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Aliases for HSCB Gene

Aliases for HSCB Gene

  • HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone 2 3
  • HSC20 3 4 6
  • DnaJ Homolog Subfamily C Member 20 3 4
  • DNAJC20 3 4
  • JAC1 3 6
  • Iron-Sulfur Cluster Co-Chaperone Protein HscB, Mitochondrial 3
  • HscB Iron-Sulfur Cluster Co-Chaperone Homolog (E. Coli) 2
  • HscB Iron-Sulfur Cluster Co-Chaperone Homolog 3
  • DnaJ (Hsp40) Homolog, Subfamily C, Member 20 3
  • J-Type Co-Chaperone HSC20 3
  • DnaJ (Hsp40) Homolog 2
  • Subfamily C 2
  • Member 20 2
  • DJ366L4.2 3

External Ids for HSCB Gene

Previous GeneCards Identifiers for HSCB Gene

  • GC22P027468
  • GC22P029138
  • GC22P012103

Summaries for HSCB Gene

GeneCards Summary for HSCB Gene

HSCB (HscB Mitochondrial Iron-Sulfur Cluster Co-Chaperone) is a Protein Coding gene. Diseases associated with HSCB include x-linked sideroblastic anemia with ataxia and bardet-biedl syndrome. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Mitochondrial Protein Import. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for HSCB Gene

  • Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HSCB Gene

Genomics for HSCB Gene

Regulatory Elements for HSCB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HSCB Gene

28,742,023 bp from pter
28,757,518 bp from pter
15,496 bases
Plus strand

Genomic View for HSCB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HSCB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HSCB Gene

Proteins for HSCB Gene

  • Protein details for HSCB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iron-sulfur cluster co-chaperone protein HscB, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BWS7

    Protein attributes for HSCB Gene

    235 amino acids
    Molecular mass:
    27422 Da
    Quaternary structure:
    • Interacts with ISCU and HSPA9.

    Three dimensional structures from OCA and Proteopedia for HSCB Gene

neXtProt entry for HSCB Gene

Proteomics data for HSCB Gene at MOPED

Post-translational modifications for HSCB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HSCB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HSCB Gene

Domains for HSCB Gene

Gene Families for HSCB Gene

Protein Domains for HSCB Gene

Suggested Antigen Peptide Sequences for HSCB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 J domain.
  • Belongs to the HscB family.
  • Contains 1 J domain.
  • Belongs to the HscB family.
genes like me logo Genes that share domains with HSCB: view

Function for HSCB Gene

Molecular function for HSCB Gene

UniProtKB/Swiss-Prot Function:
Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria.

Gene Ontology (GO) - Molecular Function for HSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 20668094
GO:0046872 metal ion binding IEA --
GO:0051087 chaperone binding IEA --
genes like me logo Genes that share ontologies with HSCB: view

Phenotypes for HSCB Gene

GenomeRNAi human phenotypes for HSCB:
genes like me logo Genes that share phenotypes with HSCB: view

Animal Model Products

miRNA for HSCB Gene

miRTarBase miRNAs that target HSCB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSCB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HSCB Gene

Localization for HSCB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HSCB Gene

Cytoplasm. Mitochondrion.

Subcellular locations from

Jensen Localization Image for HSCB Gene COMPARTMENTS Subcellular localization image for HSCB gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytoskeleton 1
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion TAS 12938016
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HSCB: view

Pathways for HSCB Gene

genes like me logo Genes that share pathways with HSCB: view

Pathways by source for HSCB Gene

2 Reactome pathways for HSCB Gene

UniProtKB/Swiss-Prot Q8IWL3-HSC20_HUMAN

  • Pathway: Cofactor biosynthesis; iron-sulfur cluster biosynthesis

Gene Ontology (GO) - Biological Process for HSCB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding IEA --
GO:0016226 iron-sulfur cluster assembly IMP 20668094
GO:0051259 protein oligomerization IEA --
genes like me logo Genes that share ontologies with HSCB: view

Compounds for HSCB Gene

(1) HMDB Compounds for HSCB Gene

Compound Synonyms Cas Number PubMed IDs
  • Armco iron
genes like me logo Genes that share compounds with HSCB: view

