Aliases for HSCB Gene
External Ids for HSCB Gene
Previous GeneCards Identifiers for HSCB Gene
This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for HSCB Gene
HSCB (HscB Mitochondrial Iron-Sulfur Cluster Cochaperone) is a Protein Coding gene. Among its related pathways are Mitochondrial protein import and Metabolism of proteins. GO annotations related to this gene include chaperone binding.
UniProtKB/Swiss-Prot for HSCB Gene
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.