemia with ataxia Friedreich ataxia Human Genome Epidemiology (HuGE) Navigator: HSCB (1 document) Export disorders for HSCB gene to outside databases
|
Publications for HSCB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HSCB gene, integrated from 9 sources (see all 11): (articles sorted by number of sources associating them with HSCB) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J- type co-chaperone. (PubMed id 12938016)1, 2, 3, 9 Sun G.... Vickery L.E. (2003)
- Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. (PubMed id 20668094)1, 2 Uhrigshardt H....Rouault T.A. (2010)
- Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. (PubMed id 18713742)1, 2 Bitto E.... Phillips G.N. Jr. (2008)
- The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. (PubMed id 16952052)1, 3 Qiu X.B....Wang L. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A shared susceptibility locus in PLCE1 at 10q23 for g astric adenocarcinoma and esophageal squamous cell carcinoma. (PubMed id 20729852)1 Abnet C.C....Taylor P.R. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for HSCB gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HSCB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HSCB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HSCB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for HSCB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HSCB gene: Search GeneIP for patents involving HSCB
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for HSCB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for HSCB | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HSCB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HSCB | | OriGene Protein Over-expression Lysate for HSCB | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for HSCB | | OriGene 3'-UTR Clone for HSCB | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HSCB | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | OriGene Purified Protein for HSCB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for HSCB | | OriGene Custom Protein Services for HSCB | | OriGene Custom Immunoassay Development | | |
| |  |
 |
| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HSCB | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HSCB | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HSCB | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HSCB | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HSCB | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HSCB |
| |
 |  |  |  | |
| | | Search Tocris compounds for HSCB |
| |  |  |  |  | | | | | Recombinant Protein for HSCB |
|
 |
 |
 |
 | | HSCB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HSCB |
|  |  |  | | | Search ThermoFisher Antibodies for HSCB |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HSCB |
|
|
|
|