Transcripts for HSCB Gene

Unigene Clusters for HSCB Gene

HscB iron-sulfur cluster co-chaperone homolog (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HSCB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HSCB Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -

Relevant External Links for HSCB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HSCB Gene

mRNA expression in normal human tissues for HSCB Gene

Protein differential expression in normal tissues for HSCB Gene

This gene is overexpressed in Heart (27.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HSCB Gene

SOURCE GeneReport for Unigene cluster for HSCB Gene Hs.632780

mRNA Expression by UniProt/SwissProt for HSCB Gene

Tissue specificity: Expressed in lung, brain, stomach, spleen, ovary, testis, liver, muscle and heart.
genes like me logo Genes that share expressions with HSCB: view

Expression partners for HSCB Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HSCB Gene

Orthologs for HSCB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HSCB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HSCB 35
  • 87.52 (n)
  • 85.11 (a)
  • 85 (a)
(Canis familiaris)
Mammalia HSCB 35
  • 88.79 (n)
  • 85.53 (a)
  • 86 (a)
(Mus musculus)
Mammalia Hscb 35
  • 80.48 (n)
  • 73.5 (a)
Hscb 16
Hscb 36
  • 74 (a)
(Pan troglodytes)
Mammalia HSCB 35
  • 99.43 (n)
  • 98.3 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Hscb 35
  • 79.91 (n)
  • 73.5 (a)
(Monodelphis domestica)
Mammalia HSCB 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia HSCB 36
  • 71 (a)
(Gallus gallus)
Aves HSCB 35
  • 60.21 (n)
  • 54.05 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hscb 35
  • 56.87 (n)
  • 46.93 (a)
(Danio rerio)
Actinopterygii si:ch211-207k7.4 35
  • 54.53 (n)
  • 46.74 (a)
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004722 35
  • 50.41 (n)
  • 36.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)72Do 35
  • 44.17 (n)
  • 32.04 (a)
l(3)72Do 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea dnj-15 35
  • 46.35 (n)
  • 32.62 (a)
dnj-15 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes JAC1 36
  • 24 (a)
JAC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G06410 35
  • 49.46 (n)
  • 34.41 (a)
(Oryza sativa)
Liliopsida Os12g0456200 35
  • 46.81 (n)
  • 37.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1107 36
  • 29 (a)
Species with no ortholog for HSCB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HSCB Gene

Gene Tree for HSCB (if available)
Gene Tree for HSCB (if available)

Paralogs for HSCB Gene

No data available for Paralogs for HSCB Gene

Variants for HSCB Gene

Sequence variations from dbSNP and Humsavar for HSCB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs714191 -- 28,749,423(+) taagc(C/T)atcta intron-variant
rs717869 -- 28,749,689(+) GGGAC(C/T)GTCAG intron-variant
rs1141915 -- 28,751,522(-) gatcc(G/T)cccgc intron-variant
rs2347446 -- 28,748,905(+) gaggc(C/T)gaagt intron-variant
rs4822987 -- 28,748,512(+) TTTTT(G/T)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HSCB Gene

Variant ID Type Subtype PubMed ID
nsv9895 CNV Gain+Loss 18304495
nsv834169 CNV Loss 17160897

Relevant External Links for HSCB Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HSCB Gene

Disorders for HSCB Gene

(2) University of Copenhagen DISEASES for HSCB Gene

Relevant External Links for HSCB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HSCB: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for HSCB Gene

Publications for HSCB Gene

  1. Identification of a novel candidate gene in the iron-sulfur pathway implicated in ataxia-susceptibility: human gene encoding HscB, a J- type co-chaperone. (PMID: 12938016) Sun G. … Vickery L.E. (J. Hum. Genet. 2003) 2 3 4 23
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  3. Structure of human J-type co-chaperone HscB reveals a tetracysteine metal-binding domain. (PMID: 18713742) Bitto E. … Phillips G.N. Jr. (J. Biol. Chem. 2008) 3 4
  4. Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. (PMID: 20668094) Uhrigshardt H. … Rouault T.A. (Hum. Mol. Genet. 2010) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for HSCB Gene

  • Addgene plasmids for HSCB

Sources for HSCB Gene

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